JP2944048B2 - 二環式テトラヒドロピラゾロピリジン - Google Patents
二環式テトラヒドロピラゾロピリジンInfo
- Publication number
- JP2944048B2 JP2944048B2 JP7503938A JP50393895A JP2944048B2 JP 2944048 B2 JP2944048 B2 JP 2944048B2 JP 7503938 A JP7503938 A JP 7503938A JP 50393895 A JP50393895 A JP 50393895A JP 2944048 B2 JP2944048 B2 JP 2944048B2
- Authority
- JP
- Japan
- Prior art keywords
- ethyl
- oxo
- pyridine
- tetrahydro
- pyrazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8829293A | 1993-07-06 | 1993-07-06 | |
US08/088,292 | 1993-07-06 | ||
US088,292 | 1993-07-06 | ||
PCT/IB1994/000156 WO1995001980A1 (en) | 1993-07-06 | 1994-06-16 | Bicyclic tetrahydro pyrazolopyridines |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08507084A JPH08507084A (ja) | 1996-07-30 |
JP2944048B2 true JP2944048B2 (ja) | 1999-08-30 |
Family
ID=22210524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7503938A Expired - Lifetime JP2944048B2 (ja) | 1993-07-06 | 1994-06-16 | 二環式テトラヒドロピラゾロピリジン |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0707585A1 (zh) |
JP (1) | JP2944048B2 (zh) |
KR (1) | KR100228949B1 (zh) |
CN (1) | CN1048015C (zh) |
AU (1) | AU695301B2 (zh) |
BR (1) | BR9406946A (zh) |
CA (1) | CA2166721C (zh) |
CZ (1) | CZ3696A3 (zh) |
EG (1) | EG20513A (zh) |
FI (1) | FI943208A (zh) |
HU (1) | HUT74170A (zh) |
IL (1) | IL110175A (zh) |
MX (1) | MX9405132A (zh) |
NO (1) | NO305029B1 (zh) |
NZ (1) | NZ266525A (zh) |
PL (1) | PL312426A1 (zh) |
RU (1) | RU2131876C1 (zh) |
TW (1) | TW316904B (zh) |
WO (1) | WO1995001980A1 (zh) |
ZA (1) | ZA944844B (zh) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ292991A (en) * | 1994-10-20 | 1999-02-25 | Pfizer | Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them |
CA2223624C (en) * | 1995-06-06 | 2001-02-20 | Pfizer Inc. | Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines |
AP932A (en) * | 1996-08-26 | 2001-02-02 | Pfizer | Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines. |
TR199900481T2 (xx) * | 1996-09-04 | 1999-06-21 | Pfizer Inc. | �ndazol t�revleri; fosfodiesteraz tip IV inhibit�rleri olarak kullan�mlar�. |
US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
SI1140941T1 (en) | 1998-12-23 | 2005-04-30 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor xa inhibitors |
US6326495B2 (en) | 1999-04-30 | 2001-12-04 | Pfizer Inc. | Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein |
EA006685B1 (ru) | 1999-08-21 | 2006-02-24 | Алтана Фарма Аг | Синергетическая композиция |
TWI243055B (en) * | 2000-04-13 | 2005-11-11 | Nippon Zoki Pharmaceutical Co | Pharmaceutical composition for use in treatment of dermatitis |
AU2001287654B2 (en) * | 2000-08-10 | 2006-12-14 | Pfizer Italia S.R.I. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
US6960595B2 (en) * | 2001-03-23 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | 5-6 to 5-7 Heterobicycles as factor Xa inhibitors |
US6706730B2 (en) | 2001-04-18 | 2004-03-16 | Bristol-Myers Squibb Pharma Company | 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors |
CA2444571A1 (en) | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as factor xa inhi bitors |
WO2002088122A1 (fr) * | 2001-04-26 | 2002-11-07 | Ajinomoto Co., Inc. | Composes heterocycliques |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2004076450A1 (en) | 2003-02-27 | 2004-09-10 | J. Uriach Y Compañia S.A. | Pyrazolopyridine derivates |
US7135469B2 (en) * | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
KR20050115331A (ko) | 2003-04-01 | 2005-12-07 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 불임증 포스포디에스터라제의 억제제 |
US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
DE102005031580A1 (de) * | 2005-07-06 | 2007-01-11 | Aicuris Gmbh & Co. Kg | Substituierte Sulfolanylpyrazole und ihre Verwendung |
AR065804A1 (es) * | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
CN110357888A (zh) * | 2018-04-09 | 2019-10-22 | 南京药捷安康生物科技有限公司 | 杂环磷酸二酯酶抑制剂及其用途 |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3340269A (en) * | 1964-09-08 | 1967-09-05 | Ciba Geigy Corp | 1-substituted 4-acyl-2, 3-dioxo-piperidine |
