|
EP0672145B1
(en)
|
1992-11-24 |
2003-04-23 |
G.D. Searle & Co. |
Interleukin-3 (il-3) multiple mutation polypeptides
|
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
DE69414870T2
(de)
|
1993-09-22 |
1999-05-12 |
Medical Research Council, London |
Antikoerper mit geaenderter zielrichtung
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6562594B1
(en)
|
1999-09-29 |
2003-05-13 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
|
US6171820B1
(en)
|
1995-12-07 |
2001-01-09 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
|
US7011812B1
(en)
|
1996-05-03 |
2006-03-14 |
Immunomedics, Inc. |
Targeted combination immunotherapy of cancer and infectious diseases
|
|
AU717020B2
(en)
|
1996-05-03 |
2000-03-16 |
Immunomedics Inc. |
Targeted combination immunotherapy of cancer
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
JP4213224B2
(ja)
|
1997-05-02 |
2009-01-21 |
ジェネンテック,インコーポレーテッド |
ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法
|
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
JP2002507404A
(ja)
|
1998-03-27 |
2002-03-12 |
ジェネンテク・インコーポレイテッド |
Apo−2リガンド−抗HER−2抗体相乗作用
|
|
US7833528B2
(en)
|
1998-06-22 |
2010-11-16 |
Immunomedics, Inc. |
Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
|
|
WO2001097855A2
(en)
|
2000-06-20 |
2001-12-27 |
Immunomedics, Inc. |
Targeted combination immunotherapy of cancer and infectious diseases
|
|
US6902734B2
(en)
|
2000-08-07 |
2005-06-07 |
Centocor, Inc. |
Anti-IL-12 antibodies and compositions thereof
|
|
RU2287534C2
(ru)
|
2000-10-20 |
2006-11-20 |
Тугаи Сейяку Кабусики Кайся |
Деградированное антитело, являющееся агонистом tpo
|
|
AU2002250081A1
(en)
|
2001-02-14 |
2002-08-28 |
Uab Research Foundation |
Combined transductional and transcriptional targeting system for improved gene delivery
|
|
DE60327199D1
(de)
|
2002-04-26 |
2009-05-28 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening auf agonistische antikörper
|
|
AU2013200009B2
(en)
|
2002-07-18 |
2015-05-07 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
WO2004065611A1
(ja)
|
2003-01-21 |
2004-08-05 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の軽鎖スクリーニング方法
|
|
US8597911B2
(en)
|
2003-06-11 |
2013-12-03 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibodies
|
|
US20090191213A9
(en)
|
2003-07-02 |
2009-07-30 |
Novo Nordisk A/S |
Compositions and methods for regulating NK cell activity
|
|
WO2005030793A2
(en)
|
2003-09-24 |
2005-04-07 |
Millennium Pharmaceuticals, Inc. |
Antibodies which bind human cxcr3
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
GB0329825D0
(en)
|
2003-12-23 |
2004-01-28 |
Celltech R&D Ltd |
Biological products
|
|
US20050266425A1
(en)
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
|
WO2006063150A2
(en)
|
2004-12-08 |
2006-06-15 |
Immunomedics, Inc. |
Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer
|
|
WO2006074399A2
(en)
|
2005-01-05 |
2006-07-13 |
Biogen Idec Ma Inc. |
Multispecific binding molecules comprising connecting peptides
|
|
CN103555733A
(zh)
|
2005-01-05 |
2014-02-05 |
F-星生物技术研究与开发有限公司 |
分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
WO2007038392A2
(en)
|
2005-09-23 |
2007-04-05 |
Walter Reed Army Institute Of Research (Wrair) |
Antibodies with simultaneous subsite specificities to protein and lipid epitopes
|
|
AU2006301492B2
(en)
*
|
2005-10-11 |
2011-06-09 |
Amgen Research (Munich) Gmbh |
Compositions comprising cross-species-specific antibodies and uses thereof
|
|
HRP20150884T1
(hr)
|
2006-03-21 |
2015-09-25 |
Genentech, Inc. |
Kombinacijska terapija koja ukljuäśuje antagoniste alfa5beta1
|
|
WO2008027236A2
(en)
|
2006-08-30 |
2008-03-06 |
Genentech, Inc. |
Multispecific antibodies
|
|
GB0620729D0
(en)
|
2006-10-18 |
2006-11-29 |
Ucb Sa |
Biological products
|
|
US20090074780A1
(en)
|
2007-06-25 |
2009-03-19 |
David Urech |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
|
KR20100058509A
(ko)
|
2007-07-31 |
2010-06-03 |
메디뮨 엘엘씨 |
다중특이적 에피토프 결합 단백질 및 이의 용도
|
|
CA2697922A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
|
CL2008002856A1
(es)
|
2007-09-26 |
2009-01-16 |
Genentech Inc |
Anticuerpo novedoso (anticuerpo anti-integrina a5b1; mol}ecula de ácido nucleico que lo codifica; vector y célula huesped; método de producción; composición farmacéutica que lo comprende; su uso para inhibir la angiogénesis y/o permeabilidad vascular y cáncer entre otras patologías; y método de detección de la integrina a5b1).
