JP2025000750A5 - - Google Patents
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- JP2025000750A5 JP2025000750A5 JP2024165838A JP2024165838A JP2025000750A5 JP 2025000750 A5 JP2025000750 A5 JP 2025000750A5 JP 2024165838 A JP2024165838 A JP 2024165838A JP 2024165838 A JP2024165838 A JP 2024165838A JP 2025000750 A5 JP2025000750 A5 JP 2025000750A5
- Authority
- JP
- Japan
- Prior art keywords
- aav vector
- composition
- subject
- vector according
- aav
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025199231A JP2026020285A (ja) | 2019-02-08 | 2025-11-19 | ミオシン１５プロモーター及びその使用 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962802874P | 2019-02-08 | 2019-02-08 | |
| US62/802,874 | 2019-02-08 | ||
| US201962928311P | 2019-10-30 | 2019-10-30 | |
| US62/928,311 | 2019-10-30 | ||
| US202062965773P | 2020-01-24 | 2020-01-24 | |
| US62/965,773 | 2020-01-24 | ||
| PCT/US2020/017292 WO2020163761A1 (en) | 2019-02-08 | 2020-02-07 | Myosin 15 promoters and uses thereof |
| JP2021546388A JP7562544B2 (ja) | 2019-02-08 | 2020-02-07 | ミオシン１５プロモーター及びその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546388A Division JP7562544B2 (ja) | 2019-02-08 | 2020-02-07 | ミオシン１５プロモーター及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025199231A Division JP2026020285A (ja) | 2019-02-08 | 2025-11-19 | ミオシン１５プロモーター及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025000750A JP2025000750A (ja) | 2025-01-07 |
| JP2025000750A5 true JP2025000750A5 (https=) | 2025-03-31 |
| JP7778879B2 JP7778879B2 (ja) | 2025-12-02 |
Family
ID=71947522
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546388A Active JP7562544B2 (ja) | 2019-02-08 | 2020-02-07 | ミオシン１５プロモーター及びその使用 |
| JP2024165838A Active JP7778879B2 (ja) | 2019-02-08 | 2024-09-25 | ミオシン１５プロモーター及びその使用 |
| JP2025199231A Pending JP2026020285A (ja) | 2019-02-08 | 2025-11-19 | ミオシン１５プロモーター及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546388A Active JP7562544B2 (ja) | 2019-02-08 | 2020-02-07 | ミオシン１５プロモーター及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025199231A Pending JP2026020285A (ja) | 2019-02-08 | 2025-11-19 | ミオシン１５プロモーター及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US12252520B2 (https=) |
| EP (1) | EP3920974A4 (https=) |
| JP (3) | JP7562544B2 (https=) |
| CN (3) | CN119320772A (https=) |
| AU (1) | AU2020218547A1 (https=) |
| CA (1) | CA3129422A1 (https=) |
| WO (1) | WO2020163761A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CN119410636A (zh) | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| CA3159549A1 (en) * | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| JP7807380B2 (ja) | 2020-02-21 | 2026-01-27 | アコーオス インコーポレイテッド | ヒト対象において非加齢関連聴力障害を処置するための組成物および方法 |
| CN112194717B (zh) * | 2020-09-30 | 2021-12-14 | 东南大学 | 一种促进耳蜗毛细胞再生的肽段Tr及其应用 |
| JP2025504263A (ja) | 2021-12-23 | 2025-02-10 | ユニバーシティ オブ ロチェスター | 内耳への薬剤の送達のためのｃｓｆ輸送経路 |
| JP2025503508A (ja) | 2021-12-23 | 2025-02-04 | ユニバーシティ オブ ロチェスター | 内耳への薬剤の送達のための組成物及び方法 |
| CN116836975A (zh) * | 2022-03-25 | 2023-10-03 | 上海玮美基因科技有限责任公司 | 一种耳蜗和/或前庭细胞特异性启动子及其应用 |
| WO2024250774A1 (zh) * | 2023-06-07 | 2024-12-12 | 苏州星奥拓维生物技术有限公司 | 耳蜗外毛细胞特异性启动子及其应用 |
| CN117486995A (zh) * | 2023-11-03 | 2024-02-02 | 首都医科大学附属北京胸科医院 | Kncn蛋白在结核诊断试剂中的应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| US6436392B1 (en) | 1998-05-20 | 2002-08-20 | University Of Iowa Research Foundation | Adeno-associated virus vectors |
| EP1224313A1 (en) | 1999-10-07 | 2002-07-24 | University of Iowa Research Foundation | Adeno-associated viruses and uses thereof |
| WO2001029243A1 (en) | 1999-10-15 | 2001-04-26 | Dalhousie University | Method and vector for producing and transferring trans-spliced peptides |
| US20040072154A1 (en) * | 2000-12-22 | 2004-04-15 | Morris David W. | Novel compositions and methods for cancer |
| JP2003088388A (ja) * | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長ｃＤＮＡ |
| US20060024278A1 (en) * | 2004-01-23 | 2006-02-02 | The General Hospital Corporation | Methods and products related to the production of inner ear hair cells |
| US20070161031A1 (en) * | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
| US8298818B2 (en) | 2006-04-28 | 2012-10-30 | University Of Florida Research Foundation, Inc. | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter |
| JP5575486B2 (ja) | 2007-01-18 | 2014-08-20 | ユニヴァーシティ オブ ミズーリー−コロンビア | 筋鞘にｎＮＯＳを回復させる合成ミニ／ミクロジストロフィン遺伝子 |
| FR2919305B1 (fr) | 2007-07-26 | 2009-09-18 | Genethon Ass Loi De 1901 | Vecteurs viraux adeno-associes pour l'expression de la dysferline. |
| EP2732819B1 (en) | 2008-02-07 | 2019-10-16 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