US3365459A (en) * | 1964-09-08 | 1968-01-23 | Ciba Geigy Corp | Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives |
FR1463883A (fr) * | 1964-09-08 | 1966-07-22 | Ciba Geigy | Procédé de préparation de triaza-composés bicycliques |
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
-
1994
- 1994-06-16 RU RU96103653A patent/RU2131876C1/ru active
- 1994-06-16 NZ NZ266525A patent/NZ266525A/en unknown
- 1994-06-16 KR KR1019960700019A patent/KR100228949B1/ko not_active IP Right Cessation
- 1994-06-16 HU HU9503934A patent/HUT74170A/hu unknown
- 1994-06-16 CA CA002166721A patent/CA2166721C/en not_active Expired - Fee Related
- 1994-06-16 BR BR9406946A patent/BR9406946A/pt not_active Application Discontinuation
- 1994-06-16 CN CN94193233A patent/CN1048015C/zh not_active Expired - Fee Related
- 1994-06-16 PL PL94312426A patent/PL312426A1/xx unknown
- 1994-06-16 WO PCT/IB1994/000156 patent/WO1995001980A1/en not_active Application Discontinuation
- 1994-06-16 EP EP94916370A patent/EP0707585A1/en not_active Withdrawn
- 1994-06-16 AU AU68057/94A patent/AU695301B2/en not_active Ceased
- 1994-06-16 CZ CZ9636A patent/CZ3696A3/cs unknown
- 1994-06-16 JP JP7503938A patent/JP2944048B2/ja not_active Expired - Lifetime
- 1994-06-17 TW TW083105518A patent/TW316904B/zh active
- 1994-06-30 IL IL11017594A patent/IL110175A/xx active IP Right Grant
- 1994-07-05 MX MX9405132A patent/MX9405132A/es unknown
- 1994-07-05 FI FI943208A patent/FI943208A/fi unknown
- 1994-07-05 ZA ZA944844A patent/ZA944844B/xx unknown
- 1994-07-05 EG EG40294A patent/EG20513A/xx active
-
1996
- 1996-01-05 NO NO960056A patent/NO305029B1/no unknown
Non-Patent Citations (1)
Title |
---|
Chen,Pharm,Bull,24(8),1870〜8(1976) |
Also Published As
Publication number | Publication date |
---|---|
MX9405132A (es) | 1995-01-31 |
NO305029B1 (no) | 1999-03-22 |
IL110175A (en) | 2000-01-31 |
CN1129940A (zh) | 1996-08-28 |
WO1995001980A1 (en) | 1995-01-19 |
KR960703852A (ko) | 1996-08-31 |
AU695301B2 (en) | 1998-08-13 |
CA2166721C (en) | 1999-07-27 |
BR9406946A (pt) | 1996-08-06 |
IL110175A0 (en) | 1994-10-07 |
HU9503934D0 (en) | 1996-03-28 |
NO960056D0 (no) | 1996-01-05 |
PL312426A1 (en) | 1996-04-29 |
FI943208A0 (fi) | 1994-07-05 |
EG20513A (en) | 1999-06-30 |
CA2166721A1 (en) | 1995-01-19 |
CN1048015C (zh) | 2000-01-05 |
HUT74170A (en) | 1996-11-28 |
CZ3696A3 (en) | 1997-06-11 |
RU2131876C1 (ru) | 1999-06-20 |
ZA944844B (en) | 1996-01-05 |
JPH08507084A (ja) | 1996-07-30 |
NZ266525A (en) | 1997-10-24 |
AU6805794A (en) | 1995-02-06 |
TW316904B (zh) | 1997-10-01 |
FI943208A (fi) | 1995-01-07 |
EP0707585A1 (en) | 1996-04-24 |
NO960056L (no) | 1996-01-05 |
KR100228949B1 (ko) | 1999-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2944048B2 (ja) | 二環式テトラヒドロピラゾロピリジン | |
JP3000674B2 (ja) | ジヒドロピラゾロピロール類 | |
JP6289485B2 (ja) | Pde4のヘテロアリール阻害剤 | |
US7589206B2 (en) | Pyrrolopyridine derivatives | |
US6492520B1 (en) | Substituted pyrido-or pyrimido-containing 6,6- or 6,7-bicyclic derivatives | |
JP2891544B2 (ja) | ピラゾロおよびピロロピリジン類 | |
TWI404721B (zh) | 胺基-雜環化合物 | |
JP4790703B2 (ja) | 環式化合物 | |
EP1296981B1 (en) | Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors | |
JP3152940B2 (ja) | ホスホジエステラーゼ(pde)iv型および腫瘍壊死因子(tnf)阻害物質としての置換インダゾール誘導体及びその使用法 | |
US6127398A (en) | Substituted indazole derivatives and related compounds | |
JPH09511758A (ja) | 二環式テトラヒドロピラゾロピリジンおよび医薬としてのその使用 | |
JPH08501318A (ja) | 選択的pde▲下i▼▲下v▼阻害物質としてのカテコールジエーテル類 | |
WO2007032466A1 (ja) | 複素環化合物、その製造方法並びに用途 | |
JP6506833B2 (ja) | イミダゾピリダジン化合物 | |
KR20080058456A (ko) | 비만, 정신 질환 및 신경 질환의 치료를 위한테트라히드로피롤로[3,2-c]피리딘-4-온 유도체의 제조 및용도 | |
AU2014220351A1 (en) | Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of CNS and other disorders | |
JP3939246B2 (ja) | インドロキナゾリノン類 | |
WO2018019222A1 (zh) | 作为jak抑制剂杂环化合物,该化合物的盐类及其治疗用途 | |
KR20150036561A (ko) | 디플루오로메틸렌 화합물 | |
JP2009525306A (ja) | 化合物 | |
JP2008530211A (ja) | ケモカイン受容体のモジュレーターとなる置換ピラゾール | |
CA2201728A1 (en) | Bicyclic tetrahydro pyrazolopyridines and their use as medicaments |