JP2021521842A5 - - Google Patents
Info
- Publication number
- JP2021521842A5 JP2021521842A5 JP2020560228A JP2020560228A JP2021521842A5 JP 2021521842 A5 JP2021521842 A5 JP 2021521842A5 JP 2020560228 A JP2020560228 A JP 2020560228A JP 2020560228 A JP2020560228 A JP 2020560228A JP 2021521842 A5 JP2021521842 A5 JP 2021521842A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- sequence number
- item
- nucleic acid
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023130016A JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
| JP2025084732A JP2025122095A (ja) | 2018-04-27 | 2025-05-21 | ミオシン１５プロモーター及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663679P | 2018-04-27 | 2018-04-27 | |
| US62/663,679 | 2018-04-27 | ||
| PCT/US2019/029366 WO2019210181A1 (en) | 2018-04-27 | 2019-04-26 | Myosin 15 promoters and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023130016A Division JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521842A JP2021521842A (ja) | 2021-08-30 |
| JP2021521842A5 true JP2021521842A5 (https=) | 2022-05-09 |
| JP7331011B2 JP7331011B2 (ja) | 2023-08-22 |
Family
ID=68294246
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560228A Active JP7331011B2 (ja) | 2018-04-27 | 2019-04-26 | ミオシン１５プロモーター及びその使用 |
| JP2023130016A Active JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
| JP2025084732A Pending JP2025122095A (ja) | 2018-04-27 | 2025-05-21 | ミオシン１５プロモーター及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023130016A Active JP7686709B2 (ja) | 2018-04-27 | 2023-08-09 | ミオシン１５プロモーター及びその使用 |
| JP2025084732A Pending JP2025122095A (ja) | 2018-04-27 | 2025-05-21 | ミオシン１５プロモーター及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12233136B2 (https=) |
| JP (3) | JP7331011B2 (https=) |
| CN (3) | CN112703016B (https=) |
| AU (1) | AU2019257782B2 (https=) |
| CA (1) | CA3098198A1 (https=) |
| WO (1) | WO2019210181A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING PERSONAL HEARING LOSS IN A PERSON |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| US20220054640A1 (en) * | 2018-12-11 | 2022-02-24 | Decibel Therapeutics, Inc. | Compositions and methods for the delivery of therapeutic agents across the round window membrane |
| CA3129422A1 (en) | 2019-02-08 | 2020-08-13 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| KR20220130093A (ko) * | 2019-10-30 | 2022-09-26 | 데시벨 테라퓨틱스, 인크. | 오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법 |
| WO2021091938A1 (en) * | 2019-11-04 | 2021-05-14 | Decibel Therapeutics, Inc. | Cochlear outer hair cell promoters and uses thereof |
| EP4055175A4 (en) | 2019-11-04 | 2023-11-29 | Decibel Therapeutics, Inc. | Cochlear inner hair cell promoters and uses thereof |
| KR20220157944A (ko) | 2020-02-21 | 2022-11-29 | 아카우오스, 인크. | 인간 대상체에서 비-연령-연관 청각 장애를 치료하기 위한 조성물 및 방법 |
| WO2021222682A1 (en) * | 2020-04-30 | 2021-11-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Application of aav44.9 vector in gene therapy for the inner ear |
| WO2023147383A1 (en) * | 2022-01-25 | 2023-08-03 | Bridgebio Services Inc. | Gene therapy for genetic hearing loss |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| US6436392B1 (en) | 1998-05-20 | 2002-08-20 | University Of Iowa Research Foundation | Adeno-associated virus vectors |
| WO1999064627A2 (en) * | 1998-06-06 | 1999-12-16 | Genostic Pharma Limited | Probes used for genetic profiling |
| EP1224313A1 (en) | 1999-10-07 | 2002-07-24 | University of Iowa Research Foundation | Adeno-associated viruses and uses thereof |
| AU7895700A (en) | 1999-10-15 | 2001-04-30 | Dalhousie University | Method and vector for producing and transferring trans-spliced peptides |
| US20040072154A1 (en) | 2000-12-22 | 2004-04-15 | Morris David W. | Novel compositions and methods for cancer |
| JP2003088388A (ja) | 2001-09-14 | 2003-03-25 | Herikkusu Kenkyusho:Kk | 新規な全長ｃＤＮＡ |
| US20070161031A1 (en) | 2005-12-16 | 2007-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Functional arrays for high throughput characterization of gene expression regulatory elements |
| WO2007127428A2 (en) | 2006-04-28 | 2007-11-08 | University Of Florida Research Foundation, Inc. | Double-stranded/self-complementary vectors with a truncated cba promoter and methods of gene delivery |
| CN101711164B (zh) | 2007-01-18 | 2014-06-04 | 密苏里-哥伦比亚大学 | 可修复肌纤维膜中的神经元型一氧化氮合酶的合成小/微-抗肌萎缩蛋白基因 |
| FR2919305B1 (fr) | 2007-07-26 | 2009-09-18 | Genethon Ass Loi De 1901 | Vecteurs viraux adeno-associes pour l'expression de la dysferline. |
| US8188131B2 (en) | 2008-02-07 | 2012-05-29 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh1 expression |
