JP2818097B2 - アゾール化合物、その製造方法及びその用途 - Google Patents

アゾール化合物、その製造方法及びその用途

Info

Publication number
JP2818097B2
JP2818097B2 JP5101216A JP10121693A JP2818097B2 JP 2818097 B2 JP2818097 B2 JP 2818097B2 JP 5101216 A JP5101216 A JP 5101216A JP 10121693 A JP10121693 A JP 10121693A JP 2818097 B2 JP2818097 B2 JP 2818097B2
Authority
JP
Japan
Prior art keywords
difluorophenyl
group
salt
phenyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP5101216A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06293740A (ja
Inventor
克己 伊藤
研二 小此木
典一 田村
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Priority to JP5101216A priority Critical patent/JP2818097B2/ja
Priority to MYPI93001631A priority patent/MY109672A/en
Priority to MX9305295A priority patent/MX9305295A/es
Publication of JPH06293740A publication Critical patent/JPH06293740A/ja
Application granted granted Critical
Publication of JP2818097B2 publication Critical patent/JP2818097B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerization Catalysts (AREA)
  • Coloring (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Lubricants (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Steroid Compounds (AREA)
JP5101216A 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途 Expired - Fee Related JP2818097B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP5101216A JP2818097B2 (ja) 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途
MYPI93001631A MY109672A (en) 1993-02-10 1993-08-17 Azole compounds, their production and use
MX9305295A MX9305295A (es) 1993-02-10 1993-08-31 Compuestos azol y proceso para su preparacion.

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP4-110400 1992-04-28
JP11040092 1992-04-28
JP2262393 1993-02-10
JP5-22623 1993-02-10
JP5101216A JP2818097B2 (ja) 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途

Publications (2)

Publication Number Publication Date
JPH06293740A JPH06293740A (ja) 1994-10-21
JP2818097B2 true JP2818097B2 (ja) 1998-10-30

Family

ID=26359882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5101216A Expired - Fee Related JP2818097B2 (ja) 1992-04-28 1993-04-27 アゾール化合物、その製造方法及びその用途

Country Status (18)

Country Link
US (2) US5371101A (https=)
EP (1) EP0567982B1 (https=)
JP (1) JP2818097B2 (https=)
KR (1) KR100257619B1 (https=)
CN (1) CN1040433C (https=)
AT (1) ATE167857T1 (https=)
AU (1) AU655544B2 (https=)
CA (1) CA2094962A1 (https=)
DE (1) DE69319380T2 (https=)
DK (1) DK0567982T3 (https=)
ES (1) ES2118160T3 (https=)
FI (1) FI931901L (https=)
HU (2) HUT64327A (https=)
NO (1) NO303284B1 (https=)
NZ (1) NZ247488A (https=)
PH (1) PH31082A (https=)
SG (1) SG48939A1 (https=)
TW (1) TW218017B (https=)

Families Citing this family (52)

