JP2021521842A5 - - Google Patents
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- Publication number
- JP2021521842A5 JP2021521842A5 JP2020560228A JP2020560228A JP2021521842A5 JP 2021521842 A5 JP2021521842 A5 JP 2021521842A5 JP 2020560228 A JP2020560228 A JP 2020560228A JP 2020560228 A JP2020560228 A JP 2020560228A JP 2021521842 A5 JP2021521842 A5 JP 2021521842A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- sequence number
- item
- nucleic acid
- polynucleotide
- Prior art date
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023130016A JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
| JP2025084732A JP2025122095A (ja) | 2018-04-27 | 2025-05-21 | ミオシン１５プロモーター及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663679P | 2018-04-27 | 2018-04-27 | |
| US62/663,679 | 2018-04-27 | ||
| PCT/US2019/029366 WO2019210181A1 (en) | 2018-04-27 | 2019-04-26 | Myosin 15 promoters and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023130016A Division JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021521842A JP2021521842A (ja) | 2021-08-30 |
| JPWO2019210181A5 JPWO2019210181A5 (https=) | 2022-05-09 |
| JP2021521842A5 true JP2021521842A5 (https=) | 2022-05-09 |
| JP7331011B2 JP7331011B2 (ja) | 2023-08-22 |
Family
ID=68294246
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560228A Active JP7331011B2 (ja) | 2018-04-27 | 2019-04-26 | ミオシン１５プロモーター及びその使用 |
| JP2023130016A Active JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
| JP2025084732A Pending JP2025122095A (ja) | 2018-04-27 | 2025-05-21 | ミオシン１５プロモーター及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023130016A Active JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
| JP2025084732A Pending JP2025122095A (ja) | 2018-04-27 | 2025-05-21 | ミオシン１５プロモーター及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12233136B2 (https=) |
| JP (3) | JP7331011B2 (https=) |
| CN (3) | CN119410636A (https=) |
| AU (1) | AU2019257782B2 (https=) |
| CA (1) | CA3098198A1 (https=) |
| WO (1) | WO2019210181A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| WO2020123713A1 (en) * | 2018-12-11 | 2020-06-18 | Decibel Therapeutics, Inc. | Compositions and methods for the delivery of therapeutic agents across the round window membrane |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| AU2020218547A1 (en) | 2019-02-08 | 2021-08-26 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| CA3159549A1 (en) | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| EP4054653A4 (en) * | 2019-11-04 | 2023-11-29 | Decibel Therapeutics, Inc. | PROMOTERS OF COCHLEAR EXTERNAL HAIR CELLS AND THEIR USES |
| EP4055175A4 (en) | 2019-11-04 | 2023-11-29 | Decibel Therapeutics, Inc. | Cochlear inner hair cell promoters and uses thereof |
| JP7807380B2 (ja) | 2020-02-21 | 2026-01-27 | アコーオス インコーポレイテッド | ヒト対象において非加齢関連聴力障害を処置するための組成物および方法 |
| WO2021222682A1 (en) * | 2020-04-30 | 2021-11-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Application of aav44.9 vector in gene therapy for the inner ear |
| US20250114480A1 (en) * | 2022-01-25 | 2025-04-10 | Bridgebio Gene Therapy Research, Inc. | Gene therapy for genetic hearing loss |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| US6436392B1 (en) | 1998-05-20 | 2002-08-20 | University Of Iowa Research Foundation | Adeno-associated virus vectors |
| WO1999064627A2 (en) * | 1998-06-06 | 1999-12-16 | Genostic Pharma Limited | Probes used for genetic profiling |
| EP1224313A1 (en) | 1999-10-07 | 2002-07-24 | University of Iowa Research Foundation | Adeno-associated viruses and uses thereof |
| WO2001029243A1 (en) | 1999-10-15 | 2001-04-26 | Dalhousie University | Method and vector for producing and transferring trans-spliced peptides |
| US20040072154A1 (en) | 2000-12-22 | 2004-04-15 | Morris David W. | Novel compositions and methods for cancer |
| JP2003088388A (ja) | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長ｃＤＮＡ |
| US20070161031A1 (en) | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
| US8298818B2 (en) | 2006-04-28 | 2012-10-30 | University Of Florida Research Foundation, Inc. | Self-complementary adeno-associated virus having a truncated CMV-chicken β-actin promoter |
| JP5575486B2 (ja) | 2007-01-18 | 2014-08-20 | ユニヴァーシティ オブ ミズーリー−コロンビア | 筋鞘にｎＮＯＳを回復させる合成ミニ／ミクロジストロフィン遺伝子 |
| FR2919305B1 (fr) | 2007-07-26 | 2009-09-18 | Genethon Ass Loi De 1901 | Vecteurs viraux adeno-associes pour l'expression de la dysferline. |
