JP3194020B2 - 腫瘍抗原特異的抗体、それを含む医薬組成物およびその抗体を産生する細胞系 - Google Patents
腫瘍抗原特異的抗体、それを含む医薬組成物およびその抗体を産生する細胞系Info
- Publication number
- JP3194020B2 JP3194020B2 JP17584892A JP17584892A JP3194020B2 JP 3194020 B2 JP3194020 B2 JP 3194020B2 JP 17584892 A JP17584892 A JP 17584892A JP 17584892 A JP17584892 A JP 17584892A JP 3194020 B2 JP3194020 B2 JP 3194020B2
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- antibody
- antibodies
- cells
- cell line
- antigen
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1057—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from liver or pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9102074A SE9102074D0 (sv) | 1991-07-03 | 1991-07-03 | Tomour antigen specific antibody |
| SE9102074-3 | 1991-07-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05276987A JPH05276987A (ja) | 1993-10-26 |
| JP3194020B2 true JP3194020B2 (ja) | 2001-07-30 |
Family
ID=20383243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17584892A Expired - Lifetime JP3194020B2 (ja) | 1991-07-03 | 1992-07-03 | 腫瘍抗原特異的抗体、それを含む医薬組成物およびその抗体を産生する細胞系 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5552293A (enExample) |
| EP (1) | EP0521842B1 (enExample) |
| JP (1) | JP3194020B2 (enExample) |
| KR (1) | KR100246681B1 (enExample) |
| AT (1) | ATE171193T1 (enExample) |
| AU (2) | AU658198B2 (enExample) |
| CA (1) | CA2073124C (enExample) |
| DE (1) | DE69226990T2 (enExample) |
| DK (1) | DK0521842T3 (enExample) |
| EE (1) | EE03031B1 (enExample) |
| ES (1) | ES2124250T3 (enExample) |
| FI (1) | FI109207B (enExample) |
| HU (2) | HU218084B (enExample) |
| IE (1) | IE80841B1 (enExample) |
| IL (1) | IL102390A (enExample) |
| NO (1) | NO315472B1 (enExample) |
| NZ (1) | NZ243435A (enExample) |
| SE (1) | SE9102074D0 (enExample) |
| WO (2) | WO1993001302A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9402430L (sv) | 1994-07-11 | 1996-01-12 | Pharmacia Ab | Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten |
| SE9601245D0 (sv) | 1996-03-29 | 1996-03-29 | Pharmacia Ab | Chimeric superantigens and their use |
| TW517061B (en) | 1996-03-29 | 2003-01-11 | Pharmacia & Amp Upjohn Ab | Modified/chimeric superantigens and their use |
| ATE200679T1 (de) * | 1997-04-14 | 2001-05-15 | Micromet Ag | Neues verfahren zur herstellung von anti-humanen antigenrezeptoren und deren verwendungen |
| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
| ES2619313T3 (es) * | 2001-03-15 | 2017-06-26 | Precision Biologics, Inc. | Terapia de anticuerpos monoclonales para el cáncer de páncreas |
| DE10116552A1 (de) * | 2001-04-03 | 2002-10-10 | Abc Armbruster Biochemicals | Verfahren zur Bestimmung der wirksamen Parathormon-Aktivität in einer Probe |
| WO2004004639A2 (en) * | 2002-07-02 | 2004-01-15 | Smithkline Beecham Corporation | A novel stable formulation |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| EP3524611B1 (en) | 2003-05-20 | 2020-12-30 | ImmunoGen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| EP2468304A3 (en) | 2005-02-11 | 2012-09-26 | ImmunoGen, Inc. | Process for preparing stable drug conjugates |
| US9243062B2 (en) * | 2005-08-11 | 2016-01-26 | Arpi Matossian-Rogers | Peptides for treatment and diagnosis of autoimmune disease |
| AU2012241141B2 (en) * | 2005-08-11 | 2015-08-20 | Arpi Matossian-Rogers | TCR-V-beta related peptides for treatment and diagnosis of autoimmune disease |
| EP2399609B1 (en) | 2005-08-24 | 2015-03-18 | ImmunoGen, Inc. | Process for preparing maytansinoid antibody conjugates |
| WO2010016527A1 (ja) | 2008-08-05 | 2010-02-11 | 東レ株式会社 | 癌の検出方法 |
| RU2595424C2 (ru) | 2009-06-03 | 2016-08-27 | Иммьюноджен, Инк. | Способы конъюгации |
