JP3391796B2 - 新規化合物、その製法および抗腫瘍剤 - Google Patents
新規化合物、その製法および抗腫瘍剤Info
- Publication number
- JP3391796B2 JP3391796B2 JP50192396A JP50192396A JP3391796B2 JP 3391796 B2 JP3391796 B2 JP 3391796B2 JP 50192396 A JP50192396 A JP 50192396A JP 50192396 A JP50192396 A JP 50192396A JP 3391796 B2 JP3391796 B2 JP 3391796B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- hydrogen atom
- halogen atom
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15657894 | 1994-06-14 | ||
| JP6-156578 | 1994-06-14 | ||
| JP6-197921 | 1994-07-28 | ||
| JP19792194 | 1994-07-28 | ||
| JP30691494 | 1994-11-15 | ||
| JP6-306914 | 1994-11-15 | ||
| JP33995694 | 1994-12-28 | ||
| JP6-339956 | 1994-12-28 | ||
| JP7-81705 | 1995-03-13 | ||
| JP8170595 | 1995-03-13 | ||
| PCT/JP1995/001110 WO1995034559A1 (fr) | 1994-06-14 | 1995-06-06 | Nouveau compose, son procede de production et agent antitumoral |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP3391796B2 true JP3391796B2 (ja) | 2003-03-31 |
Family
ID=27524935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50192396A Expired - Lifetime JP3391796B2 (ja) | 1994-06-14 | 1995-06-06 | 新規化合物、その製法および抗腫瘍剤 |
Country Status (26)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL369531A1 (en) * | 2001-09-26 | 2005-05-02 | Bayer Pharmaceuticals Corporation | 1,8-naphthyridine derivatives as antidiabetics |
| US6802423B2 (en) * | 2002-02-20 | 2004-10-12 | Trans Global Foods, Inc. | Disposable food delivery apparatus |
| EP1610795A4 (en) * | 2003-04-07 | 2007-10-24 | Cylene Pharmaceuticals Inc | SUBSTITUTED 1,4-DIHYDRO-4-OXO-1,8-NAPHTHPYRIDINE HETEROCYCLIC ANALOGUES |
| ES2424676T3 (es) * | 2003-09-10 | 2013-10-07 | Kyorin Pharmaceutical Co., Ltd. | Derivado de ácido 7-(3-ciclopropilaminometil-1-pirrolidinil 4-sustituido)quinoloncarboxílico |
| DE10352979A1 (de) * | 2003-11-13 | 2005-06-09 | Merck Patent Gmbh | Pyridopyrimidinone |
| CA2954578A1 (en) * | 2004-03-15 | 2005-09-29 | Sunesis Pharmaceuticals, Inc. | Methods of using sns-595 in treating cancer |
| AU2013201203C1 (en) * | 2004-03-15 | 2015-04-23 | Sumitomo Dainippon Pharma Co., Ltd. | Sns-595 and methods of using the same |
| RU2405781C2 (ru) * | 2004-10-14 | 2010-12-10 | Ф.Хоффманн-Ля Рош Аг | 1, 5-нафтиридиназолидиноны, обладающие cdk1 антипролиферативной активностью |
| CA2583311A1 (en) * | 2004-10-14 | 2006-04-20 | F. Hoffmann-La Roche Ag | Quinazolinylmethylenethiazolinones as cdk1 inhibitors |
| US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
| RU2420524C2 (ru) * | 2005-05-19 | 2011-06-10 | Дайити Санкио Компани, Лимитед | Производные три- или тетра-замещенного-3-аминопирролидина |
| JP2009504192A (ja) * | 2005-08-19 | 2009-02-05 | サイリーン ファーマシューティカルズ インコーポレーティッド | ヒトリボソームＤＮＡ（ｒＤＮＡ）およびリボソームＲＮＡ（ｒＲＮＡ）核酸ならびにそれらの使用 |
| CN104873502A (zh) * | 2005-09-02 | 2015-09-02 | 逊尼希思制药公司 | 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法 |
| AU2006287149B2 (en) * | 2005-09-02 | 2013-05-23 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| RU2428983C2 (ru) * | 2005-09-02 | 2011-09-20 | Санесис Фармасьютикалз, Инк. | Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака |
| KR20170118936A (ko) * | 2005-09-02 | 2017-10-25 | 선에시스 파마슈티컬스 인코포레이티드 | 암 치료를 위한 (＋)-1,4-디히드로-7-［(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐］-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법 |
| US8580814B2 (en) * | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| AU2013219242C1 (en) * | 2005-09-02 | 2016-09-22 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
| BRPI0615838A2 (pt) * | 2005-09-14 | 2011-05-31 | Janssen Pharmaceutica Nv | 5-oxo-5,8-dihidro-pirido-pirimidinas como inibidores de ofc-fms cinase |
| US7642270B2 (en) | 2005-09-14 | 2010-01-05 | Janssen Pharmaceutica N.V. | 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase |
| TW200800983A (en) | 2005-09-14 | 2008-01-01 | Janssen Pharmaceutica Nv | 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase |
| BRPI0713637A2 (pt) * | 2006-06-12 | 2012-10-23 | Sunesis Pharmaceuticals Inc | composição, composto, e , método para o tratamento de cáncer |
| US20100048609A1 (en) * | 2006-08-01 | 2010-02-25 | Jacobs Jeffrey W | Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| MX344865B (es) * | 2006-08-02 | 2016-12-19 | Sunesis Pharmaceuticals Inc | Metodos para usar acido (+)-1,4-dihidro-7-[(3s,4s)-3-metoxi-4-(met ilamino)-1-pirrolidinil]-4-oxo-1(2-tiazolil)-1,8-naftiridina-3-ca rboxilico para el tratamiento de ciertos padecimientos hematologicos. |
| CA2703044C (en) * | 2007-10-22 | 2016-05-10 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
| AU2008335772B2 (en) * | 2007-12-10 | 2014-11-27 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3- methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1- (2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| BRPI0923780A2 (pt) * | 2008-12-31 | 2015-07-21 | Sunesis Pharmaceuticals Inc | Processo para preparar composto, processo para decomposição do composto, composto, composição, método para tratar câncer, e, pelo menos um quilograma de composto |
| SG173855A1 (en) | 2009-02-27 | 2011-09-29 | Sunesis Pharmaceuticals Inc | Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity |
| UA110465C2 (en) * | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| TW201120037A (en) * | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| EP2712358B1 (en) | 2011-05-13 | 2016-12-21 | Array Biopharma, Inc. | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors |
| CN103497186B (zh) * | 2013-09-24 | 2015-02-25 | 浙江司太立制药股份有限公司 | 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法 |
| WO2018174266A1 (ja) | 2017-03-24 | 2018-09-27 | 湧永製薬株式会社 | 新規ピリドンカルボン酸誘導体又はその塩 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3988463A (en) * | 1974-05-06 | 1976-10-26 | Merck & Co., Inc. | Method of preventing metastasis of H. Ep. No. 3 |
| US4384001A (en) * | 1978-12-21 | 1983-05-17 | Gosalvez Mario | Treatment of tumors with thiazolidine-4-carboxylic acid |
| US4730000A (en) * | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
| DE3577089D1 (de) * | 1984-01-26 | 1990-05-17 | Abbott Lab | Antibakterielle chinolinderivate. |
