JP2023532663A5 - - Google Patents
Info
- Publication number
- JP2023532663A5 JP2023532663A5 JP2022580043A JP2022580043A JP2023532663A5 JP 2023532663 A5 JP2023532663 A5 JP 2023532663A5 JP 2022580043 A JP2022580043 A JP 2022580043A JP 2022580043 A JP2022580043 A JP 2022580043A JP 2023532663 A5 JP2023532663 A5 JP 2023532663A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- ires
- protein
- acid sequence
- circular rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063043964P | 2020-06-25 | 2020-06-25 | |
| US63/043,964 | 2020-06-25 | ||
| US202163186507P | 2021-05-10 | 2021-05-10 | |
| US63/186,507 | 2021-05-10 | ||
| PCT/US2021/039127 WO2021263124A2 (en) | 2020-06-25 | 2021-06-25 | Genetic elements driving circular rna translation and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023532663A JP2023532663A (ja) | 2023-07-31 |
| JP2023532663A5 true JP2023532663A5 (https=) | 2024-07-02 |
Family
ID=79281918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022580043A Pending JP2023532663A (ja) | 2020-06-25 | 2021-06-25 | 環状ｒｎａ翻訳を駆動する遺伝エレメント及び使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11560567B2 (https=) |
| EP (1) | EP4171631A4 (https=) |
| JP (1) | JP2023532663A (https=) |
| KR (1) | KR20230028375A (https=) |
| CN (1) | CN116323945A (https=) |
| AU (1) | AU2021297340A1 (https=) |
| CA (1) | CA3180224A1 (https=) |
| WO (1) | WO2021263124A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240299520A1 (en) * | 2021-02-09 | 2024-09-12 | Virginia Commonwealth University | Mini circular rna therapeutics and vaccines and methods of use thereof |
| IL312965A (en) | 2021-11-24 | 2024-07-01 | Flagship Pioneering Innovations Vi Llc | Immunogenic compositions and their uses |
| EP4436984A1 (en) | 2021-11-24 | 2024-10-02 | Flagship Pioneering Innovations VI, LLC | Coronavirus immunogen compositions and their uses |
| CN118401544A (zh) | 2021-11-24 | 2024-07-26 | 旗舰创业创新六公司 | 水痘-带状疱疹病毒免疫原组合物及其用途 |
| KR20240118174A (ko) | 2021-12-17 | 2024-08-02 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 변성 조건 하에서의 원형 rna의 풍부화를 위한 방법 |
| EP4453201A1 (en) | 2021-12-22 | 2024-10-30 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for purifying polyribonucleotides |
| KR20240118881A (ko) | 2021-12-23 | 2024-08-05 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 항푸소제닉 폴리펩티드를 인코딩하는 원형 폴리리보뉴클레오티드 |
| CN119095967A (zh) * | 2022-02-24 | 2024-12-06 | 普罗拜奥根股份公司 | 病毒样颗粒介导的环状rna递送 |
| EP4493197A4 (en) * | 2022-03-17 | 2026-03-18 | Univ Leland Stanford Junior | COMPOSITIONS AND METHODS FOR ENHANCED PROTEIN TRANSLATION FROM RECOMBED CIRCULAR RNA |
| US20250320519A1 (en) | 2022-05-30 | 2025-10-16 | Shanghai Circode Biomed Co., Ltd. | Synthetic circular rna compositions and methods of use thereof |
| JP2025519910A (ja) * | 2022-06-24 | 2025-06-26 | ザ・ブロード・インスティテュート・インコーポレイテッド | キャップされた環状ｒｎａ分子を調製するための組成物及び方法 |
| US20260002223A1 (en) * | 2022-06-27 | 2026-01-01 | Wisconsin Alumni Research Foundation | Universal method for parasite and eukaryotic endosymbiont identification |
| KR20240003761A (ko) * | 2022-06-29 | 2024-01-09 | 서울대학교산학협력단 | mRNA 번역 증가용 조절 엘리먼트를 스크리닝하는 방법,상기 방법에 따른 신규 조절 엘리먼트, 및 이의 용도 |
| WO2024010028A1 (ja) * | 2022-07-06 | 2024-01-11 | 国立大学法人京都大学 | 環状ｒｎａ分子及びこれを用いた翻訳制御方法、翻訳活性化システム、並びに医薬組成物 |
| CN115394376B (zh) * | 2022-09-28 | 2023-04-18 | 奥明(杭州)生物医药有限公司 | 一种预测环状rna ires的方法 |
| TW202434728A (zh) | 2022-11-08 | 2024-09-01 | 美商旗艦先鋒創新有限責任公司 | 用於產生環狀多核糖核苷酸的組成物和方法 |
| KR20250122519A (ko) | 2022-12-22 | 2025-08-13 | 젠스크립트 유에스에이 인크. | 자가환형화 rna의 제조 방법 |
| WO2024151583A2 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
| CN121057577A (zh) | 2023-01-27 | 2025-12-02 | 赛欧生物医药股份有限公司 | 经修饰的脂质组合物及其用途 |
| WO2024167885A1 (en) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory compositions and related methods |
| EP4680750A1 (en) | 2023-03-15 | 2026-01-21 | Flagship Pioneering Innovations VI, LLC | Compositions comprising polyribonucleotides and uses thereof |
| CN121358494A (zh) | 2023-03-15 | 2026-01-16 | 旗舰创业创新第六有限责任公司 | 免疫原性组合物及其用途 |
| WO2024220752A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Rna therapeutic compositions |
| WO2024220625A1 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids |
| WO2024220712A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Vaccine compositions |
| WO2024226621A1 (en) * | 2023-04-25 | 2024-10-31 | Ginkgo Bioworks, Inc. | Novel internal ribosome entry site (ires) and intron sequences |
| EP4705481A2 (en) | 2023-05-05 | 2026-03-11 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| WO2024254546A2 (en) * | 2023-06-08 | 2024-12-12 | Cornell University | Virus-like particles comprising circular mrna expression systems and methods of use thereof |
| WO2025006684A1 (en) | 2023-06-28 | 2025-01-02 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