| KR102272828B1 (ko) | 2011-03-29 | 2021-07-05 | 이뮤노젠 아이엔씨 | 일-단계 방법에 의한 메이탄시노이드 항체 접합체의 제조 |
| WO2012135517A2 (en) | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Preparation of maytansinoid antibody conjugates by a one-step process |
| CN105209592A (zh) | 2012-10-04 | 2015-12-30 | 伊缪诺金公司 | 使用pvdf膜纯化细胞结合剂细胞毒性剂缀合物 |
| WO2015076425A1 (ja) * | 2013-11-25 | 2015-05-28 | リンク・ジェノミクス株式会社 | 新規モノクローナル抗体 |
| WO2016081584A1 (en) | 2014-11-19 | 2016-05-26 | Immunogen, Inc. | Process for preparing cell-binding agent-cytotoxic agent conjugates |
| MX2018008383A (es) | 2016-01-10 | 2019-05-30 | Neotx Therapeutics Ltd | Inmunoterapia contra el cáncer mediada por superantígeno mejorada por inmunopotenciador. |
| JP2019510741A (ja) | 2016-02-05 | 2019-04-18 | イミュノジェン・インコーポレーテッド | 細胞結合剤・細胞毒性剤コンジュゲートを調製するための効率的なプロセス |
| CN107167590B (zh) * | 2017-04-14 | 2019-03-08 | 江苏福隆生物技术有限公司 | 糖类抗原242的板式化学发光法检测试剂盒及制备方法 |
| US20200256880A1 (en) * | 2017-08-16 | 2020-08-13 | The Broad Institute, Inc. | Neuronal Assay Method Involving Calcineurin |
| JP2022531978A (ja) | 2019-05-15 | 2022-07-12 | ネオティーエックス セラピューティクス リミテッド | 癌治療 |
| US20230085724A1 (en) | 2020-03-05 | 2023-03-23 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752569A (en) * | 1984-06-21 | 1988-06-21 | The Regents Of The University Of California | Sialylated Lewisx epitope, antibodies and diagnosis |
| US4904596A (en) * | 1985-08-07 | 1990-02-27 | Fred Hutchinson Cancer Research Center | Hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside |
| SE8902043L (sv) * | 1988-11-10 | 1990-05-11 | Pharmacia Ab | Foerfarande foer karakterisering av makromolekyler |
| AU656906B2 (en) * | 1990-07-20 | 1995-02-23 | Active Biotech Ab | Target specific antibody-superantigen conjugates and their preparation |
| AU657483B2 (en) * | 1990-07-20 | 1995-03-16 | Pharmacia Ab | Heterobifunctional reagents and conjugates with oxaalkylene units for amphiphilic bridge structures |
-
1991
- 1991-07-03 SE SE9102074A patent/SE9102074D0/xx unknown
-
1992
- 1992-07-02 WO PCT/SE1992/000495 patent/WO1993001302A1/en not_active Ceased
- 1992-07-02 IL IL10239092A patent/IL102390A/en not_active IP Right Cessation
- 1992-07-03 IE IE922188A patent/IE80841B1/en not_active IP Right Cessation
- 1992-07-03 AU AU19425/92A patent/AU658198B2/en not_active Ceased
- 1992-07-03 ES ES92850166T patent/ES2124250T3/es not_active Expired - Lifetime
- 1992-07-03 NZ NZ243435A patent/NZ243435A/en not_active IP Right Cessation
- 1992-07-03 KR KR1019930704117A patent/KR100246681B1/ko not_active Expired - Fee Related
- 1992-07-03 WO PCT/SE1992/000502 patent/WO1993001303A1/en not_active Ceased
- 1992-07-03 HU HU9400011A patent/HU218084B/hu not_active IP Right Cessation
- 1992-07-03 CA CA002073124A patent/CA2073124C/en not_active Expired - Lifetime
- 1992-07-03 EP EP92850166A patent/EP0521842B1/en not_active Expired - Lifetime
- 1992-07-03 JP JP17584892A patent/JP3194020B2/ja not_active Expired - Lifetime
- 1992-07-03 DK DK92850166T patent/DK0521842T3/da active
- 1992-07-03 AT AT92850166T patent/ATE171193T1/de not_active IP Right Cessation
- 1992-07-03 DE DE69226990T patent/DE69226990T2/de not_active Expired - Lifetime
- 1992-07-03 AU AU22920/92A patent/AU2292092A/en not_active Abandoned
-
1993
- 1993-12-22 NO NO19934777A patent/NO315472B1/no unknown
- 1993-12-31 FI FI935970A patent/FI109207B/fi not_active IP Right Cessation
-
1994
- 1994-11-16 EE EE9400328A patent/EE03031B1/xx not_active IP Right Cessation
-
1995
- 1995-05-08 US US08/438,123 patent/US5552293A/en not_active Expired - Lifetime
- 1995-06-20 HU HU95P/P00289P patent/HU211512A9/hu unknown
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