JP2024038047A - ホモファルネシル酸の酵素的環化 - Google Patents

Abstract

【課題】ポリ不飽和カルボン酸化合物、特にホモファルネシル酸及び関連化合物の生物触媒環化によるスクラレオリド及び関連化合物の合成方法を提供する。【解決手段】立体異性的に純粋な形態での、又は立体異性体の混合物としての一般式ＩＩTIFF2024038047000033.tif3931（式中、Ｒ１、Ｒ２、Ｒ３及びＲ４は、互いに独立して、Ｈ又はＣ１～Ｃ４アルキルを表する）の化合物の生物触媒製造のための方法であって、前記化合物を、多価不飽和カルボン酸、特にホモファルネシル酸を環化することができるタンパク質と接触させる、方法である。【選択図】図１Ａ

Description

本発明は、ポリ不飽和カルボン酸化合物、特にホモファルネシル酸及び関連化合物の生物触媒的環化によるスクラレオリド及び関連化合物の製造方法に関し、ホモファルネシル酸のスクラレオリドへの生物触媒的環化によるアンブロキシドの製造方法に関する。

ドデカヒドロナフト[2,1-b]フラン骨格を有する化合物は、香料化学物質として高い経済的関心が持たれている。本件では、化合物(-)-2、すなわちアンブロキサンの左旋性立体異性体として公知の(3aR,5aS,9aS,9bR)-3a,6,6,9a-テトラメチルドデカヒドロナフト-[2,1-b]-フランについて述べるものとする。

アンブロキサンは元々マッコウクジラの竜涎香から得られるもので、現在、主に2つの経路で製造することができる。クラリーセージ(サルビア・スクラレア、Salvia sclarea)の成分であるスクラレオール(3)は、化合物((-)-2)の光学情報を既に含んでいるため、半合成材料の適切な出発原料として頻繁に使用される。ここで、酸化分解は、クロム酸、過マンガン酸塩、H₂O₂又はオゾンを用いて行うことができる[Stollら; Helv Chim Acta (1950), 33: 1251]。次に、得られたスクラレオリド(4)を(例えば、LiAlH₄又はNaBH₄を用いて)アンブロクス-1,4-ジオール(5)に変換する[Mookherjeeら; Perfumer and Flavourist (1990), 15: 27]。スクラレオール(3)からの化合物(4)の製造は、ハイフォザイマ・ロセオニジャー(Hyphozyma roseoniger) [EP 204009]による生体内変換によっても達成させることができる。

最終的に、アンブロクス-1,4-ジオール(5)を一連の化学プロセスで環化させて化合物((-)-2)を得ることができる。とりわけホモファルネシル酸[US 513,270; Luciusら; Chem Ber(1960), 93: 2663]及び4-(2,6,6-トリメチルシクロヘキセ-1-エニル)ブタン-2-オン[Buchiら; Helv Chim Acta(1989), 72: 996]を介したアンブロキサン(rac-2)のラセミ体の製造が研究されている。

2002年、アンブロキサンの市場規模は平均して年間20トンであった。これには、年間約33トンのスクラレオールの出発基質が必要である。1トンのアンブロキサンの生産には、207トンの様々な個々の物質が必要であり、その結果、206トンの廃棄物が発生する。蓄積する物質は、健康と環境に対して、異なるが全体的に比較的強力な効果を有する[ドイツ連邦環境財団（German Federal Foundation Environment）]。したがって、この合成は、多量のエネルギーを消費し、汚染化学物質の使用が必要とされる。

化合物((-)-2)の生物触媒合成は、文献[Neumannら; Biol Chem Hoppe Seyler (1986), 367:723]に記載されている。ここで、分子はホモファルネソール(化合物(1a)、(3Z,7E)-4,8,12-トリメチルトリデカ-3,7,11-トリエン-1-オール)から得られる。使用した触媒は、アリシクロバチルス・アシドカルダリウス(Alicyclobacillus acidocaldarius)(旧バチルス・アシドカルダリウス、Bacillus acidocaldarius)の酵素スクアレン-ホペンシクラーゼ(SHC)であった。ホモファルネソールのアンブロキサンへの環化を触媒するためのさらなる酵素は、特許明細書(例えばWO2012/066059)及び文献[Neumannら; loc. cit.]に記載されている。

Seitz, M.らは、ザイモモナス・モビリス(Zymomonas mobilis)からのスクアレン-ホペンシクラーゼ(Zm SHCI)を用いたホモファルネシル酸からのスクラレオリドの酵素的製造方法をChemBioChem 2013, 14, 436～439に記載している。しかしながら、そこで得られる生成物の収率はおよそ7.7～22.9%に過ぎない。

EP 204009 US 513,270 WO2012/066059

Stollら; Helv Chim Acta (1950), 33: 1251 Mookherjeeら; Perfumer and Flavourist (1990), 15: 27 Luciusら; Chem Ber(1960), 93: 2663 Buchiら; Helv Chim Acta(1989), 72: 996 Neumannら; Biol Chem Hoppe Seyler (1986), 367:723 Seitz, M.ら；ChemBioChem 2013, 14, 436～439

本発明の目的は、アンブロキシド前駆体、特にスクラレオリド及び関連化合物の改善された製造方法を提供することであった。これは従来の化学的な方法よりも技術的に簡単で経済的な様式で行うことができる(例えば、必要な反応ステップ数の減少、及び/又はより便利な出発原料)。さらなる目的は、容易に入手可能な出発原料を使用することによって、及び化学反応(又は工程)の数を減らすことによって、生じるコストをさらに低減することであった。特に、スクラレオリドの製造のための改善された生物触媒プロセスが提供されるべきである。

上記目的は、以下により詳細に説明されるように、ホモファルネシル酸誘導体、特に一般式のホモファルネシル酸(引用元)を生物触媒的に環化することを特徴とする、一般式(4)のアンブロキシド前駆体、好ましくはスクラレオリドの製造方法を提供することにより達成された。

本発明に従って調製されたホモファルネシル酸環化生成物のガスクロマトグラフィー(GC)スペクトル(A)を、市販のスクラレオリド調製物のGC(B)と比較して示す図である。 本発明に従って調製されたホモファルネシル酸環化生成物のガスクロマトグラフィー(GC)スペクトル(A)を、市販のスクラレオリド調製物のGC(B)と比較して示す図である。

A.一般的な定義
「ホモファルネシル酸」(化合物(1b))は、「(3E,7E)-4,8,12-トリメチルトリデカ-3,7,11-トリエン酸」と等価である。

「スクラレオリド」(化合物(4))は、「(3aR,5aS,9aS,9bR)-3a,6,6,9a-テトラメチル-1,4,5,5a,7,8,9,9b-オクタヒドロベンゾ[e]ベンゾフラン-2-オン」と等価である。

左旋性スクラレオリド(又は化合物(-)-4)は、以下の式を有する:

「アンブロックス(Ambrox)」、「アンブロキサン(Ambroxan)」及び「アムロキシド(Amroxide)」は、本明細書において同義語として使用される。それらは、特に(+)-アンブロックス、3a-エピ-(-)アンブロックス、9b-エピ-(-)アンブロックス、特に(-)アンブロックスのような全ての立体異性体を含む。

本発明の目的のために、「シクラーゼ」は、一般に、ホモファルネシル酸シクラーゼの活性を特に示す酵素又は酵素変異体である。ホモファルネシル酸シクラーゼの活性を有する好適な酵素は、イソメラーゼのサブクラスからの分子間トランスフェラーゼ、すなわち、EC番号EC5.4を有するタンパク質である(Eur. J. Biochem. 1999, 264, 610～650による酵素コード)。それらは、特に、EC5.4.99.17の表示である。ホモファルネシル酸シクラーゼの活性を有する適切な酵素は、特に、ホモファルネシル酸のスクラレオリドへの環化及び/又はスクアレンからホペンへの環化も引き起こすシクラーゼ(したがって時には「SHC」、スクアレン-ホペンシクラーゼという名称でもある)であり、これは本明細書に明示的に引用される国際出願PCT/EP2010/057696に詳細に記載されている。その突然変異体は、例えば、本明細書に明示的に引用されるWO2012/066059号に記載されている。

酵素反応の可逆性のために、本発明は、両方の反応方向における、本明細書に記載の酵素反応に関する。

「シクラーゼ」の「機能的突然変異体」は、本明細書において以下に定義されるそのような酵素の「機能的等価物」を含む。

「生物触媒プロセス」という用語は、本発明に係る「シクラーゼ」の触媒活性又は「シクラーゼ活性」を有する酵素の存在下で行われる任意のプロセス、すなわち粗製の、若しくは精製された、溶解された、分散されたか若しくは固定化された酵素の存在下でのプロセス、又はそのような酵素活性を有するか又は発現するインタクトな微生物細胞の存在下でのプロセスに関する。したがって、生物触媒プロセスは、酵素及び微生物プロセスを含む。

用語「立体異性体」は、立体配座異性体、特に鏡像異性体及びジアステレオ異性体のような立体配置異性体を含む。

本発明によれば、また、本明細書に記載の化合物の全ての立体異性体、例えば構造異性体、特に立体異性体及び混合立体異性体、例えば光学異性体又は幾何異性体、例えばE異性体及びZ異性体、及びこれらの組合せが、一般に、包含される。複数の不斉中心が分子内に存在する場合、本発明は、例えば鏡像異性体の対のようなこれらの不斉中心の異なる立体配座の全ての組合せを含む。

「立体特異的」という用語は、本発明に従って製造された少なくとも1つの不斉中心を有する化合物のいくつかの可能な立体異性体のうちの1つが、本発明に係る酵素の活性の結果として、例えば少なくとも90%ee、特に少なくとも95%ee、又は少なくとも98%ee、又は少なくとも99%eeなどの、高い「鏡像異性体過剰」又は「鏡像異性体純度」で生産される。ee%値は、次の式:
ee%=[X_A-X_B]/[X_A+X_B]*100,
を使用して計算され、式中X_A及びX_Bはそれぞれ鏡像異性体A及びBのモル分率である。

「標準条件下での参照基質」上で決定された「シクラーゼ活性」は、例えば、非環状基質からの環状生成物の形成を記載する酵素活性である。標準条件の例は、10mM～0.2M、特に15～100mM、例えばおよそ20～25mMの基質濃度、pH4～8、例えば15～30又は20～25℃の温度である。ここで、この決定は、組換えシクラーゼ発現細胞、破壊されたシクラーゼ発現細胞、その画分、又は富化した若しくは精製したシクラーゼ酵素を用いて行うことができる。参照基質は、特に、式(Ia)のホモファルネシル酸であり、標準条件は、特に、実施例においてもより詳細に記載されているように、およそ20～25mMの式(Ia)のホモファルネシル酸、20～25℃及びpH4～6、例えば4.5である。

本発明に係る反応の「収率」及び/又は「変換率」は、例えば、4、6、8、10、12、16、20、24、36又は48時間の規定された期間にわたって決定され、その間ホモファルネシル酸は本発明に係るシクラーゼによってスクラレオリドに変換される。特に、変換は、例えば、25、30、40、50又は60℃の厳密に規定された条件下で行われる。特に、本発明に係るシクラーゼを用いて30℃で16時間にわたってホモファルネシル酸をスクラレオリドに変換する反応を行うことにより、収率及び/又は変換を決定する。

収率及び/又は変換率を決定するために、特に10mMホモファルネシル酸溶液をシクラーゼ溶液と反応させるが、この酵素は、(例えば、[Ochs Dら; J. Bacteriol, (1992), 174: 298]に記載されるように単離された)膜タンパク質抽出物シクラーゼ発現細胞として0.08重量%のタンパク質含量濃度で存在する。

本発明に係るシクラーゼはまた、ホモファルネシル酸が同じ条件下でスクラレオリドに変換されるとき、それがアリシクロバチルス・アシドカルダリウス(旧バチルス・アシドカルダリウス)からのスクアレン-ホペンシクラーゼ(SHC)と比較して、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49、50、51、52、53、54、55、56、57、58、59、60、61、62、63、64、65、66、67、68、69、70、71、72、73、74、75、76、77、78、79、80、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、96、97、98、99、100、200、500、1000倍若しくはそれ以上の収率及び/又は変換率を示すことにも特徴付けられ得る。ここで、「条件」という用語は、基質濃度、酵素濃度、反応時間及び/又は温度などの反応条件を指す。

「カルボン酸」という用語は、遊離酸及びその塩形態、例えば、そのアルカリ又はアルカリ土類金属塩の両方を含む。これは、例えば、ホモファルネシル酸のような、本明細書で述べられる全てのカルボン酸と同様に適用される。

「およそ」という用語は、規定値の±25%、特には±15%、±10%、好ましくは±5%、±2又は±1%の起こり得る変動を示す。

「本質的に」という用語は、85～99.9%、特に90～99.9%、好ましくは95～99.9%又は98～99.9%、特に99～99.9%などの、およそ80%から100%を含む値の範囲に及ぶ。

他に示されない限り、本明細書において、以下の一般的な化学物質の定義が適用される:
「アルキル」は、1～6個、特に1～4個の、炭素原子を有する飽和直鎖又は分枝鎖、特に直鎖炭化水素基を表し、例えば、C₁～C₄アルキルの代表例として、例えば、メチル、エチル、プロピル、1-メチルエチル、ブチル、1-メチルプロピル、2-メチルプロピル及び1,1-ジメチルエチル、並びにペンチル、1-メチルブチル、2-メチルブチル、3-メチルブチル、2,2-ジメチルプロピル、1-エチルプロピル、ヘキシル、1,1-ジメチルプロピル、1,2-ジメチルプロピル、1-メチルペンチル、2-メチルペンチル、3-メチルペンチル、4-メチルペンチル、1,1-ジメチルブチル、1,2-ジメチルブチル、1,3-ジメチルブチル、2,2-ジメチルブチル、2,3-ジメチルブチル、3,3-ジメチルブチル、1-エチルブチル、2-エチルブチル、1,1,2-トリメチルプロピル、1,2,2-トリメチルプロピル、1-エチル-1-メチルプロピル及び1-エチル-2-メチルプロピル、特にメチル、エチル、n-プロピル及びn-ブチルがある。

B.本発明の特定の実施形態
本発明は、特に以下の特定の実施形態に関する:

1. 立体異性的に純粋な形態での、又は立体異性体の混合物としての一般式II

(式中、R¹、R²、R³及びR⁴は、互いに独立して、H又はC₁～C₄アルキル、特にメチル又はエチル、好ましくはメチルを表する)
の化合物の生物触媒製造のための方法であって、
前記化合物を、多価不飽和カルボン酸、特にホモファルネシル酸を環化することができるタンパク質、特にシクラーゼ活性を有するタンパク質と接触させる、方法。

2. 式Iの化合物を、スクアレン-ホペンシクラーゼ(SHC)の酵素活性を持つタンパク質と接触させる、実施形態1による方法。

3. 使用される基質が、特には本質的に立体異性的に純粋な形態の一般式I

(式中、R¹、R²、R³及びR⁴は上述の意味を有する)
の多価不飽和カルボン酸である、実施形態1又は2による方法。

4. 式Ia

のホモファルネシル酸が、出発物質として、特に本質的に立体異性的に純粋な形態で、好ましくは、存在するホモファルネシル酸異性体の総量に基づいて、少なくとも70モル%、特に好ましくは少なくとも75、80又は85モル%、最も好ましくは90、95又は99又は99.9モル%の(3E、7E)-ホモファルネシル酸の割合で使用される、上記の実施形態による方法。

5. 式IIa

のスクラレオリドが、立体異性的に純粋な形態で、又は立体異性体の混合物として得られる、実施形態4による方法。

6. 前記SHCが、
a)配列番号2のアミノ酸配列を有するポリペプチドを含むタンパク質、
b)配列番号2によるアミノ酸配列に対して、少なくとも45%、50%、55%、60%、65%、70%、特に少なくとも75%又は80%、好ましくは少なくとも85%、例えば少なくとも90、91、92、93、94、95、96、97、98又は99%の配列同一性を有するポリペプチドを含む、a)に由来したタンパク質の欠失、挿入、置換、付加、逆位、又は組合せによるタンパク質、及び
c)a)又はb)と機能的に同等であり、ホモファルネシル酸のスクラレオリドへの環化を触媒するタンパク質
から選択される、上記の実施形態のいずれか1つによる方法。

7. 機能的に等価なタンパク質が、以下から選択されるアミノ酸配列を有するポリペプチドを含む、実施形態6による方法:
a)配列番号3～326及び
b)欠失、挿入、置換、付加、逆位又は組合せによりそれから誘導され、少なくとも60%、65%、70%、特に少なくとも75%又は80%、好ましくは少なくとも85%、例えば少なくとも90、91、92、93、94、95、96、97、98又は99%の同一性の程度を有するアミノ酸配列。

8. 酵素シクラーゼ活性、特にSHCの活性が、以下から選択される形態で存在する、上記の実施形態のいずれか1つによる方法:
a)遊離の、場合により部分的又は完全に精製された天然又は組換え的に生成されたシクラーゼ、
b)固定化された形態のa)によるシクラーゼ、
c)少なくとも1つのシクラーゼを含むインタクトな細胞、
d)c)による細胞の細胞溶解物又は細胞ホモジネート。

9. 変換が、1相の水性系又は2相の水-有機系又は固体-液体系で行われる、上記の実施形態のいずれかによる方法。

10. 変換が、0～60℃、特に10～50℃、好ましくは20～40℃の温度及び/又は4～8の範囲、特に5～7の範囲のpH値で行われる、上記の実施形態のいずれかによる方法。

11. SHCが、メチロコッカス・カプサラツス(Methylococcus capsalatus)、ロドシュードモナス・パルストリス(Rhodopseudomonas palustris)、ブラジリゾビウム・ジャポニカム(Bradyrhizobium japonicum)、フランキア属(Frankia)の種、ストレプトマイセス・セリカラー(Streptomyces coelicolor)、特にザイモモナス・モビリスから選択される微生物から単離される、上記の実施形態のいずれかによる方法。

12. SHCが、エシェリキア属、コリネバクテリウム属(Corynebacterium)、ラルストニア属(Ralstonia)、クロストリジウム属(Clostridium)、シュードモナス属(Pseudomonas)、バチルス属(Bacillus)、ザイモモナス属(Zymomonas)、ロドバクター属(Rhodobacter)、ストレプトマイセス属(Streptomyces)、バークホルデリア属(Burkholderia)、ラクトバチルス属(Lactobacillus)及びラクトコッカス属(Lactococcus)の細菌の中から選択されるSHCを過剰発現する微生物から単離される、上記の実施形態のいずれかによる方法。

13. SHCは、大腸菌(Escherichia coli)、シュードモナス・プチダ(Pseudomonas putida)、バークホルデリア・グルマエ(Burkholderia glumae)、ストレプトマイセス・リビダンス(Streptomyces lividans)、ストレプトマイセス・セリカラー及びザイモモナス・モビリスの種のトランスジェニックなSHC過剰発現細菌から単離される、上記の実施形態のいずれかによる方法。

14. 変換が、回分モード、流加回分モード又は連続モードで行われる、上記の実施形態のいずれかによる方法。

15. 生物触媒による変換が、以下の条件:
a)およそ4～5.9又は5.8又は4.5～5.8、特に4.5～5.5又は5～5.5の反応媒体のpH値、
b)少なくとも15mM、例えば100mMまで、特に50mMまで、特に15～30mM、とりわけ15～25mMの基質濃度、
c)少なくとも5mg/ml、特に5～100、好ましくは10～50又は15～40又は15～30mg/mlの酵素濃度、
d)32～40℃、特に35～38℃の反応温度、
e)特に1～20mM又は5～10mMのMgCl₂を含む、クエン酸緩衝液内、特にクエン酸ナトリウム緩衝液中、
f)およそ10～100、特に20～50mMの緩衝液濃度
の少なくとも1つの下で行われる、上記の実施形態のいずれかによる方法。

本発明に係る方法は、好ましくは上記条件a)～b)又はa)～c)又はa)～d)又はa)～e)又はa)～f)を同時に実現して行う。ここでは、個別の範囲の個々の好ましさの度合いとは独立して、パラメータ範囲の任意の組合せが本開示の一部である。

16. 3a,6,6,9a-テトラメチルドデカヒドロナフト[2,1-b]フラン(アンブロキシド)の製造方法であって、
a)ホモファルネシル酸を、請求項1～13のいずれかによる方法によってスクラレオリドに変換する工程、
b)工程a)の生成物が、公知の方法でそれ自体がアンブロキシジオールに化学的に還元される工程、及び
c)工程b)からのアンブロキシドールが、公知の方法でそれ自体が化学的にアンブロキシドに環化される工程
である、方法。

17. アンブロキシドが、(-)-アンブロキシド((3aR,5aS,9aS,9bR)-3a,6,6,9a-テトラメチルドデカヒドロナフト[2,1-b]フラン[CAS 6790-58-5])である、実施形態16による方法。

C.発明のさらなる実施形態
1. 特に好適なシクラーゼ配列
本発明における有用なシクラーゼは、SHCであり、その対応する野生型配列の配列番号、供給源生物及びGenbank参照番号を以下の表にまとめた。

配列番号2は、本明細書においてZm-SHC-1とも呼ばれるシクラーゼのアミノ酸配列である。

2. 本発明に係るさらなるタンパク質/酵素変異体
本発明は、本明細書に具体的に開示されるシクラーゼ活性を有するタンパク質に限定されず、むしろその機能的等価物にも及ぶ。

具体的に開示された酵素、特に配列番号2～6の「機能的等価物」又は類似体は、本発明の範囲内であり、それらとは異なるが、所望の生物学的活性、例えば、特に、シクラーゼ活性をなお保持するポリペプチドである。

したがって、例えば、「機能的等価物」は、本発明の意味における(すなわち、標準条件下での参照基質を用いた)「シクラーゼ活性」についての使用された試験において、本明細書において具体的に定義されるアミノ酸配列(特に配列番号2～6)を含む酵素の少なくとも1%、特に少なくともおよそ5～10%、例えば少なくとも10%又は少なくとも20%、例えば少なくとも50%又は75%又は90%、より高いか又はより低い活性を有する酵素及び突然変異体を意味すると理解される。

本明細書中において、機能的等価物についての活性データは、他に特定しない限り、本明細書で定義される標準条件下で参照基質により行われる活性測定のことを言う。

本発明の意味における「シクラーゼ活性」は、様々な公知の試験を用いて検出することができる。これに限定されるものではないが、例えば本明細書の上に記載し、実験部分で説明した標準条件下で、ホモファルネシル酸のような参照基質を用いる試験を挙げるべきである。

さらに、機能的等価物は、例えばpH4～11の間で安定であり、pH5～10、特には6.5～9.5又は7～8の範囲又はおよそ7.5などの最適pHが有用であり、及び最適温度は、15℃～80℃又は20℃～70℃の範囲、例えばおよそ30～60℃又は約35～45℃、例えば40℃である。

本発明によれば、「機能的等価物」は、特に、配列番号2～326、特に配列番号2～6に由来し、上述のアミノ酸配列の少なくとも1つの配列位置において、具体的に挙げたアミノ酸以外であるが、なお上述の生物学的活性の1つを有するアミノ酸を示す「突然変異体」を意味するとも理解される。

「機能的等価物」は、アミノ酸の付加、置換、欠失及び/又は逆位などの1つ以上の、例えば1から50、2から30、2から15、4から12又は5から10の突然変異によって得られる突然変異体を含む。ここで、本発明による特性プロファイルを有する突然変異体が導かれる限り、上述の修飾は、任意の配列位置で起きてもよい。機能的等価性は、特に、変異ポリペプチドと非修飾ポリペプチドとの間の反応性パターンが品質に関して一致する場合、すなわち、例えば、同一基質が異なる速度で変換される場合にも存在する。

適切なアミノ酸置換の非限定的な例を以下の表にまとめた:

上記の意味における「機能的等価物」はまた、記載されるポリペプチドの「前駆体」であり、ポリペプチドの「機能的誘導体」及び「塩」でもある。

ここでの「前駆体」は、所望の生物学的活性を有するか又は有さないポリペプチドの天然又は合成前駆体である。

「塩」という用語は、カルボキシル基の塩だけでなく、本発明に係るタンパク質分子のアミノ基の酸付加塩も意味すると理解される。カルボキシル基の塩はそれ自体公知の方法で調製することができ、無機塩、例えばナトリウム、カルシウム、アンモニウム、鉄及び亜鉛塩、並びに有機塩基、例えばトリエタノールアミンのようなアミン、アルギニン、リシン、ピペリジンなどとの塩が含まれる。酸付加塩、例えば、塩酸又は硫酸などの鉱酸との塩、並びに酢酸及びシュウ酸などの有機酸との塩も同様に本発明の対象である。

同様に、本発明に係るポリペプチドの「機能的誘導体」は、公知の技術を用いて、機能性のアミノ酸側鎖又はそのN又はC末端で調製することができる。そのような誘導体は、例えば、カルボン酸基の脂肪族エステル、アンモニア又は第一級若しくは第二級アミンとの反応によって得ることができるカルボン酸基のアミド、アシル基との反応によって調製された遊離アミノ基のN-アシル誘導体、又はアシル基との反応によって調製される遊離ヒドロキシル基のO-アシル誘導体を含む。

もちろん「機能的等価物」は、他の生物及び天然に存在する変異体から得ることができるポリペプチドもまた含む。配列比較により、例えば、相同配列領域のエリアを確立することができ、本発明の特定の情報に基づいて相当する酵素を決定することができる。

「機能的等価物」は、例えば所望の生物学的機能を有する本発明に係るポリペプチドの断片、好ましくは個々のドメイン又は配列モチーフを同様に含む。

「機能的等価物」はさらに、上述のポリペプチド配列又はそれから誘導される機能的等価物の1つ、及び官能性N末端又はC末端結合における機能的に異なる異種配列(すなわち、融合タンパク質部分の相互的な実質的機能障害)のさらなる少なくとも1つを有する融合タンパク質である。この種の異種配列の非限定的な例は、例えば、シグナルペプチド、ヒスチジンアンカー又は酵素である。

本発明に含まれる「機能的等価物」は、具体的に開示されたタンパク質に対するホモログである。これらは、具体的に開示されたアミノ酸配列の1つに対して、例えば、90%、91%、92%、93%、94%、95%、96%、97%、98%又は99%のような、少なくとも60%、好ましくは少なくとも75%、特に少なくとも85%のPearson及びLipman、Proc. Natl. Acad, Sci.(USA)85(8)、1988、2444～2448のアルゴリズムによって計算された相同性(同一性)を有する。百分率で表現された、本発明による相同ポリペプチドの相同性又は同一性は、本明細書に具体的に記載されるアミノ酸配列の1つの全長に基づいたアミノ酸残基の百分率で表現された同一性を特に意味する。

百分率として表現される同一性データはまた、BLASTアライメント、アルゴリズムblastp(タンパク質-タンパク質BLAST)の助けを借りて、又は以下の明細書に明記されるClustal設定を適用することによって決定され得る。

タンパク質グリコシル化が可能である場合、本発明に係る「機能的等価物」は、脱グリコシル化又はグリコシル化形態の上述のタイプのタンパク質、及びグリコシル化パターンを改変することによって利用可能な修飾形態を含む。

本発明に係るタンパク質又はポリペプチドのホモログは、突然変異誘発、例えば、タンパク質の点突然変異、伸長又は切断によって生成され得る。

本発明に係るタンパク質のホモログは、例えば切断型突然変異体のような変異体のコンビナトリアルライブラリーをスクリーニングすることによって同定することができる。例えば、タンパク質変異体の多彩なライブラリーは、核酸レベルでのコンビナトリアル突然変異誘発によって、例えば、合成オリゴヌクレオチドの混合物を酵素的にライゲートすることによって生成することができる。縮重オリゴヌクレオチド配列から生じる得るホモログのライブラリーを生成するために使用することができる多くの方法が存在する。縮重遺伝子配列の化学合成は、自動DNA合成装置内で行ってもよく、その後、合成遺伝子を適切な発現ベクターにライゲートすることができる。遺伝子の縮重セットの使用により、生じる得るタンパク質配列の所望のセットをコードする全ての配列を混合物中に提供することが可能となる。縮重オリゴヌクレオチドを合成するためのプロセスは、当業者に公知である(例えば、Narang, S.A.(1983)Tetrahedron 39:3; Itakuraら(1984)Annu. Rev. Biochem. 53:323; Itakuraら、(1984)Science 198:1056; Ikeら(1983)Nucleic Acids Res. 11:477)。

点突然変異又は切断によって生成されたコンビナトリアルライブラリーの遺伝子産物をスクリーニングするための、又は選択された特性を有する遺伝子産物についてcDNAライブラリーをスクリーニングするための複数の技術が、当該技術分野で公知である。これらの技術は、本発明に係るホモログのコンビナトリアル突然変異誘発によって生成された遺伝子ライブラリーの迅速スクリーニングに適合させることができる。ハイスループット分析の基礎として、大型遺伝子ライブラリーをスクリーニングするために最も頻繁に使用される技術は、遺伝子ライブラリーを複製可能な発現ベクターにクローニングし、得られたベクターライブラリーを用いて適切な細胞を形質転換し、そして所望の活性の検出によりその産物が検出された遺伝子をコードするベクターの単離が容易となるような条件下で、コンビナトリアル遺伝子を発現させることを含む。ライブラリー中の機能的突然変異体の頻度を増加させる技術である再帰的アンサンブル突然変異誘発(Recursive Ensemble Mutagenesis、REM)は、ホモログを同定するためのスクリーニング試験と組み合わせて用いることができる(Arkin及びYourvan(1992)PNAS 89:7811～7815;Delgraveら(1993)Protein Engineering 6(3):327～331)。

3. 核酸及び構築物
3.1 核酸
上記のようにシクラーゼ活性を有する酵素をコードする核酸もまた本発明の対象である。

本発明はまた、本明細書に記載の特定の配列とある程度の同一性を有する核酸に関する。

2つの核酸間の「同一性」は、各々の場合における核酸の全長にわたるヌクレオチドの同一性、特に、以下のパラメータを設定し、Clustal法(Higgins DG、Sharp PM、マイクロコンピュータ上の高速かつ高感度の複数配列アライメント、Comput Appl. Biosci. 1989 Apr; 5(2):151～1)を用いたInformax(USA)からのVector NTI Suite 7.1ソフトウェアの支援による比較によって計算される同一性を意味すると理解される。
複数のアライメントパラメータ:
ギャップオープニングペナルティ 10
ギャップ延長ペナルティ 10
ギャップ分離ペナルティ範囲 8
ギャップ分離ペナルティ オフ
アライメント遅延の%同一性 40
残基特異的ギャップ オフ
親水性残基ギャップ オフ
遷移加重 0
ペアワイズアライメントパラメータ:
FASTアルゴリズム オン
K-tupleサイズ 1
ギャップペナルティ 3
ウィンドウサイズ 5
最良対角線の数 5

或いは、同一性は、ウェブサイト:http://www.ebi.ac.uk/Tools/clustalw/index.html#に従って、Chenna、Ramu、Sugawara、Hideaki、Koike、Tadashi、Lopez、Rodrigo、Gibson、Toby J、Higgins、Desmond G、Thompson、Julie D. Clustal系列のプログラムを用いた複数配列アラインメント(Multiple sequence alignment with the Clustal series of programs)。(2003) Nucleic Acids Res 31 (13):3497～500の方法に従い、下記のパラメータを用いて決定してもよい。
DNAギャップオープンペナルティ 15.0
DNAギャップ延長ペナルティ 6.66
DNAマトリックス アイデンティティ
プロテインギャップオープンペナルティ 10.0
タンパク質ギャップ延長ペナルティ 0.2
タンパク質マトリックス Gonnet
タンパク質/DNA ENDGAP -1
タンパク質/DNA GAPDIST 4

本明細書で言及される全ての核酸配列(例えばcDNA及びmRNAのような一本鎖及び二本鎖DNA並びにRNA配列)は、例えば、二重らせんの個々の重複した相補的な核酸基本単位のフラグメント縮合のような、ヌクレオチド基本単位の化学的な合成により、それ自体公知の方法で調製される。オリゴヌクレオチドの化学的な合成は、例えばホスホアミダイト法(Voet、Voet、2^nd ed.、Wiley Press New York、896～897)によってそれ自体公知の方法で達成することができる。合成オリゴヌクレオチドの添加及びDNAポリメラーゼのクレノウ断片の支援によるギャップの充填及びライゲーション反応並びに一般的なクローニング法は、Sambrookら(1989)、Molecular Cloning:A laboratory manual、Cold Spring Harbor Laboratory Pressに記載されている。

本発明の対象はまた、上記ポリペプチドの1つ及びそれらの機能的等価物をコードする核酸配列(例えばcDNA及びmRNAのような一本鎖及び二本鎖のDNA並びにRNA配列)であり、これは、例えば、人工ヌクレオチド類似体を使用して入手可能である。

本発明は、本発明に係るポリペプチド又はタンパク質又はその生物学的活性セグメントをコードする単離された核酸分子、及び例えばハイブリダイゼーションプローブとして又は本発明に係るコード化核酸を同定若しくは増幅するためのプライマーとして使用され得る核酸フラグメントの両方に関する。

本発明に係る核酸分子は、コード遺伝子領域の3'末端及び/又は5'末端に、非翻訳配列をさらに含み得る。

本発明はさらに、具体的に記載されたヌクレオチド配列又はそのセグメントに相補的である核酸分子を含む。

本発明に係るヌクレオチド配列により、他のタイプの細胞及び生物における相同配列を同定及び/又はクローニングするために使用され得るプローブ及びプライマーを生成することが可能となる。このようなプローブ又はプライマーは、通常、「ストリンジェントな」条件(下記参照)下で、本発明に係る核酸配列のセンス鎖又は対応するアンチセンス鎖の少なくともおよそ12個、好ましくは少なくともおよそ25個、例えばおよそ40、50又は75個の連続するヌクレオチドにハイブリダイズするヌクレオチド配列領域を含む。

「単離された」核酸分子は、核酸の天然供給源に存在する他の核酸分子から分離され、さらに、組換え技術によって調製された場合には、他の細胞材料又は培養媒体を本質的に含まなくてもよいし、化学合成された場合には、化学前駆体又は他の化学物質を本質的に含まなくてもよい。

本発明に係る核酸分子は、分子生物学の標準的な技術及び本発明により提供される配列情報を用いて単離することができる。例えば、cDNAは、ハイブリダイゼーションプローブ及び標準ハイブリダイゼーション技術として、具体的に開示された完全配列又はそのセグメントの1つを使用することにより、適切なcDNAライブラリーから単離することができる(例えば、Sambrook, J.、Fritsch, E.F.及びManiatis, T.、Molecular Cloning:A Laboratory Manual、2^nd ed.、Cold Spring Harbor Laboratory、Cold Spring Harbor Laboratory Press、Cold Spring Harbor、NY、1989に記載されるように)。さらに、開示された配列の1つ又はそのセグメントを含む核酸分子は、使用されるこの配列に基づいて生成されたオリゴヌクレオチドプライマーを用いて、ポリメラーゼ連鎖反応によって単離することができる。こうして増幅された核酸は、適切なベクターにクローニングされ、DNA配列分析によって特徴付けられ得る。本発明に係るオリゴヌクレオチドは、さらに、例えば自動DNA合成機を用いて、標準的な合成方法によって製造することができる。

本発明に係る核酸配列又はその誘導体、これらの配列のホモログ又は部分は、例えばゲノムライブラリー又はcDNAライブラリーなどの通常のハイブリダイゼーション法又はPCR技術を用いて他の細菌から単離することができる。これらのDNA配列は、標準条件下で本発明に係る配列にハイブリダイズする。

「ハイブリダイズする」とは、ポリヌクレオチド又はオリゴヌクレオチドが標準条件下でほぼ相補的な配列に結合する能力を意味すると理解されるが、これらの条件下では非相補的パートナー間の非特異的結合は起こらない。この目的のために、配列は90～100%相補的であり得る。互いに特異的に結合することができる相補的配列の特性は、例えば、ノーザンブロット若しくはサザンブロット技術又はPCR若しくはRT-PCRにおけるプライマー結合において活用される。

ハイブリダイゼーションのためには、保存領域の短いオリゴヌクレオチドが有利に使用される。しかしながら、本発明に係る核酸のより長い断片又は完全な配列もまたハイブリダイゼーションのために使用され得る。これらの標準条件は、核酸(オリゴヌクレオチド、より長い断片又は完全な配列)に依存して変化するし、又はハイブリダイゼーションにどのタイプの核酸、DNA若しくはRNAが使用されているかに依存して変化する。したがって、例えば、DNA:DNAハイブリッドの融解温度は、同じ長さのDNA:RNAハイブリッドの融解温度よりも約10℃低い。

核酸に依存して、標準条件は、例えば0.1～5×SSC(1×SSC = 0.15M NaCl、15mM クエン酸ナトリウム、pH7.2)の間の濃度を有する水性緩衝液中で42～58℃の間の温度、又は、加えて、例えば5×SSC、50%ホルムアミド中42℃のような50%ホルムアミドの存在下を意味すると理解される。有利には、DNA:DNAハイブリッドのハイブリダイゼーション条件は、0.1×SSC及びおよそ20℃～45℃、好ましくはおよそ30℃～45℃の間の温度である。DNA:RNAハイブリッドにおいては、ハイブリダイゼーション条件は、有利には0.1×SSC及びおよそ30℃～55℃、好ましくはおよそ45℃～55℃の間の温度である。ハイブリダイゼーションのこれらに述べた温度は、およそ100ヌクレオチドの長さ及びホルムアミドの非存在下で50%のG+C含量を有する核酸の計算融点値の例である。DNAハイブリダイゼーションの実験条件は、例えばSambrookら、「Molecular Cloning」、Cold Spring Harbor Laboratory、1989などの関連する遺伝学の教科書に記載されており、当業者公知の式を用いて、例えば、核酸の長さ、ハイブリッドのタイプ又はG+C含量の関数として、計算することができる。ハイブリダイゼーションについてのさらなる情報は、以下の教科書から当業者によって得ることができる:Ausubelら(eds)、1985、Current Protocols in Molecular Biology、John Wiley & Sons、New York; Hames及びHiggins (eds)、1985、Nucleic Acids Hybridization: A Practical Approach, IRL Press at Oxford University Press、Oxford; Brown (ed)、1991、Essential Molecular Biology: A Practical Approach、IRL Press at Oxford University Press、Oxford。

「ハイブリダイゼーション」は、特にストリンジェントな条件下で行うことができる。このようなハイブリダイゼーション条件は、例えば、Sambrook, J.、Fritsch, E.F.、Maniatis, T.、Molecular Cloning(A Laboratory Manual)第2版、Cold Spring Harbor Laboratory Press、1989、9.31～9.57又はCurrent Protocols in Molecular Biology、John Wiley & Sons、N.Y. (1989)、6.3.1～6.3.6に記載されている。

「ストリンジェントな」ハイブリダイゼーション条件は、特に、50%ホルムアミド、5×SSC(750mM NaCl、75mMクエン酸三ナトリウム)、50mMリン酸ナトリウム(pH7.6)、5×デンハルト溶液、10%デキストラン硫酸及び20μg/mlの変性した剪断サケ精子DNAからなる溶液中で42℃にて一晩インキュベーションし、続いて65℃で0.1×SSCでフィルターを洗浄する工程を意味するものとして解釈される。

本発明の対象はまた、具体的に開示又は誘導される核酸配列の誘導体である。

したがって、例えば、本発明に係るさらなるシクラーゼ-突然変異体をコードする核酸配列は、例えば配列番号1又は配列番号2～326、特に配列番号2～6のコード配列に由来してもよく、F486突然変異又はF486類似突然変異によるものであってもよく、個々又はいくつかのヌクレオチドの付加、置換、挿入又は欠失によって異なるが、所望の特性プロファイルを有するポリペプチドをコードし続けるものであってよい。

また、本発明によれば、核酸配列として、いわゆるサイレント突然変異を含むか、又は特定の供給源若しくは宿主生物のコドン使用に従って具体的に述べた配列を参照して修飾され、例えば、それらのスプライス変異体又は対立遺伝子変異体のような天然に存在する変異体であるようなものもまた含む。

対象は同様に、保存的ヌクレオチド置換によって得られる配列である(すなわち、問題のアミノ酸は同じ電荷、サイズ、極性及び/又は溶解度を有するアミノ酸で置換される)。

本発明の対象はまた、配列多型によって具体的に開示された核酸に由来する分子でもある。これらの遺伝的多型は、天然の変異のために集団内の個体間に存在し得る。これらの天然の変異は、通常、遺伝子のヌクレオチド配列において1～5%の変動をもたらす。

配列番号1の配列又は配列番号2～326、特に配列番号2～6のコード配列の1つに由来する本発明に係るシクラーゼをコードする核酸配列の誘導体は、例えば、配列領域全体にわたって、誘導されたアミノ酸レベルで少なくとも60%の相同性、好ましくは少なくとも80%の相同性、特に好ましくは少なくとも90%の相同性を有する対立遺伝子変異体を意味するものと理解される(アミノ酸レベルでの相同性については、ポリペプチドに関連して上記に言及したものを参照することができる)。好都合には、相同性は、配列の部分領域よりも高くなり得る。

さらに、誘導体は、本発明に係る核酸配列のホモログ、例えば、菌類又は細菌ホモログ、切断された配列、コード及び非コードDNA配列の一本鎖DNA又はRNAを意味するものと理解される。

さらに、誘導体は、例えばプロモーターとの融合物を意味するものと理解される。特定のヌクレオチド配列の上流に配置されたプロモーターは、プロモーターの機能/活性に悪影響を及ぼすことなく、少なくとも1つのヌクレオチド置換、少なくとも1つの挿入、逆位及び/又は欠失により変化したものでもよい。さらに、プロモーターの効力は、その配列を改変することによって増強され得るか、又はプロモーターは、より効果的なプロモーターのために、異なる種由来の生物からも完全に交換され得る。

3.2 機能的突然変異体の生成
さらに、当業者は、本発明に係る酵素の機能的突然変異体を生成するためのプロセスに精通している。

用いられる技術に依存して、当業者は、完全にランダムな又はより標的化された突然変異を遺伝子又は(例えば、発現調節に重要なものである)非コード核酸部位に導入し、続いて遺伝子ライブラリーを構築することができる。この目的のために必要とされる分子生物学の方法は、当業者公知であり、例えばSambrook and Russell、Molecular Cloning第3版、Cold Spring Harbor Laboratory Press 2001に記載されている。

遺伝子を改変し、それによりそれらによってコードされるタンパク質を改変する方法は、長い間当業者公知であり、例えば、
- 遺伝子の個々の又は複数のヌクレオチドが標的化された様式で置換される、部位特異的突然変異誘発(Trower MK(Ed.)1996; In vitro mutagenesis protocols、Humana Press、New Jersey)、
- 任意のアミノ酸のコドンが任意の遺伝子座で置換又は付加され得る、飽和突然変異誘発(Kegler-Ebo DM、Docktor CM、DiMaio D(1994)Nucleic Acids Res 22:1593; Barettino D、Feigenbutz M、Valcarel R、Stunnenberg HG(1994)Nucleic Acids Res 22:541; Barik S(1995)Mol. Biotechnol. 3:1)、
- 誤って作用するDNAポリメラーゼによってヌクレオチド配列が突然変異される、エラープローンポリメラーゼ連鎖反応(エラープローンPCR、error-prone PCR)(Eckert KA、Kunkel TA(1990)Nucleic Acids Res. 18:3739)、
- 優先的な置換がポリメラーゼによって妨げられる、SeSaM法(配列飽和法)。Schenkら、Biospektrum、vol.3、2006、277～279
- 例えば、ヌクレオチド配列の突然変異率の増加がDNA修復機構の欠陥のために起きるような、突然変異株における遺伝子の継代(Greener A、Callahan M、Jerpseth B(1996)An efficient random mutagenesis technique using an E. coli mutator strain. In: Trower MK (Ed.) In vitro mutagenesis protocols. Humana Press, New Jersey)、又は
- 密接に関連する遺伝子のプールが形成され、消化され、その断片がポリメラーゼ連鎖反応の鋳型として使用され、鎖分離及び再アニーリングの繰り返しによって全長のモザイク遺伝子が最終的に生成される、DNAシャッフリング。(Stemmer WPC(1994)Nature 370:389;Stemmer WPC(1994)Proc. Natl. Acad. Sci. USA 91:10747)。

「定方向進化(directed evolution)」(とりわけReetz MT及びJaeger K-E(1999)、Topics Curr. Chem. 200:31;Zhao H、Moore JC、Volkov AA、Arnold FH(1999)、Methods for optimizing industrial enzymes by directed evolution、:Demain AL, Davies JE (Ed.) Manual of industrial microbiology and biotechnology. American Society for Microbiologyに記載される)を用いて、当業者は、選択的な様式で、また大規模に機能的突然変異体を生成することができる。ここで、第1のステップにおいて、それぞれのタンパク質の遺伝子ライブラリーが最初に作製され、例えば上記に示した方法を用いることが可能である。遺伝子ライブラリーは、適切な様式で、例えば細菌又はファージディスプレイシステムによって発現される。

所望の特性にほぼ対応する特性を有する機能的突然変異体を発現する宿主生物の関連遺伝子は、さらなる突然変異のラウンドに供され得る。突然変異及び選択又はスクリーニングのステップは、存在する機能的突然変異体が適切な手段で所望の特性を有するまで繰り返して反復され得る。この繰り返し手順の結果として、限定された数の突然変異、例えば1、2、3、4又は5の突然変異を段階的に実行し、それぞれの酵素特性に対するそれらの効果について評価及び選択してもよい。次いで、選択された突然変異体は、同様の方法でさらなる突然変異工程に供され得る。それによって、研究される個々の突然変異体の数を有意に減少させることができる。

本発明による結果はまた、所望の改変された特性を有するさらなる酵素を標的化された様式で生成するために必要とされる、それぞれの酵素の構造及び配列に関して重要な情報を提供する。特に、いわゆる「ホットスポット」、すなわち標的突然変異の導入を介して酵素特性を改変するために適している可能性のある配列セグメントを規定することが可能である。

同様に、酵素活性にほとんど影響を与えないと予想される突然変異が周辺でなされている可能性があるアミノ酸配列の位置に関しての情報を導き出すこともでき、このような突然変異は、生じ得る「サイレント突然変異」と呼ぶことができる。

3.3 構築物
さらに、本発明の対象は、特には、調節核酸配列の遺伝子的な制御下に、本発明に係るポリペプチドをコードする核酸配列を含む、組換え発現構築物であり、これらの発現構築物の少なくとも1つを含む、特には組換えの、ベクターである。

本発明によれば、「発現ユニット」は、発現活性を有し、本明細書に定義されるプロモーターを含み、発現される核酸又は遺伝子に機能的に結合した後に、この核酸又はこの遺伝子の発現、換言すれば転写及び翻訳を調節する核酸のことを意味すると理解される。これは、この文脈において「調節核酸配列」とも呼ばれる理由である。プロモーターに加えて、例えばエンハンサーのようなさらなる調節エレメントが存在してもよい。

本発明によれば、「発現カセット」又は「発現構築物」は、発現される核酸又は発現される遺伝子に機能的に連結された発現ユニットを意味すると理解される。したがって、発現ユニットとは対照的に、発現カセットは、転写及び翻訳を調節する核酸配列だけでなく、転写及び翻訳の結果としてタンパク質として発現される核酸配列も含む。

本発明の文脈の中においては、用語「発現」又は「過剰発現」は、対応するDNAによってコードされた微生物中の1つ以上の酵素の細胞内活性の生成又は上昇を表す。この目的のために、例えば、遺伝子を生物に導入すること、既存の遺伝子を異なる遺伝子で置換すること、遺伝子のコピー数を増加させること、強力なプロモーターを使用すること、又は高い活性を有する対応する酵素をコードする遺伝子を使用することが可能であり、これらの手段は任意に組み合わせることができる。

好ましくは、本発明に係るそのような構築物は、それぞれのコード配列の5'上流にプロモーター配列及び3'下流にターミネーター配列、場合によってはさらなる通常の調節エレメントを含み、いずれの場合においてもコード配列に作動可能に連結されている。

本発明によれば、「プロモーター」、「プロモーター活性を有する核酸」又は「プロモーター配列」は、転写されるべき核酸と機能的に結合して、この核酸の転写を調節する核酸を意味すると理解される。

この文脈において、「機能的な」又は「作動可能な」連結とは、例えば、プロモーター活性を有する核酸の1つと転写されるべき核酸配列との連続配列、並びに場合によって、さらに、例えば核酸の転写を確実にする核酸配列及び、例えばターミネーターのような、各々が核酸配列の転写時にその機能を果たすことができるような調節エレメントを意味すると理解される。この目的のために化学的意味での直接的な連結は必ずしも必要ではない。例えば、エンハンサー配列のような遺伝子制御配列は、より遠く離れた距離の位置からの標的配列、又は実際に他のDNA分子に位置する場所からの標的配列上にそれらの機能を発揮することもできる。好ましい配列は、2つの配列が互いに共有結合するように、転写される核酸配列がプロモーター配列の後ろ(すなわち、3 '末端)に位置するものである。この文脈において、プロモーター配列とトランスジェニックに発現される核酸配列との間の距離は、200塩基対未満又は100塩基対未満又は50塩基対未満であり得る。

プロモーター及びターミネーターに加えて、他の調節要素の例としては:ターゲティング配列、エンハンサー、ポリアデニル化シグナル、選択マーカー、増幅シグナル、複製起点などが挙げられる。適切な調節配列は、例えばGoeddel、Gene Expression Technology:Methods in Enzymology 185、Academic Press、San Diego、CA(1990)に記載されている。

本発明による核酸構築物は、特に、例えば配列番号1のようなシクラーゼをコードする配列、又は配列番号2～326のようなシクラーゼをコードする配列又はその誘導体及びホモログ、並びにそれから誘導され、1つ以上の調節シグナルと作動可能なように又は機能的に連結している核酸配列を、有利には遺伝子発現を制御する、例えば増加させるために含む。

これらの調節配列に加えて、これらの配列の天然の調節が依然として実際の構造遺伝子の前に存在してもよく、場合によって、天然の調節がスイッチオフされ、遺伝子の発現が増強されるように遺伝的に改変されていてもよい。しかしながら、核酸構築物は、より簡単な構築、すなわち、コード配列の前に追加の調節シグナルが挿入されておらず、その調節を有する天然のプロモーターが除去されていないものであってもよい。代わりに、天然の調節配列は、もはや調節が起こらず、遺伝子発現が増加するように突然変異される。

好ましい核酸構築物は、有利には、プロモーターと機能的に連結している核酸配列の増強された発現を可能にする既に述べた1つ以上の「エンハンサー」配列も含む。さらなる有利な配列は、さらなる調節エレメント又はターミネーターなどのDNA配列の3 '末端に挿入されてもよい。本発明に係る核酸の1個以上のコピーは、構築物中に存在し得る。構築物において、栄養要求性又は抗生物質耐性を補完する遺伝子などの他のマーカーもまた、構築物を選択するために任意に存在し得る。

適切な調節配列の例は、cos、tac、trp、tet、trp-tet、lpp、lac、lpp-lac、lacI^q、T7、T5、T3、gal、trc、ara、rhaP(rhaP_BAD)SP6、lambda-P_R又はlambda-P_Lプロモーターのようなプロモーターに存在し、これらはグラム陰性菌に有利に用いられる。さらなる有利な調節配列は、例えば、グラム陽性プロモーターにおけるamy及びSPO2、酵母又は菌類プロモーターにおけるADC1、MFalpha、AC、P-60、CYC1、GAPDH、TEF、rp28、ADH中に存在する。人工プロモーターもまた、調節のために使用され得る。

宿主生物における発現のために、核酸構築物は、例えば、宿主中の遺伝子の最適な発現を可能にするプラスミド又はファージのようなベクターに有利に挿入される。ベクターはまた、プラスミド及びファージに加えて、当業者公知の全ての他のベクター、すなわち、例えば、SV40、CMV、バキュロウイルス及びアデノウイルスのようなウイルス、トランスポゾン、ISエレメント、ファスミド、コスミド及び直鎖又は環状DNAを意味すると理解される。これらのベクターは、宿主生物において自律的に複製され得るか、又は染色体的に複製され得る。これらのベクターは本発明のさらなる進歩である。

適当なプラスミドは、例えば、大腸菌におけるpLG338、pACYC184、pBR322、pUC18、pUC19、pKC30、pRep4、pHS1、pKK223-3、pDHE19.2、pHS2、pPLc236、pMBL24、pLG200、pUR290、pIN-III¹¹³-B1、λgt11若しくはpBdCI、ストレプトマイセスにおけるpIJ101、pIJ364、pIJ702若しくはpIJ361、バチルスにおけるpUB110、pC194若しくはpBD214、コリネバクテリウムにおけるpSA77若しくはpAJ667、菌類におけるpALS1、pIL2若しくはpBB116、酵母における2alphaM、pAG-1、YEp6、YEp13若しくはpEMBLYe23又は植物におけるpLGV23、pGHlac⁺、pBIN19、pAK2004若しくはpDH51である。上記のプラスミドは可能なプラスミドのわずかな選択範囲である。さらなるプラスミドは当業者周知であり、例えば書籍「クローニングベクター」(Eds. Pouwels P. H.らElsevier、Amsterdam-New York-Oxford、1985、ISBN 0 444 904018)に見出すことができる。

ベクターのさらなる開発において、本発明に係る核酸構築物又は本発明に係る核酸を含むベクターはまた、線状DNAの形態で微生物に有利に導入され、異種又は相同組換えを介して宿主生物のゲノムに組み込むことができる。この線状DNAは、プラスミドなどの線状化ベクター、又は本発明に係る核酸構築物又は核酸のみからなることができる。

生物体における異種遺伝子の最適な発現のためには、生物体において使用される特異的な「コドン使用頻度」に一致するように核酸配列を改変することが有利である。「コドン使用頻度」は、問題の生物の他の公知の遺伝子のコンピュータ評価によって容易に決定することができる。

本発明に係る発現カセットは、適切なプロモーターを適切なコードヌクレオチド配列及びターミネーター又はポリアデニル化シグナルに融合させることによって生成される。この目的における慣習的な組換え及びクローニング技術は、例えば、T. Maniatis、E.F. Fritsch及びJ. Sambrook、Molecular Cloning:A Laboratory Manual、Cold Spring Harbor Laboratory、Cold Spring Harbor、NY(1989)、T.J. Silhavy、M.L. Berman及びL.W. Enquist、Experiments with Gene Fusions、Cold Spring Harbor Laboratory、Cold Spring Harbor、NY(1984)並びにAusubel、F.M.ら、Current Protocols in Molecular Biology、Greene Publishing Assoc.及びWiley Interscience(1987)に記載されている。

適切な宿主生物における発現のために、組換え核酸構築物又は遺伝子構築物は、宿主内で遺伝子の最適な発現を可能にする宿主特異的ベクターに有利に挿入される。ベクターは当業者周知であり、例えば、「Cloning Vectors」(Pouwels P.H.ら、Ed.、Elsevier、Amsterdam-New York-Oxford、1985)に見出すことができる。

4. 微生物
文脈に応じて、用語「微生物」は、野生型微生物、又は遺伝子改変された組換え微生物、又はその両方のことを呼び得る。

本発明に係るベクターの助けとともに、例えば本発明に係る少なくとも1つのベクターで形質転換され、本発明に係るポリペプチドの生産に使用することができる組換え微生物を生成することが可能である。有利には、本発明に係る上記組換え構築物は、適切な宿主系に導入され、その中で発現される。この文脈において、好ましくは、例えば、共沈、プロトプラスト融合、エレクトロポレーション、レトロウイルストランスフェクションなどの当業者公知の慣習的なクローニング及びトランスフェクション方法が、問題の発現系における上述の核酸を発現させるために使用される。適切な系は、例えばCurrent Protocols in Molecular Biology、F.Ausubelら、Ed.、Wiley Interscience、New York 1997又はSambrookら、Molecular Cloning: A Laboratory Manual. 2^nd Ed.、Cold Spring Harbor Laboratory、Cold Spring Harbor Laboratory Press、Cold Spring Harbor、NY、1989に記載されている。

本発明に係る核酸又は核酸構築物のための適切な組換え宿主生物は、原理的には全ての原核生物又は真核生物である。細菌、菌類又は酵母のような微生物は、宿主生物として有利に使用される。グラム陽性菌又はグラム陰性菌、好ましくは腸内細菌科、シュードモナス科、リゾビウム科、ストレプトマイセス科又はノカルディア科からの細菌、特に好ましくはエシェリキア、シュードモナス、ストレプトマイセス、ノカルディア、バークホルデリア、サルモネラ、アグロバクテリウム、クロストリジウム又はロドコッカス属の細菌が有利に使用される。非常に特に好ましいのは、大腸菌属及び種である。さらなる有利な細菌は、アルファ-プロテオバクテリア、ベータ-プロテオバクテリア又はガンマ-プロテオバクテリアの群にさらに見出すことができる。

この文脈において、本発明に係る宿主生物は、本発明に記載され、上記に定義のフェニルエタノールデヒドロゲナーゼ活性を有する酵素をコードする核酸配列、核酸構築物又はベクターの少なくとも1つを、好ましくは含む。

宿主生物に依存して、本発明に係る方法において使用される生物は、当業者が精通したやり方で増殖又は培養される。原則として、微生物は、0から100℃の間、好ましくは10から60℃の間の温度で、酸素ガスを通過させながら、通常は糖の形態の炭素源、通常は酵母抽出物などの有機窒素源又は硫酸アンモニウムなどの塩の形態の窒素源、鉄塩、マンガン塩、マグネシウム塩のような微量元素及び場合によってはビタミンを含む液体媒体中で増殖させる。液体媒体のpHは、固定した値で維持することができ、すなわち、培養中に調節してもしなくてもよい。培養は回分式、半回分式又は連続式で行うことができる。栄養素は、発酵の開始時に提供されてもよく、半連続的又は連続的に供給されてもよい。

5. 本発明の酵素の組換え生産
本発明はさらに、ポリペプチド産生微生物を培養し、場合によりポリペプチドの発現を誘導し、ポリペプチドを培養物から単離する、本発明のポリペプチド又はその機能的に生物学的活性な断片の組換え産生方法に関する。所望の際は、このようにして工業的規模でポリペプチドを製造することもできる。

本発明に従って製造された微生物は、回分法又は流加回分法又は反復流加回分法により連続的又は不連続的に培養してもよい。公知の栽培方法の概要は、Chmielによる教科書(Bioprozesstechnik 1. Einfuhrung in die Bioverfahrenstechnik [Bioprocess technology 1. Introduction to bioprocess technology] (Gustav Fischer Verlag, Stuttgart, 1991))又はStorhasによる教科書(Bioreaktoren und periphere Einrichtungen [Bioreactors and peripheral equipment] (Vieweg Verlag, Braunschweig/Wiesbaden, 1994))に見出すことができる。

使用される培養媒体は、それぞれの株の要求を適切に満たす必要がある。種々の微生物の培養媒体の説明は、米国細菌学会(ワシントンD.C.、米国、1981)のマニュアル「一般細菌学の方法マニュアル(Manual of Methods for General Bacteriology)」に記載されている。

本発明に従って使用することができるこれらの媒体は、通常、1個以上の炭素源、窒素源、無機塩、ビタミン及び/又は微量元素を含む。

好ましい炭素源は、単糖類、二糖類又は多糖類のような糖類である。非常に良好な炭素源は、例えば、グルコース、フルクトース、マンノース、ガラクトース、リボース、ソルボース、リブロース、ラクトース、マルトース、スクロース、ラフィノース、デンプン又はセルロースである。糖はまた、糖蜜又は糖精製の他の副生成物のような複合化合物を介して媒体に添加することもできる。また、異なる炭素源の混合物を添加することも有利であり得る。他の可能な炭素源は、油脂、例えば大豆油、ヒマワリ油、ピーナッツ油、及びココナッツ油、脂肪酸、例えばパルミチン酸、ステアリン酸又はリノール酸、アルコール、例えばグリセロール、メタノール又はエタノール、及び有機酸、例えば酢酸又は乳酸である。

窒素源は、通常、有機又は無機の窒素化合物又はこれらの化合物を含む材料である。窒素源の例は、アンモニアガス又はアンモニウム塩、例えば、硫酸アンモニウム、塩化アンモニウム、リン酸アンモニウム、炭酸アンモニウム又は硝酸アンモニウム、硝酸塩、尿素、アミノ酸又は複合窒素源、例えばコーンスティープリカー、大豆粉、大豆タンパク質、酵母エキス、肉エキス等が挙げられる。窒素源は、個々に又は混合物として使用することができる。

媒体中に存在し得る無機塩化合物は、カルシウム、マグネシウム、ナトリウム、コバルト、モリブデン、カリウム、マンガン、亜鉛、銅及び鉄の塩化物、リン酸塩又は硫酸塩を含む。

硫黄源としては、無機硫黄含有化合物、例えば硫酸塩、亜硫酸塩、亜ジチオン酸塩、テトラチオン酸塩、チオ硫酸塩、硫化物並びに有機硫黄化合物、例えばメルカプタン及びチオールを使用することができる。

リン源として、リン酸、リン酸二水素カリウム又はリン酸水素二カリウム又は対応するナトリウム含有塩を使用することができる。

金属イオンを溶液中に保持するために、キレート剤を媒体に添加してもよい。特に適切なキレート剤は、カテコール又はプロトカテキン酸などのジヒドロキシフェノール、又はクエン酸のような有機酸を含む。

本発明に従って使用される発酵媒体は、例えば、ビオチン、リボフラビン、チアミン、葉酸、ニコチン酸、パントテン酸及びピリドキシンを含むビタミン又は成長促進剤のような他の成長因子も通常、含む。成長因子及び塩は、しばしば、酵母エキス、糖蜜、コーンスティープリカーなどの複合媒体の成分に由来する。さらに、適切な前駆体を培養媒体に添加することができる。媒体中の化合物の正確な組成は、それぞれの実験に大きく依存しており、特定の場合ごとに個別に決定される。媒体の最適化に関する情報は、教科書「Applied Microbiol. Physiology、A Practical Approach」(Ed. P.M. Rhodes、P.F.Stanbury、IRL Press(1997)、53～73、ISBN 0 19 963577 3)に見出すことができる。増殖媒体は、Standard 1(Merck)又はBHI(脳心臓注入、DIFCO)などのような商業的供給業者から得ることもできる。

全ての媒体成分は、加熱(1.5bar及び121℃で20分間)又はフィルター滅菌により滅菌される。これらの成分は、一緒に又は必要に応じて個別に滅菌してもよい。全ての媒体成分は、培養の開始時に存在してもよく、又は連続的に又はバッチ式に添加してもよい。

培養温度は通常15℃～45℃、好ましくは25℃～40℃であり、実験中は変化させたり一定に保つようにしたりすることができる。媒体のpHは、5～8.5の範囲、好ましくは7.0の周辺とするべきである。増殖のためのpHは、水酸化ナトリウム、水酸化カリウム、アンモニア若しくはアンモニア水のような塩基性化合物、又はリン酸若しくは硫酸のような酸性化合物を添加することによって、増殖中に制御することができる。消泡剤、例えば脂肪酸ポリグリコールエステルを、発泡を制御するために使用してもよい。プラスミドの安定性を維持するために、適切な選択的に作用する物質、例えば抗生物質を媒体に添加することができる。好気的条件を維持するために、酸素又は酸素含有ガス混合物、例えば周辺空気を培養物に通す。培養温度は普通20℃から45℃の範囲である。最大限の所望の生成物が形成されるまで、培養を続ける。この標的は普通10時間から160時間以内に到達する。

次いで、発酵液をさらに処理する。必要に応じて、バイオマスは分離技術、例えば遠心分離、濾過、デカンテーション、又はこれらの方法の組合せによって完全に又は部分的に発酵液から除去されてもよく、又は完全にその中に残されてもよい。

ポリペプチドが培養媒体に分泌されない場合、細胞を破砕してもよく、生成物は公知のタンパク質単離法によって溶解産物から得ることができる。細胞は、場合によって、高周波超音波、高圧、例えばフレンチプレス、浸透圧溶解、界面活性剤、溶菌酵素又は有機溶媒の作用、ホモジナイザーにより、又は前述の方法のいくつかの組合せにより破砕することができる。

ポリペプチドは、Q-セファロースクロマトグラフィーなどの分子ふるいクロマトグラフィー(ゲル濾過)、イオン交換クロマトグラフィー及び疎水性クロマトグラフィーなどの公知のクロマトグラフィー技術、及び限外濾過、結晶化、塩析、透析及びネイティブゲル電気泳動などの他の通常の技術を用いて精製してもよい。適切な方法は、例えば、Cooper、T.G.、Biochemische Arbeitsmethoden [Biochemical methods]、Verlag Walter de Gruyter、Berlin、New York、又はScopes、R.、Protein Purification、Springer Verlag、New York、Heidelberg、Berlinに記載されている。

組換えタンパク質の単離のためには、定義されたヌクレオチド配列によってcDNAを伸長し、したがって例えば精製を容易にする修飾ポリペプチド又は融合タンパク質をコードするベクター系又はオリゴヌクレオチドを使用することが有利であり得る。このタイプの適切な修飾は、例えば、ヘキサヒスチジンアンカーとして公知の修飾のようなアンカー、又は抗体の抗原として認識され得るエピトープとして機能する、いわゆる「タグ」である(例えば、Harlow、E.及びLane、D.、1988、Antibodies:A Laboratory Manual、Cold Spring Harbor(N.Y.)Pressに記載されている)。これらのアンカーは、固体支持体、例えば、クロマトグラフィーカラムにおける充填物として使用され得るか、又はマイクロタイタープレート若しくは他の担体上で使用され得るポリマーマトリックスへのタンパク質の結合に役立つことができる。

同時に、これらのアンカーはまた、タンパク質の認識のためにも使用され得る。タンパク質の認識のために、基質との反応後に検出可能な反応生成物を形成する蛍光色素、酵素マーカー、又は放射性マーカーのような通常のマーカーを、単独で又はタンパク質の誘導体化のためのアンカーと組み合わせて使用することもまた可能である。

本発明に係る突然変異体を発現させるために、本明細書で明示的に引用されるWO2005/108590及びWO2006/094945における、野生型酵素EbN1の発現、並びにそのために有用な発現系の説明を参照してもよい。

6. 酵素固定化
本発明に従って使用される酵素は、本明細書に記載の方法において遊離又は固定化された形態で使用することができる。固定化された酵素は、不活性担体に固定された酵素として理解されるべきである。適切な担体材料及びその上に固定された酵素は、EP-A-1149849、EP-A-1069183及びDE-A 100193773及びそこに引用されている参考文献から公知である。これに関して、これらの文献の開示は、その全体が参照により本明細書に組み込まれる。適切な担体材料としては、例えば、粘土、カオリナイトなどの粘土鉱物、珪藻土、パーライト、シリカ、酸化アルミニウム、炭酸ナトリウム、炭酸カルシウム、セルロース粉末、アニオン交換体材料、ポリスチレンやアクリル樹脂などの合成ポリマー、フェノール/ホルムアルデヒド樹脂、ポリウレタン並びにポリエチレン及びポリプロピレンのようなポリオレフィンが挙げられる。担持された酵素を作成するために、担体材料は、通常、微細に分割された粒状形態で使用され、多孔質形態が好ましい。担体材料の粒径は、通常、5mm以下、特に2mm以下(粒度分布曲線)である。同様に、全細胞触媒としてデヒドロゲナーゼを使用する場合、遊離形態又は固定形態を選択することができる。担体材料は、例えば、アルギン酸カルシウム及びカラゲナンである。酵素だけでなく細胞もまた、グルタルアルデヒドで直接架橋され得る(CLEAへの架橋)。対応する及び他の固定化技術は、例えば、J.Lalonde及びA.Margolin、「酵素の固定化(Immobilization of Enzymes)」、K. Drauz及びH. Waldmann、Enzyme Catalysis in Organic Synthesis 2002、Vol. III、991-1032、Wiley-VCH、Weinheimに記載されている。本発明に係る方法を行うためのバイオ形質転換及びバイオリアクターに関するさらなる情報は、例えば、Rehmら(Ed.)Biotechnology、2nd Edn.、Vol. 3、Chapter 17、VCH、Weinheimにおいても与えられる。

7. 多価不飽和カルボン酸の酵素的環化
7.1 一般的な態様
本発明に係る環化プロセスは、特に、酵素の存在下で行われる。ここで、酵素は、配列番号1の核酸配列又はその機能的等価物によってコードされ、核酸配列は、遺伝子構築物又はベクターの構成物である。そのような遺伝子構築物又はベクターは、国際出願PCT/EP2010/057696の16～20頁に詳細に記載されており、これは本明細書において明示的に引用される。

所望の活性を有する酵素をコードする核酸配列が存在する遺伝子構築物又はベクターを含む宿主細胞は、トランスジェニック生物とも呼ばれる。そのようなトランスジェニック生物の生成は原則的に公知であり、例えば、本明細書において明示的に引用される国際出願PCT/EP2010/057696の20頁に議論されている。

細菌、シアノバクテリア、菌類及び酵母を含む群からの細胞は、好ましくはトランスジェニック生物として選択される。細胞は、好ましくは、ピキア属の菌類又はエシェリキア属、コリネバクテリウム属、ラルストニア属、クロストリジウム属、シュードモナス属、バチルス属、ザイモモナス属、ロドバクター属、ストレプトマイセス属、バークホルデリア属、ラクトバチルス属若しくはラクトコッカス属の細菌から選択される。細胞は、特に好ましくは、大腸菌、シュードモナス・プチダ、バークホルデリア・グルマエ、ストレプトマイセス・リビダンス、ストレプトマイセス・セリカラー又はザイモモナス・モビリスの菌種から選択される。

ホモファルネシル酸シクラーゼの活性を有する酵素が、ザイモモナス・モビリス、メチロコッカス・カプスラツス(Methylococcus capsulatus) 、ロドシュードモナス・パストリス(Rhodopseudomonas palustris)、ブラディリゾビウム・ジャポニクム(Bradyrhizobium japonicum) 、フランキア属の種、ストレプトマイセス・セリカラー及びアセトバクター・ペストゥリアヌス(Acetobacter pasteurianus)から選択される微生物から単離された遺伝子によってコードされていることを特徴とする、本発明に係る方法が好ましい。ザイモモナス・モビリス、ストレプトマイセス・セリカラー、ブラディリゾビウム・ジャポニクム及びアセトバクター・ペストゥリアヌス由来の関連遺伝子が特に言及される。

さらに、シクラーゼ活性を有する酵素が、酵素を過剰に生産し、かつエシェリキア属、コリネバクテリウム属、ラルストニア属、クロストリジウム属、シュードモナス属、バチルス属、ザイモモナス属、ロドバクター属、ストレプトマイセス属、バークホルデリア属、ラクトバチルス属及びラクトコッカス属からなる微生物の群から選択される、微生物によって生成されることを特徴とする、本発明に係る方法が好ましい。

シクラーゼ活性を有する酵素が、シクラーゼ活性を有する酵素を過剰生産する大腸菌、シュードモナス・プチダ、バークホルデリア・グルマエ、コリネバクテリウム・グルタミクム(Corynebacterium glutamicum)、出芽酵母、ピキア・パストリス(Pichia pastoris)、ストレプトマイセス・リビダンス、ストレプトマイセス・セリカラー、バチルス・ズブチリス又はザイモモナス・モビリスの種のトランスジェニック微生物により生産されることを特徴とする、本発明に係る方法が特に言及される。

本発明に係る生物触媒環化方法を行うためのさらなる実施形態。

本発明に係る方法は、酵素が以下の形態の少なくとも1つで存在することを特徴とする:a)遊離の、場合により精製されたか又は部分的に精製されたポリペプチド、
b)固定されたポリペプチド、
c)a)又はb)のような細胞から単離されたポリペプチド、
d)インタクトな細胞、場合によっては、少なくとも1つのこのようなポリペプチドを含む休止細胞又は増殖細胞、
e)d)のような細胞の溶解物又はホモジネート。

本発明に係る方法のさらなる実施形態は、細胞が微生物であって、好ましくはシクラーゼ活性を有するポリペプチドをコードする少なくとも1つの異種核酸分子を発現するトランスジェニック微生物であることに特徴付けられる。

本発明に係る方法の好ましい実施形態は、少なくとも以下の工程a)、b)及びd)を含む:a)天然源からシクラーゼ活性を有する酵素を生産する微生物を単離するか又は組換えにより生成させること、
b)この微生物を増殖させること、
c)必要に応じて、微生物からシクラーゼ活性を有する酵素を単離するか、又はこの酵素を含むタンパク質画分を調製し、
d)基質、例えば一般式(Ia)のホモファルネシル酸を含む媒体中に、工程b)の微生物又は工程c)の酵素を移すこと。

本発明に係る方法において、基質、例えばホモファルネシル酸を酵素の存在下で反応させてスクラレオリドを得るように、基質を、シクラーゼ活性を有する酵素と媒体中で接触させ、及び/又はインキュベートする。媒体は、水性反応媒体であることが好ましい。

本発明に係る方法が好ましく行われる水性反応媒体のpHは、有利にはpH4から12の間、好ましくはpH4.5から9の間、特に好ましくはpH5から8の間に維持される。

水性反応媒体は、概して、好ましくは5～8のpHを有する緩衝溶液である。使用することができる緩衝液は、クエン酸塩、リン酸塩、TRIS(トリス(ヒドロキシメチル)アミノメタン)又はMES緩衝液(2-(N-モルホリノ)エタンスルホン酸)であり得る。反応媒体は、さらに、例えば、界面活性剤(例えば、タウロデオキシコール酸塩)などのさらなる添加剤をさらに含み得る。

基質、例えばホモファルネシル酸は、好ましくは2～200mM、特に好ましくは5～25mMの濃度で酵素反応に導入され、連続的又はバッチ式に補充され得る。

概して、酵素の環化は、使用される酵素の失活温度より低い-10℃を超える反応温度で起こる。好ましくは、本発明に係る方法は、0℃から95℃の間の温度、特に好ましくは15℃から60℃の間の温度、特に20℃から40℃の間、例えば約25℃から30℃の間で行われる。

ホモファルネシル酸とスクラレオリドとの反応を、20～40℃の範囲の温度及び/又は4～8の範囲のpHで行う、本発明に係る方法が特に好ましい。

これらの1相の水性系に加えて、本発明の別の変形では、2相の系もまた使用される。ここでは、水相と同様に、有機非水混和性反応媒体が第2相として使用される。結果として、反応生成物は有機相に蓄積する。反応後、有機相中の生成物は生体触媒を含む水相から容易に分離することができる。

ホモファルネシル酸の変換を1相の水性系又は2相の系で行うか、又は難溶性ホモファルネシル酸塩の変換を2相の水性/固体系中で行うことに特徴付けされる、本発明に係る方法が好ましい。

反応生成物は有機溶媒を用いて抽出することができ、場合によって精製のために蒸留することができる。

好適な有機溶媒の例は、ペンタン、シクロペンタン、ヘキサン、シクロヘキサン、ヘプタン、オクタン若しくはシクロオクタンのような好ましくは5～8個の炭素原子を有する脂肪族炭化水素、ジクロロメタン、クロロホルム、四塩化炭素、ジクロロエタン若しくはテトラクロロエタンのような好ましくは1個又は2個の炭素原子を有するハロゲン化脂肪族炭化水素、ベンゼン、トルエン、キシレン、クロロベンゼン若しくはジクロロベンゼンのような芳香族炭化水素、エタノール、イソプロパノール、ジエチルエーテル、メチルtert-ブチルエーテル、エチルtert-ブチルエーテル、ジプロピルエーテル、ジイソプロピルエーテル、ジブチルエーテル、テトラヒドロフランのような好ましくは4～8個の炭素原子を有する脂肪族非環式及び環式エーテル又はアルコール、又は酢酸エチル若しくは酢酸n-ブチルのようなエステル、又はメチルイソブチルケトン若しくはジオキサンのようなケトン、又はこれらの混合物である。上述のヘプタン、メチルtert-ブチルエーテル、ジイソプロピルエーテル、テトラヒドロフラン、酢酸エチルが特に好ましく用いられる。

本発明に従って使用されるシクラーゼは、上に既に記載したように、遊離又は固定化された酵素として本発明に係る方法において使用することができる。

本発明に係る方法のために、シクラーゼをコードする核酸、核酸構築物又はベクターを含む休止細胞又は増殖細胞、遊離細胞又は固定化細胞を使用することが可能である。細胞溶解物又は細胞ホモジネートなどの破砕された細胞もまた使用され得る。破砕細胞は、例えば、溶媒による処理によって透過処理された細胞、又は酵素処理、機械的処理(例えば、フレンチプレス又は超音波)又はいくつかの他の方法によって破砕された細胞を意味すると理解される。このようにして得られた粗抽出物は、有利には、本発明に係る方法に適している。精製された酵素又は部分的に精製された酵素もこの方法に使用することができる。

遊離の生物又は酵素が本発明に係る方法のために使用される場合、抽出の前に、例えば濾過又は遠心分離によって、便宜上、分離される。

本発明に係る方法は、バッチ式、半バッチ式又は連続式で操作することができる。

7.2 ホモファルネシル酸のスクラレオリドへの好ましい変換
特に、本発明は、スクラレオリドの製造方法であって、
a)ホモファルネシル酸をホモファルネソールアンブロキサンシクラーゼと接触させ及び/又はインキュベートし、
b)スクラレオリドが単離される、方法に関する。

本発明の一実施形態では、シクラーゼの存在下でホモファルネシル酸のスクラレオリドへの変換が起こるように、ホモファルネシル酸を媒体中でシクラーゼと共に接触させ、及び/又はインキュベートさせる。好ましくは、媒体は水性反応媒体である。好ましくは、水性反応媒体は、概して、好ましくは5～8のpHを有する緩衝溶液である。クエン酸塩、リン酸塩、TRIS(トリス(ヒドロキシメチル)アミノメタン)、MES(2-(N-モルホリノ)エタンスルホン酸)緩衝液が緩衝液として使用され得る。さらに、反応媒体は、例えば、界面活性剤(例えば、タウロデオキシコール酸塩)のような他の添加物をさらに含んでいてもよい。

基質は、好ましくは5～100mM、特に好ましくは15～25mMの濃度で酵素的変換に使用され、連続的又はバッチ式で供給され得る。

概して、酵素的環化は、使用されるシクラーゼの失活温度より低い、-10℃を超える反応温度で行われる。それは、特に好ましくは0～100℃、特に15～60℃、具体的には20～40℃、例えばおよそ30℃である。

反応生成物のスクラレオリドは、以下に述べるものの群から選択される有機溶媒で抽出することができ、場合により精製のために蒸留することができる。

これらの1相の水性系に加えて、2相の系も本発明のさらなる変形で使用される。ここでは、第2相としてイオン性液体が使用されるが、好ましくは水と混和しない有機反応媒体が第2相として適用される。それにより、反応生成物は有機相中に蓄積する。反応後、有機相中に存在するアンブロキサンは、生体触媒を含有する水相から容易に分離することができる。

非水性反応媒体は、液体反応媒体の総重量に基づいて、1重量%未満、好ましくは0.5重量%未満の水を含む反応媒体を意味すると理解される。変換は、特に有機溶媒中で行うことができる。

好適な有機溶媒の例は、ペンタン、シクロペンタン、ヘキサン、シクロヘキサン、ヘプタン、オクタン若しくはシクロオクタンのような好ましくは5～8個の炭素原子を有する脂肪族炭化水素、ジクロロメタン、クロロホルム、四塩化炭素、ジクロロエタン若しくはテトラクロロエタンのような好ましくは1個又は2個の炭素原子を有するハロゲン化脂肪族炭化水素、ベンゼン、トルエン、キシレン、クロロベンゼン若しくはジクロロベンゼンのような芳香族炭化水素、エタノール、イソプロパノール、ジエチルエーテル、メチルtert-ブチルエーテル、エチルtert-ブチルエーテル、ジプロピルエーテル、ジイソプロピルエーテル、ジブチルエーテル、テトラヒドロフランのような好ましくは4～8個の炭素原子を有する脂肪族非環式及び環式エーテル又はアルコール、又は酢酸エチル若しくは酢酸n-ブチルのようなエステル、又はメチルイソブチルケトン若しくはジオキサンのようなケトン、又はこれらの混合物である。上述のヘプタン、メチルtert-ブチルエーテル、ジイソプロピルエーテル、テトラヒドロフラン、酢酸エチルが特に好ましく用いられる。

ホモファルネシル酸のスクラレオリドへの変換は、1相の水性系だけでなく、2相系でも行うことができる。2相系の場合、上記に述べたものが使用される。第2相として水と混和しない上述の有機溶媒を使用することが好ましい。それにより、反応生成物が有機相に蓄積する。反応後、無機相にあるアンブロキサンは、生体触媒を含む水相から容易に分離することができる。

本発明のさらなる対象は、酵素が、以下からなる群から選択される少なくとも1つの核酸分子を含む核酸分子によってコードされるポリペプチドであることに特徴付けられる、スクラレオリドの生物触媒製造のための方法である:
a)配列番号2に示される配列を含むポリペプチドをコードする核酸分子、
b)少なくとも1つの配列番号1に示される配列のポリヌクレオチドを含む核酸分子、
c)その配列が配列番号2の配列に対して少なくとも45%の同一性を有するポリペプチドをコードする核酸分子、
d)配列番号2に記載の配列の機能的に等価なポリペプチド又は断片をコードする(a)～(c)に記載の核酸分子、
e)配列番号327及び328に記載のプライマーを用いてcDNAライブラリー又はゲノムDNAから核酸分子を増幅することによって得られるホモファルネシル酸シクラーゼの活性を有する機能的に等価なポリペプチドをコードする核酸分子、又はde-novo合成によって化学的に合成された核酸分子、
f)(a)～(c)に記載の核酸分子とストリンジェントな条件下でハイブリダイズする、ホモファルネシル酸シクラーゼの活性を有する機能的に等価なポリペプチドをコードする核酸分子、
g)(a)～(c)に記載の核酸分子又は少なくとも15nt、好ましくは20nt、30nt、50nt、100nt、200nt又は500ntのそのサブ断片(subfragment)をプローブとしてストリンジェントなハイブリダイゼーション条件下で用いてDNAライブラリーから単離することができる、ホモファルネシル酸シクラーゼの活性を有する機能的に等価なポリペプチドをコードする核酸分子、並びに
h)ホモファルネシル酸シクラーゼの活性を有する機能的に等価なポリペプチドをコードする核酸分子であって、そのポリペプチドの配列が配列番号2の配列に対して少なくとも30%の同一性を有する核酸分子、
i)ホモファルネシル酸シクラーゼの活性を有する機能的に等価なポリペプチドをコードする核酸分子であって、前記ポリペプチドがa)～h)に記載の核酸の群から選択される核酸分子によってコードされる、核酸分子、
j)ホモファルネシル酸シクラーゼの活性を有する機能的に等価なポリペプチドをコードする核酸分子であって、前記ポリペプチドが、a)～h)に記載のものの群から選択される核酸分子によってコードされるポリペプチドと類似又は同様の結合部位を有する、核酸分子。

本発明の目的のために、類似又は同様の結合部位は、同じ基質、特にホモファルネシル酸の結合を確実にする80%、特に好ましくは85%、86%、87%、88%、89%、90%、特に91%、92%、93%、94%、95%、96%、97%、98%又は99%又は100%の相同性を有するアミノ酸配列の保存されたドメイン又はモチーフである。

好ましくは、核酸分子c)は、配列番号1に対して少なくとも50%、60%、65%、70%、75%、80%、特に好ましくは85%、86%、87%、88%、89%、90%、特には91%、92%、93%、94%、95%、96%、97%、98%又は99%の同一性を有する。

同様に、機能的に等価なポリペプチドは、配列番号2に対して少なくとも50%、60%、65%、70%、75%、80%、特に好ましくは85%、86%、87%、88%、89%、90%、特に91%、92%、93%、94%、95%、96%、97%、98%又は99%の同一性を有する。用語「同一性」の代わりに、用語「相同性」又は「相同」もまた同義語として使用することができる。

これから本発明を以下の非限定的な実施例を参照して説明する。

実験部分
下に続く例において特定の情報が与えられない限り、下記の一般情報が適用される。

A. 一般情報
使用される全ての物質及び微生物は、市販されている製品である。

他に特定されない限り、組換えタンパク質は、例えば、Sambrook, J.、Fritsch, E.F.及びManiatis, T.、Molecular cloning:A Laboratory Manual、2^nd Edition、Cold Spring Harbor Laboratory、Cold Spring Harbor Laboratory Press、Cold Spring Harbor、NY、1989に記載されるような一般的な方法によって、クローニングされ、発現される。

B. 実施例
[実施例1]
Zm-SHCのクローニング及び大腸菌における発現
シクラーゼの遺伝子は、オリゴヌクレオチドZm-SHC_fw及びZm-SHC_revの支援を受けてザイモモナス・モビリスから増幅され得る。

各々の場合において、100ngのプライマーZm-SHC_fw及びZm-SHC_revを等モル比で混合した。Z. mobilis(ATCC31821)由来のゲノムDNAを用いたPCRを、Pwo-ポリメラーゼ(Roche Applied Science)及び以下の温度勾配プログラムを使用して製造業者の取扱説明書に従って行った:95℃で3分間、30サイクルの95℃で30秒間、50℃で30秒間及び72℃で3分間、72℃で10分間、使用するまで4℃。アガロースゲル電気泳動(1.2%電気泳動ゲル、Invitrogen)及びカラムクロマトグラフィー(GFX Kit、Amersham Pharmacia)によりPCR産物(約2.2kb)を単離し、続いて配列決定した(配列決定プライマー:Zm-SHC_fw及びZm-SHC_rev)。得られた配列は公開された配列と一致する。

PCR産物を制限エンドヌクレアーゼNdeI及びBamHIで消化し、適切に消化したベクターpDHE19.2[9]に連結した。得られたプラスミドを配列決定して、配列番号1に示される核酸配列を得た。対応するアミノ酸配列を以下のテキスト/(配列番号2)に示す。

プラスミドpDHE-Zm-SHC-1を大腸菌TG10 pAgro4 pHSG575株に形質転換した[Takeshitaら、Gene 1987, 61:63～74;Tomoyasuら、Mol Microbiol 2001, 40:397～413]。組換え大腸菌を大腸菌LU15568と命名した。

[実施例2]
Z.モビリス由来の組換えホモファルネソールシクラーゼの提供
適切な2mlの前培養から播種した大腸菌LU15568を100mlの三角フラスコ(バッフル付き)に、20mlのLB-Amp/Spec/Cm(100μg/lアンピシリン、100μg/lスペクチノマイシン、20μg/lクロラムフェニコール)、0.1mMのIPTG、0.5g/lのラムノース中、37℃で16時間増殖させ、5000×g/10分で遠心分離し、4℃で保存した。細胞ペレットを15mlの破砕緩衝液(0.2Mトリス/HCl、0.5M EDTA、pH8.0)、375Uのベンゾナーゼ(例えば、Novagen、25U/μL)、40μLのPMSF(100mM、i-PropOHに溶解したもの)、0.8gのスクロース、及びおよそ0.5mgのリゾチーム内に懸濁することにより、タンパク質抽出物を調製した。反応混合物を混合し、氷上で30分間インキュベートした。その後、-20℃で凍結させた。

反応混合物を解凍した後、蒸留水でおよそ40mlに希釈し、再び氷上で30分間インキュベートした。

その後、超音波(HTU-Soni 130、G. Heinemann、Schwabisch-Hall、振幅80%、15"パルス/15"休止)を用いて細胞を3分間3回破砕した。破砕後、細胞破片を4℃及び26900×gで60分間遠心分離することによって除去した。上清を捨て、ペレットを100mlの可溶化緩衝液(50mM Tris/HCl、10mM MgCl₂×6H₂O、1%Triton X-100、pH8.0)に再懸濁し、ポッターでおよそ5分間粉砕した。その後、懸濁液を氷上で30分間維持した。

ホモジナイズした抽出物を4℃、26900×gで1時間再度遠心分離し、ペレットを廃棄した。この抽出物を酵素アッセイに用い、活性損失が起きることなく-20℃で数週間保存することができる。タンパク質含量は1mg/mlの範囲であった。

[実施例3]
大腸菌LU15568由来の組換えシクラーゼの活性測定
ホモファルネシル酸(1b、(3E、7E)-4,8,12-トリメチルトリデカ-3,7,11-トリエン酸))を実施例2に記載のタンパク質調製物と共にインキュベートした。具体的には、0.0412gのホモファルネシル酸を秤量し(反応混合物中20mM、Z,Z 0.44%、E,Z 10.13%、E,E 74.93%からなる純度85.1%)、2.913mlの水、0.350mlのクエン酸ナトリウム緩衝液(1Mクエン酸ナトリウムpH5.4)、0.560mlのMgCl₂(0.5M溶液)をピペットで入れ、混合物を37℃で30分間撹拌しながら加温した。反応は、大腸菌LU15568ホモジネート(タンパク質含量35mg/ml)を添加して開始し、37℃に加温した。反応混合物を、pH5.0、37℃で24時間、油浴中にマグネチックスターラー上、最大撹拌速度で撹拌した。反応中、pHを0.5M HClを用いて調整した。24時間のインキュベーション後、反応混合物からの0.500mlを1000mlのn-ヘプタン/n-プロパノール 3:2を用いて30秒間ボルテックスすることにより抽出した。相分離後の有機上清をGC分析に用いた(図1参照)。

以下により詳細に記載する分析を用いて、E,E異性体から合計82.7%における74.5%の変換が測定された。

ホモファルネシル酸(引用元)のスクラレオリドへの変換(引用元)は、以下のGCシステムを用いて決定することができる:

カラム:10m Optima 1
温度プロファイル:
0分: 100℃
5℃/分で200℃まで
5分後: 30℃/分で320℃まで
その後、一定
手法の継続時間:30分
インジェクター温度:280℃
保持時間(RT):
ホモファルネシル酸:11.7分においてピーク1、12.1分においてピーク2、
スクラレオリド:およそ13.5分

未知試料の濃度を決定するためのキャリブレーション系列が、標準物質(Sigma、カタログ番号:358002)を用いて確立される。

本明細書で引用した刊行物の開示を明示的に参照する。

配列
配列番号1～326 種々のSHC遺伝子の核酸/アミノ酸配列
配列番号327～328 PCRプライマー

以下に本発明に従って特に有用なSHC酵素配列のリストを示す:

［配列表］
SEQUENCE LISTING

<110> BASF SE

<120> ENZYMATIC CYCLIZATION OF HOMOFARNESYLIC ACID

<130> PA23-643

<150> EP 16156410.9
<151> 2016-02-19

<160> 328

<210> 1
<211> 2178
<212> DNA
<213> Zymomonas mobilis

<400> 1
atgggtattg acagaatgaa tagcttaagt cgcttgttaa tgaagaagat tttcggggct 60

gaaaaaacct cgtataaacc ggcttccgat accataatcg gaacggatac cctgaaaaga 120

ccgaaccggc ggcctgaacc gacggcaaaa gtcgacaaaa cgatattcaa gactatgggg 180

aatagtctga ataataccct tgtttcagcc tgtgactggt tgatcggaca acaaaagccc 240

gatggtcatt gggtcggtgc cgtggaatcc aatgcttcga tggaagcaga atggtgtctg 300

gccttgtggt ttttgggtct ggaagatcat ccgcttcgtc caagattggg caatgctctt 360

ttggaaatgc agcgggaaga tggctcttgg ggagtctatt tcggcgctgg aaatggcgat 420

atcaatgcca cggttgaagc ctatgcggcc ttgcggtctt tggggtattc tgccgataat 480

cctgttttga aaaaagcggc agcatggatt gctgaaaaag gcggattaaa aaatatccgt 540

gtctttaccc gttattggct ggcgttgatc ggggaatggc cttgggaaaa gacccctaac 600

cttccccctg aaattatctg gttccctgat aattttgtct tttcgattta taattttgcc 660

caatgggcgc gggcaaccat ggtgccgatt gctattctgt ccgcgagacg accaagccgc 720

ccgctgcgcc ctcaagaccg attggatgaa ctgtttccag aaggccgcgc tcgctttgat 780

tatgaattgc cgaaaaaaga aggcatcgat ctttggtcgc aatttttccg aaccactgac 840

cgtggattac attgggttca gtccaatctg ttaaagcgca atagcttgcg tgaagccgct 900

atccgtcatg ttttggaatg gattatccgg catcaggatg ccgatggcgg ttggggtgga 960

attcagccac cttgggtcta tggtttgatg gcgttacatg gtgaaggcta tcagctttat 1020

catccggtga tggccaaggc tttgtcggct ttggatgatc ccggttggcg acatgacaga 1080

ggcgagtctt cttggataca ggccaccaat agtccggtat gggatacaat gttggccttg 1140

atggcgttaa aagacgccaa ggccgaggat cgttttacgc cggaaatgga taaggccgcc 1200

gattggcttt tggctcgaca ggtcaaagtc aaaggcgatt ggtcaatcaa actgcccgat 1260

gttgaacccg gtggatgggc atttgaatat gccaatgatc gctatcccga taccgatgat 1320

accgccgtcg ctttgatcgc cctttcctct tatcgtgata aggaggagtg gcaaaagaaa 1380

ggcgttgagg acgccattac ccgtggggtt aattggttga tcgccatgca aagcgaatgt 1440

ggcggttggg gagcctttga taaggataat aacagaagta tcctttccaa aattcctttt 1500

tgtgatttcg gagaatctat tgatccgcct tcagtcgatg taacggcgca tgttttagag 1560

gcctttggca ccttgggact gtcccgcgat atgccggtca tccaaaaagc gatcgactat 1620

gtccgttccg aacaggaagc cgaaggcgcg tggtttggtc gttggggcgt taattatatc 1680

tatggcaccg gtgcggttct gcctgctttg gcggcgatcg gtgaagatat gacccagcct 1740

tacatcacca aggcttgcga ttggctggtc gcacatcagc aggaagacgg cggttggggc 1800

gaaagctgct cttcctatat ggagattgat tccattggga agggcccaac cacgccgtcc 1860

cagactgctt gggctttgat ggggttgatc gcggccaatc gtcccgaaga ttatgaagcc 1920

attgccaagg gatgccatta tctgattgat cgccaagagc aggatggtag ctggaaagaa 1980

gaagaattca ccggcaccgg attccccggt tatggcgtgg gtcagacgat caagttggat 2040

gatccggctt tatcgaaacg attgcttcaa ggcgctgaac tgtcacgggc gtttatgctg 2100

cgttatgatt tttatcggca attcttcccg attatggcgt taagtcgggc agagagactg 2160

attgatttga ataattga 2178

<210> 2
<211> 725
<212> PRT
<213> Zymomonas mobilis

<400> 2
Met Gly Ile Asp Arg Met Asn Ser Leu Ser Arg Leu Leu Met Lys Lys
1 5 10 15

Ile Phe Gly Ala Glu Lys Thr Ser Tyr Lys Pro Ala Ser Asp Thr Ile
20 25 30

Ile Gly Thr Asp Thr Leu Lys Arg Pro Asn Arg Arg Pro Glu Pro Thr
35 40 45

Ala Lys Val Asp Lys Thr Ile Phe Lys Thr Met Gly Asn Ser Leu Asn
50 55 60

Asn Thr Leu Val Ser Ala Cys Asp Trp Leu Ile Gly Gln Gln Lys Pro
65 70 75 80

Asp Gly His Trp Val Gly Ala Val Glu Ser Asn Ala Ser Met Glu Ala
85 90 95

Glu Trp Cys Leu Ala Leu Trp Phe Leu Gly Leu Glu Asp His Pro Leu
100 105 110

Arg Pro Arg Leu Gly Asn Ala Leu Leu Glu Met Gln Arg Glu Asp Gly
115 120 125

Ser Trp Gly Val Tyr Phe Gly Ala Gly Asn Gly Asp Ile Asn Ala Thr
130 135 140

Val Glu Ala Tyr Ala Ala Leu Arg Ser Leu Gly Tyr Ser Ala Asp Asn
145 150 155 160

Pro Val Leu Lys Lys Ala Ala Ala Trp Ile Ala Glu Lys Gly Gly Leu
165 170 175

Lys Asn Ile Arg Val Phe Thr Arg Tyr Trp Leu Ala Leu Ile Gly Glu
180 185 190

Trp Pro Trp Glu Lys Thr Pro Asn Leu Pro Pro Glu Ile Ile Trp Phe
195 200 205

Pro Asp Asn Phe Val Phe Ser Ile Tyr Asn Phe Ala Gln Trp Ala Arg
210 215 220

Ala Thr Met Val Pro Ile Ala Ile Leu Ser Ala Arg Arg Pro Ser Arg
225 230 235 240

Pro Leu Arg Pro Gln Asp Arg Leu Asp Glu Leu Phe Pro Glu Gly Arg
245 250 255

Ala Arg Phe Asp Tyr Glu Leu Pro Lys Lys Glu Gly Ile Asp Leu Trp
260 265 270

Ser Gln Phe Phe Arg Thr Thr Asp Arg Gly Leu His Trp Val Gln Ser
275 280 285

Asn Leu Leu Lys Arg Asn Ser Leu Arg Glu Ala Ala Ile Arg His Val
290 295 300

Leu Glu Trp Ile Ile Arg His Gln Asp Ala Asp Gly Gly Trp Gly Gly
305 310 315 320

Ile Gln Pro Pro Trp Val Tyr Gly Leu Met Ala Leu His Gly Glu Gly
325 330 335

Tyr Gln Leu Tyr His Pro Val Met Ala Lys Ala Leu Ser Ala Leu Asp
340 345 350

Asp Pro Gly Trp Arg His Asp Arg Gly Glu Ser Ser Trp Ile Gln Ala
355 360 365

Thr Asn Ser Pro Val Trp Asp Thr Met Leu Ala Leu Met Ala Leu Lys
370 375 380

Asp Ala Lys Ala Glu Asp Arg Phe Thr Pro Glu Met Asp Lys Ala Ala
385 390 395 400

Asp Trp Leu Leu Ala Arg Gln Val Lys Val Lys Gly Asp Trp Ser Ile
405 410 415

Lys Leu Pro Asp Val Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn
420 425 430

Asp Arg Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Leu Ile Ala Leu
435 440 445

Ser Ser Tyr Arg Asp Lys Glu Glu Trp Gln Lys Lys Gly Val Glu Asp
450 455 460

Ala Ile Thr Arg Gly Val Asn Trp Leu Ile Ala Met Gln Ser Glu Cys
465 470 475 480

Gly Gly Trp Gly Ala Phe Asp Lys Asp Asn Asn Arg Ser Ile Leu Ser
485 490 495

Lys Ile Pro Phe Cys Asp Phe Gly Glu Ser Ile Asp Pro Pro Ser Val
500 505 510

Asp Val Thr Ala His Val Leu Glu Ala Phe Gly Thr Leu Gly Leu Ser
515 520 525

Arg Asp Met Pro Val Ile Gln Lys Ala Ile Asp Tyr Val Arg Ser Glu
530 535 540

Gln Glu Ala Glu Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile
545 550 555 560

Tyr Gly Thr Gly Ala Val Leu Pro Ala Leu Ala Ala Ile Gly Glu Asp
565 570 575

Met Thr Gln Pro Tyr Ile Thr Lys Ala Cys Asp Trp Leu Val Ala His
580 585 590

Gln Gln Glu Asp Gly Gly Trp Gly Glu Ser Cys Ser Ser Tyr Met Glu
595 600 605

Ile Asp Ser Ile Gly Lys Gly Pro Thr Thr Pro Ser Gln Thr Ala Trp
610 615 620

Ala Leu Met Gly Leu Ile Ala Ala Asn Arg Pro Glu Asp Tyr Glu Ala
625 630 635 640

Ile Ala Lys Gly Cys His Tyr Leu Ile Asp Arg Gln Glu Gln Asp Gly
645 650 655

Ser Trp Lys Glu Glu Glu Phe Thr Gly Thr Gly Phe Pro Gly Tyr Gly
660 665 670

Val Gly Gln Thr Ile Lys Leu Asp Asp Pro Ala Leu Ser Lys Arg Leu
675 680 685

Leu Gln Gly Ala Glu Leu Ser Arg Ala Phe Met Leu Arg Tyr Asp Phe
690 695 700

Tyr Arg Gln Phe Phe Pro Ile Met Ala Leu Ser Arg Ala Glu Arg Leu
705 710 715 720

Ile Asp Leu Asn Asn
725


<210> 3
<211> 680
<212> PRT
<213> Streptomyces coelicolor

<400> 3
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Ser Leu Arg Pro Leu
1 5 10 15

Ala Ala Ser Ala Ser Asp Thr Asp Ile Thr Ile Pro Ala Ala Ala Ala
20 25 30

Gly Val Pro Glu Ala Ala Ala Arg Ala Thr Arg Arg Ala Thr Asp Phe
35 40 45

Leu Leu Ala Lys Gln Asp Ala Glu Gly Trp Trp Lys Gly Asp Leu Glu
50 55 60

Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu
65 70 75 80

Gly Ile Gln Asp Glu Glu Thr Thr Arg Ala Ala Ala Leu Phe Ile Arg
85 90 95

Gly Glu Gln Arg Glu Asp Gly Thr Trp Ala Thr Phe Tyr Gly Gly Pro
100 105 110

Gly Glu Leu Ser Thr Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu Ala
115 120 125

Gly Asp Ser Pro Glu Ala Pro His Met Ala Arg Ala Ala Glu Trp Ile
130 135 140

Arg Ser Arg Gly Gly Ile Ala Ser Ala Arg Val Phe Thr Arg Ile Trp
145 150 155 160

Leu Ala Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro Glu Leu Pro
165 170 175

Pro Glu Leu Ile Tyr Phe Pro Thr Trp Val Pro Leu Asn Ile Tyr Asp
180 185 190

Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser
195 200 205

Ala Lys Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu Leu His
210 215 220

Thr Asp Pro Ala Arg Pro Asn Pro Pro Arg Pro Leu Ala Pro Val Ala
225 230 235 240

Ser Trp Asp Gly Ala Phe Gln Arg Ile Asp Lys Ala Leu His Ala Tyr
245 250 255

Arg Lys Val Ala Pro Arg Arg Leu Arg Arg Ala Ala Met Asn Ser Ala
260 265 270

Ala Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly
275 280 285

Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu Tyr Leu Leu Gly
290 295 300

Tyr Asp Leu Glu His Pro Val Met Arg Ala Gly Leu Glu Ser Leu Asp
305 310 315 320

Arg Phe Ala Val Trp Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys
325 330 335

Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp
340 345 350

Ala Gly Val Pro Glu Asp His Pro Gln Leu Val Lys Ala Ser Asp Trp
355 360 365

Met Leu Gly Glu Gln Ile Val Arg Pro Gly Asp Trp Ser Val Lys Arg
370 375 380

Pro Gly Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn
385 390 395 400

Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg
405 410 415

Val Arg His His Asp Pro Glu Arg Val Glu Lys Ala Ile Gly Arg Gly
420 425 430

Val Arg Trp Asn Leu Gly Met Gln Ser Lys Asn Gly Ala Trp Gly Ala
435 440 445

Phe Asp Val Asp Asn Thr Ser Ala Phe Pro Asn Arg Leu Pro Phe Cys
450 455 460

Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His
465 470 475 480

Val Val Glu Met Leu Ala Val Glu Gly Leu Ala His Asp Pro Arg Thr
485 490 495

Arg Arg Gly Ile Gln Trp Leu Leu Asp Ala Gln Glu Thr Asp Gly Ser
500 505 510

Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser Val
515 520 525

Ile Pro Ala Leu Thr Ala Ala Gly Leu Pro Thr Ser His Pro Ala Ile
530 535 540

Arg Arg Ala Val Arg Trp Leu Glu Ser Val Gln Asn Glu Asp Gly Gly
545 550 555 560

Trp Gly Glu Asp Leu Arg Ser Tyr Arg Tyr Val Arg Glu Trp Ser Gly
565 570 575

Arg Gly Ala Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Met Ala Leu
580 585 590

Leu Ala Ala Gly Glu Arg Asp Ser Lys Ala Val Glu Arg Gly Val Ala
595 600 605

Trp Leu Ala Ala Thr Gln Arg Glu Asp Gly Ser Trp Asp Glu Pro Tyr
610 615 620

Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr Asn Leu
625 630 635 640

Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val His Gly
645 650 655

Glu Pro Phe Ala Lys Lys Pro Arg Ala Ala Asp Ala Pro Ala Glu Ala
660 665 670

Ala Pro Ala Glu Val Lys Gly Ser
675 680


<210> 4
<211> 720
<212> PRT
<213> Acetobacter pasteurianus

<400> 4
Met Asn Met Ala Ser Arg Phe Ser Leu Lys Lys Ile Leu Arg Ser Gly
1 5 10 15

Ser Asp Thr Gln Gly Thr Asn Val Asn Thr Leu Ile Gln Ser Gly Thr
20 25 30

Ser Asp Ile Val Arg Gln Lys Pro Ala Pro Gln Glu Pro Ala Asp Leu
35 40 45

Ser Ala Leu Lys Ala Met Gly Asn Ser Leu Thr His Thr Leu Ser Ser
50 55 60

Ala Cys Glu Trp Leu Met Lys Gln Gln Lys Pro Asp Gly His Trp Val
65 70 75 80

Gly Ser Val Gly Ser Asn Ala Ser Met Glu Ala Glu Trp Cys Leu Ala
85 90 95

Leu Trp Phe Leu Gly Leu Glu Asp His Pro Leu Arg Pro Arg Leu Gly
100 105 110

Lys Ala Leu Leu Glu Met Gln Arg Pro Asp Gly Ser Trp Gly Thr Tyr
115 120 125

Tyr Gly Ala Gly Ser Gly Asp Ile Asn Ala Thr Val Glu Ser Tyr Ala
130 135 140

Ala Leu Arg Ser Leu Gly Tyr Ala Glu Asp Asp Pro Ala Val Ser Lys
145 150 155 160

Ala Ala Ala Trp Ile Ile Ser Lys Gly Gly Leu Lys Asn Val Arg Val
165 170 175

Phe Thr Arg Tyr Trp Leu Ala Leu Ile Gly Glu Trp Pro Trp Glu Lys
180 185 190

Thr Pro Asn Leu Pro Pro Glu Ile Ile Trp Phe Pro Asp Asn Phe Val
195 200 205

Phe Ser Ile Tyr Asn Phe Ala Gln Trp Ala Arg Ala Thr Met Met Pro
210 215 220

Leu Ala Ile Leu Ser Ala Arg Arg Pro Ser Arg Pro Leu Arg Pro Gln
225 230 235 240

Asp Arg Leu Asp Ala Leu Phe Pro Gly Gly Arg Ala Asn Phe Asp Tyr
245 250 255

Glu Leu Pro Thr Lys Glu Gly Arg Asp Val Ile Ala Asp Phe Phe Arg
260 265 270

Leu Ala Asp Lys Gly Leu His Trp Leu Gln Ser Ser Phe Leu Lys Arg
275 280 285

Ala Pro Ser Arg Glu Ala Ala Ile Lys Tyr Val Leu Glu Trp Ile Ile
290 295 300

Trp His Gln Asp Ala Asp Gly Gly Trp Gly Gly Ile Gln Pro Pro Trp
305 310 315 320

Val Tyr Gly Leu Met Ala Leu His Gly Glu Gly Tyr Gln Phe His His
325 330 335

Pro Val Met Ala Lys Ala Leu Asp Ala Leu Asn Asp Pro Gly Trp Arg
340 345 350

His Asp Lys Gly Asp Ala Ser Trp Ile Gln Ala Thr Asn Ser Pro Val
355 360 365

Trp Asp Thr Met Leu Ser Leu Met Ala Leu His Asp Ala Asn Ala Glu
370 375 380

Glu Arg Phe Thr Pro Glu Met Asp Lys Ala Leu Asp Trp Leu Leu Ser
385 390 395 400

Arg Gln Val Arg Val Lys Gly Asp Trp Ser Val Lys Leu Pro Asn Thr
405 410 415

Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn Asp Arg Tyr Pro Asp
420 425 430

Thr Asp Asp Thr Ala Val Ala Leu Ile Ala Ile Ala Ser Cys Arg Asn
435 440 445

Arg Pro Glu Trp Gln Ala Lys Gly Val Glu Glu Ala Ile Gly Arg Gly
450 455 460

Val Arg Trp Leu Val Ala Met Gln Ser Ser Cys Gly Gly Trp Gly Ala
465 470 475 480

Phe Asp Lys Asp Asn Asn Lys Ser Ile Leu Ala Lys Ile Pro Phe Cys
485 490 495

Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val Thr Ala His
500 505 510

Val Leu Glu Ala Phe Gly Leu Leu Gly Leu Pro Arg Asp Leu Pro Cys
515 520 525

Ile Gln Arg Gly Leu Ala Tyr Ile Arg Lys Glu Gln Asp Pro Thr Gly
530 535 540

Pro Trp Phe Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Gly Ala
545 550 555 560

Val Leu Pro Ala Leu Ala Ala Leu Gly Glu Asp Met Thr Gln Pro Tyr
565 570 575

Ile Ser Lys Ala Cys Asp Trp Leu Ile Asn Cys Gln Gln Glu Asn Gly
580 585 590

Gly Trp Gly Glu Ser Cys Ala Ser Tyr Met Glu Val Ser Ser Ile Gly
595 600 605

His Gly Ala Thr Thr Pro Ser Gln Thr Ala Trp Ala Leu Met Gly Leu
610 615 620

Ile Ala Ala Asn Arg Pro Gln Asp Tyr Glu Ala Ile Ala Lys Gly Cys
625 630 635 640

Arg Tyr Leu Ile Asp Leu Gln Glu Glu Asp Gly Ser Trp Asn Glu Glu
645 650 655

Glu Phe Thr Gly Thr Gly Phe Pro Gly Tyr Gly Val Gly Gln Thr Ile
660 665 670

Lys Leu Asp Asp Pro Ala Ile Ser Lys Arg Leu Met Gln Gly Ala Glu
675 680 685

Leu Ser Arg Ala Phe Met Leu Arg Tyr Asp Leu Tyr Arg Gln Leu Phe
690 695 700

Pro Ile Ile Ala Leu Ser Arg Ala Ser Arg Leu Ile Lys Leu Gly Asn
705 710 715 720




<210> 5
<211> 684
<212> PRT
<213> Bradyrhizobium sp.