| WO2025034727A1 (en) * | 2023-08-07 | 2025-02-13 | Yale University | Translational modulating elements for mrna molecules capped with 5'-cap analogs, mrna molecules including the same, and methods using the same |
| WO2025042786A1 (en) | 2023-08-18 | 2025-02-27 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| WO2025072615A1 (en) | 2023-09-29 | 2025-04-03 | Orbital Therapeutics, Inc. | Improved methods of making rna by splinted ligation and compositions thereof |
| WO2025077734A1 (en) * | 2023-10-09 | 2025-04-17 | Shanghai Circode Biomed Co., Ltd. | Constructs and methods for preparing circular rnas and uses thereof |
| WO2025101501A1 (en) | 2023-11-07 | 2025-05-15 | Orna Therapeutics, Inc. | Circular rna compositions |
| WO2025106915A1 (en) | 2023-11-17 | 2025-05-22 | Sail Biomedicines, Inc. | Circular polyribonucleotides encoding glucagon-like peptide 1 (glp-1) and uses thereof |
| WO2025106930A1 (en) | 2023-11-17 | 2025-05-22 | Sail Biomedicines, Inc. | Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof |
| TW202545974A (zh) | 2024-01-26 | 2025-12-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 免疫受體抑制蛋白及相關方法 |
| WO2025179198A1 (en) | 2024-02-23 | 2025-08-28 | Sail Biomedicines, Inc. | Circular polyribonucleotides and unmodified linear rnas with reduced immunogenicity |
| US20250353881A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025245111A1 (en) | 2024-05-22 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor targeting proteins and related methods |
| WO2025250751A1 (en) | 2024-05-31 | 2025-12-04 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| WO2026006593A1 (en) | 2024-06-28 | 2026-01-02 | Orna Therapeutics, Inc. | Synthetic internal ribosome entry sites |
| WO2026060273A1 (en) * | 2024-09-13 | 2026-03-19 | Shape Therapeutics Inc. | 5' untranslated regions (utrs) for enhanced payload expression |
| WO2026072709A1 (en) | 2024-09-25 | 2026-04-02 | Orna Therapeutics, Inc. | Chimeric antigen receptors targeting bcma |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766903A (en) * | 1995-08-23 | 1998-06-16 | University Technology Corporation | Circular RNA and uses thereof |
| US6869779B1 (en) * | 1998-08-27 | 2005-03-22 | Fuso Pharmaceutical Industries, Ltd. | Nucleic acid sequence for potentiating the expression of useful gene and method therefor |
| DE10143238A1 (de) * | 2001-09-04 | 2003-03-20 | Icon Genetics Ag | Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente |
| DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
| US20050118625A1 (en) * | 2003-10-02 | 2005-06-02 | Mounts William M. | Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases |
| WO2010084371A1 (en) | 2009-01-26 | 2010-07-29 | Mitoprod | Novel circular interfering rna molecules |
| EP2531515B1 (en) * | 2010-01-22 | 2015-10-21 | Gen-Probe Incorporated | Probes for detecting the presence of trochomonas vaginalis in a sample |
| DK2925866T3 (en) | 2012-11-30 | 2018-10-29 | Univ Aarhus | CIRCULAR RNA FOR INHIBITING MICRO-RNA |
| EP2996697B1 (en) * | 2013-05-15 | 2019-06-26 | Robert Kruse | Intracellular translation of circular rna |
| US10407683B2 (en) | 2014-07-16 | 2019-09-10 | Modernatx, Inc. | Circular polynucleotides |
| EP3374504B1 (en) * | 2015-11-09 | 2025-03-19 | CureVac SE | Optimized nucleic acid molecules |
| WO2017222911A1 (en) | 2016-06-20 | 2017-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Circular rnas and their use in immunomodulation |
| JP7385282B2 (ja) * | 2017-11-07 | 2023-11-22 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 環状ｒｎａ分子のための方法及び組成物 |
| CN112399860B (zh) * | 2018-06-06 | 2024-08-16 | 麻省理工学院 | 用于在真核细胞中翻译的环状rna |
| WO2020023655A1 (en) * | 2018-07-24 | 2020-01-30 | Flagship Pioneering, Inc. | Compositions comprising circular polyribonucleotides and uses thereof |
| AU2019310448A1 (en) * | 2018-07-24 | 2021-03-11 | Mayo Foundation For Medical Education And Research | Circularized engineered rna and methods |
| US20220362295A1 (en) | 2019-04-22 | 2022-11-17 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
-
2021
- 2021-06-25 KR KR1020237001270A patent/KR20230028375A/ko active Pending
- 2021-06-25 CA CA3180224A patent/CA3180224A1/en active Pending
- 2021-06-25 WO PCT/US2021/039127 patent/WO2021263124A2/en not_active Ceased
- 2021-06-25 EP EP21829176.3A patent/EP4171631A4/en active Pending
- 2021-06-25 AU AU2021297340A patent/AU2021297340A1/en active Pending
- 2021-06-25 JP JP2022580043A patent/JP2023532663A/ja active Pending
- 2021-06-25 CN CN202180052292.1A patent/CN116323945A/zh active Pending
-
2022
- 2022-03-16 US US17/696,606 patent/US11560567B2/en active Active
- 2022-10-03 US US17/937,617 patent/US11685924B2/en active Active
-
2023
- 2023-06-23 US US18/340,582 patent/US20230407317A1/en active Pending
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