JP2003503355A5 - - Google Patents
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- Publication number
- JP2003503355A5 JP2003503355A5 JP2001505929A JP2001505929A JP2003503355A5 JP 2003503355 A5 JP2003503355 A5 JP 2003503355A5 JP 2001505929 A JP2001505929 A JP 2001505929A JP 2001505929 A JP2001505929 A JP 2001505929A JP 2003503355 A5 JP2003503355 A5 JP 2003503355A5
- Authority
- JP
- Japan
- Prior art keywords
- lpl
- seq
- protein
- therapeutic
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004707 nucleic acids Proteins 0.000 description 17
- 102000039446 nucleic acids Human genes 0.000 description 17
- 150000007523 nucleic acids Chemical class 0.000 description 17
- 108090000623 proteins and genes Proteins 0.000 description 17
- 102000004169 proteins and genes Human genes 0.000 description 17
- 239000003814 drug Substances 0.000 description 16
- 239000013598 vector Substances 0.000 description 16
- 229940124597 therapeutic agent Drugs 0.000 description 15
- 230000001225 therapeutic effect Effects 0.000 description 14
- 238000001415 gene therapy Methods 0.000 description 12
- 239000002773 nucleotide Substances 0.000 description 8
- 125000003729 nucleotide group Chemical group 0.000 description 8
- 108091026890 Coding region Proteins 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 239000013603 viral vector Substances 0.000 description 5
- 241000702421 Dependoparvovirus Species 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 201000011110 familial lipoprotein lipase deficiency Diseases 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 201000000054 Coronary Restenosis Diseases 0.000 description 1
- 206010056489 Coronary artery restenosis Diseases 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021024 Hypolipidaemia Diseases 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- 208000029498 hypoalphalipoproteinemia Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/898,684 US20110201673A1 (en) | 1999-06-24 | 2010-10-05 | Lpl variant therapeutics |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99202048 | 1999-06-24 | ||
| EP99202048.7 | 1999-06-24 | ||
| PCT/CA2000/000762 WO2001000220A2 (en) | 1999-06-24 | 2000-06-23 | Lipoprotein lipase (lpl) variant therapeutics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003503355A JP2003503355A (ja) | 2003-01-28 |
| JP2003503355A5 true JP2003503355A5 (https=) | 2007-08-09 |
| JP5095894B2 JP5095894B2 (ja) | 2012-12-12 |
Family
ID=8240356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001505929A Expired - Fee Related JP5095894B2 (ja) | 1999-06-24 | 2000-06-23 | リポタンパク質リパーゼ（ｌｐｌ）変異体治療薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110201673A1 (https=) |
| EP (1) | EP1200117B1 (https=) |
| JP (1) | JP5095894B2 (https=) |
| AT (1) | ATE404217T1 (https=) |
| AU (1) | AU5799200A (https=) |
| CA (1) | CA2370081C (https=) |
| CY (1) | CY1108511T1 (https=) |
| DE (1) | DE60039880D1 (https=) |
| DK (1) | DK1200117T3 (https=) |
| ES (1) | ES2311464T3 (https=) |
| PT (1) | PT1200117E (https=) |
| WO (1) | WO2001000220A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE437657T1 (de) * | 2004-03-02 | 2009-08-15 | Cellectar Inc | Phospholipid-analoga für die behandlung von krebs |
| PT1761273E (pt) * | 2004-06-21 | 2008-10-28 | Amsterdam Molecular Therapeutics Bv | Tratamento da esteatohepatite não alcoólica (nash) |
| EP2311966A3 (en) | 2005-10-20 | 2012-09-05 | Amsterdam Molecular Therapeutics (AMT) B.V. | Improved AAV vectors produced in insect cells |
| CN103849629B (zh) | 2006-06-21 | 2017-06-09 | 尤尼克尔Ip股份有限公司 | 具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体 |
| DK2173888T3 (en) | 2007-07-26 | 2016-11-28 | Uniqure Ip Bv | Baculovirus vectors comprising repeating coding sequences WITH differential preferred codons |
| WO2009030254A1 (en) * | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| EP2432497A1 (en) * | 2009-05-18 | 2012-03-28 | Amsterdam Molecular Therapeutics (AMT) IP B.V. | Use of lipoprotein lipase (lpl) in therapy |
| JP6092624B2 (ja) | 2009-06-12 | 2017-03-08 | セレクター，インコーポレイティド | 癌の治療並びに癌幹細胞の造影および検出のためのエーテルおよびアルキルリン脂質化合物 |
| EP2545165B1 (en) | 2010-03-11 | 2020-07-29 | uniQure IP B.V. | Mutated rep encoding sequences for use in aav production |
| WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
| JP6188728B2 (ja) | 2012-02-07 | 2017-08-30 | グローバル・バイオ・セラピューティクス・インコーポレイテッドＧｌｏｂａｌ Ｂｉｏ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 核酸送達の区画化方法ならびにその組成物および使用 |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| CA2942289C (en) | 2014-03-10 | 2024-05-21 | Uniqure Ip B.V. | Further improved aav vectors produced in insect cells |
| MA41035A (fr) * | 2014-08-19 | 2017-08-15 | Shire Human Genetic Therapies | Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë |
| US12123030B2 (en) | 2016-05-18 | 2024-10-22 | Modernatx, Inc. | Polynucleotides encoding lipoprotein lipase for the treatment of hyperlipidemia |
| WO2018109207A1 (en) | 2016-12-16 | 2018-06-21 | Uniqure Ip B.V. | Immunoadsorption |
| JP7764129B2 (ja) | 2017-07-10 | 2025-11-05 | ユニキュアー アイピー ビー．ブイ． | ヒトにおけるａａｖ遺伝子療法のための手段及び方法 |
| EP3655538A1 (en) | 2017-07-20 | 2020-05-27 | uniQure IP B.V. | Improved aav capsid production in insect cells |
| WO2019129859A1 (en) | 2017-12-29 | 2019-07-04 | Uniqure Ip B.V. | Modified viral vectors and methods of making and using the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2188675A1 (en) * | 1994-04-11 | 1995-10-19 | Savio L. C. Woo | Compositions and methods for gene therapy to treat disease |
| US5658729A (en) * | 1994-10-11 | 1997-08-19 | The University Of British Columbia | Method, reagent and kit for evaluating susceptibility to premature atherosclerosis |
-
2000
- 2000-06-23 AU AU57992/00A patent/AU5799200A/en not_active Abandoned
- 2000-06-23 CA CA2370081A patent/CA2370081C/en not_active Expired - Fee Related
- 2000-06-23 AT AT00943499T patent/ATE404217T1/de active
- 2000-06-23 WO PCT/CA2000/000762 patent/WO2001000220A2/en not_active Ceased
- 2000-06-23 DE DE60039880T patent/DE60039880D1/de not_active Expired - Lifetime
- 2000-06-23 EP EP20000943499 patent/EP1200117B1/en not_active Expired - Lifetime
- 2000-06-23 DK DK00943499T patent/DK1200117T3/da active
- 2000-06-23 PT PT00943499T patent/PT1200117E/pt unknown
- 2000-06-23 ES ES00943499T patent/ES2311464T3/es not_active Expired - Lifetime
- 2000-06-23 JP JP2001505929A patent/JP5095894B2/ja not_active Expired - Fee Related
-
2008
- 2008-11-13 CY CY20081101305T patent/CY1108511T1/el unknown
-
2010
- 2010-10-05 US US12/898,684 patent/US20110201673A1/en not_active Abandoned
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