JP3001983B2 - Ｇ−タンパク質機能の阻害および増殖性疾患の処置のために有用な三環式カーバメート化合物 - Google Patents

Ｇ−タンパク質機能の阻害および増殖性疾患の処置のために有用な三環式カーバメート化合物

Info

Publication number
JP3001983B2
JP3001983B2 JP8529432A JP52943296A JP3001983B2 JP 3001983 B2 JP3001983 B2 JP 3001983B2 JP 8529432 A JP8529432 A JP 8529432A JP 52943296 A JP52943296 A JP 52943296A JP 3001983 B2 JP3001983 B2 JP 3001983B2
Authority
JP
Japan
Prior art keywords
cells
inhibiting
compounds
compound
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP8529432A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10505103A (ja
Inventor
ダブリュー． ロバート ビショップ，
ロナルド ジェイ． ドール，
アラン ケイ． マラムズ，
エフ． ジョージ ンジョロジ，
ジョアン エム． ペトリン，
ジョン ジェイ． ピウィンスキー，
ロナルド エル． ウォリン，
アーサー ジー． タベラス，
ステーシー ダブリュー． レミスゼウスキー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JPH10505103A publication Critical patent/JPH10505103A/ja
Application granted granted Critical
Publication of JP3001983B2 publication Critical patent/JP3001983B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP8529432A 1995-03-24 1996-03-21 Ｇ−タンパク質機能の阻害および増殖性疾患の処置のために有用な三環式カーバメート化合物 Expired - Fee Related JP3001983B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/410,479 1995-03-24
US410,479 1995-03-24
US08/410,479 US5721236A (en) 1993-10-15 1995-03-24 Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
PCT/US1996/003312 WO1996030018A1 (en) 1995-03-24 1996-03-21 Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
JPH10505103A JPH10505103A (ja) 1998-05-19
JP3001983B2 true JP3001983B2 (ja) 2000-01-24

Family

ID=23624909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8529432A Expired - Fee Related JP3001983B2 (ja) 1995-03-24 1996-03-21 Ｇ−タンパク質機能の阻害および増殖性疾患の処置のために有用な三環式カーバメート化合物

Country Status (15)

Country Link
US (4) US5721236A (https=)
EP (1) EP0817632B1 (https=)
JP (1) JP3001983B2 (https=)
KR (1) KR19980703250A (https=)
AR (1) AR001413A1 (https=)
AT (1) ATE232101T1 (https=)
AU (1) AU714308B2 (https=)
CA (1) CA2216231C (https=)
DE (1) DE69626104T2 (https=)
ES (1) ES2187642T3 (https=)
IL (1) IL117601A0 (https=)
MX (1) MX9707192A (https=)
NZ (1) NZ304641A (https=)
TW (1) TW323278B (https=)
WO (1) WO1996030018A1 (https=)

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ATE232101T1 (de) 2003-02-15
IL117601A0 (en) 1996-07-23
EP0817632A1 (en) 1998-01-14
AU714308B2 (en) 1999-12-23
JPH10505103A (ja) 1998-05-19
AR001413A1 (es) 1997-10-22
DE69626104T2 (de) 2003-11-27
DE69626104D1 (de) 2003-03-13
CA2216231C (en) 2001-07-03
AU5189196A (en) 1996-10-16
NZ304641A (en) 1999-04-29
CA2216231A1 (en) 1996-10-03
US6300338B1 (en) 2001-10-09
US5977128A (en) 1999-11-02
US5721236A (en) 1998-02-24
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US5728703A (en) 1998-03-17
EP0817632B1 (en) 2003-02-05
ES2187642T3 (es) 2003-06-16

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