|
|
EP2113255A1
(en)
|
2008-05-02 |
2009-11-04 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Cytotoxic immunoglobulin
|
|
MX345039B
(es)
|
2008-06-25 |
2017-01-16 |
Esbatech Alcon Biomed Res Unit |
Anticuerpos estables y solubles que inhiben el tnfa.
|
|
EA019512B1
(ru)
|
2008-07-02 |
2014-04-30 |
Эмерджент Продакт Дивелопмент Сиэтл, Ллс |
Il-6-опосредованная иммунотерапия
|
|
NZ590667A
(en)
|
2008-07-02 |
2013-01-25 |
Emergent Product Dev Seattle |
Tgf-b antagonist multi-target binding proteins
|
|
CN102171247A
(zh)
|
2008-07-02 |
2011-08-31 |
特鲁比昂药品公司 |
TNF-α拮抗剂多靶点结合蛋白
|
|
US20110130324A1
(en)
|
2008-07-14 |
2011-06-02 |
Uchicago Argonne, Llc |
Methods for systematic control of protein stability
|
|
WO2010014629A1
(en)
|
2008-07-28 |
2010-02-04 |
Trubion Pharmaceuticals, Inc. |
Multi-specific binding proteins targeting b cell disorders
|
|
NZ592420A
(en)
|
2008-10-02 |
2012-12-21 |
Emergent Product Dev Seattle |
Cd86 antagonist multi-target binding proteins
|
|
CN104447995A
(zh)
|
2009-03-20 |
2015-03-25 |
霍夫曼-拉罗奇有限公司 |
双特异性抗-her抗体
|
|
PE20120591A1
(es)
|
2009-04-02 |
2012-05-23 |
Roche Glycart Ag |
Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla
|
|
PL2483310T3
(pl)
|
2009-09-29 |
2015-01-30 |
Roche Glycart Ag |
Bispecyficzne przeciwciała agonistyczne dla receptora śmierci
|
|
WO2011053937A2
(en)
|
2009-10-30 |
2011-05-05 |
Bayer Healthcare Llc |
Antibody mimetic scaffolds
|
|
EP2507381A4
(en)
|
2009-12-04 |
2016-07-20 |
Hoffmann La Roche |
MULTISPECIFIC ANTIBODIES, ANTIBODY ANALOGS, COMPOSITIONS AND METHODS
|
|
CN102958942A
(zh)
|
2009-12-29 |
2013-03-06 |
新兴产品开发西雅图有限公司 |
异二聚体结合蛋白及其应用
|
|
SI2501817T2
(sl)
|
2010-02-08 |
2021-09-30 |
Regeneron Pharmaceuticals, Inc. |
Miš z navadno lahko verigo
|
|
WO2011109726A2
(en)
|
2010-03-05 |
2011-09-09 |
Bioatla Llc |
Homologous multi-specific antibodies
|
|
CN102946906B
(zh)
|
2010-04-23 |
2015-07-15 |
弗·哈夫曼-拉罗切有限公司 |
生产异源多聚体蛋白质
|
|
CN103003696B
(zh)
|
2010-07-16 |
2016-06-01 |
生物蛋白有限公司 |
蛋白演化的新方法
|
|
PL2606064T3
(pl)
|
2010-08-16 |
2015-07-31 |
Novimmune Sa |
Sposoby wytwarzania wieloswoistych i wielowartościowych przeciwciał
|
|
CA2810668A1
(en)
|
2010-09-08 |
2012-03-15 |
Halozyme, Inc. |
Methods for assessing and identifying or evolving conditionally active therapeutic proteins
|
|
PH12016502073B1
(en)
|
2010-11-17 |
2024-04-05 |
Chugai Pharmaceutical Co Ltd |
Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii
|
|
SG10201510762YA
(en)
|
2011-01-14 |
2016-01-28 |
Ucb Pharma Sa |
Antibody molecules which bind il-17a and il-17f
|
|
EP2500073A1
(en)
|
2011-03-17 |
2012-09-19 |
ChromaCon AG |
Method for identification and purification of multi-specific polypeptides
|
|
WO2012158818A2
(en)
|
2011-05-16 |
2012-11-22 |
Fabion Pharmaceuticals, Inc. |
Multi-specific fab fusion proteins and methods of use
|
|
DK2714733T3
(da)
*
|
2011-05-21 |
2019-05-06 |
Macrogenics Inc |
Cd3-bindende molekyler, der er i stand til at binde til human og ikke-human cd3
|
|
US20150045540A1
(en)
|
2011-06-28 |
2015-02-12 |
Sea Lane Biotechnologies, Llc |
Multispecific stacked variable domain binding proteins
|
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
|
EP2543680A1
(en)
|
2011-07-07 |
2013-01-09 |
Centre National de la Recherche Scientifique |
Multispecific mutated antibody Fab fragments
|
|
JP6205363B2
(ja)
|
2011-09-26 |
2017-09-27 |
ジェイエヌ バイオサイエンシーズ エルエルシー |
ハイブリッド定常領域
|
|
LT2794658T
(lt)
*
|
2011-12-19 |
2017-05-10 |
Synimmune Gmbh |
Bispecifinė antikūno molekulė
|
|
MX361875B
(es)
|
2012-03-14 |
2018-12-18 |
Regeneron Pharma |
Moléculas de unión de antígeno multiespecifícas y usos de las mismas.
