JP2024508660A - 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬 - Google Patents

快感消失の治療に使用するための電位依存性カリウムチャネル開口薬 Download PDF

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JP2024508660A
JP2024508660A JP2023547490A JP2023547490A JP2024508660A JP 2024508660 A JP2024508660 A JP 2024508660A JP 2023547490 A JP2023547490 A JP 2023547490A JP 2023547490 A JP2023547490 A JP 2023547490A JP 2024508660 A JP2024508660 A JP 2024508660A
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compound
disorder
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anhedonia
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JP2024508660A5 (enExample
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サイモン ニール ピムストーン
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Xenon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Shovels (AREA)
  • Ignition Installations For Internal Combustion Engines (AREA)
JP2023547490A 2021-02-09 2022-02-09 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬 Pending JP2024508660A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163147742P 2021-02-09 2021-02-09
US63/147,742 2021-02-09
PCT/US2022/015854 WO2022173855A1 (en) 2021-02-09 2022-02-09 Voltage-gated potassium channel opener for use in treating anhedonia

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JP2024508660A true JP2024508660A (ja) 2024-02-28
JP2024508660A5 JP2024508660A5 (enExample) 2025-02-17

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JP2023547490A Pending JP2024508660A (ja) 2021-02-09 2022-02-09 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬

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US (3) US11957675B2 (enExample)
EP (1) EP4291189A1 (enExample)
JP (1) JP2024508660A (enExample)
KR (1) KR20240004241A (enExample)
CN (1) CN116847843A (enExample)
AU (1) AU2022220675A1 (enExample)
CA (1) CA3207191A1 (enExample)
CL (1) CL2023002321A1 (enExample)
GE (1) GEAP202416348A (enExample)
IL (1) IL304920A (enExample)
MA (1) MA61732A1 (enExample)
MX (1) MX2023009314A (enExample)
PE (1) PE20231815A1 (enExample)
TW (1) TW202245744A (enExample)
WO (1) WO2022173855A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3155812A1 (en) 2019-11-08 2021-05-14 Cynthia Louise HARDEN Methods of treating depressive disorders
GEAP202416349A (en) * 2021-02-09 2024-02-12 Xenon Pharmaceuticals Inc Conjoint therapy for treating seizure disorders
TW202245744A (zh) 2021-02-09 2022-12-01 加拿大商再諾製藥公司 治療失樂症之方法及用途
WO2025034745A1 (en) * 2023-08-07 2025-02-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 4-aminopiperidines as selective modulators of potassium channels
AU2024413931A1 (en) * 2023-12-28 2026-07-02 Alto Neuroscience, Inc. Compositions and methods for treating anhedonia

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501568A (ja) * 2006-08-23 2010-01-21 バレアント ファーマシューティカルズ インターナショナル カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体
JP2011513196A (ja) * 2007-08-01 2011-04-28 ハー・ルンドベック・アクチエゼルスカベット ドーパミン作動系が破壊された障害もしくは状態の症状を軽減するためまたはその障害もしくは状態を処置するためのｋｃｎｑカリウムチャネル開口薬の使用
JP2013518815A (ja) * 2010-02-01 2013-05-23 バレアント ファーマシューティカルズ インターナショナル カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体
WO2019217924A1 (en) * 2018-05-11 2019-11-14 Xenon Pharmaceuticals Inc. Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener

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US11957675B2 (en) 2024-04-16
EP4291189A1 (en) 2023-12-20
TW202245744A (zh) 2022-12-01
US12171759B1 (en) 2024-12-24
US20250186426A1 (en) 2025-06-12
IL304920A (en) 2023-10-01
GEAP202416348A (en) 2024-01-10
MX2023009314A (es) 2023-08-16
US20240408076A1 (en) 2024-12-12
WO2022173855A1 (en) 2022-08-18
CN116847843A (zh) 2023-10-03
CA3207191A1 (en) 2022-08-18
KR20240004241A (ko) 2024-01-11
US20220265634A1 (en) 2022-08-25
PE20231815A1 (es) 2023-11-16
AU2022220675A1 (en) 2023-09-21
CL2023002321A1 (es) 2024-03-08
MA61732A1 (fr) 2024-01-31

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