<400> 5
Met Thr Val Thr Ser Ser Ala Ser Ala Arg Ala Thr Arg Asp Pro Gly
1 5 10 15

Asn Tyr Gln Thr Ala Leu Gln Ser Thr Val Arg Ala Ala Ala Asp Trp
20 25 30

Leu Ile Ala Asn Gln Lys Pro Asp Gly His Trp Val Gly Arg Ala Glu
35 40 45

Ser Asn Ala Cys Met Glu Ala Gln Trp Cys Leu Ala Leu Trp Phe Met
50 55 60

Gly Leu Glu Asp His Pro Leu Arg Lys Arg Leu Gly Gln Ser Leu Leu
65 70 75 80

Asp Ser Gln Arg Pro Asp Gly Ala Trp Gln Val Tyr Phe Gly Ala Pro
85 90 95

Asn Gly Asp Ile Asn Ala Thr Val Glu Ala Tyr Ala Ala Leu Arg Ser
100 105 110

Leu Gly Phe Arg Asp Asp Glu Pro Ala Val Arg Arg Ala Arg Glu Trp
115 120 125

Ile Glu Ala Lys Gly Gly Leu Arg Asn Ile Arg Val Phe Thr Arg Tyr
130 135 140

Trp Leu Ala Leu Ile Gly Glu Trp Pro Trp Glu Lys Thr Pro Asn Ile
145 150 155 160

Pro Pro Glu Val Ile Trp Phe Pro Leu Trp Phe Pro Phe Ser Ile Tyr
165 170 175

Asn Phe Ala Gln Trp Ala Arg Ala Thr Leu Met Pro Ile Ala Val Leu
180 185 190

Ser Ala Arg Arg Pro Ser Arg Pro Leu Pro Pro Glu Asn Arg Leu Asp
195 200 205

Ala Leu Phe Pro His Gly Arg Lys Ala Phe Asp Tyr Glu Leu Pro Val
210 215 220

Lys Ala Gly Ala Gly Gly Trp Asp Arg Phe Phe Arg Gly Ala Asp Lys
225 230 235 240

Val Leu His Lys Leu Gln Asn Leu Gly Asn Arg Leu Asn Leu Gly Leu
245 250 255

Phe Arg Pro Ala Ala Thr Ser Arg Val Leu Glu Trp Met Ile Arg His
260 265 270

Gln Asp Phe Asp Gly Ala Trp Gly Gly Ile Gln Pro Pro Trp Ile Tyr
275 280 285

Gly Leu Met Ala Leu Tyr Ala Glu Gly Tyr Pro Leu Asn His Pro Val
290 295 300

Leu Ala Lys Gly Leu Asp Ala Leu Asn Asp Pro Gly Trp Arg Val Asp
305 310 315 320

Val Gly Asp Ala Thr Tyr Ile Gln Ala Thr Asn Ser Pro Val Trp Asp
325 330 335

Thr Ile Leu Thr Leu Leu Ala Phe Asp Asp Ala Gly Val Leu Gly Asp
340 345 350

Tyr Pro Glu Ala Val Asp Lys Ala Val Asp Trp Val Leu Gln Arg Gln
355 360 365

Val Arg Val Pro Gly Asp Trp Ser Met Lys Leu Pro His Val Lys Pro
370 375 380

Gly Gly Trp Ala Phe Glu Tyr Ala Asn Asn Tyr Tyr Pro Asp Thr Asp
385 390 395 400

Asp Thr Ala Val Ala Leu Ile Ala Leu Ala Pro Leu Arg His Asp Pro
405 410 415

Lys Trp Lys Ala Lys Gly Ile Asp Glu Ala Ile Gln Leu Gly Val Asp
420 425 430

Trp Leu Ile Gly Met Gln Ser Gln Gly Gly Gly Trp Gly Ala Phe Asp
435 440 445

Lys Asp Asn Asn Gln Lys Ile Leu Thr Lys Ile Pro Phe Cys Asp Tyr
450 455 460

Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val Thr Ala His Ile Ile
465 470 475 480

Glu Ala Phe Gly Lys Leu Gly Ile Ser Arg Asn His Pro Ser Met Val
485 490 495

Gln Ala Leu Asp Tyr Ile Arg Arg Glu Gln Glu Pro Ser Gly Pro Trp
500 505 510

Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ala Val Leu
515 520 525

Pro Ala Leu Ala Ala Ile Gly Glu Asp Met Thr Gln Pro Tyr Ile Gly
530 535 540

Arg Ala Cys Asp Trp Leu Val Ala His Gln Gln Ala Asp Gly Gly Trp
545 550 555 560

Gly Glu Ser Cys Ala Ser Tyr Met Asp Val Ser Ala Val Gly Arg Gly
565 570 575

Thr Thr Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Ala Leu Leu Ala
580 585 590

Ala Asn Arg Pro Gln Asp Lys Asp Ala Ile Glu Arg Gly Cys Met Trp
595 600 605

Leu Val Glu Arg Gln Ser Ala Gly Thr Trp Asp Glu Pro Glu Phe Thr
610 615 620

Gly Thr Gly Phe Pro Gly Tyr Gly Val Gly Gln Thr Ile Lys Leu Asn
625 630 635 640

Asp Pro Ala Leu Ser Gln Arg Leu Met Gln Gly Pro Glu Leu Ser Arg
645 650 655

Ala Phe Met Leu Arg Tyr Gly Met Tyr Arg His Tyr Phe Pro Leu Met
660 665 670

Ala Leu Gly Arg Ala Leu Arg Pro Gln Ser His Ser
675 680


<210> 6
<211> 658
<212> PRT
<213> Zymomonas mobilis

<400> 6
Met Thr Val Ser Thr Ser Ser Ala Phe His His Ser Ser Leu Ser Asp
1 5 10 15

Asp Val Glu Pro Ile Ile Gln Lys Ala Thr Arg Ala Leu Leu Glu Lys
20 25 30

Gln His Gln Asp Gly His Trp Val Phe Glu Leu Glu Ala Asp Ala Thr
35 40 45

Ile Pro Ala Glu Tyr Ile Leu Leu Lys His Tyr Leu Gly Glu Pro Glu
50 55 60

Asp Leu Glu Ile Glu Ala Lys Ile Gly Arg Tyr Leu Arg Arg Ile Gln
65 70 75 80

Gly Glu His Gly Gly Trp Ser Leu Phe Tyr Gly Gly Asp Leu Asp Leu
85 90 95

Ser Ala Thr Val Lys Ala Tyr Phe Ala Leu Lys Met Ile Gly Asp Ser
100 105 110

Pro Asp Ala Pro His Met Leu Arg Ala Arg Asn Glu Ile Leu Ala Arg
115 120 125

Gly Gly Ala Met Arg Ala Asn Val Phe Thr Arg Ile Gln Leu Ala Leu
130 135 140

Phe Gly Ala Met Ser Trp Glu His Val Pro Gln Met Pro Val Glu Leu
145 150 155 160

Met Leu Met Pro Glu Trp Phe Pro Val His Ile Asn Lys Met Ala Tyr
165 170 175

Trp Ala Arg Thr Val Leu Val Pro Leu Leu Val Leu Gln Ala Leu Lys
180 185 190

Pro Val Ala Arg Asn Arg Arg Gly Ile Leu Val Asp Glu Leu Phe Val
195 200 205

Pro Asp Val Leu Pro Thr Leu Gln Glu Ser Gly Asp Pro Ile Trp Arg
210 215 220

Arg Phe Phe Ser Ala Leu Asp Lys Val Leu His Lys Val Glu Pro Tyr
225 230 235 240

Trp Pro Lys Asn Met Arg Ala Lys Ala Ile His Ser Cys Val His Phe
245 250 255

Val Thr Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro
260 265 270

Ala Ile Ala Asn Ser Val Met Met Tyr Asp Ala Leu Gly Tyr Pro Glu
275 280 285

Asn His Pro Glu Arg Ala Ile Ala Arg Arg Ala Val Glu Lys Leu Met
290 295 300

Val Leu Asp Gly Thr Glu Asp Gln Gly Asp Lys Glu Val Tyr Cys Gln
305 310 315 320

Pro Cys Leu Ser Pro Ile Trp Asp Thr Ala Leu Val Ala His Ala Met
325 330 335

Leu Glu Val Gly Gly Asp Glu Ala Glu Lys Ser Ala Ile Ser Ala Leu
340 345 350

Ser Trp Leu Lys Pro Gln Gln Ile Leu Asp Val Lys Gly Asp Trp Ala
355 360 365

Trp Arg Arg Pro Asp Leu Arg Pro Gly Gly Trp Ala Phe Gln Tyr Arg
370 375 380

Asn Asp Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val Val Thr Met Ala
385 390 395 400

Met Asp Arg Ala Ala Lys Leu Ser Asp Leu His Asp Asp Phe Glu Glu
405 410 415

Ser Lys Ala Arg Ala Met Glu Trp Thr Ile Gly Met Gln Ser Asp Asn
420 425 430

Gly Gly Trp Gly Ala Phe Asp Ala Asn Asn Ser Tyr Thr Tyr Leu Asn
435 440 445

Asn Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Val
450 455 460

Asp Val Ser Ala Arg Cys Val Ser Met Met Ala Gln Ala Gly Ile Ser
465 470 475 480

Ile Thr Asp Pro Lys Met Lys Ala Ala Val Asp Tyr Leu Leu Lys Glu
485 490 495

Gln Glu Glu Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile
500 505 510

Tyr Gly Thr Trp Ser Ala Leu Cys Ala Leu Asn Val Ala Ala Leu Pro
515 520 525

His Asp His Leu Ala Ile Gln Lys Ala Val Ala Trp Leu Lys Asn Ile
530 535 540

Gln Asn Glu Asp Gly Gly Trp Gly Glu Asn Cys Asp Ser Tyr Ala Leu
545 550 555 560

Asp Tyr Ser Gly Tyr Glu Pro Met Asp Ser Thr Ala Ser Gln Thr Ala
565 570 575

Trp Ala Leu Leu Gly Leu Met Ala Val Gly Glu Ala Asn Ser Glu Ala
580 585 590

Val Thr Lys Gly Ile Asn Trp Leu Ala Gln Asn Gln Asp Glu Glu Gly
595 600 605

Leu Trp Lys Glu Asp Tyr Tyr Ser Gly Gly Gly Phe Pro Arg Val Phe
610 615 620

Tyr Leu Arg Tyr His Gly Tyr Ser Lys Tyr Phe Pro Leu Trp Ala Leu
625 630 635 640

Ala Arg Tyr Arg Asn Leu Lys Lys Ala Asn Gln Pro Ile Val His Tyr
645 650 655

Gly Met


<210> 7
<211> 648
<212> PRT
<213> Acidithiobacillus caldus

<400> 7
Met Asn Pro Val Val His Asn Leu Thr Arg Pro His Arg Ser Ala Glu
1 5 10 15

Pro Arg Pro Ser Ala Leu Gln Arg Ser Ile Ala Ala Ala Gln Ala Ala
20 25 30

Leu Leu Gln His Gln Ala Ala Asp Gly His Trp Cys Phe Glu Phe Glu
35 40 45

Ala Asp Cys Thr Ile Pro Ala Glu Tyr Ile Leu Met Met His Tyr Met
50 55 60

Asp Glu Arg Asp Ala Ala Leu Glu Ala Lys Met Ala Ala Tyr Leu Arg
65 70 75 80

Arg Lys Gln Glu Asn His Gly Gly Trp Ser Leu Tyr His Gly Gly His
85 90 95

Phe Asp Met Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Leu Ala
100 105 110

Gly Asp Asp Pro Glu Ala Ala His Met Arg Arg Ala Arg Ser Ala Ile
115 120 125

Leu Ala His Gly Gly Ala Glu Arg Ala Asn Val Phe Thr Arg Ile Thr
130 135 140

Leu Ala Leu Phe Gly Gln Val Pro Trp Arg Ala Val Pro Phe Ile Pro
145 150 155 160

Val Glu Ile Leu Leu Phe Pro Arg Trp Phe Pro Met His Ile Tyr Lys
165 170 175

Val Ala Ser Trp Ser Arg Thr Val Met Val Pro Leu Phe Ile Leu Cys
180 185 190

Ser Leu Lys Pro Gln Ala Lys Asn Pro Leu Gly Val His Ile Arg Glu
195 200 205

Leu Phe Thr Arg Pro Pro Glu Asp Ile Asp Asp Tyr Phe Ala His Ala
210 215 220

Leu Gln Gly Trp Val Ser Arg Ile Phe Leu Trp Phe Asp Arg Leu Gly
225 230 235 240

Arg Ala Leu Glu Ser Trp Ile Pro Gln Ala Leu Arg Arg Arg Ala Ile
245 250 255

Ala Arg Ala Glu Ala Trp Phe Ile Glu Arg Leu Asn Gly Glu Asp Gly
260 265 270

Leu Asn Gly Ile Phe Pro Ala Met Val Asn Ala His Glu Ala Leu Ala
275 280 285

Leu Leu Gly Tyr Ala Ala Glu His Pro Tyr Arg Gln Gln Thr Arg Ala
290 295 300

Ala Leu Thr Lys Leu Val Val Glu Arg Ala Gly Glu Ala Tyr Cys Gln
305 310 315 320

Pro Cys Val Ser Pro Val Trp Asp Thr Cys Leu Ala Leu His Ala Leu
325 330 335

Leu Glu Ala Asp Gly Asp Val Ser Glu Ala Ala Arg Arg Ser Met Gln
340 345 350

Trp Leu Leu Asp Arg Gln Ile Thr Asp Ala Pro Gly Asp Trp Arg Glu
355 360 365

Arg Arg Pro His Leu Ala Gly Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Pro Tyr Tyr Pro Asp Leu Asp Asp Thr Ala Ala Val Ala Trp Ala Leu
385 390 395 400

Ala Arg Ala Arg Arg Pro Glu Asp Arg Pro Ala Val Glu Arg Ala Ala
405 410 415

Asn Trp Leu Ala Gly Met Gln Ser Arg Asn Gly Gly Phe Gly Ala Tyr
420 425 430

Asp Val Asp Asn Thr Tyr Tyr Tyr Leu Asn Glu Ile Pro Phe Ala Asp
435 440 445

His Lys Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser Gly Arg Val
450 455 460

Leu Ala Phe Leu Ala Ile Leu Asp Arg Glu Gln Asp Ala Pro Val Arg
465 470 475 480

Ala Arg Leu Ile Gln Tyr Leu Leu Arg Glu Gln Glu Pro Ser Gly Ala
485 490 495

Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val
500 505 510

Leu Met Gly Met Ala Glu Leu Arg Asp Pro Gly Ala Glu Val Arg Asp
515 520 525

Ala Met Ala Arg Ala Ala His Trp Leu Arg Ser Val Gln Gln Asp Asp
530 535 540

Gly Gly Trp Gly Glu Ser Asn Asp Ser Tyr Ala Asp Pro Gly Leu Ala
545 550 555 560

Gly Leu Gly Gln Glu Ser Thr Ala Ala Gln Thr Ala Trp Ala Cys Leu
565 570 575

Ala Leu Met Ala Ala Gly Asp Ser Asp Ser Glu Ser Leu Arg Arg Gly
580 585 590

Ile Gln Trp Leu Gln Arg His Gln Glu Gln Pro Gly Asp Trp Gln Asp
595 600 605

Pro Tyr Phe Asn Ala Pro Gly Phe Pro Arg Val Phe Tyr Leu Thr Tyr
610 615 620

His Gly Tyr Lys Ile Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg
625 630 635 640

Asn Ile Thr Glu Arg His Cys Ala
645


<210> 8
<211> 643
<212> PRT
<213> Acidithiobacillus ferrooxidans

<400> 8
Met Asn Arg Met Leu Gln Pro Leu His Ser Gly Ala Gly Ile Phe Arg
1 5 10 15

Ser Ser Leu Asp Arg Val Ile Ala Gln Ala Arg Gln Ala Leu Gly Gly
20 25 30

Arg Gln Ala Glu Asp Gly His Trp Cys Phe Glu Phe Glu Ala Asp Cys
35 40 45

Thr Ile Pro Ala Glu Tyr Ile Leu Met Gln His Tyr Met Asp Glu Arg
50 55 60

Asp Glu Ala Leu Glu Ala Arg Ile Ala Val Tyr Leu Arg Gly Lys Gln
65 70 75 80

Ala Asp His Gly Gly Trp Pro Leu Tyr Tyr Gly Gly His Phe Asp Leu
85 90 95

Ser Ala Ser Val Lys Val Tyr Tyr Ala Leu Lys Leu Ala Gly Asp Asp
100 105 110

Pro Glu Leu Pro His Met Arg Arg Ala Arg Glu Ala Ile Leu Ala His
115 120 125

Gly Gly Ala Glu Arg Ser Asn Val Phe Thr Arg Ile Thr Leu Ala Leu
130 135 140

Phe Ala Gln Val Pro Trp Arg Ala Val Pro Phe Ile Pro Val Glu Ile
145 150 155 160

Met Leu Leu Pro Arg Trp Phe Pro Phe His Ile Tyr Lys Val Ala Ser
165 170 175

Trp Ser Arg Thr Val Met Val Pro Leu Phe Ile Leu Cys Ser Leu Lys
180 185 190

Ala Arg Ala Lys Asn Pro Leu Gln Val His Ile Arg Glu Leu Phe Arg
195 200 205

Arg Pro Pro Asp Gln Ile Thr Asp Tyr Phe Ser His Ala Arg Arg Gly
210 215 220

Ile Val Ala Tyr Ile Phe Leu Ser Leu Asp Arg Phe Trp Arg Leu Met
225 230 235 240

Glu Gly Trp Ile Pro His Gly Ile Arg Arg Arg Ala Leu Lys Lys Ala
245 250 255

Glu Ala Trp Phe Thr Ala Arg Ile Asn Gly Glu Asp Gly Leu Asn Gly
260 265 270

Ile Phe Pro Ala Met Val Asn Ala His Glu Ala Leu Glu Leu Leu Gly
275 280 285

Tyr Pro Pro Asp His Asp Tyr Arg Arg Gln Thr Gly Ala Ala Leu Arg
290 295 300

Lys Leu Val Val Glu Arg Ala Asn Asp Ala Tyr Cys Gln Pro Cys Val
305 310 315 320

Ser Pro Val Trp Asp Thr Cys Leu Ala Leu His Ala Leu Leu Glu Glu
325 330 335

Asp Gly Glu Val Ser Pro Ala Val Gln Asn Gly Ile Arg Trp Leu Lys
340 345 350

Asn Arg Gln Ile Gly Ala Glu Pro Gly Asp Trp Arg Glu Ser Arg Pro
355 360 365

His Leu Ala Gly Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Ala Val Gly Trp Ala Leu Ala Arg Ala
385 390 395 400

Gly Arg Ala Glu Asp Arg Asp Ser Ile Glu Lys Ala Ala Asn Trp Leu
405 410 415

Ala Gly Met Gln Ser Arg Asn Gly Gly Phe Gly Ala Tyr Asp Val Asp
420 425 430

Asn Thr His Tyr Tyr Leu Asn Glu Ile Pro Phe Ala Asp His Lys Ala
435 440 445

Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Gly Arg Val Val Ala Phe
450 455 460

Leu Ala His Leu Ala Arg Pro Arg Asp Arg Asp Val Leu Arg Arg Ala
465 470 475 480

Val Ala Tyr Leu Leu Arg Glu Gln Glu Ser Ser Gly Ala Trp Phe Gly
485 490 495

Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Met Ala
500 505 510

Leu Ala Glu Leu Asn Asp Pro Ser Leu Lys Pro Thr Met Glu Arg Ala
515 520 525

Ala Tyr Trp Leu Arg Ala Val Gln Gln Gly Asp Gly Gly Trp Gly Glu
530 535 540

Ser Asn Asp Ser Tyr Ser Asp Pro Gly Leu Ala Gly Met Gly Gln Thr
545 550 555 560

Ser Thr Ala Ala Gln Thr Ala Trp Ala Cys Leu Gly Leu Met Ala Ala
565 570 575

Gly Asp Arg Asp Ser Val Ala Leu His Arg Gly Ile Ala Trp Leu Gln
580 585 590

Ala His Gln Glu Gly Asp Gly Cys Trp Gln Ala Pro Phe Phe Asn Ala
595 600 605

Pro Gly Phe Pro Lys Val Phe Tyr Leu Ile Tyr His Gly Tyr Ala Phe
610 615 620

Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu Gly Cys Met
625 630 635 640

Ala His Glu


<210> 9
<211> 679
<212> PRT
<213> Acidobacterium capsulatum

<400> 9
Met Ser Val Ser Glu Arg Ala Gln Pro Gly Gly Asn Pro Ile Pro Gly
1 5 10 15

Ser Thr Ser Gln Ser Ala Val Lys Phe Gly Arg Ile Asp Ala Ala Leu
20 25 30

Glu Asp Val Lys Arg Ala Ile Ala Gly Ala Lys Asp Arg Val Phe Ala
35 40 45

Gln Gln Ser Lys Asp Gly Trp Trp Cys Gly Glu Leu Glu Ala Asp Ser
50 55 60

Met Leu Glu Ala Asp Tyr Ile Phe Ala His Thr Leu Leu Gly Thr Gly
65 70 75 80

Asp Ala Gly Lys Met Lys Arg Ala Leu Thr Glu Met Leu Arg Tyr Gln
85 90 95

Asn Glu Asp Gly Ser Trp Ser Ile Tyr Pro Gly Gly Pro Gly Asn Ile
100 105 110

Ser Leu Thr Val Lys Cys Tyr Phe Ser Ala Lys Leu Met Gly Met Thr
115 120 125

Ala Asp Asn Pro Ile Leu Val Lys Ala Arg Glu Trp Ile Leu Ala His
130 135 140

Gly Gly Val Val Glu Cys Asn Thr Phe Thr Lys Ile Tyr Leu Cys Phe
145 150 155 160

Leu Gly Gln Tyr Glu Tyr Asp Ala Val Pro Ala Ile Pro Pro Glu Ile
165 170 175

Val Leu Phe Pro Asn Trp Phe Tyr Phe Asn Ile Tyr Glu Ile Ser Ser
180 185 190

Trp Ser Arg Ala Ile Leu Val Pro Leu Ser Ile Ala Tyr Ala Lys Lys
195 200 205

Pro Phe Lys Lys Ile Pro Pro Glu Gln Gly Ile Asp Glu Leu Phe Val
210 215 220

Gly Gly Arg Glu Lys Ala Asn Leu His Leu Arg Trp Asp Ser Lys Asn
225 230 235 240

Leu Leu Ser Trp Arg Asn Phe Phe Leu Ala Leu Asp Arg Val Thr His
245 250 255

Trp Phe Glu Arg Val His Ile Arg Pro Leu Arg Ser Ile Ala Leu Lys
260 265 270

Lys Ala Glu Lys Trp Met Leu Ala Arg Phe Glu Met Ser Asp Gly Leu
275 280 285

Gly Ala Ile Tyr Pro Ala Met Leu Asn Ala Ile Ile Ala Leu Arg Cys
290 295 300

Leu Gly Tyr Ser Leu Asp Asp Pro Gln Val Leu Arg Ala Met Asp Glu
305 310 315 320

Phe Glu Lys Leu Gly Ile Asp Glu Pro Glu Gly Thr Ala Glu Tyr Ala
325 330 335

Glu Pro Thr Phe Arg Met Gln Pro Cys Val Ser Pro Val Trp Asp Thr
340 345 350

Ala Gln Ala Val Phe Ala Leu Gly Glu Ala Gly Val Pro Arg Asn Asp
355 360 365

Pro Arg Met Gln Lys Ala Ala Asp Trp Leu Leu Ser Lys Glu Val Arg
370 375 380

His Lys Gly Asp Trp Ala Met Lys Val Arg Asn Ala Gln Pro Gly Gly
385 390 395 400

Trp Tyr Phe Glu Phe Asn Asn Glu Phe Tyr Pro Asp Val Asp Asp Ser
405 410 415

Ala Gln Val Leu Leu Ala Leu Asn Lys Val Asp Asn Pro Arg Glu Arg
420 425 430

Tyr Gln Tyr Asp Val Cys Gln Arg Ala Ile Asp Trp Ile Phe Ala Met
435 440 445

Gln Cys Arg Asn Gly Gly Trp Ala Ser Phe Asp Lys Asp Asn Thr Lys
450 455 460

Met Ile Phe Gln Tyr Val Pro Phe Ala Asp His Asn Ala Met Leu Asp
465 470 475 480

Pro Pro Thr Val Asp Ile Thr Gly Arg Ile Leu Glu Met Leu Ala Thr
485 490 495

Tyr Gly Tyr Thr Arg Lys Asp Arg Arg Val Glu Lys Ala Ile Lys Phe
500 505 510

Ile Tyr Asp Glu Gln Glu Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly
515 520 525

Val Asn Tyr Leu Tyr Gly Thr Phe Leu Val Leu Arg Gly Leu Glu Ala
530 535 540

Ile Gly Val Trp Asn His Glu Pro Gln Ile Gln Gln Ala Ala Glu Trp
545 550 555 560

Ile Arg Ser Val Gln Asn Ala Asp Gly Gly Trp Gly Glu Thr Cys Gly
565 570 575

Ser Tyr Asp Asp Pro Asn Thr Arg Gly Val Gly Pro Ser Thr Pro Ser
580 585 590

Gln Thr Ala Trp Ala Ile Leu Gly Leu Leu Ser Ala Gly Asp Asp Arg
595 600 605

Ser Asp Ser Val Ala Lys Gly Ile Lys Trp Leu Leu Ala His Gln Lys
610 615 620

Pro Asp Gly Gly Trp Asp Glu Ser Thr Gly Ser Gly Ser Lys His Gln
625 630 635 640

Ala Leu Tyr Thr Gly Thr Gly Phe Pro Arg Val Phe Tyr Leu Ala Tyr
645 650 655

His Gln Tyr Arg Asp Tyr Phe Pro Leu Leu Ala Leu Thr Asn Tyr Glu
660 665 670

Lys Ala Met Glu Arg Gly Glu
675


<210> 10
<211> 633
<212> PRT
<213> Acidothermus cellulolyticus

<400> 10
Met Thr Gln Ala Ser Val Arg Glu Asp Ala Lys Ala Ala Leu Asp Arg
1 5 10 15

Ala Val Asp Tyr Leu Leu Ser Leu Gln Asp Glu Lys Gly Phe Trp Lys
20 25 30

Gly Glu Leu Glu Thr Asn Val Thr Ile Glu Ala Glu Asp Leu Leu Leu
35 40 45

Arg Glu Phe Leu Gly Ile Arg Thr Pro Asp Ile Thr Ala Glu Thr Ala
50 55 60

Arg Trp Ile Arg Ala Lys Gln Arg Ser Asp Gly Thr Trp Ala Thr Phe
65 70 75 80

Tyr Asp Gly Pro Pro Asp Leu Ser Thr Ser Val Glu Ala Tyr Val Ala
85 90 95

Leu Lys Leu Ala Gly Asp Asp Pro Ala Ala Pro His Met Glu Lys Ala
100 105 110

Ala Ala Tyr Ile Arg Gly Ala Gly Gly Val Glu Arg Thr Arg Val Phe
115 120 125

Thr Arg Leu Trp Leu Ala Leu Phe Gly Leu Trp Pro Trp Asp Asp Leu
130 135 140

Pro Thr Leu Pro Pro Glu Met Ile Phe Leu Pro Ser Trp Phe Pro Leu
145 150 155 160

Asn Ile Tyr Asp Trp Gly Cys Trp Ala Arg Gln Thr Val Val Pro Leu
165 170 175

Thr Ile Val Ser Ala Leu Arg Pro Val Arg Pro Ile Pro Leu Ser Ile
180 185 190

Asp Glu Ile Arg Thr Gly Ala Pro Pro Pro Pro Arg Asp Pro Ala Trp
195 200 205

Thr Ile Arg Gly Phe Phe Gln Arg Leu Asp Asp Leu Leu Arg Gly Tyr
210 215 220

Arg Arg Val Ala Asp His Gly Pro Ala Arg Leu Phe Arg Arg Leu Ala
225 230 235 240

Met Arg Arg Ala Ala Glu Trp Ile Ile Ala Arg Gln Glu Ala Asp Gly
245 250 255

Ser Trp Gly Gly Ile Gln Pro Pro Trp Val Tyr Ser Leu Ile Ala Leu
260 265 270

His Leu Leu Gly Tyr Pro Leu Asp His Pro Val Leu Arg Arg Gly Leu
275 280 285

Asp Gly Leu Asn Gly Phe Thr Ile Arg Glu Glu Thr Ala Asp Gly Ala
290 295 300

Val Arg Arg Leu Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Ala Leu
305 310 315 320

Ala Val Thr Ala Leu Arg Asp Ala Gly Leu Pro Ala Asp His Pro Arg
325 330 335

Val Gln Ala Ala Ala Arg Trp Leu Val Gly Glu Glu Val Arg Val Ala
340 345 350

Gly Asp Trp Ala Val Arg Arg Pro Gly Leu Pro Pro Gly Gly Trp Ala
355 360 365

Phe Glu Phe Ala Asn Asp Asn Tyr Pro Asp Thr Asp Asp Thr Ala Glu
370 375 380

Val Val Leu Ala Leu Arg Arg Val Arg Leu Glu Asp Ala Asp Gln Gln
385 390 395 400

Ala Leu Glu Ala Ala Val Arg Arg Ala Thr Thr Trp Val Ile Gly Met
405 410 415

Gln Ser Thr Asp Gly Gly Trp Gly Ala Phe Asp Ala Asp Asn Thr Arg
420 425 430

Glu Leu Val Leu Arg Leu Pro Phe Cys Asp Phe Gly Ala Val Ile Asp
435 440 445

Pro Pro Ser Ala Asp Val Thr Ala His Ile Val Glu Met Leu Ala Ala
450 455 460

Leu Gly Met Arg Asp His Pro Ala Thr Val Ala Gly Val Arg Trp Leu
465 470 475 480

Leu Ala His Gln Glu Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Ala
485 490 495

Asn His Ile Tyr Gly Thr Gly Ala Val Val Pro Ala Leu Ile Ala Ala
500 505 510

Gly Val Ser Pro Asp Thr Pro Pro Ile Arg Arg Ala Ile Arg Trp Leu
515 520 525

Glu Glu His Gln Asn Pro Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser
530 535 540

Tyr Thr Asp Pro Ala Leu Trp Val Gly Arg Gly Val Ser Thr Ala Ser
545 550 555 560

Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala Ala Gly Glu Glu Ala
565 570 575

Ser Pro Ala Val Asp Arg Gly Val Arg Trp Leu Val Thr Thr Gln Gln
580 585 590

Pro Asp Gly Gly Trp Asp Glu Pro His Tyr Thr Gly Thr Gly Phe Pro
595 600 605

Gly Asp Phe Tyr Ile Asn Tyr His Leu Tyr Arg Leu Val Phe Pro Ile
610 615 620

Ser Ala Leu Gly Arg Tyr Val Asn Arg
625 630


<210> 11
<211> 695
<212> PRT
<213> Adiantum capillus-veneris

<400> 11
Met Leu Pro Tyr Asn Gln Asp His His Phe Gly Lys Val Ala Glu Asn
1 5 10 15

Ala Thr Met Pro Pro Thr Leu Asp Glu Ala Ile Glu Arg Ser Gln Asp
20 25 30

Phe Leu Leu Ser Leu Gln Tyr Pro Glu Gly Tyr Trp Trp Ala Glu Leu
35 40 45

Glu Ala Asn Val Thr Leu Thr Ala Gln Thr Ile Met Leu Tyr Lys Ile
50 55 60

Leu Gly Ile Asp His Lys Tyr Pro Ile His Lys Met Lys Thr Tyr Ile
65 70 75 80

Leu Arg Thr Gln Arg Ala His Gly Gly Trp Glu Ile Phe Tyr Gly Asp
85 90 95

Gly Gly Cys Leu Ser Thr Thr Ile Gly Ala Tyr Met Ala Leu Arg Ile
100 105 110

Leu Gly Val Pro Lys Thr Asp Pro Val Leu Gln Lys Ala Leu Lys Leu
115 120 125

Ile His Ser Lys Gly Gly Val Thr Lys Ser Arg Met Phe Thr Lys Ile
130 135 140

Cys Leu Ala Leu Leu Gly Cys Tyr Asp Trp Lys Gly Ile Pro Ser Leu
145 150 155 160

Pro Pro Trp Leu Val Leu Leu Pro Ser Trp Phe Pro Phe Ser Leu Tyr
165 170 175

Asp Thr Ala Ser Trp Val Arg Gly Cys Val Val Pro Leu Thr Ile Ile
180 185 190

Phe Asp Lys Lys Pro Val Tyr Lys Leu Asn Pro Leu Leu Cys Leu Asp
195 200 205

Glu Leu Tyr Ser Glu Gly Lys Gly Lys Ala Arg Val His Leu Ser Phe
210 215 220

Ile Pro Gly Asp Trp Thr Ser Asn Phe Phe Val Gly Leu Asp His Val
225 230 235 240

Phe Lys Tyr Met Glu Asn Leu Gly Val Val Pro Phe Arg Gln Trp Gly
245 250 255

Ile Lys Glu Ala Glu Arg Trp Thr Leu Glu Arg His Glu Asp Ser Gly
260 265 270

Asp Phe His Gly Ile Tyr Pro Pro Met Phe Tyr Ser Ile Val Ser Tyr
275 280 285

Ser Leu Leu Gly Tyr Glu Ile Thr Asp Pro Val Val His Arg Ala Leu
290 295 300

Glu Ser Met Arg Gly Phe Thr Val Glu Arg Glu Asp Glu Cys Val Val
305 310 315 320

Gln Ser Cys Ile Ser Pro Met Trp Asp Thr Ala Phe Val Ile Arg Ser
325 330 335

Leu Ala Glu Ser Gly Leu Gln Pro Asp His Pro Ala Leu Gln Lys Ala
340 345 350

Gly Glu Trp Leu Leu Gln Lys Gln Ala Thr Gln His Gly Asn Trp Phe
355 360 365

Tyr Lys Lys Arg Thr Gly Arg Ala Gly Gly Trp Ala Phe Gln Phe Phe
370 375 380

Asn Arg Trp Tyr Pro Asp Val Asp Asp Ser Ala Ala Val Ser Met Ala
385 390 395 400

Leu Asn Ala Ile Lys Leu Gln Asp Asp Asp Val Lys Lys Gly Ala Ile
405 410 415

Lys Arg Cys Ala Glu Trp Ile Ser Val Met Gln Cys Lys Asp Gly Gly
420 425 430

Trp Ala Ala Tyr Asp Cys Asp Asn Asp Arg Glu Trp Leu Asn Cys Thr
435 440 445

Pro Phe Gly Asp Leu Lys Ala Met Ile Asp Pro Asn Thr Val Asp Val
450 455 460

Thr Ala Arg Val Leu Glu Met Val Gly Arg Val Lys Glu Ala Gly Asp
465 470 475 480

Ala Ser Ala Ile Leu Pro Pro Arg Ala Ile Ala Arg Gly Leu Ala Tyr
485 490 495

Leu Arg Arg Glu Gln Glu Thr Glu Gly Cys Trp Tyr Gly Arg Trp Gly
500 505 510

Val Asn Tyr Ile Tyr Gly Thr Ser Gly Ala Leu Met Ala Leu Ala Leu
515 520 525

Val Ala Pro Ser Thr His Lys Glu Glu Ile Glu Arg Gly Ala Arg Trp
530 535 540

Leu Val Glu Val Gln Asn Lys Arg Gly Thr Lys Gly Ala Asn Gly Tyr
545 550 555 560

Ser His Thr Asn Gly Ala Arg Glu Gly Gly Val Ala Met Asn Gly Asn
565 570 575

Cys Lys Asn Met Gly Ala Pro Glu Asp Gly Gly Trp Gly Glu Thr Cys
580 585 590

Phe Ser Tyr Asn Asp Ile Thr Leu Lys Gly Arg Asn Glu Val Ser Thr
595 600 605

Val Ser Gln Thr Ala Trp Ala Leu Gln Gly Leu Leu Ala Ala Gly Asp
610 615 620

Ala Leu Gly Lys Tyr Glu Val Glu Ser Ile Glu His Gly Val Gln Tyr
625 630 635 640

Leu Leu Ser Thr Gln Arg Lys Asp Gly Ser Trp Cys Glu Lys His Phe
645 650 655

Thr Gly Gly Gly Phe Pro Arg Phe Phe Tyr Ile Arg Tyr His Leu Tyr
660 665 670

Ala Gly His Phe Pro Leu Ser Ala Leu Ala Arg Tyr Arg Asp Arg Val
675 680 685

Arg Ala Gly Lys Met Ala Lys
690 695


<210> 12
<211> 740
<212> PRT
<213> Ajellomyces capsulatus

<400> 12
Met Met Tyr Asn Asn Gln Trp Tyr Phe Asn Gln Phe Asn Asp Ile Phe
1 5 10 15

Cys Phe Pro Glu Gln Gln Lys Glu Tyr Phe Pro Pro Thr Gly Thr Asn
20 25 30

Ile Ser Leu Asn Leu Lys Lys Arg Pro Asp Arg Gln Leu Leu Ala His
35 40 45

Gly Ala Ser Asp Leu Asn Gly Pro Phe His Leu Ser Gln His Asn Ala
50 55 60

Phe Ser Ala Met Leu Leu Ala Glu Val Gln Lys Val Leu Arg Leu Ala
65 70 75 80

Val Gly His Ser Leu Asp Leu Gln Arg Thr Asp Gly Ala Trp Cys Gly
85 90 95

Glu Val His Ser Asn Ala Thr Phe Thr Ala Gln Tyr Val Phe Leu Gln
100 105 110

Gln Gln Leu Gly Leu Pro Leu Asp Pro Thr Glu Ile Glu Gly Leu Ser
115 120 125

Arg Trp Leu Phe Ser Gln Gln Asn Glu Asp Gly Ser Trp Gly Leu Gly
130 135 140

Pro Gly Leu Gly Gly Asp Val Ser Thr Thr Thr Glu Thr Tyr Leu Ala
145 150 155 160

Leu Lys Ile Leu Gly Val Ser Pro Glu Asp Pro Arg Met Ala Ala Ala
165 170 175

Arg Ser Ser Ile Ile Lys Ala Gly Ser Leu Pro Ala Thr Arg Met Phe
180 185 190

Thr Arg Val Phe Leu Ala Ser Phe Gly Leu Ile Pro Trp Ser Ala Val
195 200 205

Pro Pro Leu Pro Ala Glu Leu Ile Leu Leu Pro Thr Leu Phe Pro Val
210 215 220

Asn Ile Tyr Asn Leu Ser Ser Trp Ala Arg Ala Thr Cys Val Pro Leu
225 230 235 240

Leu Leu Ile Arg His His Glu Pro Leu His Ser Leu Pro Asn Gly Arg
245 250 255

His Ala Glu Asn Asp Phe Leu Asp Glu Leu Trp Thr Lys Asp Ile Pro
260 265 270

Arg Asp Phe Cys Tyr Thr Thr Pro Leu Ser Arg Met Trp Arg Leu Gly
275 280 285

Asp Tyr Ala Gly Ile Phe Phe Thr Ser Ala Asp His Gly Leu Arg Phe
290 295 300

Leu Gly Gln Tyr Phe Asn Ser Pro Leu Arg Asn Leu Ser Arg Arg Lys
305 310 315 320

Ile Ile Asn Trp Ile Leu Asp His Gln Glu Gln Ser Gly Glu Trp Ala
325 330 335

Gly Tyr Trp Pro Pro Gln His Asn Asn Ile Trp Ala Leu Ser Leu Glu
340 345 350

Gly Tyr Ser Leu Asp His Pro Val Leu Arg Arg Gly Ile Ala Ala Val
355 360 365

Lys Ser Phe Val Leu His Asp Val Thr Gly Met Arg Ala Gln Val Thr
370 375 380

Val Ser Gln Val Trp Asp Thr Ala Leu Met Ser Ile Ala Leu Ser Asp
385 390 395 400

Ser Ala Pro Ser Thr Gly Ile Ile Ser Pro Thr Gln Ala Ile Asp Trp
405 410 415

Leu Met His His Glu Val Ala Ser His Arg Gly Asp Trp Arg Val Leu
420 425 430

Arg Pro Lys Leu Ala Thr Gly Gly Phe Cys Phe Glu Glu Phe Asn Thr
435 440 445

Leu Tyr Pro Asp Val Asp Asp Thr Ala Ala Val Ile Met Ala Leu Ile
450 455 460

Lys Ser Asn Pro Ala His Leu Ile Ser Gly Cys Val Arg Arg Ala Ala
465 470 475 480

Gln Trp Ile Leu Gly Met Gln Asn Arg Asp Gly Gly Trp Gly Ala Phe
485 490 495

Asp Trp Asn Asn Asp Lys Phe Phe Leu Asn Lys Ile Pro Phe Ser Asp
500 505 510

Met Asp Ser Leu Cys Asp Pro Ser Thr Pro Asp Val Thr Gly Arg Ile
515 520 525

Ile Glu Cys Phe Gly Met Met Met Ala Gly Arg His Gly Tyr Ser Leu
530 535 540

Asp Gly Pro Leu Glu Ser Arg Leu Arg Ala Ser Ser Gln Leu Ala Ile
545 550 555 560

Ala Tyr Leu Leu Gly Cys Gln Glu Asn Asn Gly Ser Trp Trp Gly Arg
565 570 575

Trp Gly Val Asn Tyr Leu Tyr Gly Thr Ser Asn Val Leu Cys Gly Leu
580 585 590

Ala Tyr Tyr Tyr Asp Arg Ser Gly Leu Ser Lys Gly Asp Gly Lys Ser
595 600 605

Asn Ser His Ile Val Ser Ala Val Asp Arg Ala Ser Glu Trp Leu Lys
610 615 620

Ala Arg Gln His Ser Asn Gly Gly Trp Gly Glu Gly Pro Glu Ser Tyr
625 630 635 640

Asp Ser Ala Gln Leu Ala Gly Cys Gly Gln Pro Thr Ala Ser Gln Ser
645 650 655

Ala Trp Val Thr Met Ala Leu Leu Asn Tyr Leu Ser Pro Thr Asp Glu
660 665 670

Val Ile Gln Arg Gly Ile Ser Tyr Leu Val Arg Ser Gln Val Lys Tyr
675 680 685

Gly Asp Glu Ser Arg Ala Thr Trp Pro Leu Glu Arg Tyr Thr Ala Thr
690 695 700

Gly Phe Pro Gly His Leu Tyr Met Glu Tyr Asp Tyr Tyr Arg His Tyr
705 710 715 720

Phe Pro Ile Met Ala Leu Gly Arg Tyr Val Asn Lys Leu Ser Glu Ser
725 730 735

His Lys Leu Leu
740


<210> 13
<211> 648
<212> PRT
<213> Ajellomyces capsulatus

<400> 13
Met Ala Gln Met Ala Ser Ser Leu Gly Ser Pro Arg Leu Leu Leu Arg
1 5 10 15

Met Gly Arg Glu Ala Ala Gln Gln Gln His Leu Ala Ser Gly Thr Glu
20 25 30

Val Gln Lys Ala Leu Arg Leu Ala Val Gly His Ser Leu Asp Leu Gln
35 40 45

Arg Thr Asp Gly Ala Trp Cys Gly Glu Val His Ser Asn Ala Thr Phe
50 55 60

Thr Ala Gln Tyr Val Phe Leu Gln Gln Gln Ile Gly Leu Pro Leu Asp
65 70 75 80

Pro Thr Glu Ile Glu Gly Leu Ser Arg Trp Leu Phe Ser Gln Gln Asn
85 90 95

Glu Asp Gly Ser Trp Gly Leu Gly Pro Gly Leu Gly Gly Asp Val Ser
100 105 110

Thr Thr Thr Glu Thr Tyr Leu Ala Leu Lys Ile Leu Gly Val Ser Pro
115 120 125

Glu Asp Pro Arg Met Ala Ala Ala Arg Thr Ser Ile Ile Lys Ala Gly
130 135 140

Ser Leu Pro Ala Thr Arg Met Phe Thr Arg Val Phe Leu Ala Ser Phe
145 150 155 160

Gly Leu Ile Pro Trp Ser Ala Val Pro Pro Leu Pro Ala Glu Leu Ile
165 170 175

Leu Leu Pro Thr Leu Phe Pro Val Asn Ile Tyr Asn Leu Ser Ser Trp
180 185 190

Ala Arg Ala Thr Cys Val Pro Leu Leu Leu Ile Arg His His Glu Pro
195 200 205

Leu His Ser Leu Pro Asn Gly Arg His Ala Glu Asn Asp Phe Leu Asp
210 215 220

Glu Leu Trp Thr Lys Asp Ile Pro Arg Asp Phe Cys Tyr Thr Thr Pro
225 230 235 240

Leu Ser Arg Met Trp Arg Leu Gly Asp Tyr Ala Gly Ile Phe Phe Thr
245 250 255

Ser Ala Asp His Gly Phe Arg Phe Leu Gly Gln Tyr Phe Asn Ser Pro
260 265 270

Leu Arg Asn Leu Ser Arg Arg Lys Ile Ile Asn Trp Ile Leu Asp His
275 280 285

Gln Glu Gln Ser Gly Glu Trp Ala Gly Tyr Trp Pro Pro Gln His Asn
290 295 300

Asn Ile Trp Ala Leu Ser Leu Glu Gly Tyr Ser Leu Asp His Pro Val
305 310 315 320

Leu Arg Arg Gly Ile Ala Ala Val Lys Ser Phe Val Leu His Asp Ala
325 330 335

Thr Gly Met Arg Ala Gln Val Thr Val Ser Gln Val Trp Asp Thr Ala
340 345 350

Leu Met Ser Ile Ala Leu Ser Asp Ser Ala Pro Ser Thr Gly Ile Ile
355 360 365

Ser Pro Thr Gln Ala Ile Asp Trp Leu Met His His Glu Val Ala Ser
370 375 380

His Arg Gly Asp Trp Arg Val Leu Arg Pro Lys Leu Ala Thr Gly Gly
385 390 395 400

Phe Cys Phe Glu Glu Phe Asn Thr Leu Tyr Pro Asp Val Asp Asp Thr
405 410 415

Ala Ala Val Ile Met Ala Leu Ile Lys Ser Asn Pro Ala His Leu Ile
420 425 430

Ser Gly Cys Val Arg Gln Cys Phe Gly Met Met Met Ala Gly Arg His
435 440 445

Gly Tyr Ser Leu Asp Cys Gln Leu Glu Thr Arg Leu Arg Ala Ser Ser
450 455 460

Gln Leu Ala Ile Ala Tyr Leu Leu Gly Cys Gln Glu Asn Asn Gly Ser
465 470 475 480

Trp Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Ser Asn Val
485 490 495

Leu Cys Gly Leu Ala Tyr Tyr Tyr Asp Arg Ser Ser Leu Ser Lys Gly
500 505 510

Asp Gly Lys Ser Asn Ser Asn Ile Val Ser Ala Val Asp Arg Ala Ser
515 520 525

Glu Trp Leu Lys Ala Arg Gln His Ser Asn Gly Gly Trp Gly Glu Gly
530 535 540

Leu Glu Ser Tyr Asp Asn Ala Gln Leu Ala Gly Cys Gly Gln Pro Thr
545 550 555 560

Ala Ser Gln Ser Ala Trp Val Thr Met Ala Leu Leu Asn Tyr Leu Ser
565 570 575

Pro Thr Asp Glu Val Ile Gln Arg Gly Val Ser Tyr Leu Val Arg Asn
580 585 590

Gln Val Lys Tyr Gly Asp Glu Ser Arg Ala Thr Trp Pro Leu Glu Arg
595 600 605

Tyr Thr Ala Thr Gly Phe Pro Gly His Leu Tyr Met Glu Tyr Asp Tyr
610 615 620

Tyr Arg His Tyr Phe Pro Ile Met Ala Leu Gly Arg Tyr Val Asn Lys
625 630 635 640

Leu Ser Gly Ser His Lys Leu Leu
645


<210> 14
<211> 673
<212> PRT
<213> Ajellomyces capsulatus

<400> 14
Met Leu Leu Ala Glu Val Gln Lys Ala Leu Arg Leu Ala Val Gly His
1 5 10 15

Ser Leu Asp Leu Gln Arg Ala Asp Gly Ala Trp Cys Gly Glu Val His
20 25 30

Ser Asn Ala Thr Phe Thr Ser Gln Tyr Val Phe Leu Gln Gln Gln Ile
35 40 45

Gly Leu Pro Leu Asp Pro Thr Glu Ile Glu Gly Leu Ser Arg Trp Leu
50 55 60

Phe Ser Gln Gln Asn Glu Asp Gly Ser Trp Gly Leu Gly Pro Gly Leu
65 70 75 80

Gly Gly Asp Val Ser Thr Thr Thr Glu Thr Tyr Leu Ala Leu Lys Ile
85 90 95

Leu Gly Val Ser Pro Glu Asp Pro Arg Met Ala Ala Ala Arg Thr Ser
100 105 110

Ile Ile Lys Ala Gly Ser Leu Pro Ala Thr Arg Met Phe Thr Arg Val
115 120 125

Phe Leu Ala Ser Phe Gly Leu Ile Pro Trp Ser Ala Val Pro Pro Leu
130 135 140

Pro Ala Glu Leu Ile Leu Leu Pro Thr Leu Phe Pro Val Asn Ile Tyr
145 150 155 160

Asn Leu Ser Ser Trp Ala Arg Ala Thr Cys Val Pro Leu Leu Leu Ile
165 170 175

Arg His His Glu Pro Leu His Ser Leu Pro Asn Gly Arg His Ala Glu
180 185 190

Asn Asp Phe Leu Asp Glu Leu Trp Thr Lys Asp Ile Pro Arg Asp Phe
195 200 205

Cys Tyr Thr Thr Pro Leu Ser Arg Met Trp Arg Leu Gly Asp Tyr Ala
210 215 220

Gly Ile Phe Phe Thr Ser Ala Asp His Gly Leu Arg Phe Leu Gly Gln
225 230 235 240

Tyr Phe His Ser Pro Leu Arg Asn Leu Ser Arg Arg Lys Ile Ile Asn
245 250 255

Trp Ile Leu Asp His Gln Glu Gln Ser Gly Glu Trp Ala Gly Tyr Trp
260 265 270

Pro Pro Gln His Asn Asn Ile Trp Ala Leu Ser Leu Glu Gly Tyr Ser
275 280 285

Leu Asp His Pro Val Leu Arg Arg Gly Ile Ala Ala Val Lys Ser Phe
290 295 300

Val Leu His Asp Ala Thr Gly Met Arg Ala Gln Val Thr Val Ser Gln
305 310 315 320

Val Trp Asp Thr Ala Leu Met Ser Ile Ala Leu Ser Asp Ser Ala Pro
325 330 335

Ser Thr Gly Ile Ile Ser Pro Thr Gln Ala Ile Asp Trp Leu Met His
340 345 350

His Glu Val Ala Ser His Arg Gly Asp Trp Arg Val Leu Arg Pro Lys
355 360 365

Leu Ala Thr Gly Gly Phe Cys Phe Glu Glu Phe Asn Thr Leu Tyr Pro
370 375 380

Asp Val Asp Asp Thr Ala Ala Val Ile Met Ala Leu Ile Lys Ser Asn
385 390 395 400

Pro Ala His Leu Ile Ser Gly Cys Val Arg Arg Ala Ala Gln Trp Ile
405 410 415

Leu Gly Met Gln Asn Arg Asp Gly Gly Trp Gly Ala Phe Asp Trp Asn
420 425 430

Asn Asp Lys Phe Phe Leu Asn Lys Ile Pro Phe Ser Asp Met Asp Ser
435 440 445

Leu Cys Asp Pro Ser Thr Pro Asp Val Thr Gly Arg Ile Ile Glu Cys
450 455 460

Phe Gly Met Met Met Ala Gly Arg His Gly Tyr Ser Leu Asp Cys Gln
465 470 475 480

Leu Glu Asn Arg Leu Arg Ala Ser Ser Gln Leu Ala Ile Ala Tyr Leu
485 490 495

Leu Gly Cys Gln Glu Asn Asn Gly Ser Trp Trp Gly Arg Trp Gly Val
500 505 510

Asn Tyr Leu Tyr Gly Thr Ser Asn Val Leu Cys Gly Leu Ala Tyr Tyr
515 520 525

Tyr Asp Arg Ser Ser Leu Ser Lys Gly Asp Val Lys Ser Asn Ser Asn
530 535 540

Ile Val Ser Ala Val Asp Arg Ala Ser Glu Trp Leu Lys Ala Arg Gln
545 550 555 560

His Ser Asn Gly Gly Trp Gly Glu Gly Pro Glu Ser Tyr Asp Asn Ala
565 570 575

Gln Leu Ala Gly Cys Gly Gln Pro Thr Ala Ser Gln Ser Ala Trp Val
580 585 590

Thr Met Ala Leu Leu Asn Tyr Leu Ser Pro Thr Asp Glu Val Ile Gln
595 600 605

Arg Gly Val Ser Tyr Leu Val Arg Asn Gln Val Lys Tyr Gly Asp Glu
610 615 620

Ser Arg Ala Thr Trp Leu Leu Glu Arg Tyr Thr Ala Thr Gly Phe Pro
625 630 635 640

Gly His Leu Tyr Met Glu Tyr Asp Tyr Tyr Arg His Tyr Phe Pro Ile
645 650 655

Met Ala Leu Gly Arg Tyr Val Asn Lys Leu Ser Gly Ser His Lys Leu
660 665 670

Leu


<210> 15
<211> 631
<212> PRT
<213> Alicyclobacillus acidocaldarius

<400> 15
Met Ala Glu Gln Leu Val Glu Ala Pro Ala Tyr Ala Arg Thr Leu Asp
1 5 10 15

Arg Ala Val Glu Tyr Leu Leu Ser Cys Gln Lys Asp Glu Gly Tyr Trp
20 25 30

Trp Gly Pro Leu Leu Ser Asn Val Thr Met Glu Ala Glu Tyr Val Leu
35 40 45

Leu Cys His Ile Leu Asp Arg Val Asp Arg Asp Arg Met Glu Lys Ile
50 55 60

Arg Arg Tyr Leu Leu His Glu Gln Arg Glu Asp Gly Thr Trp Ala Leu
65 70 75 80

Tyr Pro Gly Gly Pro Pro Asp Leu Asp Thr Thr Ile Glu Ala Tyr Val
85 90 95

Ala Leu Lys Tyr Ile Gly Met Ser Arg Asp Glu Glu Pro Met Gln Lys
100 105 110

Ala Leu Arg Phe Ile Gln Ser Gln Gly Gly Ile Glu Ser Ser Arg Val
115 120 125

Phe Thr Arg Met Trp Leu Ala Leu Val Gly Glu Tyr Pro Trp Glu Lys
130 135 140

Val Pro Met Val Pro Pro Glu Ile Met Phe Leu Gly Lys Arg Met Pro
145 150 155 160

Leu Asn Ile Tyr Glu Phe Gly Ser Trp Ala Arg Ala Thr Val Val Ala
165 170 175

Ile Ser Ile Val Met Ser Arg Gln Pro Val Phe Pro Leu Pro Glu Arg
180 185 190

Ala Arg Val Pro Glu Leu Tyr Asp Thr Asp Val Pro Pro Arg Arg Arg
195 200 205

Gly Ala Lys Gly Gly Gly Gly Arg Ile Phe Asp Ala Leu Asp Arg Ala
210 215 220

Leu His Gly Tyr Gln Lys Leu Ser Val His Pro Phe Arg Arg Ala Ala
225 230 235 240

Glu Ile Arg Ala Leu Asp Trp Leu Leu Glu Arg Gln Ala Gly Asp Gly
245 250 255

Ser Trp Gly Gly Ile Gln Pro Pro Trp Phe Tyr Thr Leu Ile Ala Leu
260 265 270

Lys Ile Leu Asp Met Thr Gln His Pro Ala Phe Ile Lys Gly Trp Glu
275 280 285

Gly Leu Glu Leu Tyr Gly Val Asp Leu Asp Tyr Gly Gly Trp Met Phe
290 295 300

Gln Ala Ser Ile Ser Pro Val Trp Asp Thr Gly Leu Ala Val Leu Ala
305 310 315 320

Leu Arg Ala Ala Gly Leu Pro Ala Asp His Asp Arg Leu Val Lys Ala
325 330 335

Gly Glu Trp Leu Leu Asp Arg Gln Ile Thr Val Pro Gly Asp Trp Ala
340 345 350

Val Lys Arg Pro Asn Leu Lys Pro Gly Gly Phe Ala Phe Gln Phe Asp
355 360 365

Asn Val Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Trp Ala
370 375 380

Leu Asn Ser Leu Arg Leu Pro Asp Glu Arg Arg Arg Arg Asp Val Met
385 390 395 400

Thr Lys Gly Phe Arg Trp Ile Val Gly Met Gln Ser Ser Asn Gly Gly
405 410 415

Trp Gly Ala Tyr Asp Val Asp Asn Thr Ser Asp Leu Pro Asn His Ile
420 425 430

Pro Phe Cys Asp Phe Gly Glu Val Thr Asp Pro Pro Ser Glu Asp Val
435 440 445

Thr Ala His Val Leu Glu Cys Phe Gly Ser Phe Gly Tyr Asp Asp Ala
450 455 460

Trp Lys Val Ile Arg Arg Ala Val Glu Tyr Leu Lys Arg Glu Gln Arg
465 470 475 480

Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly
485 490 495

Thr Gly Ala Val Val Pro Ala Leu Lys Ala Val Gly Ile Asp Val Arg
500 505 510

Glu Pro Phe Ile Gln Lys Ala Leu Asp Trp Val Glu Gln His Gln Asn
515 520 525

Pro Asp Gly Gly Trp Gly Glu Asp Cys Arg Ser Tyr Glu Asp Pro Ala
530 535 540

Tyr Ala Gly Lys Gly Ala Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu
545 550 555 560

Met Ala Leu Ile Ala Gly Gly Arg Ala Glu Ser Asp Ser Val Arg Arg
565 570 575

Gly Val Gln Tyr Leu Val Glu Thr Gln Arg Pro Asp Gly Gly Trp Asp
580 585 590

Glu Pro Tyr Tyr Thr Gly Thr Gly Phe Pro Gly Asp Phe Tyr Leu Gly
595 600 605

Tyr Thr Met Tyr Arg His Val Phe Pro Thr Leu Ala Leu Gly Arg Tyr
610 615 620

Lys Gln Ala Ile Glu Arg Arg
625 630


<210> 16
<211> 631
<212> PRT
<213> Alicyclobacillus acidocaldarius

<400> 16
Met Ala Glu Gln Leu Val Glu Ala Pro Ala Tyr Ala Arg Thr Leu Asp
1 5 10 15

Arg Ala Val Glu Tyr Leu Leu Ser Cys Gln Lys Asp Glu Gly Tyr Trp
20 25 30

Trp Gly Pro Leu Leu Ser Asn Val Thr Met Glu Ala Glu Tyr Val Leu
35 40 45

Leu Cys His Ile Leu Asp Arg Val Asp Arg Asp Arg Met Glu Lys Ile
50 55 60

Arg Arg Tyr Leu Leu His Glu Gln Arg Glu Asp Gly Thr Trp Ala Leu
65 70 75 80

Tyr Pro Gly Gly Pro Pro Asp Leu Asp Thr Thr Ile Glu Ala Tyr Val
85 90 95

Ala Leu Lys Tyr Ile Gly Met Ser Arg Asp Glu Glu Pro Met Gln Lys
100 105 110

Ala Leu Arg Phe Ile Gln Ser Gln Gly Gly Ile Glu Ser Ser Arg Val
115 120 125

Phe Thr Arg Met Trp Leu Ala Leu Val Gly Glu Tyr Pro Trp Glu Lys
130 135 140

Val Pro Met Val Pro Pro Glu Ile Met Phe Leu Gly Lys Arg Met Pro
145 150 155 160

Leu Asn Ile Tyr Glu Phe Gly Ser Trp Ala Arg Ala Thr Val Val Ala
165 170 175

Leu Ser Ile Val Met Ser Arg Gln Pro Val Phe Pro Leu Pro Glu Arg
180 185 190

Ala Arg Val Pro Glu Leu Tyr Glu Thr Asp Val Pro Pro Arg Arg Arg
195 200 205

Gly Ala Lys Gly Gly Gly Gly Trp Ile Phe Asp Ala Leu Asp Arg Ala
210 215 220

Leu His Gly Tyr Gln Lys Leu Ser Val His Pro Phe Arg Arg Ala Ala
225 230 235 240

Glu Ile Arg Ala Leu Asp Trp Leu Leu Glu Arg Gln Ala Gly Asp Gly
245 250 255

Ser Trp Gly Gly Ile Gln Pro Pro Trp Phe Tyr Ala Leu Ile Ala Leu
260 265 270

Lys Ile Leu Asp Met Thr Gln His Pro Ala Phe Ile Lys Gly Trp Glu
275 280 285

Gly Leu Glu Leu Tyr Gly Val Glu Leu Asp Tyr Gly Gly Trp Met Phe
290 295 300

Gln Ala Ser Ile Ser Pro Val Trp Asp Thr Gly Leu Ala Val Leu Ala
305 310 315 320

Leu Arg Ala Ala Gly Leu Pro Ala Asp His Asp Arg Leu Val Lys Ala
325 330 335

Gly Glu Trp Leu Leu Asp Arg Gln Ile Thr Val Pro Gly Asp Trp Ala
340 345 350

Val Lys Arg Pro Asn Leu Lys Pro Gly Gly Phe Ala Phe Gln Phe Asp
355 360 365

Asn Val Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Trp Ala
370 375 380

Leu Asn Thr Leu Arg Leu Pro Asp Glu Arg Arg Arg Arg Asp Ala Met
385 390 395 400

Thr Lys Gly Phe Arg Trp Ile Val Gly Met Gln Ser Ser Asn Gly Gly
405 410 415

Trp Gly Ala Tyr Asp Val Asp Asn Thr Ser Asp Leu Pro Asn His Ile
420 425 430

Pro Phe Cys Asp Phe Gly Glu Val Thr Asp Pro Pro Ser Glu Asp Val
435 440 445

Thr Ala His Val Leu Glu Cys Phe Gly Ser Phe Gly Tyr Asp Asp Ala
450 455 460

Trp Lys Val Ile Arg Arg Ala Val Glu Tyr Leu Lys Arg Glu Gln Lys
465 470 475 480

Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly
485 490 495

Thr Gly Ala Val Val Ser Ala Leu Lys Ala Val Gly Ile Asp Thr Arg
500 505 510

Glu Pro Tyr Ile Gln Lys Ala Leu Asp Trp Val Glu Gln His Gln Asn
515 520 525

Pro Asp Gly Gly Trp Gly Glu Asp Cys Arg Ser Tyr Glu Asp Pro Ala
530 535 540

Tyr Ala Gly Lys Gly Ala Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu
545 550 555 560

Met Ala Leu Ile Ala Gly Gly Arg Ala Glu Ser Glu Ala Ala Arg Arg
565 570 575

Gly Val Gln Tyr Leu Val Glu Thr Gln Arg Pro Asp Gly Gly Trp Asp
580 585 590

Glu Pro Tyr Tyr Thr Gly Thr Gly Phe Pro Gly Asp Phe Tyr Leu Gly
595 600 605

Tyr Thr Met Tyr Arg His Val Phe Pro Thr Leu Ala Leu Gly Arg Tyr
610 615 620

Lys Gln Ala Ile Glu Arg Arg
625 630


<210> 17
<211> 227
<212> PRT
<213> Alicyclobacillus acidocaldarius

<400> 17
Gln Ala Ser Ile Ser Pro Val Trp Asp Thr Gly Leu Ala Val Leu Ala
1 5 10 15

Leu Arg Ala Ala Gly Leu Pro Ala Asp His Asp Arg Leu Val Lys Ala
20 25 30

Gly Glu Trp Leu Leu Asp Arg Gln Ile Thr Val Pro Gly Asp Trp Val
35 40 45

Val Lys Arg Pro Asn Leu Asn Pro Gly Gly Phe Ala Leu Gln Phe Asp
50 55 60

Asn Val Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ile Trp Ala
65 70 75 80

Leu Asn Thr Leu Arg Leu Pro Asp Glu Arg Arg Arg Arg Asp Ala Met
85 90 95

Thr Lys Gly Phe Arg Trp Ile Val Gly Met Gln Ser Ser Asn Gly Gly
100 105 110

Trp Gly Ala Tyr Asp Val Asp Asn Thr Ser Asp Leu Pro Asn His Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Val Thr Asp Pro Pro Ser Glu Asp Val
130 135 140

Thr Ala His Val Leu Glu Cys Phe Gly Ser Phe Gly Tyr Asp Asp Ala
145 150 155 160

Trp Lys Val Ile Gln Arg Ala Val Ala Tyr Leu Lys Arg Glu Gln Lys
165 170 175

Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Gly Ala Val Val Ser Ala Leu Lys Ala Val Gly Ile Asp Met Arg
195 200 205

Glu Pro Tyr Ile Gln Lys Ala Leu Asp Trp Val Glu Gln His Gln Asn
210 215 220

Pro Asp Gly
225


<210> 18
<211> 634
<212> PRT
<213> Alicyclobacillus acidoterrestris

<400> 18
Met Thr Lys Gln Leu Leu Asp Thr Pro Met Val Gln Ala Thr Leu Glu
1 5 10 15

Ala Gly Val Ala His Leu Leu Arg Arg Gln Ala Pro Asp Gly Tyr Trp
20 25 30

Trp Ala Pro Leu Leu Ser Asn Val Cys Met Glu Ala Glu Tyr Val Leu
35 40 45

Leu Cys His Cys Leu Gly Lys Lys Asn Pro Glu Arg Glu Ala Gln Ile
50 55 60

Arg Lys Tyr Ile Ile Ser Gln Arg Arg Glu Asp Gly Thr Trp Ser Ile
65 70 75 80

Tyr Pro Gly Gly Pro Ser Asp Leu Asn Ala Thr Val Glu Ala Tyr Val
85 90 95

Ala Leu Lys Tyr Leu Gly Glu Pro Ala Ser Asp Pro Gln Met Val Gln
100 105 110

Ala Lys Glu Phe Ile Gln Asn Glu Gly Gly Ile Glu Ser Thr Arg Val
115 120 125

Phe Thr Arg Leu Trp Leu Ala Met Val Gly Gln Tyr Pro Trp Asp Lys
130 135 140

Leu Pro Val Ile Pro Pro Glu Ile Met His Leu Pro Lys Ser Val Pro
145 150 155 160

Leu Asn Ile Tyr Asp Phe Ala Ser Trp Ala Arg Ala Thr Ile Val Thr
165 170 175

Leu Ser Tyr Arg His Glu Ser Pro Thr Cys Asp Ala Thr Ser Gly Leu
180 185 190

Cys Lys Gly Ser Gly Ile Val Arg Gly Glu Gly Pro Pro Lys Arg Arg
195 200 205

Ser Ala Lys Gly Gly Asp Ser Gly Phe Phe Val Ala Leu Asp Lys Phe
210 215 220

Leu Lys Ala Tyr Asn Lys Trp Pro Ile Gln Pro Gly Arg Lys Ser Gly
225 230 235 240

Glu Gln Lys Ala Leu Glu Trp Ile Leu Ala His Gln Glu Ala Asp Gly
245 250 255

Cys Trp Gly Gly Ile Gln Pro Pro Trp Phe Tyr Ala Leu Leu Ala Leu
260 265 270

Lys Cys Leu Asn Met Thr Asp His Pro Ala Phe Val Lys Gly Phe Glu
275 280 285

Gly Leu Glu Ala Tyr Gly Val His Thr Ser Asp Gly Gly Trp Met Phe
290 295 300

Gln Ala Ser Ile Ser Pro Ile Trp Asp Thr Gly Leu Thr Val Leu Ala
305 310 315 320

Leu Arg Ser Ala Gly Leu Pro Pro Asp His Pro Ala Leu Ile Lys Ala
325 330 335

Gly Glu Trp Leu Val Ser Lys Gln Ile Leu Lys Asp Gly Asp Trp Lys
340 345 350

Val Arg Arg Arg Lys Ala Lys Pro Gly Gly Trp Ala Phe Glu Phe His
355 360 365

Cys Glu Asn Tyr Pro Asp Val Asp Asp Thr Ala Met Val Val Leu Ala
370 375 380

Leu Asn Gly Ile Gln Leu Pro Asp Glu Gly Lys Arg Arg Asp Ala Leu
385 390 395 400

Thr Arg Gly Phe Arg Trp Leu Arg Glu Met Gln Ser Ser Asn Gly Gly
405 410 415

Trp Gly Ala Tyr Asp Val Asp Asn Thr Arg Gln Leu Thr Lys Ser Asp
420 425 430

Ser Ile Phe Ala Thr Ser Gly Glu Val Ile Asp Pro Pro Ser Glu Asp
435 440 445

Val Thr Ala His Val Leu Glu Cys Phe Gly Ser Phe Gly Tyr Asp Glu
450 455 460

Ala Trp Lys Val Ile Arg Lys Ala Val Glu Tyr Leu Lys Ala Gln Gln
465 470 475 480

Arg Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr
485 490 495

Gly Ile Gly Ala Val Val Pro Gly Leu Lys Ala Val Gly Val Asp Met
500 505 510

Arg Glu Pro Trp Val Gln Lys Ser Leu Asp Trp Leu Val Glu His Gln
515 520 525

Asn Glu Asp Gly Gly Trp Gly Glu Asp Cys Arg Ser Tyr Asp Asp Pro
530 535 540

Arg Leu Ala Gly Gln Gly Val Ser Thr Pro Ser Gln Thr Ala Trp Ala
545 550 555 560

Leu Met Ala Leu Ile Ala Gly Gly Arg Val Glu Ser Asp Ala Val Leu
565 570 575

Arg Gly Val Thr Tyr Leu His Asp Thr Gln Arg Ala Asp Gly Gly Trp
580 585 590

Asp Glu Glu Val Tyr Thr Gly Thr Gly Phe Pro Gly Asp Phe Tyr Leu
595 600 605

Ala Tyr Thr Met Tyr Arg Asp Ile Leu Pro Val Trp Ala Leu Gly Arg
610 615 620

Tyr Gln Glu Ala Met Gln Arg Ile Arg Gly
625 630


<210> 19
<211> 236
<212> PRT
<213> Alicyclobacillus acidoterrestris

<400> 19
Gly Gly Trp Met Phe Gln Ala Ser Ile Ser Pro Ile Trp Asp Thr Gly
1 5 10 15

Leu Thr Val Leu Ala Leu Arg Ser Ala Gly Leu Pro Pro Asp His Pro
20 25 30

Ala Leu Ile Lys Ala Gly Glu Trp Leu Val Ser Lys Gln Ile Leu Lys
35 40 45

Asp Gly Asp Trp Lys Val Arg Arg Arg Lys Ala Lys Pro Gly Gly Trp
50 55 60

Ala Phe Glu Phe His Cys Glu Asn Tyr Pro Asp Val Asp Asp Thr Ala
65 70 75 80

Met Val Val Leu Ala Leu Asn Gly Ile Gln Leu Pro Asp Glu Gly Lys
85 90 95

Arg Arg Asp Ala Leu Thr Arg Gly Phe Arg Trp Leu Arg Glu Met Gln
100 105 110

Ser Ser Asn Gly Gly Trp Gly Ala Tyr Asp Val Asp Asn Thr Arg Gln
115 120 125

Leu Thr Asn Arg Ile Pro Phe Cys Asn Phe Gly Glu Val Ile Asp Pro
130 135 140

Pro Ser Glu Asp Val Thr Ala His Val Leu Glu Cys Phe Gly Ser Phe
145 150 155 160

Gly Tyr Asp Glu Ala Trp Lys Val Ile Arg Lys Ala Val Glu Tyr Leu
165 170 175

Lys Ala Gln Gln Arg Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Val
180 185 190

Asn Tyr Val Tyr Gly Ile Gly Ala Val Val Pro Gly Leu Lys Ala Val
195 200 205

Gly Val Asp Met Arg Glu Pro Trp Val Gln Lys Ser Leu Asp Trp Leu
210 215 220

Val Glu His Gln Asn Glu Asp Gly Gly Trp Gly Glu
225 230 235


<210> 20
<211> 637
<212> PRT
<213> Anabaena variabilis

<400> 20
Met Arg Thr Gln Asp Arg Val Gln Val Asn Ser Ile Ala Glu Ala Ile
1 5 10 15

Ala Ala Ser Gln Lys Tyr Leu Leu Ser Leu Gln Asn Pro Thr Gly Tyr
20 25 30

Trp Trp Ala Glu Leu Glu Ser Asn Val Thr Ile Thr Ala Glu Val Val
35 40 45

Leu Leu His Lys Ile Trp Gly Thr Asp Lys Thr Arg Pro Leu His Lys
50 55 60

Ile Glu Ala Tyr Leu Arg Ser Gln Gln Lys Gln His Gly Gly Trp Glu
65 70 75 80

Leu Phe Tyr Gly Asp Gly Gly Glu Leu Ser Thr Ser Val Glu Ala Tyr
85 90 95

Met Ala Leu Lys Leu Leu Gly Val Pro Ala Thr Asp Pro Ala Met Ile
100 105 110

Gln Ala Arg Asp Phe Ile Leu Gln Arg Gly Gly Ile Ser Lys Thr Arg
115 120 125

Ile Phe Thr Lys Phe His Leu Ala Leu Ile Gly Cys Tyr Asn Trp Arg
130 135 140

Gly Leu Pro Ser Leu Pro Ala Trp Val Met Leu Leu Pro Asn Gln Phe
145 150 155 160

Pro Val Asn Ile Tyr Glu Met Ser Ser Trp Ala Arg Ser Ser Thr Val
165 170 175

Pro Leu Leu Ile Val Phe Asp Gln Lys Pro Val Tyr Gln Val Asn Pro
180 185 190

Ala Ile Thr Leu Asp Glu Leu Tyr Ala Glu Gly Val Glu Asn Val Arg
195 200 205

Tyr Glu Leu Pro Arg Ser Gly Asp Trp Thr Asp Leu Phe Leu Thr Leu
210 215 220

Asp Glu Gly Phe Lys Leu Ala Glu Ser Phe Asn Phe Ile Pro Phe Arg
225 230 235 240

Glu Glu Gly Ile Lys Ala Ala Glu Lys Trp Ile Ile Glu Arg Gln Glu
245 250 255

Ala Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn Ser Met
260 265 270

Leu Ala Leu Arg Val Leu Gly Tyr Ala Thr Asn Asp Pro Ile Val Glu
275 280 285

Arg Gly Leu Gln Ala Ile Asp Asn Phe Ala Ile Glu Thr Ala Asp Cys
290 295 300

Tyr Arg Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Trp Val
305 310 315 320

Ile Arg Ala Leu Ile Asp Ser Gly Met Ala Pro Asp His Pro Ala Ile
325 330 335

Val Lys Ala Gly Glu Trp Leu Leu Gln Lys Gln Ile Phe Asp Tyr Gly
340 345 350

Asp Trp Asn Val Lys Asn Arg Gln Gly Gln Pro Gly Ala Trp Ala Phe
355 360 365

Glu Phe Asp Asn Arg Phe Tyr Pro Asp Val Asp Asp Thr Ala Val Val
370 375 380

Val Met Ala Leu His Ala Ala Lys Leu Pro His Glu Gln Leu Lys Gln
385 390 395 400

Lys Ala Cys Asp Arg Ala Leu Gln Trp Val Ala Ser Met Gln Cys Lys
405 410 415

Pro Gly Gly Trp Ala Ala Phe Asp Ile Asp Asn Asp Gln Asp Trp Leu
420 425 430

Asn Ala Val Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp Pro Asn Thr
435 440 445

Ala Asp Val Thr Ala Arg Val Ile Glu Met Leu Gly Ala Cys Asn Leu
450 455 460

Ser Ile Asp Ser His Asp Leu Glu Arg Ala Leu Thr Tyr Leu Leu Asn
465 470 475 480

Glu Gln Glu Ala Glu Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr
485 490 495

Ile Tyr Gly Thr Ser Gly Val Leu Cys Ala Leu Ala Leu Ile Asn Pro
500 505 510

Gln Lys Tyr Gln Arg His Ile Gln Gln Gly Ala Thr Trp Leu Val Gly
515 520 525

Cys Gln Asn Pro Asp Gly Gly Trp Gly Glu Thr Cys Phe Ser Tyr Asn
530 535 540

Asp Pro Ser Leu Lys Gly Gln Gly Asp Ser Thr Pro Ser Gln Thr Ala
545 550 555 560

Trp Ala Leu Ile Gly Leu Ile Ala Ala Gly Glu Ala Thr Gly Asn Phe
565 570 575

Ala His Asp Val Ile Glu Arg Gly Ile Asn His Leu Val Ser Thr Gln
580 585 590

Gln Pro Asp Gly Ser Trp Phe Glu Ala Tyr Phe Thr Gly Thr Gly Phe
595 600 605

Pro Cys His Phe Tyr Leu Lys Tyr His Tyr Tyr Gln Gln Tyr Phe Pro
610 615 620

Leu Ile Ala Leu Gly Arg Tyr Gln Ala Ile Asn Pro Leu
625 630 635


<210> 21
<211> 654
<212> PRT
<213> Anaeromyxobacter sp.

