JP3210023B2 - ブロモ置換三環式化合物を調製する際に有用な中間体の合成 - Google Patents

ブロモ置換三環式化合物を調製する際に有用な中間体の合成

Info

Publication number
JP3210023B2
JP3210023B2 JP50447999A JP50447999A JP3210023B2 JP 3210023 B2 JP3210023 B2 JP 3210023B2 JP 50447999 A JP50447999 A JP 50447999A JP 50447999 A JP50447999 A JP 50447999A JP 3210023 B2 JP3210023 B2 JP 3210023B2
Authority
JP
Japan
Prior art keywords
formula
compound
hydrogen
alkyl
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50447999A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000513032A (ja
Inventor
キン チュン，
マーク ポイリアー，
イー−シン ウォン，
ガン−ゾン ウ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2000513032A publication Critical patent/JP2000513032A/ja
Application granted granted Critical
Publication of JP3210023B2 publication Critical patent/JP3210023B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP50447999A 1997-06-16 1998-06-15 ブロモ置換三環式化合物を調製する際に有用な中間体の合成 Expired - Fee Related JP3210023B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US882,753 1997-06-16
US08/882,753 1997-06-16
US08/882,753 US5760232A (en) 1997-06-16 1997-06-16 Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds
PCT/US1998/011403 WO1998057958A1 (en) 1997-06-16 1998-06-15 Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds

Publications (2)

Publication Number Publication Date
JP2000513032A JP2000513032A (ja) 2000-10-03
JP3210023B2 true JP3210023B2 (ja) 2001-09-17

Family

ID=25381267

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50447999A Expired - Fee Related JP3210023B2 (ja) 1997-06-16 1998-06-15 ブロモ置換三環式化合物を調製する際に有用な中間体の合成

Country Status (15)

Country Link
US (1) US5760232A (online.php)
EP (1) EP0991640B1 (online.php)
JP (1) JP3210023B2 (online.php)
AR (1) AR015886A1 (online.php)
AT (1) ATE214062T1 (online.php)
AU (1) AU8056898A (online.php)
CA (1) CA2293709C (online.php)
DE (1) DE69804100T2 (online.php)
DK (1) DK0991640T3 (online.php)
ES (1) ES2169917T3 (online.php)
IN (1) IN187755B (online.php)
MY (1) MY133531A (online.php)
PT (1) PT991640E (online.php)
WO (1) WO1998057958A1 (online.php)
ZA (1) ZA985207B (online.php)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
ATE533748T1 (de) * 2002-10-03 2011-12-15 Schering Corp Enantioselektive alkylierung von trizyklischen verbindungen
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
DK3738434T3 (da) 2011-12-28 2023-12-04 Global Blood Therapeutics Inc Mellemprodukter til opnåelse af substituerede benzaldehydforbindelser og fremgangsmåder til anvendelse deraf ved øgning af vævsoxygenering
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
AU2014237330A1 (en) 2013-03-15 2015-09-17 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
BR112015021982B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos e seus usos para a modulação de hemoglobina
KR102280614B1 (ko) 2013-03-15 2021-07-21 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
SI3102208T2 (sl) 2014-02-07 2024-10-30 Global Blood Therapeutics, Inc. Kristalinični polimorf proste baze 2-hidroksi-6-((2-(1-izopropil-1H-pirazol-5-IL)piridin-3-IL)metoksi)- benzaldehida
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
US11020382B2 (en) 2015-12-04 2021-06-01 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
WO2020163689A1 (en) 2019-02-08 2020-08-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 20-hete formation inhibitors
CN112341433A (zh) * 2020-11-16 2021-02-09 成都大学 一种氯雷他定的制备方法
WO2024251227A1 (zh) * 2023-06-08 2024-12-12 上海森辉医药有限公司 一种甲酰胺类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
SG48750A1 (en) * 1993-10-15 1998-05-18 Schering Corp Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CZ292791B6 (cs) * 1995-12-22 2003-12-17 Schering Corporation Tricyklické amidy, které se používají pro inhibici G-proteinové funkce a k léčení proliferativních onemocnění

Also Published As

Publication number Publication date
CA2293709C (en) 2004-02-10
WO1998057958A1 (en) 1998-12-23
CA2293709A1 (en) 1998-12-23
PT991640E (pt) 2002-07-31
DE69804100D1 (de) 2002-04-11
IN187755B (online.php) 2002-06-15
US5760232A (en) 1998-06-02
ATE214062T1 (de) 2002-03-15
JP2000513032A (ja) 2000-10-03
AR015886A1 (es) 2001-05-30
DE69804100T2 (de) 2002-10-31
EP0991640B1 (en) 2002-03-06
AU8056898A (en) 1999-01-04
DK0991640T3 (da) 2002-05-27
ES2169917T3 (es) 2002-07-16
EP0991640A1 (en) 2000-04-12
ZA985207B (en) 1999-04-07
MY133531A (en) 2007-11-30

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