|
|
US20150086584A1
(en)
|
2012-03-22 |
2015-03-26 |
University Of Miami |
Multi-specific binding agents
|
|
DK2847231T3
(da)
|
2012-05-10 |
2019-10-14 |
Bioatla Llc |
Multispecifikke monoklonale antistoffer
|
|
EP2855531A1
(en)
|
2012-05-24 |
2015-04-08 |
F. Hoffmann-La Roche AG |
Multispecific antibodies
|
|
CN104684928A
(zh)
|
2012-08-02 |
2015-06-03 |
Jn生物科学有限责任公司 |
通过半胱氨酸突变和μ尾端多聚化的抗体或融合蛋白
|
|
KR20140036905A
(ko)
|
2012-09-18 |
2014-03-26 |
삼성전자주식회사 |
이중특이 항체를 포함하는 단백질 복합체
|
|
GB201223276D0
(en)
|
2012-12-21 |
2013-02-06 |
Ucb Pharma Sa |
Antibodies and methods of producing same
|
|
CN105722859B
(zh)
*
|
2013-07-25 |
2021-05-07 |
西托姆克斯治疗公司 |
多特异性抗体、多特异性可活化抗体及其使用方法
|
|
EP2840091A1
(en)
*
|
2013-08-23 |
2015-02-25 |
MacroGenics, Inc. |
Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
|
|
US10519248B2
(en)
*
|
2014-07-25 |
2019-12-31 |
Memorial Sloan Kettering Cancer Center |
Bispecific HER2 and CD3 binding molecules
|
|
JP7020909B2
(ja)
|
2014-07-25 |
2022-02-16 |
シトムクス セラピューティクス,インコーポレイティド |
抗-cd3抗体、活性化可能抗-cd3抗体、多重特異的抗-cd3抗体、多重特異的活性化可能抗-cd3抗体、及びそれらの使用方法
|
|
MX2017006016A
(es)
*
|
2014-11-11 |
2017-06-19 |
Amunix Operating Inc |
Composiciones conjugadas de xten direccionadas y metodos para producir las mismas.
|
|
CA2973040A1
(en)
*
|
2015-01-09 |
2016-07-14 |
Mabimmune Diagnostics Ag |
Novel anti-fibroblast activation protein (fap) antibodies and uses derived thereof
|
|
AU2016222830B2
(en)
*
|
2015-02-24 |
2021-02-25 |
Bioatla Llc |
Conditionally active biological proteins
|
|
WO2017078839A1
(en)
|
2015-11-02 |
2017-05-11 |
Bioatla, Llc |
Conditionally active polypeptides
|
|
AU2016378573A1
(en)
*
|
2015-12-22 |
2018-07-19 |
Regeneron Pharmaceuticals, Inc. |
Bispecific anti-CD20/anti-CD3 antibodies to treat acute lymphoblastic leukemia
|
|
WO2017147139A1
(en)
|
2016-02-22 |
2017-08-31 |
Oceanside Biotechnology |
Neoantigen compositions and methods of using the same in immunooncotherapy
|
|
WO2017167350A1
(en)
*
|
2016-03-30 |
2017-10-05 |
Horst Lindhofer |
Multispecific antibodies for use in the treatment of a neoplasm of the urinary tract
|
|
PL3443012T3
(pl)
*
|
2016-04-15 |
2026-04-20 |
Bioatla, Inc. |
Przeciwciała anty-axl, fragmenty przeciwciał i ich immunokoniugaty oraz ich zastosowania
|
|
WO2017201731A1
(en)
*
|
2016-05-27 |
2017-11-30 |
Beijing Vdjbio Co., Ltd. |
Antibodies, composition and kits comprising same, and methods of use thereof
|
|
US9567399B1
(en)
*
|
2016-06-20 |
2017-02-14 |
Kymab Limited |
Antibodies and immunocytokines
|
|
KR102873209B1
(ko)
*
|
2016-08-31 |
2025-10-17 |
바이오아트라, 인코퍼레이티드 |
조건부 활성 폴리펩티드 및 이를 제조하는 방법
|
|
IL279399B1
(en)
*
|
2018-06-14 |
2026-04-01 |
Bioatla Llc |
Multispecific antibody templates
|
|
US20250313630A1
(en)
*
|
2022-05-27 |
2025-10-09 |
Bighat Biosciences, Inc. |
Ph-selective anti-cd3 antibodies and use of the same
|