<400> 21
Met Ser Gly Glu Val Arg Val Ala Gly Asp Ala Leu Ala Glu Asp Ala
1 5 10 15

Gly Arg Ala Ala Ala Ala Ala Ser Gln Tyr Leu Tyr Arg Thr Gln Gln
20 25 30

Arg Asp His Trp Arg Ala Glu Leu Glu Ser Asn Val Thr Val Thr Ala
35 40 45

Glu Tyr Val Leu Leu Arg Gln Ala Leu Gly Leu Asp Leu Glu Glu Arg
50 55 60

Arg Asp Ala Leu Val Arg Tyr Leu Cys Ser Arg Gln Lys Ala Asp Gly
65 70 75 80

Ser Phe Gly Ile Ala Ser Thr Leu Pro Gly Asp Val Ser Thr Thr Ala
85 90 95

Glu Ala Tyr Leu Ala Leu Arg Leu Leu Gly Leu Asp Arg Glu Asp Glu
100 105 110

Arg Leu Arg Ala Ala Glu Arg Phe Ile Arg Gly Ala Gly Gly Leu Ala
115 120 125

Arg Val Arg Val Phe Thr Arg Ile Asn Leu Ala Leu Phe Gly Leu Phe
130 135 140

Pro Trp Glu Ala Val Pro Thr Val Pro Ala Glu Leu Ile Phe Leu Pro
145 150 155 160

Arg Trp Ala Pro Val Asn Val Tyr Arg Leu Ala Ser Trp Ala Arg Ser
165 170 175

Thr Met Val Pro Leu Phe Val Leu Phe His His Arg Pro Val Phe Ala
180 185 190

Leu Pro Gly Gly Ala Gly Ser Asp Trp Leu Asp His Leu Trp Leu Gly
195 200 205

Pro Gly Asp Lys Arg Val Pro Tyr Arg Thr Ser Val Met Glu Thr Val
210 215 220

Arg Arg His Gly Pro Gly Trp Lys Ala Phe Phe Asn Ala Ala Asp Ala
225 230 235 240

Trp Leu Arg Val His Asp Arg Leu Arg His Leu Pro Pro Leu Gly Arg
245 250 255

Leu Arg Thr Glu Ala Leu Arg Ala Cys Glu Glu Trp Ile Leu Ala Arg
260 265 270

Gln Glu Ala Ser Gly Asp Trp Ala Gly Ile Phe Pro Pro Met Leu Asn
275 280 285

Gly Val Leu Ala Leu His Val Ala Gly His Gly Leu Asp Ala Ala Pro
290 295 300

Val Arg Arg Gly Leu Glu Ala Ile Glu Arg Phe Ala Val Ser Asp Arg
305 310 315 320

Glu Gly Phe Arg Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Ile
325 330 335

Leu Ala Leu Ile Gly Leu Leu Asp Ser Gly Glu Ser Pro Thr Asp Pro
340 345 350

Arg Leu Val Ala Ala Arg Arg Trp Ile Glu Gly Met Gln Leu Thr Asn
355 360 365

Asp Trp Gly Asp Trp Lys Val Tyr Asp Pro Arg Gly Glu Pro Gly Gly
370 375 380

Trp Ala Phe Glu Tyr Ala Asn Ser Trp Tyr Pro Asp Val Asp Asp Thr
385 390 395 400

Ala Ala Val Ile Val Gly Leu Leu Lys His Asp Pro Ala Ser Arg Ala
405 410 415

Gly Glu Thr Val Arg Arg Ala Ala Ala Trp Val Ala Ser Met Gln Asn
420 425 430

Arg Asp Gly Gly Trp Ala Ala Phe Asp Val Asn Asn Asp Arg Leu Phe
435 440 445

Leu Asn Glu Ile Pro Phe Ser Asp Met Asp Ser Leu Cys Asp Pro Ser
450 455 460

Ser Pro Asp Val Thr Gly Arg Val Leu Glu Ala Phe Gly Met Leu Asp
465 470 475 480

Ala Pro His Leu Arg Ala Ala Cys Arg Arg Gly Val Ala Tyr Leu Arg
485 490 495

Arg Ala Gln Glu Pro Glu Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn
500 505 510

Tyr Val Tyr Gly Thr Ser Asn Val Leu Asn Gly Leu Ala Arg Gln Arg
515 520 525

Val Pro Ala Ser Asp Pro Met Val Ala Arg Ala Leu Gly Trp Leu Asp
530 535 540

Ser Val Gln Asn Ala Asp Gly Gly Phe Gly Glu Gly Leu Glu Ser Tyr
545 550 555 560

Ala Asp Arg Ala Ala Met Gly Arg Gly Pro Ser Thr Ala Ser Gln Thr
565 570 575

Ala Trp Gly Val Met Gly Leu Leu Ala Tyr Arg Ala Ala Asp Asp Ala
580 585 590

Ala Val Arg Arg Gly Ile Ala Trp Leu Val Glu Arg Gln Leu Ala Asp
595 600 605

Gly Glu Ala Gln Gly Ser Trp Glu Glu Glu Ala Phe Thr Gly Thr Gly
610 615 620

Phe Pro Arg His Phe Tyr Leu Arg Tyr His Leu Tyr Arg His Tyr Phe
625 630 635 640

Pro Leu Met Ala Leu Gly Arg Phe Cys Ala Gln Gly Arg Gly
645 650


<210> 22
<211> 710
<212> PRT
<213> Aspergillus clavatus

<400> 22
Met Ala Thr Leu Thr Thr Met Ala Thr Thr Ala Thr Met Ala Thr Thr
1 5 10 15

Glu Ala Ser Gln Pro Leu Glu Ala Gln Ala Arg Thr Ala Leu Thr Lys
20 25 30

Ala Thr Ser Tyr Ala Trp Glu Ile Ile Ser Asn Arg His Trp Cys Gly
35 40 45

Glu Leu Glu Ser Asn Val Thr Val Thr Cys Glu His Ile Phe Phe Leu
50 55 60

Tyr Val Leu Tyr Gln His Ile Asp Pro Asp Glu Gly Ser Gln Tyr Arg
65 70 75 80

Gln Trp Leu Leu Ser Gln Gln Asn Ala Asp Gly Ser Trp Gly Ile Ala
85 90 95

Pro Asn Tyr Pro Gly Asp Val Ser Thr Ser Ala Glu Ala Tyr Leu Ala
100 105 110

Leu Arg Ile Ile Gly Met Ser Pro Asp Ser Pro Glu Leu Phe Gln Ala
115 120 125

Arg Thr Phe Ile Arg Ala Ala Gly Gly Leu Ser Lys Met Arg Met Phe
130 135 140

Thr Arg Ile Phe Phe Ala Glu Phe Gly Leu Val Pro Trp Thr Ala Ile
145 150 155 160

Pro Gln Leu Pro Ala Glu Phe Ile Leu Val Pro Ala His Phe Pro Ile
165 170 175

Ser Ile Tyr Arg Leu Ala Ser Trp Ala Arg Ser Asn Val Val Pro Leu
180 185 190

Leu Ile Ile Ala His His Arg Pro Leu Tyr Pro Leu Pro Asn Gly Leu
195 200 205

His Lys Gln Asn Pro Phe Leu Asp Glu Leu Trp Leu Asp Pro Ala Thr
210 215 220

Lys Pro Leu Pro Tyr Gly Ser Leu Asp Pro Thr Asp Pro Leu Ser Phe
225 230 235 240

Val Phe Thr Ile Leu Asp Lys Ala Leu Ser Tyr Leu Gly Gly Leu Arg
245 250 255

Arg Cys Pro Thr Arg Gly Tyr Ala Arg Arg Arg Cys Ile Gln Trp Ile
260 265 270

Leu Gln His Gln Glu Lys Ala Gly Asp Trp Ala Gly Ile Ile Pro Pro
275 280 285

Met His Ala Gly Ile Lys Ala Leu Trp Leu Glu Gly Tyr Lys Leu His
290 295 300

Asp Glu Pro Ile Gln Leu Gly Leu Ala Ala Ile Glu Arg Phe Thr Trp
305 310 315 320

Thr Asp Asn Arg Gly Lys Arg Leu Gln Cys Cys Ile Ser Pro Val Trp
325 330 335

Asp Thr Val Leu Met Ile Arg Ala Leu Gln Asp Thr Pro Ala Ser Leu
340 345 350

Gly Ile Lys Ser Asp Pro Arg Ile Ala Asp Ala Leu Ala Trp Thr Ala
355 360 365

Glu Asn Gln His Arg Gly Pro Glu Gly Asp Trp Arg Val Tyr Gln Pro
370 375 380

Asn Ile Pro Val Gly Gly Trp Ala Phe Glu Tyr Ser Asn Thr Trp Tyr
385 390 395 400

Pro Asp Ile Asp Asp Thr Ala Ala Ala Val Leu Ala Phe Leu Thr His
405 410 415

Asp Pro Ala Thr Ala Arg Ser Arg Leu Val Arg Asp Ala Val Leu Trp
420 425 430

Ile Val Gly Met Gln Asn Ala Asp Gly Gly Trp Ala Ala Phe Asp His
435 440 445

Glu Asn Asn Arg Leu Phe Leu Asn Lys Ile Pro Phe Ser Asp Met Glu
450 455 460

Ser Leu Cys Asp Pro Ser Thr Pro Asp Val Thr Gly Arg Thr Ile Glu
465 470 475 480

Cys Leu Gly Met Leu Arg Asp Leu Leu Met Leu Pro Ala Glu Lys Ala
485 490 495

Gly Lys Lys Gly Glu Lys Tyr Gly Tyr Pro Asp Gly Glu Arg Asp Ala
500 505 510

Ala Ala Asp Ser His Leu Leu Lys Ile Ile Asn Thr Ala Cys Ala Arg
515 520 525

Ala Ile Pro Tyr Leu Ile Arg Thr Gln Glu Ala Thr Gly Ala Trp Tyr
530 535 540

Gly Arg Trp Ala Val Asn Tyr Val Tyr Gly Thr Cys Leu Val Leu Cys
545 550 555 560

Gly Leu Gln Tyr Phe Lys His Asp Pro Thr Phe Ala Pro Glu Ile Asp
565 570 575

Thr Met Ala Thr Arg Ala Val Lys Trp Leu Arg Gln Ile Gln Asn Ser
580 585 590

Asp Gly Gly Trp Gly Glu Ser Val Leu Ser Tyr Arg Glu Pro Trp Arg
595 600 605

Ala Gly Cys Gly Pro Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Met
610 615 620

Gly Leu Leu Thr Val Cys Gly Gly Glu Asp Arg Ser Val Gln Arg Gly
625 630 635 640

Val Arg His Leu Val Asp Thr Gln Asp Asp Ile Leu Ser Lys Gly Glu
645 650 655

Gly Gly Ala Ala Ala Trp Thr Glu Arg Glu Phe Thr Ser Thr Gly Phe
660 665 670

Pro Asn His Phe Tyr Ile Ser Tyr Thr Leu Tyr Arg Val Tyr Phe Pro
675 680 685

Ile Thr Ala Leu Gly Arg Tyr Leu Ser Leu Val Glu Gly Gly Lys Lys
690 695 700

Glu Asn Gly Gly Gly Ala
705 710


<210> 23
<211> 673
<212> PRT
<213> Aspergillus flavus

<400> 23
Met Thr Thr Gly His Arg Gln Phe Asp Asp Gly Leu Ser Glu Arg Glu
1 5 10 15

Arg Leu Ile His Glu Ala Gly Leu Thr Leu Gln Arg Ser Met Asp Tyr
20 25 30

Ala Tyr Asn Val Val Arg Ser Asp Gly His Trp Cys Gly Glu Met Ser
35 40 45

Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Phe Leu Arg Gln Ala Leu
50 55 60

Gly Leu Asp Leu Lys Thr Asp Gly Ala Ala Tyr Cys Arg His Ile Leu
65 70 75 80

Ser Gln Gln Asn Ser Asp Gly Ser Trp Gly Leu Ala Pro Glu Tyr Pro
85 90 95

Gly Asp Val Ser Thr Thr Thr Glu Ala Tyr Leu Ala Leu Lys Met Leu
100 105 110

Gly Leu Ser Thr Asp Ala Pro Ala Met Gln Gln Ala Lys Ala Phe Val
115 120 125

Leu Asn Ala Gly Gly Val Ala Lys Val Arg Val Phe Thr Arg Ile Phe
130 135 140

Leu Ala Thr Phe Gly Leu Phe Pro Trp Lys Ala Val Pro Gln Leu Pro
145 150 155 160

Val Glu Leu Ile Leu Leu Pro Ser Ala Cys Pro Ile Asn Ile Tyr Lys
165 170 175

Phe Ala Ser Trp Ala Arg Gly Thr Ile Ala Pro Leu Leu Ile Ile Cys
180 185 190

His His Gln Pro Val Tyr Ala Leu Pro Asn Gly Val Phe Ala Glu Asn
195 200 205

Glu Tyr Leu Asp Glu Leu Trp Gln Asp Pro Thr Asn Lys Ser Glu Pro
210 215 220

Tyr Ser Pro Ser Ile Trp Glu Leu Leu Ser Gln Gly Asp Ile Thr Gly
225 230 235 240

Leu Thr Phe Ser Leu Leu Asp Lys Leu Leu Tyr Gln Leu Asn Gly Leu
245 250 255

Arg Ser Ile Pro Leu Leu Arg Ser Tyr Ala Leu Lys Gln Cys Met Lys
260 265 270

Trp Ile Leu Glu Arg Gln Glu Pro Thr Gly Asp Trp Ala Gly Ile Phe
275 280 285

Pro Pro Met His Ala Ser Val Tyr Ala Phe Val Leu Glu Gly Tyr Lys
290 295 300

Leu Glu Asp Pro Pro Val Arg Leu Gly Ile Glu Ala Leu Glu Asn Phe
305 310 315 320

Ala Trp Glu Asp Ala Lys Gly Lys Arg Val Gln Pro Cys Val Ser Pro
325 330 335

Val Trp Asp Thr Thr Leu Met Ser Ile Ala Leu Ser Asp Ala Ala Thr
340 345 350

Pro Asn His Gln Ile Val Asp Arg Ala Ile Gln Trp Ile Arg Asp Arg
355 360 365

Gln Leu Leu Glu Pro Arg Gly Asp Trp Arg Val Tyr Arg Pro Arg Leu
370 375 380

Ala Pro Gly Gly Phe Ser Phe Glu Tyr Thr Asn Ser His Tyr Pro Asp
385 390 395 400

Ile Asp Asp Ser Ala Ala Ile Ile Leu Ala Gln Val Lys His Asp Pro
405 410 415

Ile Ser Ala Asn Ser Ser Ser Val Ile Ala Ala Ala Thr Trp Ile Leu
420 425 430

Gly Met Gln Asn Pro Asp Gly Gly Trp Ala Ala Phe Asp Val Glu Asn
435 440 445

Asp Lys Leu Phe Leu Asn Lys Ile Pro Phe Ser Asp Met Asp Ser Leu
450 455 460

Cys Asp Thr Ser Cys Ala Asp Ile Thr Gly Arg Ile Leu Glu Ala Phe
465 470 475 480

Gly Leu Leu Ile Arg Arg Val Pro Asp Lys Asp Ser Ser Gln Leu Phe
485 490 495

Gln Leu Leu Pro Ala Ile Arg Ala Ala Cys Arg Arg Gly Ile Arg Tyr
500 505 510

Leu Ala Ser Thr Gln Glu Ala Asn Gly Ala Trp Phe Gly Arg Trp Gly
515 520 525

Cys Asn Tyr Ile Tyr Gly Thr Ser His Ala Leu Cys Gly Leu Ala Tyr
530 535 540

Phe Leu Gln Glu Asp Gln Gln Val Pro Ala Met Val Gln Pro Ala Leu
545 550 555 560

Gln Trp Leu Lys Ser Gln Gln Asn Asp Asp Gly Gly Trp Gly Glu Ser
565 570 575

Leu Leu Ser Tyr Gln Ser Pro Glu Arg Lys Glu Gln Arg Ser Thr Ala
580 585 590

Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Leu Ala His Leu Pro His
595 600 605

Thr Asp Ile Val Ile Glu Arg Gly Ile Arg Trp Leu Val Ser Ser Gln
610 615 620

Arg Pro Val Glu Thr Leu Gly Ser Thr Trp Pro Glu Pro Val Tyr Thr
625 630 635 640

Gly Thr Gly Phe Pro Asn His Phe Tyr Leu Gly Tyr Asp Tyr Tyr Arg
645 650 655

His Tyr Phe Pro Met Met Ala Leu Gly Arg Tyr Leu Arg Gly Val Gln
660 665 670

Gly


<210> 24
<211> 738
<212> PRT
<213> Aspergillus fumigatus

<400> 24
Met Leu Gly Ala Ile Arg Glu Pro Pro Ile Asp Val Gln Ile Ala Leu
1 5 10 15

His Ser Arg Asp Asp Asn Gln Thr Gly Leu Val Leu Arg Gly Thr Arg
20 25 30

Arg Thr Val Asp Arg Val Leu Lys Gly Leu Cys Ser Ser Pro Cys Phe
35 40 45

Phe Cys Ser Val Ser Leu Thr Met Ala Thr Leu Thr Thr Thr Met Ala
50 55 60

Thr Thr Ala Thr Met Ala Thr Thr Glu Ala Ser Lys Pro Leu Glu Ala
65 70 75 80

Gln Ala Arg Thr Ala Leu Thr Lys Ala Thr Asn Tyr Ala Trp Glu Ile
85 90 95

Phe Ser Asn Arg His Trp Cys Gly Glu Leu Glu Ser Asn Val Thr Val
100 105 110

Thr Cys Glu His Ile Phe Phe Leu Tyr Val Leu Tyr Gln His Ile Asp
115 120 125

Pro Gly Glu Gly Ser Gln Tyr Arg Gln Trp Leu Leu Ser Gln Gln Asn
130 135 140

Ser Asp Gly Ser Trp Gly Ile Ala Pro Asn Tyr Pro Gly Asp Ile Ser
145 150 155 160

Thr Ser Ala Glu Ala Tyr Leu Ala Leu Arg Ile Ile Gly Met Ser Thr
165 170 175

Asp Ser Pro Glu Leu Tyr Arg Ala Arg Thr Phe Ile Arg Ala Ala Gly
180 185 190

Gly Leu Ser Lys Met Arg Met Phe Thr Arg Ile Phe Phe Ala Glu Phe
195 200 205

Gly Leu Val Pro Trp Thr Ala Ile Pro Gln Leu Pro Ala Glu Phe Ile
210 215 220

Leu Val Pro Ala His Phe Pro Ile Ser Ile Tyr Arg Leu Ala Ser Trp
225 230 235 240

Ala Arg Ser Asn Val Val Pro Leu Leu Ile Ile Ala His His Arg Pro
245 250 255

Leu Tyr Pro Leu Pro Asn Gly Leu His Lys Gln Asn Pro Phe Leu Asp
260 265 270

Glu Leu Trp Leu Asp Pro Ala Thr Lys Pro Leu Pro Tyr Gly Ser Ser
275 280 285

Asp Pro Thr Asp Pro Val Ala Phe Val Phe Thr Ile Leu Asp Lys Ala
290 295 300

Leu Ser Tyr Leu Gly Gly Leu Arg Arg Ser Pro Thr Arg Gly Tyr Ala
305 310 315 320

Arg Arg Arg Cys Val Gln Trp Ile Leu Gln His Gln Glu Lys Ala Gly
325 330 335

Asp Trp Ala Gly Ile Ile Pro Pro Met His Ala Gly Ile Lys Ala Leu
340 345 350

Leu Leu Glu Gly Tyr Lys Leu His Asp Glu Pro Ile Gln Leu Gly Leu
355 360 365

Ala Ala Ile Glu Arg Phe Thr Trp Ala Asp Asn Arg Gly Lys Arg Leu
370 375 380

Gln Cys Cys Ile Ser Pro Val Trp Asp Thr Val Leu Met Ile Arg Ala
385 390 395 400

Leu Gln Asp Thr Pro Ala Ser Leu Gly Ile Lys Leu Asp Pro Arg Ile
405 410 415

Ala Asp Ala Leu Ala Trp Thr Ala Glu Asn Gln His Arg Gly Pro Glu
420 425 430

Gly Asp Trp Arg Val Tyr Lys Pro Asn Ile Pro Val Gly Gly Trp Ala
435 440 445

Phe Glu Tyr His Asn Thr Trp Tyr Pro Asp Ile Asp Asp Thr Ala Ala
450 455 460

Ala Val Leu Ala Phe Leu Thr His Asp Pro Ala Thr Ala Arg Ser Arg
465 470 475 480

Leu Val Arg Asp Ala Val Leu Trp Ile Val Gly Met Gln Asn Ala Asp
485 490 495

Gly Gly Trp Ala Ala Phe Asp His Glu Asn Asn Gln Leu Phe Leu Asn
500 505 510

Lys Ile Pro Phe Ser Asp Met Glu Ser Leu Cys Asp Pro Ser Thr Pro
515 520 525

Asp Val Thr Gly Arg Thr Ile Glu Cys Leu Gly Met Leu Arg Asp Leu
530 535 540

Leu Met Arg Pro Ala Glu Asn Ala Glu Asn Gly Glu Lys Tyr Gly Tyr
545 550 555 560

Pro Asp Gly Glu Gly Asp Ala Ala Ala Asp Ala His Leu Leu Gln Ile
565 570 575

Ile Asn Thr Ala Cys Ala Arg Ala Ile Pro Tyr Leu Ile Arg Ser Gln
580 585 590

Glu Ala Thr Gly Thr Trp Tyr Gly Arg Trp Ala Val Asn Tyr Val Tyr
595 600 605

Gly Thr Cys Leu Val Leu Cys Gly Leu Gln Tyr Phe Lys His Asp Pro
610 615 620

Lys Phe Ala Pro Glu Ile Gln Ala Met Ala Ala Arg Ala Val Lys Trp
625 630 635 640

Leu Lys Gln Val Gln Asn Ser Asp Gly Gly Trp Gly Glu Ser Leu Leu
645 650 655

Ser Tyr Arg Glu Pro Trp Arg Ala Gly Cys Gly Pro Ser Thr Pro Ser
660 665 670

Gln Thr Ala Trp Ala Leu Met Gly Ile Leu Thr Val Cys Gly Gly Glu
675 680 685

Asp Arg Ser Val Gln Arg Gly Val Arg His Leu Val Asp Thr Gln Asp
690 695 700

Asp Thr Leu Ser Gln Gly Asp Gly Gly Ala Ala Ala Trp Thr Glu Arg
705 710 715 720

Glu Phe Thr Ile Arg Glu Pro Leu His Glu Ala Ser Gln Arg Ile Gly
725 730 735

Ser Asp


<210> 25
<211> 689
<212> PRT
<213> Aspergillus fumigatus

<400> 25
Met Leu Gln Thr Glu Ala Ile Thr Thr Glu Gly Leu Arg Val Arg Ser
1 5 10 15

Leu Ser Pro Asp Asp Pro Leu Leu Pro Arg Ile Lys Gln Ala Ile Lys
20 25 30

Leu Ser Gly Gln His Ser Arg Gly Glu Met His Ser Asp Gly His Trp
35 40 45

Cys Gly Glu Val Lys Thr Asn Ala Thr Thr Ser Ala Glu His Val Leu
50 55 60

Leu Cys Gln Ala Leu Gly Ile Asn Leu Asp Ala Asp Arg Glu Ala Phe
65 70 75 80

Ile Ser Trp Phe Arg Cys Thr Gln Gly Ala Asp Gly Gly Trp Ser Thr
85 90 95

Ala Pro Asp Gln Ala Gly Asp Ile Ser Val Thr Val Glu Ala Tyr Leu
100 105 110

Ala Leu Lys Ile Leu Gly Leu Ser Glu Asp Asp Ala Ala Met Arg Arg
115 120 125

Ala Arg Asp Phe Ala Ile Ala Ala Gly Gly Val Ala Lys Val Arg Ile
130 135 140

Phe Thr Arg Ile Tyr Leu Ala Leu Phe Gly Leu Phe Pro Trp Ala Ala
145 150 155 160

Val Pro Glu Leu Pro Pro Glu Leu Ile Leu Leu Pro Ser Arg Val Pro
165 170 175

Val Ser Ile Tyr His Trp Ser Ala Trp Ala Arg Ala Thr Val Val Pro
180 185 190

Leu Leu Ile Ile Ser His His Arg Pro Ile Tyr Ala Leu Pro Gly Gly
195 200 205

Gly Lys Gly Thr Ser Ser Asp Tyr Leu Asp Glu Leu Trp Cys Asp Pro
210 215 220

Gln Asn Lys Met Ile Pro Tyr Asn His Asp Glu Pro Thr Ala Trp Arg
225 230 235 240

Ser Asp Pro Phe Ala Ser Ile Phe Thr Leu Ala Asp Ser Ile Leu His
245 250 255

Arg Leu Asp Gly Leu Arg Ser Phe Asn Pro Phe Arg Arg Phe Ala Leu
260 265 270

Gln Lys Cys Val Asp Trp Ile Leu Glu His Gln Glu Asp Met Gly Asp
275 280 285

Ile Gly Asp Ile Met Pro Pro Leu His Gly Ala Met Leu Ala Leu Arg
290 295 300

Leu Glu Gly Tyr Pro Leu His Ser Gly Pro Ile His Arg Gly Leu Glu
305 310 315 320

Ala Ile Glu Arg Phe Ala Tyr Arg Asp Lys Gln Gly Lys Arg Ile Gln
325 330 335

Thr Thr Val Ser Ala Phe Trp Asp Thr Ser Leu Met Leu Ile Ala Leu
340 345 350

Gly Asp Ala Gly Met Ala Ser Lys Pro Trp Leu Thr Arg Ser Leu Gly
355 360 365

Trp Leu Gln Gln His Gln Arg Leu Gly Asn Tyr Gly Asp Trp Lys Val
370 375 380

Asn Asn His Gly Leu Lys Ala Gly Gly Phe Ser Phe Gly Tyr Phe Asn
385 390 395 400

Thr Trp Tyr Pro Asp Val Asp Asp Thr Ala Ser Ala Val Leu Ala Met
405 410 415

Ile Arg Gln Asp Glu Arg Leu Val His Ser Ala Ser Val Leu Asp Ala
420 425 430

Leu Asn Trp Leu Leu Gly Met Gln Asn Thr Asp Gly Gly Trp Gly Ala
435 440 445

Phe Asp Arg Asp Asn Asp Lys His Phe Leu Asn Lys Ile Pro Phe Ser
450 455 460

Asp Met Asp Ala Leu Cys Asp Pro Ser Thr Pro Asp Val Thr Gly His
465 470 475 480

Val Leu Glu Ala Phe Gly Leu Phe Leu Ala Leu Ser Lys Ala Asp Ala
485 490 495

Leu Ala Asp Arg Val Val Ala Ala Ser Arg Arg Ala Ile Arg Tyr Leu
500 505 510

Ser Asp Thr His Val Leu Ser Arg Gly Trp Tyr Gly Arg Trp Gly Cys
515 520 525

Asn Tyr Ile Tyr Gly Thr Ser Ala Val Leu Cys Ala Leu Ala Tyr Phe
530 535 540

Gly Ser Glu Asn Asp Ala Leu Ser Gly Val Arg Val Met Lys Asp Ala
545 550 555 560

Ile Asn Gln Ala Ile Arg Trp Leu Glu Thr Val Gln Asn Pro Asp Gly
565 570 575

Gly Trp Gly Glu Thr Val Asp Ser Tyr Lys Asp Pro Ser Arg Ala Gly
580 585 590

Ser Gly Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Ile Met Ala Leu
595 600 605

Leu Pro Tyr Leu Pro Pro Ser Thr Glu Val Ile Gln Arg Gly Met Glu
610 615 620

Tyr Leu Leu Arg Thr Gln Thr Lys Thr Ala Ser Gln Gly Ala Thr Trp
625 630 635 640

His Glu Lys Ala Tyr Thr Ala Thr Gly Phe Pro Lys Tyr Phe Tyr Met
645 650 655

Gly Tyr Ser Leu Tyr Ala His Tyr Phe Pro Met Met Ala Leu Gly Arg
660 665 670

Tyr Ala Tyr Pro Cys Pro Ala Trp His Glu Asn Trp Arg Leu Lys Arg
675 680 685

Asp


<210> 26
<211> 671
<212> PRT
<213> Aspergillus fumigatus

<400> 26
Met Ala Thr Leu Thr Thr Thr Met Ala Thr Thr Ala Thr Met Ala Thr
1 5 10 15

Thr Glu Ala Ser Lys Pro Leu Glu Ala Gln Ala Arg Thr Ala Leu Thr
20 25 30

Lys Ala Thr Asn Tyr Ala Trp Glu Ile Phe Ser Asn Arg His Trp Cys
35 40 45

Gly Glu Leu Glu Ser Asn Val Thr Val Thr Cys Glu His Ile Phe Phe
50 55 60

Leu Tyr Val Leu Tyr Gln His Ile Asp Pro Gly Glu Gly Ser Gln Tyr
65 70 75 80

Arg Gln Trp Leu Leu Leu Gln Gln Asn Ser Asp Gly Ser Trp Gly Ile
85 90 95

Ala Pro Asn Tyr Pro Gly Asp Ile Ser Thr Ser Ala Glu Ala Tyr Leu
100 105 110

Ala Leu Arg Ile Ile Gly Met Ser Thr Asp Ser Pro Glu Leu Tyr Arg
115 120 125

Ala Arg Thr Phe Ile Arg Ala Ala Gly Gly Leu Ser Lys Met Arg Met
130 135 140

Phe Thr Arg Ile Phe Phe Ala Glu Phe Gly Leu Val Pro Trp Thr Ala
145 150 155 160

Ile Pro Gln Leu Pro Ala Glu Phe Ile Leu Val Pro Ala His Phe Pro
165 170 175

Ile Ser Ile Tyr Arg Leu Ala Ser Trp Ala Arg Ser Asn Val Val Pro
180 185 190

Leu Leu Ile Ile Ala His His Arg Pro Leu Tyr Pro Leu Pro Asn Gly
195 200 205

Leu His Lys Gln Asn Pro Phe Leu Asp Glu Leu Trp Leu Asp Pro Ala
210 215 220

Thr Lys Pro Leu Pro Tyr Gly Ser Ser Asp Pro Thr Asp Pro Val Ala
225 230 235 240

Phe Val Phe Thr Ile Leu Asp Lys Ala Leu Ser Tyr Leu Gly Gly Leu
245 250 255

Arg Arg Ser Pro Thr Arg Gly Tyr Ala Arg Arg Arg Cys Val Gln Trp
260 265 270

Ile Leu Gln His Gln Glu Lys Ala Gly Asp Trp Ala Gly Ile Ile Pro
275 280 285

Pro Met His Ala Gly Ile Lys Ala Leu Leu Leu Glu Gly Tyr Lys Leu
290 295 300

His Asp Glu Pro Ile Gln Leu Gly Leu Ala Ala Ile Glu Arg Phe Thr
305 310 315 320

Trp Ala Asp Asn Arg Gly Lys Arg Leu Gln Cys Cys Ile Ser Pro Val
325 330 335

Trp Asp Thr Arg Val Tyr Lys Pro Asn Ile Pro Val Gly Gly Trp Ala
340 345 350

Phe Glu Tyr His Asn Thr Trp Tyr Pro Asp Ile Asp Asp Thr Ala Ala
355 360 365

Ala Val Leu Ala Phe Leu Thr His Asp Pro Ala Thr Ala Arg Ser Arg
370 375 380

Leu Val Arg Asp Ala Val Leu Trp Ile Val Gly Met Gln Asn Ala Asp
385 390 395 400

Gly Gly Trp Ala Ala Phe Asp His Glu Asn Asn Gln Leu Phe Leu Asn
405 410 415

Lys Ile Pro Phe Ser Asp Met Glu Ser Leu Cys Asp Pro Ser Thr Pro
420 425 430

Asp Val Thr Gly Arg Thr Ile Glu Cys Leu Gly Met Leu Arg Asp Leu
435 440 445

Leu Met Arg Pro Ala Glu Asn Ala Glu Asn Gly Glu Lys Tyr Gly Tyr
450 455 460

Pro Asp Gly Glu Gly Asp Ala Ala Ala Asp Ala His Leu Leu Gln Ile
465 470 475 480

Ile Asn Thr Ala Cys Ala Arg Ala Ile Pro Tyr Leu Ile Arg Ser Gln
485 490 495

Glu Ala Thr Gly Thr Trp Tyr Gly Arg Trp Ala Val Asn Tyr Val Tyr
500 505 510

Gly Thr Cys Leu Val Leu Cys Gly Leu Gln Tyr Phe Lys His Asp Pro
515 520 525

Lys Phe Ala Pro Glu Ile Gln Ala Met Ala Ala Arg Ala Val Lys Trp
530 535 540

Leu Lys Gln Val Gln Asn Ser Asp Gly Gly Trp Gly Glu Ser Leu Leu
545 550 555 560

Ser Tyr Arg Glu Pro Trp Arg Ala Gly Cys Gly Pro Ser Thr Pro Ser
565 570 575

Gln Thr Ala Trp Ala Leu Met Gly Ile Leu Thr Val Cys Gly Gly Glu
580 585 590

Asp Arg Ser Val Gln Arg Gly Val Arg His Leu Val Asp Thr Gln Asp
595 600 605

Asp Thr Leu Ser Gln Gly Asp Gly Gly Ala Ala Ala Trp Thr Glu Arg
610 615 620

Glu Phe Thr Ser Thr Gly Phe Pro Asn His Phe Tyr Ile Ser Tyr Thr
625 630 635 640

Leu Tyr Arg Val Tyr Phe Pro Ile Thr Ala Leu Gly Arg Tyr Leu Ser
645 650 655

Leu Ile Glu Gly Gly Gln Glu Lys Lys Lys Lys Gly Gly Gly Thr
660 665 670


<210> 27
<211> 693
<212> PRT
<213> Aspergillus niger

<400> 27
Met Ala His Gln Glu Thr Met Ala Ser Glu Thr Ser Ile Ser Leu His
1 5 10 15

Thr Leu Ala Cys Asp Ala Thr Lys Leu Ala Gly Thr Tyr Ala Leu Arg
20 25 30

Gln Val Arg Glu Asp Gly His Trp Tyr Gly Glu Met Lys Ser Asn Ala
35 40 45

Thr Ile Thr Ala Glu Tyr Val Phe Leu Ala Gln Ala Leu Gly Phe Ser
50 55 60

Ile Glu Glu Asp Arg Asp Asp Leu Ile Lys Tyr Phe Leu Ser Glu Gln
65 70 75 80

Asn Thr Asp Gly Ser Trp Ser Leu Ala Tyr Asp Phe Pro Gly Asp Val
85 90 95

Ser Val Thr Ala Glu Ala Tyr Phe Ala Leu Cys Leu Leu Gly Leu Asp
100 105 110

Arg Ser His Pro Ala Met Ala Ser Ala Arg Glu Phe Thr Leu Ser Lys
115 120 125

Gly Gly Ile Ala Lys Val Arg Val Phe Thr Arg Met Phe Phe Ala Cys
130 135 140

Phe Gly Leu Phe Pro Trp Ser Ala Val Pro Glu Leu Pro Ala Glu Leu
145 150 155 160

Ile Leu Leu Pro Ala Ala Ala Pro Met Ser Ile Tyr Gln Leu Ala Ser
165 170 175

Trp Ala Arg Ala Thr Val Val Pro Met Leu Val Ile Arg His His Arg
180 185 190

Pro Ile Tyr Ala Leu Pro Asn Gly Arg Ser Ser Ser Asn Glu Tyr Leu
195 200 205

Asp Glu Leu Trp Val Asp Pro Thr Asp Lys Met Val Pro Tyr Ser Pro
210 215 220

Ser Leu Trp Ser Leu Trp Asn Asp Asp Leu Thr Ala Phe Gly Phe Thr
225 230 235 240

Leu Ala Asp Asn Ile Leu Lys Ala Leu Gly Gly Leu Arg Trp Phe Pro
245 250 255

Ser Arg Lys Ile Ala Leu Arg His Cys Val Ala Trp Ile Leu Glu Arg
260 265 270

Gln Glu Pro Glu Gly Asp Ile Gly Gly Ile Phe Pro Pro Leu His Ala
275 280 285

Ala Leu Phe Ala Leu Ala Leu Glu Gly Tyr Gly Leu Glu Ser Ser Pro
290 295 300

Val Arg Arg Gly Ile Asp Ala Leu Gln Asn Thr Tyr Ala Trp Arg Asp
305 310 315 320

Ser Thr Gly Leu Arg Ile Gln Gly Cys Ile Ser Pro Ile Leu Asp Thr
325 330 335

Ile Leu Met Thr Ile Gly Leu Ile Asp Ser Ser Leu Pro Ala Glu Ser
340 345 350

Pro Leu Val Ala Arg Ser Ser Arg Tyr Leu Lys Ala His Gln Gln Leu
355 360 365

Gly Asn Glu Gly Asp Trp Arg Val Tyr Asn Gly Asn Val Pro Ser Gly
370 375 380

Gly Phe Asn Phe Glu Tyr Phe Asn Ser Trp Tyr Pro Asp Ile Asp Asp
385 390 395 400

Thr Ala Ala Ala Ile Leu Ala Met Val Lys Gln Asp Pro Asn Leu Leu
405 410 415

Asp Leu Gly Pro Ile Leu Ser Ala Val Gln Trp Ile Leu Gly Leu Gln
420 425 430

Asn Asp Asp Gly Gly Trp Ala Ala Phe Asp Arg Glu Asn Asn Tyr Leu
435 440 445

Phe Leu Asn Lys Ile Pro Phe Ser Asp Met Asp Ser Phe Cys Asp Pro
450 455 460

Ser Thr Ala Asp Val Thr Gly Arg Val Ile Glu Cys Phe Gly Leu Asn
465 470 475 480

Gly Lys Asn Pro Ile Pro Arg Phe Phe Ile Asp Asp Met Ser Ser Ala
485 490 495

Thr Glu Arg Ala Ile Asp Phe Leu Ser Thr Glu Gln Glu Ala Asp Gly
500 505 510

Ser Trp Tyr Gly Arg Trp Gly Ser Asn Tyr Ile Tyr Gly Thr Ser Ala
515 520 525

Val Leu Cys Gly Leu Val Tyr His Leu Glu Gly Trp Asp Asp Thr Tyr
530 535 540

Pro Val Met Glu Lys Arg His Lys Val Asp Thr His Ala Ala Leu Asp
545 550 555 560

Trp Leu Lys Arg His Gln Asn Pro Asp Gly Gly Trp Gly Glu Arg Leu
565 570 575

Glu Ser Tyr Tyr Glu Pro Arg Leu Ala Gly Asn Gly Pro Ser Thr Ala
580 585 590

Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Leu Ala Tyr Leu Ala Pro
595 600 605

Thr Asp Glu Ser Ile Thr Arg Gly Ile Gln Tyr Leu Ser Arg Thr Gln
610 615 620

Ile Lys Glu Gly Glu Leu Ala Gly Ser Trp Lys Glu Asp His Tyr Thr
625 630 635 640

Gly Thr Gly Phe Pro Asn His Phe Tyr Leu Cys Tyr Thr Leu Tyr Ser
645 650 655

Gln Tyr Phe Pro Met Met Ala Leu Gly Arg Tyr Thr Ser Leu Ser Gly
660 665 670

Tyr Arg Pro Leu Glu Asn Leu Glu Ser Thr Val Glu Asp His Lys Gly
675 680 685

Asn Ser Ser Asp Cys
690


<210> 28
<211> 653
<212> PRT
<213> Aspergillus niger

<400> 28
Met Met Thr Leu Arg Glu Glu Gly His Lys Glu Gly Ile Thr Pro Gly
1 5 10 15

Lys Glu Gln Leu Thr Ser Asp Ile Glu His Ser Leu Lys Leu Ala Thr
20 25 30

Glu Tyr Ala Leu Ser Ser Ile Arg Ser Asp Gly His Trp Cys Gly Glu
35 40 45

Leu Arg Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Phe Leu Arg His
50 55 60

Ala Leu Gly Leu Asp Leu Arg Thr Asp Asn Ala Ala Tyr Cys Arg Tyr
65 70 75 80

Ile Leu Ser Gln Gln Asn Cys Asp Gly Ser Trp Gly Leu Ala Pro Glu
85 90 95

Tyr Pro Gly Asp Val Ser Thr Thr Thr Glu Ala Tyr Leu Ala Leu Lys
100 105 110

Leu Leu Gly Thr Ser Pro Asp Met Pro Ala Met Gln Gln Ala Arg Ala
115 120 125

Phe Val Arg Lys Ala Gly Gly Ala Glu Lys Val Arg Val Phe Thr Arg
130 135 140

Ile Phe Leu Ala Thr Phe Gly Leu Phe Pro Trp Asp Ala Val Pro Gln
145 150 155 160

Leu Pro Val Glu Leu Ile Leu Leu Pro Ser Ser Cys Pro Ile Asn Met
165 170 175

Tyr Thr Leu Ala Ser Trp Ala Arg Gly Thr Ile Ala Pro Leu Leu Ile
180 185 190

Ile Cys His His Gln Pro Val Tyr Ala Leu Pro Glu Asp Tyr Leu Asp
195 200 205

Glu Leu Trp Leu Asp Pro Thr Asp Lys Asn Val Pro Tyr Gly Ser Ser
210 215 220

Leu Arg Asp Leu Leu Ser Arg Gly Asp Ile Thr Gly Leu Ala Phe Ser
225 230 235 240

Val Val Asp Asn Leu Leu Tyr Tyr Leu Asn Gly Leu Arg Ser Val Pro
245 250 255

Leu Leu Arg Ser Tyr Ala Arg Arg Lys Cys Ile Gln Trp Ile Leu Glu
260 265 270

Arg Gln Glu Pro Thr Gly Asp Trp Ala Gly Ile Phe Pro Pro Met His
275 280 285

Ala Ser Ile Tyr Ala Phe Val Leu Glu Gly Tyr Glu Leu Asn Asp Pro
290 295 300

Pro Val Arg Leu Gly Ile Gln Ala Leu Glu Asn Phe Ala Trp Glu Asp
305 310 315 320

Glu Lys Gly Lys Arg Ile Gln Ala Cys Val Ser Pro Val Trp Asp Thr
325 330 335

Ala Leu Met Ser Ile Gly Leu Cys Asp Ala Met Ser Pro Asp Lys Gln
340 345 350

Ile Leu Gln Gln Ala Ile Thr Trp Ile Arg Asn Arg Gln Leu Leu Lys
355 360 365

Pro Cys Gly Asp Trp Arg Ile Tyr Arg Ser Lys Leu Ala Pro Gly Gly
370 375 380

Phe Ser Phe Glu Tyr Glu Asn Ser His Tyr Pro Asp Val Asp Asp Thr
385 390 395 400

Ala Ala Ile Ile Leu Ala Gln Leu Lys Gln Asp Pro Gln Ser Val Ala
405 410 415

Ser Asp Ser Val Ile Ala Ala Ala Thr Trp Ile Leu Gly Met Gln Asn
420 425 430

Pro Asp Gly Gly Trp Ala Ala Phe Asp Val Glu Asn Asp Lys Leu Phe
435 440 445

Leu Asn Lys Ile Pro Phe Ser Asp Met Asp Ser Leu Cys Asp Thr Ser
450 455 460

Cys Ala Asp Ile Thr Gly Arg Ile Leu Glu Ala Phe Gly Leu Met Met
465 470 475 480

Lys Arg Glu Leu Lys Arg Pro Val Leu Ser Pro Met Leu Arg His Ala
485 490 495

Cys Ile Arg Gly Ile Thr Tyr Leu Ala Ser Thr Gln Glu Ser Asn Gly
500 505 510

Ala Trp Phe Gly Arg Trp Gly Cys Asn Tyr Ile Tyr Gly Thr Cys His
515 520 525

Ala Leu Gly Leu Val Ala Pro Ala Leu Gln Trp Leu Lys Ser Lys Gln
530 535 540

Asn Asp Asp Gly Gly Trp Gly Glu Pro Leu Leu Ser Tyr Arg Thr Pro
545 550 555 560

Gly Thr Gln Leu Gln Gln Gln Ser Thr Pro Ser Gln Thr Ala Trp Ala
565 570 575

Leu Met Gly Leu Leu Ala His Leu Pro Leu Thr Asp Pro Ala Ile Glu
580 585 590

Arg Gly Ile Arg Trp Leu Val Cys Ser Gln Gln Pro Glu Lys Gly Asn
595 600 605

Gly Ala Ser Trp Pro Glu Ala Val Tyr Thr Gly Thr Gly Phe Pro Asn
610 615 620

His Phe Tyr Leu Gly Tyr Asp Tyr Tyr Arg His Tyr Phe Pro Met Met
625 630 635 640

Ala Leu Gly Arg Tyr Leu Gln Ala Ser Gln Ala Gln Ala
645 650


<210> 29
<211> 673
<212> PRT
<213> Aspergillus oryzae

<400> 29
Met Thr Thr Gly His Arg Gln Phe Asp Asp Gly Leu Ser Glu Arg Glu
1 5 10 15

Arg Leu Ile His Glu Ala Gly Leu Thr Leu Gln Arg Ser Met Asp Tyr
20 25 30

Ala Tyr Asn Val Val Arg Ser Asp Gly His Trp Cys Gly Glu Met Ser
35 40 45

Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Phe Leu Arg Gln Ala Leu
50 55 60

Gly Leu Asp Leu Lys Thr Asp Gly Ala Ala Tyr Cys Arg His Ile Leu
65 70 75 80

Ser Gln Gln Asn Ser Asp Gly Ser Trp Gly Leu Ala Pro Glu Tyr Pro
85 90 95

Gly Asp Val Ser Thr Thr Thr Glu Ala Tyr Leu Ala Leu Lys Met Leu
100 105 110

Gly Leu Ser Thr Asp Ala Pro Ala Met Gln Gln Ala Lys Ala Phe Val
115 120 125

Leu Asn Ala Gly Gly Val Ala Lys Val Arg Val Phe Thr Arg Ile Phe
130 135 140

Leu Ala Thr Phe Gly Leu Phe Pro Trp Lys Ala Val Pro Gln Leu Pro
145 150 155 160

Val Glu Leu Ile Leu Leu Pro Ser Ala Cys Pro Ile Asn Ile Tyr Lys
165 170 175

Phe Ala Ser Trp Ala Arg Gly Thr Ile Ala Pro Leu Leu Ile Ile Cys
180 185 190

His His Gln Pro Val Tyr Ala Leu Pro Asn Gly Val Phe Ala Glu Asn
195 200 205

Glu Tyr Leu Asp Glu Leu Trp Gln Asp Ser Thr Asn Lys Ser Glu Pro
210 215 220

Tyr Ser Pro Ser Ile Trp Glu Leu Leu Ser Gln Gly Asp Ile Thr Gly
225 230 235 240

Leu Thr Phe Ser Leu Leu Asp Lys Leu Leu Tyr Gln Leu Asn Gly Leu
245 250 255

Arg Ser Ile Pro Leu Leu Arg Ser Tyr Ala Leu Lys Gln Cys Met Lys
260 265 270

Trp Ile Leu Glu Arg Gln Glu Pro Thr Gly Asp Trp Ala Gly Ile Phe
275 280 285

Pro Pro Met His Ala Ser Val Tyr Ala Phe Val Leu Glu Gly Tyr Lys
290 295 300

Leu Glu Asp Pro Pro Val Arg Leu Gly Ile Glu Ala Leu Glu Asn Phe
305 310 315 320

Ala Trp Glu Asp Ala Lys Gly Lys Arg Val Gln Pro Cys Val Ser Pro
325 330 335

Val Trp Asp Thr Thr Leu Met Ser Ile Ala Leu Ser Asp Ala Ala Thr
340 345 350

Pro Asn His Gln Ile Val Asp Arg Ala Ile Gln Trp Ile Arg Asp Arg
355 360 365

Gln Leu Leu Glu Pro Arg Gly Asp Trp Arg Val Tyr Arg Pro Arg Leu
370 375 380

Ala Pro Gly Gly Phe Ser Phe Glu Tyr Thr Asn Ser His Tyr Pro Asp
385 390 395 400

Ile Asp Asp Ser Ala Ala Ile Ile Leu Ala Gln Val Lys His Asp Pro
405 410 415

Ile Ser Ala Asn Ser Ser Ser Val Ile Ala Ala Ala Thr Trp Ile Leu
420 425 430

Gly Met Gln Asn Pro Asp Gly Gly Trp Ala Ala Phe Asp Val Glu Asn
435 440 445

Asp Lys Leu Phe Leu Asn Lys Ile Pro Phe Ser Asp Met Asp Ser Leu
450 455 460

Cys Asp Thr Ser Cys Ala Asp Ile Thr Gly Arg Ile Leu Glu Ala Phe
465 470 475 480

Gly Leu Leu Ile Arg Arg Val Pro Asp Lys Asp Ser Ser Gln Leu Phe
485 490 495

Gln Leu Leu Pro Ala Ile Arg Ala Ala Cys Arg Arg Gly Ile Arg Tyr
500 505 510

Leu Ala Ser Thr Gln Glu Ala Asn Gly Ala Trp Phe Gly Arg Trp Gly
515 520 525

Cys Asn Tyr Ile Tyr Gly Thr Ser His Ala Leu Cys Gly Leu Ala Tyr
530 535 540

Phe Leu Gln Glu Asp Gln Gln Val Pro Ala Met Val Gln Pro Ala Leu
545 550 555 560

Gln Trp Leu Lys Ser Gln Gln Asn Asp Asp Gly Gly Trp Gly Glu Ser
565 570 575

Leu Leu Ser Tyr Gln Ser Pro Glu Arg Lys Glu Gln Arg Ser Thr Ala
580 585 590

Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Leu Ala His Leu Pro His
595 600 605

Thr Asp Ile Val Ile Glu Arg Gly Ile Arg Trp Leu Val Ser Ser Gln
610 615 620

Arg Pro Val Glu Thr Leu Gly Ser Thr Trp Pro Glu Pro Val Tyr Thr
625 630 635 640

Gly Thr Gly Phe Pro Asn His Phe Tyr Leu Gly Tyr Asp Tyr Tyr Arg
645 650 655

His Tyr Phe Pro Met Met Ala Leu Gly Arg Tyr Leu Arg Gly Val Gln
660 665 670

Gly


<210> 30
<211> 659
<212> PRT
<213> Azotobacter vinelandii

<400> 30
Met Glu Arg Ser Ser Leu Leu Val Pro Ala Ser Ile Asp Ser His Ser
1 5 10 15

Arg Glu Ser Glu Thr Thr Gly Leu Asp Gln Ala Ile Val Arg Ala Arg
20 25 30

Ala Ala Leu Leu Gly Arg Gln Gly Ala Asp Gly His Trp Cys Phe Glu
35 40 45

Leu Glu Ser Asp Cys Thr Ile Thr Ala Glu Tyr Ile Leu Met Met His
50 55 60

Phe Thr Asp Glu Ile Asp Glu Asp Leu Gln Glu Arg Met Ala Arg Tyr
65 70 75 80

Leu Arg Ala Thr Gln Val Gln Glu Thr His Gly Gly Trp Pro Gln Tyr
85 90 95

Val Gly Gly Ala Ile Asp Leu Ser Cys Thr Val Lys Ala Tyr Tyr Ala
100 105 110

Leu Lys Ala Ala Gly Asp Ser Pro Glu Ala Pro His Met Arg Arg Ala
115 120 125

Arg Glu Ala Val Leu Ala Leu Gly Gly Ala Ala Lys Ser Asn Val Phe
130 135 140

Thr Arg Ile Leu Leu Ala Met Phe Glu Gln Val Pro Trp Arg Ala Val
145 150 155 160

Pro Tyr Leu Pro Val Glu Ile Met Leu Leu Pro Arg Trp Ala Pro Ile
165 170 175

His Ile Glu Lys Met Ser Tyr Trp Ala Arg Thr Thr Leu Val Pro Leu
180 185 190

Thr Ile Leu Cys Ser Leu Lys Ala Arg Ala Ala Asn Pro Lys Arg Val
195 200 205

Asp Ile Arg Glu Leu Phe Val Thr Ala Pro Glu Gln Glu Arg His Tyr
210 215 220

Phe Leu Arg Gly Gly Leu Leu Asn Arg Ile Phe Leu Gly Leu Asp Lys
225 230 235 240

Phe Ala Arg Thr Leu Asp Arg Trp Met Pro Lys Ser Leu Arg Gln His
245 250 255

Ala Ile Arg Lys Ala Glu Ala Trp Phe Leu Pro Arg Met Asn Gly Glu
260 265 270

Asp Gly Leu Gly Ala Ile Phe Pro Pro Met Val Asn Cys Tyr Glu Ala
275 280 285

Met Ile Leu Leu Gly Tyr Pro Lys Asp His Pro Ala Arg Lys Thr Cys
290 295 300

Leu Arg Ser Ile Gln Lys Leu Ile Val His Arg Asp Asp Gly Ser Ala
305 310 315 320

Tyr Cys Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Trp Ser Ala
325 330 335

Met Ala Leu Ile His Ser Gly Asp Asp Thr Ala Thr Gln Thr Ala Ile
340 345 350

Ala Arg Ala Gly Asp Trp Leu Val Gln Arg Gln Glu Leu Asp Cys Arg
355 360 365

Gly Asp Trp Glu Ala Gln Ala Pro Gln Ala Ala Pro Gly Gly Trp Ala
370 375 380

Phe Gln Tyr Ala Asn Gly Tyr Tyr Pro Asp Ile Asp Asp Thr Ala Leu
385 390 395 400

Val Ala Ala Leu Leu His Ile Ser Asp Arg Arg Arg Gly Gln Pro Gly
405 410 415

Gln His Ala Phe Asn Ile Asp Arg Ala Val Asp Trp Met Leu Ala Leu
420 425 430

Gln Ser Arg Asn Gly Gly Phe Ala Ala Phe Asp Ala Asp Asn Thr His
435 440 445

Tyr Tyr Leu Asn Ala Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp
450 455 460

Pro Pro Thr Glu Asp Val Ser Gly Arg Val Ala Ala Cys Leu Gly Ile
465 470 475 480

Leu Lys Arg Asp Gln Asp Arg Asp Gly Leu Arg Arg Cys Ile Asp Tyr
485 490 495

Leu Arg Thr Thr Gln Gln Pro Asp Gly Ser Trp Trp Gly Arg Trp Gly
500 505 510

Ser Asn Tyr Ile Tyr Gly Thr Trp Ser Ala Leu Ser Gly Leu Ala Leu
515 520 525

Ala Gly Glu Asp Leu Arg Gln Pro Tyr Leu Arg Lys Ser Val Asp Trp
530 535 540

Leu Arg Thr Arg Gln His Pro Asp Gly Gly Trp Gly Glu Thr Asn Asp
545 550 555 560

Ser Tyr Ile Asp Pro His Leu Ala Gly Thr Asn Ala Gly Ile Ser Thr
565 570 575

Pro His Ser Thr Ala Trp Ala Val Leu Ala Gln Leu Ala Met Gly Glu
580 585 590

Val Glu Ser Asp Ser Val Arg Arg Gly Ile Ala Phe Leu Leu Ala Cys
595 600 605

Gln Gln Thr Asp Gly Leu Trp Ser His Pro Ser His Asn Ala Pro Gly
610 615 620

Phe Pro Arg Val Tyr Tyr Leu Lys Tyr His Gly Tyr Ala Ala Tyr Phe
625 630 635 640

Pro Leu Tyr Ala Leu Ala Arg Tyr Arg His Leu Leu Asn Arg Ser Arg
645 650 655

Glu Gln Arg


<210> 31
<211> 627
<212> PRT
<213> Bacillus amyloliquefaciens

<400> 31
Met Ser Thr Ile His Glu Asn Val Arg Ser Arg Gln Lys Lys Thr Ile
1 5 10 15

Ser Leu Leu Arg Glu Thr Gln Asn Ala Asp Gly Ser Trp Ser Phe Cys
20 25 30

Phe Glu Gly Pro Ile Leu Thr Asn Ala Phe Leu Ile Leu Leu Leu Thr
35 40 45

Ser Leu Gly Asp Asn Asp Lys Glu Leu Ile Ala Glu Leu Ala Glu Gly
50 55 60

Ile Arg Ala Lys Gln Arg Pro Asp Gly Thr Phe Ala Asn Tyr Pro Asp
65 70 75 80

Asp Arg Lys Gly Asn Val Thr Ala Thr Val Gln Gly Tyr Ala Gly Leu
85 90 95

Leu Ala Ser Gly Leu Tyr Ser Arg Ser Glu Ala His Met Ile Gln Ala
100 105 110

Glu Arg Phe Ile Ile Ser Asn Gly Gly Leu Arg Asn Val His Phe Met
115 120 125

Thr Lys Trp Met Leu Ala Ala Asn Gly Leu Tyr Pro Trp Pro Ala Leu
130 135 140

His Leu Pro Leu Ser Phe Leu Val Ile Pro Pro Thr Phe Pro Leu His
145 150 155 160

Phe Tyr Gln Phe Ser Thr Tyr Ala Arg Ile His Phe Val Pro Met Ala
165 170 175

Val Thr Leu Asn Lys Arg Phe Ser Leu Lys Asn Pro Asn Val Ser Ser
180 185 190

Leu Ala His Leu Asp Arg His Met Thr Lys Asn Pro Phe Thr Trp Leu
195 200 205

Arg Ser Asp Gln Asp Glu Asn Arg Asp Leu Ser Ser Leu Phe Ala His
210 215 220

Trp Lys Arg Leu Leu Gln Ile Pro Ala Ala Phe His Gln Leu Gly Leu
225 230 235 240

Arg Thr Ala Lys Thr Tyr Met Leu Asp Arg Ile Glu Glu Asp Gly Thr
245 250 255

Leu Tyr Ser Tyr Ala Ser Ala Thr Ile Phe Met Val Tyr Gly Leu Leu
260 265 270

Ala Leu Gly Val Ser Arg His Ser Pro Val Leu Arg Lys Ala Leu Ala
275 280 285

Gly Thr Lys Ala Leu Leu Thr Ser Cys Gly Asn Ile Pro Tyr Leu Glu
290 295 300

Asn Ser Thr Ser Thr Val Trp Asp Thr Ala Leu Leu Asn Tyr Ala Leu
305 310 315 320

Met Lys Ser Gly Ile Ser Asp Asn Asp Gln Met Ile Thr Ser Ala Ala
325 330 335

Arg Phe Leu Arg Glu Arg Gln Gln Lys Lys Val Ala Asp Trp Ala Val
340 345 350

His Asn Pro His Ala Glu Pro Gly Gly Trp Gly Phe Ser Asn Ile Asn
355 360 365

Thr Asn Asn Pro Asp Cys Asp Asp Thr Ala Ala Val Leu Lys Ala Ile
370 375 380

Pro Arg Lys Leu Tyr Pro Ala Ser Trp Glu Arg Gly Leu Ser Trp Leu
385 390 395 400

Leu Ser Met Gln Asn Ser Asp Gly Gly Phe Ser Ala Phe Glu Lys Asn
405 410 415

Val Asn His Pro Leu Val Arg Leu Leu Pro Leu Glu Ser Ala Glu Glu
420 425 430

Ala Ala Ile Asp Pro Ser Thr Ser Asp Leu Thr Gly Arg Val Leu His
435 440 445

Cys Leu Gly Glu Ala Gly Leu Ser Ser Asp His Pro Gln Ile Glu Lys
450 455 460

Ala Val Gln Trp Leu Ile Arg His Gln Glu Glu Asp Gly Ser Trp Tyr
465 470 475 480

Gly Arg Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr
485 490 495

Gly Met Lys Ala Cys Gly Val Ser Gln Asn His Pro Ala Val Lys Lys
500 505 510

Ala Ile Arg Trp Leu Lys Ser Ile Gln Asn Glu Asp Gly Ser Trp Gly
515 520 525

Glu Ser Cys Lys Ser Ala Glu Glu Lys Thr Tyr Val Pro Leu Ser Tyr
530 535 540

Gly Thr Leu Val Gln Thr Ala Trp Ala Ala Glu Ala Leu Leu Gln Tyr
545 550 555 560

Glu Lys Thr His His Gln Ala Val Thr Lys Gly Ile Ser Phe Leu Ile
565 570 575

Glu Asn Arg His Tyr Glu Gly Ala Ala Phe Ser Tyr Pro Thr Gly Ile
580 585 590

Gly Leu Pro Lys Gln Phe Tyr Ile Arg Tyr His Ser Tyr Pro Tyr Val
595 600 605

Phe Ser Leu Leu Ala Leu Ser Thr Phe Met Lys Met Ser Glu Lys Glu
610 615 620

Glu Glu Lys
625


<210> 32
<211> 617
<212> PRT
<213> Bacillus anthracis

<400> 32
Met Leu Leu Tyr Glu Lys Ala His Glu Glu Ile Val Arg Arg Ala Thr
1 5 10 15

Ala Leu Gln Thr Met Gln Trp Gln Asp Gly Thr Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu
35 40 45

Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Glu Arg Val Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu His Glu Asp Glu Val Gly
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Lys Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Asn Phe
100 105 110

Ile Gln Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Leu
130 135 140

Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Phe Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys
165 170 175

Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn
180 185 190

His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro
195 200 205

Val Phe Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile Ser Tyr Pro
210 215 220

Leu Ser Leu His His Lys Gly Tyr Glu Glu Ile Glu Arg Phe Met Lys
225 230 235 240

Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser
245 250 255

Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Leu Gln Ser
260 265 270

Ser Met Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr Ile Trp Lys
275 280 285

Met Glu Arg Gly Asn His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp
290 295 300

Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val Ser Lys Asp
305 310 315 320

Asn Lys Met Ile Gln Asn Ala Thr Ala Tyr Leu Leu Lys Lys Gln His
325 330 335

Thr Lys Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu Thr Pro Gly
340 345 350

Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp Asp
355 360 365

Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Lys Asn
370 375 380

Ile Asp Asn Ala Trp Lys Lys Gly Gly Asn Trp Ile Lys Gly Leu Gln
385 390 395 400

Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Lys
405 410 415

Leu Leu Ala Lys Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe Phe Gly Thr
435 440 445

Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Ile Gln Arg Ala Ile Asn
450 455 460

Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp
465 470 475 480

Gly Ile Cys Tyr Leu Tyr Gly Thr Trp Ala Val Met Thr Gly Leu Arg
485 490 495

Ser Leu Gly Ile Pro Ser Ser Asn Pro Ser Leu Thr Arg Ala Ala Ser
500 505 510

Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys
515 520 525

His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro
530 535 540

Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Asp Thr
545 550 555 560

Glu Thr Pro Ala Ile Arg Lys Gly Val Ser Tyr Leu Leu Ser Asn Pro
565 570 575

Tyr Val Asn Glu Arg Tyr Pro Thr Gly Thr Gly Leu Pro Gly Ala Phe
580 585 590

Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu Leu Thr Leu
595 600 605

Ala His Tyr Ile Lys Lys Tyr Arg Lys
610 615


<210> 33
<211> 631
<212> PRT
<213> Bacillus cereus

<400> 33
Met Asn Ile Val Ile Arg Ile Ser Lys Gly Trp Val Ser Asn Leu Leu
1 5 10 15

Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg Arg Thr Thr Ala Leu
20 25 30

Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Gln Phe Cys Phe Glu Gly
35 40 45

Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu Leu Gly
50 55 60

Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg Leu Ala Ser Leu Gln
65 70 75 80

Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly Gly Asn
85 90 95

Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser Lys Lys
100 105 110

Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Met Phe Ile Asn
115 120 125

Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe Leu Leu
130 135 140

Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Leu Pro Thr
145 150 155 160

Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu Ser Ile Phe Glu Leu
165 170 175

Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Val Cys Leu Asn
180 185 190

Lys Arg Phe Gln Val Gly Lys Lys Leu Leu Pro Asn Leu Asn His Ile
195 200 205

Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro Met Phe
210 215 220

Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile Ser Tyr Pro Leu Ser
225 230 235 240

Leu His His Lys Gly Tyr Glu Glu Val Glu Arg Phe Met Lys Glu Arg
245 250 255

Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser Phe Tyr
260 265 270

Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Leu Gln Ser Ser Met
275 280 285

Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr Ile Trp Lys Met Glu
290 295 300

Lys Gly Asn His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp Thr Ala
305 310 315 320

Leu Leu Ser Tyr Thr Leu Gln Glu Ala His Ala Ser Lys Asp Asn Lys
325 330 335

Met Ile Gln His Ala Ala Ala Tyr Val Leu Lys Lys Gln His Thr Lys
340 345 350

Lys Ala Asp Trp Ser Val His Ala Pro Gly Leu Ile Pro Gly Gly Trp
355 360 365

Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Val Asp Asp Thr Thr
370 375 380

Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Glu Asn Val Asp
385 390 395 400

Asn Ala Trp Lys Lys Gly Val Asn Trp Val Lys Gly Leu Gln Asn Asn
405 410 415

Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Asn Leu Leu
420 425 430

Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp Pro Ser
435 440 445

Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Leu Phe Gly Thr Tyr Ala
450 455 460

Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser Ala Ile Asn Trp Leu
465 470 475 480

Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp Gly Ile
485 490 495

Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr Gly Leu Arg Ser Leu
500 505 510

Gly Ile Pro Ser Ser Asn Pro Ser Met Lys Arg Ala Ala Leu Trp Leu
515 520 525

Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys Gln Ser
530 535 540

Ser Val Glu Lys Arg Phe Ile Thr Leu Pro Phe Ser Thr Pro Ser Gln
545 550 555 560

Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr His Asp Glu Glu Thr
565 570 575

Pro Ala Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ala Asn Pro Tyr Val
580 585 590

Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro Gly Gly Phe Tyr Ile
595 600 605

His Tyr His Ser Tyr Ala Tyr Ile Tyr Pro Leu Leu Thr Leu Ala His
610 615 620

Tyr Ile Lys Lys Tyr Arg Lys
625 630


<210> 34
<211> 631
<212> PRT
<213> Bacillus cereus

<400> 34
Met Asn Ile Val Ile Arg Ile Ser Lys Gly Trp Val Ser Asn Leu Leu
1 5 10 15

Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg Arg Thr Thr Ala Leu
20 25 30

Gln Ser Met Gln Arg Gln Asp Gly Thr Trp Arg Phe Cys Phe Glu Gly
35 40 45

Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu Leu Gly
50 55 60

Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg Leu Ala Ser Leu Gln
65 70 75 80

Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly Gly Asn
85 90 95

Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser Glu Lys
100 105 110

Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Met Phe Ile Asn
115 120 125

Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe Leu Leu
130 135 140

Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Leu Pro Thr
145 150 155 160

Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu Ser Ile Phe Glu Leu
165 170 175

Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys Leu Asn
180 185 190

Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn His Ile
195 200 205

Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro Val Phe
210 215 220

Gln Thr Leu Val Ser Asp Val Lys Lys Ile Ile Thr Tyr Pro Leu Ser
225 230 235 240

Leu His His Lys Gly Tyr Glu Glu Val Glu Arg Phe Met Lys Glu Arg
245 250 255

Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser Phe Tyr
260 265 270

Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Leu Gln Ser Ser Met
275 280 285

Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr Met Trp Lys Met Glu
290 295 300

Ser Gly Asn His Val Gln Asn Ser Pro Ser Thr Val Trp Asp Thr Ala
305 310 315 320

Leu Leu Ser Tyr Ala Leu Gln Glu Ala His Val Leu Lys Asp Asn Lys
325 330 335

Met Leu Gln Asn Ala Thr Ala Tyr Leu Leu Lys Lys Gln His Thr Lys
340 345 350

Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu Thr Pro Gly Gly Trp
355 360 365

Gly Phe Ser Asp Val Asn Thr Thr Val Pro Asp Val Asp Asp Thr Thr
370 375 380

Ala Val Leu Arg Val Leu Ala Arg Ser Arg Gly Asn Glu Lys Val Asp
385 390 395 400

His Ala Trp Gln Lys Gly Ile Asn Trp Val Lys Gly Leu Gln Asn Asn
405 410 415

Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser His Ile Leu
420 425 430

Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp Pro Ser
435 440 445

Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe Phe Gly Thr Tyr Ala
450 455 460

Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser Ala Ile Asn Trp Leu
465 470 475 480

Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp Gly Ile
485 490 495

Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr Gly Leu Arg Ser Leu
500 505 510

Gly Ile Pro Ser Ser Asp Pro Ser Leu Lys Arg Ala Ala Leu Trp Leu
515 520 525

Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys Gln Ser
530 535 540

Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro Ser Gln
545 550 555 560

Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Asp Lys Glu Thr
565 570 575

Ser Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ser Asn Pro Tyr Ile
580 585 590

Asn Glu Thr Tyr Pro Thr Gly Thr Gly Leu Pro Gly Gly Phe Tyr Ile
595 600 605

Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu Leu Thr Leu Ala His
610 615 620

Tyr Ala Lys Lys Tyr Arg Lys
625 630


<210> 35
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 35
Met Ser Asn Leu Leu Leu Tyr Glu Lys Ala His Glu Glu Ile Val Arg
1 5 10 15

Arg Ala Thr Ala Leu Gln Thr Met Gln Trp Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Glu Arg
50 55 60

Val Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Lys Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Asn Phe Ile Gln Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asp Asp Ala Pro Phe
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Val Phe Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Ile Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Leu Gln Ser Ser Met Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Asn His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val
305 310 315 320

Ser Lys Asp Asn Lys Met Ile Gln Asn Ala Thr Ala Tyr Leu Leu Lys
325 330 335

Lys Gln His Thr Lys Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu
340 345 350

Thr Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Lys Asn Ile Asp Asn Ala Trp Lys Lys Gly Gly Asn Trp Ile Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Lys Leu Leu Ala Lys Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Ile Gln Arg
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asn Pro Ser Leu Lys Arg
500 505 510

Ala Ala Ser Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Thr Glu Thr Pro Ala Ile Arg Lys Gly Val Ser Tyr Leu Leu
565 570 575

Leu Asn Pro Tyr Val Asn Glu Arg Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Ala Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Leu Lys Lys Tyr Arg Lys
610 615 620


<210> 36
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 36
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Ala Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Gln Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Asn Phe Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Val Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Val Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Leu Phe Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Leu Gln Ser Ser Met Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val
305 310 315 320

Pro Lys Asp His Lys Met Ile Gln Gln Thr Ile Thr Tyr Leu Leu Lys
325 330 335

Lys Gln His Thr Lys Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu
340 345 350

Thr Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Val Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Val Leu Arg Val Leu Ala Arg Ser Arg Glu
370 375 380

Asn Glu Lys Val Asn Asn Ala Trp Gln Lys Gly Ile Asp Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Lys Leu Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Leu
435 440 445

Phe Gly Thr Tyr Thr Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Ala Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Asn Asn Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Met Glu Lys Arg Phe Ile Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Thr Glu Thr Pro Ala Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Asn Pro Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala Gln Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Thr Lys Lys Tyr Arg Lys
610 615 620


<210> 37
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 37
Met Ser Asn Leu Leu Leu Tyr Glu Lys Ala His Glu Glu Ile Ala Arg
1 5 10 15

Arg Ala Thr Ala Leu Gln Thr Met Gln Arg Glu Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Gly Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Asn Phe Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Val Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Glu
195 200 205

Arg Ser Pro Leu Phe Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Leu Gln Ser Ser Met Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Ser Gly Asn His Val Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala His Val
305 310 315 320

Pro Lys Asp Asn Lys Met Leu Gln Asn Ala Thr Ala Tyr Leu Leu Lys
325 330 335

Lys Gln His Thr Lys Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu
340 345 350

Thr Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Val Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Val Leu Arg Val Leu Ala Arg Ser Lys Gly
370 375 380

Asn Glu Lys Leu Asp His Ala Trp Gln Lys Gly Ile Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Ala Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Phe Gly Ile Pro Ser Ser Asn Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Lys Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Thr Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Asn Pro Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Thr His Tyr Ile Lys Lys Tyr Arg Lys
610 615 620


<210> 38
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 38
Met Ser Asn Leu Leu Leu Tyr Glu Lys Ala His Glu Glu Ile Ala Arg
1 5 10 15

Arg Ala Thr Ala Leu Gln Ser Met Gln Trp Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Gly Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Asn Phe Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Val His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Glu
195 200 205

Arg Ser Pro Leu Phe Gln Thr Leu Val Ser Asp Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Leu Gln Ser Ser Ile Ile Gln Asn Ala Ile Thr Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Ser Gly Asn His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala His Val
305 310 315 320

Pro Lys Asp Asn Lys Met Leu Gln Asn Ala Thr Ala Tyr Leu Leu Lys
325 330 335

Lys Gln His Thr Lys Lys Ala Asp Trp Ser Val His Ala Ser Ala Leu
340 345 350

Thr Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Val Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Val Leu Arg Val Leu Ala Arg Ser Arg Gly
370 375 380

Asn Glu Lys Val Asp His Ala Trp Gln Lys Gly Ile Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Asn Ile Leu Ala Lys Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Phe Gly Ile Pro Ser Ser Asn Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Lys Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Thr Glu Thr Pro Ile Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Asn Pro Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ile Lys Lys Tyr Arg Lys
610 615 620


<210> 39
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 39
Met Asn Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Ala Thr Ala Leu Gln Thr Met Gln Gln Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Lys Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Asn Phe Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser His Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Ser Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Leu Phe Gln Thr Leu Val Ser Asp Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Leu Gln Ser Thr Met Ile Gln Lys Ala Ile Thr Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Ser Gly Asn His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala His Val
305 310 315 320

Pro Lys Asp Asn Lys Met Ile Gln His Ala Ala Thr Tyr Leu Leu Lys
325 330 335

Lys Gln His Thr Gln Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu
340 345 350

Thr Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Glu Lys Val Asp Asn Ala Trp Pro Lys Gly Ile Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Asn Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Lys Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asn Pro Ser Met Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Ser Ile Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Asn Pro Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ile Lys Lys Tyr Arg Lys
610 615 620


<210> 40
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 40
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Arg Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Lys Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Met Phe Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Val His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Ser Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Lys Phe Arg Ile Arg Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ser Gly Gly Gly Gly Glu Trp Phe Arg Gly Asn
195 200 205

Arg Ser Pro Leu Phe Gln Thr Leu Val Ser Asp Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Asn Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Leu Gln Ser Thr Met Ile Gln Lys Ala Ile Thr Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Asn Met Glu Ser Gly Asn His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala His Val
305 310 315 320

Pro Lys Asp Thr Asn Met Leu Gln His Ala Thr Ala Tyr Leu Leu Lys
325 330 335

Lys Gln His Thr Lys Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu
340 345 350

Ala Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Ser Glu Lys Val Asp Tyr Val Trp Glu Lys Gly Ile Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Asn Leu Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Leu
435 440 445

Phe Gly Thr Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Thr Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Lys Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asn Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Pro Ala Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Asn Arg Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Cys Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ile Lys Lys Tyr Arg Lys
610 615 620


<210> 41
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 41
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Gln
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Met Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Met Phe Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Val Phe Gln Thr Leu Val Ser Asp Val Lys Lys Ile Ile
210 215 220

Thr Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Gln Lys Ala Ile Thr Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Val Leu Gln Glu Ala Gln Val
305 310 315 320

Pro Lys Ala Ser Lys Val Ile His Asn Ala Ser Ala Tyr Leu Leu Arg
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asp Leu
340 345 350

Phe Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Glu Asn Val Asp Thr Ala Trp Lys Arg Ala Val Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Thr Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Thr Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asp Pro Ser Val Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ser Asn Ser Tyr Ile Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ala Lys Lys Tyr Arg Lys
610 615 620


<210> 42
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 42
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Met Phe Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Val Phe Gln Thr Leu Val Ser Asp Val Lys Lys Ile Ile
210 215 220

Thr Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Glu Lys Ala Ile Met Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Val Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Ile Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val
305 310 315 320

Pro Lys Ala Ser Lys Val Ile Gln Asn Ala Ser Ala Tyr Leu Leu Arg
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asp Leu
340 345 350

Phe Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Glu His Val Asp Asn Ala Trp Lys Arg Ala Val Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Thr Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asp Ser Ser Leu Lys Arg
500 505 510

Ala Val Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ser Asn Pro Tyr Ile Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ala Lys Lys Tyr Arg Lys
610 615 620


<210> 43
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 43
Met Asn Ala Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Val Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Asp Asp
65 70 75 80

Glu Met Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Lys Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Met Phe Ile Thr Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Gln Ser Pro Met Phe Gln Thr Leu Leu Gly Asn Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Asn Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Ser Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Met Ile Gln Lys Ala Ile Thr Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Asn His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Arg Val
305 310 315 320

Ser Lys Glu Ser Lys Met Ile Gln Asn Ala Ser Ala Tyr Leu Leu Lys
325 330 335

Lys Gln His Lys Lys Lys Ala Asp Trp Ser Val His Ala Pro Val Leu
340 345 350

Ile Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Val Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Gln Ser Arg Gly
370 375 380

Asn Gly Asn Val Asp Asp Ala Trp Lys Lys Gly Thr Asn Trp Ile Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Lys Leu Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Thr Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Glu Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ala Leu Gly Ile Thr Ser Ala His Pro Ser Leu Lys Arg
500 505 510

Ala Thr Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Arg Phe Ala Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Pro Ala Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Asn Pro Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Ala Leu Pro
580 585 590

Gly Gly Phe Tyr Ile His Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ala Lys Lys Tyr Lys Lys
610 615 620


<210> 44
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 44
Met Ser Gly Val Leu Leu Tyr Asp Lys Val His Glu Glu Ile Glu Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Gln
20 25 30

Phe Cys Phe Glu Gly Ala Leu Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asn Asp Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Lys Gly Gly Asn Leu Ser Ala Thr Ile Gln Ala Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Ser Lys Glu Asp Met Asn Met Arg Arg Ala
100 105 110

Glu Met Phe Ile Lys Glu His Gly Gly Val Ser Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Phe Pro Ala Leu
130 135 140

Phe His Phe Pro Thr Pro Ile Leu Phe Leu Gln Asp Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Gly Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Ile Cys Met Asn Lys Arg Phe Arg Val Glu Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Gln Trp Phe Arg Glu Glu
195 200 205

Arg Ser Pro Leu Phe Gln Ser Leu Leu Gly Asp Val Lys Lys Val Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Ser Ala Thr Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Glu Lys Ala Val Thr Gly Leu Lys Ser Tyr
275 280 285

Ile Trp Lys Met Asp Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ser Leu Gln Glu Ala Lys Val
305 310 315 320

Thr Asn Glu Asn Lys Met Ile Gln Arg Ala Thr Glu Tyr Leu Leu Gln
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Ser Ser Leu
340 345 350

Val Ala Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Asp Arg Val Asp Asp Ala Trp Gly Arg Gly Val Glu Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Arg Gly Val
405 410 415

Thr Ser Lys Leu Leu Ser Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Leu
435 440 445

Phe Gly Thr Tyr Ala Pro Asn Glu Leu Leu Glu Glu Gln Lys Lys Lys
450 455 460

Ala Ile Lys Trp Leu Met Asp Val Gln Glu Gln Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Thr Met Thr
485 490 495

Gly Leu Arg Ala Leu Gly Val Pro Ser Thr His Pro Ser Leu Lys Lys
500 505 510

Ala Ala Ser Trp Leu Glu His Leu Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Lys Phe Ile Ser Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Gln Glu Thr Pro Ile Ile Arg Lys Gly Ile Thr Tyr Leu Leu
565 570 575

Ala Gln Ser Thr Met Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Gly His Ile Tyr Pro Leu
595 600 605

Leu Ala Leu Ala His Tyr Val Lys Lys Tyr Arg Lys
610 615 620


<210> 45
<211> 620
<212> PRT
<213> Bacillus cereus

<400> 45
Met Ser Gly Val Leu Leu Tyr Asp Lys Val Arg Glu Glu Ile Glu Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Ser
20 25 30

Phe Cys Phe Glu Gly Ala Leu Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asn Asp Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Asn Gly Gly Asn Leu Ser Ala Thr Ile Gln Ala Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Ser Lys Glu Asp Ile Asn Met Arg Arg Ala
100 105 110

Glu Met Phe Ile Lys Glu His Gly Gly Val Ser Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Phe Pro Thr Leu
130 135 140

Phe His Phe Pro Thr Pro Ile Leu Phe Leu Gln Asp Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Ile Cys Met Asn Lys Arg Phe Arg Val Glu Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Glu Gly Gly Gln Trp Phe Arg Glu Glu
195 200 205

Arg Ser Pro Leu Phe Gln Ser Phe Val Gly Asp Val Lys Lys Val Ile
210 215 220

Ala Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Ile Gly Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Ser Ala Thr Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Glu Lys Ala Val Ile Gly Leu Lys Ser Tyr
275 280 285

Ile Trp Lys Met Asp Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ser Leu Gln Glu Ala Asn Val
305 310 315 320

Met Lys Glu Asn Lys Met Ile Gln Lys Ala Thr Glu Tyr Leu Leu Gln
325 330 335

Arg Gln Gln Thr Lys Arg Met Asp Trp Ser Val His Ala Pro Ser Ile
340 345 350

Met Ala Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Ser Ser Arg Val Asp Ser Ala Trp Glu Arg Gly Val Glu Trp Leu Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Arg Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Ala Pro Asn Glu Leu Pro Glu Glu Gln Lys Lys Lys
450 455 460

Ala Val Lys Trp Leu Met Asp Val Gln Glu Leu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Met Thr
485 490 495

Gly Leu Arg Ala Leu Gly Val Pro Ser Ser His Pro Ser Leu Lys Lys
500 505 510

Ala Ala Ser Trp Leu Glu His Leu Gln Tyr Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Lys Phe Ile Ser Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Gln Glu Thr Pro Ile Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Gln Pro Thr Met Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Gly His Ile Tyr Pro Leu
595 600 605

Leu Ala Leu Ala His Tyr Ile Lys Lys Tyr Lys Lys
610 615 620


<210> 46
<211> 619
<212> PRT
<213> Bacillus cereus

<400> 46
Met Leu Leu Tyr Glu Lys Val His Glu Glu Val Lys Glu Lys Met Ala
1 5 10 15

Ala Leu Gln Ala Met Gln Gln Gln Asp Gly Thr Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ser Pro Leu Thr Asp Cys Tyr Met Ile Phe Leu Leu Thr Leu
35 40 45

Leu Gly Gln Asp Gln Glu Ile Glu Pro Phe Val Ala Arg Leu Ala Ala
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Pro Asp
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ala Tyr Ala Ala Leu Leu Val Ser
85 90 95

Lys Met Tyr Lys Lys Glu Asp Ile Asn Met Lys Arg Ala Glu Val Phe
100 105 110

Ile Arg Lys Gln Gly Gly Ile Thr Lys Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Leu His Gly Gly Tyr Glu Tyr Pro Pro Leu Phe His Phe
130 135 140

Pro Thr Pro Ile Leu Phe Leu Ser Glu Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys
165 170 175

Met Asn Lys Arg Phe Thr Val Ser Lys Lys Met Leu Pro Asn Leu Asp
180 185 190

Tyr Ile Ser Gly Gly Ser Lys Glu Gln Trp Phe Arg Glu Glu Arg Ser
195 200 205

Pro Leu Phe Gln Thr Leu Leu Arg Asp Val Thr Lys Phe Leu Ser Tyr
210 215 220

Pro Leu Ser Leu His Tyr Lys Gly Asp Lys Ala Ala Glu Arg Phe Met
225 230 235 240

Ile Glu Arg Ile Asp Thr Asn Gly Thr Leu Tyr Ser Tyr Ala Ser Ala
245 250 255

Thr Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Ile Gln
260 265 270

Ser Pro Leu Ile Ser Asn Ala Val Leu Gly Leu Lys Thr Tyr Val Trp
275 280 285

Asn Met Asp Arg Trp Ala His Leu Gln Asn Ser Pro Ser Thr Val Trp
290 295 300

Asp Thr Ala Leu Leu Ser Tyr Ser Leu Gln Glu Ala Arg Val Pro His
305 310 315 320

Asp Asn Glu Met Ile Gln Lys Ala Ile Asn Tyr Leu Leu Gln Lys Gln
325 330 335

His Lys Glu Lys Lys Asp Trp Ser Val His Ala Pro Thr Leu Asp Ala
340 345 350

Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Val Asp
355 360 365

Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Gly Ser Arg Gln Gly Asn
370 375 380

Pro Lys Val Glu Ser Ala Trp Arg Lys Gly Ile Glu Trp Val Lys Gly
385 390 395 400

Leu Gln Asn Ser Asp Gly Gly Trp Ala Ala Phe Glu Lys Gly Val Thr
405 410 415

Ser Lys Val Leu Thr His Leu Pro Leu Asp Asn Ser Gly Asp Met Ile
420 425 430

Thr Asp Pro Ser Thr Val Asp Ile Thr Gly Arg Val Leu Glu Phe Phe
435 440 445

Gly Thr Tyr Ala Pro Asn Glu Leu Gln Gly Asp Gln Lys Asp Arg Ala
450 455 460

Ile Arg Trp Leu Ile Tyr Thr Gln Glu Lys Asn Gly Ser Trp His Gly
465 470 475 480

Lys Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr Gly
485 490 495

Leu Arg Ala Val Gly Val Pro Ser Asn His Ile Ala Leu Gln Lys Ala
500 505 510

Ala Thr Trp Leu Glu Ser Ile Gln His Ser Asp Gly Gly Trp Gly Glu
515 520 525

Ser Cys Arg Ser Ser Val Glu Lys Lys Phe Ile Ser Leu Pro Phe Ser
530 535 540

Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ala Cys Tyr
545 550 555 560

Asp Ser Glu Thr Pro Thr Ile Arg Lys Gly Ile Ser Tyr Leu Leu Lys
565 570 575

His Ser Thr Lys His Gln Glu Tyr Pro Thr Gly Thr Ala Leu Ala Asn
580 585 590

Gly Phe Tyr Ile Arg Tyr His Ser Tyr His His Ile Phe Pro Leu Leu
595 600 605

Thr Phe Ala His Tyr Ile Lys Lys Tyr Arg Lys
610 615


<210> 47
<211> 617
<212> PRT
<213> Bacillus cereus

<400> 47
Met Leu Leu Tyr Glu Lys Val His Glu Glu Ile Val Arg Arg Ala Thr
1 5 10 15

Ala Leu Gln Thr Met Gln Trp Gln Asp Gly Thr Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu
35 40 45

Leu Gly Arg Glu Lys Glu Ile Glu Pro Phe Val Glu Arg Ile Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Lys Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Asn Phe
100 105 110

Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Ile His Gly Gly Tyr Glu Tyr Pro Ser Leu Phe His Leu
130 135 140

Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys
165 170 175

Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn
180 185 190

His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro
195 200 205

Val Phe Gln Thr Leu Ile Ser Asp Val Lys Gln Ile Ile Ser Tyr Pro
210 215 220

Leu Ser Leu His His Lys Gly Tyr Glu Glu Ile Glu Arg Phe Met Lys
225 230 235 240

Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser
245 250 255

Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Pro Gln Ser
260 265 270

Ser Met Ile Gln Lys Ala Ile Ala Gly Leu Thr Ser Tyr Ile Trp Lys
275 280 285

Met Gly Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp
290 295 300

Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Arg Val Ser Lys Asp
305 310 315 320

Asn Lys Met Ile Gln Asn Ala Thr Ala Tyr Leu Leu Lys Lys Gln His
325 330 335

Thr Lys Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu Ile Pro Gly
340 345 350

Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp Asp
355 360 365

Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Lys Asn
370 375 380

Ile Asp Asn Ala Trp Gln Lys Gly Val Asn Trp Ile Lys Gly Leu Gln
385 390 395 400

Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Lys
405 410 415

Leu Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe Phe Gly Thr
435 440 445

Tyr Ala Gln Asn Gly Leu Pro Glu Lys Gln Lys Gln Ser Ala Ile Asn
450 455 460

Trp Leu Met Asn Ala Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp
465 470 475 480

Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr Gly Leu Arg
485 490 495

Ser Leu Gly Ile Pro Ser Ser Asn Pro Ser Leu Lys Arg Ala Ala Ser
500 505 510

Trp Leu Glu Tyr Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys
515 520 525

His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro
530 535 540

Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Asp Thr
545 550 555 560

Glu Thr Pro Ala Ile Arg Lys Gly Val Ser Tyr Leu Leu Ser Asn Pro
565 570 575

Tyr Val Asn Glu Arg Tyr Pro Thr Gly Thr Gly Leu Pro Gly Ala Phe
580 585 590

Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu Leu Thr Leu
595 600 605

Ala His Tyr Leu Lys Lys Tyr Arg Lys
610 615


<210> 48
<211> 617
<212> PRT
<213> Bacillus cereus

<400> 48
Met Leu Leu Tyr Glu Lys Ala His Glu Glu Ile Ala Arg Arg Ala Thr
1 5 10 15

Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu
35 40 45

Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg Leu Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Lys Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Asn Phe
100 105 110

Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Leu
130 135 140

Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Val Cys
165 170 175

Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn
180 185 190

His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro
195 200 205

Leu Phe Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile Ser Tyr Pro
210 215 220

Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg Phe Met Lys
225 230 235 240

Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser
245 250 255

Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Leu Gln Ser
260 265 270

Ser Leu Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr Ile Trp Lys
275 280 285

Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp
290 295 300

Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala His Val Pro Lys Asp
305 310 315 320

His Lys Met Ile Gln Gln Thr Ile Thr Tyr Leu Leu Lys Lys Gln His
325 330 335

Thr Lys Lys Ala Asp Trp Ser Val His Ala Leu Ala Leu Thr Pro Gly
340 345 350

Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Val Asp Asp
355 360 365

Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Glu Asn
370 375 380

Ile Asp Asn Ala Trp Lys Lys Gly Val Asn Trp Ile Lys Gly Leu Gln
385 390 395 400

Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Lys
405 410 415

Leu Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Leu Phe Gly Thr
435 440 445

Tyr Thr Gln Asn Glu Leu Pro Lys Lys Gln Lys Gln Ser Ala Ile Asn
450 455 460

Trp Leu Met Asn Val Gln Glu Arg Asn Gly Ser Trp Tyr Gly Lys Trp
465 470 475 480

Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr Gly Leu Arg
485 490 495

Ser Leu Gly Ile Pro Ser Asn Asn Pro Ser Leu Lys Arg Ala Ala Leu
500 505 510

Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys
515 520 525

Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro
530 535 540

Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Asp Lys
545 550 555 560

Glu Thr Pro Thr Ile Arg Lys Gly Val Ser Tyr Leu Leu Ala Asn Pro
565 570 575

Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro Gly Gly Phe
580 585 590

Tyr Ile Arg Tyr His Ser Tyr Ala Gln Ile Tyr Pro Leu Leu Thr Leu
595 600 605

Ala His Tyr Thr Lys Lys Tyr Gln Lys
610 615


<210> 49
<211> 617
<212> PRT
<213> Bacillus cereus

<400> 49
Met Leu Leu Tyr Glu Lys Val Tyr Glu Glu Ile Ala Arg Arg Thr Thr
1 5 10 15

Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu
35 40 45

Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg Leu Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Met Phe
100 105 110

Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Leu
130 135 140

Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys
165 170 175

Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn
180 185 190

His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro
195 200 205

Val Phe Gln Thr Leu Leu Ser Glu Val Lys Lys Ile Ile Thr Tyr Pro
210 215 220

Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg Phe Met Lys
225 230 235 240

Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser
245 250 255

Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Ile Gln Ser
260 265 270

Pro Ile Ile Gln Lys Ala Ile Thr Gly Ile Ala Ser Tyr Ile Trp Lys
275 280 285

Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp
290 295 300

Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val Pro Lys Ala
305 310 315 320

Ser Lys Val Ile Gln Asn Ala Ser Ala Tyr Leu Leu Arg Lys Gln Gln
325 330 335

Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asn Leu Phe Pro Gly
340 345 350

Gly Trp Gly Phe Ser Asp Val Asn Thr Met Ile Pro Asp Ile Asp Asp
355 360 365

Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly Asp Glu Asn
370 375 380

Val Asp Asn Ala Trp Lys Arg Ala Val Asn Trp Val Lys Gly Leu Gln
385 390 395 400

Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Arg
405 410 415

Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe Phe Gly Thr
435 440 445

Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser Ala Ile Asn
450 455 460

Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp
465 470 475 480

Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr Gly Leu Arg
485 490 495

Ser Leu Gly Ile Pro Ser Ser Asp Pro Ser Leu Lys Arg Ala Ala Leu
500 505 510

Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys
515 520 525

Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro
530 535 540

Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Glu Lys
545 550 555 560

Glu Thr Pro Ile Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ser Asn Pro
565 570 575

Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro Gly Gly Phe
580 585 590

Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu Leu Thr Leu
595 600 605

Ala His Tyr Thr Lys Lys Tyr Arg Lys
610 615


<210> 50
<211> 486
<212> PRT
<213> Bacillus coahuilensis

<400> 50
Met Ala Glu Ala Ile Ser Tyr Pro Arg Arg Val His Ile Ile Thr Thr
1 5 10 15

Lys Phe Pro Val Asn Phe Tyr Asp Phe Ser Val Phe Gly Arg Ser Asn
20 25 30

Ile Ala Pro Ile Leu Leu Leu Ala Asp Ser Lys Phe Gln Ile Pro Lys
35 40 45

Thr Thr Glu Thr Pro Asp Ile Ser His Leu Tyr Val Arg Glu Leu Tyr
50 55 60

Trp Trp Ser Glu Asp Arg Gly Trp Asn Gly Phe Thr Lys Ala Ile Asn
65 70 75 80

Lys Gly Val Asn Asn Leu Ile Gly Leu Pro Asn Glu Leu His Thr Leu
85 90 95

Gly Arg Lys Gln Ala Glu Asn Tyr Met Leu Asp Arg Leu Glu Asp Asp
100 105 110

Gly Thr Leu Leu Ser Tyr Tyr Ser Ser Thr Phe Phe Met Ile Tyr Ala
115 120 125

Leu Leu Ser Val Gly Tyr Thr Lys Asp His Lys Val Ile Lys Lys Ala
130 135 140

Ala Arg Gly Leu Leu Ser Met Asn Thr Thr Val Lys Asp Thr Ile His
145 150 155 160

Ile Gln Tyr Thr Thr Ala His Ile Trp Asn Thr Ser Leu Ile Ser His
165 170 175

Ala Leu Gln Thr Ala Gly Ala Ser Pro Asp Asp Thr Met Val Met Arg
180 185 190

Ala Asn His Tyr Leu Leu Gln Arg Gln His Thr Lys Phe Gly Asp Trp
195 200 205

Ala Ile Tyr Gln Pro Asn Leu Gly Pro Gly Gly Trp Gly Phe Ser His
210 215 220

Ser Asn Thr Phe Asn Pro Asp Val Asp Asp Thr Thr Ala Ser Leu Arg
225 230 235 240

Ser Ile Gln Asn Ser Leu His Ser His Pro Asn Tyr Gln Ser Ser Trp
245 250 255

Tyr Arg Gly Leu Ser Phe Thr Leu Gly Met Gln Asn Gln Asp Gly Gly
260 265 270

Phe Pro Ala Phe Glu Lys Gly Val Asp Lys Thr Phe Leu His Leu Leu
275 280 285

Pro Val Gln Gly Ala Glu Phe Leu Leu Thr Asp Pro Ser Thr Pro Asp
290 295 300

Leu Thr Gly Arg Thr Leu Glu Phe Leu Gly Glu Ser Ala His Leu Tyr
305 310 315 320

Lys Asp Ser Gly Ala Ile Lys Arg Gly Val Asn Trp Leu Ile Glu Asn
325 330 335

Gln Arg Arg Asp Gly Ser Trp Tyr Gly Arg Trp Gly Ile Cys Tyr Ile
340 345 350

Tyr Gly Thr Trp Ala Ala Leu Thr Gly Leu Gln Ala Val Gly Val Ser
355 360 365

Lys Glu His Pro Ser Val Gln Glu Gly Ile Asp Trp Leu Lys Ser Ile
370 375 380

Gln Gln Asp Asp Gly Gly Trp Gly Glu Ser Cys Glu Ser Asp Ser Gln
385 390 395 400

Lys Thr Tyr Ile Pro Leu Ser Lys Ser Thr Val Thr Gln Thr Ala Trp
405 410 415

Ala Val Asp Ala Leu Ile Ala Tyr Glu Lys Glu Glu Thr Val Glu Ile
420 425 430

Lys Lys Gly Met Glu Tyr Leu Leu Glu Asn Trp Asn His Glu Asp Trp
435 440 445

Thr Met Asp Tyr Pro Met Gly Gln Gly Met Ala Lys Ala Phe Tyr Ile
450 455 460

His Tyr His Ser Tyr Arg Tyr Val Phe Pro Leu Leu Thr Met Gly His
465 470 475 480

Tyr Met Arg Lys Phe Met
485


<210> 51
<211> 619
<212> PRT
<213> Bacillus cytotoxicus

<400> 51
Met Val Leu Tyr Gly Arg Val Cys Ala Glu Ile Glu Arg Thr Ile Thr
1 5 10 15

Ala Leu His Thr Met Gln Gln Gln Asp Gly Ala Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ser Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Arg Leu
35 40 45

Leu Glu Lys Glu Glu Glu Ile Glu Pro Phe Val Ala Arg Leu Thr Ser
50 55 60

Ile Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Arg Ala
65 70 75 80

Gly Asn Val Ser Thr Thr Ile Gln Ala Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Gly Met Tyr Thr Lys Glu Asp Val Asn Met Lys Arg Ala Glu Ala Phe
100 105 110

Ile Gln Glu Arg Gly Gly Ile Ala Arg Ser His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Leu His Gly Gly Tyr Glu Tyr Pro Arg Met Phe Tyr Phe
130 135 140

Pro Thr Pro Ile Leu Phe Leu Pro Glu Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Ile Cys
165 170 175

Met Asn Lys Arg Phe Thr Val Ser Lys Thr Ile Leu Pro Asn Leu Asp
180 185 190

His Ile Ser Gly Ser Ser Lys Ser Glu Trp Phe Arg Glu Asp Arg Ser
195 200 205

Ser Leu Phe Glu Thr Ile Leu Gly Glu Val Lys Lys Phe Val Thr Tyr
210 215 220

Pro Leu Ser Leu His His Lys Gly Asp Lys Glu Ala Glu Arg Phe Met
225 230 235 240

Ile Glu Arg Ile Asp Arg Asn Gly Thr Leu Tyr Ser Tyr Ala Ser Ala
245 250 255

Thr Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His His Ile Gln
260 265 270

Ser Pro Leu Ile Gln Gln Ala Val Ala Gly Leu Arg Thr Tyr Lys Trp
275 280 285

His Met Glu Ala Gly Ile His Leu Gln Asn Ser Pro Ser Thr Val Trp
290 295 300

Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Asn Val Asn Glu
305 310 315 320

Ser Thr Pro Met Ile Gln Thr Ala Thr Glu Tyr Ile Trp Gln Arg Gln
325 330 335

His His Glu Lys Lys Asp Trp Ser Leu His Ala Pro Thr Leu Ser Pro
340 345 350

Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Val Asp
355 360 365

Asp Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Lys Arg Asn
370 375 380

Arg Arg Ile Glu Glu Ala Trp Lys Lys Gly Val Asn Trp Val Lys Gly
385 390 395 400

Leu Gln Asn Lys Asp Gly Gly Trp Ala Ala Phe Glu Lys Gly Val Thr
405 410 415

Asn Arg Phe Leu Thr His Leu Pro Leu Glu Asn Ser Gly Asp Met Met
420 425 430

Thr Asp Pro Ser Thr Ala Asp Ile Thr Gly Arg Val Leu Glu Phe Phe
435 440 445

Gly Thr Tyr Ala Pro Asn Glu Leu Gln Asp His Gln Lys Asn Arg Ala
450 455 460

Ile Thr Trp Leu Met Asp Val Gln Glu Asn Asn Gly Ser Trp Tyr Gly
465 470 475 480

Lys Trp Gly Val Ser Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr Gly
485 490 495

Leu Arg Ala Val Gly Val Ala Asn Thr His Pro Ala Leu Lys Lys Ala
500 505 510

Val Met Trp Leu Glu Arg Ile Gln His Arg Asp Gly Gly Trp Gly Glu
515 520 525

Ser Cys Arg Ser Ser Ile Glu Lys Arg Phe Val Pro Leu Ser Phe Ser
530 535 540

Thr Pro Ser Gln Thr Ala Trp Ala Ile Asp Ala Leu Ile Ser Tyr Tyr
545 550 555 560

Asp Glu Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu Glu
565 570 575

His Ala Ala Ser His Gln Glu Tyr Pro Thr Gly Thr Gly Leu Pro Asn
580 585 590

Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ser Tyr Met Tyr Pro Leu Leu
595 600 605

Thr Phe Ala His Tyr Ile Asn Lys Tyr Arg Lys
610 615


<210> 52
<211> 629
<212> PRT
<213> Bacillus licheniformis

<400> 52
Met Arg Ser Ile Leu Glu Asp Val Lys Ala Phe Arg Gln Lys Thr Leu
1 5 10 15

Ala Glu Leu Gln Asn Arg Gln Arg Ser Asp Gly Ser Trp Arg Phe Cys
20 25 30

Phe Glu Gly Pro Val Met Thr Asp Ser Phe Phe Ile Leu Met Leu Thr
35 40 45

Ser Leu Gly Asp Gln Asp Ser Ser Leu Ile Ala Ser Leu Ala Glu Arg
50 55 60

Ile Arg Ser Arg Gln Ser Glu Asp Gly Ala Phe Arg Asn His Pro Asp
65 70 75 80

Glu Arg Ala Gly Asn Leu Thr Ala Thr Val Gln Gly Tyr Thr Gly Met
85 90 95

Leu Ala Ser Gly Leu Tyr Asp Arg Lys Ala Pro His Met Gln Lys Ala
100 105 110

Glu Ala Phe Ile Lys Asp Ala Gly Gly Leu Lys Gly Val His Phe Met
115 120 125

Thr Lys Trp Met Leu Ala Ala Asn Gly Leu Tyr Pro Trp Pro Arg Ala
130 135 140

Tyr Ile Pro Leu Ser Phe Leu Leu Ile Pro Ser Tyr Phe Pro Leu His
145 150 155 160

Phe Tyr His Phe Ser Thr Tyr Ala Arg Ile His Phe Val Pro Met Ala
165 170 175

Ile Thr Phe Asn Arg Arg Phe Ser Leu Lys Asn Asn Gln Ile Gly Ser
180 185 190

Leu Arg His Leu Asp Glu Ala Met Ser Lys Asn Pro Leu Glu Trp Leu
195 200 205

Asn Ile Arg Ala Phe Asp Glu Arg Thr Phe Tyr Ser Phe Asn Leu Gln
210 215 220

Trp Lys Gln Leu Phe Gln Trp Pro Ala Tyr Val His Gln Leu Gly Phe
225 230 235 240

Glu Ala Gly Lys Lys Tyr Met Leu Asp Arg Ile Glu Glu Asp Gly Thr
245 250 255

Leu Tyr Ser Tyr Ala Ser Ala Thr Met Phe Met Ile Tyr Ser Leu Leu
260 265 270

Ala Met Gly Ile Ser Lys Asn Ala Pro Val Val Lys Lys Ala Val Ser
275 280 285

Gly Ile Lys Ser Leu Ile Ser Ser Cys Gly Lys Glu Gly Ala His Leu
290 295 300

Glu Asn Ser Thr Ser Thr Val Trp Asp Thr Ala Leu Ile Ser Tyr Ala
305 310 315 320

Met Gln Glu Ser Gly Val Pro Glu Gln His Ser Ser Thr Ser Ser Ala
325 330 335

Ala Asp Tyr Leu Leu Lys Arg Gln His Val Lys Lys Ala Asp Trp Ala
340 345 350

Val Ser Asn Pro Gln Ala Val Pro Gly Gly Trp Gly Phe Ser His Ile
355 360 365

Asn Thr Asn Asn Pro Asp Leu Asp Asp Thr Ala Ala Ala Leu Lys Ala
370 375 380

Ile Pro Phe Gln Arg Arg Pro Asp Ala Trp Asn Arg Gly Leu Ala Trp
385 390 395 400

Leu Leu Ser Met Gln Asn Lys Asp Gly Gly Phe Ala Ala Phe Glu Lys
405 410 415

Asp Val Asp His Pro Leu Ile Arg Asn Leu Pro Leu Glu Ser Ala Ala
420 425 430

Glu Ala Ala Val Asp Pro Ser Thr Ala Asp Leu Thr Gly Arg Val Leu
435 440 445

His Leu Leu Gly Leu Lys Gly Arg Phe Thr Asp Asn His Pro Ala Val
450 455 460

Arg Arg Ala Leu Arg Trp Leu Asp His His Gln Lys Ala Asp Gly Ser
465 470 475 480

Trp Tyr Gly Arg Trp Gly Val Cys Phe Ile Tyr Gly Thr Trp Ala Ala
485 490 495

Leu Thr Gly Met Lys Ala Val Gly Val Ser Ala Asn Gln Thr Ser Val
500 505 510

Lys Lys Ala Ile Ser Trp Leu Lys Ser Ile Gln Arg Glu Asp Gly Ser
515 520 525

Trp Gly Glu Ser Cys Lys Ser Cys Glu Ala Lys Arg Phe Val Pro Leu
530 535 540

His Phe Gly Thr Val Val Gln Ser Ser Trp Ala Leu Glu Ala Leu Leu
545 550 555 560

Gln Tyr Glu Arg Pro Asp Asp Pro Gln Ile Ile Lys Gly Ile Arg Phe
565 570 575

Leu Ile Asp Glu His Glu Ser Ser Arg Glu Arg Leu Glu Tyr Pro Thr
580 585 590

Gly Ile Gly Leu Pro Asn Gln Phe Tyr Ile Arg Tyr His Ser Tyr Pro
595 600 605

Phe Val Phe Ser Leu Leu Ala Ser Ser Ala Phe Ile Lys Lys Ala Glu
610 615 620

Met Arg Glu Thr Tyr
625


<210> 53
<211> 620
<212> PRT
<213> Bacillus mycoides

<400> 53
Met Ser Gly Val Leu Leu Tyr Asp Lys Val His Glu Glu Ile Glu Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Gln
20 25 30

Phe Cys Phe Glu Gly Ala Leu Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asn Asp Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Val Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Lys Gly Gly Asn Leu Ser Ala Thr Ile Gln Ala Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Arg Tyr Ser Lys Glu Ala Met Asn Met Arg Arg Ala
100 105 110

Glu Met Phe Ile Lys Glu His Gly Gly Val Ser Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Phe Pro Ala Leu
130 135 140

Phe His Phe Pro Thr Pro Ile Leu Phe Leu Gln Asp Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Gly Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Ile Cys Met Asn Lys Arg Phe Arg Val Glu Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Gln Trp Phe Arg Glu Glu
195 200 205

Arg Ser Pro Leu Phe Gln Ser Phe Leu Gly Asp Val Lys Lys Val Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Ser Ala Thr Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Glu Lys Ala Val Thr Gly Leu Lys Ser Tyr
275 280 285

Ile Trp Lys Met Asp Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ser Leu Gln Glu Ala Lys Val
305 310 315 320

Thr Asn Glu Asn Lys Met Ile Gln Arg Ala Thr Glu Tyr Leu Leu Gln
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Ser Ser Leu
340 345 350

Val Ala Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Asp Arg Val Asp Asp Ala Trp Gly Arg Gly Val Glu Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Arg Gly Val
405 410 415

Thr Ser Lys Leu Leu Ser Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Leu
435 440 445

Phe Gly Thr Tyr Ala Pro Asn Glu Leu Leu Glu Glu Gln Lys Lys Lys
450 455 460

Ala Ile Lys Trp Leu Met Asp Val Gln Glu Gln Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Thr Met Thr
485 490 495

Gly Leu Arg Ala Leu Gly Val Pro Ser Thr His Pro Ala Leu Lys Lys
500 505 510

Ala Ala Ser Trp Leu Glu His Leu Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Lys Phe Ile Ser Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Gln Glu Thr Pro Ile Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Gln Ser Thr Met Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Gly His Ile Tyr Pro Leu
595 600 605

Leu Ala Leu Ala His Tyr Val Lys Lys Tyr Arg Lys
610 615 620


<210> 54
<211> 619
<212> PRT
<213> Bacillus mycoides

<400> 54
Met Leu Leu Tyr Glu Lys Val Arg Gln Glu Val Glu Arg Lys Val Thr
1 5 10 15

Ala Leu Arg Thr Thr Gln Tyr Gln Asp Gly Ala Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ser Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Arg Leu
35 40 45

Leu Gly Gln Asn Gly Glu Met Glu Pro Phe Val Thr Arg Val Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Ser Val
65 70 75 80

Gly Asn Leu Ser Thr Thr Ile Asn Ala Tyr Val Ala Leu Leu Ala Ser
85 90 95

Gly Arg Tyr Thr Lys Glu Asp Ile Asn Met Lys Arg Ala Glu Ala Phe
100 105 110

Ile Arg Arg Gln Gly Gly Ile Thr Lys Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Leu His Gly Gly Tyr Glu Tyr Pro Ser Leu Phe His Phe
130 135 140

Pro Thr Pro Met Leu Phe Leu Pro Glu Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Ile Cys
165 170 175

Met Asn Lys Arg Phe Thr Val Ser Lys Thr Ile Phe Pro Asn Leu Asp
180 185 190

Tyr Ile Ser Gly Gly Ser Lys Lys Gln Trp Phe Arg Glu Glu Arg Ser
195 200 205

Pro Leu Phe Gln Thr Leu Leu Gly Asp Val Lys Lys Phe Leu Ser Tyr
210 215 220

Pro Leu Ser Leu Gln His Lys Gly Tyr Lys Glu Ala Glu Arg Phe Met
225 230 235 240

Ile Glu Arg Ile Glu Thr Asn Gly Thr Leu Tyr Ser Tyr Ala Ser Ala
245 250 255

Thr Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Ile Gln
260 265 270

Ser Pro Leu Ile Ser Asn Ala Val Leu Gly Leu Lys Ser Tyr Ile Trp
275 280 285

Asn Met Asn Lys Gly Thr His Leu Gln Asn Ser Pro Ser Thr Val Trp
290 295 300

Asp Thr Ala Leu Leu Ser Tyr Ser Leu Gln Glu Ala Gly Val Pro Asn
305 310 315 320

Asp Asn Gln Met Ile Gln Lys Ala Thr Asp Tyr Leu Leu Gln Lys Gln
325 330 335

His Lys Glu Lys Lys Asp Trp Ser Val His Ala Pro Ser Leu Asp Ala
340 345 350

Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp
355 360 365

Asp Thr Thr Ala Ala Leu Arg Ala Ile Ala Arg Ser Arg Glu Gly Asn
370 375 380

Gln Arg Ile Glu Glu Asp Trp Arg Lys Gly Ile Glu Trp Val Lys Gly
385 390 395 400

Leu Gln Asn Ile Asp Gly Gly Trp Ala Ala Phe Glu Arg Gly Val Thr
405 410 415

Ser His Phe Leu Thr His Leu Pro Leu Asp Asn Ala Gly Asp Met Thr
420 425 430

Thr Asp Pro Ser Thr Ser Asp Ile Thr Gly Arg Val Leu Glu Phe Phe
435 440 445

Gly Thr Tyr Ala Pro His Gln Leu Lys Asp Asp Gln Lys Asp Arg Ala
450 455 460

Ile Lys Trp Leu Met Gln Ala Gln Glu Lys Asn Gly Ser Trp Tyr Gly
465 470 475 480

Lys Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr Gly
485 490 495

Leu Arg Ala Val Gly Val Pro Ser Asn His Thr Ala Leu Gln Lys Ala
500 505 510

Ala Thr Trp Leu Glu Arg Ile Gln His Asn Asp Gly Gly Trp Gly Glu
515 520 525

Ser Cys Arg Ser Ser Ile Glu Lys His Phe Ile Ser Leu Pro Phe Ser
530 535 540

Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Thr Phe Tyr
545 550 555 560

Asp Thr Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ala
565 570 575

His Leu Asn Gln Asn Gln Asp Tyr Pro Thr Gly Ile Gly Leu Pro Asp
580 585 590

Gly Phe Tyr Ile Arg Tyr His Ser Tyr His His Ile Phe Pro Ile Leu
595 600 605

Thr Phe Ala His Tyr Ile Lys Lys Tyr Met Lys
610 615


<210> 55
<211> 619
<212> PRT
<213> Bacillus pseudomycoides

<400> 55
Met Leu Leu Tyr Glu Lys Val Arg Gln Glu Val Glu Arg Lys Val Thr
1 5 10 15

Ala Leu Arg Thr Met Gln Tyr Gln Asp Gly Ala Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ser Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Arg Leu
35 40 45

Leu Gly Gln Asn Gly Glu Met Glu Pro Phe Val Thr Arg Val Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Ser Val
65 70 75 80

Gly Asn Leu Ser Thr Thr Ile Asn Ala Tyr Val Ala Leu Leu Ala Ser
85 90 95

Gly Arg Tyr Thr Lys Glu Asp Ile Asn Met Lys Arg Ala Glu Ala Phe
100 105 110

Ile Arg Arg Gln Gly Gly Ile Thr Lys Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Leu His Gly Gly Tyr Glu Tyr Pro Ser Leu Phe His Phe
130 135 140

Pro Thr Pro Met Leu Phe Leu Pro Glu Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Ile Cys
165 170 175

Met Asn Lys Arg Phe Thr Val Ser Lys Thr Ile Leu Pro Asn Leu Asp
180 185 190

Tyr Ile Ser Gly Gly Ser Lys Lys Gln Trp Phe Arg Glu Glu Arg Ser
195 200 205

Ser Leu Phe Gln Arg Leu Leu Gly Asp Val Lys Lys Phe Leu Ser Tyr
210 215 220

Pro Leu Ser Leu Gln His Lys Gly Tyr Lys Glu Ala Glu Arg Phe Met
225 230 235 240

Ile Glu Arg Ile Glu Thr Asn Gly Thr Leu Tyr Ser Tyr Ala Ser Ala
245 250 255

Thr Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Ile Gln
260 265 270

Ser Pro Leu Ile Ser Asn Ala Val Leu Gly Leu Lys Ser Tyr Ile Trp
275 280 285

Asn Met Asn Lys Gly Thr His Leu Gln Asn Ser Pro Ser Thr Val Trp
290 295 300

Asp Thr Ala Leu Leu Ser Tyr Ser Leu Gln Glu Ala Gly Val Pro Asn
305 310 315 320

Asp Asn Gln Met Ile Gln Lys Ala Thr Asp Tyr Leu Leu Gln Lys Gln
325 330 335

His Lys Glu Lys Lys Asp Trp Ser Val His Ala Pro Ser Leu Asp Ala
340 345 350

Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp
355 360 365

Asp Thr Thr Ala Ala Leu Arg Ala Ile Ala Arg Ser Arg Glu Gly Asn
370 375 380

Gln Arg Ile Glu Glu Ala Trp Arg Lys Gly Ile Glu Trp Val Lys Gly
385 390 395 400

Leu Gln Asn Ile Asp Gly Gly Trp Ala Ala Phe Glu Arg Gly Val Thr
405 410 415

Ser His Phe Leu Thr His Leu Pro Leu Asp Asn Ala Gly Asp Met Thr
420 425 430

Thr Asp Pro Ser Thr Ser Asp Ile Thr Gly Arg Val Leu Glu Phe Phe
435 440 445

Gly Thr Tyr Ala Pro His Gln Leu Lys Asp Asp Gln Lys Asp Arg Ala
450 455 460

Ile Lys Trp Leu Met Gln Ala Gln Glu Lys Asn Gly Ser Trp Tyr Gly
465 470 475 480

Lys Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr Gly
485 490 495

Leu Arg Ala Val Gly Val Pro Ser Asn His Thr Ala Leu Gln Lys Ala
500 505 510

Ala Thr Trp Leu Glu Arg Ile Gln His Asn Asp Gly Gly Trp Gly Glu
515 520 525

Ser Cys Arg Ser Ser Ile Glu Lys His Phe Ile Ser Leu Pro Phe Ser
530 535 540

Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Thr Phe Tyr
545 550 555 560

Asp Thr Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ala
565 570 575

His Leu Asn Gln Asn Gln Asp Tyr Pro Thr Gly Ile Gly Leu Pro Asp
580 585 590

Gly Phe Tyr Ile Arg Tyr His Ser Tyr His His Ile Phe Pro Ile Leu
595 600 605

Thr Phe Ala His Tyr Ile Lys Lys Tyr Met Lys
610 615


<210> 56
<211> 624
<212> PRT
<213> Bacillus pumilus

<400> 56
Met Gln Asp Phe Lys Thr Lys Val Asn Val Tyr Met Asp Glu Leu His
1 5 10 15

Met Gln Met Gln His Arg Gln Arg Glu Asp Gly Ala Phe Val Phe Cys
20 25 30

Phe Glu Gly Ser Met Met Thr Asn Ala Phe Leu Ile Met Leu Leu Lys
35 40 45

Ala Val Gly Asp Thr Asp Gln Ala Leu Val His Gln Leu Ala Glu Ala
50 55 60

Ile Arg Glu Lys Gln Asn Glu Asp Gly Ser Phe Ser Leu Tyr His Asp
65 70 75 80

Gln Ala Gly His Val Thr Ala Thr Val Gln Gly Tyr Cys Gly Met Leu
85 90 95

Val Ser Gly Arg Tyr Gln Gln Asp Glu Pro His Met Glu Lys Ala Ala
100 105 110

Arg Tyr Ile Arg Ser Lys Gly Gly Leu Lys Asp Val His Phe Met Thr
115 120 125

Lys Trp Met Leu Ala Val Asn Gly Met His Pro Trp Pro Tyr Phe Tyr
130 135 140

Ala Pro Leu Ser Phe Leu Leu Ile Pro Thr Tyr Phe Pro Leu His Phe
145 150 155 160

Tyr His Leu Ser Ala Tyr Ala Arg Ile His Phe Val Pro Met Met Ile
165 170 175

Ala Leu Asn Lys Arg Tyr Thr Ser His Glu Gln Phe Pro Ser Leu Ser
180 185 190

His Leu Asp Ala Asn Met Ser Lys Asn Pro Phe Asp Trp Phe Met Ala
195 200 205

Arg Glu Glu Arg Ser Thr His His Phe Leu Ala Tyr Met Arg Ser Tyr
210 215 220

Thr Ala Leu Asp Ser Arg Phe Asp Phe Phe Gly Tyr Glu Ala Ala Lys
225 230 235 240

Arg Tyr Met Phe Asp Arg Leu Glu Lys Asp Gly Thr Leu Tyr Ser Tyr
245 250 255

Leu Ser Ala Ser Ile Phe Met Val Tyr Ala Leu Met Ser Leu Gly Tyr
260 265 270

Ser Pro Gly His His Leu Ile Leu Lys Ala Val Lys Gly Met Lys Gln
275 280 285

Leu Val Thr Asp Cys Gly Gly Lys Lys Tyr Ala Glu Asn Ser Thr Ser
290 295 300

Thr Val Trp Asp Thr Ala Leu Val Ser Tyr Ala Ser Gln Arg Ala Gly
305 310 315 320

Arg Thr Gln Asp Asp Pro Val Ile Lys Lys Ser Phe Thr Tyr Leu Leu
325 330 335

Asn Arg Gln Gln Met Lys Lys Ala Asp Trp Ala Ile His Asn Arg His
340 345 350

Ala Ala Pro Gly Gly Phe Gly Phe Ser Asp Leu Asn Thr Asn Asn Pro
355 360 365

Asp Cys Asp Asp Thr Gln Ile Val Leu Lys Ala Ile Pro Gln Thr Tyr
370 375 380

Ala Pro Val Gln Trp Lys Arg Gly Phe Asp Trp Leu Leu Ser Met Gln
385 390 395 400

Asn Arg Asp Gly Gly Phe Ser Ala Phe Glu Lys Asn Gln Asp His Phe
405 410 415

Leu Leu Arg His Leu Pro Leu Glu Ser Ala Glu Asp Ala Ala Ile Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu His Leu Ile Ala Ser
435 440 445

Glu Glu Asn Asp Lys Ser Pro Leu Met Gln Arg Gln Lys Asp His Cys
450 455 460

Val Lys Trp Leu Leu Asp His Gln Glu Lys Asp Gly Ser Trp Tyr Gly
465 470 475 480

Arg Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr Gly
485 490 495

Leu Lys Ala Ser Gly Ile Pro Ser Ser His Pro Ala Val Gln Lys Ala
500 505 510

Cys Arg Phe Leu Lys Thr Ile Gln Leu Glu Asp Gly Ser Phe Gly Glu
515 520 525

Ser Cys Lys Ser Ser Glu Val Lys Arg Tyr Val Pro Leu Pro Phe Gly
530 535 540

Thr Val Val Gln Thr Ala Trp Ala Ala Glu Ala Leu Leu Gln Tyr Val
545 550 555 560

Gln Pro Asp Asp Lys Ser Ile Leu Lys Ala Ile Ser Phe Leu Ile Gln
565 570 575

His Gln His Ser Ser Lys Ala Leu His Tyr Pro Val Gly Ile Gly Leu
580 585 590

Pro Lys Gln Phe Tyr Ile Thr Tyr His Ser Tyr Pro Phe Val Phe Pro
595 600 605

Met Met Ala Cys Ser Thr Phe Leu Glu Glu Met Arg Arg Lys Asn Glu
610 615 620




<210> 57
<211> 624
<212> PRT
<213> Bacillus pumilus

<400> 57
Met Gln Asp Phe Lys Thr Lys Val Asn Glu Tyr Ile Asp Glu Leu His
1 5 10 15

Met Gln Leu Gln Arg Arg Gln Arg Glu Asp Gly Ala Phe Val Phe Cys
20 25 30

Phe Glu Gly Pro Met Met Thr Asn Ala Phe Leu Ile Met Leu Leu Lys
35 40 45

Ala Val Gly Asp Ser Asp Gln Ala Leu Val His Gln Leu Ala Glu Ala
50 55 60

Ile Arg Glu Lys Gln Asn Glu Asp Gly Ser Phe Ser Leu Tyr His Asp
65 70 75 80

Gln Ala Gly His Val Thr Ala Thr Val Gln Gly Tyr Cys Gly Met Leu
85 90 95

Val Ser Gly Arg Tyr Gln Gln Asp Glu Pro His Met Glu Lys Ala Ala
100 105 110

His Phe Ile Arg Ser Asn Gly Gly Leu Lys Asp Val His Phe Met Thr
115 120 125

Lys Trp Met Leu Ala Val Asn Gly Met His Pro Trp Pro Tyr Phe Tyr
130 135 140

Ala Pro Leu Ser Phe Leu Leu Ile Pro Thr Tyr Phe Pro Leu His Phe
145 150 155 160

Tyr His Leu Ser Ala Tyr Ala Arg Ile His Phe Val Pro Met Met Ile
165 170 175

Ala Leu Asn Lys Arg Tyr Thr Ser His Glu Gln Phe Pro Ser Leu Ala
180 185 190

His Leu Asp Ala Asn Met Ser Lys Asn Pro Phe Asp Trp Phe Met Ala
195 200 205

Arg Glu Glu Arg Ser Thr His His Phe Leu Ala Tyr Met Arg Ser Tyr
210 215 220

Thr Ala Leu Asp Ser Arg Leu Asp Phe Phe Gly Tyr Glu Ala Ala Lys
225 230 235 240

Arg Tyr Met Phe Asp Arg Leu Glu Lys Asp Gly Thr Leu Tyr Ser Tyr
245 250 255

Leu Ser Ala Ser Ile Phe Met Val Tyr Ala Leu Met Ser Leu Gly Tyr
260 265 270

Ser Pro Gly His His Leu Ile Leu Lys Ala Val Lys Gly Met Lys Gln
275 280 285

Leu Val Thr Asp Cys Gly Gly Arg Lys Tyr Ala Glu Asn Ser Thr Ser
290 295 300

Asn Val Trp Asp Thr Ala Leu Val Ser Tyr Ala Ser Gln Gln Ala Gly
305 310 315 320

Arg Thr Gln Asp Asp Pro Val Ile Lys Lys Ser Phe Thr Tyr Leu Leu
325 330 335

Asn Arg Gln Gln Met Lys Lys Ala Asp Trp Ala Ile His Asn Arg His
340 345 350

Ala Ala Pro Gly Gly Phe Gly Phe Ser Asp Leu Asn Thr Asn Asn Pro
355 360 365

Asp Cys Asp Asp Thr Gln Ile Val Leu Lys Ala Val Pro Gln Thr Tyr
370 375 380

Ala Pro Val Gln Trp Lys Arg Gly Phe Asp Trp Leu Leu Ser Met Gln
385 390 395 400

Asn Gln Asp Gly Gly Phe Ser Ala Phe Glu Lys Asn Gln Asn His Phe
405 410 415

Leu Leu Arg His Leu Pro Leu Glu Ser Ala Glu Asp Ala Ala Ile Asp
420 425 430

Pro Ser Thr Pro Asp Ile Ala Gly Arg Val Leu His Leu Ile Ala Leu
435 440 445

Glu Glu Asn Ser Met Ser Pro Leu Met Gln Arg Gln Lys Asp His Cys
450 455 460

Val Lys Trp Leu Leu Asp His Gln Glu Lys Asn Gly Ser Trp Phe Gly
465 470 475 480

Arg Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr Gly
485 490 495

Leu Lys Thr Ala Gly Ile Ser Ser Ser His Ser Ala Val Gln Lys Ala
500 505 510

Cys Arg Phe Leu Lys Thr Ile Gln Leu Glu Asp Gly Ser Phe Gly Glu
515 520 525

Ser Cys Lys Ser Ala Glu Val Lys Arg Tyr Val Pro Leu Pro Phe Gly
530 535 540

Thr Val Val Gln Thr Ala Trp Ala Ala Glu Ala Leu Leu Gln Tyr Val
545 550 555 560

Gln Pro Asp Asp Lys Val Ile Leu Lys Ala Ile Ser Phe Leu Ile Gln
565 570 575

His Gln His Ser Ser Glu Ala Leu His Tyr Pro Val Gly Ile Gly Leu
580 585 590

Pro Lys Gln Phe Tyr Ile Thr Tyr His Ser Tyr Pro Phe Val Phe Pro
595 600 605

Met Met Ala Cys Ser Thr Phe Leu Glu Glu Met Arg Arg Lys Asn Glu
610 615 620




<210> 58
<211> 638
<212> PRT
<213> Bacillus sp.

<400> 58
Met Lys Asn Arg Asn Lys Gly Ala Gly Cys Met Gln Leu Val Lys Ser
1 5 10 15

Glu Ile Glu Arg Leu Lys Gln Gln Leu Leu Ser Glu Gln Thr Pro Asp
20 25 30

Gly Ser Trp Asn His Pro Phe Asp Thr Gly Cys Met Thr Asp Ile Tyr
35 40 45

Met Ile Val Leu Leu Arg Thr Leu Glu Glu Glu Asp Glu Glu Glu Leu
50 55 60

Ile Lys Glu Leu Ala Lys Gly Ile Leu Ser Arg Gln Gly Lys Asp Gly
65 70 75 80

Ala Trp Arg Leu Phe His Asp His His Glu Gly Ser Leu Ser Leu Thr
85 90 95

Ile Glu Ala Tyr Tyr Ala Leu Leu Tyr Ser Gly Tyr Tyr Glu Lys Asn
100 105 110

His Pro Ala Leu Val Lys Ala Arg Arg Val Ile Thr Lys Gly Gly Gly
115 120 125

Leu Lys Lys Ala Gly Met Tyr Thr Lys Ile Met Leu Ala Leu Thr Gly
130 135 140

Gln Tyr Pro Trp Pro Leu Leu Phe Pro Val Pro Met Glu Val Ile Leu
145 150 155 160

Leu Pro Arg Ser Phe Pro Leu Asn Met Tyr Asp Ile Ser Val Phe Gly
165 170 175

Arg Ser Asn Leu Ile Pro Val Ile Leu Leu Gly Asn Lys Lys Phe Ser
180 185 190

Arg Lys Thr Ala Leu Ser Pro Asp Leu Gly Asp Leu Ser Val Arg Asp
195 200 205

Asp Asp Asp Pro Trp Pro Glu Leu Arg Ser Ala Glu Trp Arg Ser Leu
210 215 220

Thr Ser Phe Leu Ala Ala Gly Val Lys Ala Leu Val Gly Ile Pro Arg
225 230 235 240

Gln Ile Arg Ala Trp Ser Ile Glu Lys Ala Arg Glu Tyr Met Gln Ser
245 250 255

His Thr Glu Pro Asp Gly Thr Leu Tyr Asn Tyr Phe Ser Ser Thr Phe
260 265 270

Tyr Met Ile Phe Ala Leu Leu Ala Leu Gly Gly Gly Pro Glu Glu Pro
275 280 285

Ala Ile Arg Asn Ala Val Ala Gly Leu Lys Arg Met Thr Val Lys Ala
290 295 300

Asp Gly Arg Thr His Ile Gln Tyr Thr Thr Ala Ala Val Trp Asn Thr
305 310 315 320

Ala Leu Ile Ser His Ala Leu Gln Glu Ala Gly Val Pro Pro Lys Glu
325 330 335

Asn Ala Ile Gln Lys Ala Asn Gln Tyr Leu Ala Gly Gln Gln His Arg
340 345 350

Arg Phe Gly Asp Trp Ile Val His Asn Thr Lys Ala Glu Pro Gly Gly
355 360 365

Trp Gly Phe Ser Arg Phe Asn Thr Ile Asn Pro Asp Val Asp Asp Thr
370 375 380

Thr Ala Ala Leu Arg Ser Leu Tyr Gln Pro Ala Arg Glu Lys Pro His
385 390 395 400

Tyr Asp Asp Ile Trp Lys Lys Gly Leu Leu Trp Thr Leu Ser Met Gln
405 410 415

Asn Arg Asp Gly Gly Trp Pro Ala Phe Glu Arg Asn Val Asp Lys Lys
420 425 430

Leu Leu His Leu Leu Pro Ile Gln Gly Ala Glu Phe Ile Leu Thr Asp
435 440 445

Pro Ser Thr Ala Asp Leu Thr Gly Arg Thr Leu Glu Phe Leu Gly Lys
450 455 460

Ala Gly Tyr Ala Asp Ala Ser Leu Pro Pro Ile Lys Lys Ala Val Lys
465 470 475 480

Trp Leu Lys Lys His Gln Glu Pro Asn Gly Ser Trp Tyr Gly Arg Trp
485 490 495

Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Val Thr Gly Met Ala
500 505 510

Ala Val Gly Val Thr Leu Glu Asp Lys Ser Met Lys Lys Gly Ile Asp
515 520 525

Trp Leu Leu Ser Ile Gln Asn Glu Asp Gly Gly Trp Gly Glu Ser Cys
530 535 540

Arg Ser Asp Met Glu Lys Lys Tyr Ile Pro Leu Lys Glu Ser Thr Leu
545 550 555 560

Thr Gln Thr Ala Trp Ala Val Asp Ala Leu Ala Ala Ala Gly Met Ala
565 570 575

Asp Ser Thr Pro Ser Arg Lys Gly Ala Ala Phe Leu Val Arg Glu Gly
580 585 590

Lys Arg Lys Asp Trp Thr Ala Asp Tyr Pro Met Gly Gln Gly Met Ala
595 600 605

Asn Phe Phe Tyr Ile His Tyr His Ser Tyr Arg Cys Ile Trp Pro Leu
610 615 620

Leu Ala Leu Ser His Tyr Ile Glu Lys Ser Glu Ala Pro Asp
625 630 635


<210> 59
<211> 625
<212> PRT
<213> Bacillus sp.

<400> 59
Met Glu Thr Leu Ile Asp Pro Glu Ile Ser Arg Leu Thr Gln Arg Leu
1 5 10 15

Leu Glu Asp Gln Glu Glu Asp Gly Ala Trp Arg Tyr Cys Phe Glu Asn
20 25 30

Ser Leu Met Thr Asp Ala Tyr Met Ile Val Leu Ile Arg Ser Leu Gly
35 40 45

Ile Lys Lys Glu Arg Leu Val Gln Glu Leu Ala Asp Arg Leu Leu Ser
50 55 60

Gln Gln Glu Glu Lys Gly Phe Trp Lys Ile Tyr Arg Asp Glu Val Glu
65 70 75 80

Gly Asn Leu Ser Ala Thr Val Glu Ala Tyr Phe Ala Leu Leu Trp Ser
85 90 95

Gly Ala Val Lys Glu Lys Asp Glu Asn Met Val Lys Ala Arg Asp Cys
100 105 110

Ile Leu Ser Gly Gly Gly Leu Asp Lys Val His Ser Met Thr Lys Phe
115 120 125

Met Leu Ala Ala His Gly Gln Tyr Pro Trp Asp Arg Phe Phe Pro Val
130 135 140

Pro Val Glu Val Ile Leu Leu Pro Thr Tyr Phe Pro Val Ser Phe Thr
145 150 155 160

Asp Phe Ser Ala Tyr Ala Arg Val His Leu Ala Pro Leu Leu Leu Leu
165 170 175

Lys Ser Glu Arg Tyr Ile Arg Lys Thr Ser Thr Thr Pro Asp Leu Ser
180 185 190

Tyr Leu Leu Lys Asp Gln Glu Asp Phe Ser Phe Phe Arg Glu Glu Glu
195 200 205

Arg Ser Phe Ile Glu Tyr Val Thr Ser Gly Val Glu Ala Ile Ala Ala
210 215 220

Phe Pro Ala Asn Leu Asn Asp Leu Ala Lys Lys Thr Ala Leu Asn Tyr
225 230 235 240

Met Leu Ala Arg Leu Glu Pro Asp Gly Ser Leu Tyr Ser Tyr Phe Ser
245 250 255

Ser Ser Phe Tyr Met Ile Ile Ala Leu Leu Ser Gln Gly Tyr Ser Arg
260 265 270

Lys Asp Pro Leu Val Val Asn Ala Ile Lys Ala Leu Ile Ser Tyr Gln
275 280 285

Cys Lys Gly Asp Gly Tyr Pro His Ile Gln Asn Ser Pro Ser Thr Ile
290 295 300

Trp Asp Thr Ala Leu Ile Ser His Ala Leu Gln Ser Ser Gly Val Asp
305 310 315 320

Ser Arg Asn Ala Gln Ile Leu Lys Ala Ser His Tyr Leu Tyr Arg His
325 330 335

Gln His Thr Gln Lys Gly Asp Trp Ala Ser Glu Ala Pro Gln Thr Ala
340 345 350

Pro Gly Gly Trp Gly Phe Ser Glu Ser Asn Thr Ile Asn Pro Asp Val
355 360 365

Asp Asp Thr Thr Ala Ala Leu Arg Ala Leu Lys Leu Asp Ala Tyr Thr
370 375 380

Asp Pro Val Lys Arg Met Ala Trp Asn Arg Gly Val Lys Trp Ala Leu
385 390 395 400

Ser Met Gln Asn Lys Asp Gly Gly Trp Pro Ala Phe Glu Lys Asn Lys
405 410 415

Asn Lys Asp Ile Leu Ser Trp Val Pro Met Asp Gly Ala Glu Asp Ala
420 425 430

Ala Leu Asp Arg Ser Cys Ala Asp Leu Thr Gly Arg Thr Leu Glu Phe
435 440 445

Leu Gly Asn Asp Ala Gly Met Gly Arg Glu Asn Ser Gln Val Leu Lys
450 455 460

Gly Ile Glu Trp Leu Met Asn Asn Gln Glu Asn Asp Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr
485 490 495

Gly Met Met Ala Ala Gly Met Ser Ala Asp His Gln Ser Ile Ile Lys
500 505 510

Ala Ile Lys Trp Leu Tyr Gln Ile Gln Asn Ser Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Arg Ser Asp Lys Glu Arg Lys Tyr Ile Ser Leu Gly Ala
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Ile
545 550 555 560

Asn Asp His Pro Thr Lys Glu Ile Asp Arg Gly Ile Glu Ser Leu Val
565 570 575

Arg Leu Leu Asn Thr Asp Asp Trp Arg Lys Glu Tyr Pro Thr Gly Ala
580 585 590

Gly Leu Pro Gly Arg Phe Tyr Ile His Tyr His Ser Tyr Pro Tyr Ile
595 600 605

Trp Pro Leu Leu Ala Leu Ser Asn Tyr Lys Thr Lys Phe Leu Glu Val
610 615 620

Arg
625


<210> 60
<211> 632
<212> PRT
<213> Bacillus subtilis

<400> 60
Met Gly Thr Leu Gln Glu Lys Val Arg Arg Phe Gln Lys Lys Thr Ile
1 5 10 15

Thr Glu Leu Arg Asp Arg Gln Asn Ala Asp Gly Ser Trp Thr Phe Cys
20 25 30

Phe Glu Gly Pro Ile Met Thr Asn Ser Phe Phe Ile Leu Leu Leu Thr
35 40 45

Ser Leu Asp Glu Gly Glu Asn Glu Lys Glu Leu Ile Ser Ser Leu Ala
50 55 60

Ala Gly Ile His Ala Lys Gln Gln Pro Asp Gly Thr Phe Ile Asn Tyr
65 70 75 80

Pro Asp Glu Thr Arg Gly Asn Leu Thr Ala Thr Val Gln Gly Tyr Val
85 90 95

Gly Met Leu Ala Ser Gly Cys Phe His Arg Thr Glu Pro His Met Lys
100 105 110

Lys Ala Glu Gln Phe Ile Ile Ser His Gly Gly Leu Arg His Val His
115 120 125

Phe Met Thr Lys Trp Met Leu Ala Ala Asn Gly Leu Tyr Pro Trp Pro
130 135 140

Ala Leu Tyr Leu Pro Leu Ser Leu Met Ala Leu Pro Pro Thr Leu Pro
145 150 155 160

Ile His Phe Tyr Gln Phe Ser Ser Tyr Ala Arg Ile His Phe Ala Pro
165 170 175

Met Ala Val Thr Leu Asn Gln Arg Phe Val Leu Ile Asn Arg Asn Ile
180 185 190

Ser Ser Leu His His Leu Asp Pro His Met Thr Lys Asn Pro Phe Thr
195 200 205

Trp Leu Arg Ser Asp Ala Phe Glu Glu Arg Asp Leu Thr Ser Ile Leu
210 215 220

Leu His Trp Lys Arg Val Phe His Ala Pro Phe Ala Phe Gln Gln Leu
225 230 235 240

Gly Leu Gln Thr Ala Lys Thr Tyr Met Leu Asp Arg Ile Glu Lys Asp
245 250 255

Gly Thr Leu Tyr Ser Tyr Ala Ser Ala Thr Ile Tyr Met Val Tyr Ser
260 265 270

Leu Leu Ser Leu Gly Val Ser Arg Tyr Ser Pro Ile Ile Arg Arg Ala
275 280 285

Ile Thr Gly Ile Lys Ser Leu Val Thr Lys Cys Asn Gly Ile Pro Tyr
290 295 300

Leu Glu Asn Ser Thr Ser Thr Val Trp Asp Thr Ala Leu Ile Ser Tyr
305 310 315 320

Ala Leu Gln Lys Asn Gly Val Thr Glu Thr Asp Gly Ser Val Thr Lys
325 330 335

Ala Ala Asp Phe Leu Leu Glu Arg Gln His Thr Lys Ile Ala Asp Trp
340 345 350

Ser Val Lys Asn Pro Asn Ser Val Pro Gly Gly Trp Gly Phe Ser Asn
355 360 365

Ile Asn Thr Asn Asn Pro Asp Cys Asp Asp Thr Thr Ala Val Leu Lys
370 375 380

Ala Ile Pro Arg Asn His Ser Pro Ala Ala Trp Glu Arg Gly Val Ser
385 390 395 400

Trp Leu Leu Ser Met Gln Asn Asn Asp Gly Gly Phe Ser Ala Phe Glu
405 410 415

Lys Asn Val Asn His Pro Leu Ile Arg Leu Leu Pro Leu Glu Ser Ala
420 425 430

Glu Asp Ala Ala Val Asp Pro Ser Thr Ala Asp Leu Thr Gly Arg Val
435 440 445

Leu His Phe Leu Gly Glu Lys Val Gly Phe Thr Glu Lys His Gln His
450 455 460

Ile Gln Arg Ala Val Lys Trp Leu Phe Glu His Gln Glu Gln Asn Gly
465 470 475 480

Ser Trp Tyr Gly Arg Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala
485 490 495

Ala Leu Thr Gly Met His Ala Cys Gly Val Asp Arg Lys His Pro Gly
500 505 510

Ile Gln Lys Ala Leu Arg Trp Leu Lys Ser Ile Gln Asn Asp Asp Gly
515 520 525

Ser Trp Gly Glu Ser Cys Lys Ser Ala Glu Ile Lys Thr Tyr Val Pro
530 535 540

Leu His Arg Gly Thr Ile Val Gln Thr Ala Trp Ala Leu Asp Ala Leu
545 550 555 560

Leu Thr Tyr Glu Asn Ser Glu His Pro Ser Val Val Lys Gly Met Gln
565 570 575

Tyr Leu Thr Asp Ser Ser Ser His Ser Ala Asp Ser Leu Ala Tyr Pro
580 585 590

Ala Gly Ile Gly Leu Pro Lys Gln Phe Tyr Ile Arg Tyr His Ser Tyr
595 600 605

Pro Tyr Val Phe Ser Leu Leu Ala Val Gly Lys Tyr Leu Asp Ser Ile
610 615 620

Glu Lys Glu Thr Ala Asn Glu Thr
625 630


<210> 61
<211> 556
<212> PRT
<213> Bacillus subtilis

<400> 61
Met Gly Thr Leu Gln Glu Lys Val Arg Arg Phe Gln Lys Lys Thr Ile
1 5 10 15

Thr Glu Leu Arg Asp Arg Gln Asn Ala Asp Gly Ser Trp Thr Phe Cys
20 25 30

Phe Glu Gly Pro Ile Met Thr Asn Ser Phe Phe Ile Leu Leu Leu Thr
35 40 45

Ser Leu Asp Glu Gly Glu Asn Glu Lys Glu Leu Ile Ser Ser Leu Ala
50 55 60

Ala Gly Ile His Ala Lys Gln Gln Pro Asp Gly Thr Phe Ile Asn Tyr
65 70 75 80

Pro Asp Glu Thr Arg Gly Asn Leu Thr Ala Thr Val Gln Gly Tyr Val
85 90 95

Gly Met Leu Ala Ser Gly Cys Phe His Arg Thr Glu Pro His Met Lys
100 105 110

Lys Ala Glu Gln Phe Ile Ile Ser His Gly Gly Leu Arg His Val His
115 120 125

Phe Met Thr Lys Trp Met Leu Ala Ala Asn Gly Leu Tyr Pro Trp Pro
130 135 140

Ala Leu Tyr Leu Pro Leu Ser Leu Met Ala Leu Pro Pro Thr Leu Pro
145 150 155 160

Ile His Phe Tyr Gln Phe Ser Ser Tyr Ala Arg Ile His Phe Ala Pro
165 170 175

Met Ala Val Thr Leu Asn Gln Arg Phe Val Leu Ile Asn Arg Asn Ile
180 185 190

Ser Ser Leu His His Leu Asp Pro His Met Thr Lys Asn Pro Phe Thr
195 200 205

Trp Leu Arg Ser Asp Ala Phe Glu Glu Arg Asp Leu Thr Ser Ile Leu
210 215 220

Leu His Trp Lys Arg Val Phe His Ala Pro Phe Ala Phe Gln Gln Leu
225 230 235 240

Gly Leu Gln Thr Ala Lys Thr Tyr Met Leu Asp Arg Ile Glu Lys Asp
245 250 255

Gly Thr Leu Tyr Ser Tyr Ala Ser Ala Thr Ile Tyr Met Val Tyr Ser
260 265 270

Leu Leu Ser Leu Gly Val Ser Arg Tyr Ser Pro Ile Ile Arg Arg Ala
275 280 285

Ile Thr Gly Ile Lys Ser Leu Val Thr Lys Cys Asn Gly Ile Pro Tyr
290 295 300

Leu Glu Asn Ser Thr Ser Thr Val Trp Asp Thr Ala Leu Ile Ser Tyr
305 310 315 320

Ala Leu Gln Lys Asn Gly Val Thr Glu Thr Asp Gly Ser Val Thr Lys
325 330 335

Ala Ala Asp Phe Leu Leu Glu Arg Gln His Thr Lys Ile Ala Asp Trp
340 345 350

Ser Val Lys Asn Pro Asn Ser Val Pro Gly Gly Trp Gly Phe Ser Asn
355 360 365

Ile Asn Thr Asn Asn Pro Asp Cys Asp Asp Thr Thr Ala Val Leu Lys
370 375 380

Ala Ile Pro Arg Asn His Ser Pro Ala Ala Trp Glu Arg Gly Val Ser
385 390 395 400

Trp Leu Leu Ser Met Gln Asn Asn Asp Gly Gly Phe Ser Ala Phe Glu
405 410 415

Lys Asn Val Asn His Pro Leu Ile Arg Leu Leu Pro Leu Glu Ser Ala
420 425 430

Glu Asp Ala Ala Val Asp Pro Ser Thr Ala Asp Leu Thr Gly Arg Val
435 440 445

Leu His Phe Leu Gly Glu Lys Val Gly Phe Thr Glu Lys His Gln His
450 455 460

Ile Gln Arg Ala Val Lys Trp Leu Phe Glu His Gln Glu Gln Asn Gly
465 470 475 480

Ser Trp Tyr Gly Arg Trp Gly Val Cys Tyr Ile Tyr Gly Thr Trp Ala
485 490 495

Ala Leu Thr Gly Met His Ala Cys Gly Leu Thr Glu Ser Ile Pro Val
500 505 510

Tyr Lys Arg Leu Cys Val Gly Ser Asn Pro Tyr Lys Met Met Thr Glu
515 520 525

Ala Gly Glu Asn Pro Ala Lys Ala Pro Lys Ser Lys His Met Tyr Arg
530 535 540

Phe Ile Glu Glu Pro Leu Tyr Lys Arg Pro Gly Leu
545 550 555


<210> 62
<211> 631
<212> PRT
<213> Bacillus thuringiensis

<400> 62
Met Asn Ile Val Ile Arg Ile Ser Lys Gly Trp Val Ser Asn Leu Leu
1 5 10 15

Leu Asp Glu Lys Ala His Glu Glu Ile Val Arg Arg Ala Thr Ala Leu
20 25 30

Gln Thr Met Gln Trp Gln Asp Gly Thr Trp Arg Phe Cys Phe Glu Gly
35 40 45

Ala Pro Leu Thr Asp Cys His Thr Ile Phe Leu Leu Lys Leu Leu Gly
50 55 60

Arg Asp Lys Glu Ile Glu Pro Phe Val Glu Arg Val Ala Ser Leu Gln
65 70 75 80

Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly Gly Asn
85 90 95

Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser Lys Lys
100 105 110

Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Asn Phe Ile Gln
115 120 125

Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe Leu Leu
130 135 140

Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Val Pro Thr
145 150 155 160

Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Phe Ser Ile Phe Glu Leu
165 170 175

Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys Leu Asn
180 185 190

Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn His Ile
195 200 205

Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro Val Phe
210 215 220

Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile Ser Tyr Pro Leu Ser
225 230 235 240

Leu His His Lys Gly Tyr Lys Glu Ile Glu Arg Phe Met Lys Glu Arg
245 250 255

Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser Phe Tyr
260 265 270

Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Leu Gln Ser Ser Met
275 280 285

Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr Ile Trp Lys Met Glu
290 295 300

Arg Gly Asn His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp Thr Ala
305 310 315 320

Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val Ser Lys Asp Asn Lys
325 330 335

Met Ile Gln Asn Ala Thr Ala Tyr Leu Leu Lys Lys Gln His Thr Lys
340 345 350

Lys Ala Asp Trp Ser Val His Ala Gln Ala Leu Thr Pro Gly Gly Trp
355 360 365

Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp Asp Thr Thr
370 375 380

Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Lys Asn Ile Asp
385 390 395 400

Asn Ala Trp Lys Lys Gly Val Asn Trp Ile Lys Gly Leu Gln Asn Asn
405 410 415

Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Lys Leu Leu
420 425 430

Ala Lys Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp Pro Ser
435 440 445

Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe Phe Gly Thr Tyr Ala
450 455 460

Gln Asn Glu Leu Pro Glu Lys Gln Ile Gln Arg Ala Ile Asn Trp Leu
465 470 475 480

Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp Gly Ile
485 490 495

Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr Gly Leu Arg Ser Leu
500 505 510

Gly Ile Pro Ser Ser Asn Pro Ser Leu Thr Arg Ala Ala Ser Trp Leu
515 520 525

Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys His Ser
530 535 540

Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro Ser Gln
545 550 555 560

Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Asp Thr Glu Thr
565 570 575

Pro Ala Ile Arg Lys Gly Val Ser Tyr Leu Leu Ser Asn Pro Tyr Val
580 585 590

Asn Glu Arg Tyr Pro Thr Gly Thr Gly Leu Pro Gly Ala Phe Tyr Ile
595 600 605

Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu Leu Thr Leu Ala His
610 615 620

Tyr Ile Lys Lys Tyr Arg Lys
625 630


<210> 63
<211> 653
<212> PRT
<213> Bacillus thuringiensis

<400> 63
Met Ser Asn Leu Leu Leu Tyr Glu Lys Ala His Glu Glu Ile Ala Arg
1 5 10 15

Arg Ala Thr Ala Leu Gln Thr Met Gln Arg Glu Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Thr Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Gly Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Asn Phe Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Val Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Glu
195 200 205

Arg Ser Pro Leu Phe Gln Thr Leu Leu Ser Asp Val Lys Gln Ile Ile
210 215 220

Ser Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Leu Gln Ser Ser Met Ile Gln Lys Ala Ile Ala Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Ser Gly Asn His Val Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala His Val
305 310 315 320

Pro Lys Asp Asn Lys Met Leu Gln Asn Ala Thr Ala Tyr Leu Leu Lys
325 330 335

Lys Gln His Thr Lys Lys Ala Asp Trp Ser Val His Ala Pro Ala Leu
340 345 350

Thr Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Val Pro Asp
355 360 365

Val Asp Asp Thr Thr Ala Val Leu Arg Val Leu Ala Arg Ser Lys Gly
370 375 380

Asn Glu Lys Leu Asp His Ala Trp Gln Lys Gly Ile Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Ala Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Phe Gly Ile Pro Ser Ser Asn Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Lys Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Thr Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ala Asn Pro Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Thr His Tyr Ile Lys Asn Ile Glu Asn Lys Pro Arg Asp
610 615 620

Ile Ser Arg Phe Ile Phe Leu Gly Ser Arg Ser Leu Leu Lys Arg Ile
625 630 635 640

Arg Leu Cys Phe Pro Tyr Phe Ser Val Asp Trp Arg Phe
645 650


<210> 64
<211> 620
<212> PRT
<213> Bacillus thuringiensis

<400> 64
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Ala Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Met Phe Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Val Phe Gln Thr Leu Leu Ser Asp Val Lys Lys Ile Ile
210 215 220

Thr Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Glu Lys Ala Ile Thr Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Ile Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val
305 310 315 320

Pro Lys Ala Ser Lys Val Ile His Asn Ala Ser Ala Tyr Leu Leu Arg
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asp Leu
340 345 350

Phe Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Glu Asn Val Asp Asn Ala Trp Lys Arg Ala Val Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Thr Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Met Thr
485 490 495

Gly Leu Arg Ser Phe Gly Ile Pro Ser Ser Asn Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ser Asn Ser Tyr Ile Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ala Lys Lys Tyr Lys Lys
610 615 620


<210> 65
<211> 620
<212> PRT
<213> Bacillus thuringiensis

<400> 65
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val Tyr Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Met Phe Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Val Phe Gln Thr Leu Val Ser Asp Val Lys Lys Ile Ile
210 215 220

Thr Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Gly Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Glu Lys Ala Ile Met Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Ile Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val
305 310 315 320

Pro Lys Val Ser Lys Val Ile Gln Asn Ala Ser Ala Tyr Leu Leu Arg
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asp Leu
340 345 350

Phe Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Glu Asn Val Asp Asn Ala Trp Lys Arg Ala Val Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Thr Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asp Ser Ser Leu Lys Arg
500 505 510

Ala Val Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ser Asn Pro Tyr Ile Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ala Lys Lys Tyr Arg Lys
610 615 620


<210> 66
<211> 620
<212> PRT
<213> Bacillus thuringiensis

<400> 66
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Gln
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Met Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Asn Phe Ile Lys Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Val Phe Gln Thr Leu Ala Ser Asp Val Lys Lys Ile Ile
210 215 220

Thr Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Glu Lys Ala Ile Met Gly Ile Thr Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Ile Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val
305 310 315 320

Pro Lys Ala Ser Lys Val Ile Gln Asn Ala Ser Ala Tyr Leu Leu Arg
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asp Leu
340 345 350

Phe Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asn Glu Asn Val Asp Asn Ala Trp Lys Arg Ala Val Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Gly Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Thr Asn Ala Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asp Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys His Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Asp Lys Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ser Asn Pro Tyr Ile Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Cys Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Ala Lys Lys Tyr Arg Lys
610 615 620


<210> 67
<211> 620
<212> PRT
<213> Bacillus thuringiensis

<400> 67
Met Ser Asn Leu Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg
1 5 10 15

Arg Thr Thr Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg
20 25 30

Phe Cys Phe Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu
35 40 45

Leu Lys Leu Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg
50 55 60

Leu Ala Ser Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp
65 70 75 80

Glu Val Gly Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu
85 90 95

Leu Ala Ser Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala
100 105 110

Glu Met Phe Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met
115 120 125

Thr Lys Phe Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu
130 135 140

Phe His Leu Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu
145 150 155 160

Ser Ile Phe Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met
165 170 175

Met Leu Cys Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro
180 185 190

Asn Leu Asn His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp
195 200 205

Arg Ser Pro Val Phe Gln Thr Leu Leu Ser Glu Val Lys Lys Ile Ile
210 215 220

Thr Tyr Pro Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg
225 230 235 240

Phe Met Lys Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala
245 250 255

Thr Ala Ser Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser
260 265 270

Ile Gln Ser Pro Ile Ile Gln Lys Ala Ile Thr Gly Ile Ala Ser Tyr
275 280 285

Ile Trp Lys Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr
290 295 300

Val Trp Asp Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val
305 310 315 320

Pro Lys Ala Ser Lys Val Ile Gln Asn Ala Ser Ala Tyr Leu Leu Arg
325 330 335

Lys Gln Gln Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asn Leu
340 345 350

Phe Pro Gly Gly Trp Gly Phe Ser Asp Val Asn Thr Met Ile Pro Asp
355 360 365

Ile Asp Asp Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly
370 375 380

Asp Glu Asn Val Asp Asn Ala Trp Lys Arg Ala Val Asn Trp Val Lys
385 390 395 400

Gly Leu Gln Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val
405 410 415

Thr Ser Arg Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met
420 425 430

Ile Thr Asp Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe
435 440 445

Phe Gly Thr Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser
450 455 460

Ala Ile Asn Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr
465 470 475 480

Gly Lys Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr
485 490 495

Gly Leu Arg Ser Leu Gly Ile Pro Ser Ser Asp Pro Ser Leu Lys Arg
500 505 510

Ala Ala Leu Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly
515 520 525

Glu Ser Cys Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe
530 535 540

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr
545 550 555 560

Tyr Glu Lys Glu Thr Pro Ile Ile Arg Lys Gly Ile Ser Tyr Leu Leu
565 570 575

Ser Asn Pro Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro
580 585 590

Gly Gly Phe Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu
595 600 605

Leu Thr Leu Ala His Tyr Thr Lys Lys Tyr Arg Lys
610 615 620


<210> 68
<211> 617
<212> PRT
<213> Bacillus thuringiensis

<400> 68
Met Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg Arg Thr Thr
1 5 10 15

Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu
35 40 45

Leu Gly Lys Asp Lys Glu Ile Glu Pro Phe Val Lys Arg Leu Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Glu Lys Tyr Thr Lys Glu Asp Val Asn Met Lys Arg Ala Glu Met Phe
100 105 110

Ile Asn Glu His Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Ile His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Leu
130 135 140

Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys
165 170 175

Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn
180 185 190

His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro
195 200 205

Val Phe Gln Thr Leu Val Ser Asp Val Lys Lys Ile Ile Thr Tyr Pro
210 215 220

Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg Phe Met Lys
225 230 235 240

Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser
245 250 255

Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Ile Gln Ser
260 265 270

Pro Ile Ile Gln Lys Ala Ile Thr Gly Ile Thr Ser Tyr Ile Trp Lys
275 280 285

Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp
290 295 300

Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val Pro Lys Ala
305 310 315 320

Ser Lys Val Ile His Asn Ala Ser Ala Tyr Leu Leu Arg Lys Gln Gln
325 330 335

Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asp Leu Phe Pro Gly
340 345 350

Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp Asp
355 360 365

Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Glu Asn
370 375 380

Val Asp Thr Ala Trp Lys Arg Ala Val Asn Trp Val Lys Gly Leu Gln
385 390 395 400

Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Arg
405 410 415

Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe Phe Gly Thr
435 440 445

Tyr Thr Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser Ala Ile Asn
450 455 460

Trp Leu Met Asn Val Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp
465 470 475 480

Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr Gly Leu Arg
485 490 495

Ser Leu Gly Ile Pro Ser Ser Asp Pro Ser Val Lys Arg Ala Ala Leu
500 505 510

Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys
515 520 525

Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro
530 535 540

Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Asp Lys
545 550 555 560

Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ser Asn Ser
565 570 575

Tyr Ile Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro Gly Gly Phe
580 585 590

Tyr Ile Arg Tyr His Ser Tyr Ala His Ile Tyr Pro Leu Leu Thr Leu
595 600 605

Ala His Tyr Ala Lys Lys Tyr Arg Lys
610 615


<210> 69
<211> 617
<212> PRT
<213> Bacillus thuringiensis

<400> 69
Met Leu Leu Tyr Glu Lys Val His Glu Glu Ile Ala Arg Arg Thr Thr
1 5 10 15

Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Arg Phe Cys Phe
20 25 30

Glu Gly Ala Pro Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu
35 40 45

Leu Gly Arg Asp Lys Glu Ile Glu Pro Phe Val Lys Arg Leu Ala Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Val Gly
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ser Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Glu Lys Tyr Thr Lys Glu Asp Ala Asn Met Lys Arg Ala Glu Met Phe
100 105 110

Ile Asn Glu Arg Gly Gly Val Ala Arg Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Val His Gly Glu Tyr Glu Tyr Pro Ser Leu Phe His Leu
130 135 140

Pro Thr Pro Ile Met Phe Leu Gln Asn Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Glu Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Leu Cys
165 170 175

Leu Asn Lys Arg Phe Arg Val Gly Lys Lys Leu Leu Pro Asn Leu Asn
180 185 190

His Ile Ala Gly Gly Gly Gly Glu Trp Phe Arg Glu Asp Arg Ser Pro
195 200 205

Val Phe Gln Thr Leu Leu Ser Glu Val Lys Lys Ile Ile Thr Tyr Pro
210 215 220

Leu Ser Leu His His Lys Gly Tyr Glu Ala Val Glu Arg Phe Met Lys
225 230 235 240

Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Thr Ala Ser
245 250 255

Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Ile Gln Ser
260 265 270

Pro Ile Ile Gln Lys Ala Ile Thr Gly Ile Thr Ser Tyr Ile Trp Lys
275 280 285

Met Glu Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp
290 295 300

Thr Ala Leu Leu Ser Tyr Ala Leu Gln Glu Ala Gln Val Pro Lys Ala
305 310 315 320

Ser Lys Gly Ile Gln Asn Ala Ser Ala Tyr Leu Leu Arg Lys Gln Gln
325 330 335

Thr Lys Lys Val Asp Trp Ser Val His Ala Pro Asp Leu Phe Pro Gly
340 345 350

Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp Asp
355 360 365

Thr Thr Ala Val Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Glu Asn
370 375 380

Val Asp Asn Ser Trp Lys Arg Ala Val Asn Trp Val Lys Gly Leu Gln
385 390 395 400

Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Lys Gly Val Thr Ser Arg
405 410 415

Ile Leu Ala Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Pro Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Phe Phe Gly Thr
435 440 445

Tyr Ala Gln Asn Glu Leu Pro Glu Lys Gln Lys Gln Ser Ala Ile Asn
450 455 460

Trp Leu Met Asn Ile Gln Glu Glu Asn Gly Ser Trp Tyr Gly Lys Trp
465 470 475 480

Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Val Leu Thr Gly Leu Arg
485 490 495

Ser Leu Gly Ile Pro Ser Ser Asp Pro Ser Leu Lys Arg Ala Ala Leu
500 505 510

Trp Leu Glu His Ile Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys
515 520 525

Gln Ser Ser Val Glu Lys Arg Phe Val Thr Leu Pro Phe Ser Thr Pro
530 535 540

Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Glu Lys
545 550 555 560

Glu Thr Pro Val Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ser Asn Pro
565 570 575

Tyr Val Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro Gly Gly Phe
580 585 590

Tyr Ile Arg Tyr His Ser Tyr Thr His Ile Tyr Pro Leu Leu Thr Leu
595 600 605

Ala His Tyr Ala Lys Lys Tyr Arg Lys
610 615


<210> 70
<211> 617
<212> PRT
<213> Bacillus weihenstephanensis

<400> 70
Met Leu Leu Tyr Asp Lys Val His Glu Glu Ile Glu Arg Arg Thr Thr
1 5 10 15

Ala Leu Gln Thr Met Gln Arg Gln Asp Gly Thr Trp Gln Phe Cys Phe
20 25 30

Glu Gly Ala Leu Leu Thr Asp Cys His Met Ile Phe Leu Leu Lys Leu
35 40 45

Leu Gly Arg Asn Asp Glu Ile Glu Pro Phe Val Lys Arg Leu Val Ser
50 55 60

Leu Gln Thr Asn Glu Gly Thr Trp Lys Leu Tyr Glu Asp Glu Lys Gly
65 70 75 80

Gly Asn Leu Ser Ala Thr Ile Gln Ala Tyr Ala Ala Leu Leu Ala Ser
85 90 95

Glu Lys Tyr Ser Lys Glu Asp Met Asn Met Arg Arg Ala Glu Met Phe
100 105 110

Ile Lys Glu His Gly Gly Val Ser Arg Ala His Phe Met Thr Lys Phe
115 120 125

Leu Leu Ala Ile His Gly Glu Tyr Glu Phe Pro Ala Leu Phe His Phe
130 135 140

Pro Thr Pro Ile Leu Phe Leu Gln Asp Asp Ser Pro Leu Ser Ile Phe
145 150 155 160

Gly Leu Ser Ser Ser Ala Arg Ile His Leu Ile Pro Met Met Ile Cys
165 170 175

Met Asn Lys Arg Phe Arg Val Glu Lys Lys Leu Leu Pro Asn Leu Asn
180 185 190

His Ile Ala Gly Gly Gly Gly Gln Trp Phe Arg Glu Glu Arg Ser Pro
195 200 205

Leu Ile Gln Ser Phe Leu Gly Asp Val Lys Lys Val Ile Ser Tyr Pro
210 215 220

Leu Ser Leu His His Lys Gly Tyr Glu Glu Val Glu Arg Phe Met Lys
225 230 235 240

Glu Arg Ile Asp Glu Asn Gly Thr Leu Tyr Ser Tyr Ala Ser Ala Thr
245 250 255

Phe Tyr Met Ile Tyr Ala Leu Leu Ala Leu Gly His Ser Ile Gln Ser
260 265 270

Pro Ile Ile Glu Lys Ala Val Thr Gly Leu Lys Ser Tyr Ile Trp Lys
275 280 285

Met Asp Arg Gly Ser His Leu Gln Asn Ser Pro Ser Thr Val Trp Asp
290 295 300

Thr Ala Leu Leu Ser Tyr Ser Leu Gln Glu Ala Lys Val Thr Asn Glu
305 310 315 320

Asn Lys Met Ile Gln Arg Ala Thr Glu Tyr Leu Leu Gln Lys Gln Gln
325 330 335

Thr Lys Lys Val Asp Trp Ser Val His Ala Ser Ser Leu Val Ala Gly
340 345 350

Gly Trp Gly Phe Ser Asp Val Asn Thr Thr Ile Pro Asp Ile Asp Asp
355 360 365

Thr Thr Ala Ala Leu Arg Ala Leu Ala Arg Ser Arg Gly Asn Asp Arg
370 375 380

Val Asp Asp Ala Trp Gly Arg Gly Val Glu Trp Val Lys Gly Leu Gln
385 390 395 400

Asn Asn Asp Gly Gly Trp Gly Ala Phe Glu Arg Gly Val Thr Ser Lys
405 410 415

Leu Leu Ser Asn Leu Pro Ile Glu Asn Ala Ser Asp Met Ile Thr Asp
420 425 430

Pro Ser Thr Pro Asp Ile Thr Gly Arg Val Leu Glu Leu Phe Gly Thr
435 440 445

Tyr Ala Pro Asn Glu Leu Leu Glu Glu Gln Lys Lys Lys Ala Ile Lys
450 455 460

Trp Leu Met Asp Val Gln Glu Gln Asn Gly Ser Trp Tyr Gly Lys Trp
465 470 475 480

Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Thr Met Thr Gly Leu Arg
485 490 495

Ala Leu Gly Val Pro Ser Thr His Pro Ala Leu Lys Lys Ala Ala Ser
500 505 510

Trp Leu Glu His Leu Gln His Glu Asp Gly Gly Trp Gly Glu Ser Cys
515 520 525

Gln Ser Ser Val Glu Lys Lys Phe Ile Ser Leu Pro Phe Ser Thr Pro
530 535 540

Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ser Tyr Tyr Asp Gln
545 550 555 560

Glu Thr Pro Ile Ile Arg Lys Gly Ile Ser Tyr Leu Leu Ala Gln Ser
565 570 575

Thr Met Asn Glu Lys Tyr Pro Thr Gly Thr Gly Leu Pro Gly Gly Phe
580 585 590

Tyr Ile Arg Tyr His Ser Tyr Gly His Ile Tyr Pro Leu Leu Ala Leu
595 600 605

Ala His Tyr Val Lys Lys Tyr Arg Lys
610 615


<210> 71
<211> 698
<212> PRT
<213> Bacterium Ellin514

<400> 71
Met Ile Lys Asn Phe Thr Ala Leu Trp Pro Ile Arg Arg Val Lys Gly
1 5 10 15

Val Ser Val Thr Ser Gln Asp Gly His Ser Ala Asn Gly Ala Ser Lys
20 25 30

Pro Asp Phe Glu Val Arg Pro His Val Asp Leu Glu Thr Ala Ile His
35 40 45

Arg Ser Gln Ser Phe Leu Leu Lys Glu Gln Lys Pro Glu Gly Tyr Trp
50 55 60

Val Gly Glu Leu Ile Val Asp Ser Thr Leu Val Ser Asp Thr Ile Ala
65 70 75 80

Tyr His His Trp Asn Gly Lys Val Asp Met Glu Trp Gln Arg Lys Ala
85 90 95

Val Asn His Ile Phe Ser Met Gln Leu Pro Asp Gly Gly Trp Asn Ile
100 105 110

Tyr Tyr Gly Gly Pro Ala Glu Ile Asn Ala Thr Val Lys Ala Tyr Leu
115 120 125

Ala Leu Lys Leu Ala Gly Val Pro Val Met Asp Pro Arg Met Leu Arg
130 135 140

Ala Arg Ser Val Ala Leu Ser Met Gly Gly Val Pro Arg Met Asn Thr
145 150 155 160

Phe Ser Lys Leu Tyr Leu Ala Leu Leu Gly Leu Phe Pro Trp Asn Tyr
165 170 175

Val Pro Thr Ile Pro Cys Glu Val Ile Leu Ile Gly Lys Trp Phe His
180 185 190

Val Asn Phe Tyr Glu Met Ser Ser Trp Ser Arg Ser Met Leu Val Pro
195 200 205

Leu Ala Ile Ile Asn His Phe Lys Pro Thr Arg Lys Leu Gln Asn Gln
210 215 220

Val Lys Leu Asp Glu Leu Tyr Pro Glu Gly Tyr His Glu Arg Asp Leu
225 230 235 240

Ala Leu Pro Pro Asp Pro Glu Phe Leu Thr Phe Arg Asn Phe Phe Leu
245 250 255

Trp Leu Asp Lys Leu His Lys Phe Ala Glu Leu Trp Val Gln Ala Gly
260 265 270

Ile His Pro Phe Arg Arg Arg Ala Leu Lys Lys Cys Glu His Trp Met
275 280 285

Leu Glu Arg Phe Glu Gly Ser Asn Gly Leu Ala Ala Ile Phe Pro Ala
290 295 300

Met Leu Asn Ser Leu Ile Ala Leu Lys Ala Leu Gly Tyr Pro Gly Asp
305 310 315 320

His Pro Glu Val Lys Arg Ala Glu Lys Glu Leu Lys Asn Leu Glu His
325 330 335

Glu Thr Ala Asp Thr Val Arg Ile Glu Pro Cys Phe Ser Pro Val Trp
340 345 350

Asp Thr Ala Ile Val Ala Ile Cys Leu His Glu Ser Gly Ile Pro Ser
355 360 365

Asp His Pro Ala Leu Lys Lys Ser Ala Glu Trp Leu Ile Asp Lys Glu
370 375 380

Ile Arg Phe Arg Gly Asp Trp Tyr Phe Lys Asn Pro Val Asp Val Glu
385 390 395 400

Pro Ser Gly Trp Val Phe Glu Phe Glu Asn Lys Trp Asn Pro Asp Val
405 410 415

Asp Asp Thr Ala Met Val Leu Leu Ala Leu Arg Lys Ile Pro Thr Ser
420 425 430

Asp Val Lys Arg Arg Asp Glu Cys Phe Gln Arg Gly Leu Lys Trp Met
435 440 445

Met Ala Phe Gln Cys Lys Asp Gly Gly Trp Ala Ala Phe Asp Lys Asp
450 455 460

Cys Thr Lys Gly Ile Leu Glu Lys Val Pro Phe Ala Asp His Asn Ala
465 470 475 480

Met Leu Asp Pro Glu Cys Ala Asp Ile Thr Ala Arg Ile Leu Glu Leu
485 490 495

Leu Gly Tyr Glu Gly Val Gly Val Asp His Pro Gln Ile Lys Lys Ala
500 505 510

Leu Gln Phe Ile Gln Glu Glu Gln Glu Asp Asp Gly Ser Trp Tyr Gly
515 520 525

Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Gln Val Leu Arg Gly
530 535 540

Leu Arg Ala Leu Asn Ile Asn Met Asn Gln Pro Trp Leu Leu Lys Ala
545 550 555 560

Arg Asp Trp Leu Glu Ser Val Gln His Glu Asp Gly Gly Trp Gly Glu
565 570 575

Arg Cys Asn Thr Tyr Asp Asp Pro Val Phe Lys Gly Gln Gly Pro Ser
580 585 590

Thr Ala Ser Gln Thr Ala Trp Ala Val Met Gly Leu Cys Thr Phe Asp
595 600 605

Asp Pro Gln Arg Pro Ser Leu Met Arg Gly Ile Asp Tyr Leu Ile Lys
610 615 620

Thr Gln Asn Ser Asp Gly Ser Trp Thr Glu His Glu Ile Thr Gly Thr
625 630 635 640

Gly Phe Pro Arg Val Phe Tyr Leu Lys Tyr Asp Met Tyr Arg Asn Ser
645 650 655

Trp Pro Leu Leu Ala Leu Ala Thr Tyr Arg Asn Leu Tyr Ala Ser Ser
660 665 670

Glu Lys Thr Ala Asn Gly His Thr Asn Gly His Ser Val Gln Leu Pro
675 680 685

Glu Ala Leu Lys Thr Pro Pro Ala Phe Lys
690 695


<210> 72
<211> 651
<212> PRT
<213> Bacterium Ellin514

<400> 72
Met Lys Ser Glu Glu Val Thr Ile Lys Pro Ala Val Gly Leu Glu Lys
1 5 10 15

Asp Glu Leu Asn Ala Ala Ile Thr Arg Ser Gln Ser Phe Leu Leu Cys
20 25 30

Glu Gln Lys Pro Glu Gly Tyr Trp Val Gly Glu Leu Met Val Asp Ser
35 40 45

Thr Ile Val Ser Asp Thr Ile Ala Tyr His His Trp Asn Gly Lys Val
50 55 60

Asp Pro Glu Trp Gln Arg Lys Ala Val Asn His Ile Leu Ser Met Gln
65 70 75 80

Leu Pro Glu Gly Gly Trp Asn Ile Tyr Gln Asn Gly Pro Pro Glu Val
85 90 95

Asn Ala Thr Ile Lys Ala Tyr Leu Ala Leu Lys Leu Ala Gly Ile Pro
100 105 110

Ile Thr Asp Pro Arg Met Leu Lys Ala Arg Gln Val Ala Leu Thr Leu
115 120 125

Gly Gly Val Pro Arg Met Asn Thr Phe Ser Lys Leu Tyr Leu Ala Leu
130 135 140

Leu Gly Leu Trp Pro Trp Lys Tyr Val Pro Thr Ile Pro Cys Glu Val
145 150 155 160

Leu Leu Leu Gly Lys Trp Phe His Val Asn Ile Trp Asp Met Ser Asn
165 170 175

Trp Ser Arg Ala Met Ile Val Pro Leu Ala Ile Ile Asn His Tyr Lys
180 185 190

Pro Thr Arg Pro Val Lys Val Asp Leu Ser Glu Leu Phe Leu Glu Gly
195 200 205

Phe His Glu Arg Asp Leu Ala Leu Pro Lys Asp Pro Gln Ser Phe Thr
210 215 220

Trp Arg Asn Phe Phe Leu Gly Leu Asp Gln Leu His Lys Phe Ala Glu
225 230 235 240

Leu Trp Val Asn Ala Gly Ile His Pro Phe Arg Arg Leu Ala Leu Lys
245 250 255

Lys Cys Glu Gln Trp Met Leu Glu Arg Phe Glu Gly Ser Asp Gly Leu
260 265 270

Ala Ala Ile Phe Pro Ala Met Leu Asn Ser Leu Ile Ala Leu Lys Ser
275 280 285

Leu Gly Tyr Pro Asp Asp His Pro Glu Val Leu Arg Ala Glu Arg Glu
290 295 300

Leu Lys Lys Leu Glu His Glu Thr Lys Asp Thr Val Arg Ile Glu Pro
305 310 315 320

Cys Leu Ser Pro Gly Trp Asp Thr Ala Ile Ala Ala Met Cys Leu Arg
325 330 335

Glu Ser Gly Val Pro Ala Glu His Pro Arg Leu Lys Lys Ala Gly Asp
340 345 350

Trp Leu Val Asn Arg Glu Val Arg Phe Lys Ala Asp Trp His His Lys
355 360 365

Asn Pro Val Asp Val Glu Pro Ser Gly Trp Val Phe Gln Phe Asn Asn
370 375 380

Lys Trp Asn Pro Asp Leu Asp Asp Thr Ala Met Val Leu Leu Ala Leu
385 390 395 400

Arg Leu Ile Pro Thr Asp His Pro Arg Arg Arg Asp Glu Ala Phe Gln
405 410 415

Arg Gly Leu Lys Trp Leu Leu Ala Phe Gln Cys Arg Asp Gly Gly Trp
420 425 430

Ala Ala Tyr Asp Lys Asp Cys Thr Lys Asn Ile Leu Glu Lys Val Pro
435 440 445

Phe Ala Asp His Asn Ala Met Leu Asp Pro Glu Cys Ala Asp Ile Thr
450 455 460

Ala Arg Val Leu Glu Leu Leu Gly Phe Glu Gly Tyr Ala Leu Asp His
465 470 475 480

Pro Gln Val Gln Glu Ala Val Glu Tyr Leu Arg Glu His Gln Glu Thr
485 490 495

Asp Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr
500 505 510

Trp Gln Thr Leu Arg Gly Leu Trp Ala Leu Lys Met Asp Met Asn Gln
515 520 525

Pro Trp Leu Leu Lys Ala Arg Asp Trp Leu Glu Ser Val Gln Leu Pro
530 535 540

Asp Gly Gly Trp Gly Glu Arg Cys Asn Thr Tyr Asp Asp Pro Val Phe
545 550 555 560

Lys Gly Gln Gly Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Val Met
565 570 575

Ala Leu Cys Thr Phe Gly Asp Pro Lys Arg Pro Ser Leu Val Arg Gly
580 585 590

Ile Gln Tyr Leu Ile Glu Asn Gln Asn Glu Asp Gly Ser Trp Thr Glu
595 600 605

Leu Glu Thr Thr Gly Thr Gly Phe Pro Arg Val Tyr Tyr Leu Lys Tyr
610 615 620

Asp Ile Tyr Arg Asn Thr Trp Pro Leu Leu Ala Met Ala Thr Tyr Arg
625 630 635 640

Lys Met Leu Asp Pro Lys Glu Val Arg Val Lys
645 650


<210> 73
<211> 662
<212> PRT
<213> Beijerinckia indica

<400> 73
Met Pro Glu Glu Ala Ile Leu Thr Glu Thr His Pro Leu Asp Ala Thr
1 5 10 15

Thr Ile Glu Thr Ala Ile Thr Arg Ala Arg Lys Ala Leu Leu Gly Glu
20 25 30

Gln Arg Ala Asp Gly His Phe Val Phe Glu Leu Glu Ala Asp Val Ser
35 40 45

Ile Pro Cys Glu Tyr Ile Leu Phe Tyr His Phe Ile Gly Arg Pro Ala
50 55 60

Pro Ala Glu Leu Glu Ala Lys Ile Gly His Tyr Leu Arg Ala Arg Gln
65 70 75 80

Ser Ala Glu His Asp Gly Trp Pro Leu Phe Gln Asp Gly Ala Phe Asn
85 90 95

Ile Ser Ser Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ile Gly Asp
100 105 110

Thr Pro Asp Met Pro His Met Gln Arg Ala Arg Thr Ala Ile Leu Ala
115 120 125

His Gly Gly Ala Ala Ala Ala Asn Val Phe Thr Arg Ser Leu Leu Ala
130 135 140

Leu Phe Gly Leu Ile Pro Trp His Gly Ile Pro Val Met Pro Ile Glu
145 150 155 160

Ile Met His Leu Pro Glu Trp Phe Pro Phe His Ile Ala Lys Ile Ser
165 170 175

Tyr Trp Gly Arg Thr Val Leu Val Pro Met Met Val Val His Ala Leu
180 185 190

Lys Pro Lys Pro Ala Asn Thr Cys Thr Ile Arg Ile Asp Glu Leu Phe
195 200 205

Val Ile Pro Pro Asp Gln Val Arg His Trp Pro Gly Ser Pro Gly Lys
210 215 220

Arg Phe Pro Trp Thr Ala Ile Phe Ala Gly Ile Asp Lys Val Leu Gln
225 230 235 240

Ile Ala Glu Pro Tyr Phe Pro Arg Arg Ser Arg Gln Ser Ala Ile Asp
245 250 255

Lys Ala Val Ala Phe Val Thr Lys Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Tyr Ser Ala Leu Met Tyr Leu Ser
275 280 285

Ile Gly Arg Ser Leu Ser Asp Pro His Ile Gln Leu Val Leu Lys Ala
290 295 300

Ile Asp Lys Leu Val Val Val Lys Asp His Glu Ala Tyr Val Gln Pro
305 310 315 320

Cys Val Ser Pro Val Trp Asp Thr Ala Leu Ala Ser His Ala Leu Met
325 330 335

Glu Ala Gly Asp Gly Asp Lys Pro Ile Leu Asp Ser Leu Lys Lys Gly
340 345 350

Leu Ala Trp Leu Lys Pro Leu Gln Val Thr Asp Ile Ala Gly Asp Trp
355 360 365

Ala Trp Lys Lys Pro Asp Val Lys Pro Gly Gly Trp Ala Phe Gln Tyr
370 375 380

Gly Asn Ala Tyr Tyr Pro Asp Leu Asp Asp Thr Ala Val Val Val Met
385 390 395 400

Ala Met Asp Arg Ala Arg Asp Arg Trp Pro Glu Ile Asp Glu Asp Asn
405 410 415

Phe Arg Pro Ser Ile Ala Arg Ala Arg Glu Trp Ile Val Gly Leu Gln
420 425 430

Ser Glu Asn Gly Gly Phe Gly Ala Phe Asp Ala Asp Asn Asp Arg Asp
435 440 445

Tyr Leu Asn Ala Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro
450 455 460

Pro Thr Ala Asp Val Thr Ala Arg Cys Ile Ser Met Leu Thr Gln Leu
465 470 475 480

Gly Glu Lys Pro Glu Asn Ser Glu Thr Leu Arg Arg Ala Ile Ala Tyr
485 490 495

Leu Phe Ala Glu Gln Glu Lys Asp Gly Ser Trp Phe Gly Arg Trp Gly
500 505 510

Leu Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ser Leu Asn Ala
515 520 525

Ala Gly Ile Ala His Asp Ala Pro Glu Val Arg Arg Ala Val Ala Trp
530 535 540

Leu Arg Thr Ile Gln Asn Glu Asp Gly Gly Trp Gly Glu Asp Ala Glu
545 550 555 560

Ser Tyr Ala Leu Asp Tyr Ala Gly Tyr Gln Gln Ala Pro Ser Thr Ser
565 570 575

Ser Gln Thr Ala Trp Ala Val Leu Gly Leu Met Ala Ala Gly Glu Lys
580 585 590

Asp Asp Pro Ala Val Ala Arg Gly Ile Ala Tyr Leu Thr Arg Thr Gln
595 600 605

Gly Glu Asp Gly Phe Trp Thr Glu Lys Arg Phe Thr Ala Thr Gly Phe
610 615 620

Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Ser Lys Phe Phe Pro
625 630 635 640

Leu Trp Ala Met Ala Arg Tyr Arg Asn Leu His Asn Gly Asn His Ala
645 650 655

Ser Val Leu Thr Gly Met
660


<210> 74
<211> 691
<212> PRT
<213> Blastopirellula marina

<400> 74
Met Glu Gly Ala Ser Pro Thr Ala Ser Asn Arg Ile Ser Gln Tyr Ala
1 5 10 15

Val Asp Leu Arg Ala Lys Ala Arg Ala Ala Val Ala Ser Thr Cys Asp
20 25 30

Trp Leu Leu Ser His Gln His Ala Asp Gly His Trp Cys Ala Glu Leu
35 40 45

Glu Gly Asp Ser Ile Leu Gln Ser Glu Tyr Ile Leu Leu Leu Ala Trp
50 55 60

Leu Gly Lys Glu Arg Thr Glu Ile Ala Arg Arg Cys Ala Ala His Leu
65 70 75 80

Leu Lys Gln Gln Glu Pro Asn Gly Ala Trp Thr Gln Phe Pro Gly Ala
85 90 95

Pro Ile Asp Val Gly Ser Ser Val Lys Ala Tyr Phe Ala Leu Lys Leu
100 105 110

Thr Gly His Asp Ala Ala Ala Asp Tyr Met Val Arg Ala Arg Asn Ala
115 120 125

Ile Leu Glu Ala Gly Gly Ala Asp Lys Val Asn Ser Phe Thr Arg Phe
130 135 140

Tyr Leu Ala Leu Leu Gly Gln Ile Pro Phe Glu Leu Cys Pro Ala Val
145 150 155 160

Pro Pro Glu Met Val Leu Leu Pro Asn Trp Ser Pro Ile Asn Ile Tyr
165 170 175

Arg Ile Ser Ser Trp Ser Arg Thr Ile Phe Val Pro Leu Ser Ile Val
180 185 190

Trp Ala His Arg Ala Ala Arg Asp Ile Val Glu Asp Val Ser Ile His
195 200 205

Glu Leu Phe Ile Arg Lys Pro Glu Asp Trp Pro Glu Leu Arg Cys Pro
210 215 220

Gly Leu Glu Lys Pro Ala Gly Leu Phe Ser Trp Asp Arg Phe Phe Arg
225 230 235 240

Thr Ala Asp Ser Gly Leu Lys Leu Leu Glu Lys Tyr Gly Leu Arg Pro
245 250 255

Leu Arg Lys Arg Ala Leu Arg Gln Ala Gln Gln Trp Met Leu Asp Arg
260 265 270

Phe Gln Gln Ser Asp Gly Pro Gly Ala Ile Phe Pro Pro Ile Val Trp
275 280 285

Ser Ala Ile Ala Leu Arg Thr Leu Gly Tyr Ala Glu Asp Ser Pro Glu
290 295 300

Ile Gln Tyr Cys Leu Asp His Leu Glu Arg Leu Val Leu Glu Asp Gly
305 310 315 320

Glu Thr Thr Lys Leu Gln Pro Cys Lys Ser Pro Val Trp Asp Thr Ser
325 330 335

Ile Thr Leu Arg Ala Leu Ala Ala Ala Gly Leu Gly Leu Ala Gln Glu
340 345 350

Pro Thr Cys Arg Gly Val Glu Trp Leu Leu Ser Lys Glu Val Arg Val
355 360 365

Pro Gly Asp Trp Thr Asn Asn Val Asp Cys Glu Pro Gly Gly Trp Phe
370 375 380

Phe Glu Tyr Glu Asn Ala Phe Tyr Pro Asp Asn Asp Asp Thr Ser Met
385 390 395 400

Gly Ile Met Ala Leu Ala Asp Gln Leu Ala Ala Ala Asn Ile Thr Leu
405 410 415

Glu Val His Pro Gly Glu Thr Leu Ala Asn Thr Ser Val Val Val Gly
420 425 430

Gly Arg Gly Ile Ala Glu Gln Leu Ala Gly Ser Ser Ala Ala Met Met
435 440 445

Glu Gln Ala Ala Ala Ala Thr Arg Arg Ala Val Ala Trp Met Val Ala
450 455 460

Met Gln Asn Lys Asp Gly Gly Trp Gly Ala Phe Asp Lys Asn Asn Asp
465 470 475 480

Ala Glu Phe Leu Cys His Val Pro Phe Ala Asp His Asn Ala Met Ile
485 490 495

Asp Pro Ser Thr Pro Asp Leu Ser Ala Arg Val Ile Glu Ser Phe Gly
500 505 510

Arg Leu Gly Val Thr Ile Glu Ser Pro Gly Lys Leu Gly Asp Thr Val
515 520 525

Arg Arg Ala Val Ala Tyr Ile Arg Ala Asn Gln Leu Ser Asp Gly Ser
530 535 540

Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Gln Cys
545 550 555 560

Leu Val Gly Leu Arg Ala Val Gly Val Pro Ala Asn Asp Pro Ala Ile
565 570 575

Glu Gln Gly Lys Leu Trp Leu Leu Ala His Gln Gln Ala Cys Gly Gly
580 585 590

Trp Gly Glu Ser Cys Glu Thr Tyr Glu Asp Pro Ser Leu Arg Gly Gln
595 600 605

Gly Ser Pro Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Ile Ile
610 615 620

Ala Ala Gly Gly Ala Asn Leu Ala Glu Val Val His Gly Val Gln Tyr
625 630 635 640

Leu Met Asp Thr Gln Arg Glu Asp Gly Ala Trp Asp Glu Ile Glu Phe
645 650 655

Thr Gly Thr Gly Phe Pro Arg Val Phe Tyr Leu Lys Tyr His Tyr Tyr
660 665 670

Pro Ile Tyr Phe Pro Leu Leu Ala Leu Ala Glu Trp Asn Arg Ala Thr
675 680 685

Ala Arg Ser
690


<210> 75
<211> 610
<212> PRT
<213> Blastopirellula marina

<400> 75
Met Asp Gln Asp Arg Leu Gln Arg Cys Tyr Ala Ile Ala Arg Asp Asp
1 5 10 15

Leu Leu Ala Gln Arg Asn Gly Gln Gly His Trp Thr Gly Glu Leu Ser
20 25 30

Thr Ser Ala Leu Ser Thr Ala Thr Ala Val Ser Ala Leu Gln Leu Val
35 40 45

Val Arg His Asp Pro Ala Gln Ser Glu Arg Leu Met Pro Leu Ile Glu
50 55 60

Gly Gly Val Arg Tyr Leu Thr Glu His Gln Asn Pro Asp Gly Gly Trp
65 70 75 80

Gly Asp Thr Asp Arg Ser Tyr Ser Asn Ile Ala Thr Thr Met Leu Ala
85 90 95

Val Ala Ala Leu Thr Ile Ala Glu Arg Arg Glu Ala Leu Phe Glu Gln
100 105 110

Leu Ala Phe Ala Glu Asn Tyr Ile Glu Ala Gln Gly Gly Ile Pro Gly
115 120 125

Leu Arg Arg Arg Tyr Gly Lys Asp Lys Thr Phe Ala Val Pro Ile Leu
130 135 140

Thr Asn Tyr Ala Leu Ala Gly Leu Val Asp Trp Arg Glu Val Ser Pro
145 150 155 160

Leu Pro Phe Glu Leu Ala Cys Leu Pro Gln Lys Phe Tyr Lys Leu Val
165 170 175

Lys Leu Pro Val Val Ser Tyr Ala Ile Pro Ala Leu Val Ala Ile Gly
180 185 190

Gln Ala Arg Tyr Phe His Arg Pro Pro Phe Asn Pro Leu Met Arg Gly
195 200 205

Leu Arg Gly Ala Ala Val Lys Lys Ser Leu Ala Val Leu Glu Arg Met
210 215 220

Gln Pro Ala Ser Gly Gly Tyr Leu Glu Ala Ala Pro Leu Thr Ser Phe
225 230 235 240

Val Val Met Ser Leu Ala Ser Ile Gly Asn Ala Ser His Pro Val Ala
245 250 255

Gln Asn Gly Val Gln Phe Leu Val Asp Ser Val Arg Glu Asp Gly Ser
260 265 270

Trp Pro Ile Asp Ser Asn Leu Ala Asn Trp Val Thr Thr Leu Ser Ile
275 280 285

Ser Ala Leu Ala Thr Gly Gly Asp Asp Ile Ala Glu Leu Asp Cys Leu
290 295 300

Pro Trp Val Leu Ala Asn Gln Tyr Gln Glu Thr His Pro Phe Thr Gly
305 310 315 320

Ala Asp Pro Gly Gly Trp Gly Trp Thr Asp Leu Ser Gly Ser Val Pro
325 330 335

Asp Ala Asp Asp Thr Pro Gly Ala Met Leu Ala Ile Ala His Phe Phe
340 345 350

His Ser Pro Arg Ala Asp Asn Glu Thr Arg Arg Gln Ile Ala Ser Ala
355 360 365

Ala Ile Ser Gly Ala Arg Trp Leu Leu Asp Leu Gln Asn Ser Asp Gly
370 375 380

Gly Trp Pro Thr Phe Cys Ala Gly Trp Gly Thr Gln Pro Phe Asp Arg
385 390 395 400

Ser Gly Ser Asp Leu Thr Ala His Ala Ile Arg Ala Leu His Ala Trp
405 410 415

Arg Ser Glu Leu Gly Asp Leu Pro Val Glu Arg Ala Ile Glu Arg Gly
420 425 430

Leu Arg Tyr Leu Gln Lys Gln Gln Arg Asp Asp Gly Ser Trp Leu Pro
435 440 445

Leu Trp Phe Gly Asn Gln Asp Ile His Asp Asp Glu Asn Pro Ile Tyr
450 455 460

Gly Thr Val Lys Val Leu Leu Ala Tyr Arg Asp Leu Gly Lys Met Ser
465 470 475 480

Ser Glu Thr Ala Gln Arg Gly Ala Ala Trp Leu Ala Ala Arg Gln Asn
485 490 495

Glu Asp Gly Gly Phe Gly Gly Gly Pro Ser Ile Ser Thr Leu Cys Gly
500 505 510

Gly Pro Gly Glu Ser Ser Val Glu Glu Thr Ala Leu Ala Ile Glu Ala
515 520 525

Leu Phe Ala Ala Glu Asn Ser Asn Ile Ser Ala Glu Ile Val Pro Pro
530 535 540

Ala Val Gly Trp Leu Cys Gln Arg Val Glu Glu Gly Ser Tyr Val Asn
545 550 555 560

Cys Thr Pro Ile Gly Phe Tyr Phe Ser Lys Leu Trp Tyr Tyr Glu Lys
565 570 575

Leu Tyr Pro Arg Val Met Thr Val Thr Ser Leu Gly Ala Ala Leu Gln
580 585 590

Ala Asn Ala Ser Val Pro Pro Ala Pro Glu Thr Val Thr Thr Ser Ser
595 600 605

Asp His
610


<210> 76
<211> 660
<212> PRT
<213> Bradyrhizobium japonicum

<400> 76
Met Asp Ser Val Asn Ala Thr Ala Arg Glu Ala Lys Glu Ser Lys Ile
1 5 10 15

Ser Glu Ser Glu Ile Leu Glu Ser Ser Ile Ala Ser Ala Thr Gln Gly
20 25 30

Val Leu Gly Phe Gln Gln Ser Asp Gly His Trp Val Phe Glu Leu Glu
35 40 45

Ala Asp Cys Thr Ile Pro Ala Glu Tyr Val Leu Leu Arg His Tyr Leu
50 55 60

Ala Glu Pro Val Asp Thr Val Leu Glu Ala Lys Ile Gly Asn Tyr Leu
65 70 75 80

Arg Arg Val Gln Gly Ala His Gly Gly Trp Pro Leu Val His Asp Gly
85 90 95

Glu Phe Asp Met Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Met
100 105 110

Ile Gly Asp Ser Ile Asp Ala Pro His Met Val Arg Ala Arg Glu Ala
115 120 125

Ile His Ala Arg Gly Gly Ala Ile His Ser Asn Val Phe Thr Arg Phe
130 135 140

Met Leu Ala Met Phe Gly Ile Val Thr Trp Arg Ala Val Pro Val Leu
145 150 155 160

Pro Ile Glu Ile Met Leu Leu Pro Phe Trp Ser Pro Phe His Ile Asn
165 170 175

Lys Ile Ser Tyr Trp Ala Arg Thr Thr Met Val Pro Leu Met Val Ile
180 185 190

Ala Ala Leu Lys Pro Arg Ala Lys Asn Pro Lys Gly Val Gly Ile Asp
195 200 205

Glu Leu Phe Leu Gln Asp Pro Arg Ser Ile Gly Met Thr Ala Lys Ala
210 215 220

Pro His Gln Ser Met Ala Trp Phe Leu Leu Phe Arg Ser Leu Asp Ala
225 230 235 240

Ile Leu Arg Val Ile Glu Pro Leu Phe Pro Lys Ser Leu Arg Lys Arg
245 250 255

Ala Ile Asp Thr Ala Leu Ala Phe Ser Glu Glu Arg Leu Asn Gly Glu
260 265 270

Asp Gly Met Gly Ala Ile Tyr Pro Pro Met Ala Asn Leu Val Met Met
275 280 285

Tyr Asp Ala Leu Gly Lys Asp Glu Asn Tyr Pro Pro Arg Ala Val Thr
290 295 300

Arg Arg Gly Ile Asp Lys Leu Leu Val Ile Gly Asp Asp Glu Ala Tyr
305 310 315 320

Cys Gln Pro Cys Val Ser Pro Val Trp Asp Thr Thr Leu Thr Ala His
325 330 335

Ala Leu Leu Glu Ala Gly Gly Asp Lys Ala Gly Pro Ala Ala Lys His
340 345 350

Gly Leu Asp Trp Leu Ile Pro Lys Gln Glu Leu Glu Val Lys Gly Asp
355 360 365

Trp Ala Val Lys Arg Pro Asp Val Arg Pro Gly Gly Trp Ala Phe Gln
370 375 380

Tyr Asn Asn Ala Tyr Tyr Pro Asp Leu Asp Asp Thr Ala Val Val Val
385 390 395 400

Met Ser Met Asp Arg Met Arg Arg Glu His Gly Val Thr Gly Tyr Asp
405 410 415

Ser Ala Ile Asp Arg Gly Arg Glu Trp Ile Glu Gly Met Gln Ser Asp
420 425 430

Asp Gly Gly Trp Ala Ala Phe Asp Val Asn Asn Leu Glu Tyr Tyr Leu
435 440 445

Asn Asn Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr
450 455 460

Glu Asp Val Thr Ala Arg Cys Val Ser Met Leu Ala Gln Leu Gly Glu
465 470 475 480

Thr Ala Lys Thr Ser Lys His Val Ala Asp Gly Val Ala Tyr Leu Arg
485 490 495

Lys Thr Gln His Pro Glu Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn
500 505 510

Phe Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala Leu Asn Met Ala Gly
515 520 525

Val Arg His Asp Asp Pro Met Ile Arg Lys Ala Ala Asp Trp Leu Ala
530 535 540

Ser Ile Gln Asn Lys Asp Gly Gly Trp Gly Glu Asp Thr Val Ser Tyr
545 550 555 560

Arg Leu Asp Tyr Lys Gly Trp Glu Ala Ala Pro Ser Thr Ala Ser Gln
565 570 575

Thr Ala Trp Ala Leu Leu Ala Leu Met Ala Ala Gly Glu Val Asp His
580 585 590

Pro Ala Val Ala Arg Gly Val Glu Tyr Leu Ile Ala Thr Gln Asn Glu
595 600 605

Lys Gly Leu Trp Asp Glu Gln Arg Tyr Thr Ala Thr Gly Phe Pro Arg
610 615 620

Val Phe Tyr Leu Arg Tyr His Gly Tyr Ser Lys Phe Phe Pro Leu Trp
625 630 635 640

Gly Leu Ala Arg Tyr Arg Asn Leu Arg Asn Thr Asn Ser Arg Val Val
645 650 655

Gly Val Gly Met
660


<210> 77
<211> 656
<212> PRT
<213> Acetobacter pasteurianus

<400> 77
Met Ala Ala Asp Gly Ser Ala Leu Ser Glu Ser Arg Leu Ser Ser Glu
1 5 10 15

Ala Leu Asp Arg Ala Val Leu Ser Ala His Thr Ala Leu Ser Gln Ala
20 25 30

Gln Gln Asp Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ala Thr
35 40 45

Ile Pro Ala Glu Tyr Ile Leu Leu Glu His Phe Met Asp Arg Ile Asp
50 55 60

Asp Ala Leu Glu Gln Lys Ile Ala Ile Tyr Leu Arg Arg Ile Gln Ser
65 70 75 80

Glu Glu His Gly Gly Trp Pro Leu Tyr His Asn Gly Lys Phe Asp Leu
85 90 95

Ser Ala Thr Val Lys Ala Tyr Phe Ala Leu Lys Ala Val Gly Asp Asp
100 105 110

Ile Asn Ala Pro His Met Gln Arg Ala Arg Glu Ala Ile Leu Asp His
115 120 125

Gly Gly Ala Glu Arg Ser Asn Val Phe Thr Arg Ser Gln Leu Ala Leu
130 135 140

Phe Gly Glu Val Pro Trp Arg Ala Thr Pro Val Met Pro Val Glu Leu
145 150 155 160

Met Leu Leu Pro Ala Lys Ala Phe Phe Ser Val Trp Asn Met Ser Tyr
165 170 175

Trp Ser Arg Thr Val Ile Ala Pro Leu Leu Val Leu Ala Ala Leu Arg
180 185 190

Pro Val Ala Ala Asn Pro Arg Gln Val His Val Arg Glu Leu Phe Val
195 200 205

Thr Pro Pro Glu Lys Val Gln Asp Trp Ile Arg Gly Pro Tyr Arg Ser
210 215 220

Ala Trp Gly Tyr Val Phe Lys Gly Leu Asp Ser Val Leu Arg Pro Val
225 230 235 240

Val Pro Phe Ile Pro Glu Lys Thr His Lys Lys Ala Ile Gln Ala Ala
245 250 255

Leu Asp Phe Ile Glu Pro Arg Leu Asn Gly Lys Asp Gly Leu Gly Ala
260 265 270

Ile Tyr Pro Ala Met Ala Asn Val Val Met Met Tyr Arg Ala Met Gly
275 280 285

Val Pro Asp Glu Asp Pro Arg Ala Lys Thr Ala Trp Glu Ala Val Gln
290 295 300

Ala Leu Ile Val Glu Lys Asp Asp Glu Ala Tyr Cys Gln Pro Cys Val
305 310 315 320

Ser Pro Ile Trp Asp Thr Gly Leu Ser Gly His Ala Met Ile Glu Ala
325 330 335

Ala Ser Gly Pro Asn Gly Ile Ala Pro Glu Lys Thr Val Ala Glu Leu
340 345 350

Lys Lys Ala Ser Ala Trp Leu Arg Ser Lys Gln Ile Leu Asn Val Lys
355 360 365

Gly Asp Trp Ala Val Arg Asn Pro Asn Leu Ala Pro Gly Gly Trp Ala
370 375 380

Phe Gln Tyr Gly Asn Asp Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val
385 390 395 400

Val Gly Met Leu Leu His Arg Glu Gly Asp Pro Thr Asn Ala Glu Ala
405 410 415

Ile Glu Arg Ala Arg Thr Trp Ile Val Gly Met Gln Ser Thr Asp Gly
420 425 430

Gly Trp Gly Ala Phe Asp Ile Asp Asn Asn Lys Asp Val Leu Asn His
435 440 445

Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp
450 455 460

Val Thr Ala Arg Cys Ile Ser Phe Leu Ala Gln Leu Arg Asn Pro Glu
465 470 475 480

Asp Glu Pro Val Ile Gln Arg Gly Leu Glu Tyr Leu Arg Lys Glu Gln
485 490 495

Glu Lys Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr
500 505 510

Gly Thr Trp Ser Ala Leu Cys Ala Leu Asn Ala Ala Gly Val Ser His
515 520 525

Asp Asp Pro Ala Val Val Lys Ala Val Glu Trp Leu Arg Ser Val Gln
530 535 540

Arg Ala Asp Gly Gly Trp Gly Glu Gly Cys Glu Ser Tyr Glu Gly Gly
545 550 555 560

Pro His Gly Thr Tyr Gly Glu Ser Leu Pro Ser Gln Thr Ala Trp Ala
565 570 575

Val Leu Gly Leu Met Ala Ala Gly Arg Arg Asp Asp Pro Ala Val Thr
580 585 590

Arg Gly Ile Ala Trp Leu Ala Asp Gln Gln Asp Ala Asn Gly Glu Trp
595 600 605

His Glu Asp Pro Tyr Asn Ala Val Gly Phe Pro Lys Val Phe Tyr Leu
610 615 620

Arg Tyr His Gly Tyr Lys Gln Phe Phe Pro Leu Met Ala Leu Ala Arg
625 630 635 640

Tyr Arg Asn Leu Glu Ser Ser Asn Thr Arg Arg Val Ser Phe Gly Phe
645 650 655




<210> 78
<211> 684
<212> PRT
<213> Bradyrhizobium sp.

<400> 78
Met Thr Leu Thr Ser Ser Ala Ser Ala Arg Ala Pro Arg Asp Pro Gly
1 5 10 15

Asn Tyr Gln Thr Ala Leu Gln Ser Thr Val Arg Ala Ala Ala Asp Trp
20 25 30

Leu Ile Ala Asn Gln Lys Pro Asp Gly His Trp Val Gly Arg Ala Glu
35 40 45

Ser Asn Ala Cys Met Glu Ala Gln Trp Cys Leu Ala Leu Trp Phe Met
50 55 60

Gly Leu Glu Asp His Pro Leu Arg Lys Arg Leu Gly Gln Ser Leu Leu
65 70 75 80

Asp Thr Gln Arg Pro Asp Gly Ala Trp Gln Val Tyr Phe Asn Ala Pro
85 90 95

Asn Gly Asp Ile Asn Ala Thr Val Glu Ala Tyr Ala Ala Leu Arg Ser
100 105 110

Leu Gly Tyr Pro Asp Ser Glu Pro Ala Val Arg Arg Ala Arg Glu Trp
115 120 125

Ile Glu Ala Lys Gly Gly Leu Arg Asn Ile Arg Val Phe Thr Arg Tyr
130 135 140

Trp Leu Ala Leu Ile Gly Glu Trp Pro Trp Glu Lys Thr Pro Asn Ile
145 150 155 160

Pro Pro Glu Val Ile Trp Phe Pro Leu Trp Phe Pro Phe Ser Ile Tyr
165 170 175

Asn Phe Ala Gln Trp Ala Arg Ala Thr Leu Met Pro Ile Ala Leu Leu
180 185 190

Ser Ala Arg Arg Pro Ser Arg Pro Leu Pro Pro Glu Asn Arg Leu Asp
195 200 205

Thr Leu Phe Pro Arg Gly Arg Asp Ala Phe Asp Tyr Glu Leu Pro Val
210 215 220

Lys Ala Asn Ala Gly Gly Trp Asp Lys Phe Phe Arg Gly Ala Asp Lys
225 230 235 240

Val Leu His Ala Leu Gln Asn Phe Gly Asn Arg Leu Asn Leu Gly Leu
245 250 255

Phe Arg Pro Ala Ala Thr Ser Arg Val Leu Glu Trp Met Ile Arg His
260 265 270

Gln Asp Phe Asp Gly Ala Trp Gly Gly Ile Gln Pro Pro Trp Ile Tyr
275 280 285

Gly Leu Met Ala Leu Tyr Ala Glu Gly Tyr Pro Leu Asn His Pro Val
290 295 300

Leu Ala Lys Gly Leu Asp Ala Leu Asn Asp Pro Gly Trp Arg Val Asp
305 310 315 320

Val Gly Glu Ala Thr Tyr Ile Gln Ala Thr Asn Ser Pro Val Trp Asp
325 330 335

Thr Ile Leu Thr Leu Leu Ala Phe Asp Asp Ala Gly Val Leu Gly Asp
340 345 350

Tyr Pro Asp Ala Val Asp Lys Ala Val Asn Trp Val Leu Ala Arg Gln
355 360 365

Val Arg Val Pro Gly Asp Trp Ser Met Lys Leu Pro His Val Lys Pro
370 375 380

Gly Gly Trp Ala Phe Glu Tyr Ala Asn Asn His Tyr Pro Asp Thr Asp
385 390 395 400

Asp Thr Ala Val Ala Leu Ile Ala Leu Ala Pro Leu Arg His Asp Pro
405 410 415

Lys Trp Lys Ala Lys Gly Ile Asp Glu Ala Ile Gln Leu Gly Val Asp
420 425 430

Trp Leu Ile Gly Met Gln Ser Gln Gly Gly Gly Trp Gly Ala Phe Asp
435 440 445

Lys Asp Asn Asn Gln Gln Ile Leu Thr Lys Ile Pro Phe Cys Asp Tyr
450 455 460

Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val Thr Ala His Ile Val
465 470 475 480

Glu Ala Phe Gly Lys Leu Gly Ile Ser Arg Asn His Pro Ser Met Val
485 490 495

Gln Ala Leu Asp Tyr Ile Arg Lys Glu Gln Glu Pro Ser Gly Pro Trp
500 505 510

Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ala Val Leu
515 520 525

Pro Ala Leu Ala Ala Ile Gly Glu Asp Met Thr Gln Pro Tyr Ile Gly
530 535 540

Arg Ala Cys Asp Trp Leu Val Ala His Gln Gln Pro Asp Gly Gly Trp
545 550 555 560

Gly Glu Ser Cys Ala Ser Tyr Met Asp Ile Ser Ala Val Gly Arg Gly
565 570 575

Thr Thr Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Ala Leu Leu Ala
580 585 590

Ala Asn Arg Pro Gln Asp Lys Asp Ala Ile Glu Arg Gly Cys Met Trp
595 600 605

Leu Val Glu Arg Gln Ser Ala Gly Thr Trp Asp Glu Pro Glu Phe Thr
610 615 620

Gly Thr Gly Phe Pro Gly Tyr Gly Val Gly Gln Thr Ile Lys Leu Thr
625 630 635 640

Asp Pro Ser Leu Gln Glu Arg Leu Met Gln Gly Pro Glu Leu Ser Arg
645 650 655

Ala Phe Met Leu Arg Tyr Gly Met Tyr Arg His Tyr Phe Pro Leu Met
660 665 670

Ala Leu Gly Arg Ala Leu Arg Pro Gln Gly His Gly
675 680


<210> 79
<211> 660
<212> PRT
<213> Brevibacillus brevis

<400> 79
Met Arg Ile Gly Thr Thr Thr Asn Pro Ser Met Pro Phe Pro Leu Ser
1 5 10 15

Ser Ser Gly Ala Val Phe Tyr Arg Glu Val Asn Glu Leu Arg Glu Val
20 25 30

Gln Gln Glu Ile Asn Arg Ile Gln Ala Phe Leu Leu Gln Arg Gln Gln
35 40 45

Glu Asp Gly Thr Trp Arg Phe Cys Leu Glu Ser Ser Pro Met Thr Asp
50 55 60

Ser His Met Ile Ile Leu Leu Arg Thr Leu Gly Ile His Asp Glu Arg
65 70 75 80

Leu Met Glu Lys Leu Thr Ala His Ile Thr Ala Leu Gln His Asp Asn
85 90 95

Gly Ala Trp Lys Leu Tyr Pro Asp Glu Gln Glu Gly His Leu Ser Thr
100 105 110

Thr Ile Asp Ser Tyr Tyr Ala Leu Leu Leu Ser Gly Lys Tyr Thr Lys
115 120 125

Asn Glu Pro Arg Met Ala Leu Ala Arg Ser Phe Ile Leu Glu Lys Gly
130 135 140

Gly Leu Thr Gln Ala Asn Met Leu Thr Lys Phe Ala Thr Ala Leu Thr
145 150 155 160

Gly Gln Tyr Gln Trp Pro Ser His Phe Leu Val Pro Val Glu Ile Ala
165 170 175

Leu Leu Pro Pro Ser Phe Pro Val Ser Phe Tyr Asp Phe Val Gly Tyr
180 185 190

Ala Arg Val His Leu Ala Pro Met Met Ile Val Ala Asp Arg Asn Tyr
195 200 205

Val Lys Lys Pro Asp Asn Ala Pro Asp Leu Ser Asp Leu Tyr Ala Asp
210 215 220

Thr Pro Ile Ser Arg Gly Leu Tyr Pro His Arg Phe Leu Glu Asn Phe
225 230 235 240

Leu Lys Glu Gly Gln Ser Phe Leu Ala Thr Ile His Asp Ser Leu Gln
245 250 255

Gln Leu Pro Phe Leu Pro Gly Gln Leu His Lys Leu Ala Leu Arg Arg
260 265 270

Leu Glu Gln Tyr Ile Leu Ala Arg Ile Glu Pro Asp Gly Thr Leu Tyr
275 280 285

Asn Tyr Ser Thr Ser Thr Phe Phe Met Ile Phe Ala Leu Leu Ala Arg
290 295 300

Gly Phe Ser Pro Lys Asp Pro Leu Ile Gln Lys Ala Met Gln Gly Leu
305 310 315 320

Thr Gly Ser Val Tyr Asp Tyr Glu Asn Gly Ala His Leu Gln Leu Ala
325 330 335

Thr Ser Ala Val Trp Asp Thr Ala Leu Leu Thr Phe Ser Leu Gln Lys
340 345 350

Ser Gly Leu Ser Pro Thr His Pro Ala Ile Gln Lys Ala Asn Arg Tyr
355 360 365

Leu Leu Arg Lys Gln Gln His Thr Tyr Gly Asp Trp Lys Ile Arg Asn
370 375 380

Pro Asn Gly Lys Pro Gly Gly Trp Gly Phe Ser Asp Tyr Asn Thr Met
385 390 395 400

Asn Pro Asp Ile Asp Asp Thr Thr Ala Ala Leu Arg Ser Leu Arg Leu
405 410 415

Leu Ala Arg Thr Asp Val Thr Ala Ala Thr Ala Trp Lys Arg Gly Leu
420 425 430

Glu Trp Leu Leu Ser Met Gln Asn Asp Asp Gly Gly Trp Pro Ala Phe
435 440 445

Glu Arg Asn Thr Asp Ala Asp Phe Ile Arg His Leu Pro Ile Glu Gly
450 455 460

Ala Asp Thr Val Ser Thr Asp Pro Ser Ser Ala Asp Leu Thr Gly Arg
465 470 475 480

Thr Leu Glu Phe Leu Gly Asn Tyr Ala Gly Arg Thr Leu Thr Asp Leu
485 490 495

His Val Glu Lys Gly Val Arg Trp Leu Leu Lys His Gln Glu Ser Asp
500 505 510

Gly Ser Trp Tyr Gly Arg Trp Gly Ile Ala Tyr Leu Tyr Gly Thr Trp
515 520 525

Ala Ala Ile Thr Gly Leu Met Ala Val Gly Phe Ser Pro Thr Glu Pro
530 535 540

Ala Ile Gln Lys Ala Val Ala Trp Leu Val Ala Asn Gln Asn Pro Asp
545 550 555 560

Gly Gly Trp Gly Glu Ser Cys Gln Ser Asp Leu Lys Lys Thr Tyr Val
565 570 575

Pro Leu Gly Ala Ser Thr Pro Ser Gln Thr Ala Trp Ala Ile Asp Ala
580 585 590

Leu Ile Ala Val Ser Ser Lys Pro Thr Ala Glu Leu Gln Arg Gly Ile
595 600 605

Arg Tyr Leu Leu Thr His Asn Gln Ala Asn Asp Trp Thr Thr Arg Tyr
610 615 620

Pro Thr Gly Gly Gly Arg Pro Gly Gly Thr Tyr Phe Ala Tyr His Ser
625 630 635 640

Tyr Arg Trp Ile Trp Pro Leu Leu Ala Leu Ser His Tyr Gln Val Lys
645 650 655

Tyr Ala Asn Thr
660


<210> 80
<211> 682
<212> PRT
<213> Burkholderia ambifaria

<400> 80
Met Ile Arg Arg Met Asn Lys Pro Ala Pro Ser Pro Trp Ser Ala Leu
1 5 10 15

Asp Thr Ala Ile Ala Arg Gly Arg Asp Ala Leu Met Arg Leu Gln Gln
20 25 30

Pro Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Asp Lys Ile Asp Asp Ala
50 55 60

Arg Gln Glu Lys Met Ala Arg Tyr Leu Arg Ala Ile Gln Arg Leu Asp
65 70 75 80

Thr His Gly Gly Trp Asp Leu Tyr Leu Asp Gly Asp Pro Asp Leu Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

His Ala Pro His Met Val Arg Ala Arg Asp Ala Ile Leu Lys Leu Gly
115 120 125

Gly Ala Ala Arg Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Thr Pro Phe Met Pro Ile Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Ala Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

Arg Ala Arg Asn Pro Arg Asn Ile Ala Ile Pro Glu Leu Phe Val Thr
195 200 205

Pro Pro Asp Gln Glu Arg Gln Tyr Phe Pro Pro Ala Arg Gly Met Arg
210 215 220

Arg Ala Phe Leu Ala Leu Asp Arg Val Val Arg His Val Glu Pro Leu
225 230 235 240

Leu Pro Lys Arg Leu Arg Gln Arg Ala Ile Arg His Ala Gln Ala Trp
245 250 255

Cys Ala Glu Arg Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Ser Tyr Gln Met Met Asp Val Leu Gly Tyr Pro Asp
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Glu Lys Leu Leu
290 295 300

Val Thr Arg Pro Asp Gly Ser Met Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Gly
325 330 335

Val Ala Val Pro Glu Ala Gly Ala Pro Ala Gly Ala Leu Asp Glu Leu
340 345 350

Asp Ala Arg Ile Ala Arg Ala Tyr Asp Trp Leu Ala Glu Arg Gln Val
355 360 365

Asn Asp Leu Arg Gly Asp Trp Ile Glu Asn Ala Pro Ala Asp Thr Gln
370 375 380

Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp Ile
385 390 395 400

Asp Asp Ser Ala Val Ile Thr Ala Met Leu Asp Arg Arg Gly Arg Thr
405 410 415

His Arg Asn Ala Asp Gly Ser His Pro Tyr Ala Ala Arg Val Ala Arg
420 425 430

Ala Leu Asp Trp Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe Ala
435 440 445

Ala Phe Asp Ala Asp Cys Asp Arg Met Tyr Leu Asn Ala Ile Pro Phe
450 455 460

Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly
465 470 475 480

Arg Val Leu Leu Cys Phe Gly Val Thr Lys Arg Ala Asp Asp Arg Ala
485 490 495

Ser Leu Ala Arg Ala Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro Asp
500 505 510

Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr Trp
515 520 525

Ser Val Leu Ala Gly Leu Ala Leu Ala Gly Glu Asp Pro Ser Gln Pro
530 535 540

Tyr Ile Ala Arg Ala Leu Ala Trp Leu Arg Ala Arg Gln His Ala Asp
545 550 555 560

Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Ile Asp Pro Ala Leu Ala
565 570 575

Gly Thr Asn Ala Gly Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala Leu
580 585 590

Leu Ala Gln Met Ala Phe Gly Asp Gly Glu Ser Glu Ser Val Lys Arg
595 600 605

Gly Ile Ala Tyr Leu Gln Ser Val Gln Gln Asp Asp Gly Phe Trp Trp
610 615 620

His Arg Ser His Asn Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu Lys
625 630 635 640

Tyr His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr
645 650 655

Arg Arg Leu Ala Gly Gly Ala Ser Ser Ala Gly Ala His Thr Val Pro
660 665 670

Ala Ser Thr Gly Ala Asp Ala Ala Leu Ala
675 680


<210> 81
<211> 682
<212> PRT
<213> Burkholderia ambifaria

<400> 81
Met Ile Arg Arg Met Asn Lys Pro Ala Pro Ser Pro Trp Ser Ala Leu
1 5 10 15

Asp Ala Ala Ile Ala Arg Gly Arg Asp Ala Leu Met Arg Leu Gln Gln
20 25 30

Pro Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Asp Lys Ile Asp Asp Ala
50 55 60

Arg Gln Glu Lys Met Ala Arg Tyr Leu Arg Ala Ile Gln Arg Leu Asp
65 70 75 80

Thr His Gly Gly Trp Asp Leu Tyr Val Asp Gly Asp Pro Asp Val Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

His Ala Pro His Met Val Arg Ala Arg Asp Ala Ile Leu Ala Leu Gly
115 120 125

Gly Ala Ala Arg Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Ala Pro Phe Met Pro Ile Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Thr Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

His Ala Arg Asn Pro Arg Asn Ile Ala Ile Pro Glu Leu Phe Val Thr
195 200 205

Pro Pro Asp Gln Glu Arg His Tyr Phe Pro Pro Ala Arg Gly Met Arg
210 215 220

Arg Ala Phe Leu Ala Leu Asp Arg Val Val Arg His Ala Glu Pro Leu
225 230 235 240

Leu Pro Lys Arg Leu Arg Gln Arg Ala Ile Arg His Ala Gln Ala Trp
245 250 255

Cys Ala Glu Arg Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Ser Tyr Gln Met Met Asp Val Leu Gly Tyr Pro Ala
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Glu Lys Leu Leu
290 295 300

Val Thr Arg Pro Asp Gly Ser Met Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Gly
325 330 335

Val Ala Val His Glu Ala Gly Ala Pro Ala Ser Ala Leu Asp Glu Leu
340 345 350

Asp Ala Arg Ile Ala Arg Ala Tyr Asp Trp Leu Ala Glu Arg Gln Val
355 360 365

Asn Asp Leu Arg Gly Asp Trp Ile Glu Asn Ala Pro Ala Asp Thr Gln
370 375 380

Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp Ile
385 390 395 400

Asp Asp Ser Ala Val Val Thr Ala Met Leu Asp Arg Arg Gly Arg Thr
405 410 415

His Arg Asn Ala Asp Gly Thr His Pro Tyr Ala Ala Arg Val Ala Arg
420 425 430

Ala Leu Asp Trp Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe Ala
435 440 445

Ala Phe Asp Ala Asp Cys Asp Arg Met Tyr Leu Asn Ala Ile Pro Phe
450 455 460

Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly
465 470 475 480

Arg Val Leu Leu Cys Phe Gly Val Thr Lys Arg Ala Asp Asp Arg Ala
485 490 495

Ser Leu Ala Arg Ala Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro Asp
500 505 510

Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr Trp
515 520 525

Ser Val Leu Ala Gly Leu Ala Leu Ala Gly Glu Asp Pro Ser Gln Pro
530 535 540

Tyr Ile Ala Arg Ala Leu Ala Trp Leu Arg Ala Arg Gln His Ala Asp
545 550 555 560

Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Ile Asp Pro Ala Leu Ala
565 570 575

Gly Thr Asn Ala Gly Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala Leu
580 585 590

Leu Ala Gln Met Ala Phe Gly Asp Gly Glu Ser Glu Ser Val Lys Arg
595 600 605

Gly Ile Ala Tyr Leu Gln Ser Val Gln Gln Asp Asp Gly Phe Trp Trp
610 615 620

His Arg Ser His Asn Ala Pro Gly Phe Thr Arg Ile Phe Tyr Leu Lys
625 630 635 640

Tyr His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr
645 650 655

Arg Arg Leu Ala Gly Gly Ala Ser Ser Ala Gly Ala His Ala Val Pro
660 665 670

Ala Ser Thr Ala Ala Asp Ala Ala Leu Ala
675 680


<210> 82
<211> 678
<212> PRT
<213> Burkholderia ambifaria

<400> 82
Met Asn Lys Pro Ala Pro Ser Pro Trp Ser Ala Leu Asp Thr Ala Ile
1 5 10 15

Ala Arg Gly Arg Asp Ala Leu Met Arg Leu Gln Gln Pro Asp Gly Ser
20 25 30

Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr Ala Glu Tyr Ile
35 40 45

Leu Met Met His Phe Met Asp Lys Ile Asp Asp Val Arg Gln Glu Lys
50 55 60

Met Ala Arg Tyr Leu Arg Ala Ile Gln Arg Leu Asp Thr His Gly Gly
65 70 75 80

Trp Asp Leu Tyr Val Asp Gly Asp Pro Asp Val Ser Cys Ser Val Lys
85 90 95

Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu His Ala Pro His
100 105 110

Met Val Arg Ala Arg Asp Ala Ile Leu Ala Leu Gly Gly Ala Ala Arg
115 120 125

Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe Gly Gln Val Pro
130 135 140

Trp Arg Ala Thr Pro Phe Met Pro Ile Glu Phe Val Leu Phe Pro Lys
145 150 155 160

Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp Ala Arg Thr Thr
165 170 175

Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala Arg Ala Arg Asn
180 185 190

Pro Arg Asn Ile Ala Ile Pro Glu Leu Phe Val Thr Pro Pro Asp Glu
195 200 205

Glu Arg His Tyr Phe Pro Pro Ala Arg Gly Met Arg Arg Ala Phe Leu
210 215 220

Ala Leu Asp Arg Val Val Arg His Val Glu Pro Leu Leu Pro Lys Arg
225 230 235 240

Leu Arg Gln Arg Ala Ile Arg His Ala Gln Ala Trp Cys Ala Glu Arg
245 250 255

Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro Pro Ile Val Tyr
260 265 270

Ser Tyr Gln Met Met Asp Val Leu Gly Tyr Pro Asp Asp His Pro Arg
275 280 285

Arg Arg Asp Cys Glu Asn Ala Leu Glu Lys Leu Leu Val Thr Arg Thr
290 295 300

Asp Gly Ser Met Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr
305 310 315 320

Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Ala Val Ala Val Pro
325 330 335

Glu Ala Gly Ala Arg Ala Ser Ala Leu Asp Glu Leu Asp Ala Arg Ile
340 345 350

Ala Arg Ala Tyr Asp Trp Leu Ala Glu Arg Gln Val Asn Asp Leu Arg
355 360 365

Gly Asp Trp Ile Glu Asn Ala Pro Ala Asp Thr Gln Pro Gly Gly Trp
370 375 380

Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp Ile Asp Asp Thr Ala
385 390 395 400

Val Val Thr Ala Met Leu Asp Arg Arg Gly Arg Thr His Arg Asn Ala
405 410 415

Asp Gly Ser His Pro Tyr Ala Ala Arg Val Ala Arg Ala Leu Asp Trp
420 425 430

Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe Ala Ala Phe Asp Ala
435 440 445

Asp Cys Asp Arg Met Tyr Leu Asn Ala Ile Pro Phe Ala Asp His Gly
450 455 460

Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly Arg Val Leu Leu
465 470 475 480

Cys Phe Gly Val Thr Lys Arg Ala Ala Asp Arg Ala Ser Leu Ala Arg
485 490 495

Ala Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro Asp Gly Ser Trp Trp
500 505 510

Gly Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr Trp Ser Val Leu Ala
515 520 525

Gly Leu Ala Leu Ala Gly Glu Asp Pro Ser Gln Pro Tyr Ile Ala Arg
530 535 540

Ala Leu Ala Trp Leu Arg Ala Arg Gln His Ala Asp Gly Gly Trp Gly
545 550 555 560

Glu Thr Asn Asp Ser Tyr Ile Asp Pro Thr Leu Ala Gly Thr Asn Ala
565 570 575

Gly Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala Leu Leu Ala Gln Met
580 585 590

Ala Phe Gly Asp Cys Glu Ser Glu Ser Val Arg Arg Gly Ile Ala Tyr
595 600 605

Leu Gln Ser Val Gln Gln Asp Asp Gly Phe Trp Trp His Arg Ser His
610 615 620

Asn Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu Lys Tyr His Gly Tyr
625 630 635 640

Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Arg Leu Ala
645 650 655

Ser Gly Val Ser Ser Ala Gly Val His Ala Val Pro Ala Ser Thr Gly
660 665 670

Ala Asp Ala Ala Leu Ala
675


<210> 83
<211> 657
<212> PRT
<213> Burkholderia ambifaria

<400> 83
Met Asn Asp Leu Thr Glu Met Ala Thr Leu Ser Ala Gly Thr Val Pro
1 5 10 15

Ala Gly Leu Asp Ala Ala Val Ala Ser Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Asn Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu Thr
50 55 60

Pro Asn Leu Glu Leu Glu Gln Lys Ile Gly Arg Tyr Leu Arg Arg Val
65 70 75 80

Gln Gln Ala Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Tyr Gly Ala Ile Pro Trp Arg Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Ile Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe
195 200 205

Val Asp Pro Pro Val Asn Ala Gly Leu Leu Pro Arg Gln Gly His Gln
210 215 220

Ser Pro Gly Trp Phe Ala Phe Phe Arg Val Val Asp His Val Leu Arg
225 230 235 240

Ala Ala Asp Gly Leu Phe Pro Ser Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ser Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Asp Val
275 280 285

Leu Gly Tyr Ala Glu Asp His Pro Asn Arg Ala Ile Ala Arg Lys Ser
290 295 300

Ile Glu Lys Leu Leu Val Val His Glu Asp Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu
325 330 335

Glu Thr Gly Asp Ala Arg Ala Glu Glu Ala Val Ile Arg Gly Leu Glu
340 345 350

Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro His Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Val Ala Met
385 390 395 400

Asp Arg Val Gln Lys Leu Lys His Asn Asp Thr Phe Arg Asp Ser Ile
405 410 415

Ala Leu Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ala Gln Leu Gly Glu Thr Pro Leu
465 470 475 480

Asn Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Val Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ala Leu Asn Ala Ala Gly Leu Thr Pro
515 520 525

Asp Asp Pro Arg Val Lys Arg Gly Ala Gln Trp Leu Leu Ser Ile Gln
530 535 540

Asn Lys Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asn
545 550 555 560

Tyr Arg Gly Phe Glu Gln Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asn Asn Pro Ala Val
580 585 590

Ala Arg Gly Val Glu Tyr Leu Ile Ala Glu Gln Lys Glu His Gly Leu
595 600 605

Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Asp Asn Ala Thr His Val Thr Phe Gly
645 650 655

Leu


<210> 84
<211> 687
<212> PRT
<213> Burkholderia cenocepacia

<400> 84
Met Ile Arg Arg Met Asn Gln Ser Ala Pro Ser Ser Trp Ser Ala Leu
1 5 10 15

Asp Ala Ala Ile Ala Arg Gly Arg Asp Ala Leu Val Arg Leu Gln Gln
20 25 30

Pro Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Asp Arg Ile Asp Asp Val
50 55 60

Arg Gln Glu Lys Met Ala Arg Tyr Leu Arg Ala Asn Gln Arg Leu Asp
65 70 75 80

Thr His Gly Ala Trp Asp Leu Tyr Val Asp Gly Ala Pro Asp Val Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

His Ala Pro His Met Ile Arg Ala Arg Asp Ala Ile Leu Lys Leu Gly
115 120 125

Gly Ala Ala Arg Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Ala Pro Phe Met Ala Val Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Ala Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

Arg Ala Arg Asn Pro Arg Asn Val Ser Ile Arg Glu Leu Phe Val Thr
195 200 205

Pro Pro Glu Gln Glu Arg His Tyr Phe Pro Pro Ala Arg Gly Met Arg
210 215 220

Arg Leu Phe Leu Ala Leu Asp Arg Thr Val Arg Pro Ile Glu Pro Leu
225 230 235 240

Leu Pro Lys Arg Leu Arg Gln Arg Ala Ile Arg His Ala Glu Ala Trp
245 250 255

Cys Ala Glu Arg Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Ser Tyr Gln Met Met Gln Val Leu Gly Tyr Pro Asp
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Glu Lys Leu Leu
290 295 300

Val Thr Arg Pro Asp Gly Ser Met Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Gly
325 330 335

Val Ala Ala Pro Glu Thr Gly Asp Thr Ala Thr Gly Ala Pro Arg Asp
340 345 350

Leu Asp Gly Arg Ile Ala Arg Ala Tyr Asp Trp Leu Ala Thr Arg Gln
355 360 365

Val Asn Asp Leu Arg Gly Asp Trp Ile Glu Asn Ala Pro Ala Asp Val
370 375 380

Glu Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp
385 390 395 400

Ile Asp Asp Thr Ala Leu Val Thr Ala Met Leu Asp Arg Arg Gly Arg
405 410 415

Thr His Arg Ala Ala Asp Gly Thr His Pro Tyr Ala Ser Cys Val Ser
420 425 430

Arg Ala Leu Asp Trp Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe
435 440 445

Ala Ala Phe Asp Ala Asp Cys Asp Arg Met Tyr Leu Asn Ala Ile Pro
450 455 460

Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser
465 470 475 480

Gly Arg Val Leu Leu Cys Phe Gly Val Thr Lys Arg Ala Ala Asp Arg
485 490 495

Ala Ser Leu Ala Arg Ala Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro
500 505 510

Asp Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr
515 520 525

Trp Ser Val Leu Ala Gly Leu Ala Leu Ala Gly Glu Asp Lys Ser Gln
530 535 540

Pro Tyr Ile Ala Arg Ala Leu Asp Trp Leu Arg Ala Arg Gln His Ala
545 550 555 560

Asp Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Leu Asp Pro Lys Leu
565 570 575

Ala Gly Thr Asn Gly Gly Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala
580 585 590

Leu Leu Ala Gln Met Ala Phe Gly Asp Cys Glu Ser Asp Ser Val Lys
595 600 605

Arg Gly Ile Ala Tyr Leu Gln Ser Val Gln Gln Glu Asp Gly Phe Trp
610 615 620

Trp His Arg Ser His Asn Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu
625 630 635 640

Lys Tyr His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg
645 650 655

Tyr Arg Arg Leu Ala Gly Ala Lys Asp Ala Gly Ala Thr Arg Ser Gly
660 665 670

Ala Ser Gly Ala Ser Ala Thr Ser Val Thr Asp Asp Ala Leu Ala
675 680 685


<210> 85
<211> 684
<212> PRT
<213> Burkholderia cenocepacia

<400> 85
Met Ile Arg Arg Met Asn Lys Ser Ala Pro Ser Pro Trp Ser Ala Leu
1 5 10 15

Asp Ala Ala Ile Ala Arg Gly Arg Asp Ala Leu Val Arg Leu Gln Gln
20 25 30

Pro Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Asp Arg Ile Asp Asp Val
50 55 60

Arg Gln Glu Arg Met Ala Arg Tyr Leu Arg Ala Asn Gln Arg Leu Asp
65 70 75 80

Thr His Gly Ala Trp Asp Leu Tyr Val Asp Gly Ala Pro Asp Val Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

His Ala Pro His Met Ile Arg Ala Arg Asp Ala Ile Leu Lys Leu Gly
115 120 125

Gly Ala Ala Arg Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Ala Pro Phe Met Pro Ile Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Ala Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

Arg Ala Arg Asn Pro Arg Asn Val Ser Ile Arg Glu Leu Phe Val Thr
195 200 205

Pro Pro Glu Gln Glu Arg His Tyr Phe Leu Pro Ala Arg Gly Met Arg
210 215 220

Arg Leu Phe Leu Ala Leu Asp Arg Thr Val Arg Pro Ile Glu Pro Leu
225 230 235 240

Leu Pro Lys Arg Leu Arg Gln Arg Ala Ile Arg His Ala Glu Ala Trp
245 250 255

Cys Ala Glu Arg Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Ser Tyr Gln Met Met Gln Val Leu Gly Tyr Pro Asp
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Glu Lys Leu Leu
290 295 300

Val Thr Arg Pro Asp Gly Ser Met Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Gly
325 330 335

Val Ala Ala Pro Glu Thr Gly Asp Thr Ala Ser Gly Ala Leu Arg Glu
340 345 350

Leu Asp Glu Arg Ile Ala Arg Ala Tyr Asp Trp Leu Ala Thr Arg Gln
355 360 365

Val Asn Asp Leu Arg Gly Asp Trp Ile Glu Asn Ala Pro Ala Asp Val
370 375 380

Glu Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp
385 390 395 400

Ile Asp Asp Thr Ala Leu Val Thr Ala Met Leu Asp Arg Arg Gly Arg
405 410 415

Thr His Arg Gly Ala Asp Gly Thr His Pro Tyr Ala Ser Arg Val Ala
420 425 430

Arg Ala Leu Asp Trp Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe
435 440 445

Ala Ala Phe Asp Ala Asp Cys Asp Arg Met Tyr Leu Asn Ala Ile Pro
450 455 460

Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser
465 470 475 480

Gly Arg Val Leu Leu Cys Phe Gly Val Thr Lys Arg Ala Ala Asp Arg
485 490 495

Ala Ser Leu Ala His Ala Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro
500 505 510

Asp Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr
515 520 525

Trp Ser Val Leu Ala Gly Leu Ala Leu Ala Gly Glu Asp Lys Ser Gln
530 535 540

Pro Tyr Ile Thr Arg Ala Leu Asp Trp Leu Arg Ala Arg Gln His Ala
545 550 555 560

Asp Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Ile Asp Pro Lys Leu
565 570 575

Ala Gly Thr Asn Asp Gly Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala
580 585 590

Leu Leu Ala Gln Met Ala Phe Gly Asp Cys Glu Ser Asp Ser Val Lys
595 600 605

Arg Gly Ile Ala Tyr Leu Gln Ser Val Gln Gln Glu Asp Gly Phe Trp
610 615 620

Trp His Arg Ser His Asn Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu
625 630 635 640

Lys Tyr His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg
645 650 655

Tyr Arg Arg Leu Ala Gly Ala Lys Asp Ala Asp Ala Thr Arg Ser Pro
660 665 670

Ala Ser Ala Thr Pro Ala Thr Asp Asn Ala Leu Ala
675 680


<210> 86
<211> 679
<212> PRT
<213> Burkholderia cenocepacia

<400> 86
Met Ile Arg Arg Met Asn Lys Ser Ala Pro Ser Pro Trp Ser Thr Leu
1 5 10 15

Asp Thr Ala Ile Ala Arg Gly Arg Asp Ala Leu Val Arg Leu Gln Gln
20 25 30

Pro Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Asp Arg Ile Asp Asp Val
50 55 60

Arg Gln Glu Lys Met Ala Arg Tyr Leu Arg Ala Asn Gln Arg Leu Asp
65 70 75 80

Thr His Gly Ala Trp Asp Leu Tyr Val Asp Gly Ala Pro Asp Val Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

Gln Ala Pro His Met Ile Arg Ala Arg Asp Ala Ile Leu Lys Leu Gly
115 120 125

Gly Ala Ala Arg Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Ala Pro Phe Met Pro Ile Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Ala Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

Arg Ala Arg Asn Pro Arg Asn Val Ser Ile Arg Glu Leu Phe Val Thr
195 200 205

Pro Pro Glu Gln Glu Arg Arg Tyr Phe Pro Pro Ala Arg Gly Met Arg
210 215 220

Arg Leu Phe Leu Ala Leu Asp Arg Ala Val Arg His Ile Glu Pro Leu
225 230 235 240

Met Pro Lys Arg Leu Arg Gln Arg Ala Ile Arg His Ala Gln Ala Trp
245 250 255

Cys Ala Glu Arg Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Ser Tyr Gln Met Met Gln Val Leu Gly Tyr Pro Asp
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Glu Lys Leu Leu
290 295 300

Val Thr Arg Pro Asp Gly Ser Val Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Gly
325 330 335

Val Ala Ala Pro Glu Thr Gly Glu Thr Ala Ala Gly Thr Leu Arg Glu
340 345 350

Leu Asp Glu Arg Ile Ala Arg Ala Tyr Asp Trp Leu Ala Ala Arg Gln
355 360 365

Val Asn Asp Leu Arg Gly Asp Trp Ile Glu Asn Val Pro Ala Asp Val
370 375 380

Glu Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp
385 390 395 400

Ile Asp Asp Ser Ala Leu Val Thr Ala Met Leu Asp Arg Arg Gly Arg
405 410 415

Thr His Arg His Ala Asp Gly Thr Asn Pro Tyr Ala Pro Arg Val Ala
420 425 430

Arg Ala Leu Asp Trp Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe
435 440 445

Ala Ala Phe Asp Ala Asp Cys Asp Arg Met Tyr Leu Asn Ala Ile Pro
450 455 460

Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser
465 470 475 480

Gly Arg Val Leu Leu Cys Phe Gly Val Thr Lys Arg Ala Glu Asp Arg
485 490 495

Ala Ser Leu Ala Arg Cys Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro
500 505 510

Asp Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr
515 520 525

Trp Ser Val Leu Ala Gly Leu Ala Leu Ala Gly Glu Asp Lys Ser Gln
530 535 540

Pro Tyr Ile Ala Arg Ala Leu Asp Trp Leu Arg Ala Arg Gln His Ala
545 550 555 560

Asp Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Leu Asp Pro Thr Leu
565 570 575

Ala Gly Thr Asn Gly Gly Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala
580 585 590

Leu Leu Ala Gln Met Ala Phe Gly Asp Cys Glu Ser Asp Ser Val Lys
595 600 605

Arg Gly Ile Ala Tyr Leu Gln Ser Val Gln Gln Glu Asp Gly Phe Trp
610 615 620

Trp His Arg Ser His Asn Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu
625 630 635 640

Lys Tyr His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg
645 650 655

Tyr Arg Arg Leu Ala Gly Ala Ala Ala Ala Pro Pro Ala Ala Leu Val
660 665 670

Ala Ala Asp Thr Ala Leu Ala
675


<210> 87
<211> 657
<212> PRT
<213> Burkholderia cenocepacia

<400> 87
Met Asn Asp Leu Thr Glu Met Ala Thr Leu Ser Ala Gly Ala Val Pro
1 5 10 15

Ala Gly Val Asp Ala Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Gln Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu Thr
50 55 60

Pro Asn Leu Glu Leu Glu Gln Lys Ile Gly Lys Tyr Leu Arg Arg Ile
65 70 75 80

Gln Gln Ala Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Tyr Gly Ala Ile Pro Trp Arg Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Leu Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe
195 200 205

Ile Asp Pro Pro Val Asn Ala Gly Leu Leu Pro Arg Gln Gly His Gln
210 215 220

Ser Pro Gly Trp Phe Ala Phe Phe Arg Val Val Asp His Ala Leu Arg
225 230 235 240

Ala Val Asp Gly Leu Phe Pro Ser Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ser Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ser Val Met Met Tyr Ala Ala
275 280 285

Leu Gly Tyr Ala Glu Asp His Pro Asn Arg Ala Ile Ala Arg Lys Ser
290 295 300

Val Glu Lys Leu Leu Val Val His Asp Asp Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu
325 330 335

Glu Thr Gly Asp Ala Arg Ala Gln Glu Ala Val Leu Arg Gly Leu Glu
340 345 350

Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro Asn Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Met Ala Met
385 390 395 400

Asp Arg Ala Gln Lys Leu Thr Gln Ser Asp Thr Tyr Arg Glu Ser Met
405 410 415

Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ser Gln Leu Gly Glu Thr Pro Leu
465 470 475 480

Asn Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Val Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly Leu Thr Pro
515 520 525

Asp Asp Pro Arg Met Lys Arg Gly Ala Gln Trp Leu Leu Ser Ile Gln
530 535 540

Asn Lys Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asn
545 550 555 560

Tyr Arg Gly Tyr Glu Gln Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asn Asn Pro Ala Val
580 585 590

Ala Arg Gly Val Asp Tyr Leu Val Ala Gln Gln Asn Glu Glu Gly Leu
595 600 605

Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Ala Asn Ala Thr Arg Val Thr Val Gly
645 650 655

Met


<210> 88
<211> 658
<212> PRT
<213> Burkholderia dolosa

<400> 88
Met Asn Asp Leu Thr Asp Met Ala Thr Leu Ser Ala Gly Ala Ala Pro
1 5 10 15

Ala Ala Asp Leu Asp Ala Ala Val Ala Arg Ala Thr Asp Ala Leu Leu
20 25 30

Ala Ala Gln Asn Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp
35 40 45

Ser Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu
50 55 60

Thr Pro Asn Leu Glu Leu Glu Arg Lys Ile Gly Arg Tyr Leu Arg Arg
65 70 75 80

Ile Gln Gln Ala Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro
85 90 95

Asn Val Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly
100 105 110

Asp Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His
115 120 125

Ala Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu
130 135 140

Ala Leu Tyr Gly Ala Ile Pro Trp Arg Ala Val Pro Met Met Pro Val
145 150 155 160

Glu Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val
165 170 175

Ser Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala
180 185 190

Lys Arg Pro Leu Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu
195 200 205

Phe Ile Asp Pro Pro Val Asn Ala Gly Leu Leu Pro Arg Gln Gly His
210 215 220

Gln Ser Ala Gly Trp Phe Ala Phe Phe Arg Val Val Asp His Val Leu
225 230 235 240

Arg Ala Val Asp Gly Leu Phe Pro Lys Tyr Thr Arg Glu Arg Ala Ile
245 250 255

Arg Gln Ala Val Ser Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly
260 265 270

Leu Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Asp
275 280 285

Val Leu Gly Tyr Ala Glu Asp His Pro Asn Arg Ala Ile Ala Arg Lys
290 295 300

Ser Ile Glu Lys Leu Leu Val Val His Asp Asp Glu Ala Tyr Cys Gln
305 310 315 320

Pro Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu
325 330 335

Leu Glu Thr Gly Asp Pro Arg Ala Glu Asp Ala Ala Leu Arg Gly Leu
340 345 350

Glu Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp Trp Ile
355 360 365

Ser Arg Arg Pro Asn Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala
370 375 380

Asn Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Ala
385 390 395 400

Met Asp Arg Ala Gln Lys Leu Arg Gln Ser Asp Thr Tyr Arg Glu Ser
405 410 415

Ile Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly
420 425 430

Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn
435 440 445

Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp
450 455 460

Val Ser Gly Arg Cys Leu Ser Met Leu Ser Gln Leu Gly Glu Ser Ala
465 470 475 480

Leu Thr Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu
485 490 495

Gln Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Val
500 505 510

Tyr Gly Thr Trp Thr Ala Leu Cys Ala Leu Asn Ala Ala Gly Leu Gly
515 520 525

Pro Asp Asp Pro Arg Val Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile
530 535 540

Gln Asn Lys Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu
545 550 555 560

Asn Tyr Arg Gly Tyr Glu Gln Ala Pro Ser Thr Ala Ser Gln Thr Ala
565 570 575

Trp Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asn Asn Pro Ala
580 585 590

Val Ala Arg Gly Ile Asp Tyr Leu Leu Ala Glu Gln Lys Glu His Gly
595 600 605

Leu Trp Asp Glu Val Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe
610 615 620

Tyr Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu
625 630 635 640

Ala Arg Tyr Arg Asn Leu Lys Arg Ala Asn Ala Thr Arg Val Thr Val
645 650 655

Gly Met


<210> 89
<211> 776
<212> PRT
<213> Burkholderia glumae

<400> 89
Met Asn Asp Leu Thr Asn Ser Ser Ala Pro Gly Ala Arg Pro Asp Asp
1 5 10 15

Ala Thr Pro Ser Ala Ala Gly Pro Thr Pro Ala Glu Ala Ala Gly Gly
20 25 30

Ala Val Ala Pro Ser Arg Ala Val Gln Pro Ala Asp Thr Gln Thr Ala
35 40 45

Ala Thr Gly Ala Ala Gly Ala Ala Ala Ala Val Gly Ala Thr Pro Ala
50 55 60

Glu Leu Ala Ala Thr Ala Pro Ala Ser Ser Gly Thr Pro Ala Gly Ala
65 70 75 80

Ser Ala Ala Pro Ala Pro Ser Gly Thr Pro Ser Val Asp Ala Pro Ala
85 90 95

Glu Leu Ala Ser Ala Ala Pro Ala Pro Ser Gly Ala Thr Pro Ala Ala
100 105 110

Thr Ala Thr Ala Ala Thr Ala Pro Ala Pro Ala Arg Ala Ala Ser Ile
115 120 125

Asp Ala Pro Ala Leu Ala Ala Ala Asp Leu Asp Ala Ala Ile Thr Arg
130 135 140

Ala Thr Asp Ala Leu Leu Ala Ala Gln Gln Ala Asp Gly His Trp Ile
145 150 155 160

Tyr Glu Leu Glu Ala Asp Ser Thr Ile Pro Ala Glu Tyr Val Leu Leu
165 170 175

Val His Tyr Leu Gly Glu Thr Pro Asn Leu Glu Leu Glu Arg Lys Ile
180 185 190

Ala Arg Tyr Leu Arg Arg Val Gln Leu Pro Gly Gly Gly Trp Pro Leu
195 200 205

Phe Thr Asp Gly Ala Pro Asp Val Ser Ala Ser Val Lys Ala Tyr Phe
210 215 220

Ala Leu Lys Met Ile Gly Asp Asp Ala Asn Ala Glu His Met Val Arg
225 230 235 240

Ala Arg Asn Ala Ile His Ala Met Gly Gly Ala Glu Met Ser Asn Val
245 250 255

Phe Thr Arg Ile Gln Leu Ala Leu Phe Gly Val Val Pro Trp Phe Ala
260 265 270

Val Pro Met Met Pro Val Glu Ile Met Leu Leu Pro Gln Trp Phe Pro
275 280 285

Phe His Leu Ser Lys Val Ser Tyr Trp Ala Arg Thr Val Thr Val Pro
290 295 300

Leu Leu Val Leu Ser Ala Lys Arg Pro Leu Ala Arg Asn Pro Arg Gly
305 310 315 320

Val Arg Val Asp Glu Leu Phe Val Ala Pro Pro Val Asn Ala Gly Leu
325 330 335

Leu Pro Arg Ala Gly His Gln Ser Pro Ala Trp Phe Ala Cys Phe Arg
340 345 350

Leu Leu Asp Gly Leu Leu Arg Leu Thr Asp Gly Leu Phe Pro Arg Tyr
355 360 365

Thr Arg Glu Arg Ala Ile Arg Gln Ala Leu Gln Phe Val Asp Glu Arg
370 375 380

Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Asn
385 390 395 400

Ser Val Met Met Tyr Ala Ala Leu Gly Tyr Pro Glu Asp His Pro Asn
405 410 415

Arg Ala Thr Ala Arg Arg Ala Ile Glu Lys Leu Leu Val Ile His Asp
420 425 430

Asp Glu Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ser
435 440 445

Leu Ala Ala His Ala Leu Leu Glu Thr Gly Glu Pro Arg Ala Glu Ala
450 455 460

Ala Ala Ile Arg Gly Leu Asp Trp Leu Arg Pro Leu Gln Ile Leu Asp
465 470 475 480

Val Arg Gly Asp Trp Ile Ser Arg Arg Pro Asp Val Arg Pro Gly Gly
485 490 495

Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Val Asp Asp Thr
500 505 510

Ala Val Val Thr Leu Ala Met Asp Arg Val Ala Lys Leu Ala Gln Thr
515 520 525

Asp Ala Tyr Arg Asp Ala Ile Ala Arg Ala Arg Glu Trp Val Val Gly
530 535 540

Met Gln Ser Ser Asp Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr
545 550 555 560

His Gln Tyr Leu Asn Ser Ile Pro Phe Ser Asp His Gly Ala Leu Leu
565 570 575

Asp Pro Pro Thr Ala Asp Val Ser Gly Arg Cys Leu Ser Met Leu Ala
580 585 590

Gln Leu Gly Glu Thr Ala Ala Asn Ser Ala Pro Ala Arg Arg Ala Leu
595 600 605

Asp Tyr Leu Leu Ala Glu Gln Gly Ala Asp Gly Ser Trp Tyr Gly Arg
610 615 620

Trp Gly Met Asn Tyr Ile Tyr Gly Thr Trp Ser Ala Leu Gly Ala Leu
625 630 635 640

Asn Ala Ala Gly Leu Pro Phe Asp Asp Pro Arg Val Lys Arg Ala Ala
645 650 655

Gln Trp Leu Leu Ser Ile Gln Asn Pro Asp Gly Gly Trp Gly Glu Asp
660 665 670

Gly Asp Ser Tyr Lys Leu Asp Tyr Arg Gly Tyr Glu Arg Ala Ala Ser
675 680 685

Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala Gly
690 695 700

Glu Val Glu His Pro Ala Val Ala Arg Gly Ile Ala Trp Leu Ala Ala
705 710 715 720

Gln Gln Arg Glu His Gly Leu Trp Asp Glu Ala Arg Phe Thr Ala Thr
725 730 735

Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Lys Phe
740 745 750

Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu Arg Arg Thr Gly
755 760 765

Thr Arg Arg Val Thr Val Gly Met
770 775


<210> 90
<211> 676
<212> PRT
<213> Burkholderia glumae

<400> 90
Met Ile Arg Pro Met Lys Asn Ser Asp Leu Pro Leu Pro Ser Leu Leu
1 5 10 15

Asp Ala Ala Ile Leu Arg Gly Arg Asp Ala Leu Ala Gln Arg Gln Ser
20 25 30

Ala Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Gly Lys Ile Asp Glu Ala
50 55 60

Arg Gln Ala Arg Met Ala Arg Tyr Leu Arg Gly Ile Gln Arg Leu Ala
65 70 75 80

Thr His Gly Ala Trp Asp Leu Tyr Val Asp Gly Ala Pro Asp Val Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

Asp Ala Pro His Met Ala Arg Ala Arg Glu Thr Ile Leu Lys Leu Gly
115 120 125

Gly Ala Ala Lys Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Thr Pro Phe Met Pro Val Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Ala Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

Arg Ala Lys Asn Pro Arg Asn Val Ser Ile Arg Glu Leu Phe Val Thr
195 200 205

Ala Pro Glu Ala Glu Arg His Tyr Phe Ala Arg Gly Gly Phe Val Arg
210 215 220

Asn Leu Phe Leu Gly Ile Asp Arg Ala Leu Arg Pro Leu Asp Ala Leu
225 230 235 240

Ile Pro Lys Ala Leu Arg Arg Arg Ala Ile Arg His Ala Glu Ala Trp
245 250 255

Cys Ala Glu Arg Met Asn Gly Glu Asp Gly Met Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Ser Tyr Gln Met Met Asp Val Leu Gly Tyr Pro Glu
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Asp Lys Leu Leu
290 295 300

Val Glu Arg Pro Asp Gly Ser Val Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Ala
325 330 335

Val Pro Asp Pro Arg Asp Ala Pro Pro Val Ser Asp Ala Gln Leu Gln
340 345 350

Arg Cys Ile Ala Ala Ser Tyr Glu Trp Leu Ala Gly Lys Gln Val Thr
355 360 365

Gln Val Arg Gly Asp Trp Val Glu Asn Ala Pro Ala Ala Thr Pro Ala
370 375 380

Gly Gly Trp Ala Phe Gln Tyr Glu Asn Pro Tyr Tyr Pro Asp Ile Asp
385 390 395 400

Asp Ser Ala Val Val Ala Ala Met Leu His Arg Arg Gly Arg Leu Leu
405 410 415

Ala Arg Ser Thr Gly Thr Asp Pro Tyr Ala Gln Val Val Ala Arg Gly
420 425 430

Leu Asp Trp Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe Gly Ala
435 440 445

Phe Asp Ala Asp Cys Asp Arg Leu Tyr Leu Asn Leu Ile Pro Phe Ala
450 455 460

Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly Arg
465 470 475 480

Val Leu Leu Cys Leu Gly Val Thr Gly Arg Asp Glu Asp Lys Pro Ala
485 490 495

Leu Ala Arg Ala Ile Glu Tyr Val Lys Arg Met Gln Arg Ala Asp Gly
500 505 510

Cys Trp Trp Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser
515 520 525

Val Leu Ala Gly Leu Ala Leu Ala Gly Glu Asn Pro Ser Gln Pro Tyr
530 535 540

Ile Ala Arg Ala Ile Ala Trp Leu Arg Ala Cys Gln Asn Ala Asp Gly
545 550 555 560

Gly Trp Gly Glu Thr Asn Asp Ser Tyr Leu Asp Pro Ala Leu Ala Gly
565 570 575

Thr Asn Gly Gly Glu Ser Ala Ser Asn Val Thr Ala Trp Ala Leu Leu
580 585 590

Ala Gln Met Ala Phe Gly Asp Trp Gln Ser Glu Ser Val Gln Arg Gly
595 600 605

Ile Arg Tyr Leu Leu Ser Val Gln Gln Ala Asp Gly Phe Trp Trp His
610 615 620

Arg Ser His Asn Ala Pro Gly Phe Pro Arg Ile Tyr Tyr Leu Lys Tyr
625 630 635 640

His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg
645 650 655

Arg Leu Ser Gln Ala Gly Ala Ala Arg Asp Val Thr Asp Gly Ala Ala
660 665 670

Leu Ala Ala Ser
675


<210> 91
<211> 683
<212> PRT
<213> Burkholderia graminis

<400> 91
Met Asn Asp Leu Ser Gln Ala His Val Leu Gly Ala Ala Met Pro Glu
1 5 10 15

Thr Ala Gly Glu Ala Gln Asn Ala Gln Ala Ala Ala Asn Ser Ala Ala
20 25 30

Ala Ala Ala Glu Ala Ser Ala Val Leu Ala Pro Ser Leu Asp Ala Ala
35 40 45

Ile Thr Arg Ala Thr Asp Ala Ile Leu Ala Ala Gln Lys Pro Asp Gly
50 55 60

His Trp Val Tyr Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr
65 70 75 80

Val Leu Leu Val His Tyr Leu Gly Glu Thr Pro Asn Val Glu Leu Glu
85 90 95

Gln Lys Ile Ala Arg Tyr Leu Arg Arg Ile Gln Leu Pro Asn Gly Gly
100 105 110

Trp Pro Leu Phe Thr Asp Gly Ala Ile Asp Ile Ser Ala Ser Val Lys
115 120 125

Ala Tyr Phe Ala Leu Lys Met Ile Gly Asp Pro Val Asp Ala Glu His
130 135 140

Met Val Arg Ala Arg Glu Ala Ile Leu Ala His Gly Gly Ala Glu Thr
145 150 155 160

Val Asn Val Phe Thr Arg Ile Leu Leu Ala Leu Phe Gly Val Val Ser
165 170 175

Trp Arg Ala Val Pro Met Met Pro Val Glu Ile Thr Leu Leu Pro Met
180 185 190

Trp Phe Pro Phe His Leu Ser Lys Val Ser Tyr Trp Ala Arg Thr Val
195 200 205

Ile Val Pro Leu Leu Val Leu Asn Ala Lys Arg Pro Leu Ala Arg Asn
210 215 220

Pro Arg Arg Val Arg Ile Asp Glu Leu Phe Arg Gly Ala Pro Val Asn
225 230 235 240

Thr Gly Met Pro Ala Arg Ala Pro His Gln His Val Gly Trp Phe Gly
245 250 255

Phe Phe Arg Val Val Asp Thr Val Leu Arg Ala Val Asp Gly Leu Phe
260 265 270

Pro Lys Ala Thr Arg Glu Arg Ala Val Arg Glu Ala Val Ala Phe Val
275 280 285

Asp Gln Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ala
290 295 300

Met Ala Asn Ser Val Met Met Tyr Asp Val Leu Gly Tyr Pro Ala Asp
305 310 315 320

His Pro Asn Arg Ala Ile Ala Arg Arg Ser Ile Glu Lys Leu Leu Val
325 330 335

Ile Lys Asp Asp Glu Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp
340 345 350

Asp Thr Ser Leu Ala Ala His Ala Leu Leu Glu Thr Gly Asp Ala Arg
355 360 365

Ala Glu Gln Ala Ala Glu Arg Gly Leu Ala Trp Leu Arg Pro Leu Gln
370 375 380

Ile Leu Asp Val Arg Gly Asp Trp Ile Ser Arg Arg Pro Asn Val Arg
385 390 395 400

Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala Tyr Tyr Pro Asp Val
405 410 415

Asp Asp Thr Ala Val Val Ala Met Ala Met His Arg Ser Glu Ala Leu
420 425 430

Thr His Ser Gly Ala Asp Arg Glu Ala Ile Ala Arg Ala Arg Glu Trp
435 440 445

Val Val Gly Met Gln Ser Ser Asp Gly Gly Trp Gly Ala Phe Glu Pro
450 455 460

Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile Pro Phe Ser Asp His Gly
465 470 475 480

Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser Gly Arg Cys Leu Ser
485 490 495

Met Leu Ala Gln Leu Gly Glu Phe Pro Gln Asn Ser Glu Pro Ala Gln
500 505 510

Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln Glu Ala Asp Gly Ser Trp
515 520 525

Tyr Gly Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp Thr Ala Leu
530 535 540

Cys Ser Leu Asn Ala Ala Gly Leu Pro His Asp Asp Pro Arg Ile Arg
545 550 555 560

Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln Asn Glu Asp Gly Gly Trp
565 570 575

Gly Glu Gly Gly Glu Ser Tyr Lys Leu Asp Tyr Arg Gly Tyr Glu Arg
580 585 590

Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Met
595 600 605

Ala Ala Gly Glu Val Asp His Glu Ala Val Ala Arg Gly Ile Glu Tyr
610 615 620

Leu Gln Arg Glu Gln Arg Glu His Gly Leu Trp Asp Glu Thr Arg Phe
625 630 635 640

Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr
645 650 655

Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg His Leu Lys
660 665 670

Arg Asn Gly Leu Thr Arg Val Ala Val Gly Met
675 680


<210> 92
<211> 657
<212> PRT
<213> Burkholderia mallei

<400> 92
Met Asn Asp Met Thr Glu Met His Thr Leu Asp Ala Thr Ala Ala Pro
1 5 10 15

Ala Gly Leu Asp Ala Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Gln Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu Ala
50 55 60

Pro Asn Val Glu Leu Glu Gln Lys Ile Ala Arg Tyr Leu Arg Arg Ile
65 70 75 80

Gln Gln Pro Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Tyr Gly Val Val Pro Trp Tyr Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Val Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe
195 200 205

Lys Gly Ala Pro Val Ser Thr Gly Leu Leu Pro Lys Gln Pro His Gln
210 215 220

Ser Ala Gly Trp Phe Ala Phe Phe Arg Ala Val Asp Gly Val Leu Arg
225 230 235 240

Leu Val Asp Gly Leu Phe Pro Arg Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ala Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Ala Ala
275 280 285

Leu Gly Tyr Pro Glu Asp His Pro Asn Arg Ala Ile Ala Arg Arg Ser
290 295 300

Ile Glu Lys Leu Leu Val Val Gly Glu Gln Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu
325 330 335

Glu Thr Gly Asp Ala Arg Ala Arg Glu Ala Ala Val Arg Gly Leu Asp
340 345 350

Trp Leu Val Pro Arg Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro His Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Ala Met
385 390 395 400

Asp Arg Val Ala Lys Leu Asp Arg Thr Asp Ala Tyr Arg Glu Ser Ile
405 410 415

Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ala Gln Phe Gly Glu Thr Ser Ala
465 470 475 480

Ser Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Ile Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly Leu Gly His
515 520 525

Asp Asp Pro Arg Val Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln
530 535 540

Asn Ala Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asp
545 550 555 560

Tyr Arg Gly Tyr Glu Arg Ala Pro Ser Thr Ser Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asp Asn Pro Ala Val
580 585 590

Ala Arg Gly Val Asp Tyr Leu Leu Gly Thr Gln Arg Glu His Gly Leu
595 600 605

Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Ala Asn Ala Met Arg Val Thr Val Gly
645 650 655

Met


<210> 93
<211> 683
<212> PRT
<213> Burkholderia multivorans

<400> 93
Met Ile Arg Ala Met Asn Lys Ser Ala Leu Ser Pro Trp Ser Ala Leu
1 5 10 15

Asp Thr Ala Ile Ala Arg Gly Arg Asp Ala Leu Ala Arg Leu Gln Gln
20 25 30

Pro Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Asp Arg Ile Asp Asp Ala
50 55 60

Leu Gln Glu Arg Met Ala Arg Tyr Leu Arg Ala Ile Gln Arg Leu Asp
65 70 75 80

Thr His Gly Ala Trp Asp Leu Tyr Val Asp Gly Ala Pro Asp Val Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

His Ala Pro His Met Ile Arg Ala Arg Glu Ala Ile Leu Lys Leu Gly
115 120 125

Gly Ala Ala Arg Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Thr Pro Phe Met Pro Ile Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Ala Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

Arg Ala Arg Asn Pro Arg Asn Val Ala Ile Pro Glu Leu Phe Val Thr
195 200 205

Pro Pro Asp Gln Glu Arg His Tyr Phe Pro Pro Thr Arg Gly Met Arg
210 215 220

Arg Ala Phe Leu Ile Leu Asp Arg Val Val Arg His Val Glu Pro Leu
225 230 235 240

Leu Pro Lys Arg Leu Arg Arg Arg Ala Ile Arg His Ala Glu Ala Trp
245 250 255

Cys Ala Gln Arg Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Ser Tyr Gln Met Met Asp Val Leu Gly Tyr Pro Glu
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Ala Lys Leu Leu
290 295 300

Val Thr Arg Pro Asp Gly Ser Val Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Ser
325 330 335

Val Ala Val Pro Glu Ser Asp Glu Ser Ala Arg Ala Leu Asp Glu Leu
340 345 350

Asp Ala Arg Ile Ala Arg Ala Tyr Asp Trp Leu Ala Thr Arg Gln Val
355 360 365

Asn Asp Leu Arg Gly Asp Trp Ile Glu Asn Ala Pro Ala Asp Thr Gln
370 375 380

Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp Ile
385 390 395 400

Asp Asp Ser Ala Val Val Thr Ala Met Leu Asp Arg Arg Gly Arg Thr
405 410 415

His Arg Asn Ala Asp Gly Ser His Pro Tyr Ala Ala Arg Val Ala Arg
420 425 430

Ala Leu Asp Trp Met Arg Ala Leu Gln Ser Arg Asn Gly Gly Phe Ala
435 440 445

Ala Phe Asp Ala Asp Cys Asp Arg Leu Tyr Leu Asn Ala Ile Pro Phe
450 455 460

Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly
465 470 475 480

Arg Val Leu Leu Cys Phe Gly Val Thr Arg Arg Ala Glu Asp Arg Ala
485 490 495

Ser Leu Ala Arg Ala Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro Asp
500 505 510

Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr Trp
515 520 525

Ser Val Leu Ala Gly Leu Thr Leu Ala Gly Glu Asp Pro Ser Gln Pro
530 535 540

Tyr Ile Ala Arg Ala Leu Glu Trp Leu Arg Ala His Gln His Ala Asp
545 550 555 560

Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Leu Asp Pro Ala Leu Ala
565 570 575

Gly Thr Asn Gly Gly Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala Leu
580 585 590

Leu Ala Gln Met Ala Phe Gly Asp Cys Ala Ser Asp Ser Val Lys Arg
595 600 605

Gly Ile Ala Tyr Leu Gln Ser Val Gln Gln Asp Asp Gly Phe Trp Trp
610 615 620

His Arg Ser His Asn Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu Lys
625 630 635 640

Tyr His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr
645 650 655

Arg Arg Leu Ala Gly Ala Ala Glu Ala Arg Ala Arg Ala Ser Ser Gly
660 665 670

Arg Ala Pro His Ala Ala Asp Thr Ala Leu Ala
675 680


<210> 94
<211> 657
<212> PRT
<213> Burkholderia multivorans

<400> 94
Met Asn Asp Leu Thr Asp Met Ala Thr Leu Ser Ala Gly Thr Val Pro
1 5 10 15

Ala Glu Leu Asp Ala Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Asn Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu Thr
50 55 60

Pro Asn Leu Glu Leu Glu Gln Lys Ile Gly Arg Tyr Leu Arg Arg Ile
65 70 75 80

Gln Gln Ala Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Tyr Gly Ala Ile Pro Trp Arg Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Leu Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe
195 200 205

Ile Asp Pro Pro Val Asn Ala Gly Leu Leu Pro Arg Gln Gly His Gln
210 215 220

Ser Ala Gly Trp Phe Ala Phe Phe Arg Ala Val Asp His Val Leu Arg
225 230 235 240

Ala Val Asp Gly Leu Phe Pro Ala Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ala Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Asp Val
275 280 285

Leu Gly Tyr Ala Glu Asp His Pro Asn Arg Ala Ile Ala Arg Lys Ser
290 295 300

Ile Glu Lys Leu Leu Val Val His Glu Asp Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu
325 330 335

Glu Thr Arg Asp Pro Arg Ala Glu Gln Ala Ala Val Arg Gly Leu Asp
340 345 350

Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro His Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Pro His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Ala Met
385 390 395 400

Asp Arg Ala Gln Lys Leu Asn Gln Ser Asp Thr Tyr Arg Glu Ser Ile
405 410 415

Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ser Gln Leu Gly Glu Thr Ala Leu
465 470 475 480

Asn Ser Asp Ala Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Val Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ala Leu Asn Ala Ala Gly Leu Gly Pro
515 520 525

Asp Asp Ala Arg Val Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln
530 535 540

Asn Lys Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asn
545 550 555 560

Tyr Arg Gly Tyr Glu Pro Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asn Asn Pro Ala Val
580 585 590

Lys Arg Gly Ile Asp Tyr Leu Ile Ala Glu Gln Lys Glu His Gly Leu
595 600 605

Trp Asp Glu Ala Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Asp Asn Thr Thr Arg Val Thr Val Gly
645 650 655

Ile


<210> 95
<211> 668
<212> PRT
<213> Burkholderia oklahomensis

<400> 95
Met Asn Asp Met Thr Glu Met His Thr Leu Asp Ala Ala Ala Ala Pro
1 5 10 15

Ala Ala Asp Ala Pro Ala Val Thr Ala Val Thr Ala Gly Leu Asp Ala
20 25 30

Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala Ala Gln Asn Ala Asp
35 40 45

Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser Thr Ile Pro Ala Glu
50 55 60

Tyr Val Leu Leu Val His Tyr Leu Gly Glu Glu Pro Asn Ala Glu Leu
65 70 75 80

Glu Gln Lys Ile Ala Arg Tyr Leu Arg Arg Ile Gln Gln Pro Asp Gly
85 90 95

Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn Val Ser Ala Ser Val
100 105 110

Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp Asp Glu Asn Ala Glu
115 120 125

His Met Gln Arg Ala Arg Arg Ala Ile His Ala Met Gly Gly Ala Glu
130 135 140

Thr Ser Asn Val Phe Thr Arg Ile Gln Leu Ala Leu Tyr Gly Val Val
145 150 155 160

Pro Trp Tyr Ala Val Pro Met Met Pro Val Glu Val Met Leu Leu Pro
165 170 175

Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser Tyr Trp Ala Arg Thr
180 185 190

Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys Arg Pro Val Ala Lys
195 200 205

Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe Lys Ser Ala Pro Val
210 215 220

Asn Thr Gly Leu Leu Pro Lys Gln Pro His Gln Ser Thr Gly Trp Phe
225 230 235 240

Ala Phe Phe Arg Ala Val Asp Gly Val Leu Arg Leu Val Asp Gly Leu
245 250 255

Phe Pro Arg Tyr Thr Arg Glu Arg Ala Ile Arg Gln Ala Val Ala Phe
260 265 270

Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro
275 280 285

Ala Met Ala Asn Ala Val Met Met Tyr Ala Ala Leu Gly Tyr Pro Glu
290 295 300

Asp His Pro Asn Arg Ala Ile Ala Arg Gln Ser Ile Glu Lys Leu Leu
305 310 315 320

Val Val Gly Glu Glu Glu Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val
325 330 335

Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu Glu Thr Gly Asp Glu
340 345 350

Arg Ala Arg Asp Ala Ala Val Arg Gly Leu Asp Trp Leu Ile Pro Arg
355 360 365

Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser Arg Arg Pro His Val
370 375 380

Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp
385 390 395 400

Val Asp Asp Thr Ala Val Val Val Met Ala Met Asp Arg Val Ala Lys
405 410 415

Leu Asp Gln Ser Asp Ala Tyr Arg Glu Gln Ile Ala Arg Ala Arg Glu
420 425 430

Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly Trp Gly Ala Phe Glu
435 440 445

Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile Pro Phe Ser Asp His
450 455 460

Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser Gly Arg Cys Leu
465 470 475 480

Ser Met Leu Ala Gln Leu Gly Glu Thr Asn Ala Ser Ser Glu Pro Ala
485 490 495

Arg Arg Ala Phe Asp Tyr Met Leu Lys Glu Gln Glu Pro Asp Gly Ser
500 505 510

Trp Tyr Gly Arg Trp Gly Met Asn Tyr Ile Tyr Gly Thr Trp Thr Ala
515 520 525

Leu Cys Ala Leu Asn Ala Ala Gly Leu Gly His Asp Asp Pro Arg Val
530 535 540

Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln Asn Gln Asp Gly Gly
545 550 555 560

Trp Gly Glu Asp Gly Glu Ser Tyr Lys Leu Asp Tyr Arg Gly Tyr Glu
565 570 575

Arg Ala Pro Ser Ser Ser Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu
580 585 590

Met Ala Ala Gly Glu Val Asp Asn Pro Val Val Ala Arg Gly Ile Asp
595 600 605

Tyr Leu Leu Gly Ala Gln Cys Glu His Gly Leu Trp Asp Glu Thr Arg
610 615 620

Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly
625 630 635 640

Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu
645 650 655

Lys Arg Ala Asn Thr Thr Arg Val Thr Val Gly Met
660 665


<210> 96
<211> 677
<212> PRT
<213> Burkholderia phymatum

<400> 96
Met Asn Asp Leu Ser Met Thr Gln Thr Leu Gly Glu Val Leu Pro Gln
1 5 10 15

Thr Leu Ile Asp Asp His Ala Pro Val Ala Ala Ala Leu Ala Thr Gly
20 25 30

Ala Ala Pro Val Asp Ala Leu Asp Ala Ala Val Thr Arg Ala Thr Glu
35 40 45

Ala Ile Leu Ala Val Gln Lys Asp Asp Gly His Trp Val Tyr Glu Leu
50 55 60

Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Phe
65 70 75 80

Leu Gly Glu Thr Pro Asn Leu Glu Leu Glu Gln Lys Ile Ala Arg Tyr
85 90 95

Leu Arg Arg Ile Gln Leu Pro Asn Gly Gly Trp Pro Leu Phe Thr Asp
100 105 110

Gly Ala Met Asp Val Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys
115 120 125

Met Ile Gly Asp Pro Glu Asp Ala Ala His Met Val Arg Ala Arg Glu
130 135 140

Cys Ile Leu Ala Asn Gly Gly Ala Glu Ala Ala Asn Val Phe Thr Arg
145 150 155 160

Ile Leu Leu Ala Leu Phe Gly Val Val Thr Trp Tyr Ala Val Pro Met
165 170 175

Met Pro Val Glu Ile Met Leu Leu Pro Lys Trp Phe Pro Phe His Leu
180 185 190

Ser Lys Val Ser Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val
195 200 205

Leu Asn Ala Lys Arg Pro Val Ala Arg Asn Pro Arg Gly Val Arg Ile
210 215 220

Asp Glu Leu Phe Arg Gly Ala Pro Val Thr Thr Gly Leu Leu Pro Arg
225 230 235 240

Ser Gly His Gln Ser Lys Ser Trp Phe Ala Phe Phe Arg Ala Val Asp
245 250 255

Gly Val Leu Arg Val Thr Asp Gly Leu Phe Pro Lys Ala Ser Arg Glu
260 265 270

Arg Ala Ile Lys Ala Ala Val Ser Phe Val Asp Glu Arg Leu Asn Gly
275 280 285

Val Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Ala Asn Ser Val Met
290 295 300

Met Tyr Asp Val Leu Gly Tyr Pro Ala Asp His Pro Asn Arg Ala Ile
305 310 315 320

Ala Arg Glu Ser Ile Glu Lys Leu Leu Val Val His Glu Asp Glu Ala
325 330 335

Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala
340 345 350

His Ala Leu Leu Glu Thr Gly Asp Ala Arg Ala Glu Glu Ala Ala Glu
355 360 365

Arg Gly Leu Ala Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly
370 375 380

Asp Trp Ile Ser Arg Arg Pro Asp Val Arg Pro Gly Gly Trp Ala Phe
385 390 395 400

Gln Tyr Asn Asn Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val
405 410 415

Ala Met Ala Met His Arg Ser Ala Ala Val Thr Asn Ser Asn Val Asp
420 425 430

Ala Asn Ala Ile Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser
435 440 445

Ser Asp Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr
450 455 460

Leu Asn Asn Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro
465 470 475 480

Thr Ala Asp Val Ser Gly Arg Cys Leu Ser Met Leu Ala Gln Leu Gly
485 490 495

Glu Met Pro Ala Thr Ser Glu Pro Ala Arg Arg Ala Tyr Asp Tyr Leu
500 505 510

Leu Lys Glu Gln Glu Asp Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met
515 520 525

Asn Tyr Ile Tyr Gly Thr Trp Thr Ala Leu Cys Ala Leu Asn Ala Ala
530 535 540

Gly Ile Ser Leu Glu Asp Ala Arg Ile Lys Arg Ala Ala Gln Trp Leu
545 550 555 560

Val Ser Ile Gln Asn Ala Asp Gly Gly Trp Gly Glu Asp Gly Thr Ser
565 570 575

Tyr Lys Leu Asp Tyr Arg Gly Tyr Glu Lys Ala Pro Ser Ile Pro Ser
580 585 590

Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala Gly Tyr Val Asp
595 600 605

His Pro Ala Val Ala Arg Gly Ile Asp Tyr Leu Gln Arg Glu Gln Arg
610 615 620

Asp His Gly Leu Trp Asp Glu Glu Arg Phe Ser Ala Thr Gly Phe Pro
625 630 635 640

Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Lys Tyr Phe Pro Leu
645 650 655

Trp Ala Leu Ala Arg Tyr Arg Asn Leu Lys Arg Thr Gly Glu Lys Arg
660 665 670

Val Thr Val Gly Met
675


<210> 97
<211> 676
<212> PRT
<213> Burkholderia phytofirmans

<400> 97
Met Asn Asp Leu Ser Gln Ala Gln Pro Leu Asp Ala Ile Leu Pro Asp
1 5 10 15

Phe Ala Asp Ala Ala Pro Ser Ala Pro Ala Pro Ala Val Thr Gly Glu
20 25 30

Ala Pro Thr Ala Ser Leu Asp Ala Ala Ile Thr Arg Ala Thr Glu Ala
35 40 45

Ile Leu Ala Ala Gln Lys Pro Asp Gly His Trp Val Tyr Glu Leu Glu
50 55 60

Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu
65 70 75 80

Gly Glu Thr Pro Asn Leu Glu Leu Glu Gln Lys Ile Ala Arg Tyr Leu
85 90 95

Arg Arg Ile Gln Leu Pro Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly
100 105 110

Ala Leu Asp Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Met
115 120 125

Ile Gly Asp Pro Ala Asp Ala Glu His Met Val Arg Ala Arg Glu Ala
130 135 140

Ile Leu Ala His Gly Gly Ala Glu Thr Val Asn Val Phe Thr Arg Ile
145 150 155 160

Leu Leu Ala Leu Phe Gly Val Val Ser Trp Arg Ala Val Pro Met Met
165 170 175

Pro Val Glu Ile Met Leu Leu Pro Met Trp Phe Pro Phe His Leu Ser
180 185 190

Lys Val Ser Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu
195 200 205

Asn Ala Lys Arg Pro Val Ala Arg Asn Pro Arg Arg Val Arg Ile Asp
210 215 220

Glu Leu Phe Arg Gly Ala Pro Val Asn Thr Gly Pro Arg Asp Arg Ala
225 230 235 240

Pro His Gln His Ala Gly Trp Phe Arg Phe Phe Ser Gly Val Asp Val
245 250 255

Leu Leu Arg Ala Val Asp Gly Leu Phe Pro Lys Ser Thr Arg Glu Arg
260 265 270

Ala Val Arg Gln Ala Val Ala Phe Val Asp Glu Arg Leu Asn Gly Glu
275 280 285

Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Ala Asn Ser Val Met Met
290 295 300

Tyr Asp Val Leu Gly Tyr Pro Ala Asp His Pro Asn Arg Ala Ile Ala
305 310 315 320

Arg Gln Ser Ile Asp Lys Leu Leu Val Ile Lys Asp Asp Glu Ala Tyr
325 330 335

Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His
340 345 350

Ala Leu Leu Glu Thr Gly Glu Ala His Ala Glu Gln Ala Ala Glu Arg
355 360 365

Gly Leu Ala Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp
370 375 380

Trp Ile Ser Arg Arg Pro Asn Val Arg Pro Gly Gly Trp Ala Phe Gln
385 390 395 400

Tyr Asn Asn Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala
405 410 415

Met Ala Met Gln Arg Ser Ala Thr Val Thr Gln Ser Asp Val Asp Arg
420 425 430

Asp Ala Ile Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser
435 440 445

Asp Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu
450 455 460

Asn Asn Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr
465 470 475 480

Ala Asp Val Ser Gly Arg Cys Leu Ser Met Leu Ala Gln Leu Gly Glu
485 490 495

Leu Pro Gln Asn Ser Glu Pro Ala Gln Arg Ala Phe Asp Tyr Met Leu
500 505 510

Lys Glu Gln Glu Ser Asp Gly Ser Trp Tyr Gly Arg Trp Gly Leu Asn
515 520 525

Tyr Ile Tyr Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly
530 535 540

Leu Pro His Asp Asp Pro Arg Met Lys Arg Ala Ala Gln Trp Leu Leu
545 550 555 560

Ser Ile Gln Asn Glu Asp Gly Gly Trp Gly Glu Gly Gly Glu Ser Tyr
565 570 575

Lys Leu Asp Tyr His Gly Tyr Glu Arg Ala Pro Ser Thr Ala Ser Gln
580 585 590

Thr Ala Trp Ala Leu Met Gly Leu Met Ala Ala Gly Glu Val Asn His
595 600 605

Glu Ala Val Ala Arg Gly Val Ala Tyr Leu Glu Arg Glu Gln Arg Glu
610 615 620

His Gly Leu Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg
625 630 635 640

Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp
645 650 655

Ala Leu Ala Arg Phe Arg His Leu Lys Arg Asn Gly Leu Thr Arg Val
660 665 670

Ala Val Gly Met
675


<210> 98
<211> 657
<212> PRT
<213> Burkholderia pseudomallei

<400> 98
Met Asn Asp Met Thr Glu Met His Thr Leu Asp Ala Thr Ala Ala Pro
1 5 10 15

Ala Gly Leu Asp Ala Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Gln Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu Ala
50 55 60

Pro Asn Val Glu Leu Glu Gln Lys Ile Ala Arg Tyr Leu Arg Arg Ile
65 70 75 80

Gln Gln Pro Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Tyr Gly Val Val Pro Trp Tyr Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Val Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe
195 200 205

Lys Gly Ala Pro Val Ser Thr Gly Leu Leu Pro Lys Gln Pro His Gln
210 215 220

Ser Ala Gly Trp Phe Ala Phe Phe Arg Ala Val Asp Gly Val Leu Arg
225 230 235 240

Leu Val Asp Gly Leu Phe Pro Arg Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ala Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Ala Ala
275 280 285

Leu Gly Tyr Pro Glu Asp His Pro Asn Arg Ala Ile Ala Arg Arg Ser
290 295 300

Ile Glu Lys Leu Leu Val Val Gly Glu Gln Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu
325 330 335

Glu Thr Gly Asp Ala Arg Ala Arg Glu Ala Ala Val Arg Gly Leu Asp
340 345 350

Trp Leu Val Pro Arg Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro His Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Ala Met
385 390 395 400

Asp Arg Val Ala Lys Leu Asp Arg Thr Asp Ala Tyr Arg Glu Ser Ile
405 410 415

Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ala Gln Phe Gly Glu Thr Ser Ala
465 470 475 480

Ser Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Ile Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly Leu Gly His
515 520 525

Asp Asp Pro Arg Val Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln
530 535 540

Asn Ala Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asp
545 550 555 560

Tyr Arg Gly Tyr Glu Arg Ala Pro Ser Thr Ser Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Ala Val Asp Asn Pro Ala Val
580 585 590

Ala Arg Gly Val Asp Tyr Leu Leu Gly Thr Gln Arg Glu His Ser Leu
595 600 605

Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Ala Asn Ala Thr Arg Val Thr Val Gly
645 650 655

Met


<210> 99
<211> 681
<212> PRT
<213> Burkholderia sp.

<400> 99
Met Asn Asp Leu Ser Gln Thr Gln Pro Leu Ala Ala Val Leu Pro Glu
1 5 10 15

Ala Ala Asp Ala Pro Ala Val Ala Asp Ala Ser Ala Thr Ala Ala Pro
20 25 30

Glu Pro Val Gln Ala Ala Ser Pro Ser Ala Leu Asp Ala Ser Ile Thr
35 40 45

Arg Ala Thr Asp Thr Ile Leu Ala Ala Gln Lys Pro Asp Gly His Trp
50 55 60

Val Tyr Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu
65 70 75 80

Leu Val His Tyr Leu Gly Glu Thr Pro Asn Leu Glu Leu Glu Gln Lys
85 90 95

Ile Ala Arg Tyr Leu Arg Arg Ile Gln Leu Pro Asn Gly Gly Trp Pro
100 105 110

Leu Phe Thr Asp Gly Ala Leu Asp Ile Ser Ala Ser Val Lys Ala Tyr
115 120 125

Phe Ala Leu Lys Met Ile Gly Asp Pro Val Asp Ala Glu His Met Val
130 135 140

Arg Ala Arg Asp Ala Ile Leu Ala His Gly Gly Ala Glu Arg Ala Asn
145 150 155 160

Val Phe Thr Arg Ile Leu Leu Ala Leu Phe Gly Val Val Ser Trp Arg
165 170 175

Ala Val Pro Met Met Pro Val Glu Ile Met Leu Leu Pro Val Trp Phe
180 185 190

Pro Phe His Leu Ser Lys Val Ser Tyr Trp Ala Arg Thr Val Ile Val
195 200 205

Pro Leu Leu Val Leu Asn Ala Lys Arg Pro Leu Ala Arg Asn Pro Arg
210 215 220

Lys Val Arg Ile Asp Glu Leu Phe Arg Ala Ala Pro Val Asn Thr Gly
225 230 235 240

Met Asn Glu Arg Ala Pro His Gln His Ala Gly Trp Phe Gly Phe Phe
245 250 255

Arg Cys Val Asp Thr Val Leu Arg Ala Val Asp Gly Leu Leu Pro Lys
260 265 270

Ala Thr Arg Glu Arg Ala Ile Arg Ala Ala Val Ala Phe Val Asp Glu
275 280 285

Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Ala
290 295 300

Asn Ser Val Met Met Tyr Asp Val Leu Gly Tyr Pro Ala Asp His Pro
305 310 315 320

His Arg Ala Ile Ala Arg Lys Ser Leu Asp Lys Leu Leu Val Ile Lys
325 330 335

Asp Asp Glu Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr
340 345 350

Ser Leu Ala Ala His Ala Leu Leu Glu Thr Gly Glu Ala Arg Ala Glu
355 360 365

Gln Ala Ala Glu Arg Gly Leu Ala Trp Leu Arg Pro Leu Gln Ile Leu
370 375 380

Asp Val Arg Gly Asp Trp Ile Ser Arg Arg Pro Asn Val Arg Pro Gly
385 390 395 400

Gly Trp Ala Phe Gln Tyr Asn Asn Ala His Tyr Pro Asp Val Asp Asp
405 410 415

Thr Ala Val Val Ala Met Ala Met His Arg Ser Ala Ala Leu Thr Gln
420 425 430

Ser Asp Val Asp Arg Glu Ala Ile Ala Arg Ala Arg Glu Trp Val Val
435 440 445

Gly Met Gln Ser Ser Asp Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn
450 455 460

Thr Gln Tyr Tyr Leu Asn Asn Ile Pro Phe Ser Asp His Gly Ala Leu
465 470 475 480

Leu Asp Pro Pro Thr Ala Asp Val Ser Gly Arg Cys Leu Ser Met Phe
485 490 495

Ala Gln Ile Gly Glu Leu Pro Gln Ser Ser Glu Pro Ala Arg Arg Ala
500 505 510

Phe Asp Tyr Met Leu Gln Glu Gln Glu Pro Asp Gly Ser Trp Tyr Gly
515 520 525

Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp Thr Ala Leu Ser Ser
530 535 540

Leu Asn Ala Ala Gly Met Pro His Asp Asp Pro Arg Met Arg Arg Ala
545 550 555 560

Ala Gln Trp Leu Val Ser Ile Gln Asn Glu Asp Gly Gly Trp Gly Glu
565 570 575

Gly Gly Glu Ser Tyr Lys Leu Asp Tyr His Gly Tyr Glu Arg Ala Pro
580 585 590

Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala
595 600 605

Gly Glu Val Asn His Glu Ala Val Ala Arg Gly Ile Asp Tyr Leu Gln
610 615 620

Arg Glu Gln Arg Glu His Gly Leu Trp Asp Glu Thr Arg Phe Ser Ala
625 630 635 640

Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Lys
645 650 655

Phe Phe Pro Leu Trp Ala Leu Ala Arg Phe Arg His Leu Lys Arg His
660 665 670

Gly Leu Thr Arg Val Thr Val Gly Met
675 680


<210> 100
<211> 678
<212> PRT
<213> Burkholderia sp.

<400> 100
Met Ile Arg Arg Met Thr Thr Pro Thr Pro Ser Pro Trp Ser Ala Leu
1 5 10 15

Asp Thr Ala Ile Ala Arg Gly Arg Asp Ala Leu Val Arg Leu Gln Gln
20 25 30

Pro Asp Gly Ser Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr
35 40 45

Ala Glu Tyr Ile Leu Met Met His Phe Met Asp Lys Ile Asp Asp Leu
50 55 60

Arg Gln Glu Lys Met Ala Arg Tyr Leu Arg Ala Asn Gln Arg Leu Asp
65 70 75 80

Thr His Gly Gly Trp Ala Leu Tyr Val Asp Gly Asp Pro Asp Val Ser
85 90 95

Cys Ser Val Lys Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu
100 105 110

His Ala Pro His Met Val Arg Ala Arg Asp Ala Ile Leu Lys Leu Gly
115 120 125

Gly Ala Ala Arg Ala Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe
130 135 140

Gly Gln Val Pro Trp Arg Ala Ala Pro Phe Met Pro Ile Glu Phe Val
145 150 155 160

Leu Phe Pro Lys Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp
165 170 175

Ala Arg Thr Thr Met Val Pro Leu Leu Val Leu Cys Ser Leu Lys Ala
180 185 190

Arg Ala Arg Asn Pro Arg Asn Ile Ser Ile Arg Glu Leu Phe Val Thr
195 200 205

Pro Pro Asp Glu Glu Arg Gln Tyr Phe Pro Pro Ala Arg Gly Met Arg
210 215 220

Lys Leu Phe Leu Ala Leu Asp Arg Thr Val Arg His Val Glu Pro Leu
225 230 235 240

Met Pro Lys Gly Leu Arg Gln Arg Ala Ile Arg His Ala Glu Ala Trp
245 250 255

Cys Ala Glu Arg Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro
260 265 270

Pro Ile Val Tyr Cys Tyr Gln Met Met Glu Val Leu Gly Tyr Pro Asp
275 280 285

Asp His Pro Leu Arg Arg Asp Cys Glu Asn Ala Leu Glu Lys Leu Leu
290 295 300

Val Thr Arg Pro Asp Gly Ser Met Tyr Cys Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Gly
325 330 335

Val Ala Val Ala Glu Asp Gly Glu Pro Gly Asp Ala Arg Arg Ala Leu
340 345 350

Asp Glu Arg Ile Thr Arg Ala Tyr Asp Trp Leu Ala Glu Arg Gln Val
355 360 365

Asn Asp Leu Arg Gly Asp Trp Ile Glu Asn Ala Pro Ala Asp Val Gln
370 375 380

Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp Ile
385 390 395 400

Asp Asp Thr Ala Val Val Thr Ala Met Leu Asp Arg Arg Gly Arg Thr
405 410 415

His Ala Asn Ala Asp Gly Thr Asn Pro Tyr Ala Thr Arg Val Ala Arg
420 425 430

Ala Leu Asp Trp Met Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe Gly
435 440 445

Ala Phe Asp Ala Asp Cys Asp Arg Leu Tyr Leu Asn Ala Ile Pro Phe
450 455 460

Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly
465 470 475 480

Arg Val Leu Leu Cys Phe Gly Val Thr Lys Arg Ala Asp Glu His Ala
485 490 495

Ser Leu Ala Arg Cys Ile Asp Tyr Val Lys Arg Thr Gln Gln Pro Asp
500 505 510

Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp
515 520 525

Ser Val Leu Ala Gly Leu Ala Leu Ala Gly Glu Asp Lys Ser Gln Pro
530 535 540

Tyr Ile Ala Arg Ala Ile Glu Trp Leu Arg Ala Arg Gln His Ala Asp
545 550 555 560

Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Ile Asp Pro Lys Leu Gly
565 570 575

Gly Thr Asn Gly Gly Glu Ser Thr Ser Asn Phe Thr Ala Trp Ala Leu
580 585 590

Leu Ala Gln Met Ala Phe Gly Asp Cys Glu Ser Asp Ser Val Lys Arg
595 600 605

Gly Ile Ala Tyr Leu Gln Ser Val Gln Gln Glu Asp Gly Phe Trp Trp
610 615 620

His Arg Ser His Asn Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu Lys
625 630 635 640

Tyr His Gly Tyr Thr Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr
645 650 655

Arg Arg Leu Ala Gly Val Ala Asn Lys Arg Val Ser Thr Ala Asp Lys
660 665 670

Thr Ala Asp Ala Met Ala
675


<210> 101
<211> 657
<212> PRT
<213> Burkholderia sp.

<400> 101
Met Asn Asp Leu Thr Glu Met Ala Thr Leu Ser Ala Gly Ala Val Pro
1 5 10 15

Ala Gly Val Asp Thr Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Asn Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu Thr
50 55 60

Pro Asn Leu Glu Leu Glu Gln Lys Ile Gly Lys Tyr Leu Arg Arg Ile
65 70 75 80

Gln Gln Ala Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Tyr Gly Ala Ile Pro Trp Arg Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Leu Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe
195 200 205

Ile Asp Pro Pro Val Asn Ala Gly Leu Leu Pro Arg Gln Gly His Gln
210 215 220

Ser Ala Gly Trp Phe Ala Phe Phe Arg Val Val Asp His Ala Leu Arg
225 230 235 240

Ala Val Asp Gly Leu Phe Pro Asn Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ser Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ser Val Met Met Tyr Asp Val
275 280 285

Leu Gly Tyr Ala Glu Asp His Pro Asn Arg Ala Ile Ala Arg Lys Ser
290 295 300

Ile Glu Lys Leu Leu Val Val Gln Glu Asp Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala Asn Ala Leu Leu
325 330 335

Glu Thr Arg Asp Ala Arg Ala Glu Asp Ala Ala Ile Arg Gly Leu Glu
340 345 350

Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro His Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Val Ala Met
385 390 395 400

Glu Arg Ala Gln Gln Leu Lys Gln Asn Asp Ala Tyr Arg Asp Ser Ile
405 410 415

Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ser Gln Leu Gly Glu Thr Pro Leu
465 470 475 480

Asn Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Val Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly Leu Thr Pro
515 520 525

Asp Asp Pro Arg Val Lys Arg Gly Ala Gln Trp Leu Leu Ser Ile Gln
530 535 540

Asn Lys Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asn
545 550 555 560

Tyr Arg Gly Phe Glu Gln Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asn Asn Pro Ala Val
580 585 590

Ala Arg Gly Ile Asp Tyr Leu Ile Ala Glu Gln Asn Ala Glu Gly Leu
595 600 605

Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Asp Asn Thr Thr Arg Val Thr Val Gly
645 650 655

Leu


<210> 102
<211> 694
<212> PRT
<213> Burkholderia sp. CCGE1002

<400> 102
Met Asn Asp Leu Ser Gln Thr Gln Pro Leu Asp Ala Val Leu Pro Glu
1 5 10 15

Ala Ala Asp Ala Ala Ser Asn Leu Ala Glu Ala Ala Val Val Ala Asn
20 25 30

Ala Pro Ala Val Ala Asp Ala Leu Ala Thr Ala Thr Pro Ser Pro Met
35 40 45

Gln Thr Ala Gly Ala Ser Pro Leu Asp Val Ser Ile Thr Arg Ala Thr
50 55 60

Asp Ala Ile Leu Ala Ala Gln Gln Pro Asp Gly His Trp Ile Tyr Glu
65 70 75 80

Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His
85 90 95

Tyr Leu Gly Glu Thr Pro Asn Leu Glu Leu Glu Gln Lys Ile Ala Arg
100 105 110

Tyr Leu Arg Arg Ile Gln Leu Pro Asn Gly Gly Trp Pro Leu Phe Thr
115 120 125

Asp Gly Ala Leu Asp Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu
130 135 140

Lys Met Ile Gly Asp Pro Val Asp Ala Glu His Met Val Arg Ala Arg
145 150 155 160

Asp Ala Ile Leu Ala His Gly Gly Ala Glu His Ala Asn Val Phe Thr
165 170 175

Arg Ile Leu Leu Ala Leu Phe Gly Val Val Ser Trp Arg Ala Val Pro
180 185 190

Met Met Pro Val Glu Ile Met Leu Leu Pro Met Trp Phe Pro Phe His
195 200 205

Leu Ser Lys Val Ser Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu
210 215 220

Val Leu Asn Ala Lys Arg Pro Leu Ala Arg Asn Pro Arg Lys Val Arg
225 230 235 240

Ile Asp Glu Leu Phe Arg Gly Ala Pro Val Asn Thr Gly Met Asn Glu
245 250 255

Arg Ala Pro His Gln His Ala Gly Trp Phe Gly Phe Phe Arg Cys Val
260 265 270

Asp Thr Val Leu Arg Ala Val Asp Gly Leu Leu Pro Lys Ala Ser Arg
275 280 285

Glu Arg Ala Ile Arg Ala Ala Val Ala Phe Val Asp Glu Arg Leu Asn
290 295 300

Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Ala Asn Ser Val
305 310 315 320

Met Met Tyr Asp Val Leu Gly Tyr Pro Ala Asp His Pro Asn Arg Ala
325 330 335

Ile Ala Arg Lys Ser Leu Asp Lys Leu Leu Val Ile Lys Glu Asp Glu
340 345 350

Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Val
355 360 365

Ala His Ala Leu Leu Glu Thr Arg Glu Ala Arg Ala Glu Gln Ala Ala
370 375 380

Glu Arg Gly Leu Ala Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg
385 390 395 400

Gly Asp Trp Ile Ser Arg Arg Pro Asn Val Arg Pro Gly Gly Trp Ala
405 410 415

Phe Gln Tyr Asn Asn Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val
420 425 430

Val Ala Met Ala Met His Arg Ser Ala Ala Leu Thr Lys Ser Asp Val
435 440 445

Asp Arg Glu Ala Ile Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln
450 455 460

Ser Ser Glu Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr
465 470 475 480

Tyr Leu Asn Asn Ile Pro Phe Ser Asp His Ala Ala Leu Leu Asp Pro
485 490 495

Pro Thr Ala Asp Val Ser Gly Arg Cys Leu Ser Met Phe Ala Gln Ile
500 505 510

Gly Glu Leu Pro Gln Asn Ser Glu Pro Ala Gln Arg Ala Phe Asp Tyr
515 520 525

Met Leu Gln Glu Gln Glu Ser Asp Gly Ser Trp Tyr Gly Arg Trp Gly
530 535 540

Leu Asn Tyr Ile Tyr Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala
545 550 555 560

Ala Gly Met Ser His Asp Asp Pro Arg Met Arg Arg Ala Val Gln Trp
565 570 575

Leu Val Ser Ile Gln Asn Glu Asp Gly Gly Trp Gly Glu Gly Gly Glu
580 585 590

Ser Tyr Lys Leu Asp Tyr Arg Gly Tyr Glu Arg Ala Pro Ser Thr Ala
595 600 605

Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val
610 615 620

Asp His Asp Ala Val Ala Arg Gly Ile Asp Tyr Leu Gln Arg Glu Gln
625 630 635 640

Arg Glu His Gly Leu Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe
645 650 655

Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro
660 665 670

Leu Trp Ala Leu Ala Arg Phe Arg His Leu Lys Arg Asn Gly Leu Thr
675 680 685

Arg Val Thr Val Gly Met
690


<210> 103
<211> 672
<212> PRT
<213> Burkholderia thailandensis

<400> 103
Met Asn Asp Met Thr Glu Met His Thr Leu Asp Ala Thr Ala Val Pro
1 5 10 15

Ala Ala Pro Ala Ala Ala Asp Ala Pro Ala Pro Ser Ala Ala Thr Thr
20 25 30

Gly Leu Asp Ala Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala Ala
35 40 45

Gln Asn Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser Thr
50 55 60

Ile Pro Ala Glu Tyr Val Leu Leu Val His Tyr Leu Gly Glu Glu Pro
65 70 75 80

Asn Ala Glu Leu Glu Gln Lys Ile Ala Arg Tyr Leu Arg Arg Ile Gln
85 90 95

Gln Pro Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn Ile
100 105 110

Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp Asp
115 120 125

Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala Met
130 135 140

Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala Leu
145 150 155 160

Tyr Gly Val Val Pro Trp Tyr Ala Val Pro Met Met Pro Val Glu Ile
165 170 175

Ile Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser Tyr
180 185 190

Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys Arg
195 200 205

Pro Val Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe Lys
210 215 220

Ser Ala Pro Val Asn Thr Gly Leu Leu Pro Lys Gln Pro His Gln His
225 230 235 240

Ala Gly Trp Phe Ala Phe Phe Arg Ala Val Asp Gly Val Leu Arg Leu
245 250 255

Ala Asp Gly Leu Phe Pro Arg Tyr Thr Arg Glu Arg Ala Ile Arg Gln
260 265 270

Ala Ala Ala Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly
275 280 285

Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Ala Ala Leu
290 295 300

Gly Tyr Pro Glu Asp His Pro Asn Arg Ala Ile Ala Arg Gln Ser Ile
305 310 315 320

Glu Lys Leu Leu Val Val Gly Glu Glu Glu Ala Tyr Cys Gln Pro Cys
325 330 335

Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu Glu
340 345 350

Thr Gly Asp Glu Arg Ala Arg Glu Ala Ala Val Arg Gly Leu Asp Trp
355 360 365

Leu Val Pro Arg Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser Arg
370 375 380

Arg Pro His Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Ala
385 390 395 400

His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Met Ala Met Asp
405 410 415

Arg Val Ala Lys His Asp Gln Thr Asp Ala Tyr Arg Glu Ser Ile Ala
420 425 430

Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly Trp
435 440 445

Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile Pro
450 455 460

Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser
465 470 475 480

Gly Arg Cys Leu Ser Met Leu Ala Gln Leu Gly Glu Thr Ser Ala Ser
485 490 495

Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln Glu
500 505 510

Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Ile Tyr Gly
515 520 525

Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly Leu Gly His Asp
530 535 540

Asp Pro Arg Val Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln Asn
545 550 555 560

Pro Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asp Tyr
565 570 575

Arg Gly Tyr Glu Arg Ala Pro Ser Thr Ser Ser Gln Thr Ala Trp Ala
580 585 590

Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asp Asn Pro Ala Val Ala
595 600 605

Arg Gly Ile Gly His Leu Leu Gly Thr Gln Arg Glu His Gly Leu Trp
610 615 620

Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu
625 630 635 640

Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg
645 650 655

Tyr Arg Asn Leu Lys Arg Ala Gly Ala Ala Arg Val Thr Val Gly Met
660 665 670




<210> 104
<211> 663
<212> PRT
<213> Burkholderia thailandensis

<400> 104
Met Asn Asp Met Thr Glu Met His Thr Leu Asp Ala Thr Ala Ala Pro
1 5 10 15

Ala Ala Pro Thr Val Ala Thr Gly Leu Asp Ala Ala Val Ala Arg Ala
20 25 30

Thr Asp Ala Leu Leu Ala Ala Gln Asn Ala Asp Gly His Trp Val Tyr
35 40 45

Glu Leu Glu Ala Asp Ser Thr Ile Pro Ala Glu Tyr Val Leu Leu Val
50 55 60

His Tyr Leu Gly Glu Ala Pro Asn Val Glu Leu Glu Arg Lys Ile Ala
65 70 75 80

Arg Tyr Leu Arg Arg Ile Gln Leu Pro Asp Gly Gly Trp Pro Leu Phe
85 90 95

Thr Asp Gly Ala Pro Asn Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala
100 105 110

Leu Lys Val Ile Gly Asp Asp Glu Asn Ala Glu His Met Gln Arg Ala
115 120 125

Arg Arg Ala Ile His Ala Met Gly Gly Ala Glu Met Ser Asn Val Phe
130 135 140

Thr Arg Ile Gln Leu Ala Leu Tyr Gly Val Val Pro Trp Tyr Ala Val
145 150 155 160

Pro Met Met Pro Val Glu Ile Met Leu Leu Pro Gln Trp Phe Pro Phe
165 170 175

His Leu Ser Lys Val Ser Tyr Trp Ala Arg Thr Val Ile Val Pro Leu
180 185 190

Leu Val Leu Asn Ala Lys Arg Pro Val Ala Lys Asn Pro Arg Gly Val
195 200 205

Arg Ile Asp Glu Leu Phe Lys Ser Ala Pro Val Asn Thr Gly Leu Leu
210 215 220

Pro Lys Gln Pro His Gln Ser Ala Gly Trp Phe Ala Phe Phe Arg Ala
225 230 235 240

Val Asp Gly Val Leu Arg Leu Thr Asp Gly Leu Phe Pro Arg Tyr Thr
245 250 255

Arg Glu Arg Ala Ile Arg Gln Ala Val Ala Phe Val Asp Glu Arg Leu
260 265 270

Asn Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala
275 280 285

Val Met Met Tyr Ala Ala Leu Gly Tyr Pro Glu Asp His Pro Asn Arg
290 295 300

Ala Ile Ala Arg Gln Ser Ile Glu Lys Leu Leu Val Val Gly Glu Asp
305 310 315 320

Glu Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ser Leu
325 330 335

Ala Ala His Ala Leu Leu Glu Thr Gly Asp Glu Arg Ala Arg Glu Ala
340 345 350

Ala Val Arg Gly Leu Asp Trp Leu Val Pro Arg Gln Ile Leu Asp Val
355 360 365

Arg Gly Asp Trp Ile Ser Arg Arg Pro His Val Arg Pro Gly Gly Trp
370 375 380

Ala Phe Gln Tyr Ala Asn Ala His Tyr Pro Asp Val Asp Asp Thr Ala
385 390 395 400

Val Val Ala Met Ala Met Asp Arg Val Ala Lys Leu Asp Arg Thr Asp
405 410 415

Ala Tyr Arg Glu Ser Ile Ala Arg Ala Arg Glu Trp Val Val Gly Met
420 425 430

Gln Ser Ser Asp Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln
435 440 445

Tyr Tyr Leu Asn Asn Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp
450 455 460

Pro Pro Thr Ala Asp Val Ser Gly Arg Cys Leu Ser Met Leu Ala Gln
465 470 475 480

Phe Gly Glu Thr Ser Ala Ser Ser Glu Pro Ala Arg Arg Ala Leu Asp
485 490 495

Tyr Met Leu Lys Glu Gln Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp
500 505 510

Gly Met Asn Tyr Ile Tyr Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn
515 520 525

Ala Ala Gly Leu Gly His Asp Asp Pro Arg Val Lys Arg Ala Ala Gln
530 535 540

Trp Leu Leu Ser Ile Gln Asn Pro Asp Gly Gly Trp Gly Glu Asp Gly
545 550 555 560

Asp Ser Tyr Lys Leu Asp Tyr Arg Gly Tyr Glu Arg Ala Pro Ser Thr
565 570 575

Ser Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala Gly Glu
580 585 590

Val Asp His Pro Ala Val Ala Arg Gly Ile Asp His Leu Leu Gly Thr
595 600 605

Gln Arg Glu His Gly Leu Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly
610 615 620

Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe
625 630 635 640

Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu Lys Arg Ala Asn Ala
645 650 655

Thr Arg Val Thr Val Gly Met
660


<210> 105
<211> 678
<212> PRT
<213> Burkholderia ubonensis

<400> 105
Met Lys Pro Asn His Thr Phe Ser Pro Ala Ala Leu Asp Ala Ala Ile
1 5 10 15

Leu Arg Gly Arg Asp Thr Leu Ser Gly Leu Gln Gln Pro Asp Gly Ser
20 25 30

Trp Cys Phe Glu Leu Glu Ser Asp Ala Thr Ile Thr Ala Glu Tyr Ile
35 40 45

Leu Met Met His Phe Met Asp Lys Ile Asp Glu Val Arg Gln Ala Gln
50 55 60

Met Ala Arg Tyr Leu Arg Ala Ile Gln Arg Val Glu Thr His Gly Ala
65 70 75 80

Trp Asp Leu Tyr Val Asp Gly Ala Pro Asp Ile Ser Cys Ser Val Lys
85 90 95

Ala Tyr Phe Ala Leu Lys Ala Ala Gly Asp Ser Glu His Ala Pro His
100 105 110

Met Ile Arg Ala Arg Glu Ala Ile Leu Lys Leu Gly Gly Ala Ala Arg
115 120 125

Ser Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe Gly Gln Val Pro
130 135 140

Trp Arg Ala Ala Pro Phe Met Pro Val Glu Phe Val Leu Phe Pro Lys
145 150 155 160

Trp Val Pro Ile Ser Met Tyr Lys Val Ala Tyr Trp Ala Arg Thr Thr
165 170 175

Met Val Pro Leu Leu Val Leu Cys Ser Leu Arg Ala Arg Ala Arg Asn
180 185 190

Pro Arg Asn Val Ser Ile Ala Glu Leu Phe Val Thr Pro Pro Asp Glu
195 200 205

Glu Arg His Tyr Phe Pro Pro Ala Lys Gly Met Arg Lys Leu Phe Leu
210 215 220

Ala Leu Asp Arg Thr Val Arg His Leu Glu Pro Leu Leu Pro Arg Arg
225 230 235 240

Leu Arg Gln Arg Ala Ile Arg His Ala Glu Ala Trp Cys Ala Glu Arg
245 250 255

Met Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro Pro Ile Val Tyr
260 265 270

Ser Tyr Gln Met Met Glu Val Leu Gly Tyr Pro Glu Asp His Pro Leu
275 280 285

Arg Arg Asp Cys Glu Asp Ala Leu Glu Lys Leu Leu Val Thr Arg Ala
290 295 300

Asp Gly Ser Val Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr
305 310 315 320

Ala Trp Ser Thr Met Ala Leu Glu Gln Ala Arg Gly Ala Thr Pro Ala
325 330 335

Ala Pro Asp Thr Gln Val Ser Glu Arg Glu Leu Asp Ala Arg Ile Ala
340 345 350

Arg Ala Tyr Asp Trp Leu Ala Thr Arg Gln Val Asn Asp Leu Glu Gly
355 360 365

Asp Trp Arg Glu Asn Ala Arg Pro Gly Thr Leu Pro Gly Gly Trp Ala
370 375 380

Phe Gln Tyr Ala Asn Pro Tyr Tyr Pro Asp Ile Asp Asp Ser Ala Val
385 390 395 400

Val Thr Ala Met Leu Asp Arg Arg Gly Arg Ala Gln Ala Arg Ala Ser
405 410 415

Gly Glu Asn Pro Tyr Ala Glu Arg Val Thr Arg Ala Leu Asp Trp Met
420 425 430

Arg Gly Leu Gln Ser Arg Asn Gly Gly Phe Gly Ala Phe Asp Ala Asp
435 440 445

Cys Asp Arg Leu Tyr Leu Asn Ala Ile Pro Phe Ala Asp His Gly Ala
450 455 460

Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly Arg Val Leu Leu Cys
465 470 475 480

Phe Gly Val Thr Lys Arg Pro Ala Asp Arg Ala Ala Ala Ala Arg Ala
485 490 495

Ile Glu Tyr Val Lys Arg Thr Gln Gln Pro Asp Gly Ser Trp Trp Gly
500 505 510

Arg Trp Gly Thr Asn Tyr Leu Tyr Gly Thr Trp Ser Val Leu Ala Gly
515 520 525

Leu Ala Leu Ser Gly Glu Asp Lys Ser Gln Pro Tyr Ile Ala Arg Ala
530 535 540

Leu Asp Trp Leu Arg Ala His Gln His Ala Asp Gly Gly Trp Gly Glu
545 550 555 560

Thr Asn Asp Ser Tyr Ala Asp Pro Arg Leu Arg Ala Thr Asn Tyr Gly
565 570 575

Glu Ser Thr Ser Asn Cys Thr Ala Trp Ala Leu Leu Ala Gln Met Ala
580 585 590

Phe Gly Asp Trp Gln Ser Asp Ser Val Arg Arg Gly Ile Ala Tyr Leu
595 600 605

Leu Ser Val Gln Gln Asp Asp Gly Phe Trp Trp His Arg Ser His Asn
610 615 620

Ala Pro Gly Phe Pro Arg Ile Phe Tyr Leu Lys Tyr His Gly Tyr Thr
625 630 635 640

Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Arg Leu Ala Gly
645 650 655

Ala Gln Ala Ala Pro Ser Ser Pro Gly Pro Gly Thr Ala Ala Thr Ile
660 665 670

Ala Asp Pro Ala Val Ala
675


<210> 106
<211> 657
<212> PRT
<213> Burkholderia ubonensis

<400> 106
Met Asn Asp Leu Thr Asp Met Pro Thr Leu Ala Ala Asp Ser Ala Ala
1 5 10 15

Ala Asp Leu Asp Ala Ala Val Ala Arg Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Gln Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Ile Leu Leu Val His Tyr Leu Gly Glu Thr
50 55 60

Pro Asn Leu Glu Leu Glu Gln Lys Ile Gly Arg Tyr Leu Arg Arg Ile
65 70 75 80

Gln Gln Pro Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Tyr Gly Ala Ile Pro Trp Arg Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Ile Ala Lys Asn Pro Arg Gly Val Arg Ile Asp Glu Leu Phe
195 200 205

Ile Asp Pro Pro Val Asn Ala Gly Leu Leu Pro Arg Gln Gly His Gln
210 215 220

Ser Ala Gly Trp Phe Ala Phe Phe Arg Val Val Asp His Ala Leu Arg
225 230 235 240

Ala Val Asp Gly Leu Phe Pro Ser Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ala Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Asp Ala
275 280 285

Leu Gly Tyr Pro Glu Asp His Pro Asn Arg Ala Ile Ala Arg Arg Ser
290 295 300

Val Glu Lys Leu Leu Val Val His Asp Asp Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu
325 330 335

Glu Thr Gly Asp Pro Arg Ala Glu Asp Ala Val Val Arg Gly Leu Glu
340 345 350

Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro Asn Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Pro His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Met Ala Met
385 390 395 400

Asp Arg Val Glu Lys Leu Arg His Ser Asp Ala Tyr Arg Glu Ala Ile
405 410 415

Ser Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ser Gln Leu Gly Glu Thr Ala Ala
465 470 475 480

Asn Ser Glu Ala Ala Arg Arg Ser Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Val Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly Leu Gly Pro
515 520 525

Asp Asp Pro Arg Val Lys Arg Gly Ala Gln Trp Leu Leu Ser Val Gln
530 535 540

Asn Lys Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asp
545 550 555 560

Tyr Arg Gly Tyr Glu Gln Ala Pro Ser Thr Ser Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asn His Pro Ala Val
580 585 590

Ala Arg Gly Ile Asp Tyr Leu Ile Ala Glu Gln Lys Glu His Gly Leu
595 600 605

Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Ala Asn Ala Thr Arg Val Thr Val Gly
645 650 655

Met


<210> 107
<211> 657
<212> PRT
<213> Burkholderia vietnamiensis

<400> 107
Met Asn Asp Leu Thr Asp Met Ala Asn Leu Ser Ala Gly Thr Val Pro
1 5 10 15

Ala Gly Leu Asp Ala Ser Val Ala Arg Ala Thr Asp Ala Leu Leu Ala
20 25 30

Ala Gln Asn Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ser
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His Phe Leu Gly Glu Thr
50 55 60

Pro Asn Leu Glu Leu Glu Gln Lys Ile Gly Arg Tyr Leu Arg Arg Ile
65 70 75 80

Gln Gln Ala Asp Gly Gly Trp Pro Leu Phe Thr Asp Gly Ala Pro Asn
85 90 95

Val Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Val Ile Gly Asp
100 105 110

Asp Glu Asn Ala Glu His Met Gln Arg Ala Arg Arg Ala Ile His Ala
115 120 125

Met Gly Gly Ala Glu Met Ser Asn Val Phe Thr Arg Ile Gln Leu Ala
130 135 140

Leu Phe Gly Ala Ile Pro Trp Arg Ala Val Pro Met Met Pro Val Glu
145 150 155 160

Ile Met Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser
165 170 175

Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ala Lys
180 185 190

Arg Pro Leu Ala Lys Asn Pro Arg Gly Val Arg Ile Gly Glu Leu Phe
195 200 205

Ile Asp Pro Pro Val Asn Ala Gly Leu Leu Pro Arg Gln Gly His Gln
210 215 220

Ser Pro Gly Trp Phe Ala Phe Phe Arg Val Val Asp His Ala Leu Arg
225 230 235 240

Ala Ala Asp Gly Leu Phe Pro Ser Tyr Thr Arg Glu Arg Ala Ile Arg
245 250 255

Gln Ala Val Ser Phe Val Asp Glu Arg Leu Asn Gly Glu Asp Gly Leu
260 265 270

Gly Ala Ile Tyr Pro Ala Met Ala Asn Ala Val Met Met Tyr Asp Val
275 280 285

Leu Gly Tyr Pro Glu Asp His Pro Asn Arg Ala Ile Ala Arg Lys Ser
290 295 300

Ile Glu Lys Leu Leu Val Val His Asp Asp Glu Ala Tyr Cys Gln Pro
305 310 315 320

Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Val Ala His Ala Leu Leu
325 330 335

Glu Thr Gly Asp Ala Arg Ala Glu Gln Ala Val Leu Arg Gly Leu Asp
340 345 350

Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg Gly Asp Trp Ile Ser
355 360 365

Arg Arg Pro Asn Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn
370 375 380

Ala His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Met Ala Met
385 390 395 400

Asp Arg Ala Gln Lys Leu Gln Asn Thr Asp Thr Tyr Arg Glu Ser Ile
405 410 415

Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln Ser Ser Asp Gly Gly
420 425 430

Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr Tyr Leu Asn Asn Ile
435 440 445

Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
450 455 460

Ser Gly Arg Cys Leu Ser Met Leu Ala Gln Leu Gly Glu Ser Ala Leu
465 470 475 480

Ser Ser Glu Pro Ala Arg Arg Ala Leu Asp Tyr Met Leu Lys Glu Gln
485 490 495

Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Val Tyr
500 505 510

Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala Ala Gly Leu Gly Pro
515 520 525

Glu Asp Pro Arg Val Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln
530 535 540

Asn Lys Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Asn
545 550 555 560

Tyr Arg Gly Phe Glu Pro Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp
565 570 575

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Val Asn His Pro Ala Val
580 585 590

Glu Arg Gly Ile Gly Tyr Leu Ile Ala Gln Gln Asn Asp Glu Gly Leu
595 600 605

Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr
610 615 620

Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro Leu Trp Ala Leu Ala
625 630 635 640

Arg Tyr Arg Asn Leu Lys Arg Ala Asn Ala Thr Arg Val Thr Val Gly
645 650 655

Ile


<210> 108
<211> 678
<212> PRT
<213> Burkholderia xenovorans

<400> 108
Met Asn Asp Leu Ser Gln Thr Gln Pro Arg Asp Ala Val Leu Pro Glu
1 5 10 15

Ala Ala Gly Ala Val Pro Pro Ala Ser Ala Pro Ala Pro Ala Ala Ala
20 25 30

Ser Glu Ala Pro Ala Ala Ser Leu Asp Thr Ala Ile Thr Arg Ala Thr
35 40 45

Asp Ala Ile Leu Ala Ala Gln Lys Pro Asp Gly His Trp Val Tyr Glu
50 55 60

Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu Leu Val His
65 70 75 80

Tyr Leu Gly Glu Thr Pro Asn Val Glu Leu Glu Gln Lys Ile Ala Arg
85 90 95

Tyr Leu Arg Arg Ile Gln Leu Pro Asp Gly Gly Trp Pro Leu Phe Thr
100 105 110

Asp Gly Ala Pro Asp Val Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu
115 120 125

Lys Met Ile Gly Asp Pro Ala Asp Ala Glu His Met Val Arg Ala Arg
130 135 140

Glu Ala Ile Leu Ala Asn Gly Gly Ala Glu Ala Val Asn Val Phe Thr
145 150 155 160

Arg Ile Leu Leu Ala Leu Phe Gly Val Val Ser Trp Arg Ala Val Pro
165 170 175

Met Met Pro Val Glu Ile Met Leu Leu Pro Met Trp Phe Pro Phe His
180 185 190

Leu Ser Lys Val Ser Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu
195 200 205

Val Leu Asn Ala Lys Arg Pro Leu Ala Arg Asn Pro Arg Arg Val Arg
210 215 220

Ile Asp Glu Leu Phe Arg Gly Ala Pro Val Asn Thr Gly Pro Arg Asp
225 230 235 240

Arg Ala Pro His Gln His Ala Gly Trp Phe Arg Phe Phe Ser Gly Val
245 250 255

Asp Met Leu Leu Arg Ala Val Asp Gly Leu Phe Pro Lys Ala Thr Arg
260 265 270

Glu Arg Ala Val Arg Ala Ala Val Ala Phe Val Asp Glu Arg Leu Asn
275 280 285

Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Ala Asn Ser Val
290 295 300

Met Met Tyr Asp Val Leu Gly Tyr Pro Ala Asp His Pro Asn Arg Ala
305 310 315 320

Ile Ala Arg Gln Ser Ile Glu Lys Leu Leu Val Ile Lys Asp Asp Glu
325 330 335

Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ser Leu Val
340 345 350

Ala His Ala Leu Leu Glu Thr Gly Glu Ala Arg Ala Glu Gln Ala Ala
355 360 365

Glu Arg Gly Leu Ala Trp Leu Arg Pro Leu Gln Ile Leu Asp Val Arg
370 375 380

Gly Asp Trp Ile Ser Arg Arg Pro Asn Val Arg Pro Gly Gly Trp Ala
385 390 395 400

Phe Gln Tyr Asn Asn Asp Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val
405 410 415

Val Val Met Ala Met His Arg Ser Ala Ala Leu Thr His Ser Glu Val
420 425 430

Asp Arg Glu Ala Ile Ala Arg Ala Arg Glu Trp Val Val Gly Met Gln
435 440 445

Ser Ser Asp Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr Gln Tyr
450 455 460

Tyr Leu Asn Asn Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp Pro
465 470 475 480

Pro Thr Ala Asp Val Ser Gly Arg Cys Leu Ser Met Leu Ala Gln Leu
485 490 495

Gly Glu Leu Pro Gln Gly Ser Glu Pro Ala Gln Arg Ala Phe Ala Tyr
500 505 510

Met Leu Lys Glu Gln Glu Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly
515 520 525

Leu Asn Tyr Ile Tyr Gly Thr Trp Thr Ala Leu Cys Ser Leu Asn Ala
530 535 540

Ala Gly Met Pro His Asp Asp Pro Arg Met Lys Arg Ala Ala Lys Trp
545 550 555 560

Leu Leu Ser Ile Gln Asn Glu Asp Gly Gly Trp Gly Glu Gly Gly Glu
565 570 575

Ser Tyr Lys Leu Asp Tyr His Gly Tyr Glu Arg Ala Pro Ser Thr Ala
580 585 590

Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Met Ala Ala Gly Glu Val
595 600 605

Asn His Glu Ala Val Ala Arg Gly Val Ala Tyr Leu Gln Arg Glu Gln
610 615 620

Arg Glu His Gly Leu Trp Asp Glu Thr Arg Phe Thr Ala Thr Gly Phe
625 630 635 640

Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Lys Phe Phe Pro
645 650 655

Leu Trp Ala Leu Ala Arg Phe Arg His Leu Lys Arg His Gly Leu Thr
660 665 670

Arg Val Ala Val Gly Met
675


<210> 109
<211> 657
<212> PRT
<213> Candidatus Koribacter

<400> 109
Met Asp Asp Arg His Ile Gln Ser Glu Ile Thr Phe Gly Lys Ile Asp
1 5 10 15

Gly Ile Arg Glu Arg Ile Gln Gln Ala Met Asp Ala Ala Lys Arg Tyr
20 25 30

Leu Phe Ser Lys Gln Asp Pro Glu Gly Phe Trp Cys Gly Glu Leu Glu
35 40 45

Ala Asp Thr Thr Leu Gln Ser Asp Tyr Ile Val Met His Thr Leu Leu
50 55 60

Gly Thr Gly Asp Pro Val Lys Met Gln Lys Ala Gly Lys Gln Ile Leu
65 70 75 80

Gln His Gln Asn Pro Asp Gly Gly Trp Asn Ile Tyr Pro Asp Gly Pro
85 90 95

Ser Asn Ile Ser Ala Ala Val Lys Ala Tyr Phe Ser Leu Lys Leu Ile
100 105 110

Gly His Lys Pro Asp Glu Pro Glu Met Thr Lys Ala Arg Glu Trp Ile
115 120 125

Leu Ala His Gly Gly Val Thr Ala Cys Asn Thr Phe Ser Lys Met Tyr
130 135 140

Leu Cys Phe Phe Gly Gln Tyr Asp Tyr Asp Thr Val Pro Ala Ile Pro
145 150 155 160

Pro Glu Ile Val Leu Phe Pro Asn Trp Phe Trp Phe Asn Leu Tyr Glu
165 170 175

Ile Ser Ser Trp Ser Arg Gly Ile Leu Val Pro Leu Ala Ile Cys Tyr
180 185 190

Ala Lys Lys Pro Phe Lys Lys Ile Pro Asp Glu Ala Asn Ile Asp Glu
195 200 205

Leu Phe Val Glu Gly Arg His Ala Asn Leu His Leu Thr Trp Asp Lys
210 215 220

Lys Pro Phe Ser Trp Arg Asn Phe Phe Leu Val Leu Asn Asn Met Val
225 230 235 240

His Phe Phe Glu Arg Val His Val Arg Pro Leu Arg Lys Leu Ala Met
245 250 255

Lys Arg Ala Glu Lys Trp Met Leu Glu Arg Leu Glu Met Ser Asp Gly
260 265 270

Leu Gly Gly Ile Tyr Pro Ala Ile Leu Asn Ser Ile Ile Ala Leu Arg
275 280 285

Ala Leu Gly Tyr Ser Thr Asp Asp Pro Gln Val Ile Arg Ala Met Asp
290 295 300

Glu Phe Glu Lys Leu Gly Ile Glu Glu Asp Asp Thr Phe Arg Met Gln
305 310 315 320

Pro Cys Met Ser Pro Val Trp Asp Thr Ala Tyr Ala Leu Tyr Ala Leu
325 330 335

Gly Glu Ala Gly Val Pro Gly Ser Asp Pro Arg Met Gln Lys Ala Ala
340 345 350

Glu Trp Met Leu Lys Lys Gln Val Thr His Lys Gly Asp Trp Ala Val
355 360 365

Lys Val Arg Asn Val Gln Pro Gly Gly Trp Tyr Phe Glu Phe Asn Asn
370 375 380

Glu Phe Tyr Pro Asp Val Asp Asp Thr Ala Gln Val Ile Leu Ser Leu
385 390 395 400

Asn His Val Arg Thr Ser Asn Glu Arg Tyr Gln Asp Asp Thr Val Lys
405 410 415

Arg Ala Leu Asp Trp Gln Leu Ala Met Gln Cys Lys Asn Gly Gly Trp
420 425 430

Ala Ser Phe Asp Lys Asp Asn Asn Lys Met Val Phe Gln Tyr Ile Pro
435 440 445

Phe Ala Asp His Asn Ala Met Leu Asp Pro Ala Thr Val Asp Ile Thr
450 455 460

Gly Arg Val Leu Glu Ala Leu Ser His His Gly Tyr Ser Leu Lys Asp
465 470 475 480

Lys Val Val Gln Arg Ala Val Lys Phe Ile Gln Ser Glu Gln Glu Pro
485 490 495

Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr
500 505 510

Met Leu Cys Leu Arg Gly Leu Ala Ala Val Gly Val Asp His His Glu
515 520 525

Pro Met Val Gln Gln Ala Ala Glu Trp Leu Arg Met Val Gln Asn Pro
530 535 540

Asp Gly Gly Trp Gly Glu Ser Val Gly Ser Tyr Asp Asp Pro Lys Leu
545 550 555 560

Arg Gly Gln Gly Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Val Met
565 570 575

Gly Leu Leu Ala Ala Asn Asp Leu Arg Ser Asp Ser Val Thr Arg Gly
580 585 590

Ile Ala Trp Leu Leu Glu Asn Gln Lys Pro Asn Gly Ser Trp Trp Glu
595 600 605

Lys Trp Ile Thr Gly Thr Gly Phe Pro Arg Val Phe Tyr Leu Lys Tyr
610 615 620

Thr Met Tyr Ala Glu Tyr Phe Pro Leu Ile Ala Phe Ala Glu Tyr Leu
625 630 635 640

Arg Arg Leu Asn Thr Pro Leu Asp Glu Lys Val Lys Leu Gly Pro Gln
645 650 655

Ala


<210> 110
<211> 488
<212> PRT
<213> Candidatus Kuenenia

<400> 110
Met Ile Leu Phe Pro Ala Gly Phe Tyr Phe Ser Ile Tyr Glu Ile Ser
1 5 10 15

Tyr Trp Ser Arg Cys Ile Val Val Pro Leu Ser Ile Ala Ile Ala Arg
20 25 30

Lys Pro His Val Thr Val Gly Asp Asp Leu Leu Lys Glu Leu Tyr Leu
35 40 45

Val Pro Arg Glu Asp Val Val Tyr Arg Ile Glu Arg Asp Gln Asp Gly
50 55 60

Phe Cys Trp Tyr Asn Phe Phe Ile Asp Ala Asp Ser Ile Phe Arg Arg
65 70 75 80

Tyr Glu Gln His Pro Ile Lys Phe Ile Arg Arg Ile Ala Lys Lys Met
85 90 95

Ala Glu Lys Trp Leu Leu Glu His Met Glu Lys Ser Gly Gly Leu Gly
100 105 110

Ala Ile Trp Pro Ala Met Ile Asn Ser Ile Phe Ala Met Lys Cys Leu
115 120 125

Asp Tyr Pro Asp Asp His Pro Ala Leu Thr Ala Gln Met Lys Glu Val
130 135 140

Glu Ala Leu Val Ile Tyr Glu Gly Asp Met Leu Tyr Leu Gln Pro Cys
145 150 155 160

Val Ser Pro Val Trp Asp Thr Ala Trp Ser Ile Ile Ala Met Asn Asp
165 170 175

Ser Gly Ile Pro Gly Ser His Pro Val Leu Gln Lys Ala Gly Lys Trp
180 185 190

Leu Leu Ser Lys Glu Val Arg Asp Phe Gly Asp Trp Lys Leu Lys Cys
195 200 205

Lys Val Glu Glu Pro Ser Gly Trp Tyr Phe Gln Tyr Ala Asn Glu Phe
210 215 220

Tyr Pro Asp Thr Asp Asp Thr Gly Ala Val Leu Met Ala Leu Gln Arg
225 230 235 240

Val Ser Leu Pro Glu Asp Met His Lys Glu Lys Thr Leu Leu Arg Ala
245 250 255

Leu Arg Trp Leu Gln Ala Met Gln Cys Asp Asp Gly Gly Trp Gly Ala
260 265 270

Phe Asp Arg Asn Asn Asn Lys Thr Ile Leu Asn Asn Ile Pro Phe Ala
275 280 285

Asp Phe Asn Ala Leu Leu Asp Pro Ser Thr Ser Asp Val Thr Gly Arg
290 295 300

Cys Ile Glu Phe Phe Gly Arg Ile Gly Phe Asn Lys Thr Tyr Leu Asn
305 310 315 320

Ile Lys Lys Ala Val Glu Phe Leu Lys Lys Glu Gln Asp Glu Asp Gly
325 330 335

Ser Trp Phe Gly Arg Trp Gly Ser Asn Tyr Ile Tyr Gly Thr Trp Ser
340 345 350

Val Ile Ser Gly Leu Ile Ala Val Gly Glu Asp Ile Asn Lys Ala Tyr
355 360 365

Ile Lys Lys Ala Ile Ala Trp Leu Lys Ser Val Gln Asn Ser Asp Gly
370 375 380

Gly Trp Gly Glu Thr Ile Lys Ser Tyr Glu Asp Ser Ala Leu Lys Gly
385 390 395 400

Ile Gly Lys Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Leu Thr Leu
405 410 415

Ile Thr Ala Gly Glu Ile Lys Ser Ser Ser Thr Glu Arg Gly Ile Asp
420 425 430

Phe Leu Leu Ser Thr Gln Lys Glu Asp Gly Ser Trp Asp Glu Arg Glu
435 440 445

Phe Thr Ala Thr Gly Phe Pro Lys Val Phe Tyr Leu Lys Tyr His Met
450 455 460

Tyr Arg Asn Tyr Phe Pro Leu Met Ala Leu Gly Arg Tyr Arg His Phe
465 470 475 480

Thr His Lys Leu Ala Thr Ser Gln
485


<210> 111
<211> 641
<212> PRT
<213> Candidatus Solibacter

<400> 111
Met Ser Tyr Glu Trp Thr Glu Pro Val Arg Pro Gly Arg Arg His Ala
1 5 10 15

Val Ser Pro Val Gln Asn Phe Cys Gln Ser Leu Ala Pro Ala Ile Gln
20 25 30

Arg Ala Cys Asp Ala Leu Phe Ser Gln Gln Ala Ala Asp Gly Phe Trp
35 40 45

Cys Gly Glu Leu Thr Ala Asp Thr Thr Leu Glu Ser Asp Tyr Ile Leu
50 55 60

Leu Gln Leu Trp Leu Asn Gln Pro Asp Asp His Gly Trp Asn Pro Pro
65 70 75 80

Thr Arg Pro Arg Ile Asp Arg Ala Gly Arg Ser Ile Leu Glu Arg Gln
85 90 95

Leu Pro Asp Gly Gly Phe Asn Ile Tyr Ala Gly Gly Pro Ser Glu Val
100 105 110

Ser Ala Thr Ile Lys Ala Tyr Cys Ala Leu Lys Leu Ala Gly Leu Asp
115 120 125

Pro His Ser Pro Pro Leu Arg Arg Ala Arg Glu Arg Ile Leu Ala Leu
130 135 140

Gly Gly Leu Gln Ala Ala Asn Ser Tyr Val Lys Ile Asn Leu Ser Leu
145 150 155 160

Phe Gly Leu Tyr Pro Arg Lys His Val Pro Ser Val Pro Pro Glu Ile
165 170 175

Val Met Leu Pro Gly Asn Val Leu Tyr Glu Met Ser Ser Trp Thr Arg
180 185 190

Ser Ile Leu Val Pro Leu Ser Ile Val Gln Ala Arg Gly Ser Asn Arg
195 200 205

Arg Ala Pro Asn Gly Phe Asn Leu Asp Glu Leu Leu Leu Pro Gly Val
210 215 220

Lys Leu Ala Leu Pro Lys Arg Lys Gly Leu Ala Val Leu Phe His His
225 230 235 240

Leu Asp Arg Met Phe Lys Val Trp Glu Lys Arg Gly Ser Glu Arg Ile
245 250 255

Arg Gly Ala Ala Ile Arg Glu Ala Glu Arg Trp Leu Ile Ala Arg Thr
260 265 270

His Tyr Thr Glu Gly Leu Gly Ala Ile Tyr Pro Ala Met Met Tyr Phe
275 280 285

Ile Met Ala Leu Asp Ala Leu Gly Tyr Ala Glu Asp His Pro Asp Arg
290 295 300

Ser Glu Ala Ile Arg His Phe Glu Ser Leu Leu Ile Glu Thr Asp Asp
305 310 315 320

Arg Phe Leu Phe Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Ile
325 330 335

Cys Ala Phe Ala Leu Gly Glu Ala Gly Asn Thr Asp Asp Pro Arg Met
340 345 350

Thr Leu Ala Ala Asp Trp Leu Ile Ser Lys Glu Val Arg Arg Lys Gly
355 360 365

Asp Trp Ser Ile Lys Arg Pro Asp Thr Glu Pro Ser Gly Trp Ala Phe
370 375 380

Glu Phe Ala Asn Glu Phe Tyr Pro Asp Ile Asp Asp Thr Ala Met Val
385 390 395 400

Leu Leu Ala Leu Met His Ala Asn Gly Ser Asn Pro Glu Ala Gln Ala
405 410 415

Ala Ala Glu Arg Arg Ala Val Asn Trp Leu Leu Ala Met Gln Ser Ser
420 425 430

Asp Gly Gly Trp Ala Ala Phe Asp Val Asp Asn Asn Trp Ala Met Leu
435 440 445

Asn Gln Val Pro Phe Ala Asp His Asn Ala Met Leu Asp Pro Thr Cys
450 455 460

Pro Asp Ile Thr Gly Arg Val Leu Glu Cys Leu Cys Arg Arg Gly Met
465 470 475 480

Ala Gly His Asp Ala Ala Arg Arg Gly Val Ala Tyr Leu Leu Gln Ala
485 490 495

Gln Glu Lys Asp Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile
500 505 510

Tyr Gly Ser Phe Leu Ala Met Arg Gly Leu Thr Thr Ser Gly Ala Pro
515 520 525

Gly Ser Gln Asp Ala Val Asp Arg Ala Ala Arg Trp Leu Arg Ala Ile
530 535 540

Gln Asn Pro Asp Gly Gly Trp Gly Glu Ser Cys Ala Ser Tyr Ala Arg
545 550 555 560

Asp Gly Tyr Val Ala Ala Pro Ser Ser Ala Ser Gln Thr Ala Trp Ala
565 570 575

Leu Leu Gly Leu Cys Ala Ala Gly Asp Arg Asp Ser Ala Gln Phe Arg
580 585 590

Arg Gly Val Glu Tyr Leu Leu Thr Leu Gln Ala Pro Asp Gly Lys Trp
595 600 605

Pro Glu Gly Ala Thr Thr Gly Thr Gly Phe Pro Asn Val Phe Tyr Leu
610 615 620

Thr Tyr Ala Met Tyr Arg Asp Tyr Phe Pro Leu Leu Ala Leu Ser Gln
625 630 635 640

Val


<210> 112
<211> 641
<212> PRT
<213> Candidatus Solibacter

<400> 112
Met Ser Ala Pro Ser His Val Gly Asn Thr Leu Glu His Ala Ala Glu
1 5 10 15

Leu Ala Thr Arg Lys Ala Met Ala Tyr Leu Thr Cys Leu Gln Glu Arg
20 25 30

Asp Gly His Trp Cys Ala Glu Leu Thr Ala Asp Thr Thr Leu Glu Ser
35 40 45

Asp Tyr Ile Leu Phe Gln Leu Trp Leu Tyr Pro Pro Gln Asp Gly Lys
50 55 60

Trp Glu Pro Glu Thr Arg Pro Leu Ile Arg Lys Ala Val Asn Ser Ile
65 70 75 80

Leu Glu Arg Gln Leu Pro Asp Gly Gly Phe Asn Ile Cys Val Gly Gly
85 90 95

Pro Ser Glu Val Ser Ala Ser Val Lys Ala Tyr Val Ala Met Lys Leu
100 105 110

Ala Gly Leu Pro Pro Glu Asp Asp Arg Met Ala Arg Leu Arg Glu Arg
115 120 125

Ile Leu Ala Leu Gly Gly Ile Gln Ala Ala Asn Ser Tyr Val Lys Val
130 135 140

Asn Leu Ser Leu Phe Asp Leu Tyr Pro Arg Glu Phe Ser Pro Ser Ile
145 150 155 160

Pro Pro Glu Val Ala Leu Leu Pro Phe Asp Leu Leu Tyr Gln Met Ser
165 170 175

Ala Trp Thr Arg Ala Ile Val Ile Ser Leu Gly Ile Val His Ala Ala
180 185 190

Asn Pro Arg Arg Pro Ala Pro Ala Gly Phe Asn Leu Gln Glu Leu Trp
195 200 205

Leu Pro Gly Val Ser Pro Glu Phe Arg Arg Asp Pro Ser Phe Phe Thr
210 215 220

Trp His Asn Thr Phe Leu Thr Val Asp Lys Ala Leu Lys Leu Trp Glu
225 230 235 240

Arg Tyr Gly Ser Lys Ala Val Arg Arg Arg Ala Val Glu Lys Ala Lys
245 250 255

Thr Trp Met Ile Glu Arg Leu His His Ser Asp Gly Leu Gly Ala Ile
260 265 270

Tyr Pro Pro Met Met Tyr Ser Val Met Ala Leu Asp Val Leu Gly Tyr
275 280 285

Ala Lys Asp Asp Pro Leu Arg Val Glu Ala Leu Arg His Phe Asn Asn
290 295 300

Leu Met Val Asp Asp Gly Asp Arg Phe Phe Phe Gln Pro Cys Phe Ser
305 310 315 320

Pro Val Trp Asp Thr Ala Ile Gly Ala Tyr Ala Leu Val Gln Ala Asp
325 330 335

Pro Ser His Glu Ala Ile Ala Pro Ala Ala Asp Trp Leu Ile Ala Lys
340 345 350

Glu Val Arg Arg Lys Gly Asp Trp Ser Val Lys Arg Pro Asn Thr Glu
355 360 365

Pro Ser Gly Trp Ala Phe Glu Tyr Ser Asn Glu Tyr Tyr Pro Asp Ile
370 375 380

Asp Asp Thr Ala Met Val Met Leu Ala Leu Gly Glu Thr Arg Ala Ser
385 390 395 400

Asn Thr Glu Ala Gln Ala Ala Ala Cys Lys Arg Gly Leu Ala Trp Leu
405 410 415

Leu Ala Met Gln Ser Ser Asp Gly Gly Trp Ala Ala Phe Asp Ala Asp
420 425 430

Asn Asn Trp Glu Phe Leu Ser Gln Val Pro Phe Ala Asp His Asn Ala
435 440 445

Met Leu Asp Pro Thr Cys Ala Asp Ile Thr Gly Arg Val Leu Glu Ala
450 455 460

Leu Ala Ser Gln Gly Leu Asp Arg Asn His Lys Ala Val Arg Arg Gly
465 470 475 480

Ala Glu Trp Leu Ile Arg His Gln Glu Asn Asp Gly Ser Trp Tyr Gly
485 490 495

Arg Trp Gly Val Ala Tyr Ile Tyr Gly Thr Cys Phe Ala Leu Arg Gly
500 505 510

Leu Ala Ala Ser Gly Glu Asn Asp Arg Glu Ala His Ile Leu Arg Ala
515 520 525

Gly Glu Trp Leu Arg Ser Ile Gln Asn Ala Asp Gly Gly Trp Gly Glu
530 535 540

Ser Cys Lys Ser Tyr Asp Asn Arg Ile Phe Thr Gly Gly Pro Ser Thr
545 550 555 560

Pro Ser Gln Thr Ala Trp Ala Ile Leu Gly Leu Ile Ala Gly Gly Asp
565 570 575

Ala Asn Ser Leu Ser Val Gln His Gly Ile Glu Tyr Leu Leu Glu Thr
580 585 590

Gln Arg Ser Asp Gly Ser Trp Asp Glu Gln Phe Ala Thr Gly Thr Gly
595 600 605

Phe Pro Arg Val Phe Tyr Leu Asn Tyr His Met Tyr Lys Asp Tyr Phe
610 615 620

Pro Leu Leu Ala Leu Ala Ser Phe Val Lys Ala Arg Ala Gly Ser Asn
625 630 635 640

Gly


<210> 113
<211> 644
<212> PRT
<213> Catenulispora acidiphila

<400> 113
Met Thr Asp Val Ile Asp Lys Ala Val Ala Ala Thr Gly Pro Ala Asp
1 5 10 15

Pro Ser Gln Gly Ala Ala Ala Thr Leu Gln Ala Ala Ala Asp His Leu
20 25 30

Leu Gly Leu Gln Asp Asp Ala Gly Trp Trp Lys Gly Glu Leu Glu Thr
35 40 45

Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Gly
50 55 60

Ile Arg Thr Glu Glu Val Thr Arg Glu Ala Gly Asp Trp Ile Arg Ser
65 70 75 80

Gln Gln Arg Ala Asp Gly Thr Trp Ala Asn Phe Phe Asp Gly Pro Ala
85 90 95

Asp Leu Ser Thr Thr Ile Glu Ala Tyr Thr Ala Leu Arg Met Ala Gly
100 105 110

Asp Ala Lys Asp Ala Glu His Met Arg Ala Ala Arg Thr Tyr Ile Leu
115 120 125

Asp Ser Gly Gly Ile Glu Ala Ser Arg Val Phe Thr Arg Ile Trp Leu
130 135 140

Ala Leu Phe Gly Glu Trp Gln Trp Ser Asp Leu Pro Val Met Pro Pro
145 150 155 160

Glu Leu Ile Tyr Leu Pro Lys Trp Phe Pro Leu Asn Val Tyr Asp Trp
165 170 175

Ala Cys Trp Ala Arg Gln Thr Val Val Pro Leu Thr Ile Val Asn Ala
180 185 190

Leu Arg Pro Val Arg Pro Leu Gly Phe Asp Leu Lys Glu Leu Arg Thr
195 200 205

Gly Arg Arg Ala Pro Ala Gln Arg Gly Leu Phe Ser Thr Leu Asp Arg
210 215 220

Ala Leu His Val Tyr Glu Arg Lys Pro Leu Arg Ser Val Arg Asp Ala
225 230 235 240

Ala Leu Arg Arg Ser Ala Asp Trp Ile Ile Ala Arg Gln Glu Ala Asp
245 250 255

Gly Ser Trp Gly Gly Ile Gln Pro Pro Trp Val Tyr Ser Leu Met Ala
260 265 270

Leu Asn Leu Leu Gly Tyr Gly Val Asp His Pro Val Met Arg Lys Gly
275 280 285

Ile Glu Gly Leu Asp Arg Phe Thr Ile Arg Asp Glu Arg Gly Arg Arg
290 295 300

Leu Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Val Leu Ala Met Thr
305 310 315 320

Ala Leu Arg Asp Ala Glu Leu Pro Glu Asn His Pro Ala Leu Val Lys
325 330 335

Ala Ala Asp Trp Val Leu Gly Glu Glu Ile Thr Asn Pro Gly Asp Trp
340 345 350

Ser Val Arg Arg Pro Arg Val Ala Pro Gly Gly Trp Ala Phe Glu Phe
355 360 365

Asp Asn Asp Gly Tyr Pro Asp Val Asp Asp Thr Ala Glu Val Val Leu
370 375 380

Ala Leu Asn Arg Val Ala His Pro Asp Ala Pro Ala Ala Ile Arg Arg
385 390 395 400

Gly Val Asp Trp Leu Glu Gly Met Ala Cys Lys Asp Gly Gly Tyr Gly
405 410 415

Ala Phe Asp Ala Asp Asn Thr Arg Thr Leu Ala Leu Lys Leu Pro Phe
420 425 430

Cys Asp Phe Gly Ala Val Ile Asp Pro Pro Thr Ala Asp Val Thr Ala
435 440 445

His Thr Leu Glu Ala Tyr Ala Ala Leu Gly Leu Ala Asn Ser Arg Ala
450 455 460

Ser Gln Arg Ala Leu Glu Trp Leu Val Lys Ala Gln Glu Arg Asp Gly
465 470 475 480

Ser Trp Phe Gly Arg Trp Gly Ala Asn His Val Tyr Gly Thr Gly Ala
485 490 495

Val Val Pro Ala Met Val Ala Val Gly Val Asp Pro Glu Asp Glu Met
500 505 510

Ile Arg Arg Ala Val Arg Trp Leu Glu Glu His Gln Asn Asp Asp Gly
515 520 525

Gly Trp Gly Glu Asp Leu Arg Ser Tyr Arg Asp Lys Ser Trp Ile Gly
530 535 540

Arg Gly Val Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu
545 550 555 560

Leu Ala Ala Gly Glu Glu Arg Gly Thr Ala Val Glu Gln Gly Val Arg
565 570 575

Phe Leu Ile Arg Thr Gln Arg Ala Asp Gly Thr Trp Asp Glu Asp His
580 585 590

Tyr Thr Gly Thr Gly Phe Pro Gly Asp Phe Tyr Leu Asn Tyr His Leu
595 600 605

Tyr Arg Leu Val Phe Pro Ile Ser Ala Leu Gly Arg Tyr Val Arg Ala
610 615 620

Val Gly Ala Ala Gly Asp Gly Gly Asp Ala Gly His Ala Gly His Ala
625 630 635 640

Gly Thr Val Ser


<210> 114
<211> 657
<212> PRT
<213> Chthoniobacter flavus

<400> 114
Met Ile Phe Thr Asp Thr Pro Thr Gly Ser Thr Gln Asn Arg Leu Asp
1 5 10 15

Val Ala Ile Arg Arg Ala Gln Gln Asn Leu Leu Arg Leu Gln His Asn
20 25 30

Glu Gly Tyr Trp Cys Gly Glu Leu Phe Val Asp Ser Thr Leu Cys Ser
35 40 45

Asp Tyr Val Leu Phe Met His Trp Ala Asp Glu Ile Asp Pro Val Met
50 55 60

Glu Glu Lys Cys Val Ala His Ile Arg Arg Arg Gln Leu Glu Asp Gly
65 70 75 80

Gly Trp Asn Ile Tyr Glu Gly Gly Pro Ser Asp Val Asn Ala Thr Val
85 90 95

Lys Ala Tyr Phe Ala Leu Lys Leu Ala Gly His Ala Pro Thr Gln Pro
100 105 110

Trp Met Gln Glu Ala Arg Ala Cys Ile Leu Arg Leu Gly Gly Ile Pro
115 120 125

Lys Met Asn Thr Tyr Ala Lys Leu Tyr Leu Ala Leu Leu Gly Gln Phe
130 135 140

Pro Trp Arg Tyr Leu Pro Thr Val Pro Val Glu Ile Met Phe Met Pro
145 150 155 160

Arg Trp Phe Phe Phe Asp Ile Tyr Glu Val Ser Ser Trp Ser Arg Ala
165 170 175

Met Leu Met Pro Leu Ala Ile Leu Asn His Tyr Lys Pro Thr Lys His
180 185 190

Leu Pro Ala Asp Lys Gln Leu His Glu Leu Tyr Pro Ile Gly Ser Glu
195 200 205

Glu Ser Asp Leu Gly Leu Gly Met Gln Lys Pro Arg Phe Ser Trp Pro
210 215 220

Asn Phe Phe Leu Phe Cys Asp Arg Leu Ile Lys Ile Met His Ser Leu
225 230 235 240

Pro Trp Lys Pro Trp Lys Arg Ala Ala Leu Ala Arg Ala Glu Ala Trp
245 250 255

Met Thr Gln Arg Met Gly Glu Gly Ser Asp Gly Leu Ala Ala Ile Phe
260 265 270

Pro Ala Met Leu Asn Ser Met Ile Ala Leu Arg Thr Leu Arg Tyr Ser
275 280 285

Arg Glu His Pro Leu Tyr Val Lys Ala Lys Asn Asp Phe Ala Gly Leu
290 295 300

Phe Val Asp Asp Pro Gln Asp Phe Arg Ile Gln Pro Cys Leu Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Ile Asn Leu Val Ala Leu Leu Glu Ser Gly Leu
325 330 335

Asp Pro His Asp Pro Lys Ile Glu Ala Ala Val Asn Trp Leu Lys Glu
340 345 350

Lys Glu Val Arg Ile Asn Gly Asp Trp Tyr Val Lys Asn His His Val
355 360 365

Pro Pro Ser Gly Trp Ala Phe Glu Phe Asn Asn Val Tyr Tyr Pro Asp
370 375 380

Thr Asp Asp Thr Met Met Val Leu Ala Ala Leu Ala Arg Ala Gly Ala
385 390 395 400

His Glu Glu Ser Ala Pro Val Glu Thr Lys Ala Met Phe Glu Arg Ala
405 410 415

Leu Lys Trp Leu Leu Ser Phe Gln Cys Arg Asp Gly Gly Trp Ala Ala
420 425 430

Phe Asp Lys Asp Val Thr Gln Gly Trp Leu Glu Asp Val Pro Phe Ala
435 440 445

Asp His Asn Ala Ile Leu Asp Pro Thr Cys Ser Asp Leu Thr Gly Arg
450 455 460

Val Leu Glu Leu Leu Gly Leu Ile Asp Tyr Asp Arg Asn Cys Thr Pro
465 470 475 480

Val Arg Arg Ala Leu Lys Phe Leu Arg Asp Thr Gln Glu Asp Asp Gly
485 490 495

Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Gln
500 505 510

Val Leu Arg Gly Leu Arg Ser Ile Gly Glu Asp Met Arg Gln Gln Trp
515 520 525

Ile Val Arg Ala Arg Asp Trp Leu Glu Ser Cys Gln Asn Glu Asp Gly
530 535 540

Gly Trp Gly Glu Thr Cys Ala Ser Tyr Asp Asp Pro Thr Leu Lys Gly
545 550 555 560

Lys Gly Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Gly Leu
565 570 575

Ile Ala Ala Ala Asp Pro Thr Glu Pro Gly Ala Phe Asp Arg Lys Ser
580 585 590

Ile Arg Gln Gly Val Asp Tyr Leu Leu Ser Thr Gln Val Ala Asp Gly
595 600 605

Ser Trp Val Glu Pro Glu Val Thr Gly Thr Gly Phe Pro Arg Val Phe
610 615 620

Tyr Leu Arg Tyr Asp Met Tyr Arg Asn Asn Phe Pro Leu Met Ala Leu
625 630 635 640

Ala Thr Tyr Arg Lys Ala Arg Glu Gly Lys Leu Pro Val Arg Gln Arg
645 650 655

Glu


<210> 115
<211> 603
<212> PRT
<213> Chthoniobacter flavus

<400> 115
Met Glu Thr Leu Ser Arg Ser Arg Leu Glu Ala Ala Leu Ala Lys Ala
1 5 10 15

Thr Gln Ala Leu Leu Thr Glu Leu Asn Pro Ala Gly His Trp Ser Gly
20 25 30

Glu Leu Ser Ser Ser Ala Leu Ser Thr Ala Thr Ala Ile Val Ala Leu
35 40 45

Gly Ala Val Asp Arg Glu Gln Gln Arg Glu Leu Ile Ala Gly Gly Met
50 55 60

Arg Trp Leu Ala Gln His Gln Asn Ala Asp Gly Gly Trp Gly Asp Thr
65 70 75 80

Val Lys Ser Arg Ser Asn Ile Ser Thr Thr Ala Leu Cys Trp Ala Ala
85 90 95

Val Ser Thr Ser Thr Glu His Ala Glu Ser Ala Ala Lys Ala Glu Ala
100 105 110

Trp Leu Thr Arg Ala Ala Gly Ser Met Ala Gln Leu Val Pro Ala Ile
115 120 125

Glu Ala Arg Tyr Gly Lys Asp Arg Thr Phe Ser Val Pro Ile Leu Met
130 135 140

His Leu Ala Ile Cys Gly Arg Val Ser Trp Ser Gln Ile Pro Ala Leu
145 150 155 160

Pro Phe Glu Leu Ala Ala Leu Pro His Gln Leu Phe Gly Ala Leu Gln
165 170 175

Leu Pro Val Val Ser Tyr Ala Leu Pro Ala Leu Ile Ala Ile Gly Gln
180 185 190

Ala Ile His His His Ala Pro Pro Thr Asn Pro Leu Leu Asn Gly Leu
195 200 205

Arg Lys Ser Ala Arg Ala Arg Thr Leu Glu Val Leu Glu Ser Ile Gln
210 215 220

Pro Gln Asn Gly Gly Phe Leu Glu Ala Thr Pro Leu Thr Ser Phe Val
225 230 235 240

Thr Met Ala Leu Ala Ser Ala Gly Glu Ala Gln His Pro Val Ala Arg
245 250 255

Arg Gly Val Ser Phe Leu Gln Ala Ser Val Gln Arg Asp Gly Ser Trp
260 265 270

Ala Ile Asp Thr Asn Leu Ala Thr Trp Val Thr Thr Leu Ser Ile Lys
275 280 285

Ala Leu Ala His Gln Pro Gly Ala Leu Ser Pro Glu Arg Ala Leu Thr
290 295 300

Leu Arg Glu Trp Leu Leu Gly Gln Gln Tyr Val Val Glu His Pro Tyr
305 310 315 320

Thr His Ala Ala Pro Gly Gly Trp Ala Trp Thr Asp Leu Pro Gly Gly
325 330 335

Val Pro Asp Ala Asp Asp Thr Pro Gly Ala Leu Leu Ala Leu Leu His
340 345 350

Leu Gly Val Val Asp Ala Pro Thr Arg Gln Ala Gly Gln Ile Gly Val
355 360 365

Arg Trp Leu Leu Asp Leu Gln Asn Arg Asp Gly Gly Ile Pro Thr Phe
370 375 380

Cys Arg Gly Trp Gly Ala Leu Pro Phe Asp Arg Ser Ser Pro Asp Leu
385 390 395 400

Thr Ala His Thr Leu Arg Ala Trp Thr Ala Trp Leu Pro Gln Leu Asp
405 410 415

Glu Ser Leu Lys Arg Arg Thr Leu Arg Ala Val Thr Lys Ala Ile His
420 425 430

Phe Leu Ala Thr His Gln Arg Thr Asp Gly Ser Trp Leu Pro Leu Trp
435 440 445

Phe Gly Asn Glu His Ala Pro Asp Asp Glu Asn Pro Leu Tyr Gly Thr
450 455 460

Ala Lys Val Val Ile Ala Leu Arg Glu Leu Leu Asn Arg Asp Phe Thr
465 470 475 480

Leu Pro Asn Gly Met Leu Glu Arg Ala Leu Cys Trp Leu Val Glu Arg
485 490 495

Gln Asp Ile Ser Gly Gly Trp Ser Gly Ala Lys Asn Gly Pro Val Ser
500 505 510

Val Glu Glu Thr Ala Leu Ala Val Glu Ala Leu Ala Gly Thr Gly His
515 520 525

Val Ser Ala Thr Asp Arg Gly Ala Ala Trp Leu Thr Glu Gln Ile Glu
530 535 540

Ala Asp Thr Trp Arg Glu Pro Ala Pro Ile Gly Phe Tyr Phe Ala Lys
545 550 555 560

Leu Trp Tyr Tyr Glu Arg Leu Tyr Pro Gln Ile Trp Thr Val Gly Ala
565 570 575

Leu Gly Arg Val Ala Ala Leu Arg Val Gly Glu Ser Glu Ser Asp Thr
580 585 590

Pro Ala Gly Leu His Arg Ala Thr Ser Glu Thr
595 600


<210> 116
<211> 645
<212> PRT
<213> Crocosphaera watsonii

<400> 116
Met Gln Thr Gln Asp Arg Leu Thr Gln Lys Gln Pro Leu Ser Leu Lys
1 5 10 15

Asp Ala Ile Thr Ala Ser Gln Asn Tyr Leu Leu Ser Leu Gln Tyr Pro
20 25 30

Gln Gly Tyr Trp Trp Ala Glu Leu Glu Ser Asn Ile Thr Leu Thr Ala
35 40 45

Glu Thr Val Leu Leu His Lys Ile Trp Gly Thr Asp Lys Thr Arg Pro
50 55 60

Leu His Lys Val Glu Ala Tyr Leu Arg Gln Gln Gln Arg Glu His Gly
65 70 75 80

Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Glu Ile Ser Thr Ser Val
85 90 95

Glu Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Pro Gln Asp Asp Pro
100 105 110

Ala Leu Ile Arg Ala Lys Asp Phe Ile Ile Ser Lys Gly Gly Ile Ser
115 120 125

Lys Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile Gly Cys Tyr
130 135 140

Asp Trp Lys Gly Ile Pro Ser Ile Pro Pro Trp Ile Met Leu Phe Pro
145 150 155 160

Asp Ser Phe Pro Phe Thr Ile Tyr Glu Met Ala Ser Trp Ala Arg Glu
165 170 175

Ser Thr Val Pro Leu Ile Ile Val Phe Asn Asp Lys Pro Val Phe Ser
180 185 190

Val Asp Pro Val Phe Asn Leu Asp Glu Leu Tyr Ala Glu Gly Val Glu
195 200 205

Asn Val Lys Tyr Glu Leu Pro Lys Asn Asn Asn Trp Gly Asp Ile Phe
210 215 220

Leu Gly Ile Asp Gln Val Phe Lys Phe Ala Glu Gln Val Asp Leu Val
225 230 235 240

Pro Phe Arg Lys Glu Gly Leu Lys Ala Ala Glu Lys Trp Ile Leu Asn
245 250 255

His Gln Gln Glu Thr Gly Asp Trp Gly Gly Ile Met Pro Pro Met Leu
260 265 270

Asn Ser Leu Leu Ala Phe Arg Thr Leu Asn Tyr Asp Val Asn Asp Pro
275 280 285

Ser Val Lys Leu Gly Phe Glu Ala Ile Asp Arg Phe Ser Ile Glu Glu
290 295 300

Asp Asp Thr Tyr Arg Leu Gln Ala Cys Val Ser Pro Ile Trp Asp Thr
305 310 315 320

Ala Trp Cys Val Arg Ala Leu Thr Asp Ser Gly Leu Glu Lys Asp His
325 330 335

Phe Ser Leu Val Lys Ala Gly Lys Trp Leu Leu Asp Lys Gln Val Met
340 345 350

Glu Tyr Gly Asp Trp Ala Val Lys Asn Lys Ala Gly Lys Pro Gly Gly
355 360 365

Trp Ala Phe Glu Phe Thr Asn Arg Phe Tyr Pro Asp Leu Asp Asp Ser
370 375 380

Ala Thr Val Val Met Ala Leu Asn Gly Ile Lys Leu Pro Asp Glu Ala
385 390 395 400

Arg Lys Gln Ala Ala Ile Asn Arg Cys Leu Gln Trp Ile Glu Thr Met
405 410 415

Gln Cys Lys Glu Gly Gly Trp Ala Ala Phe Asp Leu Asn Asn Asp Gln
420 425 430

Ala Trp Leu Asn Glu Val Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp
435 440 445

Pro Asn Thr Ala Asp Val Thr Ala Arg Val Val Glu Met Leu Gly Ser
450 455 460

Cys Asp Leu Glu Ile Glu Ser Asp Arg Leu Asn Lys Ser Leu Asn Tyr
465 470 475 480

Leu Tyr Lys Glu Gln Glu Lys Asp Gly Ser Trp Phe Gly Arg Trp Gly
485 490 495

Val Asn Tyr Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala Leu Ala Val
500 505 510

Ile Asn Pro Glu Lys His Lys Thr Gln Met Glu Gln Gly Ile Asn Trp
515 520 525

Leu Leu Ser Cys Gln Asn Lys Asp Gly Gly Trp Gly Glu Thr Cys Arg
530 535 540

Ser Tyr Asn Asp Pro Ser Leu Lys Gly Lys Gly Val Ser Thr Pro Ser
545 550 555 560

Gln Thr Ala Trp Ser Leu Ile Gly Leu Leu Asp Ala Gly Glu Ala Leu
565 570 575

Asn Lys Phe Glu Thr Asp Ala Ile Glu Arg Gly Val Asn Tyr Leu Leu
580 585 590

Asp Thr Gln Thr Glu Glu Gly Thr Trp Glu Glu Ser Glu Phe Thr Gly
595 600 605

Thr Gly Phe Pro Cys His Phe Tyr Ile Arg Tyr His Phe Tyr Arg His
610 615 620

Tyr Phe Pro Leu Ile Ala Leu Gly Arg Tyr Gln Asn Leu Ser Ser Glu
625 630 635 640

Phe Gly Val Arg Ser
645


<210> 117
<211> 681
<212> PRT
<213> Cupriavidus taiwanensis

<400> 117
Met Asn Glu Thr Ala Phe Ala Asn Pro Ala Pro Gln Val Gly Pro Ala
1 5 10 15

Gln Arg Gln Pro Ala Ala Pro Gln Glu Ala Pro Ala Ala Arg Leu Pro
20 25 30

Ala Pro Ala Leu Asp Arg Gly Ile Asp Arg Ala Leu Asp Ala Leu Leu
35 40 45

His Gln Gln Arg Pro Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp
50 55 60

Ala Thr Ile Pro Ala Glu Tyr Val Leu Met Val His Tyr Leu Gly Glu
65 70 75 80

Asp Pro Asp Arg Asp Leu Glu Ala Arg Ile Ala Arg Tyr Leu Arg Arg
85 90 95

Ile Gln Asn Pro Asp Gly Gly Trp Pro Leu Phe His Gln Gly Arg Ser
100 105 110

Asp Ile Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Met Ala Gly
115 120 125

Asp Asp Pro Gln Ser Ala Pro Met Gln Arg Ala Arg Gln Ala Ile His
130 135 140

Ala Met Gly Gly Ala Glu Ala Thr Asn Val Phe Thr Arg Thr Leu Leu
145 150 155 160

Ala Leu Tyr Gly Val Leu Pro Trp Lys Ala Val Pro Met Met Pro Val
165 170 175

Glu Ile Met Leu Leu Pro Arg Trp Phe Pro Phe His Leu Ser Lys Val
180 185 190

Ser Tyr Trp Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ser
195 200 205

Leu Arg Pro Gln Ala Arg Asn Pro Arg Gly Val Gly Ile Asn Glu Leu
210 215 220

Phe Val Gly Asn Cys His Thr Val Gly Leu Pro Pro Arg Ala Ala His
225 230 235 240

Gln His Ala Gly Trp Tyr Thr Val Phe Arg Gly Leu Asp Ala Leu Leu
245 250 255

Arg Leu Ala Glu Pro Leu Phe Pro Arg Thr Leu Arg Arg Arg Ala Ile
260 265 270

Ala Ala Ala Gln Arg Phe Val Arg Glu Arg Leu Asn Gly Glu Asp Gly
275 280 285

Leu Gly Ala Ile Phe Pro Ala Met Ala Asn Ser Val Met Met Phe Asp
290 295 300

Val Leu Gly Val Pro Pro Glu Asp Pro Ala Arg Ala Val Ala Arg Arg
305 310 315 320

Ser Ile Glu Arg Leu Leu Val Glu His Gly Asp Glu Ala Tyr Cys Gln
325 330 335

Pro Cys Leu Ser Pro Val Trp Asp Thr Ala Leu Ala Thr His Ala Leu
340 345 350

Leu Glu Thr Gly Glu Ala Arg Ala Ala Gln Ala Ala Gly Arg Ala Leu
355 360 365

Asp Trp Leu Arg Pro Leu Gln Val Leu Asp Leu Arg Gly Asp Trp Ala
370 375 380

Val Arg Arg Pro Leu Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala
385 390 395 400

Asn Ala Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Ala Ala
405 410 415

Met Asp Arg Phe Met Arg Ala His His Ala Pro Gly Arg Tyr Gly Glu
420 425 430

Ala Val Ala Arg Ala Thr Glu Trp Ile Val Gly Met Gln Ser Gly Asn
435 440 445

Gly Gly Trp Gly Ala Phe Glu Pro Glu Asn Thr His Leu Tyr Leu Asn
450 455 460

Asn Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala
465 470 475 480

Asp Val Ser Ala Arg Cys Leu Ser Met Leu Cys Gln Thr Gly Ala Thr
485 490 495

Pro Ala Asn Ser Glu Pro Ala Ala Arg Ala Leu Arg Tyr Leu Leu Ala
500 505 510

Glu Gln Met Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr
515 520 525

Ile Tyr Gly Thr Trp Ser Ala Leu Cys Ala Leu Asn Ala Ala Gly Leu
530 535 540

Pro Pro Glu Ala Pro Glu Leu Cys Arg Ala Val Ala Trp Leu Ala Arg
545 550 555 560

Ile Gln Asn Ala Asp Gly Gly Trp Gly Glu Asp Gly Ser Ser Tyr Arg
565 570 575

Leu Asp Tyr Ser Gly Tyr Glu Pro Ala Pro Ser Val Ala Ser Gln Thr
580 585 590

Ala Trp Ala Leu Leu Ala Leu Met Ala Ala Gly Ala Ala Gln His Pro
595 600 605

Ala Val Ala Arg Gly Ile Asp Tyr Leu Leu Arg Thr Gln Gln Pro Gly
610 615 620

Gly Leu Trp His Glu Pro Arg Phe Thr Ala Val Gly Phe Pro Arg Val
625 630 635 640

Phe Tyr Leu Arg Tyr His Gly Tyr Ala Arg Tyr Phe Pro Leu Trp Ala
645 650 655

Leu Ala Arg Tyr Arg Asn Leu Gln Arg Gly Leu Gly Asp His Gly Gly
660 665 670

Asn Ser Gly Gln Val Ala Trp Gly Leu
675 680


<210> 118
<211> 663
<212> PRT
<213> Cyanothece sp.

<400> 118
Met Leu Thr Tyr Lys Glu Tyr Arg Arg Ser Val Thr Glu Ile Ala Met
1 5 10 15

Gln Thr Arg Asp Arg Gln Thr Gln Lys Pro Ala Leu Ser Leu Asn Asp
20 25 30

Ala Ile Thr Ala Ser Gln Asn Tyr Leu Leu Ser Leu Gln Tyr Pro Gln
35 40 45

Gly Tyr Trp Trp Ala Glu Leu Glu Ser Asn Ile Thr Leu Thr Ala Glu
50 55 60

Thr Val Leu Leu His Lys Ile Trp Gly Thr Asp Lys Thr Arg Pro Leu
65 70 75 80

His Lys Val Glu Ala Tyr Leu Arg Gln Gln Gln Arg Glu Gln Gly Gly
85 90 95

Trp Glu Leu Phe Tyr Gly Asp Gly Gly Glu Ile Ser Thr Ser Val Glu
100 105 110

Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Pro Gln Asp Asp Pro Ala
115 120 125

Leu Ile Arg Ala Lys Asp Phe Ile Leu Ser Lys Gly Gly Ile Ser Lys
130 135 140

Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile Gly Cys Tyr Ser
145 150 155 160

Trp Lys Gly Ile Pro Ser Ile Pro Pro Trp Ile Met Leu Phe Pro Asn
165 170 175

Ser Phe Pro Phe Thr Ile Tyr Glu Met Ala Ser Trp Ala Arg Glu Ser
180 185 190

Thr Val Pro Leu Ile Ile Val Phe Asn Asp Lys Pro Val Phe Ala Val
195 200 205

Asp Pro Ile Phe Asn Leu Asp Glu Leu Tyr Ala Glu Gly Ile Glu Asn
210 215 220

Val Lys Tyr Glu Leu Pro Lys Asn Asn Asn Trp Gly Asp Ile Phe Leu
225 230 235 240

Gly Leu Asp Lys Val Phe Lys Phe Ala Glu Gln Val Asp Leu Val Pro
245 250 255

Phe Arg Lys Lys Gly Leu Gln Ala Ala Glu Arg Trp Met Leu Asn His
260 265 270

Gln Gln Glu Thr Gly Asp Trp Gly Gly Ile Met Pro Pro Met Val Asn
275 280 285

Ser Leu Leu Ala Phe Arg Val Leu Asn Tyr Asp Val Asn Asp Pro Ser
290 295 300

Val Gln Arg Gly Phe Glu Ala Ile Asp Arg Phe Ser Ile Glu Glu Asn
305 310 315 320

Glu Thr Tyr Arg Val Gln Ala Cys Val Ser Pro Val Trp Asp Thr Ala
325 330 335

Trp Cys Val Arg Ala Leu Thr Asn Ser Gly Leu Pro Lys Asp His Phe
340 345 350

Ser Leu Val Lys Ala Gly Lys Trp Leu Leu Glu Lys Gln Cys Leu Glu
355 360 365

Tyr Gly Asp Trp Ala Val Lys Asn Lys Thr Gly Lys Pro Gly Gly Trp
370 375 380

Ala Phe Glu Phe Thr Asn Arg Phe Tyr Pro Asp Ile Asp Asp Ser Ala
385 390 395 400

Val Val Val Met Ala Leu Asn Gly Ile Lys Leu Pro Asp Glu Ala Arg
405 410 415

Lys Gln Ala Ala Ile Asn Arg Cys Val Lys Trp Ile Glu Thr Met Gln
420 425 430

Cys Lys Glu Gly Gly Trp Ala Ala Phe Asp Val Asp Asn Asp Gln Ala
435 440 445

Trp Leu Asn Glu Val Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp Pro
450 455 460

Asn Thr Ala Asp Val Thr Ala Arg Val Val Glu Met Val Gly Ser Cys
465 470 475 480

Asp Leu Glu Ile Ser Ser Lys Arg Leu Asn Lys Ala Leu Asn Tyr Leu
485 490 495

Tyr Lys Glu Gln Glu Lys Asp Gly Ser Trp Phe Gly Arg Trp Gly Val
500 505 510

Asn Tyr Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala Leu Ala Val Ile
515 520 525

Asn Pro Glu Lys His Gln Pro Gln Ile Glu Gln Gly Ile Asn Trp Leu
530 535 540

Leu Ser Cys Gln Asn Lys Asp Gly Gly Trp Gly Glu Thr Cys Trp Ser
545 550 555 560

Tyr Asn Asp Ser Asn Leu Lys Gly Lys Gly Ile Ser Thr Ala Ser Gln
565 570 575

Thr Ala Trp Ala Leu Ile Gly Leu Leu Asp Ala Gly Glu Ala Leu Asn
580 585 590

His Phe Glu Thr Asp Ser Ile Gln Arg Gly Ile Ser Tyr Leu Leu Asn
595 600 605

Thr Gln Thr Glu Glu Gly Thr Trp Glu Glu Ser Glu Phe Thr Gly Thr
610 615 620

Gly Phe Pro Cys His Phe Tyr Ile Arg Tyr His Phe Tyr Arg His Tyr
625 630 635 640

Phe Pro Leu Ile Ala Leu Gly Arg Tyr Gln Asn Leu Ser Ser Glu Phe
645 650 655

Gly Ile Arg Asn Ser Glu Leu
660


<210> 119
<211> 643
<212> PRT
<213> Cyanothece sp.

<400> 119
Met Gln Ile Gln Asp Arg Asn Ser Ser Pro Gln Val Thr Glu Val Leu
1 5 10 15

Asn Gln Val Lys Asp Ala Ile Ala Ala Ser Gln Asp Tyr Leu Met Ser
20 25 30

Ile Gln Tyr Pro Glu Gly Tyr Trp Trp Ala Glu Leu Glu Ser Asn Val
35 40 45

Thr Ile Thr Ala Glu Val Val Leu Leu His Lys Ile Trp Gly Thr Asp
50 55 60

Lys Thr Arg Pro Leu His Lys Val Glu Thr Tyr Leu Arg Arg Gln Gln
65 70 75 80

Arg Glu His Gly Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Asp Leu
85 90 95

Ser Thr Ser Val Glu Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Ser
100 105 110

Ile Asp Asp Pro Ala Leu Ile Arg Gly Arg Glu Phe Ile Leu Lys Arg
115 120 125

Gly Gly Ile Ser Lys Ser Arg Ile Phe Thr Lys Leu His Leu Ala Leu
130 135 140

Ile Gly Cys Tyr Asp Trp Arg Gly Ile Pro Ser Ile Pro Pro Trp Ile
145 150 155 160

Met Leu Leu Pro Glu Asn Phe Pro Phe Thr Ile Tyr Glu Met Ser Ser
165 170 175

Trp Ala Arg Ser Ser Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys
180 185 190

Pro Val Tyr Cys Cys Asp Pro Thr Ile Asn Leu Asp Glu Leu Tyr Ser
195 200 205

Glu Gly Ile Glu Asn Val Lys Tyr Asp Leu Pro Lys Thr Gly Asp Trp
210 215 220

Thr Asp Ile Phe Val Trp Leu Asp Gly Val Phe Lys Phe Ala Gln Asp
225 230 235 240

Tyr Asn Leu Val Pro Leu Arg Gln Glu Ser Leu Gln Ala Ala Glu Arg
245 250 255

Trp Val Leu Glu Arg Gln Glu Asp Ser Gly Asp Trp Gly Gly Ile Ile
260 265 270

Pro Ala Met Leu Asn Ser Leu Leu Ala Leu Arg Ala Leu Asn Tyr Glu
275 280 285

Ala Val Asp Pro Ile Val His Arg Gly Leu Gln Ser Val Asp Asn Phe
290 295 300

Ala Ile Glu Thr Glu Asp Thr Tyr His Val Gln Pro Cys Ile Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Trp Ala Ile Arg Ala Leu Val Glu Ser Gly Leu
325 330 335

Lys Ala Asp Asp Pro Arg Leu Val Lys Gly Ala Gln Trp Leu Leu Asp
340 345 350

Lys Gln Ile Leu Asp Tyr Gly Asp Trp Ala Val Lys Asn Lys Gln Gly
355 360 365

Thr Pro Gly Gly Trp Ala Phe Glu Phe Asp Asn Arg Trp Tyr Pro Asp
370 375 380

Leu Asp Asp Ser Ala Val Val Val Met Ala Leu Asp Gln Val Lys Met
385 390 395 400

Pro Asn Glu Asp Leu Lys Asn Gly Ala Ile Arg Arg Cys Val Arg Trp
405 410 415

Met Ala Thr Met Gln Cys Lys Asp Gly Gly Trp Gly Ala Phe Asp Leu
420 425 430

Asp Asn Asp Gln Asn Trp Leu Asn Phe Leu Pro Tyr Ala Asp Leu Lys
435 440 445

Ala Met Ile Asp Pro Asn Thr Ser Asp Val Thr Ala Arg Val Leu Glu
450 455 460

Met Leu Gly Thr Cys Gly Leu Ile Met Asp Ser Asn Arg Val Gln Lys
465 470 475 480

Ala Ile Ala Tyr Leu Glu Lys Glu Gln Glu Pro Asp Gly Ser Trp Phe
485 490 495

Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Ser Gly Val Leu Ser
500 505 510

Ala Leu Ala Val Ile Ala Pro Glu Thr His Gln Lys Glu Leu Lys Lys
515 520 525

Gly Ala Ala Trp Leu Val Gly Cys Gln Asn Ala Asp Gly Gly Trp Gly
530 535 540

Glu Thr Cys Phe Ser Tyr Asn Asp Ser Ser Leu Lys Gly Lys Gly Asp
545 550 555 560

Ser Thr Ala Ser Gln Thr Ala Trp Gly Leu Ile Gly Leu Leu Ala Ala
565 570 575

Gly Glu Ala Thr Gly Glu Phe Phe Lys Thr Ala Ile Glu Arg Gly Val
580 585 590

Asn Tyr Leu Leu Lys Thr Gln Arg Glu Asp Gly Thr Trp Asp Glu Asn
595 600 605

Tyr Phe Thr Gly Thr Gly Phe Pro Cys His Phe Tyr Leu Lys Tyr His
610 615 620

Leu Tyr Leu Gln Tyr Phe Pro Leu Ile Ala Leu Ser Arg Tyr Gln Arg
625 630 635 640

Leu Leu Thr


<210> 120
<211> 651
<212> PRT
<213> Cyanothece sp.

<400> 120
Met Gln Thr Gln Asn Arg Val Thr Ser Thr Gln Lys Val Glu Leu Ser
1 5 10 15

Asn Leu Thr Gln Ala Ile Ile Ala Ser Gln Asn Tyr Ile Leu Ser Arg
20 25 30

Gln Tyr Pro Glu Gly Tyr Trp Trp Gly Glu Leu Glu Ser Asn Ile Thr
35 40 45

Leu Thr Ala Glu Thr Val Leu Leu His Lys Ile Trp Lys Thr Asp Lys
50 55 60

Thr Arg Pro Phe His Lys Val Glu Thr Tyr Leu Arg Arg Gln Gln Asn
65 70 75 80

Glu Gln Gly Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Glu Leu Ser
85 90 95

Thr Ser Val Glu Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Thr Pro
100 105 110

Glu Asp Pro Ala Leu Ile Arg Ala Lys Asp Phe Ile Leu Ser Lys Gly
115 120 125

Gly Ile Ser Lys Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile
130 135 140

Gly Cys Tyr Asp Trp Lys Gly Ile Pro Ser Ile Pro Pro Trp Ile Met
145 150 155 160

Leu Phe Pro Asp Asn Phe Pro Phe Thr Ile Tyr Glu Met Ser Ser Trp
165 170 175

Ala Arg Glu Ser Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys Pro
180 185 190

Ile Phe Glu Ile Glu Pro Ala Phe Asn Leu Asp Glu Leu Tyr Ala Glu
195 200 205

Gly Val Glu Asn Val Lys Tyr Ala Leu Pro Arg Asn His Asn Trp Ser
210 215 220

Asp Ile Phe Leu Gly Leu Asp Lys Leu Phe Lys Trp Thr Glu Lys Asn
225 230 235 240

Asn Leu Val Pro Phe His Lys Lys Ser Leu Gln Ala Ala Glu Lys Trp
245 250 255

Met Leu Asn His Gln Gln Glu Ser Gly Asp Trp Gly Gly Ile Met Pro
260 265 270

Pro Met Val Asn Ser Leu Ile Ala Phe Lys Val Leu Asn Tyr Asp Val
275 280 285

Ala Asp Pro Ser Val Gln Arg Gly Phe Glu Ala Ile Asp Arg Phe Ser
290 295 300

Ile Glu Glu Glu Asp Thr Tyr Arg Val Gln Ala Cys Val Ser Pro Val
305 310 315 320

Trp Asp Thr Ala Trp Val Ile Arg Ala Leu Val Asp Ser Gly Leu Lys
325 330 335

Pro Asp His Pro Ser Leu Val Lys Ala Gly Glu Trp Leu Leu Asp Lys
340 345 350

Gln Ile Leu Glu Tyr Gly Asp Trp Ala Ile Lys Asn Lys Gln Gly Lys
355 360 365

Pro Gly Gly Trp Ala Phe Glu Phe Ile Asn Arg Phe Tyr Pro Asp Leu
370 375 380

Asp Asp Ser Ala Val Val Val Met Ala Leu Asn Gly Ile Lys Leu Pro
385 390 395 400

Asp Glu Asn Arg Lys Lys Ala Ala Ile Asn Arg Cys Leu Glu Trp Met
405 410 415

Ala Thr Met Gln Cys Lys Pro Gly Gly Trp Ala Ala Phe Asp Val Asp
420 425 430

Asn Asp Gln Ala Trp Ile Asn Glu Ile Pro Tyr Gly Asp Leu Lys Ala
435 440 445

Met Ile Asp Pro Asn Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met
450 455 460

Val Gly Ser Cys Gly Leu Lys Met Asp Glu Asn Arg Val Gln Lys Ala
465 470 475 480

Leu Phe Tyr Leu Glu Lys Glu Gln Glu Ser Asp Gly Ser Trp Phe Gly
485 490 495

Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala
500 505 510

Leu Ala Val Ile Ala Pro Asn Thr His Lys Pro Gln Met Glu Lys Ala
515 520 525

Val Asn Trp Leu Ile Ser Cys Gln Asn Glu Asp Gly Gly Trp Gly Glu
530 535 540

Thr Cys Trp Ser Tyr Asn Asp Ser Ser Leu Lys Gly Thr Gly Ile Ser
545 550 555 560

Thr Ala Ser Gln Thr Ala Trp Ala Ile Ile Gly Leu Leu Asp Ala Gly
565 570 575

Glu Ala Leu Glu Thr Leu Ala Thr Asp Ala Ile Lys Arg Gly Ile Asp
580 585 590

Tyr Leu Leu Ala Thr Gln Thr Pro Asp Gly Thr Trp Glu Glu Ala Glu
595 600 605

Phe Thr Gly Thr Gly Phe Pro Cys His Phe Tyr Ile Arg Tyr His Leu
610 615 620

Tyr Arg His Tyr Phe Pro Leu Ile Ala Leu Gly Arg Tyr Trp Lys Ile
625 630 635 640

Gly Leu Lys Thr Pro Ser Val Ile Pro Leu Asn
645 650


<210> 121
<211> 647
<212> PRT
<213> Cyanothece sp.

<400> 121
Met Gln Thr Gln Asn Arg Val Thr Ser Thr Gln Lys Val Glu Leu Ser
1 5 10 15

Asn Leu Thr Lys Ala Ile Ile Ala Ser Gln Asn Tyr Ile Met Ser Arg
20 25 30

Gln Tyr Pro Glu Gly Tyr Trp Trp Gly Glu Leu Glu Ser Asn Ile Thr
35 40 45

Leu Thr Ala Glu Thr Ile Leu Leu His Lys Ile Trp Lys Thr Asp Lys
50 55 60

Thr Arg Pro Phe His Lys Val Glu Thr Tyr Leu Arg Arg Gln Gln Asn
65 70 75 80

Glu Gln Gly Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Glu Leu Ser
85 90 95

Thr Ser Val Glu Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Thr Pro
100 105 110

Glu Asp Pro Ala Leu Ile Arg Ala Lys Asp Phe Ile Leu Ser Gln Gly
115 120 125

Gly Ile Ser Lys Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile
130 135 140

Gly Cys Tyr Asp Trp Lys Gly Ile Pro Ser Ile Pro Pro Trp Ile Met
145 150 155 160

Leu Phe Pro Asp Asn Phe Pro Phe Thr Ile Tyr Glu Met Ser Ser Trp
165 170 175

Ala Arg Glu Ser Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys Pro
180 185 190

Ile Phe Glu Ile Glu Pro Ala Phe Asn Leu Asp Glu Leu Tyr Ala Glu
195 200 205

Gly Val Glu Asn Val Lys Tyr Ala Leu Pro Arg Asn His Asn Trp Ser
210 215 220

Asp Ile Phe Leu Gly Leu Asp Lys Leu Phe Lys Trp Thr Glu Lys Asn
225 230 235 240

Asn Leu Val Pro Phe His Lys Lys Ser Leu Gln Ala Ala Glu Arg Trp
245 250 255

Met Leu Asn His Gln Gln Glu Ser Gly Asp Trp Gly Gly Ile Met Pro
260 265 270

Pro Met Val Asn Ser Leu Ile Ala Phe Lys Val Leu Asn Tyr Asp Val
275 280 285

Ala Asp Pro Ser Val Gln Arg Gly Phe Glu Ala Ile Asp Arg Phe Ser
290 295 300

Ile Glu Glu Glu Asp Thr Tyr Arg Val Gln Ala Cys Val Ser Pro Val
305 310 315 320

Trp Asp Thr Ala Trp Val Ile Arg Ala Leu Val Asp Ser Gly Leu Lys
325 330 335

Pro Asp His Pro Ser Leu Val Lys Ala Gly Glu Trp Leu Leu Asp Lys
340 345 350

Gln Ile Leu Glu Tyr Gly Asp Trp Ala Ile Lys Asn Lys Gln Gly Lys
355 360 365

Pro Gly Gly Trp Ala Phe Glu Phe Ile Asn Arg Phe Tyr Pro Asp Leu
370 375 380

Asp Asp Ser Ala Val Val Val Met Ala Leu Asn Gly Ile Lys Leu Pro
385 390 395 400

Asp Glu Asn Cys Lys Lys Ala Ala Ile Asn Arg Cys Leu Glu Trp Met
405 410 415

Ala Thr Met Gln Cys Lys Pro Gly Gly Trp Ala Ala Phe Asp Val Asp
420 425 430

Asn Asp Gln Ala Trp Ile Asn Glu Ile Pro Tyr Gly Asp Leu Lys Ala
435 440 445

Met Ile Asp Pro Asn Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met
450 455 460

Val Gly Ser Cys Gly Leu Lys Met Asp Glu Asn Arg Val Gln Lys Ala
465 470 475 480

Leu Phe Tyr Leu Glu Lys Glu Gln Glu Ser Asp Gly Ser Trp Phe Gly
485 490 495

Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala
500 505 510

Leu Ala Val Ile Ala Pro Asn Thr His Lys Pro Gln Met Glu Lys Ala
515 520 525

Val Asn Trp Leu Ile Ser Cys Gln Asn Glu Asp Gly Gly Trp Gly Glu
530 535 540

Thr Cys Trp Ser Tyr Asn Asp Pro Ser Leu Lys Gly Thr Gly Val Ser
545 550 555 560

Thr Ala Ser Gln Thr Ala Trp Ala Leu Ile Gly Leu Leu Asp Ala Gly
565 570 575

Glu Ala Leu Glu Thr Leu Ala Thr Asp Ala Ile Lys Arg Gly Ile Asn
580 585 590

Tyr Leu Leu Asp Thr Gln Thr Pro Asp Gly Thr Trp Glu Glu Ala Glu
595 600 605

Phe Thr Gly Thr Gly Phe Pro Cys His Phe Tyr Ile Arg Tyr His Leu
610 615 620

Tyr Arg His Tyr Phe Pro Leu Ile Ala Leu Gly Arg Tyr Trp Lys Ile
625 630 635 640

Gly Leu Lys Asn Leu Lys Gly
645


<210> 122
<211> 643
<212> PRT
<213> Cyanothece sp.

<400> 122
Met Gln Ile Gln Ala Arg Asn Ile Ser Thr Lys Val Thr Glu Val Phe
1 5 10 15

Ser Lys Val Lys Glu Ala Ile Ala Ala Ser Gln Gln Tyr Leu Leu Ser
20 25 30

Ile Gln Tyr Pro Glu Gly Tyr Trp Trp Ala Glu Leu Glu Ser Asn Val
35 40 45

Thr Ile Thr Ala Glu Ala Val Leu Leu His Lys Ile Trp Gly Thr Asp
50 55 60

Thr Thr Arg Pro Leu His Lys Val Glu Thr Tyr Leu Arg Arg Gln Gln
65 70 75 80

Arg Glu His Gly Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Asp Leu
85 90 95

Ser Thr Ser Val Glu Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Ser
100 105 110

Ala Ser Asp Pro Ala Leu Val Arg Ala Lys Ala Phe Ile Leu Ser Arg
115 120 125

Gly Gly Ile Ser Lys Ser Arg Ile Phe Thr Lys Met His Leu Ala Leu
130 135 140

Ile Gly Cys Tyr Asp Trp Arg Gly Val Pro Ser Ile Pro Pro Trp Ile
145 150 155 160

Met Leu Leu Pro Glu Asn Phe Pro Phe Thr Ile Tyr Glu Met Ser Ser
165 170 175

Trp Ala Arg Gly Ser Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys
180 185 190

Pro Val Tyr Gln Cys Gly Ile Thr Leu Asp Glu Leu Tyr Ser Glu Gly
195 200 205

Ile Asn His Val Arg Tyr Asp Leu Pro Arg Asn Gly Asp Trp Thr Asp
210 215 220

Val Phe Val Trp Leu Asp Gly Val Phe Lys Phe Ala Glu Thr Asn Asn
225 230 235 240

Leu Ile Pro Phe Arg Asn Glu Ser Leu Lys Ala Ala Glu Arg Trp Val
245 250 255

Leu Glu Arg Gln Glu Asp Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala
260 265 270

Met Leu Asn Ser Leu Leu Ala Leu Arg Ala Leu Asp Tyr Glu Val Asn
275 280 285

Asp Pro Ile Val His Arg Gly Phe Lys Ser Val Asp Asn Phe Ala Ile
290 295 300

Glu Thr Glu Glu Thr Tyr His Val Gln Pro Cys Ile Ser Pro Val Trp
305 310 315 320

Asp Thr Ala Trp Val Leu Arg Ala Leu Val Glu Ser Gly Leu Lys Pro
325 330 335

Asp Glu Pro Val Leu Val Lys Gly Ala Gln Trp Leu Leu Asp Lys Gln
340 345 350

Ile Leu Asp Tyr Gly Asp Trp Ala Val Lys Asn Lys Glu Gly Thr Pro
355 360 365

Gly Gly Trp Ala Phe Glu Phe Asp Asn Arg Trp Tyr Pro Asp Leu Asp
370 375 380

Asp Ser Ala Val Val Val Met Ala Leu Glu Gln Val Lys Met Pro Asp
385 390 395 400

Glu Gln Leu Lys Tyr Gly Ala Met Arg Arg Cys Val Arg Trp Met Ala
405 410 415

Thr Met Gln Cys Lys Ala Gly Gly Trp Gly Ala Phe Asp Val Asn Asn
420 425 430

Asp Gln Asn Trp Leu Asn Tyr Leu Pro Tyr Ala Asp Leu Lys Ala Met
435 440 445

Ile Asp Pro Asn Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met Leu
450 455 460

Gly Thr Cys Glu Leu Ser Met Asp His Asp Arg Val Lys Arg Ala Ile
465 470 475 480

Ala Tyr Leu Glu Gln Glu Gln Glu Ala Asp Gly Ser Trp Phe Gly Arg
485 490 495

Trp Gly Val Asn Tyr Ile Tyr Gly Thr Ser Gly Ala Leu Ser Ala Leu
500 505 510

Ala Ala Ile Ala Pro Val Thr His Gln Ala Gln Ile Glu Lys Gly Ala
515 520 525

Ala Trp Leu Val Gly Cys Gln Asn Pro Asp Gly Gly Trp Gly Glu Thr
530 535 540

Cys Phe Ser Tyr Asn Asn Pro Ala Leu Arg Gly Lys Gly Asp Ser Thr
545 550 555 560

Ala Ser Gln Thr Ala Trp Gly Leu Ile Gly Leu Leu Ala Ala Gly Glu
565 570 575

Ala Thr Gly Lys Phe Ala Lys Thr Ala Leu Glu Arg Gly Val Asn Tyr
580 585 590

Leu Leu Ala Thr Gln Arg Pro Asp Gly Thr Trp Asp Glu Ser Tyr Phe
595 600 605

Thr Gly Thr Gly Phe Pro Cys His Phe Tyr Leu Lys Tyr His Leu Tyr
610 615 620

Leu Gln Tyr Phe Pro Leu Ile Ala Leu Ser Arg Tyr Gln Arg Leu Leu
625 630 635 640

Gly Phe Asn


<210> 123
<211> 640
<212> PRT
<213> Cyanothece sp.

<400> 123
Met Gln Thr Arg Asp Arg Gln Thr His Lys Pro Ala Leu Ser Leu Asn
1 5 10 15

Asp Ala Ile Thr Ala Ser Gln Asn Tyr Leu Leu Ser Leu Gln Tyr Pro
20 25 30

Gln Gly Tyr Trp Trp Ala Glu Leu Glu Ser Asn Ile Thr Leu Thr Ala
35 40 45

Glu Thr Val Leu Leu His Lys Ile Trp Gly Thr Asp Lys Thr Arg Pro
50 55 60

Leu His Lys Val Glu Ala Tyr Leu Arg Gln Gln Gln Arg Glu His Gly
65 70 75 80

Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Glu Ile Ser Thr Ser Val
85 90 95

Glu Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Pro Ser Asn Asp Pro
100 105 110

Ala Leu Ile Arg Ala Lys Asn Phe Ile Ile Ser Gln Gly Gly Ile Ser
115 120 125

Lys Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile Gly Cys Tyr
130 135 140

Ser Trp Lys Gly Ile Pro Ser Ile Pro Pro Trp Ile Met Leu Phe Pro
145 150 155 160

Asn Ser Phe Pro Phe Thr Ile Tyr Glu Met Ala Ser Trp Ala Arg Glu
165 170 175

Ser Thr Val Pro Leu Ile Ile Val Phe Asn Asp Lys Pro Val Phe Ala
180 185 190

Ile Asp Pro Ile Phe Asn Leu Asp Glu Leu Tyr Ala Glu Gly Ile Glu
195 200 205

Asn Val Lys Tyr Glu Leu Pro Lys Asn Asn Asn Trp Gly Asp Leu Phe
210 215 220

Leu Gly Leu Asp Lys Val Phe Lys Leu Ala Glu Gln Val Asp Leu Val
225 230 235 240

Pro Phe Arg Lys Gln Gly Leu Gln Ala Ala Glu Arg Trp Met Leu Asp
245 250 255

His Gln Gln Glu Thr Gly Asp Trp Gly Gly Ile Met Pro Pro Met Val
260 265 270

Asn Ser Leu Leu Ala Phe Arg Val Leu Asn Tyr Asp Val Ala Asp Pro
275 280 285

Ser Val Gln Arg Gly Phe Glu Ala Ile Asp Arg Phe Ser Ile Glu Glu
290 295 300

Asn Asp Thr Tyr Arg Val Gln Ala Cys Val Ser Pro Val Trp Asp Thr
305 310 315 320

Ala Trp Cys Ile Arg Ala Leu Thr Asp Ser Gly Leu Pro Lys Asp His
325 330 335

Phe Ser Leu Val Lys Ala Gly Lys Trp Leu Leu Glu Lys Gln Val Leu
340 345 350

Glu Tyr Gly Asp Trp Ala Val Lys Asn Lys Thr Gly Lys Pro Gly Gly
355 360 365

Trp Ala Phe Glu Phe Thr Asn Arg Phe Tyr Pro Asp Ile Asp Asp Ser
370 375 380

Ala Thr Val Val Met Ala Leu Asn Gly Ile Lys Leu Pro Asp Glu Ala
385 390 395 400

Leu Lys Gln Ala Ala Ile Asn Arg Cys Leu Lys Trp Ile Glu Thr Met
405 410 415

Gln Cys Lys Ala Gly Gly Trp Ala Ala Phe Asp Val Asp Asn Asp Gln
420 425 430

Ala Trp Leu Asn Glu Ile Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp
435 440 445

Pro Asn Thr Ala Asp Val Thr Ala Arg Val Val Glu Met Val Gly Ser
450 455 460

Cys Asp Leu Glu Met Ser Ser Asp Arg Leu Asn Lys Ala Leu Asp Tyr
465 470 475 480

Leu Tyr Glu Glu Gln Glu Lys Asp Gly Ser Trp Phe Gly Arg Trp Gly
485 490 495

Val Asn Tyr Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala Leu Ala Val
500 505 510

Ile Asn Pro Lys Gln His Lys Ser Gln Ile Glu Gln Gly Met Asn Trp
515 520 525

Leu Leu Ser Cys Gln Asn Glu Asp Gly Gly Trp Gly Glu Thr Cys Trp
530 535 540

Ser Tyr Asn Asp Leu Ser Leu Lys Gly Lys Gly Val Ser Thr Pro Ser
545 550 555 560

Gln Thr Ala Trp Ala Leu Ile Gly Leu Leu Asp Ala Gly Glu Val Leu
565 570 575

Asn His Phe Glu Thr Asp Ser Ile Glu Arg Gly Ile Asn Tyr Leu Leu
580 585 590

Asn Thr Gln Thr Glu Glu Gly Thr Trp Glu Glu Ser Glu Phe Thr Gly
595 600 605

Thr Gly Phe Pro Cys His Phe Tyr Ile Arg Tyr His Phe Tyr Arg His
610 615 620

Tyr Phe Pro Leu Ile Ala Leu Gly Arg Tyr Gln Gln Met Leu Gly Ser
625 630 635 640




<210> 124
<211> 668
<212> PRT
<213> Cyanothece sp.

<400> 124
Met Gln Ile Arg Ala Thr Val Asp Thr Ala Lys Leu Glu Lys Ala Ile
1 5 10 15

Ala Ala Ser Gln Glu His Leu Leu Ser Thr Gln Tyr Pro Glu Gly Tyr
20 25 30

Trp Trp Ala Glu Leu Glu Ser Asn Val Thr Met Thr Ala Glu Val Val
35 40 45

Leu Leu His Lys Ile Trp Lys Thr Asp Gly Thr Arg Pro Met His Lys
50 55 60

Ala Glu Lys Tyr Leu Arg Ser Glu Gln Arg Glu His Gly Gly Trp Glu
65 70 75 80

Leu Phe Tyr Gly Asp Gly Gly Asp Leu Ser Thr Ser Val Glu Thr Tyr
85 90 95

Thr Ala Leu Arg Leu Leu Gly Val Pro Ala Ser Asp Pro Ala Leu Leu
100 105 110

Lys Ala Lys Asp Phe Ile Leu Arg Arg Gly Gly Ile Ser Lys Thr Arg
115 120 125

Ile Phe Thr Lys Leu His Leu Ala Leu Ile Gly Cys Tyr Asp Trp Arg
130 135 140

Gly Leu Pro Ser Leu Pro Pro Trp Val Met Leu Leu Pro Glu Asn Phe
145 150 155 160

Pro Phe Thr Ile Tyr Glu Leu Ser Ser Trp Ala Arg Gly Ser Thr Val
165 170 175

Pro Leu Leu Ile Val Met Asp Arg Lys Pro Val Phe Ser Val Asn Pro
180 185 190

Gln Ile Asn Val Asp Glu Leu Tyr Ala Glu Gly Arg Asp Arg Val Lys
195 200 205

Phe Glu Leu Pro Arg Lys Gly Asp Trp Thr Asp Leu Phe Ile Glu Leu
210 215 220

Asp Gly Leu Phe Lys Phe Thr Glu Gln Asn Asn Leu Val Pro Phe Arg
225 230 235 240

Glu Glu Gly Leu Arg Ala Ala Glu Arg Trp Val Leu Glu Arg Gln Glu
245 250 255

Ala Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn Ser Leu
260 265 270

Leu Ala Leu Arg Ala Leu Gly Tyr His Pro Ala Asp Pro Tyr Val Arg
275 280 285

Arg Gly Met Ala Ala Val Asp Arg Phe Ala Ile Glu Thr Ala Asp Thr
290 295 300

Tyr Arg Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Leu Val
305 310 315 320

Met Arg Gly Leu Ile Asp Ser Gly Leu Pro Ala Asp His Pro Ala Ile
325 330 335

Val Lys Ala Gly Glu Trp Leu Leu Glu Lys Gln Ile Leu Ala Tyr Gly
340 345 350

Asp Trp Ala Val Lys Asn Lys Thr Gly Gln Pro Gly Ala Trp Ala Phe
355 360 365

Glu Phe Glu Asn Arg Phe Tyr Pro Asp Val Asp Asp Ser Ala Val Val
370 375 380

Val Met Ala Leu Gln Ala Ala Gln Leu Pro Asp Glu Asp Leu Lys Gln
385 390 395 400

Gln Ala Ile Glu Arg Cys Val Lys Trp Ile Ala Thr Met Gln Cys Lys
405 410 415

Pro Gly Gly Trp Ala Ala Phe Asp Val Asp Asn Asp Gln Asp Trp Leu
420 425 430

Asn Gln Ile Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp Pro Asn Thr
435 440 445

Ala Asp Val Thr Ala Arg Val Leu Glu Met Ile Gly Arg Ser Gly Val
450 455 460

Thr Thr Gly Glu Ala Ser Val Glu Arg Ala Leu Ala Tyr Leu Arg Arg
465 470 475 480

Glu Gln Glu Val Glu Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr
485 490 495

Ile Tyr Gly Thr Ser Gly Val Leu Ala Ala Leu Ala Leu Ile Ala Pro
500 505 510

Lys Ser Asp His Ala Met Ile Gln Arg Gly Ala Asp Trp Leu Val Arg
515 520 525

Cys Gln Asn Ala Asp Gly Gly Trp Gly Glu Thr Cys Arg Ser Tyr Asn
530 535 540

Asp Pro His Leu Lys Gly Gln Gly Pro Ser Thr Ala Ser Gln Thr Ala
545 550 555 560

Trp Ala Leu Ile Gly Leu Leu Ala Ala Gly Glu Ala Thr Gly Glu Phe
565 570 575

Ala Trp Gly Ala Ile Asp Arg Gly Ile Asn Tyr Leu Leu Ala Thr Gln
580 585 590

Gln Gln Asp Gly Arg Trp Asp Glu Asp Trp Phe Thr Gly Thr Gly Phe
595 600 605

Pro Gly His Phe Tyr Leu Lys Tyr His Leu Tyr Gln Gln His Phe Pro
610 615 620

Leu Thr Ala Leu Gly Arg Tyr Ser Ser Leu Thr Gly Leu Lys Gln Glu
625 630 635 640

Leu Lys Ile Pro Leu Gln Leu Lys Ser Lys Pro Glu Val Val Met Ile
645 650 655

Glu Asp Ser Asp Leu Leu Ser Asp Glu Asp Ala Thr
660 665


<210> 125
<211> 651
<212> PRT
<213> Cyanothece sp. PCC 8802

<400> 125
Met Gln Thr Gln Asn Arg Val Thr Ser Thr Gln Lys Val Glu Leu Ser
1 5 10 15

Asn Leu Thr Gln Ala Ile Ile Ala Ser Gln Asn Tyr Ile Leu Ser Arg
20 25 30

Gln Tyr Pro Glu Gly Tyr Trp Trp Gly Glu Leu Glu Ser Asn Ile Thr
35 40 45

Leu Thr Ala Glu Thr Val Leu Leu His Lys Ile Trp Lys Thr Asp Lys
50 55 60

Thr Arg Pro Phe His Lys Val Glu Thr Tyr Leu Arg Arg Gln Gln Asn
65 70 75 80

Glu Gln Gly Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Glu Leu Ser
85 90 95

Thr Ser Val Glu Ala Tyr Met Ala Leu Arg Leu Leu Gly Val Thr Pro
100 105 110

Glu Asp Pro Ala Leu Ile Arg Ala Lys Asp Phe Ile Leu Ser Lys Gly
115 120 125

Gly Ile Ser Lys Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile
130 135 140

Gly Cys Tyr Asp Trp Lys Gly Ile Pro Ser Ile Pro Pro Trp Ile Met
145 150 155 160

Leu Phe Pro Asp Asn Phe Pro Phe Thr Ile Tyr Glu Met Ser Ser Trp
165 170 175

Ala Arg Glu Ser Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys Pro
180 185 190

Ile Phe Glu Ile Glu Pro Ala Phe Asn Leu Asp Glu Leu Tyr Ala Glu
195 200 205

Gly Val Glu Asn Val Lys Tyr Ala Leu Pro Arg Asn His Asn Trp Ser
210 215 220

Asp Ile Phe Leu Gly Leu Asp Lys Leu Phe Lys Trp Thr Glu Lys Asn
225 230 235 240

Asn Leu Val Pro Phe His Lys Lys Ser Leu Gln Ala Ala Glu Lys Trp
245 250 255

Met Leu Asn His Gln Gln Glu Ser Gly Asp Trp Gly Gly Ile Met Pro
260 265 270

Pro Met Val Asn Ser Leu Ile Ala Phe Lys Val Leu Asn Tyr Asp Val
275 280 285

Ala Asp Pro Ser Val Gln Arg Gly Phe Glu Ala Ile Asp Arg Phe Ser
290 295 300

Ile Glu Glu Glu Asp Thr Tyr Arg Val Gln Ala Cys Val Ser Pro Val
305 310 315 320

Trp Asp Thr Ala Trp Val Ile Arg Ala Leu Val Asp Ser Gly Leu Lys
325 330 335

Pro Asp His Pro Ser Leu Val Lys Ala Gly Glu Trp Leu Leu Asp Lys
340 345 350

Gln Ile Leu Glu Tyr Gly Asp Trp Ala Ile Lys Asn Lys Gln Gly Lys
355 360 365

Pro Gly Gly Trp Ala Phe Glu Phe Ile Asn Arg Phe Tyr Pro Asp Leu
370 375 380

Asp Asp Ser Ala Val Val Val Met Ala Leu Asn Gly Ile Lys Leu Pro
385 390 395 400

Asp Glu Asn Arg Lys Lys Ala Ala Ile Asn Arg Cys Leu Glu Trp Met
405 410 415

Ala Thr Met Gln Cys Lys Pro Gly Gly Trp Ala Ala Phe Asp Val Asp
420 425 430

Asn Asp Gln Ala Trp Ile Asn Glu Ile Pro Tyr Gly Asp Leu Lys Ala
435 440 445

Met Ile Asp Pro Asn Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met
450 455 460

Val Gly Ser Cys Gly Leu Lys Met Asp Glu Asn Arg Val Gln Lys Ala
465 470 475 480

Leu Phe Tyr Leu Glu Lys Glu Gln Glu Ser Asp Gly Ser Trp Phe Gly
485 490 495

Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala
500 505 510

Leu Ala Val Ile Ala Pro Asn Thr His Lys Pro Gln Met Glu Lys Ala
515 520 525

Val Asn Trp Leu Ile Ser Cys Gln Asn Glu Asp Gly Gly Trp Gly Glu
530 535 540

Thr Cys Trp Ser Tyr Asn Asp Ser Ser Leu Lys Gly Thr Gly Ile Ser
545 550 555 560

Thr Ala Ser Gln Thr Ala Trp Ala Ile Ile Gly Leu Leu Asp Ala Gly
565 570 575

Glu Ala Leu Glu Thr Leu Ala Thr Asp Ala Ile Lys Arg Gly Ile Asp
580 585 590

Tyr Leu Leu Ala Thr Gln Thr Pro Asp Gly Thr Trp Glu Glu Ala Glu
595 600 605

Phe Thr Gly Thr Gly Phe Pro Cys His Phe Tyr Ile Arg Tyr His Leu
610 615 620

Tyr Arg His Tyr Phe Pro Leu Ile Ala Leu Gly Arg Tyr Trp Lys Ile
625 630 635 640

Gly Leu Lys Thr Pro Ser Val Ile Pro Leu Asn
645 650


<210> 126
<211> 705
<212> PRT
<213> Desulfovibrio salexigens

<400> 126
Met Asn Lys Lys Ser Ala Met Lys Leu Lys Lys Lys Ala Lys Asn His
1 5 10 15

Val Val Ser Leu Leu Gln Pro Thr Asp Ala Leu Asn Arg Val Met Lys
20 25 30

Arg Phe Arg Ser Leu Gln Ser Pro Glu Gly Tyr Trp Val Phe Ala Leu
35 40 45

Glu Ala Asp Val Thr Ile Pro Ser Glu Tyr Ile Met Phe Asn Arg Phe
50 55 60

Leu Gly Arg Lys Met Asp Lys Gly Leu Ala Glu Arg Leu Gly Asn Tyr
65 70 75 80

Ile Arg Ala Lys Gln Met Ala Asp Gly Gly Trp Pro Leu His Asp Asn
85 90 95

Asp Gly Pro Val Asn Ile Ser Ala Ser Val Lys Ala Tyr Met Ala Leu
100 105 110

Lys Met Leu Gly Asp Asn Lys Asp Ala Glu His Met Val Arg Ala Arg
115 120 125

Gln Ile Ile Leu Ala Lys Gly Gly Ala Glu Thr Ala Asn Val Phe Thr
130 135 140

Arg Ile Cys Leu Ala Thr Phe Gly Gln Ile Pro Trp His Cys Pro Pro
145 150 155 160

Ala Met Pro Ile Glu Ile Val Leu Leu Pro Lys Trp Phe Phe Phe His
165 170 175

Leu Asp Lys Val Ser Tyr Trp Ser Arg Ser Val Ile Tyr Pro Leu Leu
180 185 190

Ile Ile Tyr Ala Lys Gln Pro Val Cys Arg Leu Arg Pro Glu Glu Ala
195 200 205

Val Pro Glu Leu Phe Cys Lys Pro Ala Glu Glu His Ile His Ile Asp
210 215 220

Lys Tyr Arg Asp Lys Gly Trp Arg Lys Asn Leu Phe Ile Leu Leu Asp
225 230 235 240

Arg Val Leu Lys Arg Thr Ile His Leu Val Pro Lys Ser Ile Asn Lys
245 250 255

Lys Ala Leu Asn Tyr Ala Glu Lys Trp Thr Arg Glu His Met Ala Gly
260 265 270

Arg Gly Gly Ile Gly Ala Ile Phe Pro Ala Met Ala Asn Ala Val Met
275 280 285

Ala Leu Ser Leu Leu Gly Tyr Asp Glu Ser Asp Pro Asp Phe Ala Arg
290 295 300

Gly Met Gln Ser Val Asp Asp Leu Met Val Asp Lys Phe His Val Pro
305 310 315 320

Glu Lys Ser Pro Trp Glu His Thr Val Ile Thr Gly Gly Ala Glu Leu
325 330 335

Ser Ala Ala Pro Glu Leu Asp Ile Ser Pro Asp His Gly Thr Ala Glu
340 345 350

Asn Leu Glu Gln Ala Met Cys Gln Pro Cys Asn Ser Pro Ile Trp Asp
355 360 365

Thr Cys Leu Thr Leu Ser Ala Met Met Glu Ala Gly Glu Asn Gln Asp
370 375 380

Ser Lys Ser Thr Gln Gln Ala Leu Asn Trp Leu Trp Asp Gln Gln Ile
385 390 395 400

Phe Phe Arg Gly Asp Trp Ile Ser Lys Ala Pro Lys Leu Glu Gly Gly
405 410 415

Gly Trp Ala Phe Gln Phe Glu Asn Thr Phe Tyr Pro Asp Leu Asp Asp
420 425 430

Thr Ala Met Val Leu Met Ala Met Cys Arg Ala Gly Val Leu Asp Gln
435 440 445

Pro Glu His Arg Glu Asn Phe Ile Lys Gly Val Asn Trp Leu Ile Gly
450 455 460

Met Gln Ser Ser Asn Gly Gly Trp Ala Ala Phe Asp Ile Asp Asn Cys
465 470 475 480

Ala Glu Tyr Leu Asn Asp Ile Pro Phe Ala Asp His Gly Ala Leu Leu
485 490 495

Asp Pro Pro Thr Ser Asp Leu Thr Ala Arg Val Ile Glu Leu Leu Gly
500 505 510

Val Leu Gly Tyr Asp Lys Ser Phe Arg Pro Ile Lys Asp Gly Ile Glu
515 520 525

Phe Leu Lys Lys Glu Gln Glu Asp Asp Gly Ser Trp Phe Gly Arg Trp
530 535 540

Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Gly Leu Arg
545 550 555 560

Gln Ala Gly Glu Asp Met Asn Ser Ser Tyr Val Cys Lys Ala Val Glu
565 570 575

Trp Phe Glu Asn His Gln Asn Lys Asp Gly Gly Trp Gly Glu Ser Cys
580 585 590

Leu Ser Tyr Asn Asp Lys Asn Tyr Ala Gly Leu Gly Asp Ser Thr Ala
595 600 605

Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala Gly Arg Val
610 615 620

His Ser Lys Ala Val Ser Arg Gly Val Arg Tyr Leu Leu Asp Thr Gln
625 630 635 640

Lys Asp Asp Gly Ser Trp Asp Glu Ser Leu Phe Thr Gly Thr Gly Phe
645 650 655

Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Ser Gln Tyr Phe Pro
660 665 670

Met Trp Ala Leu Gly Val Tyr Gln Arg Phe Ser Ala Asp Glu Asp Thr
675 680 685

Lys Gln Ile Met Met Arg Arg Lys Ser Pro Leu Asp Leu Gly Arg Lys
690 695 700

Trp
705


<210> 127
<211> 685
<212> PRT
<213> Dryopteris crassirhizoma

<220>
<221> misc_feature
<222> (145)..(145)
<223> Xaa can be any amino acid


<400> 127
Met Leu Pro Tyr Asn Gln Asp Phe Tyr Asn Glu Asp Glu Ala Leu Lys
1 5 10 15

Asp Asp His Cys Glu Gly Ala Gly Asn Val Ser Asn Pro Pro Thr Leu
20 25 30

Asp Glu Ala Ile Lys Arg Ser Gln Asp Phe Leu Leu Ser Gln Gln Tyr
35 40 45

Pro Glu Gly Tyr Trp Trp Ala Glu Leu Glu Gly Asn Pro Thr Ile Thr
50 55 60

Ser His Thr Val Ile Leu Tyr Lys Ile Leu Gly Ile Glu Asp Glu Tyr
65 70 75 80

Pro Met Asp Lys Met Glu Lys Tyr Leu Arg Arg Met Gln Cys Ile His
85 90 95

Gly Gly Trp Glu Leu Phe Tyr Gly Asp Gly Gly Gln Leu Ser Val Thr
100 105 110

Ile Glu Ser Tyr Val Ala Leu Arg Leu Leu Asn Val Pro Pro Thr Asp
115 120 125

Pro Ala Leu Lys Lys Ala Leu Lys Phe Ile Ile Asp Lys Gly Gly Val
130 135 140

Xaa Lys Ser Arg Met Phe Thr Lys Ile Cys Leu Ala Leu Leu Gly Cys
145 150 155 160

Phe Asp Trp Arg Gly Ile Pro Ser Leu Pro Pro Trp Val Met Leu Leu
165 170 175

Pro Gly Trp Phe Leu Ser Ser Ile Tyr Glu Thr Ala Cys Trp Ala Arg
180 185 190

Gly Cys Val Val Pro Leu Ile Val Val Phe Asp Lys Lys Pro Val Phe
195 200 205

Lys Val Ser Pro Glu Val Ser Phe Asp Glu Leu Tyr Ala Glu Gly Arg
210 215 220

Glu His Ala Cys Lys Thr Leu Pro Phe Cys Gly Asp Trp Thr Ser His
225 230 235 240

Phe Phe Ile Ala Val Asp Arg Val Phe Lys Met Met Glu Arg Leu Gly
245 250 255

Val Val Pro Phe Gln Gln Trp Gly Ile Arg Glu Ala Glu Lys Trp Leu
260 265 270

Leu Glu Arg Gln Glu Asp Thr Gly Asp Phe Leu Gly Val Tyr Pro Pro
275 280 285

Met Phe Tyr Ser Val Val Cys Met Lys Thr Leu Gly Tyr Glu Val Thr
290 295 300

Asp Pro Val Val Arg Arg Ala Leu Leu Ser Phe Lys Lys Phe Ser Ile
305 310 315 320

Glu Arg Ala Asp Glu Cys Ser Val Gln Ser Ser Leu Ser Pro Val Trp
325 330 335

Asp Thr Ala Leu Val Val Arg Ser Leu Val Glu Ser Gly Leu Pro Pro
340 345 350

Asp His Pro Ala Leu Gln Arg Ala Gly Glu Trp Leu Leu Gln Lys Gln
355 360 365

Ile Thr Lys His Gly Asp Trp Ser Phe Lys Asn Gln Ser Gly Val Ala
370 375 380

Gly Gly Trp Ala Phe Gln Phe Phe Asn Arg Trp Tyr Pro Asp Leu Asp
385 390 395 400

Asp Ser Ala Val Val Val Met Ala Leu Asp Cys Leu Lys Leu Pro Asn
405 410 415

Glu Asp Val Lys Asn Gly Ala Ile Thr Arg Cys Leu Lys Trp Ile Ser
420 425 430

Ser Met Gln Cys Lys Gly Gly Gly Trp Ala Ala Phe Asp Lys Asp Asn
435 440 445

His Gln His Trp Ile Asn Ser Thr Pro Phe Ser Asp Leu Lys Ala Met
450 455 460

Val Asp Pro Ser Thr Thr Asp Ile Ser Ala Arg Val Leu Glu Met Val
465 470 475 480

Gly Arg Leu Lys Leu His Gly Thr Ser Phe Asp Glu Ala His Phe Leu
485 490 495

Pro Pro Glu Ser Ile Ala Arg Gly Leu Val Tyr Leu Arg Arg Glu Gln
500 505 510

Glu Asn Glu Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr
515 520 525

Gly Thr Cys Gly Ala Leu Val Ala Leu Ser Leu Val Ala Pro Met Thr
530 535 540

His Glu Glu Glu Ile Ala Arg Gly Ala Arg Trp Leu Val Gln Val Gln
545 550 555 560

Asn Met His Gly Lys Lys Ile Asn Gly Pro Gln Asp Gly Gly Trp Gly
565 570 575

Glu Thr Cys Phe Ser Tyr Asn Asp Pro Ala Leu Lys Gly Gln Gly Asp
580 585 590

Val Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Gln Gly Leu Leu Ala
595 600 605

Ala Gly Asp Ala Leu Gly Lys Tyr Glu Val Glu Ser Ile Gly His Gly
610 615 620

Val Gln Tyr Leu Leu Ser Thr Gln Arg Lys Asp Gly Ser Trp His Glu
625 630 635 640

Ser Gln Phe Thr Gly Gly Gly Phe Pro Ile His Phe Tyr Leu Arg Tyr
645 650 655

His Phe Tyr Ala Gln His Phe Thr Leu Ser Ser Leu Ala Arg Tyr Arg
660 665 670

Thr Arg Leu Gln Ala Ser Lys Ile Lys Pro Pro Ile Pro
675 680 685


<210> 128
<211> 747
<212> PRT
<213> Frankia alni

<400> 128
Met Pro Asp Leu Glu Leu Arg Asp Val Asp Arg Ala Asp Gly Arg His
1 5 10 15

His Ala Pro Asn Leu Gly Arg Thr Asp Thr Leu Ser Pro Ser Ala Pro
20 25 30

Thr Gly Glu Pro Ala Pro Ala Ser Thr Pro Ala Ala Val Ala Thr Pro
35 40 45

Thr Pro Thr Pro Thr Thr Ala Pro Ala Pro Ala Pro Ala Pro Glu Asn
50 55 60

Ala Leu Arg Glu Thr Val Gln Arg Ala Ala Glu His Leu Leu Arg Leu
65 70 75 80

Gln Asp Pro Arg Gly Trp Trp Lys Phe Asp Leu Glu Thr Asn Pro Thr
85 90 95

Met Asp Ala Glu Asp Leu Leu Leu Arg Glu Tyr Leu Gly Ile Arg Thr
100 105 110

Val Glu Gln Thr Glu Ala Thr Ala Lys His Ile Arg Ser Arg Arg Leu
115 120 125

Asp Asp Gly Ser Trp Pro Thr Tyr Phe Gly Gly Pro Gly Glu Leu Ser
130 135 140

Thr Thr Val Glu Cys Tyr Ile Ala Leu Arg Leu Ala Gly Asp Ser Pro
145 150 155 160

Asp Asp Glu Pro Leu Arg Arg Ser Ala Ala Trp Ile Arg Glu Arg Gly
165 170 175

Gly Ile Pro Ala Thr Arg Val Phe Thr Arg Ile Trp Leu Ala Leu Phe
180 185 190

Gly Trp Trp Arg Trp Glu Asp Leu Pro Val Leu Pro Pro Glu Ile Met
195 200 205

Phe Leu Pro Pro Arg Ala Pro Leu Ser Ile Tyr Ser Phe Ala Ser Trp
210 215 220

Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser Ala Ala Arg Pro
225 230 235 240

Gln Cys Pro Ala Pro Phe Asp Leu Ala Glu Leu Asp Pro Asp Glu Val
245 250 255

Pro Ala Ala Gln Ser His Gly Ala Ala Gln Ser Pro Asp Thr Arg Ser
260 265 270

Pro Ala Gly Gly Arg Thr Leu Arg Gly Ala Met Arg Arg Leu Gly Gly
275 280 285

Asp Arg Pro Asn Thr Ala Lys Val Phe Phe Arg Gly Leu Asp Ala Ala
290 295 300

Leu His Arg Tyr His Arg His Pro Ile Gly Pro Leu Arg Arg His Ala
305 310 315 320

Leu Arg Thr Ala Glu Arg Trp Ile Ile Ala Arg Gln Glu Ala Asp Gly
325 330 335

Cys Phe Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Ile Ile Ala Leu
340 345 350

Arg Leu Leu Gly Tyr Asp Leu Asp His Pro Val Leu Ala Ala Ala Leu
355 360 365

Arg Ser Leu Asp Ala Tyr Thr Leu His Arg Glu Asp Gly Ser Arg Met
370 375 380

Ile Glu Ala Ser Gln Ser Pro Ile Trp Asp Thr Ala Leu Ala Val Leu
385 390 395 400

Ala Leu Ala Asp Ala Gly Ile Asp Ala Pro Ala Asp Val Asp Val Ala
405 410 415

Pro Ala Leu Pro Thr Gln Arg Val Ala Thr Gly Ala Pro Ala Pro Ser
420 425 430

Ala Pro Val Pro Thr Ala Leu Glu Arg Ala Ala Asp Trp Leu Leu Gly
435 440 445

Gln Glu Ile Gln His Arg Arg Gly Asp Trp Ala Ile Thr His Pro Gly
450 455 460

Val Ala Pro Gly Gly Trp Ala Phe Glu Phe Asp Asn Asp Thr Tyr Pro
465 470 475 480

Asp Thr Asp Asp Thr Ala Glu Val Val Leu Ala Leu His Arg Leu Asn
485 490 495

Arg Leu Arg Arg Leu Arg His Pro Thr Asn Thr Arg Ile Asp Ala Ala
500 505 510

Leu Glu Arg Ser Thr Ala Trp Leu Phe Ala Leu Gln Ser Arg Asp Gly
515 520 525

Gly Trp Gly Ala Tyr Asp Ser Asp Asn Ala Ser Thr Leu Val Tyr Gln
530 535 540

Ile Pro Phe Ala Asp Phe Gly Ala Leu Thr Asp Pro Ser Ser Ala Asp
545 550 555 560

Val Thr Ala His Val Val Glu Leu Leu Cys Glu Thr Gly Arg Ile Arg
565 570 575

Asp Pro Arg Thr Leu Arg Gly Val Asp Trp Leu Leu Arg Asn Gln Glu
580 585 590

Ala Asp Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly
595 600 605

Thr Gly Ser Val Leu Pro Ala Leu Gln Ala Ala Gly Leu Pro Pro Thr
610 615 620

His Pro Ala Met Val Ala Gly Ala Arg Trp Leu Leu Ser Arg Gln Asn
625 630 635 640

Ser Asp Gly Gly Trp Gly Glu Asp Ile Arg Ser Tyr Gly Asp Pro Ala
645 650 655

Trp Ser Gly Arg Gly Leu Ser Thr Pro Ser Gln Thr Ala Trp Ala Met
660 665 670

Leu Gly Leu Leu Ala Thr Asp His Gly Gly Val His Ala Asp Ala Leu
675 680 685

Ala Ala Ala Ala Arg Trp Leu Thr Glu Gln Gln Arg Pro Asp Gly Gly
690 695 700

Trp Asp Glu Glu Met Phe Thr Gly Thr Gly Phe Pro Gly Phe Phe Tyr
705 710 715 720

Leu Asn Tyr His Gly Tyr Arg Leu Val Trp Pro Val Met Ala Leu Gly
725 730 735

Arg Tyr Leu His Ser Arg Gln His Pro Ser Asp
740 745


<210> 129
<211> 704
<212> PRT
<213> Frankia alni

<400> 129
Met Ser Leu Thr Ser Asp Pro Ser Pro Ala Ala Pro Thr Ala Glu Lys
1 5 10 15

Ser Pro Lys Arg Pro Thr Ile Pro Val Pro Ala Thr Ala Asp Ala Tyr
20 25 30

Gly Ile Ser Arg Ser Ser Pro Pro Leu Pro Ala Ala Thr Gly Arg Pro
35 40 45

Gln Ala Ala Gly Pro Ala Ser Ala Gly Val Ala Thr Ala Arg Ala Arg
50 55 60

Asp His Leu Leu Ala Leu Gln Ser Glu Glu Gly Trp Trp Lys Gly Asp
65 70 75 80

Leu Glu Thr Asn Val Thr Met Asp Ala Glu Asp Leu Phe Met Lys Gln
85 90 95

Phe Leu Gly Ile Arg Gly Asp Asp Glu Thr Glu Gln Thr Ala Arg Trp
100 105 110

Ile Arg Ser Gln Gln Leu Ala Asp Gly Gly Trp Pro Thr Phe Tyr Gly
115 120 125

Gly Pro Ala Asp Leu Ser Thr Thr Ile Glu Ala Tyr Ile Ala Leu Arg
130 135 140

Leu Ala Gly Asp Ala Val Asp Ala Pro His Met Ala Arg Ala Ala Glu
145 150 155 160

Leu Val Arg Ala Gln Gly Gly Val Ala Ala Ser Arg Val Phe Thr Arg
165 170 175

Ile Trp Leu Ala Ala Leu Gly Gln Trp Ser Trp Asp Asp Val Pro Val
180 185 190

Ile Pro Pro Glu Leu Ile Phe Leu Pro Ser Trp Ile Pro Leu Asn Val
195 200 205

Tyr Asp Phe Ala Cys Trp Ala Arg Gln Thr Ile Val Ala Leu Thr Ile
210 215 220

Val Gly Ser Leu Arg Pro Ser His Asp Leu Gly Phe Ser Ile Asp Glu
225 230 235 240

Leu Lys Val Pro Ala Ala Ala Arg Lys Pro Ala Ala Leu Arg Ser Trp
245 250 255

Glu Gly Ala Phe Glu Arg Leu Asp Lys Leu Leu His Arg Tyr Glu Lys
260 265 270

Arg Pro Ile Lys Leu Leu Arg Thr Leu Ala Leu Arg Arg Ala Thr Glu
275 280 285

Trp Val Val Ala Arg Gln Glu Ala Asp Gly Cys Trp Gly Gly Ile Gln
290 295 300

Pro Pro Trp Val Tyr Ser Val Met Ala Leu His Leu Met Gly Tyr Pro
305 310 315 320

Leu Asn His Pro Val Ile Ala Thr Ala Phe Arg Gly Met Glu Arg Tyr
325 330 335

Val Ile Arg Arg Asp Thr Pro Gln Gly Pro Ile Arg Gln Ile Glu Ala
340 345 350

Cys Gln Ser Pro Val Trp Asp Thr Ala Leu Ala Val Val Ala Leu Ala
355 360 365

Asp Ala Gly Val Pro Gly Asp His Pro Ala Met Val Lys Ala Gly Arg
370 375 380

Trp Leu Val Asp Glu Glu Val Arg Val Ala Gly Asp Trp Ala Val Arg
385 390 395 400

Arg Pro Glu Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe Asp Asn Asp
405 410 415

Phe Tyr Pro Asp Val Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg
420 425 430

Arg Leu Leu Gly Ala Gly His Val Ala Pro Pro Ala Ser Arg Gln Gly
435 440 445

Arg Ala Glu Ala Pro Pro Val Asn Thr Val Glu Asp Ala Asp Pro Arg
450 455 460

Leu Ala Ala Ala Met Arg Ala Ala Ala Ala Arg Gly Val Asp Trp Ser
465 470 475 480

Val Gly Met Arg Ser Ser Asn Gly Ala Trp Gly Ala Phe Asp Ala Asp
485 490 495

Asn Val Arg Thr Leu Thr Thr Lys Ile Pro Phe Cys Asp Phe Gly Glu
500 505 510

Val Val Asp Pro Pro Ser Ala Asp Val Thr Ala His Ile Val Glu Met
515 520 525

Leu Ala Asp Leu Gly Arg Ser Asp His Pro Ile Thr Gln Arg Ala Val
530 535 540

Gln Trp Leu Leu Asp Asn Gln Glu Pro Gly Gly Ser Trp Phe Gly Arg
545 550 555 560

Trp Gly Val Asn His Leu Tyr Gly Thr Gly Ala Val Val Pro Ala Leu
565 570 575

Ile Gly Ala Gly Val Pro Thr Asp His Pro Ala Ile Thr Ala Ala Val
580 585 590

Arg Trp Leu Leu Glu His Gln Ser Pro Glu Gly Gly Trp Gly Glu Asp
595 600 605

Leu Arg Ser Tyr Thr Asp Pro Ala Trp Ile Gly Arg Gly Glu Leu Thr
610 615 620

Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala Val Asp Pro
625 630 635 640

His Ser Leu Ala Val Lys Arg Gly Val Arg Trp Leu Cys Glu Thr Gln
645 650 655

Arg Pro Asp Gly Thr Trp Asp Glu Pro Tyr Phe Thr Gly Thr Gly Phe
660 665 670

Pro Gly Asp Phe Ser Leu Asn Tyr His Leu Tyr Arg Leu Val Phe Pro
675 680 685

Leu Thr Ala Leu Gly Arg Tyr Val Ser Leu Thr Gly Val Ala Thr Pro
690 695 700




<210> 130
<211> 741
<212> PRT
<213> Frankia sp.

<400> 130
Met Ser Leu Thr Ser Asp Pro Ser Pro Ala Ala Pro Lys Ala Ala Lys
1 5 10 15

Ser Ser Lys Arg Val Asn Ile Pro Ala Pro Ala Thr Pro Asp Ala Tyr
20 25 30

Gly Ile Ser Arg Ser Ser Pro Pro Leu Ser Gly Gly Gly Val Ser Gly
35 40 45

Gly Gly Val Ser Gly Gly Gly Ala Ala Thr Ala Asp Gly Thr Pro Pro
50 55 60

Thr Thr Gln Thr Ser Val Asp Pro Asp Leu Ala Ala Ala Met Thr Ala
65 70 75 80

Ala Asn Gln Ala Arg Asp His Leu Leu Gly Leu Gln Ser Glu Glu Gly
85 90 95

Trp Trp Lys Gly Asp Leu Glu Thr Asn Val Thr Ile Asp Ala Glu His
100 105 110

Leu Phe Met Lys Gln Phe Leu Gly Ile Arg Thr Glu Glu Glu Thr Glu
115 120 125

Pro Ile Ala Arg Trp Val Arg Ser Gln Gln Leu Ala Asp Gly Gly Trp
130 135 140

Ala Thr Tyr Tyr Gly Gly Pro Ala Glu Leu Ser Thr Thr Val Glu Ala
145 150 155 160

Tyr Ile Ala Leu Arg Leu Ala Gly Asp Glu Pro Asp Ala Pro His Met
165 170 175

Ala Ala Ala Ala Ala Leu Ile Arg Ser Gln Gly Gly Val Ala Ala Ala
180 185 190

Arg Val Phe Thr Arg Ile Trp Leu Ala Thr Phe Gly Glu Trp Ser Trp
195 200 205

Asp Asp Val Pro Val Leu Pro Pro Glu Leu Ile Phe Leu Pro Ser Trp
210 215 220

Phe Pro Leu Asn Val Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile
225 230 235 240

Val Ala Leu Thr Ile Val Gly Ser Leu Arg Pro Val Arg Asp Leu Gly
245 250 255

Phe Ser Ile Asp Glu Ile Lys Val Ala Ala Pro Val Thr Pro Pro Lys
260 265 270

Pro Ala Pro Leu His Ser Trp Glu Gly Ala Phe Glu Arg Leu Asp Ala
275 280 285

Ile Leu His Arg Tyr Glu Arg Arg Pro Ile Lys Val Leu Arg Thr Leu
290 295 300

Ala Leu Arg Arg Ala Thr Glu Trp Val Val Ala Arg Gln Glu Ala Asp
305 310 315 320

Gly Cys Trp Gly Gly Ile Gln Pro Pro Trp Ile Tyr Ser Val Met Ala
325 330 335

Leu His Leu Met Gly Tyr Pro Leu Asn His Pro Val Ile Ala Thr Ala
340 345 350

Phe Arg Gly Met Glu Arg Tyr Ile Ile Arg Arg Glu Thr Pro Glu Gly
355 360 365

Pro Thr Ala Gln Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Ala
370 375 380

Leu Ala Val Val Ala Leu Ser Asp Ala Gly Val Pro Ala Asp His Pro
385 390 395 400

Ala Met Val Arg Ala Gly Arg Trp Leu Val Asp Glu Glu Val Arg Val
405 410 415

Ala Gly Asp Trp Ala Val Arg Arg Pro Ala Leu Ala Pro Gly Gly Trp
420 425 430

Ala Phe Glu Phe Asp Asn Asp Phe Tyr Pro Asp Thr Asp Asp Thr Ala
435 440 445

Glu Val Val Leu Ala Leu Arg Arg Leu Leu Gly Gly Ser His Val Thr
450 455 460

Pro Gly Gly Thr Val Thr Pro Ser Gly Ser Val Thr Pro Gly Gly Thr
465 470 475 480

Ala Glu Leu Ser Pro Ala Ala Arg Asp Arg Ala Ser Arg Gly Leu Ala
485 490 495

Ala Val Asp Pro Gln Leu Ala Gly Ala Met Arg Ala Ala Ala Ala Arg
500 505 510

Gly Val Asp Trp Ser Val Gly Met Arg Ser Ser Asp Gly Ala Trp Gly
515 520 525

Ala Phe Asp Ala Asp Asn Val Arg Thr Leu Thr Ala Lys Ile Pro Phe
530 535 540

Cys Asp Phe Gly Glu Val Val Asp Pro Pro Ser Ala Asp Val Thr Ala
545 550 555 560

His Ile Val Glu Met Leu Ala Asp Leu Gly Arg Ser Asp His Pro Ile
565 570 575

Thr Arg Arg Ala Val Gln Trp Leu Leu Asp Asn Gln Glu Pro Gly Gly
580 585 590

Ser Trp Phe Gly Arg Trp Gly Ile Asn His Val Tyr Gly Thr Gly Ala
595 600 605

Val Val Pro Ala Leu Ile Ala Ala Gly Val Pro Ala Asp His Pro Ala
610 615 620

Ile Thr Ala Ala Val Arg Trp Leu Leu Glu His Gln Ser Pro Asp Gly
625 630 635 640

Gly Trp Gly Glu Asp Pro Arg Ser Tyr Asp Asp Pro Ala Trp Ile Gly
645 650 655

Arg Gly Glu Leu Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu
660 665 670

Leu Ala Val Asp Pro His Ser Lys Ala Val Lys Arg Gly Val Arg Trp
675 680 685

Leu Cys Glu Thr Gln Arg Pro Asp Gly Thr Trp Asp Glu Pro Gln Phe
690 695 700

Thr Gly Thr Gly Phe Pro Gly Asp Phe Tyr Leu Asn Tyr His Leu Tyr
705 710 715 720

Arg Leu Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val Thr Leu Thr
725 730 735

Gly Val Ala Thr Pro
740


<210> 131
<211> 728
<212> PRT
<213> Frankia sp.

<400> 131
Met Ser Leu Thr Ser Asp Gln Ser Ser Ala Ala Pro Thr Ala Ala Ala
1 5 10 15

Gln Ser Pro Lys Ile Pro Asn Pro Ser Val Ala Arg Pro Ser Ala Asp
20 25 30

Ala Gly Ser Phe Glu Thr Ala Gly Ala Val Arg Thr Asp Ser Val Ser
35 40 45

Ile Asp Ser Val Ser Thr Gly Thr Pro Val Asp Pro Val Val Gly Ala
50 55 60

Met Arg Arg Gly Arg Asp His Leu Leu Ser Leu Gln Ala Glu Glu Gly
65 70 75 80

Trp Trp Lys Gly Glu Leu Glu Thr Asn Val Thr Met Asp Ala Glu Asp
85 90 95

Leu Met Leu Arg Gln Phe Leu Gly Ile Leu Thr Pro Ser Thr Ala Thr
100 105 110

Glu Thr Gly Arg Trp Ile Arg Ser Gln Gln Leu Ser Asp Gly Gly Trp
115 120 125

Ala Thr Phe Tyr Gly Gly Pro Ser Asp Leu Ser Thr Thr Ile Glu Ala
130 135 140

Tyr Val Ala Leu Arg Leu Ala Gly Asp Asp Pro Asp Ala Pro His Met
145 150 155 160

Arg Ser Ala Ala Glu Trp Val Arg Ser Ala Gly Gly Ile Ala Ala Ser
165 170 175

Arg Val Phe Thr Arg Ile Trp Leu Ala Leu Phe Gly Glu Trp Ser Trp
180 185 190

Asp Asp Val Pro Val Leu Pro Ala Glu Met Thr Phe Leu Pro Pro Trp
195 200 205

Phe Pro Leu Asn Ile Tyr Asp Phe Ala Cys Trp Ala Arg Gln Thr Val
210 215 220

Val Ala Leu Thr Ile Val Gly Ser Leu Arg Pro Val Arg Ser Phe Gly
225 230 235 240

Phe Thr Leu Asp Glu Leu Arg Val Gln Ala Pro Lys Ala Thr Lys Ala
245 250 255

Pro Leu Arg Ser Trp Ala Gly Ala Phe Glu Arg Leu Asp Ser Val Leu
260 265 270

His Arg Tyr Glu Lys Arg Pro Phe Gln Pro Leu Arg Arg Leu Ala Leu
275 280 285

Arg Arg Ala Ala Glu Trp Val Ile Ala Arg Gln Glu Ala Asp Gly Cys
290 295 300

Trp Gly Gly Ile Gln Pro Pro Met Val Tyr Ser Ile Met Ala Leu His
305 310 315 320

Leu Met Gly Tyr Pro Leu Asn His Pro Val Ile Ser Met Ala Phe Arg
325 330 335

Ala Leu Asp Arg Phe Thr Ile Arg Glu Glu Thr Pro Glu Gly Thr Val
340 345 350

Arg Arg Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Ala Leu Ala
355 360 365

Val Val Ala Leu Ala Asp Ala Gly Leu Gly Gly Asp His Pro Ala Met
370 375 380

Val Arg Ala Gly Arg Trp Leu Ala Asp Glu Glu Val Arg Val Ala Gly
385 390 395 400

Asp Trp Ala Val Arg Arg Pro Thr Leu Ala Pro Gly Gly Trp Ala Phe
405 410 415

Glu Phe Asp Asn Asp Phe Tyr Pro Asp Val Asp Asp Thr Ala Glu Val
420 425 430

Val Ile Ala Ile Arg Arg Leu Leu Gly Asp Gly His Gly Pro Val Asp
435 440 445

His Ser Asp Gly Ser Gly Pro Gly Ser Ala Ala Ala Thr Ala Ala Ser
450 455 460

Ala Ala Ala Glu Ala Ala Val Ala Ala Ala Gly Thr Ile Ala Ala Ala
465 470 475 480

Asp Pro Glu Leu Ala Ala Arg Leu Arg Ala Ala Ala Glu Arg Gly Val
485 490 495

Asp Trp Ser Val Gly Met Arg Ser Ser Asn Gly Ala Trp Ala Ala Phe
500 505 510

Asp Ala Asp Asn Val Arg Thr Leu Val Arg Lys Ile Pro Phe Cys Asp
515 520 525

Phe Gly Glu Val Val Asp Pro Pro Ser Ala Asp Val Thr Ala His Met
530 535 540

Val Glu Met Leu Ala Leu Leu Gly Arg Ser Asp His Pro Ile Thr Gln
545 550 555 560

Arg Gly Val Arg Trp Leu Leu Asp Asn Gln Glu Ala Gly Gly Ser Trp
565 570 575

Phe Gly Arg Trp Gly Val Asn His Val Tyr Gly Thr Gly Ala Val Val
580 585 590

Pro Ala Leu Ile Ser Ala Gly Val Asp Ala Glu His Pro Ala Ile Val
595 600 605

Ser Ser Met His Trp Leu Val Glu His Gln Thr Pro Glu Gly Gly Trp
610 615 620

Gly Glu Asp Leu Arg Ser Tyr Arg Asp Asp Glu Trp Ile Gly Arg Gly
625 630 635 640

Glu Pro Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala
645 650 655

Ala Glu Pro Ala Ser Gly Thr Ala Glu Trp Glu Ala Val Glu Arg Gly
660 665 670

Val Arg Trp Leu Cys Asp Thr Gln Arg Pro Asp Gly Thr Trp Asp Glu
675 680 685

Pro Gln Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr
690 695 700

His Leu Tyr Arg Leu Val Phe Pro Val Thr Ala Leu Gly Arg Tyr Val
705 710 715 720

Thr Leu Thr Gly Arg Ser Thr Ser
725


<210> 132
<211> 689
<212> PRT
<213> Frankia sp.

<400> 132
Met Phe Gln Gly Ser Asp Arg Pro Pro Val Thr Leu Val Met Asn Asp
1 5 10 15

Met Arg Gly Pro Asp Met Asn Val Ser Asp Thr Val Ser Val Thr Arg
20 25 30

Glu Ser Ile Pro Thr Gln Thr Ser Ala Gly Asp Ala Thr Ala Arg Asp
35 40 45

Leu Thr Ala Ala Val Gly Ser Glu Leu Thr Arg Ala Leu Arg Leu Ala
50 55 60

Thr Asp His Leu Leu Ala Leu Gln Asp Gly Thr Gly Trp Trp Lys Phe
65 70 75 80

Asp Leu Glu Thr Asn Thr Ser Met Asp Ala Glu Asp Leu Leu Leu Arg
85 90 95

Glu Tyr Leu Gly Ile Arg Thr Thr Glu Val Thr Ala Ala Ser Ala Arg
100 105 110

Phe Ile Arg Ser Arg Gln Ser Asp Asp Gly Ser Trp Pro Gln Tyr Phe
115 120 125

Gly Gly Pro Gly Glu Leu Ser Thr Thr Val Glu Ser Tyr Ile Ala Leu
130 135 140

Arg Leu Ala Gly Asp Asp Ala Ser Ala Pro His Met Leu Ser Ala Ala
145 150 155 160

Thr Trp Val Arg Asp His Gly Gly Val Pro Ala Thr Arg Val Phe Thr
165 170 175

Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Arg Trp Glu Asp Leu Pro
180 185 190

Ala Leu Pro Pro Glu Ile Met Leu Leu Pro Arg Arg Ala Pro Leu Asn
195 200 205

Ile Tyr Ser Phe Gly Ser Trp Ala Arg Gln Thr Leu Val Ser Leu Thr
210 215 220

Val Val Ser Ala Leu Arg Pro Val Arg Pro Ala Pro Phe Asp Leu Asp
225 230 235 240

Glu Leu Tyr Pro Asp Gly Pro Ala Ser Ala Trp Ser Gly Ala Gly Pro
245 250 255

Ser Asn Val Leu Glu Arg Ile Ser Thr Arg Phe Thr Ala Lys Glu Ile
260 265 270

Phe Leu Gly Ile Asp Arg Leu Leu His Val Tyr His Arg Arg Pro Val
275 280 285

Arg Ser Met Arg Asn His Ala Leu Arg Ala Ala Glu Arg Trp Ile Ile
290 295 300

Ala Arg Gln Glu Ala Asp Gly Cys Phe Gly Gly Ile Gln Pro Pro Ala
305 310 315 320

Val Tyr Ser Ile Ile Ala Leu Arg Leu Leu Gly Tyr Glu Leu Asp His
325 330 335

Pro Val Leu Lys Ala Ala Leu Arg Ala Leu Asp Asp Tyr Ser Val Thr
340 345 350

Leu Pro Asp Gly Ser Arg Met Val Glu Ala Ser Gln Ser Pro Val Trp
355 360 365

Asp Thr Ala Leu Ala Val Asn Ala Leu Ala Asp Ala Gly Ala Thr Ala
370 375 380

Ala Ile Ala Pro Asp His Pro Ala Leu Val Arg Ala Ala Gly Trp Leu
385 390 395 400

Leu Gly Gln Glu Val Arg His Arg Arg Gly Asp Trp Ala Val Asn His
405 410 415

Pro Asp Val Pro Ala Ser Gly Trp Ala Phe Glu Phe Glu Asn Asp Thr
420 425 430

Tyr Pro Asp Thr Asp Asp Thr Ala Glu Val Leu Leu Ala Leu Arg Arg
435 440 445

Val Arg His Pro Ala Arg Asp Glu Leu Asp Ala Ala Glu Arg Arg Ala
450 455 460

Val Ala Trp Leu Phe Gly Leu Gln Ser Ser Asp Gly Gly Trp Gly Ala
465 470 475 480

Tyr Asp Ala Asp Asn Thr Ser Thr Ile Pro Tyr Gln Ile Pro Phe Ala
485 490 495

Asp Phe Gly Ala Leu Thr Asp Pro Pro Ser Ala Asp Val Thr Ala His
500 505 510

Val Val Glu Leu Leu Ala Glu Ala Gly Leu Gly Gly Asp Asp Arg Thr
515 520 525

Arg Arg Gly Val Asp Trp Leu Leu Asp His Gln Glu Ala Asp Gly Ser
530 535 540

Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser Val
545 550 555 560

Met Pro Ala Leu Arg Ala Ala Gly Leu Glu Pro Ser His Pro Ala Met
565 570 575

Arg Ala Gly Ala Asp Trp Leu Leu Thr His Gln Asn Ala Asp Gly Gly
580 585 590

Trp Gly Glu Asp Leu Arg Ser Tyr Thr Asp Pro Glu Trp Ser Gly Arg
595 600 605

Gly Glu Ser Thr Ala Ser Gln Thr Ala Trp Ala Met Leu Ala Leu Leu
610 615 620

Thr Val Gly Asp Gln Pro Glu Val Ser Gly Ala Leu Ala Arg Gly Ala
625 630 635 640

Arg Trp Leu Ala Asp His Gln Arg Pro Asp Gly Ser Trp Asp Glu Asp
645 650 655

Gln Phe Thr Gly Thr Gly Phe Pro Gly Asp Phe Tyr Ile Asn Tyr His
660 665 670

Gly Tyr Arg Leu Leu Trp Pro Ile Met Ala Leu Gly Arg Tyr Leu Arg
675 680 685

Gly


<210> 133
<211> 773
<212> PRT
<213> Frankia sp. EuI1c

<400> 133
Met Thr Thr Thr Asp Glu Thr Ala Leu Ala Ala Gly Thr Pro Lys Ala
1 5 10 15

Ala Phe Ala Pro Ala Pro Arg Gly Ala Ala Asp Asp Leu Val Ala Arg
20 25 30

Thr Val Ala Val Glu Ala Pro Pro Ser Pro Ala Pro Ala Ser Asp Asp
35 40 45

Thr Leu Ala Arg Ala Val Ala His Leu Lys Ser Leu Gln Asp Glu Ala
50 55 60

Gly Trp Trp Lys Gly Asp Leu Glu Thr Asn Thr Thr Met Asp Ser Glu
65 70 75 80

Asp Leu Met Leu Arg His Trp Leu Gly Ile Trp Asn Pro Glu Gln Ala
85 90 95

Glu Arg Thr Ala Arg Phe Ile Arg Ser Lys Gln Tyr Ala Asp Gly Ser
100 105 110

Trp Pro Ile Tyr His Ala Gly Pro Gly Asp Leu Asn Ala Thr Val Glu
115 120 125

Ser Tyr Val Ala Leu Arg Met Val Gly Asp Ser Pro Gln Asp Pro His
130 135 140

Met Arg Ala Ala Ala Ala Trp Ala Arg Ala Arg Gly Gly Val Pro Ala
145 150 155 160

Thr Arg Ile Phe Thr Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Arg
165 170 175

Trp Glu Asp Leu Pro Val Leu Pro Pro Glu Leu Ile Phe Val Pro Ala
180 185 190

Lys Met Pro Leu Ser Ile Tyr Lys Phe Ala Ser Trp Gly Arg Gln Thr
195 200 205

Ile Val Ala Ile Met Val Leu Met Ala His Arg Pro Ala Gly Thr Pro
210 215 220

Pro Phe Pro Ile Ala Glu Leu Phe Pro Pro Pro Ala Thr Lys Lys Lys
225 230 235 240

Ala Ala Ala Gln Arg Lys Ala Gln Lys Lys Ala Gly His Ala Gly Gly
245 250 255

Pro Thr Ala Trp Arg Asp Ser Ser Ile Asp Asp Met Phe Thr Glu Pro
260 265 270

Ala Pro Gly Thr Asp Thr Leu Arg Gln Pro Ala Ala Leu Ala Ile Gly
275 280 285

Pro Ala Arg Pro Ala Pro Ala Lys Gly Arg Arg Gly Lys Gly Gln Pro
290 295 300

Ala Ala Pro Asp Val Met Gly Arg Ala Lys Asp Gly Gly Gly Pro Gly
305 310 315 320

Leu Pro Leu Pro Ala Arg Leu Val Ser Arg Val Gly Phe Arg Thr Arg
325 330 335

Arg Ala Leu Arg Gln Ala Ala Leu Asp His Val Asn Trp Asn Leu Leu
340 345 350

Phe Gly Gly Ile Asp Arg Phe Leu His Val Tyr His Arg His Pro Ile
355 360 365

Arg Pro Val Arg Ser Leu Ala Leu Gly Leu Ala Glu Arg Trp Ile Val
370 375 380

Val Arg Gln Glu Ala Asp Gly Cys Phe Gly Gly Ile Gln Pro Pro Thr
385 390 395 400

Val Tyr Ser Ile Met Ala Leu Arg Val Leu Gly Tyr Pro Met Asp His
405 410 415

Pro Val Met Thr Ala Ala Leu Arg Ser Leu Asp Glu Tyr Ser Val Thr
420 425 430

Leu Pro Asp Gly Ala Arg Met Gln Glu Ala Cys Gln Ser Pro Val Trp
435 440 445

Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp Ala Gly Val Pro Arg
450 455 460

Asp Asp Pro Ser Leu Val Arg Ala Ala Asp Trp Met Leu Ala Glu Glu
465 470 475 480

Val Arg Glu Arg Arg Gly Asp Trp Ser Val Pro Ile Pro Asp Val Pro
485 490 495

Thr Gly Gly Trp Ser Phe Glu Phe Asp Asn Asp Thr Tyr Pro Asp Val
500 505 510

Asp Asp Ser Ala Glu Val Met Leu Ala Leu Met Arg Val Ala His Pro
515 520 525

Arg Pro Glu Lys Val Val Ala Ala Thr Tyr Arg Gly Leu Gln Trp Val
530 535 540

Phe Gly Met Gln Cys Ala Asp Gly Gly Trp Gly Ala Phe Asp Val Asp
545 550 555 560

Asn Ala Gly Glu Leu Val Tyr Lys Ile Pro Phe Ala Asp Phe Gly Met
565 570 575

Leu Thr Asp Pro Pro Ser Ala Asp Val Thr Ala His Val Val Glu Leu
580 585 590

Leu Gly Glu Leu Gly Leu Gly Asp Asp Pro Arg Thr Lys Arg Gly Val
595 600 605

Glu Trp Leu Leu His Ser Gln Glu Ala Asp Gly Ser Trp Tyr Gly Arg
610 615 620

Trp Gly Val Asn His Leu Tyr Gly Thr Gly Gly Val Val Pro Ala Leu
625 630 635 640

Arg Ala Ala Gly Leu Pro Ala Ser His Pro Ala Ile Gln Arg Ala Ala
645 650 655

Asp Trp Leu Val Ala Lys Gln Asn Pro Asp Gly Gly Trp Gly Glu Ser
660 665 670

Cys Tyr Ser Tyr Asp Glu Met Ser Thr Ala Gly Val Gly Val Ser Thr
675 680 685

Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Ile Ala Ala Gly Arg
690 695 700

Val Gly Asp Gly Val Thr Gly Glu Ala Ala Ala Arg Gly Val Ala Trp
705 710 715 720

Leu Ala Glu Thr Gln Thr Ala Glu Gly Thr Trp Asp Glu Asp Tyr Phe
725 730 735

Thr Gly Thr Gly Phe Ala Gly Tyr Phe Tyr Ile Asn Tyr His Leu Tyr
740 745 750

Arg Leu Val Trp Pro Val Met Ala Leu Gly Arg Tyr Gln Ala Ala Leu
755 760 765

Ala Gly Lys Gly His
770


<210> 134
<211> 764
<212> PRT
<213> Frankia sp. EuI1c

<400> 134
Met Ser Leu Thr Ser Asp Pro Ser Pro Ala Thr Pro Ala Thr Gln Pro
1 5 10 15

Thr Ser Ala Arg Pro Gly Ser Leu Ser Asp Arg Arg Ser Arg Ser Gly
20 25 30

Gly Ser Ala Val Ala Gly Pro Val Leu Val Thr Thr Arg Pro Val Ala
35 40 45

Pro Val Ala Lys Ser Gly Ala Val Thr Pro Thr Ala Thr Ser Gly Ala
50 55 60

Val Thr Ser Thr Ala Thr Ser Gly Pro Ala Leu Leu Pro Asp Leu Ala
65 70 75 80

Thr Asp Leu Ala Asp Pro Thr Gly Pro Leu Ala Gly Ala Ala Ser Ala
85 90 95

Thr Val Arg Ala Ala Gly Gly Ala Gly Thr Arg Thr Gln Gln Thr Gly
100 105 110

Gln Leu Gly Ser Thr Glu Leu Ala Gly Pro Gln Ala Asp Gln Val Ala
115 120 125

Asp Arg Ala Ala Ala Val Leu Gly Arg Ala Arg Asp His Leu Leu Gly
130 135 140

Leu Gln Ser Glu Ala Gly Trp Trp Lys Gly Glu Leu Glu Thr Asn Val
145 150 155 160

Thr Met Asp Ala Glu Asp Leu Met Leu Arg Gln Phe Leu Gly Ile Leu
165 170 175

Pro Pro Glu Leu Ala Ala Glu Thr Gly Arg Trp Ile Arg Ser Lys Gln
180 185 190

Gln Asp Asp Gly Gly Trp Pro Thr Phe His Gly Gly Pro Ser Asp Leu
195 200 205

Ser Thr Thr Phe Glu Ala Tyr Val Gly Leu Arg Leu Ala Gly Asp Leu
210 215 220

Pro Asp Ala Pro His Met Leu Ala Ala Ala Ser Phe Val Arg Ala His
225 230 235 240

Gly Gly Leu Ala Ala Thr Arg Val Phe Thr Arg Ile Trp Met Ala Leu
245 250 255

Phe Gly Glu Trp Pro Trp Asp Glu Val Pro Val Leu Pro Pro Glu Leu
260 265 270

Val Leu Leu Pro Ser Trp Val Pro Leu Asn Val Tyr Asp Phe Gly Cys
275 280 285

Trp Ala Arg Gln Thr Val Val Ala Leu Thr Ile Val Gly His Phe Arg
290 295 300

Pro Val Arg Ser Leu Gly Phe Ser Ile Asp Glu Leu Arg Val Ala Ala
305 310 315 320

Val Arg Pro Asp Arg Ala Pro Leu Val Ser Trp Thr Gly Val Phe Gln
325 330 335

Arg Leu Asp Ala Gly Leu Arg Arg Tyr Gln Arg His Pro Val Lys Thr
340 345 350

Leu Arg Glu Leu Ala Leu Arg Arg Ala Thr Glu Trp Val Leu Ala Arg
355 360 365

Gln Glu Ala Asp Gly Gly Trp Gly Gly Ile Gln Pro Pro Trp Val Tyr
370 375 380

Ser Ile Met Ala Leu His Leu Met Gly Tyr Ser Met Asp His Pro Val
385 390 395 400

Leu Val Ala Ala Leu Asp Gly Leu Glu Thr Phe Thr Val Arg Glu Gln
405 410 415

Val Arg Glu Gly Asp Glu Val Val Thr Val Arg Arg Leu Glu Ala Cys
420 425 430

Gln Ser Pro Val Trp Asp Thr Ala Leu Ala Val Val Ala Leu Ala Asp
435 440 445

Ala Gly Leu Asp Ala Arg His Pro Ala Met Arg Lys Ala Gly Glu Trp
450 455 460

Leu Val Arg Glu Glu Val Thr Val Pro Gly Asp Trp Arg Val Arg Arg
465 470 475 480

Pro Asn Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Ala Asn Asp Ile
485 490 495

Tyr Pro Asp Val Asp Asp Thr Ala Glu Val Val Leu Ala Val Arg Arg
500 505 510

Leu Leu Gly Ser Gly Trp Asp Asp Val Asp Pro Thr Phe Ala Lys Gln
515 520 525

Ala Arg Ala Ser Val Glu Arg Ala Val Asn Trp Ser Val Gly Met Arg
530 535 540

Ser Ala Asn Gly Ala Trp Gly Ala Phe Asp Ala Asp Asn Val Arg Glu
545 550 555 560

Leu Ala Thr Lys Ile Pro Phe Cys Asp Phe Gly Glu Val Ile Asp Pro
565 570 575

Pro Ser Ala Asp Val Thr Ala His Met Val Glu Met Leu Ala Asp Leu
580 585 590

Gly Arg Ala Asp His Pro Val Thr Gln Arg Ala Val Arg Trp Leu Leu
595 600 605

Asp Asp Gln Glu Pro Gly Gly Ser Trp Phe Gly Arg Trp Gly Val Asn
610 615 620

His Val Tyr Gly Thr Gly Ala Val Val Pro Ala Leu Ile Ser Ala Gly
625 630 635 640

Val Ala Ala Asp His Pro Ala Ile Arg Ser Ala Val Arg Trp Leu Val
645 650 655

Ala His Gln His Pro Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr
660 665 670

Gln Asp Asp Ala Trp Val Gly Arg Gly Glu Pro Thr Ala Ser Gln Thr
675 680 685

Ala Trp Ala Leu Leu Ala Leu Leu Ala Ala Asp Pro Met Asn Glu Ala
690 695 700

Val Gly Arg Gly Val Arg Trp Leu Cys Asp Thr Gln Leu Pro Asn Gly
705 710 715 720

Thr Trp Asp Glu Pro Tyr Tyr Thr Gly Thr Gly Phe Pro Trp Asp Phe
725 730 735

Ser Ile Asn Tyr His Leu Tyr Arg Leu Val Phe Pro Leu Thr Ala Leu
740 745 750

Gly Arg Tyr Val Thr Leu Thr Gly Arg Ser Ala Ala
755 760


<210> 135
<211> 612
<212> PRT
<213> Gemmata obscuriglobus

<400> 135
Met Ile Pro Ala Glu Arg Leu Arg Thr Ala Tyr Arg Thr Ala Arg Ala
1 5 10 15

Ala Leu Leu Ala Glu Arg Val Pro Glu Gly His Trp Val Gly Glu Leu
20 25 30

Ser Thr Ser Ala Leu Ser Thr Ala Thr Ala Val Met Ala Leu His Leu
35 40 45

Val Asn Pro Phe Thr His Arg Glu Leu Ile Asp Ala Gly Arg Lys Trp
50 55 60

Leu Ala Glu His Gln Asn Ala Asp Gly Gly Trp Gly Asp Thr Val Lys
65 70 75 80

Ser Phe Ser Asn Ile Ser Thr Thr Met Leu Cys Arg Ala Ala Phe Lys
85 90 95

Leu Ala Gly Glu Lys Glu Tyr Pro Glu Thr Val Gln Arg Val Glu Glu
100 105 110

Tyr Leu Ser Arg Asn Ala Gly Ala Leu Pro Thr Ala Arg Ala Ala Ala
115 120 125

Ile Arg Ala Arg Tyr Gly Lys Asp His Thr Phe Ser Val Pro Ile Leu
130 135 140

Met Thr Cys Ala Val Ala Lys Leu Val Pro Trp Asp Glu Val Pro Arg
145 150 155 160

Leu Pro Phe Glu Leu Ala Cys Leu Pro Gln Ser Trp Tyr Arg Phe Ala
165 170 175

Lys Leu Pro Val Val Ser Tyr Ala Leu Pro Ala Leu Ile Ala Ile Gly
180 185 190

Gln Cys Ile His His His Arg Arg Ser Gln Asn Pro Ile Arg Asn Thr
195 200 205

Val Arg Arg Leu Ala Arg Gly Leu Ser Leu Lys Val Leu Arg Arg Ile
210 215 220

Gln Pro Thr Ser Gly Gly Tyr Leu Glu Ala Thr Pro Leu Thr Ser Phe
225 230 235 240

Val Val Met Ala Leu Ser Ser Ile Arg Arg Arg Arg Ala Ala Ala Glu
245 250 255

Gln Gln Val Ile Asp Glu Gly Val Arg Phe Leu Val Ala Ser Val Arg
260 265 270

Pro Asp Gly Ser Trp Pro Ile Asp Thr Asn Leu Ala Thr Trp Val Thr
275 280 285

Thr Leu Ser Val Asn Ala Leu Ala Thr Ala Gly Asp Leu Glu Ala Leu
290 295 300

Asp Thr Lys Glu Gln Ile Leu Ala Trp Leu Leu Lys Gln Gln Tyr Lys
305 310 315 320

Glu Arg His Pro Tyr Thr Gly Ala Asp Pro Gly Gly Trp Ala Trp Thr
325 330 335

Asp Leu Pro Gly Gly Val Pro Asp Cys Asp Asp Thr Pro Gly Ala Leu
340 345 350

Ile Ala Leu Ala His Leu Asp Pro Lys Ser Asp Pro Gln Ala Val Leu
355 360 365

Ser Gly Leu Arg Trp Val Leu Arg Leu Gln Asn Gly Asp Gly Gly Ala
370 375 380

Pro Thr Phe Cys Arg Gly Trp Gly Thr Leu Pro Phe Asp Arg Ser Gly
385 390 395 400

Ala Asp Leu Thr Ala His Ser Val Arg Ser Leu Ala Ser Trp Tyr Arg
405 410 415

Val Trp Gly Ala Gly Pro Pro Pro Ile Glu His Leu Arg His Arg Leu
420 425 430

Lys Asp Leu Glu Phe Pro Leu Ser Gly Leu Phe Trp Asp Val Ala Arg
435 440 445

Arg Asn Pro Arg Phe Val Arg Tyr Leu Lys Lys Gln Gln Arg Ser Asp
450 455 460

Gly Ser Trp Leu Pro Leu Trp Phe Gly Asn Gln His Ala Pro Asp Asp
465 470 475 480

Ile Asn Pro Val Tyr Gly Thr Ala Arg Val Leu Ala Ala Tyr Arg Asp
485 490 495

Leu Glu Leu Lys Asp Ala Pro Glu Cys Arg Arg Gly Ile Glu Phe Leu
500 505 510

Leu Ser Val Gln Asn Ala Asp Gly Gly Trp Gly Gly Ala Lys Gly Cys
515 520 525

Pro Ser Ser Val Glu Glu Thr Ala Leu Ala Val Glu Val Leu Leu Asp
530 535 540

Leu Ala Asp Gly Asp Ala Val Gln Lys Gly Val Ala Trp Leu Ala Glu
545 550 555 560

Ala Val Glu Ser Asp Arg Phe Arg Asp Ala Ser Pro Ile Gly Phe Tyr
565 570 575

Phe Ala Lys Leu Trp Tyr Phe Glu Lys Leu Tyr Pro Ile Ile Phe Thr
580 585 590

Val Ala Ala Leu Gly Arg Ala Val Lys Ile Thr Ser Pro Ala Pro Ala
595 600 605

Ala Glu Ser Ala
610


<210> 136
<211> 618
<212> PRT
<213> Geobacillus sp.

<400> 136
Met Val Ala Asp Glu Arg Ser Ala Leu Ile Asp Ala Leu Lys Arg Ser
1 5 10 15

Gln Ser Val Asp Gly Ser Trp Arg Phe Pro Phe Glu Thr Gly Ile Ser
20 25 30

Thr Asp Ala Tyr Met Ile Ile Leu Leu Arg Thr Leu Gly Ile His Asp
35 40 45

Glu Pro Leu Ile Gln Ala Leu Val Glu Arg Ile Glu Ser Arg Gln Asp
50 55 60

Ala Asn Gly Ala Trp Lys Leu Phe Ala Asp Glu Gly Asp Gly Asn Val
65 70 75 80

Thr Ala Thr Val Glu Ala Tyr Tyr Ala Leu Leu Tyr Ser Gly Tyr Arg
85 90 95

Lys Lys Thr Asp Ser His Met Gln Lys Ala Lys Ala Arg Ile Leu Glu
100 105 110

Val Gly Gly Leu Glu Arg Val His Leu Phe Thr Lys Val Met Leu Ala
115 120 125

Leu Thr Gly Gln His Ser Trp Pro Arg Arg Phe Pro Leu Pro Leu Val
130 135 140

Phe Phe Leu Leu Pro Pro Ser Phe Pro Leu Asn Met Tyr Asp Leu Ser
145 150 155 160

Val Tyr Gly Arg Ala Asn Met Val Pro Leu Leu Val Val Ala Glu Arg
165 170 175

Arg Tyr Ser Arg Lys Thr Asp Asn Ser Pro Asp Leu Ser Asp Leu Ala
180 185 190

Ala Ser Arg Asn Asp Trp Arg Leu Pro Asp Thr Glu Ala Leu Trp Ser
195 200 205

Tyr Val Lys Arg Ser Leu Thr Gly Leu Pro Ala Trp Leu His Arg Ala
210 215 220

Ala Glu Gln Arg Ala Val Arg Tyr Met Leu Glu His Ile Glu Pro Asp
225 230 235 240

Gly Thr Leu Tyr Ser Tyr Phe Ser Ser Thr Phe Leu Leu Ile Phe Ala
245 250 255

Leu Leu Ala Leu Gly Tyr Pro Lys Asp Asp Pro His Ile Ala Arg Ala
260 265 270

Val Arg Gly Leu Arg Ser Leu Arg Thr Glu Ile Asp Gly His Thr His
275 280 285

Met Gln Tyr Thr Thr Ala Ser Val Trp Asn Thr Ala Leu Ala Ser Tyr
290 295 300

Ala Leu Gln Glu Ala Gly Val Pro Pro Thr Asp Arg Thr Ile Glu Lys
305 310 315 320

Ala Asn Arg Tyr Leu Leu Ser Arg Gln His Ile Arg Tyr Gly Asp Trp
325 330 335

Ala Val His Asn Pro Tyr Gly Val Pro Gly Gly Trp Gly Phe Ser Asp
340 345 350

Val Asn Thr Met Asn Pro Asp Val Asp Asp Thr Thr Ala Ala Leu Arg
355 360 365

Ala Ile Arg Arg Ala Ala Ala Lys Glu Thr Ala Phe Arg His Ala Trp
370 375 380

Asp Arg Ala Asn Arg Trp Leu Phe Ser Met Gln Asn Asp Asp Gly Gly
385 390 395 400

Phe Ala Ala Phe Glu Lys Asn Val Gly Lys Arg Phe Trp Arg Tyr Leu
405 410 415

Pro Ile Glu Gly Ala Glu Phe Leu Leu Met Asp Pro Ser Thr Ala Asp
420 425 430

Leu Thr Gly Arg Thr Leu Glu Tyr Phe Gly Thr Phe Ala Gly Leu Thr
435 440 445

Lys Asp His Ser Ala Ile Ala Arg Ala Ile Asp Trp Leu Leu Asp His
450 455 460

Gln Glu Ala Asp Gly Ser Trp Tyr Gly Arg Trp Gly Ile Cys Tyr Val
465 470 475 480

Tyr Gly Thr Trp Ala Ala Val Thr Gly Leu Ser Ala Val Gly Val Pro
485 490 495

Ile Asp His Pro Ala Met Gln Lys Ala Val Arg Trp Leu Leu Ser Ile
500 505 510

Gln Asn Asp Asp Gly Gly Trp Gly Glu Ser Cys Lys Ser Asp Gly Ala
515 520 525

Lys Thr Tyr Val Pro Leu Gly Ala Ser Thr Pro Val His Thr Ala Trp
530 535 540

Ala Leu Asp Ala Leu Ile Ala Ala Ala Glu Arg Pro Thr Pro Glu Met
545 550 555 560

Lys Ala Gly Val Arg Ala Leu Val Arg Met Leu His His Pro Asp Trp
565 570 575

Thr Ala Ser Tyr Pro Val Gly Gln Gly Met Ala Gly Ala Phe Tyr Ile
580 585 590

His Tyr His Gly Tyr Arg Tyr Ile Phe Pro Leu Leu Ala Leu Ala His
595 600 605

Tyr Glu Gln Lys Phe Gly Pro Phe Val Asp
610 615


<210> 137
<211> 617
<212> PRT
<213> Geobacillus sp.

<400> 137
Met Ala Gly Glu Arg Ser Ala Leu Ile Thr Ala Leu Lys Arg Ser Gln
1 5 10 15

Ala Ala Asp Gly Ser Trp Arg Phe Pro Phe Glu Thr Gly Ile Ser Thr
20 25 30

Asp Ala Tyr Met Ile Ile Leu Leu Arg Thr Leu Asp Ile Asn Asp Glu
35 40 45

Pro Leu Ile Gln Ala Leu Val Glu Arg Ile Glu Ser Arg Gln Glu Ala
50 55 60

Asn Gly Ala Trp Lys Leu Phe Ala Asp Glu Gly Asp Gly Asn Val Thr
65 70 75 80

Ala Thr Val Glu Ala Tyr Tyr Ala Leu Leu Tyr Ser Gly Tyr Arg Gln
85 90 95

Pro Thr Asp Arg His Met Gln Lys Ala Lys Arg Arg Ile Leu Asp Met
100 105 110

Gly Gly Leu Asp Arg Val His Leu Phe Thr Lys Val Met Leu Ala Leu
115 120 125

Thr Gly Gln Tyr Pro Trp Pro Gly Arg Phe Pro Leu Pro Leu Glu Phe
130 135 140

Phe Leu Leu Pro Pro Ser Phe Pro Leu Asn Met Tyr Asp Leu Ser Val
145 150 155 160

Tyr Gly Arg Ala Asn Met Ile Pro Leu Leu Ile Ala Ala Asp Ser Arg
165 170 175

Tyr Ser Arg Lys Thr Asp Lys Ser Pro Asp Leu Ser Asp Leu Phe Ala
180 185 190

Ser Arg Gly Asp Trp Gly Met Pro Glu Ser Arg Ser Leu Leu Thr Tyr
195 200 205

Val Lys Arg Ser Leu Ile Gly Leu Pro Ala Gln Leu His Gln Ala Ala
210 215 220

Lys Gln Arg Ala Val Arg Tyr Leu Phe Glu His Ile Glu Pro Asp Gly
225 230 235 240

Thr Leu Tyr Ser Tyr Phe Ser Ser Thr Phe Leu Phe Ile Phe Ala Leu
245 250 255

Leu Ala Leu Gly Tyr Arg Asn Asp Asp Pro Arg Ile Arg Gln Ala Val
260 265 270

Arg Gly Leu Arg Ser Leu Arg Thr Thr Ile Asp Gly His Val His Leu
275 280 285

Gln Tyr Thr Thr Ala Ser Val Trp Asn Thr Ala Leu Ala Ser Tyr Thr
290 295 300

Leu Gln Glu Ala Gly Val Pro Met Thr Asp Arg Ala Ile Glu Lys Ala
305 310 315 320

Asn Arg Tyr Leu Leu Ser Arg Gln Asn Val Arg Tyr Gly Asp Trp Ala
325 330 335

Val His Asn Pro Tyr Ser Thr Pro Gly Gly Trp Gly Phe Ser Asp Val
340 345 350

Asn Thr Met Asn Pro Asp Val Asp Asp Thr Thr Ala Ala Leu Arg Ala
355 360 365

Ile Arg Gln Ala Ala Ala Lys Glu Thr Ala Phe Arg His Ala Trp Asp
370 375 380

Arg Ala Asn Gln Trp Leu Phe Ser Met Gln Asn Asp Asp Gly Gly Phe
385 390 395 400

Ala Ala Phe Glu Lys Asn Val Ser Ser Arg Phe Trp Arg Tyr Leu Pro
405 410 415

Ile Glu Gly Ala Glu Phe Leu Leu Met Asp Pro Ser Thr Ala Asp Leu
420 425 430

Thr Gly Arg Thr Leu Glu Tyr Phe Gly Thr Phe Ala Gly Leu Thr Lys
435 440 445

Asp Gln Arg Ala Val Ser Arg Ala Val Asp Trp Leu Leu Ser His Gln
450 455 460

Glu Arg Asn Gly Ser Trp Tyr Gly Arg Trp Gly Ile Cys Tyr Ile Tyr
465 470 475 480

Gly Thr Trp Ala Ala Ile Thr Gly Leu Thr Ala Val Gly Val Pro Ala
485 490 495

His His Pro Ala Leu Gln Lys Ala Val Arg Trp Leu Leu Ser Ile Gln
500 505 510

Asn Asp Asp Gly Gly Trp Gly Glu Ser Cys Lys Ser Asp Gly Ala Lys
515 520 525

Thr Tyr Val Pro Leu Gly Asp Ser Thr Pro Val His Thr Ala Trp Ala
530 535 540

Leu Asp Ala Leu Val Ala Ala Ala Glu Arg Pro Thr Leu Glu Met Lys
545 550 555 560

Ala Gly Phe Arg Ala Leu Phe Arg Leu Leu His His Pro Asp Trp Thr
565 570 575

Ala Ser Tyr Pro Val Gly Gln Gly Met Ala Gly Ala Phe Tyr Ile His
580 585 590

Tyr His Ser Tyr Arg Tyr Ile Phe Pro Leu Leu Ala Leu Ala His Tyr
595 600 605

Glu Gln Lys Phe Gly Pro Leu Asp Asp
610 615


<210> 138
<211> 618
<212> PRT
<213> Geobacillus sp. Y412MC52

<400> 138
Met Val Ala Asp Glu Arg Ser Ala Leu Ile Asp Ala Leu Lys Arg Ser
1 5 10 15

Gln Ser Val Asp Gly Ser Trp Arg Phe Pro Phe Glu Thr Gly Ile Ser
20 25 30

Thr Asp Ala Tyr Met Ile Ile Leu Leu Arg Thr Leu Gly Ile His Asp
35 40 45

Glu Pro Leu Ile Gln Ala Leu Val Glu Arg Ile Glu Ser Arg Gln Asp
50 55 60

Ala Asn Gly Ala Trp Lys Leu Phe Ala Asp Glu Gly Asp Gly Asn Val
65 70 75 80

Thr Ala Thr Val Glu Ala Tyr Tyr Ala Leu Leu Tyr Ser Gly Tyr Arg
85 90 95

Lys Lys Thr Asp Ser His Met Gln Lys Ala Lys Ala Arg Ile Leu Glu
100 105 110

Val Gly Gly Leu Glu Arg Val His Leu Phe Thr Lys Val Met Leu Ala
115 120 125

Leu Thr Gly Gln His Ser Trp Pro Arg Arg Phe Pro Leu Pro Leu Val
130 135 140

Phe Phe Leu Leu Pro Pro Ser Phe Pro Leu Asn Met Tyr Asp Leu Ser
145 150 155 160

Val Tyr Gly Arg Ala Asn Met Val Pro Leu Leu Val Val Ala Glu Arg
165 170 175

Arg Tyr Ser Arg Lys Thr Asp Asn Ser Pro Asp Leu Ser Asp Leu Ala
180 185 190

Ala Ser Arg Asn Asp Trp Arg Leu Pro Asp Thr Glu Ala Leu Trp Ser
195 200 205

Tyr Val Lys Arg Ser Leu Thr Gly Leu Pro Ala Trp Leu His Arg Ala
210 215 220

Ala Glu Gln Arg Ala Val Arg Tyr Met Leu Glu His Ile Glu Pro Asp
225 230 235 240

Gly Thr Leu Tyr Ser Tyr Phe Ser Ser Thr Phe Leu Leu Ile Phe Ala
245 250 255

Leu Leu Ala Leu Gly Tyr Pro Lys Asp Asp Pro His Ile Ala Arg Ala
260 265 270

Val Arg Gly Leu Arg Ser Leu Arg Thr Glu Ile Asp Gly His Thr His
275 280 285

Met Gln Tyr Thr Thr Ala Ser Val Trp Asn Thr Ala Leu Ala Ser Tyr
290 295 300

Ala Leu Gln Glu Ala Gly Val Pro Pro Thr Asp Arg Thr Ile Glu Lys
305 310 315 320

Ala Asn Arg Tyr Leu Leu Ser Arg Gln His Ile Arg Tyr Gly Asp Trp
325 330 335

Ala Val His Asn Pro Tyr Gly Val Pro Gly Gly Trp Gly Phe Ser Asp
340 345 350

Val Asn Thr Met Asn Pro Asp Val Asp Asp Thr Thr Ala Ala Leu Arg
355 360 365

Ala Ile Arg Arg Ala Ala Ala Lys Glu Thr Ala Phe Arg His Ala Trp
370 375 380

Asp Arg Ala Asn Arg Trp Leu Phe Ser Met Gln Asn Asp Asp Gly Gly
385 390 395 400

Phe Ala Ala Phe Glu Lys Asn Val Gly Lys Arg Phe Trp Arg Tyr Leu
405 410 415

Pro Ile Glu Gly Ala Glu Phe Leu Leu Met Asp Pro Ser Thr Ala Asp
420 425 430

Leu Thr Gly Arg Thr Leu Glu Tyr Phe Gly Thr Phe Ala Gly Leu Thr
435 440 445

Lys Asp His Ser Ala Ile Ala Arg Ala Ile Asp Trp Leu Leu Asp His
450 455 460

Gln Glu Ala Asp Gly Ser Trp Tyr Gly Arg Trp Gly Ile Cys Tyr Val
465 470 475 480

Tyr Gly Thr Trp Ala Ala Val Thr Gly Leu Ser Ala Val Gly Val Pro
485 490 495

Ile Asp His Pro Ala Met Gln Lys Ala Val Arg Trp Leu Leu Ser Ile
500 505 510

Gln Asn Asp Asp Gly Gly Trp Gly Glu Ser Cys Lys Ser Asp Gly Ala
515 520 525

Lys Thr Tyr Val Pro Leu Gly Ala Ser Thr Pro Val His Thr Ala Trp
530 535 540

Ala Leu Asp Ala Leu Ile Ala Ala Ala Glu Arg Pro Thr Pro Glu Met
545 550 555 560

Lys Ala Gly Val Arg Ala Leu Val Arg Met Leu His His Pro Asp Trp
565 570 575

Thr Ala Ser Tyr Pro Val Gly Gln Gly Met Ala Gly Ala Phe Tyr Ile
580 585 590

His Tyr His Gly Tyr Arg Tyr Ile Phe Pro Leu Leu Ala Leu Ala His
595 600 605

Tyr Glu Gln Lys Phe Gly Pro Phe Val Asp
610 615


<210> 139
<211> 618
<212> PRT
<213> Geobacillus sp. Y412MC61

<400> 139
Met Val Ala Asp Glu Arg Ser Ala Leu Ile Asp Ala Leu Lys Arg Ser
1 5 10 15

Gln Ser Val Asp Gly Ser Trp Arg Phe Pro Phe Glu Thr Gly Ile Ser
20 25 30

Thr Asp Ala Tyr Met Ile Ile Leu Leu Arg Thr Leu Gly Ile His Asp
35 40 45

Glu Pro Leu Ile Gln Ala Leu Val Glu Arg Ile Glu Ser Arg Gln Asp
50 55 60

Ala Asn Gly Ala Trp Lys Leu Phe Ala Asp Glu Gly Asp Gly Asn Val
65 70 75 80

Thr Ala Thr Val Glu Ala Tyr Tyr Ala Leu Leu Tyr Ser Gly Tyr Arg
85 90 95

Lys Lys Thr Asp Ser His Met Gln Lys Ala Lys Ala Arg Ile Leu Glu
100 105 110

Val Gly Gly Leu Glu Arg Val His Leu Phe Thr Lys Val Met Leu Ala
115 120 125

Leu Thr Gly Gln His Ser Trp Pro Arg Arg Phe Pro Leu Pro Leu Val
130 135 140

Phe Phe Leu Leu Pro Pro Ser Phe Pro Leu Asn Met Tyr Asp Leu Ser
145 150 155 160

Val Tyr Gly Arg Ala Asn Met Val Pro Leu Leu Val Val Ala Glu Arg
165 170 175

Arg Tyr Ser Arg Lys Thr Asp Asn Ser Pro Asp Leu Ser Asp Leu Ala
180 185 190

Ala Ser Arg Asn Asp Trp Arg Leu Pro Asp Thr Glu Ala Leu Trp Ser
195 200 205

Tyr Val Lys Arg Ser Leu Thr Gly Leu Pro Ala Trp Leu His Arg Ala
210 215 220

Ala Glu Gln Arg Ala Val Arg Tyr Met Leu Glu His Ile Glu Pro Asp
225 230 235 240

Gly Thr Leu Tyr Ser Tyr Phe Ser Ser Thr Phe Leu Leu Ile Phe Ala
245 250 255

Leu Leu Ala Leu Gly Tyr Pro Lys Asp Asp Pro His Ile Ala Arg Ala
260 265 270

Val Arg Gly Leu Arg Ser Leu Arg Thr Glu Ile Asp Gly His Thr His
275 280 285

Met Gln Tyr Thr Thr Ala Ser Val Trp Asn Thr Ala Leu Ala Ser Tyr
290 295 300

Ala Leu Gln Glu Ala Gly Val Pro Pro Thr Asp Arg Thr Ile Glu Lys
305 310 315 320

Ala Asn Arg Tyr Leu Leu Ser Arg Gln His Ile Arg Tyr Gly Asp Trp
325 330 335

Ala Val His Asn Pro Tyr Gly Val Pro Gly Gly Trp Gly Phe Ser Asp
340 345 350

Val Asn Thr Met Asn Pro Asp Val Asp Asp Thr Thr Ala Ala Leu Arg
355 360 365

Ala Ile Arg Arg Ala Ala Ala Lys Glu Thr Ala Phe Arg His Ala Trp
370 375 380

Asp Arg Ala Asn Arg Trp Leu Phe Ser Met Gln Asn Asp Asp Gly Gly
385 390 395 400

Phe Ala Ala Phe Glu Lys Asn Val Gly Lys Arg Phe Trp Arg Tyr Leu
405 410 415

Pro Ile Glu Gly Ala Glu Phe Leu Leu Met Asp Pro Ser Thr Ala Asp
420 425 430

Leu Thr Gly Arg Thr Leu Glu Tyr Phe Gly Thr Phe Ala Gly Leu Thr
435 440 445

Lys Asp His Ser Ala Ile Ala Arg Ala Ile Asp Trp Leu Leu Asp His
450 455 460

Gln Glu Ala Asp Gly Ser Trp Tyr Gly Arg Trp Gly Ile Cys Tyr Val
465 470 475 480

Tyr Gly Thr Trp Ala Ala Val Thr Gly Leu Ser Ala Val Gly Val Pro
485 490 495

Ile Asp His Pro Ala Met Gln Lys Ala Val Arg Trp Leu Leu Ser Ile
500 505 510

Gln Asn Asp Asp Gly Gly Trp Gly Glu Ser Cys Lys Ser Asp Gly Ala
515 520 525

Lys Thr Tyr Val Pro Leu Gly Ala Ser Thr Pro Val His Thr Ala Trp
530 535 540

Ala Leu Asp Ala Leu Ile Ala Ala Ala Glu Arg Pro Thr Pro Glu Met
545 550 555 560

Lys Ala Gly Val Arg Ala Leu Val Arg Met Leu His His Pro Asp Trp
565 570 575

Thr Ala Ser Tyr Pro Val Gly Gln Gly Met Ala Gly Ala Phe Tyr Ile
580 585 590

His Tyr His Gly Tyr Arg Tyr Ile Phe Pro Leu Leu Ala Leu Ala His
595 600 605

Tyr Glu Gln Lys Phe Gly Pro Phe Val Asp
610 615


<210> 140
<211> 617
<212> PRT
<213> Geobacillus thermodenitrificans

<400> 140
Met Ala Gly Glu Arg Ser Ala Leu Ile Thr Ala Leu Lys Arg Ser Gln
1 5 10 15

Ala Ala Asp Gly Ser Trp Arg Phe Pro Phe Glu Thr Gly Ile Ser Thr
20 25 30

Asp Ala Tyr Met Ile Ile Leu Leu Arg Thr Leu Asp Ile Asn Asp Glu
35 40 45

Pro Leu Ile Gln Ala Leu Val Glu Arg Ile Glu Ser Arg Gln Glu Ala
50 55 60

Asn Gly Ala Trp Lys Leu Phe Ala Asp Glu Gly Asp Gly Asn Val Thr
65 70 75 80

Ala Thr Val Glu Ala Tyr Tyr Ala Leu Leu Tyr Ser Gly Tyr Arg Gln
85 90 95

Pro Thr Asp Arg His Met Gln Lys Ala Lys Arg Arg Ile Leu Asp Met
100 105 110

Gly Gly Leu Asp Arg Val His Leu Phe Thr Lys Val Met Leu Ala Leu
115 120 125

Thr Gly Gln Tyr Pro Trp Pro Gly Arg Phe Pro Leu Pro Leu Glu Phe
130 135 140

Phe Leu Leu Pro Pro Ser Phe Pro Leu Asn Met Tyr Asp Leu Ser Val
145 150 155 160

Tyr Gly Arg Ala Asn Met Ile Pro Leu Leu Ile Ala Ala Asp Ser Arg
165 170 175

Tyr Ser Arg Lys Thr Asp Lys Ser Pro Asp Leu Ser Asp Leu Phe Ala
180 185 190

Ser Arg Gly Asp Trp Gly Met Pro Glu Ser Arg Ser Leu Leu Thr Tyr
195 200 205

Val Lys Arg Ser Leu Ile Gly Leu Pro Ala Gln Leu His Gln Ala Ala
210 215 220

Lys Gln Arg Ala Val Arg Tyr Leu Phe Glu His Ile Glu Pro Asp Gly
225 230 235 240

Thr Leu Tyr Ser Tyr Phe Ser Ser Thr Phe Leu Phe Ile Phe Ala Leu
245 250 255

Leu Ala Leu Gly Tyr Arg Asn Asp Asp Pro Arg Ile Arg Gln Ala Val
260 265 270

Arg Gly Leu Arg Ser Leu Arg Thr Thr Ile Asp Gly His Val His Leu
275 280 285

Gln Tyr Thr Thr Ala Ser Val Trp Asn Thr Ala Leu Ala Ser Tyr Thr
290 295 300

Leu Gln Glu Ala Gly Val Pro Met Thr Asp Arg Ala Ile Glu Lys Ala
305 310 315 320

Asn Arg Tyr Leu Leu Ser Arg Gln Asn Val Arg Tyr Gly Asp Trp Ala
325 330 335

Val His Asn Pro Tyr Ser Thr Pro Gly Gly Trp Gly Phe Ser Asp Val
340 345 350

Asn Thr Met Asn Pro Asp Val Asp Asp Thr Thr Ala Ala Leu Arg Ala
355 360 365

Ile Arg Gln Ala Ala Ala Lys Glu Thr Ala Phe Arg His Ala Trp Asp
370 375 380

Arg Ala Asn Gln Trp Leu Phe Ser Met Gln Asn Asp Asp Gly Gly Phe
385 390 395 400

Ala Ala Phe Glu Lys Asn Val Ser Ser Arg Phe Trp Arg Tyr Leu Pro
405 410 415

Ile Glu Gly Ala Glu Phe Leu Leu Met Asp Pro Ser Thr Ala Asp Leu
420 425 430

Thr Gly Arg Thr Leu Glu Tyr Phe Gly Thr Phe Ala Gly Leu Thr Lys
435 440 445

Asp Gln Arg Ala Val Ser Arg Ala Val Asp Trp Leu Leu Ser His Gln
450 455 460

Glu Arg Asn Gly Ser Trp Tyr Gly Arg Trp Gly Ile Cys Tyr Ile Tyr
465 470 475 480

Gly Thr Trp Ala Ala Ile Thr Gly Leu Thr Ala Val Gly Val Pro Ala
485 490 495

His His Pro Ala Leu Gln Lys Ala Val Arg Trp Leu Leu Ser Ile Gln
500 505 510

Asn Asp Asp Gly Gly Trp Gly Glu Ser Cys Lys Ser Asp Gly Ala Lys
515 520 525

Thr Tyr Val Pro Leu Gly Asp Ser Thr Pro Val His Thr Ala Trp Ala
530 535 540

Leu Asp Ala Leu Val Ala Ala Ala Glu Arg Pro Thr Leu Glu Met Lys
545 550 555 560

Ala Gly Phe Arg Ala Leu Phe Arg Leu Leu His His Pro Asp Trp Thr
565 570 575

Ala Ser Tyr Pro Val Gly Gln Gly Met Ala Gly Ala Phe Tyr Ile His
580 585 590

Tyr His Ser Tyr Arg Tyr Ile Phe Pro Leu Leu Ala Leu Ala His Tyr
595 600 605

Glu Gln Lys Phe Gly Pro Leu Asp Asp
610 615


<210> 141
<211> 680
<212> PRT
<213> Geobacter bemidjiensis

<400> 141
Met Thr Ser Pro Phe Lys His Pro Ile Ser Asn Ala Leu Thr Ser Phe
1 5 10 15

Asn Gly Asn Val Ala Glu Pro Glu Gln Ser Val Glu Gln Gln Ser Gly
20 25 30

Ala Lys Val His His Leu Pro Ala Ser Ile Trp Lys Arg Lys Met Gly
35 40 45

Arg Ala Lys Ser Pro Leu Asp Val Ala Ile Glu Gly Ser Arg Asp Phe
50 55 60

Phe Phe Gln Glu Gln Leu Pro Lys Gly Tyr Trp Trp Ala Glu Leu Glu
65 70 75 80

Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Met Leu Phe His Phe Leu
85 90 95

Gly Leu Val Asp Pro Glu Arg Gln Arg Lys Met Ser Thr Tyr Leu Leu
100 105 110

Ser Lys Gln Thr Glu Glu Gly Phe Trp Thr Ile Tyr Tyr Gly Gly Pro
115 120 125

Gly Asp Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys Leu Ser
130 135 140

Gly Tyr Pro Glu Asp His Pro Ala Leu Ala Lys Ala Arg Ala Phe Ile
145 150 155 160

Leu Glu Gln Gly Gly Val Val Lys Ser Arg Val Phe Thr Lys Ile Phe
165 170 175

Leu Ala Leu Phe Gly Glu Phe Asp Trp Gln Gly Ile Pro Ser Met Pro
180 185 190

Val Glu Leu Asn Leu Leu Pro Asp Trp Ala Tyr Ile Asn Ile Tyr Glu
195 200 205

Phe Ser Ser Trp Ala Arg Ala Thr Ile Val Pro Leu Ser Val Val Met
210 215 220

His Ser Arg Pro Val Arg Arg Val Pro Pro Ser Ala Arg Val Gln Glu
225 230 235 240

Leu Phe Val Arg Gln Pro Thr Ala Ala Asp Tyr Ser Phe Ala Lys Asn
245 250 255

Asp Gly Leu Phe Thr Trp Glu Lys Phe Phe Leu Gly Leu Asp Arg Val
260 265 270

Leu Lys Val Tyr Glu Lys Ser Pro Leu Arg Pro Phe Lys Lys Thr Ala
275 280 285

Leu Ala Lys Ala Glu Glu Trp Val Leu Glu His Gln Glu Pro Thr Gly
290 295 300

Asp Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ala Ile Leu Ala Leu
305 310 315 320

Asn Val Leu Gly Tyr Arg Asn Asp His Pro Ala Val Glu Gln Gly Leu
325 330 335

Arg Ala Leu Ala Asn Phe Cys Ile Glu Thr Glu Asp Gln Leu Val Leu
340 345 350

Gln Ser Cys Val Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Lys Ala
355 360 365

Leu Leu Asp Ala Gly Val Pro Pro Asp His Pro Ser Leu Val Lys Gly
370 375 380

Ala Gln Trp Leu Leu Asp Lys Glu Val Thr Arg Ala Gly Asp Trp Arg
385 390 395 400

Val Lys Ser Pro Asn Leu Glu Ala Gly Gly Trp Ala Phe Glu Phe Leu
405 410 415

Asn Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Phe Val Met Ile Ala
420 425 430

Leu Lys Gly Ile Gln Val Lys Asp His Lys Ala Met Asp Ala Ala Ile
435 440 445

Lys Arg Gly Ile Asn Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly
450 455 460

Trp Gly Ala Phe Asp Lys Asp Asn Thr Lys His Val Leu Asn Lys Ile
465 470 475 480

Pro Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu
485 490 495

Thr Gly Arg Met Leu Glu Leu Met Gly Thr Phe Asp Tyr Pro Val Thr
500 505 510

Phe Pro Ala Ala Gln Arg Ala Ile Glu Phe Leu Lys Lys Asn Gln Glu
515 520 525

Pro Glu Gly Pro Trp Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly
530 535 540

Thr Trp Ser Val Leu Cys Gly Leu Ala Ala Ile Gly Glu Asp Met Asp
545 550 555 560

Gln Pro Tyr Ile Arg Lys Ala Val Asn Trp Ile Lys Ser Arg Gln Asn
565 570 575

Ile Asp Gly Gly Trp Gly Glu Thr Cys Gln Ser Tyr His Asp Arg Thr
580 585 590

Leu Ala Gly Val Gly Glu Ser Thr Pro Ser Gln Thr Gly Trp Ala Leu
595 600 605

Leu Ser Leu Leu Ala Ala Gly Glu Met His Ser Ala Thr Val Val Arg
610 615 620

Gly Val Gln Tyr Leu Ile Ser Thr Gln Asn Ser Asp Gly Thr Trp Asp
625 630 635 640

Glu Gln Gln Tyr Thr Gly Thr Gly Phe Pro Lys Tyr Phe Met Ile Lys
645 650 655

Tyr His Ile Tyr Arg Asn Cys Phe Pro Leu Met Ala Leu Gly Thr Tyr
660 665 670

Arg Thr Leu Thr Arg Thr Gln Pro
675 680


<210> 142
<211> 684
<212> PRT
<213> Geobacter lovleyi

<400> 142
Met Lys Ser Arg Lys Tyr Pro Ile Ser His Ala Leu Thr Ser Phe Asn
1 5 10 15

His Thr Thr Val Ala Pro Val Glu Ala Pro Ala Pro Ile Ser Val Lys
20 25 30

Ser Pro Ala Lys Val His Arg Leu Pro Ser Ser Ile Trp Lys Lys Met
35 40 45

Glu Gly Ser Ala Gly Asn Pro Leu Asp Lys Ala Val Glu Leu Thr Arg
50 55 60

Asp Phe Phe Phe Arg Glu Gln Leu Pro Asp Gly Tyr Trp Trp Ala Glu
65 70 75 80

Leu Glu Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Met Leu Phe His
85 90 95

Phe Leu Gly Met Val Asp Lys Asp Lys Glu Arg Lys Met Ala Asn Tyr
100 105 110

Leu Leu Arg Gln Gln Thr Glu Glu Gly Tyr Trp Thr Val Trp His Asn
115 120 125

Gly Pro Gly Asp Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys
130 135 140

Leu Ala Gly Tyr His Ala Asp His Ile Ala Leu Arg Lys Ala Arg Asp
145 150 155 160

Phe Ile Leu Ala Asn Gly Gly Ile Leu Lys Ser Arg Val Phe Thr Lys
165 170 175

Thr Phe Leu Ala Met Phe Gly Glu Phe Ser Trp Leu Gly Val Pro Ser
180 185 190

Met Pro Ile Glu Leu Met Leu Leu Pro Asp Trp Ala Tyr Leu Asn Val
195 200 205

Tyr Glu Phe Ser Ser Trp Ala Arg Ala Thr Ile Ile Pro Met Ser Val
210 215 220

Leu Met Ala Asn Arg Pro Val Tyr Lys Leu Pro Pro His Ala Arg Val
225 230 235 240

Gln Glu Leu Tyr Val Arg Pro Pro Arg Pro Thr Asp Tyr Thr Phe Thr
245 250 255

Lys Glu Asp Gly Ile Phe Ser Leu Lys Asn Phe Phe Ile Gly Val Asp
260 265 270

His Leu Leu Lys Ile Tyr Glu Ser Ser Pro Ile Arg Pro Phe Lys Lys
275 280 285

Arg Ala Thr Glu Lys Val Glu Gln Trp Ile Leu Glu His Gln Glu Lys
290 295 300

Thr Gly Asp Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ala Ile Leu
305 310 315 320

Ala Leu His Cys Leu Gly Tyr Ala Asn Asp His Pro Ala Val Ala Lys
325 330 335

Gly Leu Glu Ala Leu Ala Asn Phe Thr Ile Glu Asp Ser Asp Ser Leu
340 345 350

Val Leu Gln Ser Cys Ile Ser Pro Val Trp Asp Thr Ala Leu Val Leu
355 360 365

Gln Ala Met Gln Glu Ala Ser Val Pro Leu Asp His Pro Ser Leu Ile
370 375 380

Lys Ala Ser Gln Trp Leu Leu Asp Arg Glu Val Arg Ile Lys Gly Asp
385 390 395 400

Trp Lys Ile Lys Ser Pro Asp Leu Glu Pro Gly Gly Trp Ala Phe Glu
405 410 415

Phe Gln Asn Asp Trp Tyr Pro Asp Val Asp Asp Ser Thr Ala Val Met
420 425 430

Ile Ala Ile Lys Asp Ile Lys Val Lys Asn Thr Lys Ala Arg Gln Asp
435 440 445

Ala Ile Arg Arg Gly Ile Asp Trp Cys Leu Gly Met Gln Ser Glu Asn
450 455 460

Gly Gly Trp Ala Ala Phe Asp Lys Asp Asn Thr Lys His Met Leu Asn
465 470 475 480

Lys Ile Pro Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala
485 490 495

Asp Leu Thr Gly Arg Met Leu Glu Leu Met Gly Asn Phe Gly Tyr Thr
500 505 510

Lys Asp His Pro Gln Ala Val Ser Ala Leu Glu Phe Leu Lys Asn Glu
515 520 525

Gln Glu Pro Glu Gly Pro Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile
530 535 540

Tyr Gly Thr Trp Tyr Val Leu Ile Gly Leu Glu Ala Ile Gly Glu Asp
545 550 555 560

Met Asn Ser Pro Tyr Ile Lys Lys Ser Val Asn Trp Ile Lys Ser Arg
565 570 575

Gln Asn Leu Asp Gly Gly Trp Gly Glu Val Cys Asp Ser Tyr Trp Asp
580 585 590

Arg Thr Leu Met Gly Cys Gly Pro Ser Thr Ala Ser Gln Thr Ser Trp
595 600 605

Ala Leu Met Ala Leu Met Ala Ala Gly Glu Val Gly Cys Gln Ala Val
610 615 620

Glu Arg Gly Ile Gln Tyr Leu Leu Ala Thr Gln Asn Ser Asp Gly Thr
625 630 635 640

Trp Asp Glu Glu Ala Phe Thr Gly Thr Gly Phe Pro Lys Tyr Phe Met
645 650 655

Ile Lys Tyr His Ile Tyr Arg Asn Cys Phe Pro Leu Thr Ala Leu Gly
660 665 670

Arg Tyr Arg Arg Leu Thr Ala Gly Thr His Ala Gln
675 680


<210> 143
<211> 730
<212> PRT
<213> Geobacter metallireducens

<400> 143
Met Ala Lys Gly Ile Leu Asn Lys Phe Ala Val Ile Ala Gly Asn Lys
1 5 10 15

Asn Ala Gly Leu Thr Ala Glu Glu Glu Cys Thr Val Val Ala Pro Ile
20 25 30

Lys Glu Val Ser Gly Lys Ala Val His Cys Arg Gln Ala Val Lys Met
35 40 45

Ala Glu Glu Tyr Leu Leu Ala Leu Gln Asn Pro Glu Gly Tyr Trp Val
50 55 60

Phe Glu Leu Glu Ala Asp Val Thr Ile Pro Ser Glu Tyr Ile Met Leu
65 70 75 80

Gln Arg Phe Leu Gly Arg Glu Ile Ser Pro Glu Leu Arg Met Arg Leu
85 90 95

Glu Asn Tyr Leu Leu Asp Arg Gln Leu Pro Asp Gly Gly Trp Pro Leu
100 105 110

Tyr Ala Val Asp Gly Phe Ala Asn Ile Ser Ala Thr Val Lys Ala Tyr
115 120 125

Leu Ala Leu Lys Val Leu Gly His Ser Pro Gln Ala Pro His Met Ile
130 135 140

Arg Ala Arg Ile Met Val Leu Ser Leu Gly Gly Ala Ala Arg Cys Asn
145 150 155 160

Val Phe Thr Arg Ile Leu Leu Ala Leu Phe Gly Gln Leu Pro Trp His
165 170 175

Thr Pro Pro Ala Met Pro Val Glu Ile Val Leu Leu Pro Gln Arg Phe
180 185 190

Phe Phe His Leu Ser Lys Val Ser Tyr Trp Ser Arg Thr Val Ile Val
195 200 205

Pro Met Leu Leu Leu Tyr Ala Lys Gln Pro Val Cys Arg Leu Arg Pro
210 215 220

Glu Glu Gly Ile Pro Glu Leu Phe Asn Thr Pro Pro Asp Lys Leu Arg
225 230 235 240

Asn Leu Asp Gly Phe Gln Ser Gly Arg Trp Arg Lys Asn Ala Phe Ile
245 250 255

Ile Ile Asp Arg Leu Leu Lys Arg Phe Asn Arg Phe Ile Pro Ser Ala
260 265 270

Ile His Arg Lys Ala Met Ala Glu Ala Glu His Trp Thr Arg Ser Arg
275 280 285

Met Gln Gly Ser Gly Gly Ile Gly Ala Ile Phe Pro Ala Met Ala Tyr
290 295 300

Ala Val Met Ala Leu Arg Val Leu Gly Cys Arg Glu Asp Asp Pro Asp
305 310 315 320

Tyr Val Arg Gly Met Gln Ala Ile Asp Asp Leu Leu Gln His Arg Thr
325 330 335

Pro Gln Glu Ala Asp Ser Pro Arg Thr Gly Gly Pro Cys Ile Asp Ser
340 345 350

Gly Thr Ser Ala Ala Phe Ala Phe Asp Pro Ser Pro His Ala Ala Ala
355 360 365

Asp Gly Arg Gly Asn Ser Ser Ile Cys Gln Pro Cys Asn Ser Pro Ile
370 375 380

Trp Asp Thr Cys Leu Ser Leu Ser Ala Leu Met Glu Ala Gly Met Pro
385 390 395 400

Ala Ser His Pro Ala Ala Lys Gln Ala Val Glu Trp Leu Leu Ser Gln
405 410 415

Gln Ile Phe Ser Pro Gly Asp Trp Ser Leu Lys Ala Pro Asp Leu Glu
420 425 430

Gly Gly Gly Trp Ala Phe Gln Phe Glu Asn Thr Leu Tyr Pro Asp Leu
435 440 445

Asp Asp Thr Ser Lys Val Ile Met Ser Leu Leu Arg Ala Gly Ala Leu
450 455 460

Glu Asn Gly Leu Tyr Arg Asp Arg Val Ala Arg Gly Val Asn Trp Val
465 470 475 480

Leu Gly Met Gln Ser Ser Asp Gly Gly Trp Ala Ala Phe Asp Ile Asp
485 490 495

Asn Asn Tyr His Tyr Leu Asn Asp Ile Pro Phe Ala Asp His Gly Ala
500 505 510

Leu Leu Asp Pro Ser Thr Ser Asp Leu Thr Gly Arg Cys Ile Glu Leu
515 520 525

Leu Ser Met Val Gly Phe Asp Arg Thr Phe Pro Pro Ile Ala Gln Gly
530 535 540

Ile Gly Phe Leu Arg Ser Lys Gln Glu Gly Ser Gly Ala Trp Phe Gly
545 550 555 560

Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Ser Gly
565 570 575

Leu Arg Gln Ala Gly Glu Asp Met Gln Gln Pro Tyr Ile Arg Arg Ala
580 585 590

Val Gly Trp Leu Thr Ser Cys Gln Asn His Asp Gly Gly Trp Gly Glu
595 600 605

Thr Cys Tyr Ser Tyr Asp Asp Pro Ser Leu Ala Gly Gln Gly Glu Ser
610 615 620

Thr Pro Ser Gln Thr Ala Trp Ser Leu Leu Gly Leu Met Ala Ala Gly
625 630 635 640

Asp Val His Ser Leu Ala Val Arg Arg Gly Val Arg Tyr Leu Leu Asp
645 650 655

His Gln Asn Gln Trp Gly Thr Trp Glu Glu Lys His Phe Thr Gly Thr
660 665 670

Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg His Tyr
675 680 685

Phe Pro Leu Trp Ala Leu Gly Val Tyr Ser Arg Leu Ser Ser Gly Gln
690 695 700

Lys Thr Arg Gln Glu Glu Arg Arg His Ser Ser Pro Gly Asp Leu His
705 710 715 720

Leu Pro Trp Leu Glu Arg Ile Gly Arg Arg
725 730


<210> 144
<211> 679
<212> PRT
<213> Geobacter metallireducens

<400> 144
Met Lys Ile Ser Lys His Pro Ile Ser His Ala Leu Thr Ser Phe Asn
1 5 10 15

Glu Thr Ala Lys Glu Thr Lys Glu Glu Pro Gln Lys Lys Arg Gly Gly
20 25 30

Lys Val His His Leu Pro Ala Ser Ile Trp Lys Lys Arg Asp Val Glu
35 40 45

Thr Thr Ser Pro Leu Asp Gln Ala Ile Lys Arg Ser Gln Glu Phe Phe
50 55 60

Leu Arg Glu Gln Leu Pro Ala Gly Tyr Trp Trp Ala Glu Leu Glu Ser
65 70 75 80

Asn Val Thr Ile Thr Ala Glu Tyr Val Ile Leu Phe His Phe Met Gly
85 90 95

Leu Val Asn Arg Asp Lys Asp Arg Lys Met Ala Thr Tyr Leu Leu Ser
100 105 110

Lys Gln Thr Glu Glu Gly Cys Trp Cys Ile Trp His Gly Gly Pro Gly
115 120 125

Asp Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys Leu Ala Gly
130 135 140

Tyr Pro Ala Asp His Pro Ala Met Gln Lys Ala Arg Thr Phe Ile Leu
145 150 155 160

Gly Lys Gly Gly Ile Leu Lys Ala Arg Val Phe Thr Lys Ile Phe Leu
165 170 175

Ala Leu Phe Gly Glu Phe Ser Trp Leu Gly Val Pro Ser Met Pro Ile
180 185 190

Glu Met Met Leu Leu Pro Asn Gly Phe Thr Phe Asn Leu Tyr Glu Phe
195 200 205

Ser Ser Trp Ser Arg Ala Thr Ile Ile Pro Leu Ser Ile Val Met Ala
210 215 220

Glu Arg Pro Val Arg Lys Leu Pro Pro Trp Ala Arg Val Gln Glu Leu
225 230 235 240

Tyr Val Arg Pro Pro Arg Pro Met Asp Tyr Thr Phe Thr Lys Glu Asp
245 250 255

Gly Ile Leu Thr Trp Lys Asn Ile Phe Ile Gly Ile Asp His Ile Leu
260 265 270

Lys Val Tyr Glu Ala Ser Pro Ile Arg Pro Gly Met Lys Lys Ala Met
275 280 285

Ala Ile Ala Glu Gln Trp Val Leu Asp His Gln Glu Pro Thr Gly Asp
290 295 300

Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ser Val Leu Ala Leu His
305 310 315 320

Cys Leu Gly Tyr Ala Asn Asp His Pro Ala Val Ala Lys Gly Leu Gln
325 330 335

Ala Leu Ala Asn Phe Cys Ile Glu Ser Asp Asp Glu Ile Val Leu Gln
340 345 350

Ser Cys Ile Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Met Ala Met
355 360 365

Val Asp Ser Glu Val Pro Thr Asp His Pro Ala Leu Val Lys Ala Ala
370 375 380

Gln Trp Leu Leu Asp Arg Glu Val Arg Lys Val Gly Asp Trp Lys Ile
385 390 395 400

Lys Ala Pro Asn Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Gln Asn
405 410 415

Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Ile Val Met Met Ala Ile
420 425 430

Lys Asp Val Lys Val Lys Asp Ser Lys Ala Lys Ala Glu Ala Ile Gln
435 440 445

Arg Gly Ile Ala Trp Cys Ile Gly Met Gln Ser Lys Asn Gly Gly Trp
450 455 460

Gly Ala Phe Asp Lys Asp Asn Thr Lys His Ile Leu Asn Lys Ile Pro
465 470 475 480

Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr
485 490 495

Gly Arg Met Leu Glu Leu Met Gly Thr Phe Gly Tyr Pro Lys Asp His
500 505 510

Pro Ala Ala Val Arg Ala Leu Gln Phe Val Lys Glu Asn Gln Glu Pro
515 520 525

Asp Gly Pro Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr
530 535 540

Trp Ser Val Leu Cys Gly Leu Lys Ala Tyr Gly Glu Asp Met Gly Gln
545 550 555 560

Pro Tyr Val Arg Lys Ala Val Glu Trp Leu Ala Ala His Gln Asn Pro
565 570 575

Asp Gly Gly Trp Gly Glu Cys Cys Glu Ser Tyr Cys Asp Gln Lys Leu
580 585 590

Ala Gly Thr Gly Pro Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Leu
595 600 605

Ser Met Leu Ala Ala Gly Asp Val Asp His Pro Ala Val Ala Arg Gly
610 615 620

Ile Arg Tyr Leu Ile Glu Thr Gln Gln Pro Asp Gly Thr Trp Asp Glu
625 630 635 640

Asp Gln Phe Thr Gly Thr Gly Phe Pro Lys Tyr Phe Met Ile Lys Tyr
645 650 655

His Ile Tyr Arg Asn Cys Phe Pro Leu Met Ala Met Gly Arg Tyr Arg
660 665 670

Ala Leu Lys Gly His Lys Gly
675


<210> 145
<211> 714
<212> PRT
<213> Geobacter sp.