| NZ210847A (en) * | 1984-01-26 | 1988-02-29 | Abbott Lab | Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions |
| JPS61152682A (ja) * | 1984-12-27 | 1986-07-11 | Dainippon Pharmaceut Co Ltd | ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| JPS61251667A (ja) * | 1985-04-30 | 1986-11-08 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| GR861530B (en) * | 1985-06-13 | 1986-12-31 | Schering Corp | Preparation process for polycyclic quinoline of naphthyridine and pyrazinopyridine |
| EP0226624A1 (en) * | 1985-06-14 | 1987-07-01 | The Upjohn Company | Cyclopentapyrazole and tetrahydroindazole compounds |
| JPS6233176A (ja) * | 1985-08-05 | 1987-02-13 | Toyama Chem Co Ltd | １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩 |
| JP2704428B2 (ja) * | 1988-06-15 | 1998-01-26 | 富山化学工業株式会社 | キノロンカルボン酸誘導体またはその塩 |
| DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| JPH06233176A (ja) * | 1993-01-29 | 1994-08-19 | Sony Corp | ビデオカメラ |
-
1995
- 1995-06-06 MX MX9606331A patent/MX9606331A/es unknown
- 1995-06-06 JP JP50192396A patent/JP3391796B2/ja not_active Expired - Lifetime
- 1995-06-06 DE DE69524251T patent/DE69524251T2/de not_active Expired - Lifetime
- 1995-06-06 DK DK95920265T patent/DK0787726T3/da active
- 1995-06-06 KR KR1019960707029A patent/KR100350921B1/ko not_active Expired - Lifetime
- 1995-06-06 WO PCT/JP1995/001110 patent/WO1995034559A1/ja active IP Right Grant
- 1995-06-06 AT AT95920265T patent/ATE209645T1/de active
- 1995-06-06 CA CA002192824A patent/CA2192824C/en not_active Expired - Lifetime
- 1995-06-06 BR BR9508037A patent/BR9508037A/pt not_active IP Right Cessation
- 1995-06-06 US US08/765,232 patent/US5817669A/en not_active Expired - Lifetime
- 1995-06-06 RO RO96-02349A patent/RO117793B1/ro unknown
- 1995-06-06 ES ES95920265T patent/ES2163512T3/es not_active Expired - Lifetime
- 1995-06-06 AU AU25767/95A patent/AU679859B2/en not_active Expired
- 1995-06-06 SI SI9530567T patent/SI0787726T1/xx unknown
- 1995-06-06 HU HU9603455A patent/HU220072B/hu unknown
- 1995-06-06 CZ CZ19963643A patent/CZ292631B6/cs not_active IP Right Cessation
- 1995-06-06 NZ NZ287139A patent/NZ287139A/en not_active IP Right Cessation
- 1995-06-06 PT PT95920265T patent/PT787726E/pt unknown
- 1995-06-06 CN CN95194461A patent/CN1053668C/zh not_active Expired - Lifetime
- 1995-06-06 EP EP95920265A patent/EP0787726B1/en not_active Expired - Lifetime
- 1995-06-06 RU RU97100718/04A patent/RU2151770C1/ru active
- 1995-06-06 SK SK1574-96A patent/SK281341B6/sk not_active IP Right Cessation
- 1995-06-06 PL PL95317726A patent/PL181867B1/pl unknown
- 1995-06-13 TW TW084106000A patent/TW319769B/zh not_active IP Right Cessation
-
1996
- 1996-12-11 NO NO965305A patent/NO307255B1/no not_active IP Right Cessation
- 1996-12-13 FI FI965020A patent/FI112485B/fi not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Ｙｏｓｈｉｎｏｒｉ Ｙａｍａｓｈｉｔａ，ｅｔ ａｌ．，Ａｎｔｉｔｕｍｏｒ ｑｕｉｎｏｌｏｎｅｓ ｗｉｔｈ ｍａｍｍａｌｉａｎ ｔｏｐｏｉ ｓｏｍｅｒａｓｅ ▲ＩＩ▼ ｍｅｄｉａｔｅｄ ＤＮＡ ｃｌｅａｖａｇｅ ａｃｔｉｖｉｔｙ，Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ，Ｖｏｌ．５２，ｐ．２８１８−２８２２，１９９２ |
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