DE60039880D1 - Therapie mit lipoproteinlipase (lpl) variant - Google Patents
Therapie mit lipoproteinlipase (lpl) variantInfo
- Publication number
- DE60039880D1 DE60039880D1 DE60039880T DE60039880T DE60039880D1 DE 60039880 D1 DE60039880 D1 DE 60039880D1 DE 60039880 T DE60039880 T DE 60039880T DE 60039880 T DE60039880 T DE 60039880T DE 60039880 D1 DE60039880 D1 DE 60039880D1
- Authority
- DE
- Germany
- Prior art keywords
- lpl
- lipoproteinlipase
- variant
- therapie mit
- therapie
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01034—Lipoprotein lipase (3.1.1.34)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99202048 | 1999-06-24 | ||
PCT/CA2000/000762 WO2001000220A2 (en) | 1999-06-24 | 2000-06-23 | Lipoprotein lipase (lpl) variant therapeutics |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60039880D1 true DE60039880D1 (en) | 2008-09-25 |
Family
ID=8240356
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60039880T Expired - Lifetime DE60039880D1 (en) | 1999-06-24 | 2000-06-23 | Therapie mit lipoproteinlipase (lpl) variant |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110201673A1 (de) |
EP (1) | EP1200117B1 (de) |
JP (1) | JP5095894B2 (de) |
AT (1) | ATE404217T1 (de) |
AU (1) | AU5799200A (de) |
CA (1) | CA2370081C (de) |
CY (1) | CY1108511T1 (de) |
DE (1) | DE60039880D1 (de) |
DK (1) | DK1200117T3 (de) |
ES (1) | ES2311464T3 (de) |
PT (1) | PT1200117E (de) |
WO (1) | WO2001000220A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007528374A (ja) * | 2004-03-02 | 2007-10-11 | セレクター,リミティド ライアビリティ カンパニー | Diapeutic(登録商標)剤としてのリン脂質類似体、及びその方法 |
CN1972709A (zh) * | 2004-06-21 | 2007-05-30 | 阿姆斯特丹大学医学院 | 非酒精性脂肪性肝炎的治疗方法 |
DK1945779T3 (da) | 2005-10-20 | 2013-06-03 | Uniqure Ip Bv | Forbedrede AAV vektorer frembragt i insektceller |
KR101589259B1 (ko) | 2006-06-21 | 2016-02-01 | 유니큐어 아이피 비.브이. | 곤충세포 내 aav의 생산에 유용한 aav-rep78의 번역을 위한 변형된 개시 코돈을 갖는 벡터 |
SI2173888T1 (sl) | 2007-07-26 | 2017-01-31 | Uniqure Ip B.V. | Bakulovirusni vektorji, ki vsebujejo ponavljajoča kodirna zaporedja z različnimi kodonskimi preferencami |
WO2009030254A1 (en) * | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
WO2010134806A1 (en) * | 2009-05-18 | 2010-11-25 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Use of lipoprotein lipase (lpl) in therapy |
SI3708192T1 (sl) | 2009-06-12 | 2023-12-29 | Cellectar, Inc. | Eter fosfolipidne spojine za zdravljenje raka in slikanje in detekcijo rakavih izvornih celic |
EP3792348A3 (de) | 2010-03-11 | 2021-06-23 | uniQure IP B.V. | Mutierte rep codierende sequenzen zur verwendung in der aav-produktion |
WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
CN110917362A (zh) | 2012-02-07 | 2020-03-27 | 全球生物疗法有限公司 | 核酸输送的区室化方法及其组合物和应用 |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
WO2015051214A1 (en) | 2013-10-03 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
BR112016020783A2 (pt) | 2014-03-10 | 2017-10-03 | Uniqure Ip Bv | Vetores de aav adicionalmente melhorados produzidos em células de inseto |
MA41035A (fr) * | 2014-08-19 | 2017-08-15 | Shire Human Genetic Therapies | Lipoprotéine lipase pour le traitement d'affections liées à une hypertriglycéridémie, y compris la pancréatite aiguë |
US20190390181A1 (en) * | 2016-05-18 | 2019-12-26 | Modernatx, Inc. | Polynucleotides Encoding Lipoprotein Lipase for the Treatment of Hyperlipidemia |
US10286087B2 (en) | 2016-12-16 | 2019-05-14 | Uniqure Ip B.V. | Immunoadsorption |
KR20200041310A (ko) | 2017-07-10 | 2020-04-21 | 유니큐어 아이피 비.브이. | 인간에서의 aav 유전자 요법을 위한 수단 및 방법 |
WO2019016349A1 (en) | 2017-07-20 | 2019-01-24 | Uniqure Ip B.V. | PRODUCTION OF ENHANCED VAA CAPSIDS IN INSECT CELLS |
WO2019129859A1 (en) | 2017-12-29 | 2019-07-04 | Uniqure Ip B.V. | Modified viral vectors and methods of making and using the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0755268A1 (de) * | 1994-04-11 | 1997-01-29 | Baylor College Of Medicine | Zusammensetzungen und verfahren zur behandlung von erkrankungen durch gentherapie |
US5658729A (en) * | 1994-10-11 | 1997-08-19 | The University Of British Columbia | Method, reagent and kit for evaluating susceptibility to premature atherosclerosis |
-
2000
- 2000-06-23 PT PT00943499T patent/PT1200117E/pt unknown
- 2000-06-23 WO PCT/CA2000/000762 patent/WO2001000220A2/en active IP Right Grant
- 2000-06-23 ES ES00943499T patent/ES2311464T3/es not_active Expired - Lifetime
- 2000-06-23 AU AU57992/00A patent/AU5799200A/en not_active Abandoned
- 2000-06-23 CA CA2370081A patent/CA2370081C/en not_active Expired - Fee Related
- 2000-06-23 DK DK00943499T patent/DK1200117T3/da active
- 2000-06-23 DE DE60039880T patent/DE60039880D1/de not_active Expired - Lifetime
- 2000-06-23 EP EP20000943499 patent/EP1200117B1/de not_active Expired - Lifetime
- 2000-06-23 JP JP2001505929A patent/JP5095894B2/ja not_active Expired - Fee Related
- 2000-06-23 AT AT00943499T patent/ATE404217T1/de active
-
2008
- 2008-11-13 CY CY20081101305T patent/CY1108511T1/el unknown
-
2010
- 2010-10-05 US US12/898,684 patent/US20110201673A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1200117A2 (de) | 2002-05-02 |
CA2370081A1 (en) | 2001-01-04 |
WO2001000220A3 (en) | 2001-07-12 |
CY1108511T1 (el) | 2014-04-09 |
JP2003503355A (ja) | 2003-01-28 |
DK1200117T3 (da) | 2008-11-17 |
CA2370081C (en) | 2014-06-03 |
PT1200117E (pt) | 2008-11-26 |
US20110201673A1 (en) | 2011-08-18 |
WO2001000220A2 (en) | 2001-01-04 |
AU5799200A (en) | 2001-01-31 |
ES2311464T3 (es) | 2009-02-16 |
JP5095894B2 (ja) | 2012-12-12 |
ATE404217T1 (de) | 2008-08-15 |
EP1200117B1 (de) | 2008-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |