CN116847843A - 用于治疗快感缺乏的电压门控的钾通道开放剂 - Google Patents

用于治疗快感缺乏的电压门控的钾通道开放剂 Download PDF

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Publication number
CN116847843A
CN116847843A CN202280014279.1A CN202280014279A CN116847843A CN 116847843 A CN116847843 A CN 116847843A CN 202280014279 A CN202280014279 A CN 202280014279A CN 116847843 A CN116847843 A CN 116847843A
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S·N·皮姆斯顿
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Xenon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Shovels (AREA)
  • Ignition Installations For Internal Combustion Engines (AREA)
CN202280014279.1A 2021-02-09 2022-02-09 用于治疗快感缺乏的电压门控的钾通道开放剂 Pending CN116847843A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163147742P 2021-02-09 2021-02-09
US63/147,742 2021-02-09
PCT/US2022/015854 WO2022173855A1 (en) 2021-02-09 2022-02-09 Voltage-gated potassium channel opener for use in treating anhedonia

Publications (1)

Publication Number Publication Date
CN116847843A true CN116847843A (zh) 2023-10-03

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CN202280014279.1A Pending CN116847843A (zh) 2021-02-09 2022-02-09 用于治疗快感缺乏的电压门控的钾通道开放剂

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US (3) US11957675B2 (enExample)
EP (1) EP4291189A1 (enExample)
JP (1) JP2024508660A (enExample)
KR (1) KR20240004241A (enExample)
CN (1) CN116847843A (enExample)
AU (1) AU2022220675A1 (enExample)
CA (1) CA3207191A1 (enExample)
CL (1) CL2023002321A1 (enExample)
GE (1) GEAP202416348A (enExample)
IL (1) IL304920A (enExample)
MA (1) MA61732A1 (enExample)
MX (1) MX2023009314A (enExample)
PE (1) PE20231815A1 (enExample)
TW (1) TW202245744A (enExample)
WO (1) WO2022173855A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3155812A1 (en) 2019-11-08 2021-05-14 Cynthia Louise HARDEN Methods of treating depressive disorders
GEAP202416349A (en) * 2021-02-09 2024-02-12 Xenon Pharmaceuticals Inc Conjoint therapy for treating seizure disorders
TW202245744A (zh) 2021-02-09 2022-12-01 加拿大商再諾製藥公司 治療失樂症之方法及用途
WO2025034745A1 (en) * 2023-08-07 2025-02-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education 4-aminopiperidines as selective modulators of potassium channels
AU2024413931A1 (en) * 2023-12-28 2026-07-02 Alto Neuroscience, Inc. Compositions and methods for treating anhedonia

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101563085A (zh) * 2006-08-23 2009-10-21 威朗国际制药公司 作为钾通道调节剂的4-(n-氮杂环烷基)酰苯胺的衍生物
CN109689055A (zh) * 2016-05-25 2019-04-26 田边三菱制药株式会社 用于治疗非精神分裂症患者中的阴性症状的组合物和方法
US20190343823A1 (en) * 2018-05-11 2019-11-14 Xenon Pharmaceuticals Inc. Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener

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US11957675B2 (en) 2024-04-16
EP4291189A1 (en) 2023-12-20
TW202245744A (zh) 2022-12-01
US12171759B1 (en) 2024-12-24
US20250186426A1 (en) 2025-06-12
IL304920A (en) 2023-10-01
GEAP202416348A (en) 2024-01-10
MX2023009314A (es) 2023-08-16
US20240408076A1 (en) 2024-12-12
WO2022173855A1 (en) 2022-08-18
CA3207191A1 (en) 2022-08-18
KR20240004241A (ko) 2024-01-11
US20220265634A1 (en) 2022-08-25
PE20231815A1 (es) 2023-11-16
JP2024508660A (ja) 2024-02-28
AU2022220675A1 (en) 2023-09-21
CL2023002321A1 (es) 2024-03-08
MA61732A1 (fr) 2024-01-31

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