| EP2732819B1 (en) * | 2008-02-07 | 2019-10-16 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
| US8236557B2 (en) | 2008-05-28 | 2012-08-07 | University Of Missouri-Columbia | Hybrid-AAV vectors to deliver large gene expression cassette |
| US8962314B2 (en) | 2008-11-26 | 2015-02-24 | The Regents Of The University Of California | Lateral ventricle cell compositions and use for treating neural degenerative diseases |
| HRP20190144T1 (hr) | 2010-04-23 | 2019-03-22 | University Of Florida Research Foundation, Inc. | Pripravci raav-gvanilat ciklaze i postupci za liječenje leberove urođene amauroze-1 (lca1) |
| KR20140047141A (ko) * | 2011-08-03 | 2014-04-21 | 쿠아크 파마수티칼스 인코퍼레이티드 | 청력 및 균형 장애를 치료하기 위한 이중-가닥 올리고뉴클레오티드 화합물들 |
| WO2013075008A1 (en) | 2011-11-16 | 2013-05-23 | University Of Florida Research Foundation Inc. | Aav dual vector systems for gene therapy |
| EP2802657B1 (en) * | 2012-01-12 | 2018-05-02 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
| AU2013249202B2 (en) | 2012-04-18 | 2018-08-09 | The Children's Hospital Of Philadelphia | Composition and methods for highly efficient gene transfer using AAV capsid variants |
| CA2884309A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity |
| CA2909733C (en) | 2013-04-18 | 2023-10-17 | Fondazione Telethon | Effective delivery of large genes by dual aav vectors |
| KR102234672B1 (ko) | 2013-05-21 | 2021-04-06 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 캡시드-변형된 raav3 벡터 조성물, 및 인간 간암의 유전자 요법에서의 용도 |
| US10751385B2 (en) | 2015-02-20 | 2020-08-25 | Institut Pasteur | Prevention and/or treatment of hearing loss or impairment |
| RS63416B1 (sr) | 2015-03-03 | 2022-08-31 | Fond Telethon | Sistem višestrukih vektora i njegove primene |
| SG11201804814YA (en) * | 2015-12-11 | 2018-07-30 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| WO2017108931A1 (en) | 2015-12-22 | 2017-06-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Improved hybrid dual recombinant aav vector systems for gene therapy |
| JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| WO2018145111A1 (en) | 2017-02-06 | 2018-08-09 | Children's Medical Center Corporation | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| AU2018261769B2 (en) | 2017-05-05 | 2024-03-14 | The Regents Of The University Of California | Compositions and methods for expressing Otoferlin |
| DE102018103924A1 (de) | 2018-02-21 | 2019-08-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Gentherapeutische Behandlung von Schwerhörigkeit |
| IL325122A (en) | 2018-02-22 | 2026-02-01 | Akouos Inc | Compositions and methods for treating non-age-related hearing impairment in humans |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| US12188041B2 (en) | 2018-11-01 | 2025-01-07 | University Of Florida Research Foundation, Incorporated | Codon optimized otoferlin AAV dual vector gene therapy |
| CN118497276A (zh) | 2018-11-07 | 2024-08-16 | 阿库斯股份有限公司 | 腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途 |
| JP2022522995A (ja) | 2019-01-18 | 2022-04-21 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖ粒子を生成するための方法及びシステム |
| WO2020148458A1 (en) | 2019-01-18 | 2020-07-23 | Institut Pasteur | Aav-mediated gene therapy restoring the otoferlin gene |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| AU2020218547A1 (en) | 2019-02-08 | 2021-08-26 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| CA3159549A1 (en) | 2019-10-30 | 2021-05-06 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| CN117295529A (zh) | 2021-02-19 | 2023-12-26 | 分贝治疗公司 | 使用耳畸蛋白双载体系统治疗感觉神经性听力损失的方法 |
-
2019
- 2019-04-26 CN CN202411557776.3A patent/CN119410636A/zh active Pending
- 2019-04-26 CA CA3098198A patent/CA3098198A1/en active Pending
- 2019-04-26 WO PCT/US2019/029366 patent/WO2019210181A1/en not_active Ceased
- 2019-04-26 US US17/050,741 patent/US12233136B2/en active Active
- 2019-04-26 JP JP2020560228A patent/JP7331011B2/ja active Active
- 2019-04-26 CN CN201980042739.XA patent/CN112703016B/zh active Active
- 2019-04-26 AU AU2019257782A patent/AU2019257782B2/en active Active
- 2019-04-26 CN CN202411557780.XA patent/CN119410637A/zh active Pending
-
2023
- 2023-08-09 JP JP2023130016A patent/JP7686709B2/ja active Active
-
2025
- 2025-01-17 US US19/027,519 patent/US20250319205A1/en active Pending
- 2025-05-21 JP JP2025084732A patent/JP2025122095A/ja active Pending
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