| US8236557B2 (en) | 2008-05-28 | 2012-08-07 | University Of Missouri-Columbia | Hybrid-AAV vectors to deliver large gene expression cassette |
| US8962314B2 (en) | 2008-11-26 | 2015-02-24 | The Regents Of The University Of California | Lateral ventricle cell compositions and use for treating neural degenerative diseases |
| HRP20190144T1 (hr) | 2010-04-23 | 2019-03-22 | University Of Florida Research Foundation, Inc. | Pripravci raav-gvanilat ciklaze i postupci za liječenje leberove urođene amauroze-1 (lca1) |
| WO2013075008A1 (en) | 2011-11-16 | 2013-05-23 | University Of Florida Research Foundation Inc. | Aav dual vector systems for gene therapy |
| EP2802657B1 (en) * | 2012-01-12 | 2018-05-02 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
| US20150050354A1 (en) * | 2012-04-02 | 2015-02-19 | Moderna Therapeutics, Inc. | Modified polynucleotides for the treatment of otic diseases and conditions |
| AU2013249202B2 (en) | 2012-04-18 | 2018-08-09 | The Children's Hospital Of Philadelphia | Composition and methods for highly efficient gene transfer using AAV capsid variants |
| CA2884309A1 (en) * | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity |
| CA2909733C (en) | 2013-04-18 | 2023-10-17 | Fondazione Telethon | Effective delivery of large genes by dual aav vectors |
| KR102234672B1 (ko) | 2013-05-21 | 2021-04-06 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 캡시드-변형된 raav3 벡터 조성물, 및 인간 간암의 유전자 요법에서의 용도 |
| US10751385B2 (en) | 2015-02-20 | 2020-08-25 | Institut Pasteur | Prevention and/or treatment of hearing loss or impairment |
| RS63416B1 (sr) | 2015-03-03 | 2022-08-31 | Fond Telethon | Sistem višestrukih vektora i njegove primene |
| SG11201804814YA (en) | 2015-12-11 | 2018-07-30 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| WO2017108931A1 (en) | 2015-12-22 | 2017-06-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Improved hybrid dual recombinant aav vector systems for gene therapy |
| JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| WO2018145111A1 (en) | 2017-02-06 | 2018-08-09 | Children's Medical Center Corporation | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| AU2018261769B2 (en) | 2017-05-05 | 2024-03-14 | The Regents Of The University Of California | Compositions and methods for expressing Otoferlin |
| DE102018103924A1 (de) | 2018-02-21 | 2019-08-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Gentherapeutische Behandlung von Schwerhörigkeit |
| IL325122A (en) | 2018-02-22 | 2026-02-01 | Akouos Inc | Compositions and methods for treating non-age-related hearing impairment in humans |
| CN119410636A (zh) * | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| US11660353B2 (en) * | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| US12188041B2 (en) | 2018-11-01 | 2025-01-07 | University Of Florida Research Foundation, Incorporated | Codon optimized otoferlin AAV dual vector gene therapy |
| CN118497276A (zh) | 2018-11-07 | 2024-08-16 | 阿库斯股份有限公司 | 腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途 |
| WO2020148458A1 (en) | 2019-01-18 | 2020-07-23 | Institut Pasteur | Aav-mediated gene therapy restoring the otoferlin gene |
| JP2022522995A (ja) | 2019-01-18 | 2022-04-21 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖ粒子を生成するための方法及びシステム |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| CA3159549A1 (en) | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CN117295529A (zh) | 2021-02-19 | 2023-12-26 | 分贝治疗公司 | 使用耳畸蛋白双载体系统治疗感觉神经性听力损失的方法 |
| EP4665751A2 (en) | 2023-02-17 | 2025-12-24 | Decibel Therapeutics, Inc. | Methods and compositions for administering otoferlin dual vector systems |
-
2020
- 2020-02-07 AU AU2020218547A patent/AU2020218547A1/en active Pending
- 2020-02-07 WO PCT/US2020/017292 patent/WO2020163761A1/en not_active Ceased
- 2020-02-07 JP JP2021546388A patent/JP7562544B2/ja active Active
- 2020-02-07 CN CN202411436607.4A patent/CN119320772A/zh active Pending
- 2020-02-07 CN CN202411436605.5A patent/CN119307494A/zh active Pending
- 2020-02-07 EP EP20751991.9A patent/EP3920974A4/en active Pending
- 2020-02-07 CN CN202080026444.6A patent/CN114072179B/zh active Active
- 2020-02-07 CA CA3129422A patent/CA3129422A1/en active Pending
-
2021
- 2021-08-06 US US17/395,773 patent/US12252520B2/en active Active
-
2024
- 2024-09-25 JP JP2024165838A patent/JP7778879B2/ja active Active
-
2025
- 2025-02-26 US US19/063,826 patent/US20250304637A1/en active Pending
- 2025-11-19 JP JP2025199231A patent/JP2026020285A/ja active Pending
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