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HU212458B (en) * 1993-09-23 1996-06-28 Richter Gedeon Vegyeszet New silyloxypropane derivatives substituted with triazole or imidazole pharmaceutical compositions containing them and process for producing them
TW297813B (https=) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) * 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
FI963297L (fi) * 1994-02-25 1996-10-18 Takeda Chemical Industries Ltd Antifungaalisia triatsolijohdannaisia sisältävät emulsiot
US5677464A (en) * 1994-05-31 1997-10-14 Takeda Chemical Industries, Ltd. Production of optically active triazole compounds and their intermediates
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
WO1996025410A1 (en) * 1995-02-17 1996-08-22 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
TW318841B (https=) * 1995-02-17 1997-11-01 Takeda Pharm Industry Co Ltd
US5700825A (en) * 1995-03-31 1997-12-23 Florida State University Radiosensitizing diamines and their pharmaceutical preparations
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
DE19520597A1 (de) * 1995-06-06 1996-12-12 Bayer Ag Mercapto-bis-triazole
ES2107376B1 (es) * 1995-08-02 1998-07-01 Uriach & Cia Sa J Nuevos derivados de pirimidona con actividad antifungica.
BR9606547A (pt) * 1995-08-02 1997-10-14 Uriach & Cia Sa J Novos derivados de pirimidona com atividade fungicida
BR9606546A (pt) * 1995-08-02 1998-07-14 Uriach & Cia Sa J Novas carboxamidas com atividade fungicida
ES2120885B1 (es) * 1996-03-15 1999-06-16 Uriach & Cia Sa J Nuevas tienopirimidonas con actividad antifungica.
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1998039305A1 (en) * 1997-03-05 1998-09-11 Takeda Chemical Industries, Ltd. Crystalline form of a bis 1,2,4-triazole compound
CN1251098A (zh) 1997-03-31 2000-04-19 武田药品工业株式会社 吡咯化合物,其制备及其用途
EP0884311A3 (en) * 1997-06-06 1999-01-27 Takeda Chemical Industries, Ltd. Triazole Derivatives and their production
US6133485A (en) * 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
EP1120116A1 (en) * 1998-09-29 2001-08-01 Takeda Chemical Industries, Ltd. Antimycotic drug composition
ES2159488B1 (es) 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
IN191188B (https=) 2000-03-07 2003-10-04 Ranbaxy Lab Ltd
PL365072A1 (en) * 2000-03-07 2004-12-27 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
MXPA03005899A (es) 2000-12-26 2004-01-26 Ranbaxy Lab Ltd Compuestos azoles como agentes anti-micoticos.
DE60114889T2 (de) * 2001-03-23 2006-07-20 Richter Gedeon Vegyészeti Gyár R.T. Verfahren zur herstellung von fluconazole und kristallmodifikationen davon
IN191819B (https=) * 2001-07-19 2004-01-03 Ranbaxy Lab Ltd
IN192526B (https=) * 2001-09-25 2004-04-24 Ranbaxy Lab
US7028055B2 (en) * 2002-03-22 2006-04-11 Sun Microsystems, Inc. Method and apparatus for improving transaction specification by marking application states
MXPA04010066A (es) * 2002-04-12 2004-12-13 Ranbaxy Lab Ltd Derivados de tetrahidrofurano 2,2,4-trisubstituido como agentes antifungicos.
JPWO2003105841A1 (ja) * 2002-06-18 2005-10-13 ポーラ化成工業株式会社 抗真菌医薬組成物
WO2004018485A1 (en) * 2002-08-26 2004-03-04 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
EP1817295B1 (en) 2004-11-18 2012-11-07 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
CN1304376C (zh) * 2005-03-04 2007-03-14 清华大学 一种卤化烷基咪唑型离子液体的制备方法
US7608635B2 (en) * 2005-08-12 2009-10-27 Synta Pharmaceuticals Corp. Pyrazole compounds that modulate HSP90 activity
JP5118039B2 (ja) * 2005-08-18 2013-01-16 シンタ ファーマシューティカルズ コーポレーション Ｈｓｐ９０活性を調節するトリアゾール化合物
CA2653327A1 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Compounds that modulate hsp90 activity and methods for identifying same
WO2007139955A2 (en) * 2006-05-25 2007-12-06 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
EP2038262B1 (en) * 2006-05-25 2014-11-12 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
SI2035396T1 (sl) * 2006-05-25 2014-08-29 Synta Pharmaceuticals Corp. Triazolne spojine, ki modulirajo aktivnost HSP90
WO2008021049A2 (en) 2006-08-07 2008-02-21 Stiefel Laboratories, Inc. Crystalline antifungal compounds
CN101553474B (zh) * 2006-10-19 2013-02-27 霍夫曼-拉罗奇有限公司 作为糖尿病用11b-HSD1抑制剂的咪唑啉酮和咪唑烷酮衍生物
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CN102824342B (zh) * 2011-06-17 2016-03-30 全哲山 一类用作抗癫痫药的化合物及其可药用盐
CA2853799A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
JP2014534228A (ja) 2011-11-02 2014-12-18 シンタ ファーマシューティカルズ コーポレーション 白金含有剤とｈｓｐ９０阻害剤の組合せ療法
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
DK159205C (da) * 1983-03-16 1991-03-04 Pfizer Bis(triazol)alkanol-forbindelser, anvendelse af disse, farmaceutiske praeparater og landbrugsfungicider indeholdende disse og fremgangsmaade til behandling af planter eller froe, som har en svampeinfektion
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
DK105189A (da) * 1988-03-04 1989-09-05 Sankyo Co Triazolderivater og fremgangsmaade til fremstilling deraf samt fungicide midler indeholdende derivaterne
DE3837463A1 (de) * 1988-11-04 1990-05-10 Bayer Ag Substituierte bisazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
CN1040433C (zh) 1998-10-28
TW218017B (https=) 1993-12-21
DE69319380D1 (de) 1998-08-06
DK0567982T3 (da) 1999-04-12
AU655544B2 (en) 1994-12-22
CA2094962A1 (en) 1993-10-29
DE69319380T2 (de) 1998-10-29
ES2118160T3 (es) 1998-09-16
HU9301226D0 (en) 1993-07-28
SG48939A1 (en) 1998-05-18
AU3822193A (en) 1993-11-04
NO931533D0 (no) 1993-04-27
EP0567982B1 (en) 1998-07-01
JPH06293740A (ja) 1994-10-21
FI931901A7 (fi) 1993-10-29
HUT64327A (en) 1993-12-28
KR100257619B1 (en) 2000-07-01
US5466820A (en) 1995-11-14
PH31082A (en) 1998-02-05
FI931901L (fi) 1993-10-29
US5371101A (en) 1994-12-06
ATE167857T1 (de) 1998-07-15
KR940005616A (ko) 1994-03-21
HU211474A9 (en) 1995-11-28
FI931901A0 (fi) 1993-04-27
NO303284B1 (no) 1998-06-22
NZ247488A (en) 1995-02-24
CN1079467A (zh) 1993-12-15
EP0567982A1 (en) 1993-11-03
NO931533L (no) 1993-10-29

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Legal Events

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A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 19980721

LAPS Cancellation because of no payment of annual fees