| US8236557B2 (en) | 2008-05-28 | 2012-08-07 | University Of Missouri-Columbia | Hybrid-AAV vectors to deliver large gene expression cassette |
| WO2010062905A2 (en) | 2008-11-26 | 2010-06-03 | The Regents Of The University Of California | Lateral ventricle cell compositions and use for treating neural degenerative diseases |
| SG10201800541SA (en) | 2010-04-23 | 2018-03-28 | Univ Florida | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
| BR112014002638A2 (pt) * | 2011-08-03 | 2017-02-21 | Quark Pharmaceuticals Inc | compostos de oligonucleo tídeo de fita dupla para tratar desordens de audição e equilíbrio |
| WO2013075008A1 (en) | 2011-11-16 | 2013-05-23 | University Of Florida Research Foundation Inc. | Aav dual vector systems for gene therapy |
| BR112014016937A2 (pt) * | 2012-01-12 | 2017-06-13 | Quark Pharmaceuticals Inc | terapia de combinação para o tratamento de desordens de audição e do equilíbrio |
| NZ701693A (en) | 2012-04-18 | 2017-02-24 | The Children’S Hospital Of Philadelphia | Composition and methods for highly efficient gene transfer using aav capsid variants |
| US20150209406A1 (en) | 2012-09-07 | 2015-07-30 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells |
| AU2014255665B2 (en) | 2013-04-18 | 2018-08-02 | Fondazione Telethon | Effective delivery of large genes by dual AAV vectors |
| EP3492597A3 (en) | 2013-05-21 | 2019-08-28 | University of Florida Research Foundation, Inc. | Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer |
| EP3258955A1 (en) * | 2015-02-20 | 2017-12-27 | Institut Pasteur | Prevention and/or treatment of hearing loss or impairment |
| SI3265571T1 (sl) | 2015-03-03 | 2022-10-28 | Fondazione Telethon | Več vektorski sistem in njegove uporabe |
| SG10201913266UA (en) | 2015-12-11 | 2020-02-27 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| JP7007273B2 (ja) | 2015-12-22 | 2022-01-24 | アンセルム（アンスティチュート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル） | 遺伝子治療用の改良された複合型二重組換えａａｖベクターシステム |
| EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING PERSONAL HEARING LOSS IN A PERSON |
| WO2018145111A1 (en) | 2017-02-06 | 2018-08-09 | Children's Medical Center Corporation | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| KR102606810B1 (ko) | 2017-05-05 | 2023-11-27 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 오토펄린을 발현시키기 위한 조성물 및 방법 |
| DE102018103924A1 (de) | 2018-02-21 | 2019-08-22 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Gentherapeutische Behandlung von Schwerhörigkeit |
| IL325122A (en) | 2018-02-22 | 2026-02-01 | Akouos Inc | Compositions and methods for treating non-age-related hearing impairment in humans |
| US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| WO2020093018A1 (en) | 2018-11-01 | 2020-05-07 | University Of Florida Research Foundation, Incorporated | A codon optimized otoferlin aav dual vector gene therapy |
| EP4063510A1 (en) | 2018-11-07 | 2022-09-28 | Akouos, Inc. | Use of adeno-associated viral vectors to correct gene defects/ express proteins in hair cells and supporting cells in the inner ear |
| SG11202107645RA (en) | 2019-01-18 | 2021-08-30 | Voyager Therapeutics Inc | Methods and systems for producing aav particles |
| EP4295913A3 (en) | 2019-01-18 | 2024-03-06 | Institut Pasteur | Aav-mediated gene therapy restoring the otoferlin gene |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| CA3129422A1 (en) | 2019-02-08 | 2020-08-13 | Decibel Therapeutics, Inc. | Myosin 15 promoters and uses thereof |
| KR20220130093A (ko) | 2019-10-30 | 2022-09-26 | 데시벨 테라퓨틱스, 인크. | 오토펄린 듀얼 벡터 시스템을 사용한 감각신경성 난청을 치료하기 위한 조성물 및 방법 |
| EP4294460A4 (en) | 2021-02-19 | 2025-06-25 | Decibel Therapeutics, Inc. | Methods for treating sensorineural hearing loss using otoferlin dual vector systems |
-
2019
- 2019-04-26 CN CN201980042739.XA patent/CN112703016B/zh active Active
- 2019-04-26 WO PCT/US2019/029366 patent/WO2019210181A1/en not_active Ceased
- 2019-04-26 CN CN202411557780.XA patent/CN119410637A/zh active Pending
- 2019-04-26 CA CA3098198A patent/CA3098198A1/en active Pending
- 2019-04-26 US US17/050,741 patent/US12233136B2/en active Active
- 2019-04-26 CN CN202411557776.3A patent/CN119410636A/zh active Pending
- 2019-04-26 AU AU2019257782A patent/AU2019257782B2/en active Active
- 2019-04-26 JP JP2020560228A patent/JP7331011B2/ja active Active
-
2023
- 2023-08-09 JP JP2023130016A patent/JP7686709B2/ja active Active
-
2025
- 2025-01-17 US US19/027,519 patent/US20250319205A1/en active Pending
- 2025-05-21 JP JP2025084732A patent/JP2025122095A/ja active Pending
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