<400> 145
Met Asn Lys His Lys Gly Thr Phe Ser Val Ile Glu Gly Gly Lys Thr
1 5 10 15

Thr Gln Ala Arg Gly Ser Glu Thr Cys Ala Ile Met Asp Ala Ala Asp
20 25 30

Leu Glu Lys Val Thr Ser Val Ala Ala Ser Gln Leu Ala Gly Gln Gln
35 40 45

Gln Asp Asp Gly His Trp Val Phe Asp Leu Glu Ala Asp Val Thr Ile
50 55 60

Pro Ala Glu Tyr Val Met Leu Gln Arg Phe Ile Gly Arg Glu Ile Asp
65 70 75 80

Pro Glu Ile Ser Glu Arg Leu Ala Ala Tyr Met Gln Glu Arg Gln Leu
85 90 95

Pro Asp Gly Gly Trp Pro Leu Tyr Ala Val Asp Gly Asn Val Asn Ile
100 105 110

Ser Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Leu Leu Gly His Asp
115 120 125

Lys Asn Ala Pro His Met Val Arg Ala Arg Gln Leu Ile Leu Ser Leu
130 135 140

Gly Gly Ala Ala Lys Cys Asn Val Phe Thr Arg Ile Thr Leu Ala Thr
145 150 155 160

Phe Gly Gln Ile Pro Trp His Thr Ala Pro Ala Met Pro Ile Glu Ile
165 170 175

Met Leu Leu Pro Arg Trp Phe Phe Phe His Leu Asn Lys Val Ala Tyr
180 185 190

Trp Ser Arg Thr Val Ile Val Pro Leu Leu Ile Leu Tyr Ala Thr Gln
195 200 205

Pro Ile Cys Arg Leu Gln Tyr Asn Glu Gly Ile Thr Glu Leu Phe Thr
210 215 220

Thr Pro Pro Asp Met Leu Val His Leu Asp Lys Phe Arg His His Ala
225 230 235 240

Trp Arg Lys Asn Val Phe Ile Ala Leu Asp Arg Val Leu Lys Arg Thr
245 250 255

Met His Leu Val Pro Gly Arg Ile Lys Gln His Ala Leu Ala Glu Ala
260 265 270

Glu Arg Trp Thr Arg Ala Arg Met Gln Gly Asp Gly Gly Ile Gly Ala
275 280 285

Ile Tyr Pro Ala Met Ala Asn Ala Val Met Ala Leu Lys Thr Leu Gly
290 295 300

Cys Ser Asp Asp Asp Ala Asp Tyr Leu Arg Gly Leu Glu Ala Val Asp
305 310 315 320

Asn Leu Met Val His Arg Asn Leu Lys Thr Gly Thr Ile Pro Met Asp
325 330 335

Asp Asp Ser Gly Gly Ile Ala Ile Asp Asn Ser Ser Ala Ala Pro Glu
340 345 350

Leu Ser Pro Thr Tyr Leu Thr Asp Thr Ala Gly Asn Thr Glu Phe Ser
355 360 365

Phe Cys Gln Pro Cys Asn Ser Pro Ile Trp Asp Thr Cys Met Ser Leu
370 375 380

Ser Ala Leu Cys Glu Ser Gly Tyr Ala Glu Asn Asn Ser Gly Val Thr
385 390 395 400

Asp Arg Ala Ile Lys Trp Leu Phe Ser Gln Gln Ile Ala Thr Pro Gly
405 410 415

Asp Trp Ser Glu Lys Cys Pro Gly Leu Glu Ser Gly Gly Trp Ala Phe
420 425 430

Gln Tyr Glu Asn Ser Arg Tyr Pro Asp Val Asp Asp Thr Ala Lys Val
435 440 445

Leu Met Ser Leu Phe Arg Ala Gly Ala Leu Glu Lys Pro Glu Tyr Arg
450 455 460

Glu Lys Ile Glu Arg Ala Ile Arg Trp Val Gln Gly Met Gln Ser Thr
465 470 475 480

Asp Gly Gly Trp Gly Ala Phe Asp Val Asp Asn Asp Tyr Phe Tyr Leu
485 490 495

Asn Asp Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Ser Thr
500 505 510

Ala Asp Leu Thr Gly Arg Cys Ile Glu Met Met Gly Met Leu Gly His
515 520 525

Gly Pro Asp Tyr Pro Pro Ile Ala Arg Gly Ile Ala Tyr Leu Lys Lys
530 535 540

Glu Gln Glu Pro Phe Gly Gly Trp Phe Gly Arg Trp Gly Val Asn Tyr
545 550 555 560

Ile Tyr Gly Thr Trp Ser Val Leu Ser Gly Leu His Gln Ala Gly Glu
565 570 575

Asn Met Asp Ala Pro Tyr Val Arg Lys Ala Val Glu Trp Leu Ile Ser
580 585 590

Cys Gln Asn Ser Asp Gly Gly Trp Gly Glu Thr Cys Ala Ser Tyr Asp
595 600 605

Asp Pro Ser Leu Ala Gly Ser Gly Ala Ser Thr Ala Ser Gln Thr Ser
610 615 620

Trp Ala Leu Met Ala Leu Met Ala Ala Gly Glu Trp Arg His Ser Ala
625 630 635 640

Val Arg Asn Gly Val Arg Tyr Leu Thr Glu Ser Tyr Cys Asn Gly Trp
645 650 655

Asn Glu Lys Gln Phe Thr Gly Thr Gly Phe Pro Arg Val Phe Tyr Leu
660 665 670

Arg Tyr His Gly Tyr Ser Leu Phe Phe Pro Val Trp Ala Leu Ala Val
675 680 685

Tyr Ser Arg Tyr Ile Asn Gly Thr Ala Thr Val Gln Glu Lys Val Arg
690 695 700

Glu Lys Gln Phe Arg Gln Cys Leu Met Val
705 710


<210> 146
<211> 680
<212> PRT
<213> Geobacter sp.

<400> 146
Met Thr Ser Pro Phe Lys His Pro Ile Ser Asn Ala Leu Thr Ser Phe
1 5 10 15

Asn Gly Asn Phe Ala Glu Pro Glu Gln Cys Val Glu Gln Gln Thr Gly
20 25 30

Ala Lys Val His His Leu Pro Ala Ser Ile Trp Lys Arg Lys Met Gly
35 40 45

Lys Ala Lys Ser Pro Leu Asp Val Ala Ile Glu Gly Ser Arg Asp Phe
50 55 60

Phe Phe Gln Glu Gln Leu Pro Lys Gly Tyr Trp Trp Ala Glu Leu Glu
65 70 75 80

Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Met Leu Phe His Phe Leu
85 90 95

Gly Leu Val Asp Arg Glu Arg Gln Arg Lys Met Ser Asn Tyr Leu Leu
100 105 110

Ser Lys Gln Thr Glu Glu Gly Phe Trp Pro Ile Tyr Tyr Gly Gly Pro
115 120 125

Gly Asp Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys Leu Ser
130 135 140

Gly Tyr Pro Ala Asp His Pro Ala Leu Ala Lys Ala Arg Ala Phe Ile
145 150 155 160

Leu Glu Gln Gly Gly Val Val Lys Ser Arg Val Phe Thr Lys Ile Phe
165 170 175

Leu Ala Leu Phe Gly Glu Phe Glu Trp Gln Gly Val Pro Ser Met Pro
180 185 190

Val Glu Leu Asn Leu Leu Pro Asp Trp Ala Tyr Ile Asn Ile Tyr Glu
195 200 205

Phe Ser Ser Trp Ala Arg Ala Thr Ile Val Pro Leu Ser Val Val Met
210 215 220

His Ser Arg Pro Val Arg Arg Val Pro Pro Ser Ala Arg Val Gln Glu
225 230 235 240

Leu Phe Val Arg Gln Pro Thr Ala Ala Asp Tyr Ser Phe Ala Lys Asn
245 250 255

Asp Gly Ile Phe Thr Trp Glu Asn Phe Phe Leu Gly Leu Asp Arg Val
260 265 270

Leu Lys Val Tyr Glu Lys Ser Pro Leu Arg Pro Phe Lys Asn Met Ala
275 280 285

Leu Ala Lys Ala Glu Glu Trp Val Leu Glu His Gln Glu Pro Thr Gly
290 295 300

Asp Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ala Val Leu Ala Leu
305 310 315 320

Asn Val Leu Gly Tyr Gln Asn Asp His Pro Ala Val Glu Gln Gly Leu
325 330 335

Arg Ala Leu Ala Asn Phe Cys Ile Glu Thr Glu Asp Gln Leu Val Leu
340 345 350

Gln Ser Cys Val Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Lys Ala
355 360 365

Leu Leu Asp Ala Gly Val Pro Pro Asp His Pro Ser Leu Val Lys Gly
370 375 380

Ala Gln Trp Leu Leu Asp Lys Glu Val Thr Arg Pro Gly Asp Trp Arg
385 390 395 400

Val Lys Ser Pro Ala Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu
405 410 415

Asn Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Phe Val Met Ile Ala
420 425 430

Leu Lys Gly Ile Gln Val Lys Asp Arg Lys Ser Met Asp Ala Ala Ile
435 440 445

Lys Arg Gly Ile Asn Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly
450 455 460

Trp Gly Ala Phe Asp Lys Asp Asn Thr Arg His Val Leu Asn Lys Ile
465 470 475 480

Pro Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu
485 490 495

Thr Gly Arg Met Leu Glu Leu Met Gly Thr Phe Asn Tyr Pro Ile Thr
500 505 510

Leu Pro Ala Ala Gln Arg Ala Ile Glu Phe Leu Lys Lys Asn Gln Glu
515 520 525

Pro Glu Gly Pro Trp Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly
530 535 540

Thr Trp Ser Val Leu Cys Gly Leu Ala Ala Ile Gly Glu Asp Met Asp
545 550 555 560

Gln Pro Tyr Ile Arg Lys Ala Val Asn Trp Ile Lys Ser Arg Gln Asn
565 570 575

Ile Asp Gly Gly Trp Gly Glu Thr Cys Gln Ser Tyr His Asp Arg Thr
580 585 590

Leu Ala Gly Val Gly Glu Ser Thr Pro Ser Gln Thr Gly Trp Ala Leu
595 600 605

Leu Gly Leu Leu Ala Ala Gly Glu Met His Ser Ala Thr Val Val Arg
610 615 620

Gly Val Gln Tyr Leu Ile Ser Thr Gln Asn Ser Asp Gly Thr Trp Asp
625 630 635 640

Glu Gln Gln Tyr Thr Gly Thr Gly Phe Pro Lys Tyr Phe Met Ile Lys
645 650 655

Tyr His Ile Tyr Arg Asn Cys Phe Pro Leu Met Ala Leu Gly Thr Tyr
660 665 670

Arg Thr Leu Thr Arg Thr Gln Pro
675 680


<210> 147
<211> 688
<212> PRT
<213> Geobacter sp.

<400> 147
Met Ser Pro Cys Lys His Pro Ile Ser His Ala Leu Thr Ser Phe Asn
1 5 10 15

Gly Glu Thr Ala Asp Ser Val Pro Val Gln Thr Pro Lys Thr Gly Ala
20 25 30

Lys Ile His His Leu Pro Pro Ser Ile Trp Lys Lys Lys Glu Gly Glu
35 40 45

Leu Lys Ser Pro Leu Asp Ile Ala Ile Glu Asn Ser Arg Asp Phe Phe
50 55 60

Phe Arg Glu Gln Leu Pro Asp Gly Tyr Trp Trp Ala Glu Leu Glu Ser
65 70 75 80

Asn Cys Thr Ile Thr Ala Glu Tyr Val Met Leu Tyr His Phe Met Asp
85 90 95

Leu Val Asp Arg Glu Arg Glu Arg Lys Met Ala Asn Tyr Leu Leu Ser
100 105 110

Lys Gln Thr Glu Glu Gly Phe Trp Thr Ile Tyr Tyr Gly Gly Pro Gly
115 120 125

Asp Leu Ser Thr Thr Val Glu Ala Tyr Phe Ala Leu Lys Leu Ala Gly
130 135 140

Tyr Pro Ala Asp His Pro Ala Met Val Lys Ala Arg Ala Phe Ile Leu
145 150 155 160

Asp Asn Gly Gly Ile Ile Lys Thr Arg Val Phe Thr Lys Ile Phe Leu
165 170 175

Ala Leu Phe Gly Glu Phe Ala Trp Phe Gly Val Pro Ser Met Pro Ile
180 185 190

Glu Leu Ile Leu Leu Pro Asn Trp Ala Tyr Phe Asn Met Tyr Glu Leu
195 200 205

Ser Ser Trp Ser Arg Ala Thr Ile Ile Pro Leu Ser Ile Val Met Thr
210 215 220

Gln Arg Pro Val Arg Lys Leu Pro Pro Ala Ser Arg Val Gln Glu Leu
225 230 235 240

Tyr Val Arg Pro Pro Ser Pro Ile Asp Tyr Thr Phe Thr Lys Glu Asp
245 250 255

Gly Ile Phe Thr Trp Lys Asn Phe Phe Ile Gly Val Asp His Ile Leu
260 265 270

Lys Val Tyr Glu Ser Asn Pro Ile Arg Pro Phe Lys Lys Lys Ala Met
275 280 285

Leu Ala Ala Glu Asn Trp Val Leu Glu His Gln Glu Ala Thr Gly Asp
290 295 300

Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ser Val Leu Ala Leu His
305 310 315 320

Cys Leu Gly Tyr Ala Asn Asn His Pro Ala Val Ala Lys Gly Leu Glu
325 330 335

Ala Leu Glu Asn Phe Cys Ile Glu Ser Glu Asp Ser Leu Val Leu Gln
340 345 350

Ser Cys Ile Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Lys Ala Leu
355 360 365

Val Asp Ser Asp Val Pro Asn Asp His Pro Ala Leu Val Lys Ala Ala
370 375 380

Gln Trp Leu Leu Asp Lys Glu Ile Arg Lys Ala Gly Asp Trp Lys Val
385 390 395 400

Lys Ser Pro Glu Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu Asn
405 410 415

Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Phe Val Met Met Ala Leu
420 425 430

Lys Asp Val Ala Val Lys Asp Arg Lys Ser Met Asp Thr Ala Ile Lys
435 440 445

Arg Gly Ile Ser Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Trp
450 455 460

Gly Ala Phe Asp Lys Asp Asn Thr Lys Tyr Leu Leu Asn Lys Ile Pro
465 470 475 480

Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Val Asp Leu Thr
485 490 495

Gly Arg Met Met Glu Leu Met Gly Thr Phe Gly Tyr Ala Lys Asp Tyr
500 505 510

Pro Pro Ala Val Arg Ala Leu Asp Phe Ile Lys Arg Asn Gln Glu Pro
515 520 525

Asp Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr
530 535 540

Trp Ser Val Leu Cys Gly Leu Ser Ala Met Gly Glu Asp Leu Asn Gln
545 550 555 560

Pro Tyr Ile Arg Lys Ala Ile Asn Trp Leu Lys Ser Arg Gln Asn Ile
565 570 575

Asp Gly Gly Trp Gly Glu Thr Cys Glu Ser Tyr His Asp Ser Ser Leu
580 585 590

Ala Gly Ile Gly Ala Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Leu
595 600 605

Ala Leu Met Ala Val Gly Glu Glu Asn Ala Ser Ala Val Ala Arg Gly
610 615 620

Val Gln Tyr Leu Leu Ala Thr Gln Lys Ser Asp Gly Thr Trp Asp Glu
625 630 635 640

Asp Leu Tyr Thr Gly Thr Gly Phe Pro Lys Phe Phe Met Ile Lys Tyr
645 650 655

His Ile Tyr Arg Asn Cys Phe Pro Leu Thr Ala Leu Gly Thr Tyr Arg
660 665 670

Arg Lys Thr Gly Gly Arg Ala Glu Met Gln Val Ser Glu His Asn Lys
675 680 685




<210> 148
<211> 680
<212> PRT
<213> Geobacter sp. M18

<400> 148
Met Thr Ser Pro Phe Lys His Pro Ile Ser His Ala Leu Thr Ser Phe
1 5 10 15

Asn Gly Ile Val Thr Glu Pro Glu Gln Ser Val Glu Gln Lys Ala Gly
20 25 30

Ala Lys Val His Gln Phe Pro Ala Ser Leu Trp Lys Ser Lys Pro Gly
35 40 45

Lys Ala Lys Ser Pro Leu Asp Ile Ala Ile Glu Gly Cys Arg Asp Phe
50 55 60

Phe Phe Arg Glu Gln Leu Pro Lys Gly Tyr Trp Trp Ala Glu Leu Glu
65 70 75 80

Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Met Leu Phe Asn Phe Leu
85 90 95

Ser Leu Val Asp His Glu Arg Gln Arg Lys Met Ser Asn Tyr Leu Leu
100 105 110

Ser Lys Gln Thr Glu Glu Gly Phe Trp Thr Ile Tyr Tyr Gly Gly Pro
115 120 125

Gly Asp Leu Ser Thr Thr Val Glu Ala Tyr Phe Ala Leu Lys Leu Thr
130 135 140

Gly Tyr Pro Ala Asp His Pro Ala Met Val Lys Ala Arg Ala Phe Ile
145 150 155 160

Leu Glu Lys Gly Gly Val Ile Lys Ser Arg Val Phe Thr Lys Ile Phe
165 170 175

Leu Ala Leu Phe Gly Glu Phe Asp Trp Leu Gly Val Pro Ser Met Pro
180 185 190

Val Glu Leu Asn Leu Leu Pro Asn Trp Ala Tyr Val Asn Val Tyr Glu
195 200 205

Phe Ser Ser Trp Ala Arg Ala Thr Ile Ile Pro Leu Ser Ile Val Met
210 215 220

Leu Lys Arg Pro Val His Lys Leu Pro Pro Ser Gln Arg Val Gln Glu
225 230 235 240

Leu Phe Val Arg Pro Pro Arg Ala Ile Asp Tyr Thr Phe Thr Lys Glu
245 250 255

Asp Gly Ile Phe Thr Trp Lys Asn Phe Phe Ile Gly Leu Asp His Met
260 265 270

Leu Lys Val Tyr Glu Arg Ser Pro Val Arg Pro Phe Lys Lys Arg Ala
275 280 285

Met Gly Lys Ala Glu Glu Trp Val Leu Glu His Gln Glu Glu Thr Gly
290 295 300

Asp Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ala Val Leu Ala Leu
305 310 315 320

Ser Ala Leu Gly Tyr Asp Asn Gly His Pro Ala Val Ala His Gly Leu
325 330 335

Lys Ala Leu Glu Asn Phe Cys Ile Glu Ser Asp Glu Gln Ile Val Leu
340 345 350

Gln Ser Cys Ile Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Lys Ala
355 360 365

Leu Val Asp Ala Gly Val Pro Ser Asp His Pro Ser Leu Val Lys Gly
370 375 380

Ala Gln Trp Leu Leu Glu Arg Glu Val Arg Arg Pro Gly Asp Trp Arg
385 390 395 400

Val Lys Ser Pro Asp Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu
405 410 415

Asn Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Phe Val Met Ile Ala
420 425 430

Leu Lys Gly Val Glu Val Lys Asp Arg Lys Ala Met Asn Ala Ala Val
435 440 445

Lys Arg Gly Ile Asp Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly
450 455 460

Trp Gly Ala Phe Asp Lys Asp Asn Thr Arg His Ile Leu Asn Lys Ile
465 470 475 480

Pro Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu
485 490 495

Thr Gly Arg Met Leu Glu Leu Met Gly Thr Phe Gly Tyr Ala Lys Thr
500 505 510

Tyr Pro Ala Ala Gln Arg Ala Leu Lys Phe Leu Lys Glu Asn Gln Glu
515 520 525

Pro Glu Gly Pro Trp Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly
530 535 540

Thr Trp Ser Val Leu Cys Gly Leu Ala Ala Ile Gly Glu Asp Leu Glu
545 550 555 560

Gln Pro Tyr Ile Lys Lys Ala Val Asn Trp Ile Lys Ser Arg Gln Asn
565 570 575

Met Asp Gly Gly Trp Gly Glu Thr Cys Glu Ser Tyr His Asp Pro Thr
580 585 590

Leu Ala Gly Met Gly Glu Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu
595 600 605

Leu Gly Leu Met Ala Ala Gly Glu Val His Ser Ala Thr Val Val Arg
610 615 620

Gly Val Gln Tyr Leu Ile Ser Thr Gln Ser Gln Asp Gly Thr Trp Asp
625 630 635 640

Glu Thr Gln Tyr Thr Gly Thr Gly Phe Pro Lys Tyr Phe Met Ile Lys
645 650 655

Tyr His Ile Tyr Arg Asn Cys Phe Pro Leu Met Ala Leu Gly Thr Tyr
660 665 670

Arg Thr Leu Thr Gly Gly Thr Ala
675 680


<210> 149
<211> 680
<212> PRT
<213> Geobacter sp. M21

<400> 149
Met Thr Ser Pro Phe Lys His Pro Ile Ser Asn Ala Leu Thr Ser Phe
1 5 10 15

Asn Gly Asn Phe Ala Glu Pro Glu Gln Cys Val Glu Gln Gln Thr Gly
20 25 30

Ala Lys Val His His Leu Pro Ala Ser Ile Trp Lys Arg Lys Met Gly
35 40 45

Lys Ala Lys Ser Pro Leu Asp Val Ala Ile Glu Gly Ser Arg Asp Phe
50 55 60

Phe Phe Gln Glu Gln Leu Pro Lys Gly Tyr Trp Trp Ala Glu Leu Glu
65 70 75 80

Ser Asn Val Thr Ile Thr Ala Glu Tyr Ile Met Leu Phe His Phe Leu
85 90 95

Gly Leu Val Asp Arg Glu Arg Gln Arg Lys Met Ser Asn Tyr Leu Leu
100 105 110

Ser Lys Gln Thr Glu Glu Gly Phe Trp Pro Ile Tyr Tyr Gly Gly Pro
115 120 125

Gly Asp Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys Leu Ser
130 135 140

Gly Tyr Pro Ala Asp His Pro Ala Leu Ala Lys Ala Arg Ala Phe Ile
145 150 155 160

Leu Glu Gln Gly Gly Val Val Lys Ser Arg Val Phe Thr Lys Ile Phe
165 170 175

Leu Ala Leu Phe Gly Glu Phe Glu Trp Gln Gly Val Pro Ser Met Pro
180 185 190

Val Glu Leu Asn Leu Leu Pro Asp Trp Ala Tyr Ile Asn Ile Tyr Glu
195 200 205

Phe Ser Ser Trp Ala Arg Ala Thr Ile Val Pro Leu Ser Val Val Met
210 215 220

His Ser Arg Pro Val Arg Arg Val Pro Pro Ser Ala Arg Val Gln Glu
225 230 235 240

Leu Phe Val Arg Gln Pro Thr Ala Ala Asp Tyr Ser Phe Ala Lys Asn
245 250 255

Asp Gly Ile Phe Thr Trp Glu Asn Phe Phe Leu Gly Leu Asp Arg Val
260 265 270

Leu Lys Val Tyr Glu Lys Ser Pro Leu Arg Pro Phe Lys Asn Met Ala
275 280 285

Leu Ala Lys Ala Glu Glu Trp Val Leu Glu His Gln Glu Pro Thr Gly
290 295 300

Asp Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ala Val Leu Ala Leu
305 310 315 320

Asn Val Leu Gly Tyr Gln Asn Asp His Pro Ala Val Glu Gln Gly Leu
325 330 335

Arg Ala Leu Ala Asn Phe Cys Ile Glu Thr Glu Asp Gln Leu Val Leu
340 345 350

Gln Ser Cys Val Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Lys Ala
355 360 365

Leu Leu Asp Ala Gly Val Pro Pro Asp His Pro Ser Leu Val Lys Gly
370 375 380

Ala Gln Trp Leu Leu Asp Lys Glu Val Thr Arg Pro Gly Asp Trp Arg
385 390 395 400

Val Lys Ser Pro Ala Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu
405 410 415

Asn Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Phe Val Met Ile Ala
420 425 430

Leu Lys Gly Ile Gln Val Lys Asp Arg Lys Ser Met Asp Ala Ala Ile
435 440 445

Lys Arg Gly Ile Asn Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly
450 455 460

Trp Gly Ala Phe Asp Lys Asp Asn Thr Arg His Val Leu Asn Lys Ile
465 470 475 480

Pro Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu
485 490 495

Thr Gly Arg Met Leu Glu Leu Met Gly Thr Phe Asn Tyr Pro Ile Thr
500 505 510

Leu Pro Ala Ala Gln Arg Ala Ile Glu Phe Leu Lys Lys Asn Gln Glu
515 520 525

Pro Glu Gly Pro Trp Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly
530 535 540

Thr Trp Ser Val Leu Cys Gly Leu Ala Ala Ile Gly Glu Asp Met Asp
545 550 555 560

Gln Pro Tyr Ile Arg Lys Ala Val Asn Trp Ile Lys Ser Arg Gln Asn
565 570 575

Ile Asp Gly Gly Trp Gly Glu Thr Cys Gln Ser Tyr His Asp Arg Thr
580 585 590

Leu Ala Gly Val Gly Glu Ser Thr Pro Ser Gln Thr Gly Trp Ala Leu
595 600 605

Leu Gly Leu Leu Ala Ala Gly Glu Met His Ser Ala Thr Val Val Arg
610 615 620

Gly Val Gln Tyr Leu Ile Ser Thr Gln Asn Ser Asp Gly Thr Trp Asp
625 630 635 640

Glu Gln Gln Tyr Thr Gly Thr Gly Phe Pro Lys Tyr Phe Met Ile Lys
645 650 655

Tyr His Ile Tyr Arg Asn Cys Phe Pro Leu Met Ala Leu Gly Thr Tyr
660 665 670

Arg Thr Leu Thr Arg Thr Gln Pro
675 680


<210> 150
<211> 730
<212> PRT
<213> Geobacter sulfurreducens

<400> 150
Met Ala Lys Gly Ile Leu Asn Lys Phe Ala Val Ile Ala Gly Thr Lys
1 5 10 15

Lys Ala Gly Pro Pro Ala Gly Glu Glu Arg Thr Val Ile Ala Pro Ile
20 25 30

Lys Glu Ile Ser Gly Lys Ala Val His Cys Ser Gln Ala Val Lys Lys
35 40 45

Ala Glu Glu Tyr Leu Leu Ala Leu Gln Asn Pro Glu Gly Tyr Trp Val
50 55 60

Phe Glu Leu Glu Ala Asp Val Thr Ile Pro Ser Glu Tyr Ile Met Leu
65 70 75 80

Gln Arg Phe Leu Gly Arg Glu Ile Ser Pro Glu Leu Gly Lys Arg Leu
85 90 95

Glu Asn Tyr Leu Leu Asp Arg Gln Leu Pro Asp Gly Gly Trp Pro Leu
100 105 110

Tyr Ala Glu Asp Gly Phe Ala Asn Ile Ser Ala Thr Val Lys Ala Tyr
115 120 125

Leu Ala Leu Lys Val Leu Gly His Ser Pro Gln Ala Pro His Met Ile
130 135 140

Arg Ala Arg Leu Met Val Leu Ser Leu Gly Gly Ala Ala Arg Cys Asn
145 150 155 160

Val Phe Thr Arg Ile Leu Leu Ala Leu Phe Gly Gln Ile Pro Trp His
165 170 175

Thr Pro Pro Ala Met Pro Val Glu Ile Val Leu Leu Pro Gln Trp Phe
180 185 190

Phe Phe His Leu Ser Lys Val Ser Tyr Trp Ser Arg Thr Val Ile Val
195 200 205

Pro Leu Leu Leu Leu Tyr Ala Lys Gln Pro Val Cys Arg Leu Arg Pro
210 215 220

Glu Glu Gly Ile Pro Glu Leu Phe Ser Thr Pro Pro Asp Lys Leu Arg
225 230 235 240

His Leu Asp Gly Phe Gln Pro Gly Tyr Trp Arg Lys Asn Ala Phe Ile
245 250 255

Ile Phe Asp Arg Leu Leu Lys Arg Phe Asn Arg Phe Ile Pro Ser Ala
260 265 270

Leu His Arg Lys Ala Ile Ala Glu Ala Glu Gln Trp Thr Arg Ser His
275 280 285

Met Gln Gly Ser Gly Gly Ile Gly Ala Ile Phe Pro Ala Met Ala Tyr
290 295 300

Ala Val Met Ala Leu Arg Val Leu Gly Cys Gly Glu Gly Asp Pro Asp
305 310 315 320

Tyr Ile Arg Gly Leu Gln Ala Ile Asp Asp Leu Leu Gln His Arg Thr
325 330 335

Pro Gln Glu Ala Asp Pro Pro Arg Thr Asp Gly Thr Cys Ile Asp Ser
340 345 350

Gly Met Ser Ala Ala Phe Ala Leu Thr Pro Ser Ala His Ala Ala Ala
355 360 365

Asp Gly Thr Gly Ser Ser Ser Ile Cys Gln Pro Cys Asn Ser Pro Ile
370 375 380

Trp Asp Thr Cys Leu Ser Leu Ser Ala Leu Met Glu Ala Gly Met Pro
385 390 395 400

Ala Ser His Pro Ala Ala Thr Gln Ala Val Glu Trp Leu Leu Ser Gln
405 410 415

Gln Ile Leu Ser Pro Gly Asp Trp Ser Leu Lys Val Pro Asp Leu Glu
420 425 430

Gly Gly Gly Trp Ala Phe Gln Phe Glu Asn Thr Leu Tyr Pro Asp Leu
435 440 445

Asp Asp Thr Ser Lys Val Ile Met Ser Leu Leu Arg Ala Gly Ala Leu
450 455 460

Glu Asn Glu Arg Tyr Arg Asp Arg Ile Ala Arg Gly Val Asn Trp Val
465 470 475 480

Leu Gly Met Gln Ser Ser Asp Gly Gly Trp Ala Ala Phe Asp Ile Asp
485 490 495

Asn Asn Tyr His Tyr Leu Asn Asp Ile Pro Phe Ala Asp His Gly Ala
500 505 510

Leu Leu Asp Pro Ser Thr Ser Asp Leu Thr Gly Arg Cys Ile Glu Leu
515 520 525

Leu Ser Met Val Gly Phe Asp Arg Thr Phe Pro Pro Ile Ala Arg Gly
530 535 540

Ile Gly Phe Leu Arg Ser Glu Gln Glu Glu Asn Gly Ala Trp Phe Gly
545 550 555 560

Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Ser Gly
565 570 575

Leu Arg Gln Ala Gly Glu Asp Met Gln Gln Pro Tyr Ile Arg Lys Ala
580 585 590

Val Gly Trp Leu Ala Ser Cys Gln Asn His Asp Gly Gly Trp Gly Glu
595 600 605

Thr Cys Tyr Ser Tyr Asp Asp Pro Ser Leu Ala Gly Lys Gly Ala Ser
610 615 620

Thr Pro Ser Gln Thr Ala Trp Ser Leu Leu Gly Leu Met Ala Ala Gly
625 630 635 640

Glu Val Asn Ser Leu Ala Val Arg Arg Gly Val Arg Tyr Leu Leu Asp
645 650 655

His Gln Asn Gln Trp Gly Thr Trp Glu Glu Lys His Phe Thr Gly Thr
660 665 670

Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg His Phe
675 680 685

Phe Pro Leu Trp Ala Leu Gly Val Tyr Ser Arg Leu Ser Ser Gly Gln
690 695 700

Lys Ala Cys Gln Asp Glu Arg Arg His Ala Ser Pro Gly Asp Leu His
705 710 715 720

Leu Pro Trp Leu Glu Arg Ile Lys Lys Arg
725 730


<210> 151
<211> 679
<212> PRT
<213> Geobacter sulfurreducens

<400> 151
Met Lys Ile Ser Lys Asn Pro Ile Ser His Ala Leu Thr Ser Phe Asn
1 5 10 15

Asp Ala Ala Arg Glu Thr Ala Asp Asn Ser Ala Ala Arg Lys Ser Gly
20 25 30

Lys Ile His His Leu Pro Ala Thr Ile Trp Lys Lys Lys Glu Ser Thr
35 40 45

Val Ser Ser Pro Leu Asp Ile Ala Ile Glu Arg Thr Gln Glu Phe Phe
50 55 60

Phe Arg Glu Gln Leu Pro Ala Gly Tyr Trp Trp Ala Glu Leu Glu Ser
65 70 75 80

Asn Ala Thr Ile Thr Ala Glu Tyr Ile Met Leu Phe His Phe Met Gly
85 90 95

Leu Val Asn Arg Glu Lys Glu Arg Lys Met Ala Asn Tyr Leu Leu Arg
100 105 110

Gln Gln Thr Thr Glu Gly Tyr Trp Thr Ile Trp His Gly Gly Pro Gly
115 120 125

Asp Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys Leu Ala Gly
130 135 140

Tyr Pro Ala Asp His Pro Ser Met Ser Lys Ala Arg Ala Phe Ile Leu
145 150 155 160

Glu His Gly Gly Ile Leu Lys Ala Arg Val Phe Thr Lys Ile Phe Leu
165 170 175

Ala Leu Phe Gly Glu Phe Ser Trp Leu Gly Val Pro Ser Met Pro Ile
180 185 190

Glu Met Met Leu Leu Pro Ala Gly Phe Thr Phe Asn Met Tyr Glu Phe
195 200 205

Ser Ser Trp Ser Arg Ala Thr Ile Ile Pro Leu Ser Ile Val Met Ala
210 215 220

Glu Arg Pro Val Arg Lys Leu Pro Pro Trp Ala Arg Val Gln Glu Leu
225 230 235 240

Tyr Val Arg Pro Pro Arg Pro Thr Asp Tyr Thr Phe Thr Lys Glu Asp
245 250 255

Gly Ile Leu Thr Trp Lys Asn Ile Phe Ile Gly Ile Asp His Val Leu
260 265 270

Lys Val Tyr Glu Ala Ser Pro Ile Arg Pro Gly Arg Lys Lys Ala Met
275 280 285

Ala Ile Ala Glu Lys Trp Val Leu Glu His Gln Glu Pro Thr Gly Asp
290 295 300

Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ser Val Leu Ala Leu His
305 310 315 320

Val Leu Gly Tyr Ala Asn Asp His Pro Ala Val Ala Lys Gly Leu Gln
325 330 335

Ala Leu Ala Asn Phe Cys Ile Glu Gly Glu Asp Glu Leu Val Leu Gln
340 345 350

Ser Cys Val Ser Pro Val Trp Asp Thr Ala Leu Gly Leu Met Ala Met
355 360 365

Val Asp Ser Gly Val Pro Thr Asp His Pro Ser Leu Ser Lys Ala Ala
370 375 380

Gln Trp Leu Leu Asp Arg Glu Val Arg Arg Pro Gly Asp Trp Lys Ile
385 390 395 400

Lys Cys Pro Asp Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Met Asn
405 410 415

Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Ile Val Met Met Ala Ile
420 425 430

Lys Asn Val Lys Val Lys Asp Gln Arg Ala Lys Glu Asp Thr Ile Thr
435 440 445

Arg Gly Ile Ala Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Trp
450 455 460

Gly Ala Phe Asp Lys Asp Asn Thr Lys His Ile Leu Asn Lys Ile Pro
465 470 475 480

Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr
485 490 495

Gly Arg Met Leu Glu Leu Met Gly Thr Tyr Gly Tyr Pro Lys Asp His
500 505 510

Pro Ala Ala Val Arg Ala Leu Lys Phe Ile Arg Glu Thr Gln Glu Pro
515 520 525

Asp Gly Pro Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr
530 535 540

Trp Ser Val Met Ser Gly Leu Ala Ala Phe Gly Glu Asp Met Ser Gln
545 550 555 560

Pro Trp Ile Arg Lys Ala Val Asp Trp Leu Val Glu His Gln Asn Glu
565 570 575

Asp Gly Gly Trp Gly Glu Cys Cys Glu Ser Tyr Ala Asp Pro Arg Leu
580 585 590

Ala Gly Val Gly Pro Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Leu
595 600 605

Thr Leu Leu Ala Ala Gly Glu Val Ala Ser Ser Ser Val Val Arg Gly
610 615 620

Val Gln Tyr Leu Leu Asp Thr Gln Lys Pro Asp Gly Thr Trp Asp Glu
625 630 635 640

Asp Ala Phe Thr Gly Thr Gly Phe Pro Lys Phe Phe Met Ile Lys Tyr
645 650 655

His Ile Tyr Arg Asn Cys Phe Pro Leu Met Ala Leu Gly Arg Tyr Arg
660 665 670

Thr Leu Ala Gly Lys Gly Leu
675


<210> 152
<211> 679
<212> PRT
<213> Geobacter uraniireducens

<400> 152
Met Asn Ser Cys Lys His Pro Ile Ser His Ala Leu Thr Ser Phe Asn
1 5 10 15

Gly Glu Thr Ala Asp Ala Ala Lys Lys Gln Pro Val Lys Pro Gly Ala
20 25 30

Lys Ile His His Leu Pro Ala Ser Ile Trp Lys Lys Lys Glu Gly Glu
35 40 45

Ser Lys Ser Pro Leu Asp Ile Ala Ile Glu Asn Ser Arg Asp Phe Phe
50 55 60

Phe Arg Glu Gln Leu Pro Asp Gly Tyr Trp Trp Ala Glu Leu Glu Ser
65 70 75 80

Asn Cys Thr Ile Thr Ala Glu Tyr Leu Met Leu Tyr His Phe Met Gly
85 90 95

Ile Val Asp Gln Glu Arg Glu Arg Lys Met Ala Thr Tyr Leu Leu Ser
100 105 110

Lys Gln Thr Ala Glu Gly Phe Trp Thr Ile Tyr Phe Gly Gly Pro Gly
115 120 125

Asp Leu Ser Thr Thr Val Glu Ala Tyr Phe Ala Leu Lys Leu Ala Gly
130 135 140

Tyr Pro Ala Asp His Pro Ala Met Ala Lys Ala Arg Ala Phe Ile Leu
145 150 155 160

Asp Asn Gly Gly Ile Ile Lys Cys Arg Val Phe Thr Lys Ile Phe Leu
165 170 175

Ala Leu Phe Gly Glu Phe Ala Trp Phe Gly Val Pro Ser Met Pro Ile
180 185 190

Glu Leu Ile Leu Leu Pro Asn Trp Ala Tyr Phe Asn Met Tyr Glu Leu
195 200 205

Ser Ser Trp Ser Arg Ala Thr Ile Ile Pro Leu Ser Ile Val Met Thr
210 215 220

Glu Arg Pro Val Arg Lys Leu Pro Pro Ser Ser Arg Val Gln Glu Leu
225 230 235 240

Tyr Val Arg Pro Pro Arg Pro Ile Asp Tyr Thr Phe Ser Lys Glu Asp
245 250 255

Gly Ile Ile Thr Trp Lys Asn Phe Phe Ile Gly Val Asp His Ile Leu
260 265 270

Lys Val Tyr Glu Ser Asn Pro Ile Arg Pro Phe Lys Lys Arg Ala Leu
275 280 285

Ala Thr Ala Glu Asn Trp Val Leu Asp His Gln Glu Ser Thr Gly Asp
290 295 300

Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ser Val Leu Ala Leu His
305 310 315 320

Cys Leu Gly Tyr Ala Asn Asp His Pro Ala Val Ala Lys Gly Leu Glu
325 330 335

Ala Leu Ala Asn Phe Cys Ile Glu Thr Glu Asp Ser Leu Val Leu Gln
340 345 350

Ser Cys Ile Ser Pro Ile Trp Asp Thr Ala Leu Ala Leu Lys Ala Leu
355 360 365

Val Asp Ser Asp Val Pro Thr Asp His Pro Ala Leu Val Lys Ala Ala
370 375 380

Gln Trp Leu Leu Asp Lys Glu Val Arg Lys Pro Gly Asp Trp Lys Ile
385 390 395 400

Lys Cys Pro Glu Leu Glu Ser Gly Gly Trp Ala Phe Glu Phe Leu Asn
405 410 415

Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Phe Val Met Met Ala Leu
420 425 430

Lys Asp Val Ala Val Lys Asp Arg Lys Ser Met Asp Gly Ala Ile Lys
435 440 445

Arg Gly Ile Asn Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Trp
450 455 460

Gly Ala Phe Asp Lys Asp Asn Thr Lys Tyr Leu Leu Asn Lys Ile Pro
465 470 475 480

Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr
485 490 495

Gly Arg Met Leu Glu Leu Met Gly Thr Phe Gly Tyr Ser Lys Asp Tyr
500 505 510

Pro Ala Ala Val Arg Ala Leu Glu Phe Ile Lys Lys Asn Gln Glu Pro
515 520 525

Glu Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr
530 535 540

Trp Ser Val Leu Gly Gly Leu Ala Ala Ile Gly Glu Asp Leu Asn Gln
545 550 555 560

Pro Tyr Ile Arg Lys Ala Val Asn Trp Leu Lys Ser Arg Gln Asn Met
565 570 575

Asp Gly Gly Trp Gly Glu Thr Cys Glu Ser Tyr His Asp Thr Ser Leu
580 585 590

Ala Gly Ile Gly Glu Ser Thr Pro Ser Gln Thr Gly Trp Ala Leu Leu
595 600 605

Ser Leu Met Ser Ala Gly Glu Ala Asn Ser Ser Thr Val Ala Arg Gly
610 615 620

Ile Gln Tyr Leu Ile Ala Asn Gln Lys Ser Asp Gly Thr Trp Asp Glu
625 630 635 640

Glu Gln Tyr Thr Gly Thr Gly Phe Pro Lys Phe Phe Met Ile Lys Tyr
645 650 655

His Ile Tyr Arg Asn Cys Phe Pro Leu Thr Ala Leu Gly Thr Tyr Arg
660 665 670

Lys Leu Thr Gly Gly Met Ala
675


<210> 153
<211> 637
<212> PRT
<213> Gloeobacter violaceus

<400> 153
Met Gln Val Gln Pro Arg Ile Glu Lys Lys His Leu Asp Ser Ala Ile
1 5 10 15

Glu Ala Ser Gln Ala Tyr Leu Leu Ala Arg Gln Tyr Ser Pro Gly Tyr
20 25 30

Trp Trp Ala Glu Leu Glu Ser Asn Val Ser Met Thr Ala Glu Val Val
35 40 45

Leu Leu His Lys Ile Trp Arg Thr Asp Thr Gly Arg Pro Leu Ala Lys
50 55 60

Ala Thr Ala His Leu Leu Ala Glu Gln Arg Ala His Gly Gly Trp Glu
65 70 75 80

Leu Phe Tyr Gly Asp Gly Gly Asp Leu Asn Thr Ser Ile Glu Ala Tyr
85 90 95

Met Ala Leu Lys Leu Leu Gly Leu Thr Ala Asp His Pro Ala Leu Ala
100 105 110

Arg Ala Arg Ala Phe Ile Leu Ala Lys Gly Gly Ile Ser Arg Ala Arg
115 120 125

Ile Phe Thr Lys Ile His Leu Ala Leu Ile Gly Cys Tyr Asp Trp Arg
130 135 140

Gly Val Pro Ser Ile Pro Pro Trp Val Met Leu Leu Pro Glu Ala Phe
145 150 155 160

Pro Val Asn Ile Tyr Glu Met Ser Ser Trp Ala Arg Gly Ser Thr Val
165 170 175

Pro Leu Leu Ile Val Phe Asp Arg Lys Pro Val Phe Ala Val Glu Pro
180 185 190

Ala Ile Thr Leu Asp Glu Leu Phe Val Glu Gly Arg Ala Gln Ala Arg
195 200 205

Phe Asp Leu Pro Arg Ser Ser Ser Asp Trp Trp Ala Asn Leu Phe Val
210 215 220

Asp Leu Asp Trp Gly Phe Lys Leu Ala Glu Ser Leu Gly Ala Val Pro
225 230 235 240

Leu Arg Glu Glu Gly Leu Lys Ala Ala Glu Arg Trp Val Leu Glu Arg
245 250 255

Gln Glu Ala Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn
260 265 270

Ser Leu Leu Ala Leu Arg Cys Leu Asp Tyr Asp Pro His Asp Pro Val
275 280 285

Val Glu Arg Gly Met Ala Ala Val Asp Arg Phe Ala Ile Glu Thr Glu
290 295 300

Ser Thr Tyr Arg Leu Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala
305 310 315 320

Leu Thr Met Arg Ala Leu Val Asp Ser Gly Leu Pro Pro Asp His Pro
325 330 335

Ala Leu Ala Ala Ala Gly Thr Trp Leu Leu Lys Lys Gln Ile Leu Asp
340 345 350

Tyr Gly Asp Trp Ala Val Lys Asn Arg Thr Gly Pro Pro Gly Gly Trp
355 360 365

Ala Phe Glu Phe Asp Asn Arg Phe Tyr Pro Asp Val Asp Asp Thr Ala
370 375 380

Val Val Val Met Ala Leu Asp Ala Val Arg Leu Ala Asp Glu Thr Ala
385 390 395 400

Lys Gly Gln Ala Ile Ala Arg Ala Val Cys Trp Val Ala Ser Met Gln
405 410 415

Cys Arg Gly Gly Gly Trp Ala Ala Phe Asp Ile Asp Asn Asp Ala His
420 425 430

Trp Leu Asn Ser Leu Pro Tyr Ala Asp Leu Lys Ala Met Ile Asp Pro
435 440 445

Asn Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met Tyr Gly Arg Cys
450 455 460

Arg Leu Ile Pro Ala Ala Ala Gly Ala Gln Arg Ala Leu Asp Tyr Leu
465 470 475 480

Arg Arg Thr Gln Glu Pro Glu Gly Cys Trp Phe Gly Arg Trp Gly Val
485 490 495

Asn Tyr Leu Tyr Gly Thr Ser Gly Val Leu Ser Ala Leu Ala Ala Phe
500 505 510

Ala Pro Ala Glu Arg Thr Ala Ile Glu Arg Ala Ala Ala Trp Leu Arg
515 520 525

Gly Cys Gln Asn Thr Asp Gly Gly Trp Gly Glu Thr Cys Gly Ser Tyr
530 535 540

Val Asp Arg Thr Leu Met Gly Gln Gly Pro Ser Thr Ala Ser Gln Thr
545 550 555 560

Ala Trp Ala Leu Leu Gly Leu Ile Asp Ala Ser Arg Val Ala Arg Phe
565 570 575

Ser Asp Ser Ser Ala Leu Glu Arg Gly Leu Ala Tyr Leu Val Glu Thr
580 585 590

Gln Lys Ala Asp Gly Ser Trp Asp Glu Pro Tyr Phe Thr Gly Thr Gly
595 600 605

Phe Pro Gly His Phe Tyr Leu Lys Tyr His Leu Tyr Gln Gln His Phe
610 615 620

Pro Leu Ser Ala Leu Gly Arg Tyr Arg Arg Leu Leu Ser
625 630 635


<210> 154
<211> 663
<212> PRT
<213> Gluconacetobacter diazotrophicus

<400> 154
Met Met Ala Asn Ala Thr Asp Thr Ile Glu Leu Pro Pro Ser Arg Ala
1 5 10 15

Ala Asp Arg Ile Val Pro Met Thr Asp Ile Asp Gln Ala Val Asp Ala
20 25 30

Ala His Ala Ala Leu Gly Arg Arg Gln Gln Asp Asp Gly His Trp Val
35 40 45

Phe Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu Leu
50 55 60

Glu His Tyr Leu Asp Arg Ile Asp Pro Ala Leu Glu Glu Arg Ile Gly
65 70 75 80

Val Tyr Leu Arg Arg Ile Gln Gly Asp His Gly Gly Trp Pro Leu Tyr
85 90 95

His Gly Gly Lys Phe Asp Val Ser Ala Thr Val Lys Ala Tyr Phe Ala
100 105 110

Leu Lys Ala Ile Gly Asp Asp Ile Asp Ala Pro His Met Ala Arg Ala
115 120 125

Arg Ala Ala Ile Leu Asp His Gly Gly Ala Glu Arg Ser Asn Val Phe
130 135 140

Thr Arg Phe Gln Leu Ala Leu Phe Gly Glu Val Pro Trp His Ala Thr
145 150 155 160

Pro Val Met Pro Val Glu Leu Met Leu Leu Pro Arg Lys Ala Leu Phe
165 170 175

Ser Val Trp Asn Met Ser Tyr Trp Ser Arg Thr Val Ile Ala Pro Leu
180 185 190

Leu Val Leu Ala Ala Leu Arg Pro Arg Ala Ile Asn Pro Arg Asp Val
195 200 205

His Val Pro Glu Leu Phe Val Thr Pro Pro Asp Gln Val Arg Asp Trp
210 215 220

Ile Arg Gly Pro Tyr Arg Ser Gln Leu Gly Arg Leu Phe Lys Tyr Val
225 230 235 240

Asp Ile Ala Leu Arg Pro Ala Glu Arg Leu Ile Pro Asp Ala Thr Arg
245 250 255

Gln Arg Ala Ile Lys Ala Ala Val Asp Phe Ile Glu Pro Arg Leu Asn
260 265 270

Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Asn Thr Val
275 280 285

Met Met Tyr Arg Ala Leu Gly Val Pro Asp Ser Asp Pro Arg Ala Ala
290 295 300

Thr Ala Trp Glu Ala Val Arg Arg Leu Leu Val Glu Leu Asp Gly Glu
305 310 315 320

Ala Tyr Cys Gln Pro Cys Val Ser Pro Ile Trp Asp Thr Gly Leu Ala
325 330 335

Gly His Ala Met Ile Glu Ala Ala Ser Gly Pro Glu Gly Ile Arg Pro
340 345 350

Glu Asp Thr Lys Lys Lys Leu Ala Ala Ala Ala Glu Trp Leu Arg Glu
355 360 365

Arg Gln Ile Leu Asn Val Lys Gly Asp Trp Ala Ile Asn Cys Pro Asp
370 375 380

Val Pro Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Asp Tyr Tyr Pro
385 390 395 400

Asp Val Asp Asp Thr Ala Val Val Gly Met Leu Leu His Arg Glu Gly
405 410 415

Asp Pro Ala Asn Asp Glu Ala Leu Glu Arg Ala Arg Gln Trp Ile Ile
420 425 430

Gly Met Gln Ser Ser Asn Gly Gly Trp Gly Ala Phe Asp Ile Asp Asn
435 440 445

Asn Leu Asp Phe Leu Asn His Ile Pro Phe Ala Asp His Gly Ala Leu
450 455 460

Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Cys Ile Ser Phe Leu
465 470 475 480

Ala Gln Leu Gly His Pro Glu Asp Arg Pro Val Ile Glu Arg Gly Ile
485 490 495

Ala Tyr Leu Arg Thr Asp Gln Glu Arg Glu Gly Cys Trp Phe Gly Arg
500 505 510

Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala Tyr
515 520 525

Asn Ala Ala Gly Val Ala His Asp Asp Pro Ser Val Val Arg Ala Val
530 535 540

Asp Trp Leu Arg Ser Val Gln Arg Glu Asp Gly Gly Trp Gly Glu Asp
545 550 555 560

Cys Ala Ser Tyr Glu Gly Ala Thr Pro Gly Ile Tyr Thr Glu Ser Leu
565 570 575

Pro Ser Gln Thr Ala Trp Ala Val Leu Gly Leu Met Ala Val Gly Leu
580 585 590

Arg Asp Asp Pro Ala Val Met Arg Gly Met Ala Tyr Leu Thr Arg Thr
595 600 605

Gln Lys Asp Asp Gly Glu Trp Asp Glu Glu Pro Tyr Asn Ala Val Gly
610 615 620

Phe Pro Lys Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Gln Phe Phe
625 630 635 640

Pro Leu Leu Ala Leu Ser Arg Tyr Arg Asn Leu Ala Ser Ser Asn Ser
645 650 655

Arg His Val Ala Phe Gly Phe
660


<210> 155
<211> 663
<212> PRT
<213> Gluconacetobacter diazotrophicus

<400> 155
Met Met Ala Asn Ala Thr Asp Thr Ile Glu Leu Pro Pro Ser Arg Ala
1 5 10 15

Ala Asp Arg Ile Val Pro Met Thr Asp Ile Asp Gln Ala Val Asp Ala
20 25 30

Ala His Ala Ala Leu Gly Arg Arg Gln Gln Asp Asp Gly His Trp Val
35 40 45

Phe Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu Leu
50 55 60

Glu His Tyr Leu Asp Arg Ile Asp Pro Ala Leu Glu Glu Arg Ile Gly
65 70 75 80

Val Tyr Leu Arg Arg Ile Gln Gly Asp His Gly Gly Trp Pro Leu Tyr
85 90 95

His Gly Gly Lys Phe Asp Val Ser Ala Thr Val Lys Ala Tyr Phe Ala
100 105 110

Leu Lys Ala Ile Gly Asp Asp Ile Asp Ala Pro His Met Ala Arg Ala
115 120 125

Arg Ala Ala Ile Leu Asp His Gly Gly Ala Glu Arg Ser Asn Val Phe
130 135 140

Thr Arg Phe Gln Leu Ala Leu Phe Gly Glu Val Pro Trp His Ala Thr
145 150 155 160

Pro Val Met Pro Val Glu Leu Met Leu Leu Pro Arg Lys Ala Leu Phe
165 170 175

Ser Val Trp Asn Met Ser Tyr Trp Ser Arg Thr Val Ile Ala Pro Leu
180 185 190

Leu Val Leu Ala Ala Leu Arg Pro Arg Ala Ile Asn Pro Arg Asp Val
195 200 205

His Val Pro Glu Leu Phe Val Thr Pro Pro Asp Gln Val Arg Asp Trp
210 215 220

Ile Arg Gly Pro Tyr Arg Ser Gln Leu Gly Arg Leu Phe Lys Tyr Val
225 230 235 240

Asp Ile Ala Leu Arg Pro Ala Glu Arg Leu Ile Pro Asp Ala Thr Arg
245 250 255

Gln Arg Ala Ile Lys Ala Ala Val Asp Phe Ile Glu Pro Arg Leu Asn
260 265 270

Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Asn Thr Val
275 280 285

Met Met Tyr Arg Ala Leu Gly Val Pro Asp Ser Asp Pro Arg Ala Ala
290 295 300

Thr Ala Trp Glu Ala Val Arg Arg Leu Leu Val Glu Leu Asp Gly Glu
305 310 315 320

Ala Tyr Cys Gln Pro Cys Val Ser Pro Ile Trp Asp Thr Gly Leu Ala
325 330 335

Gly His Ala Met Ile Glu Ala Ala Ser Gly Pro Lys Gly Ile Arg Pro
340 345 350

Glu Asp Thr Lys Lys Lys Leu Ala Ala Ala Ala Glu Trp Leu Arg Glu
355 360 365

Arg Gln Ile Leu Asn Gly Glu Gly Arg Leu Gly Asp Gln Leu Pro Arg
370 375 380

Arg Ala Pro Arg Arg Leu Gly Leu Pro Val Gln Gln Arg Leu Leu Pro
385 390 395 400

Arg Arg Gly Arg His Gly Ser Gly Arg His Val Leu His Arg Glu Gly
405 410 415

Asp Pro Ala Asn Asp Glu Ala Leu Glu Arg Ala Arg Gln Trp Ile Ile
420 425 430

Gly Met Gln Ser Ser Asn Gly Gly Trp Gly Ala Phe Asp Ile Asp Asn
435 440 445

Asn Leu Asp Phe Leu Asn His Ile Pro Phe Ala Asp His Gly Ala Leu
450 455 460

Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Cys Ile Ser Phe Leu
465 470 475 480

Ala Gln Leu Gly His Pro Glu Asp Arg Pro Val Ile Glu Arg Gly Ile
485 490 495

Ala Tyr Leu Arg Thr Asp Gln Glu Arg Glu Gly Cys Trp Phe Gly Arg
500 505 510

Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala Tyr
515 520 525

Asn Ala Ala Gly Val Ala His Asp Asp Pro Ser Val Val Arg Ala Val
530 535 540

Asp Trp Leu Arg Ser Val Gln Arg Glu Asp Gly Gly Trp Gly Glu Asp
545 550 555 560

Cys Ala Ser Tyr Glu Gly Ala Thr Pro Gly Ile Tyr Thr Glu Ser Leu
565 570 575

Pro Ser Gln Thr Ala Trp Ala Val Leu Gly Leu Met Ala Val Gly Leu
580 585 590

Arg Asp Asp Pro Ala Val Met Arg Gly Met Ala Tyr Leu Thr Arg Thr
595 600 605

Gln Lys Asp Asp Gly Glu Trp Asp Glu Glu Pro Tyr Asn Ala Val Gly
610 615 620

Phe Pro Lys Val Phe Tyr Leu Arg Tyr His Gly Tyr Arg Gln Phe Phe
625 630 635 640

Pro Leu Leu Ala Leu Ser Arg Tyr Arg Asn Leu Ala Ser Ser Asn Ser
645 650 655

Arg His Val Ala Phe Gly Phe
660


<210> 156
<211> 664
<212> PRT
<213> Gluconobacter oxydans

<400> 156
Met Leu Ile Tyr Ser Asp Ile Leu Glu Lys Glu Asp Arg Val Ser Glu
1 5 10 15

Thr Leu Ser Arg Gln Ser Val Glu Pro Asp Glu Ile Asn His Ala Ile
20 25 30

Glu Gly Ala Gln Ala Ala Leu Gly Gly Lys Gln Lys Ser Asp Gly His
35 40 45

Trp Val Tyr Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val
50 55 60

Leu Leu Glu His Tyr Leu Asp Arg Ile Asp Pro Glu Lys Gln Ala Lys
65 70 75 80

Ile Gly Val Tyr Leu Arg Arg Ile Gln Gly His His Gly Gly Trp Pro
85 90 95

Leu Tyr His Asp Gly Gly Phe Asp Leu Ser Ala Thr Val Lys Ala Tyr
100 105 110

Phe Ala Leu Lys Ala Ile Gly Asp Asp Ile Asn Ala Pro His Met Arg
115 120 125

Ile Ala Arg Glu Ala Ile Leu Asp His Gly Gly Ala Ala Arg Thr Asn
130 135 140

Val Phe Thr Arg Ile Gln Leu Ala Leu Phe Gly Glu Val Pro Trp Asp
145 150 155 160

Ala Thr Pro Val Met Pro Val Glu Leu Met Leu Leu Pro Arg Lys Ala
165 170 175

Phe Phe Ser Val Trp Asn Met Ser Tyr Trp Ser Arg Ala Val Ile Ala
180 185 190

Pro Leu Leu Val Leu Asn Ala Leu Arg Pro Lys Ala Ile Asn Pro Arg
195 200 205

Gly Ile His Val Gln Glu Leu Phe Val Lys Pro Pro Ser Glu Val Lys
210 215 220

Asp Trp Ile Arg Gly Pro Tyr Arg Ser Val Trp Gly Arg Phe Phe Lys
225 230 235 240

His Leu Asp Ser Ala Leu Arg Pro Val Leu Pro Leu Ile Pro Arg Ser
245 250 255

Val His Lys Lys Ala Leu Lys Ala Ala Ser Asp Phe Ile Glu Pro Arg
260 265 270

Leu Ser Arg Gly Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Asn Val
275 280 285

Val Met Met Tyr Arg Ala Gln Gly Val Pro Asp Ser Asp Pro Arg Ala
290 295 300

Lys Thr Ala Trp Asp Ala Ile Gln Asp Leu Leu Val Asp His Gly Asp
305 310 315 320

Glu Ile Tyr Cys Gln Pro Cys Val Ser Pro Val Trp Asp Thr Gly Leu
325 330 335

Ser Gly Leu Ala Met Ile Glu Ala Ala Ser Gly Pro Ala Gly Thr Lys
340 345 350

Thr Lys Glu Thr Leu Ala Ala Leu Lys Lys Ser Ala Glu Trp Leu Arg
355 360 365

Glu His Gln Ile Leu Asp Val Lys Gly Asp Trp Ala Ile Asn Ala Pro
370 375 380

Asp Leu Arg Pro Gly Gly Trp Ala Phe Gln Tyr Glu Asn Asp Tyr Tyr
385 390 395 400

Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Leu Leu His Arg Val
405 410 415

Asp Pro Glu Asn Ser Arg Glu Ala Ile Ser Arg Ala Arg Glu Trp Ile
420 425 430

Ile Gly Met Gln Ser Thr Asn Gly Gly Trp Gly Ala Phe Asp Ile Asp
435 440 445

Asn Asp His Glu Leu Leu Asn His Ile Pro Phe Ser Asp His Gly Ala
450 455 460

Leu Leu Asp Pro Pro Thr Ala Asp Val Ser Ala Arg Cys Ile Ser Phe
465 470 475 480

Leu Ala Gln Leu Gly Asp Pro Asp Asp Arg Pro Val Ile Leu Lys Ala
485 490 495

Ile Glu Tyr Leu Arg Ser Glu Gln Glu Pro Glu Gly Cys Trp Phe Gly
500 505 510

Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala
515 520 525

Leu Asn Ile Ala Gly Val Pro His Asp Asp Pro Met Val Leu Arg Ala
530 535 540

Val Asn Trp Leu Glu Ser Val Gln Arg Pro Asp Gly Gly Trp Gly Glu
545 550 555 560

Asp Cys Ala Thr Tyr Glu Gly Gly Thr Ala Gly Thr Tyr Lys Lys Ser
565 570 575

Leu Pro Ser Gln Thr Ala Trp Ala Val Leu Ala Leu Met Ala Val Gly
580 585 590

Arg Arg Glu Ser Glu Ala Val Lys Arg Gly Val Ala Tyr Leu Val Ser
595 600 605

Gln Gln Asn Glu Lys Gly Glu Trp Gln Glu Glu Ala Tyr Asn Ala Val
610 615 620

Gly Phe Pro Lys Val Phe Tyr Leu Arg Tyr His Gly Tyr Lys Gln Phe
625 630 635 640

Phe Pro Leu Thr Ala Leu Ala Arg Tyr Arg Asn Leu Gly Val Ser Asn
645 650 655

Ser Gly Lys Val Glu Tyr Gly Phe
660


<210> 157
<211> 651
<212> PRT
<213> Granulibacter bethesdensis

<400> 157
Met Pro Lys Asp Ile Pro Ala Asp Leu Ala Ser Glu Ala Ile Ser Gly
1 5 10 15

Asp Met Leu Glu Gln Ala Val Leu Arg Ala Ser Met Ala Leu His Arg
20 25 30

Lys Gln Gln Thr Asp Gly His Trp Val Phe Glu Leu Glu Ala Asp Ala
35 40 45

Thr Ile Pro Ala Glu Tyr Val Leu Leu Glu His Phe Leu Asp Arg Ile
50 55 60

Asp Asp Asp Leu Glu Arg Lys Ile Gly Val Tyr Leu Arg Arg Ile Gln
65 70 75 80

Gly Asp His Gly Gly Trp Pro Leu Phe His Glu Gly Ala Phe Asn Leu
85 90 95

Ser Ala Ser Val Lys Ala Tyr Tyr Ala Leu Lys Ala Ile Gly Asp Asp
100 105 110

Pro Asp Ala Pro His Met Arg Arg Ala Arg Glu Ala Ile Leu Ala Ala
115 120 125

Gly Gly Ala Glu Arg Ser Asn Val Phe Thr Arg Ile Gln Leu Ala Leu
130 135 140

Phe Gly Gln Ile Pro Trp Arg Gly Val Pro Val Met Pro Ala Glu Leu
145 150 155 160

Met Ile Ala Pro Lys Trp Phe Pro Ile Asn Met Trp Lys Val Ser Tyr
165 170 175

Trp Ser Arg Thr Val Ile Ala Pro Leu Leu Val Leu Met Asp Arg Lys
180 185 190

Pro Lys Ala Arg Asn Pro Arg Asn Val His Val Arg Glu Leu Phe Leu
195 200 205

His Asp Pro Asp Arg Ile Arg Asp Trp Ile Arg Gly Pro Phe Arg Ser
210 215 220

Gly Trp Gly His Phe Phe Lys Tyr Leu Asp Ser Val Leu Arg Val Val
225 230 235 240

Glu Pro Val Ala Leu Lys Pro Met Arg Pro Arg Ser Ile Arg Leu Ala
245 250 255

Val Asp Phe Val Arg Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala
260 265 270

Ile Tyr Pro Ala Met Ala Asn Ser Val Met Met Tyr Asp Val Leu Gly
275 280 285

Tyr Ser Pro Asp His Pro Glu Ala Ala Ile Ala Trp Glu Ser Val Arg
290 295 300

Lys Leu Leu Val Ile Lys Glu Asp Glu Ala Tyr Cys Gln Pro Cys Leu
305 310 315 320

Ser Pro Ile Trp Asp Thr Gly Leu Ser Gly His Ala Met Ala Glu Ala
325 330 335

Glu Gly Ala Val Ser Pro Gly Val Ala Ala Ala Cys Asp Trp Leu Arg
340 345 350

Asn Arg Gln Ile Thr Asp Val Val Gly Asp Trp Ala Glu Ile Arg Pro
355 360 365

Gly Val Gln Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala His Tyr
370 375 380

Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Leu Leu His Arg Gln
385 390 395 400

Gly Asp Pro Ala His Glu Glu Ser Ile Arg Lys Ala Arg Glu Trp Ile
405 410 415

Ile Gly Leu Gln Cys Arg Asp Gly Gly Trp Gly Ala Phe Asp Ala Asp
420 425 430

Asn Asp Lys Asp Tyr Leu Asn His Ile Pro Phe Ala Asp His Gly Ala
435 440 445

Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Cys Ile Ser Phe
450 455 460

Leu Ala Gln Leu Gly Asn Pro Glu Asp Lys Pro Val Ile Asp Arg Ala
465 470 475 480

Met Ala Trp Leu Arg Lys Glu Gln Glu Ala Asp Gly Ser Trp Phe Gly
485 490 495

Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala
500 505 510

Met Asn Val Ala Gly Met Pro His Asp Asp Pro Ala Ile Arg Arg Ala
515 520 525

Val Asn Phe Leu Val Ala Thr Gln Arg Glu Asp Gly Gly Trp Gly Glu
530 535 540

Asp Glu Glu Thr Tyr Asp Pro Ala Ser Gly Ala Gln Pro Gly Arg Tyr
545 550 555 560

Lys Glu Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Ile Gly Leu Met
565 570 575

Ala Ala Gly Glu Ala Glu His Glu Ala Thr Arg Arg Gly Ile Ala Tyr
580 585 590

Leu Gln Ala Thr Gln Lys Pro Asp Gly Glu Trp Asp Glu Ala Ala Tyr
595 600 605

Thr Ala Val Gly Phe Pro Arg Val Phe Tyr Leu Lys Tyr His Gly Tyr
610 615 620

Arg Gln Phe Phe Pro Leu Met Ala Leu Ser Arg Tyr Lys Asn Leu Arg
625 630 635 640

Ser Ser Asn Met Lys Lys Val Ser Phe Gly Phe
645 650


<210> 158
<211> 665
<212> PRT
<213> Hyphomicrobium denitrificans

<400> 158
Met Thr Thr Asn Ala Ala Ala Thr Ser Ala Arg Ser Gly Glu Asp Ala
1 5 10 15

Ile Arg Gln Val Ser Gly Gln Gln Leu Glu Thr Ala Ile Ala Ser Ala
20 25 30

Arg Asn Ser Leu Leu Ala Leu Gln Arg Pro Asp Gly His Phe Val Phe
35 40 45

Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val Leu Met Arg
50 55 60

His Tyr Leu Ala Glu Pro Val Asp Ala Val Leu Glu Glu Lys Ile Ala
65 70 75 80

Arg Tyr Leu Arg Arg Ile Gln Ser Asp Asp Gly Gly Trp Pro Leu Phe
85 90 95

Arg Asp Gly Ala Ser Asn Ile Ser Ala Ser Val Lys Ala Tyr Tyr Ala
100 105 110

Leu Lys Met Ile Gly Asp Ala Pro Asn Ala Pro His Met Gln Lys Ala
115 120 125

Arg Ala Trp Ile Leu Ala Gln Gly Gly Ala Ser His Ser Asn Val Phe
130 135 140

Thr Arg Asn Leu Leu Ala Leu Phe Gly Ala Ile Pro Trp Ser Gly Val
145 150 155 160

Pro Val Met Pro Val Glu Ile Met Leu Leu Pro Lys Trp Phe Pro Phe
165 170 175

His Ile Asp Lys Ile Ser Tyr Trp Ala Arg Thr Val Leu Ile Pro Leu
180 185 190

Thr Val Leu Asn Ala Leu Lys Pro Val Ala Arg Asn Pro Lys Gly Val
195 200 205

Gly Ile Ala Glu Leu Phe Val Thr Pro Pro Asp Gln Val Arg Asn Trp
210 215 220

Pro Lys Gly Pro His Gln Lys Phe Pro Trp Ser Gln Val Phe Gly Gly
225 230 235 240

Ile Asp Arg Val Leu Arg Leu Phe Glu Pro Ala Phe Pro Lys Ser Leu
245 250 255

Arg Lys Lys Ser Ile Asp Lys Ala Val Ala Phe Ala Thr Glu Arg Leu
260 265 270

Asn Gly Glu Asp Gly Leu Gly Gly Ile Phe Pro Ala Met Val Asn Ala
275 280 285

Leu Leu Val Tyr Asp Ala Leu Gly Tyr Pro His Asp His Pro Asp Tyr
290 295 300

Val Thr Ala Arg Gly Ser Ile Glu Lys Leu Leu Val Ile Lys Asp Asp
305 310 315 320

Glu Ala Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala Leu
325 330 335

Ala Val His Ala Leu Met Glu Ser Gly Val Ala Gln Ala Asp Gln Asn
340 345 350

Val Asp Arg Ala Leu Ala Trp Leu Lys Pro Leu Gln Val Leu Asp Thr
355 360 365

Val Gly Asp Trp Ala Ala Ser Arg Pro Gly Val Arg Pro Gly Gly Trp
370 375 380

Ala Phe Gln Tyr Ala Asn Ala Tyr Tyr Pro Asp Val Asp Asp Thr Ala
385 390 395 400

Val Val Val Met Ala Met Asp Arg Ala Ala Gly Gly Asp Ala Ala Lys
405 410 415

Arg Asp His Tyr Arg Glu Ser Met Ala Arg Gly Arg Glu Trp Val Ala
420 425 430

Gly Val Gln Ser Lys Asn Gly Gly Trp Gly Ala Phe Asp Ala Asp Asn
435 440 445

Thr Tyr Glu Tyr Leu Asn Gln Ile Pro Phe Ser Asp His Gly Ala Leu
450 455 460

Leu Asp Pro Pro Thr Ala Asp Val Ser Ala Arg Cys Val Ser Met Leu
465 470 475 480

Ala Gln Leu Gly Glu Arg Arg Glu Thr Ser Pro Val Leu Asp Lys Ala
485 490 495

Met Arg Tyr Leu Glu Ser Thr Gln Glu Lys Asp Gly Ser Trp Tyr Gly
500 505 510

Arg Trp Gly Met Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala
515 520 525

Leu Asn Ala Ala Gly Val Ala Pro Ser Ala Pro Ser Met Arg Lys Ala
530 535 540

Ala Asp Trp Leu Leu Ser Ile Gln Asn Ser Asp Gly Gly Trp Gly Glu
545 550 555 560

Asp Gly Glu Ser Tyr Ser Leu Asp Tyr Lys Gly Tyr Glu Pro Ala Pro
565 570 575

Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Met Ala Ala
580 585 590

Gly Glu Val Asp His Pro Ala Val Gln Arg Gly Val Ala Tyr Leu Ala
595 600 605

Ala Lys Gln Gly Ser Asp Gly Phe Trp Gly Glu Glu Arg Phe Thr Ala
610 615 620

Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Ser Lys
625 630 635 640

Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu Asn Ala Ala
645 650 655

Asn Ser Lys Ser Val Leu Val Gly Met
660 665


<210> 159
<211> 694
<212> PRT
<213> Leptospirillum ferrodiazotrophum

<400> 159
Met Ser Gly Gln Ser Asn Phe Thr Gly Gly Lys Lys Met Thr Pro Ala
1 5 10 15

Glu Gly Ser Ser Ser Pro Ala Pro Ala Leu Leu Glu Lys Ala Ala Pro
20 25 30

Ser Ile Glu Leu Asp Glu Arg Ser Asp Pro Leu Ser Arg Thr Leu Ala
35 40 45

Arg Ala Val Ser Trp Leu Val Ala Ala Gln Asp Gly Ala Gly His Trp
50 55 60

Val Ala Pro Leu Glu Ala Asp Ala Thr Ile Pro Ser Glu Tyr Val Phe
65 70 75 80

Leu His Glu Val Leu Gly Arg Pro Leu Asp Pro Val Arg Arg Asp Lys
85 90 95

Ile Val Arg Ala Ile Leu Ser Val Gln Gly Lys Glu Gly Ala Trp Pro
100 105 110

Leu Phe His Asp Gly Asp Pro Asp Ile Ser Ala Thr Val Lys Ala Tyr
115 120 125

Gln Ala Leu Lys Leu Cys Gly Phe Asp Pro Ser His Pro Ala Leu Val
130 135 140

Arg Ala Arg Glu Trp Val Leu Ser Gln Gly Gly Ala Gly Lys Val Asn
145 150 155 160

Val Phe Thr Arg Ile Ala Leu Ala Ile Phe Gly Gln Tyr Ser Trp Thr
165 170 175

Lys Ile Pro Ala Leu Pro Ala Glu Met Val Leu Leu Pro Ser Trp Phe
180 185 190

Pro Phe Ser Ile Tyr Ser Val Ser Tyr Trp Ser Arg Thr Val Ile Val
195 200 205

Pro Leu Leu Phe Ile Tyr His His Lys Pro Leu Val Arg Leu Ser Pro
210 215 220

Glu Arg Gly Ile Ser Glu Leu Phe Asp Pro Ala Arg Pro Asp Gly Glu
225 230 235 240

Ser Phe Ala Pro Ser Pro Asp Phe Phe Ser Leu Arg Asn Leu Phe Leu
245 250 255

Leu Leu Asp Lys Val Leu Gln Val Trp Asn Arg His Pro Pro Gly Phe
260 265 270

Leu Arg Lys Lys Ala Leu Ser Phe Ala Met Glu Trp Met Val Pro Arg
275 280 285

Leu Lys Gly Glu Gly Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Asn
290 295 300

Ser Ala Val Ala Leu Ser Leu Glu Gly Tyr Glu Leu Asp His Pro Leu
305 310 315 320

Met Gln Arg Val Leu Ala Ser Ile Asp Asp Leu Leu Ile Glu Gly Glu
325 330 335

Lys Glu Val Leu Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala
340 345 350

Leu Ala Met Gly Ala Leu Ile Glu Ala Gly Ile Ser Pro Asp Ser Pro
355 360 365

Thr Val Asp Arg Ala Met Glu Trp Phe Cys Ala Arg Glu Val Arg Thr
370 375 380

Arg Gly Asp Trp Ala Ile Arg Ala Pro Asp Cys Glu Pro Gly Gly Trp
385 390 395 400

Ala Phe Gln Phe Glu Asn Asp Tyr Tyr Pro Asp Val Asp Asp Thr Ala
405 410 415

Met Val Leu Met Gly Met Ala Lys Ile Leu Pro Ala Arg Pro Asp Leu
420 425 430

Ala Ala Arg Met Glu Gly Val Phe Arg Arg Ala Thr Leu Trp Val Met
435 440 445

Ala Met Gln Gly Thr Asp Gly Gly Trp Gly Ala Phe Asp Arg Asp Asn
450 455 460

Asp Leu Leu Phe Leu Asn His Ile Pro Phe Ala Asp His Gly Ala Leu
465 470 475 480

Leu Asp Pro Ser Thr Ala Asp Leu Thr Gly Arg Val Leu Glu Leu Leu
485 490 495

Gly Ala Leu Gly Tyr Gly Pro Asp Phe Pro Pro Ala Ala Arg Ala Ile
500 505 510

Arg Tyr Leu Arg Arg Glu Gln Glu Glu Asp Gly Ser Trp Phe Gly Arg
515 520 525

Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Val Ala Gly Leu
530 535 540

Lys Ser Ile Gly Val Pro Met Ser Glu Pro Trp Val Met Arg Ser Met
545 550 555 560

Glu Phe Leu Leu Ala Arg Gln Asn Pro Asp Gly Gly Trp Gly Glu Asp
565 570 575

Cys Leu Ser Tyr Ala Ser Arg Asp Phe Ala Gly Arg Gly Ala Ser Thr
580 585 590

Pro Ser Gln Thr Ala Trp Ala Leu Ile Ala Leu Leu His Gly Gly His
595 600 605

Ala Gly His Met Ala Val Arg Gln Gly Val Asp Tyr Leu Ile Gln Gln
610 615 620

Met Thr Pro Glu Gly Thr Trp Asn Glu Glu Leu Phe Thr Gly Thr Gly
625 630 635 640

Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Met Tyr Arg His Tyr Phe
645 650 655

Pro Leu Trp Ala Leu Ala Leu Tyr Arg Asn Met Thr Glu Arg Gly Arg
660 665 670

Ala Leu Gly His Glu Arg Val Asp Phe Trp Lys Thr Ala Pro Tyr Ala
675 680 685

Pro Ile Ala Arg Ser Val
690


<210> 160
<211> 683
<212> PRT
<213> Leptospirillum rubarum

<400> 160
Met Lys Gly Lys Glu Pro Thr Arg Glu Glu Leu Leu Ser Phe Ser Ser
1 5 10 15

Gly Ile Gln Met Asp Ser Ser Ala Glu Asn Thr Thr Pro Val Ser Thr
20 25 30

Glu Glu Leu Gln Glu Lys Val Arg Leu Ala Ala Glu Ser Leu Ile Ser
35 40 45

Arg Gln Val Glu Glu Gly Tyr Trp Val Glu Pro Leu Glu Ala Asp Val
50 55 60

Thr Ile Thr Ser Glu Tyr Ile Leu Leu Gln Tyr Leu Leu Gly Arg Glu
65 70 75 80

Arg Asp Glu Phe Phe Arg Arg Ala Ala Pro Phe Ile Leu Glu Ser Gln
85 90 95

Gly Glu Asp Gly Gly Trp Pro Leu Tyr His Gly Gly Pro Ala Glu Ile
100 105 110

Ser Ala Thr Val Lys Ala Tyr Leu Ala Leu Lys Leu Leu Gly Tyr Asp
115 120 125

Ala Asp His Pro Ala Met Gln Arg Ala Arg Ala Leu Val Leu Glu Arg
130 135 140

Gly Gly Ala Ile Asn Val Asn Val Phe Thr Arg Ile Thr Leu Ala Leu
145 150 155 160

Phe Gly Gln Tyr Asp Trp Lys Gly Val Pro Ala Leu Pro Pro Glu Met
165 170 175

Ile Leu Leu Pro Arg Trp Phe Pro Leu Ser Ile Tyr Thr Val Ser Tyr
180 185 190

Trp Ser Arg Thr Val Ile Val Pro Leu Leu Phe Ile Tyr His Tyr Lys
195 200 205

Pro Leu Leu Glu Leu Pro Pro Glu Lys Gly Val Gln Glu Leu Phe Ile
210 215 220

Thr Pro Met Ser Glu Val Arg Val His Tyr Ala Trp Asp Lys His Trp
225 230 235 240

Val Ser Trp Lys Asn Leu Phe Phe Val Leu Asp Arg Ile Leu Gln Ala
245 250 255

Trp Asn Arg His Pro Pro Ser Phe Leu Arg Arg Lys Ala Leu Lys Lys
260 265 270

Ala Met Glu Trp Met Ile Pro Arg Leu Lys Gly Glu Gly Gly Leu Gly
275 280 285

Ala Ile Tyr Pro Ala Met Ala Asn Ser Val Leu Ala Leu Arg Leu Glu
290 295 300

Gly Tyr Ala Met Asp His Pro Leu Val Arg Arg Ala Ile Gln Ser Ile
305 310 315 320

Asp Asp Leu Val Phe Asp Leu Gly Glu Gln Gln Ser Val Gln Pro Cys
325 330 335

His Ser Pro Ile Trp Asp Thr Ala Leu Ala Leu Gly Ala Leu Tyr Glu
340 345 350

Ala Gly Leu Asp Glu Gly Ser Pro Phe Val Ser Arg Ala Leu Asp Trp
355 360 365

Phe Cys Arg Lys Glu Val Arg Thr Val Gly Asp Trp Ser Val Arg Val
370 375 380

Pro Gly Val Glu Ala Gly Gly Trp Ala Phe Gln Phe Glu Asn Asp Tyr
385 390 395 400

Tyr Pro Asp Ile Asp Asp Thr Ser Val Val Leu Met Asp Phe Ala Lys
405 410 415

Trp Val Pro Glu Met Gly Ala Tyr Arg Asp Val Phe Arg Arg Ala Ile
420 425 430

Glu Trp Thr Leu Ser Met Gln Gly Thr Asp Gly Gly Trp Gly Ala Phe
435 440 445

Asp Lys Asp Asn Asp Phe Leu Phe Leu Asn Asn Ile Pro Phe Ala Asp
450 455 460

His Gly Ala Leu Leu Asp Pro Ser Thr Ser Asp Val Thr Gly Arg Val
465 470 475 480

Thr Glu Leu Leu Gly Ile Leu Gly Tyr Asp Ala Arg Thr Pro Val Val
485 490 495

Arg Arg Ala Leu Arg Phe Leu Arg Lys Glu Gln Glu Glu Asn Gly Ser
500 505 510

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
515 520 525

Val Ser Ala Leu Lys Ala Val Gly Glu Asp Met Ser Ala Pro Tyr Val
530 535 540

Gln Lys Ala Met Gln Phe Leu Phe Ser Arg Gln Asn Pro Asp Gly Gly
545 550 555 560

Trp Gly Glu Ser Cys Tyr Ser Tyr Phe Arg Lys Asp Thr Ala Gly Glu
565 570 575

Gly Val Ser Thr Ser Ser Gln Thr Ala Trp Ala Leu Ile Ala Leu Ile
580 585 590

His Gly Gly His Val Arg His Pro Ala Val Ser Lys Gly Ile Asp Phe
595 600 605

Leu Leu Ser Arg Gln Gln Ala Asp Gly Lys Trp Leu Glu Gln Glu Tyr
610 615 620

Thr Gly Thr Gly Phe Pro Lys Val Phe Tyr Leu Arg Tyr Asn Met Tyr
625 630 635 640

Arg Asp Tyr Phe Ser Leu Trp Ala Leu Ser Leu Tyr Arg Asn Val Leu
645 650 655

Leu Asp Gly Gln Ser Arg Val Glu Arg Leu Ala Arg Arg Trp Lys Gly
660 665 670

Asn Pro Tyr Pro Val Arg Ser Arg Phe Leu Ala
675 680


<210> 161
<211> 683
<212> PRT
<213> Leptospirillum sp.

<400> 161
Met Glu Gly Lys Asp Pro Thr Arg Glu Glu Leu Leu Ser Phe Thr Ser
1 5 10 15

Gly Ile Gln Met Asp Ser Arg Val Gly Asn Thr Asn Pro Val Ser Thr
20 25 30

Glu Glu Leu Gln Glu Lys Val Arg Leu Ala Ala Glu Ser Leu Ile Ser
35 40 45

Arg Gln Gly Glu Glu Gly Tyr Trp Val Glu Pro Leu Glu Ala Asp Ile
50 55 60

Thr Ile Thr Ser Glu Tyr Val Leu Leu Gln Tyr Leu Leu Gly Arg Glu
65 70 75 80

Arg Asp Glu Phe Phe Arg Arg Ala Ala Pro Phe Ile Leu Glu Ser Gln
85 90 95

Gly Glu Asp Gly Gly Trp Pro Leu Tyr Asn Gly Gly Pro Ala Glu Ile
100 105 110

Ser Ala Thr Val Lys Ala Tyr Leu Ala Leu Lys Leu Leu Gly Tyr Asp
115 120 125

Ala Asp His Pro Ala Met Gln Arg Ala Arg Ala Leu Val Leu Glu Arg
130 135 140

Gly Gly Ala Ile Asn Val Asn Val Phe Thr Arg Ile Thr Leu Ala Leu
145 150 155 160

Phe Gly Gln Tyr Asp Trp Lys Gly Val Pro Ala Leu Pro Pro Glu Met
165 170 175

Ile Leu Leu Pro Arg Trp Phe Pro Leu Ser Ile Tyr Thr Val Ser Tyr
180 185 190

Trp Ser Arg Thr Val Ile Val Pro Leu Leu Phe Ile Tyr His Tyr Lys
195 200 205

Pro Leu Leu Glu Leu Pro Pro Glu Lys Gly Val Gln Glu Leu Phe Ile
210 215 220

Thr Pro Met Ser Glu Val Arg Val His Tyr Ala Trp Asp Lys His Trp
225 230 235 240

Val Ser Trp Lys Asn Leu Phe Phe Val Leu Asp Arg Ile Leu Gln Ala
245 250 255

Trp Asn Arg His Pro Pro Ser Phe Leu Arg Arg Lys Ala Leu Lys Lys
260 265 270

Ala Met Glu Trp Met Ile Pro Arg Leu Lys Gly Glu Gly Gly Leu Gly
275 280 285

Ala Ile Tyr Pro Ala Met Ala Asn Ser Val Leu Ala Leu Arg Leu Glu
290 295 300

Gly Tyr Glu Met Asp His Pro Leu Val Arg Arg Ala Ile Gln Ser Ile
305 310 315 320

Asp Asp Leu Val Phe Asp Leu Gly Glu Gln Gln Ser Val Gln Pro Cys
325 330 335

His Ser Pro Ile Trp Asp Thr Ala Leu Ala Leu Gly Ala Leu Tyr Glu
340 345 350

Ala Gly Leu Asp Glu Gly Ser Pro Phe Val Ser Arg Ala Leu Asp Trp
355 360 365

Phe Cys Arg Lys Glu Val Arg Thr Val Gly Asp Trp Ser Val Arg Val
370 375 380

Pro Gly Val Glu Ala Gly Gly Trp Ala Phe Gln Phe Glu Asn Asp Tyr
385 390 395 400

Tyr Pro Asp Ile Asp Asp Thr Ser Val Val Leu Met Asp Phe Ala Lys
405 410 415

Trp Val Pro Glu Met Gly Ala Tyr Arg Asp Val Phe Arg Arg Ala Ile
420 425 430

Glu Trp Thr Leu Ser Met Gln Gly Thr Asp Gly Gly Trp Gly Ala Phe
435 440 445

Asp Lys Asp Asn Asp Phe Leu Phe Leu Asn Asn Ile Pro Phe Ala Asp
450 455 460

His Gly Ala Leu Leu Asp Pro Ser Thr Ser Asp Val Thr Gly Arg Val
465 470 475 480

Thr Glu Leu Leu Gly Ile Leu Gly Tyr Asp Ala Arg Thr Pro Val Val
485 490 495

Arg Arg Ala Leu Arg Phe Leu Arg Lys Glu Gln Glu Glu Asn Gly Ser
500 505 510

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
515 520 525

Val Ser Ala Leu Lys Ala Val Gly Glu Asp Met Ser Ala Pro Tyr Val
530 535 540

Gln Arg Ala Met Gln Phe Leu Phe Ser Arg Gln Asn Pro Asp Gly Gly
545 550 555 560

Trp Gly Glu Ser Cys Tyr Ser Tyr Phe Arg Lys Asp Thr Ala Gly Glu
565 570 575

Gly Val Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Ile Ala Leu Ile
580 585 590

His Gly Gly His Val Arg His Pro Ala Val Ser Lys Gly Ile Asp Phe
595 600 605

Leu Leu Ser Arg Gln Gln Ala Asp Gly Lys Trp Leu Glu Gln Glu Tyr
610 615 620

Thr Gly Thr Gly Phe Pro Lys Val Phe Tyr Leu Arg Tyr Asn Met Tyr
625 630 635 640

Arg Asp Tyr Phe Ser Leu Trp Ala Leu Ser Leu Tyr Arg Asn Val Leu
645 650 655

Leu Asp Gly Gln Ser Arg Val Glu Arg Leu Ser Arg Arg Trp Lys Gly
660 665 670

Thr Pro Tyr Pro Val Arg Ser Arg Phe Leu Ala
675 680


<210> 162
<211> 683
<212> PRT
<213> Magnaporthe grisea

<400> 162
Met Ser Pro Phe Leu Gln Ala Ser Asp Asp Asn Asn Pro Leu Phe Lys
1 5 10 15

Glu Ser Cys Gln Ala Leu Asp His Ala Thr Glu Phe Ala Arg Asp Thr
20 25 30

Leu Val Asn Lys Glu His Trp Cys Gly Trp Val Leu Ser Asn Val Thr
35 40 45

Val Thr Ala Glu Trp Ile Phe Leu Gln Tyr Ile Leu Gly Leu Glu Met
50 55 60

Ser Asn Glu Asp Arg Arg Gly Phe Leu Lys His Phe Thr Ser Ser Gln
65 70 75 80

Arg Pro Asp Gly Ser Trp Ser Leu Ala Thr Gln Thr Thr Thr Gly Gly
85 90 95

Glu Leu Ser Cys Thr Ile Glu Ala Tyr Leu Ala Leu Lys Ile Leu Gly
100 105 110

Val Ser Pro Glu Glu Asp Tyr Met Val Arg Ala Arg Asp Tyr Val Arg
115 120 125

Ser His Gly Gly Ala Glu Lys Met Arg Met Leu Ser Arg Phe His Leu
130 135 140

Ala Met Phe Gly Leu Ile Pro Trp Ala Ala Val Pro Gln Met Pro Pro
145 150 155 160

Glu Leu Ile Phe Met Pro Ser Trp Ser Leu Val Asn Ile Tyr Lys Phe
165 170 175

Ser Ser Trp Ala Arg Cys Asn Ile Val Gly Leu Cys Met Leu Arg Val
180 185 190

His Glu Pro Leu Tyr Ala Leu Pro Asn Gly Lys Gln Leu Asp Asn Asp
195 200 205

Tyr Leu Asp Glu Leu Trp Leu Asp Pro Tyr His Lys Ala Ile Pro Tyr
210 215 220

Thr Val Pro Tyr Leu Gln Leu Met Gln Thr Ser Pro Leu Gly Val Leu
225 230 235 240

Phe Gln Leu Gly Asp Leu Phe Leu Trp Leu Leu Ser Phe Leu Gly Phe
245 250 255

Trp Phe Leu Arg Arg Trp Ala Val Ser Ser Ser Ile Gln Trp Thr Leu
260 265 270

Asp His Gln Glu Pro Ser Gly Asp Trp Gly Gly Ile Tyr Pro Pro Met
275 280 285

His His Asn Ile Leu Ala Leu Met Leu Glu Gly Trp Ser Gln Asp Asp
290 295 300

Pro Val Ile Gln Arg Gly Ile Gly Ala Cys Gln Arg Phe Leu Ala Glu
305 310 315 320

Asp Pro Ala His Gly Lys Trp Met Gln Pro Ser Val Ser Pro Val Trp
325 330 335

Asp Thr Phe Leu Met Ile Arg Ala Val Ala Asp Ala Lys Thr Thr Asp
340 345 350

Asp Ala Asp Lys Leu Leu Val Lys Pro Val Asp Trp Val Leu Ala Gln
355 360 365

Gln Ile Asp Asp Asp His Ile Gly Asp Trp Arg Ile Tyr Arg Pro Asp
370 375 380

Ile Pro Ala Gly Gly Phe Ala Phe Glu Tyr Phe Asn Lys Trp Tyr Pro
385 390 395 400

Asp Val Asp Asp Thr Ala Val Gly Val Val Ala Leu Met Arg His Asp
405 410 415

Pro Ser Leu Val Asn Asp Asp Arg Ile Leu Lys Ala Ala Ala Trp Thr
420 425 430

Leu Gly Met Gln Asn Arg Asp Phe Gly Trp Ala Ala Phe Asp Ala Asp
435 440 445

Asn Asn Ala Phe Tyr Leu His Ala Thr Pro Phe Ser Asp Met Asp Ser
450 455 460

Leu Thr Asp Ser Ser Thr Pro Asp Val Thr Gly His Val Leu Glu Met
465 470 475 480

Leu Gly Leu Met Tyr Arg Leu Glu Arg Gln Gly Arg Val Lys Ser Pro
485 490 495

Glu Met Leu Ala Phe Leu Ser Gln Ser His Gly Ala Cys Asp Arg Gly
500 505 510

Leu Gly Tyr Leu Leu Gly Ser Gln Glu Ala Phe Gly Gly Trp Tyr Gly
515 520 525

Arg Trp Gly Val Asn Tyr Ile Phe Gly Thr Ser Ala Ala Leu Cys Ala
530 535 540

Leu Ala Tyr Phe Ala Asp Arg Lys Gly Val Arg Gly Lys Met Ala Ala
545 550 555 560

Gly Ala Asp Trp Leu Arg Ser Arg Gln Asn Pro Asp Gly Gly Trp Gly
565 570 575

Glu Leu Leu Glu Ser Tyr Asp Asn Lys Ala Leu Ala Gly Arg Gly Arg
580 585 590

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Gln Gly Leu Leu Glu Leu
595 600 605

Glu Asp Pro Arg Gly Glu Val Val Glu Ala Gly Val Asn Trp Leu Leu
610 615 620

Arg His Gln Val Thr Ser Pro Ser Arg Asn Ser Gly Arg Val Ser Ala
625 630 635 640

Thr Trp Pro Glu Asp Asp Tyr Thr Ala Thr Gly Phe Pro Gly His Phe
645 650 655

Tyr Leu Lys Tyr Glu Leu Tyr Cys His Tyr Phe Pro Met Met Ala Leu
660 665 670

Ala Arg Tyr Arg Ser Cys Ile Gln Asp Gly Ala
675 680


<210> 163
<211> 667
<212> PRT
<213> Magnetospirillum magnetotacticum

<400> 163
Met Arg Glu Ala Ala Val Ser Lys Val Glu Thr Leu Gln Arg Pro Lys
1 5 10 15

Thr Arg Asp Val Ser Leu Asp Asp Val Glu Arg Gly Val Gln Ser Ala
20 25 30

Ala Arg Ala Leu Thr Asp Met Thr Gln Ala Asp Gly His Ile Cys Phe
35 40 45

Glu Leu Glu Ala Asp Ala Thr Ile Pro Ser Glu Tyr Ile Leu Phe His
50 55 60

His Phe Arg Gly Thr Glu Pro Arg Ala Gly Leu Glu Ala Lys Ile Gly
65 70 75 80

Asn Tyr Leu Arg Arg Thr Gln Ser Lys Val His Gly Gly Trp Ala Leu
85 90 95

Val His Asp Gly Pro Phe Asp Met Ser Ala Ser Val Lys Ala Tyr Phe
100 105 110

Ala Leu Lys Met Ile Gly Asp Asp Ile Glu Ala Pro His Met Arg Ala
115 120 125

Val Arg Lys Ala Ile Leu Gln Arg Gly Gly Ala Ala Asn Ala Asn Val
130 135 140

Phe Thr Arg Ile Leu Leu Ala Leu Tyr Gly Glu Val Pro Trp Thr Ala
145 150 155 160

Val Pro Val Met Pro Val Glu Val Met His Leu Pro Lys Trp Phe Pro
165 170 175

Phe His Leu Asp Lys Val Ser Tyr Trp Ala Arg Cys Thr Met Val Pro
180 185 190

Leu Phe Val Ile Gln Ala Lys Lys Pro Arg Ala Lys Asn Pro Arg Gly
195 200 205

Val Gly Val Ala Glu Leu Phe Val Thr Pro Pro Asp Ser Val Arg Thr
210 215 220

Trp Pro Gly Ser Pro His Ala Thr Trp Pro Trp Thr Pro Ile Phe Gly
225 230 235 240

Ala Ile Asp Arg Val Leu Gln Lys Thr Gln Asp His Phe Pro Lys Val
245 250 255

Pro Arg Gln Arg Ala Ile Asp Lys Ala Val Ala Trp Val Ser Glu Arg
260 265 270

Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ser Met Val Asn
275 280 285

Ser Val Leu Met Tyr Glu Val Leu Gly Tyr Pro Pro Asp His Pro Gln
290 295 300

Val Lys Ile Ala Leu Glu Ala Ile Glu Lys Leu Val Ala Glu Lys Asp
305 310 315 320

Asp Glu Ala Tyr Val Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala
325 330 335

Leu Thr Ser His Ala Met Leu Glu Val Gly Gly Thr Gln Ala Glu Ala
340 345 350

Asn Ala Arg Ala Gly Leu Asp Trp Leu Lys Pro Leu Gln Ile Leu Asp
355 360 365

Ile Lys Gly Asp Trp Ala Glu Thr Lys Pro Asn Val Arg Pro Gly Gly
370 375 380

Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr
385 390 395 400

Ala Val Val Val Met Ala Met Asp Arg Ala Gln Arg Gln His Gly Leu
405 410 415

Val Ser Gly Met Pro Asp Tyr Ser Thr Ser Ile Ala Arg Ala Arg Glu
420 425 430

Trp Val Glu Gly Leu Gln Ser Ala Asp Gly Gly Trp Ala Ala Phe Asp
435 440 445

Ala Asp Asn Asn His His Tyr Leu Asn His Ile Pro Phe Ser Asp His
450 455 460

Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Val Val
465 470 475 480

Ser Met Leu Ala Gln Leu Gly Glu Thr Arg Glu Thr Ser Arg Ala Leu
485 490 495

Asp Arg Gly Val Thr Tyr Leu Leu Asn Asp Gln Glu Lys Asp Gly Ser
500 505 510

Trp Tyr Gly Arg Trp Gly Met Asn Phe Ile Tyr Gly Thr Trp Ser Val
515 520 525

Leu Cys Ala Leu Asn Ala Ala Gly Val Asp Pro Gln Ser Pro Glu Ile
530 535 540

Arg Lys Ala Val Ala Trp Leu Ile Arg Ile Gln Asn Pro Asp Gly Gly
545 550 555 560

Trp Gly Glu Asp Ala Ser Ser Tyr Lys Leu Asn Pro Glu Phe Glu Pro
565 570 575

Gly Tyr Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Met
580 585 590

Ala Val Gly Glu Val Asp Asp Pro Ala Val Ala Arg Gly Val Asn Tyr
595 600 605

Leu Met Arg Thr Gln Gly Ala Asp Gly Leu Trp Asn Glu Glu Arg Tyr
610 615 620

Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr
625 630 635 640

Pro Lys Phe Phe Pro Leu Trp Ala Met Ala Arg Phe Arg Asn Leu Lys
645 650 655

Arg Gly Asn Ser Arg Gln Val Gln Phe Gly Met
660 665


<210> 164
<211> 691
<212> PRT
<213> Methylacidiphilum infernorum

<400> 164
Met His Ser Gly Arg Val Phe Leu Glu Lys Glu Asn Arg Glu Glu Asn
1 5 10 15

Arg Ala Thr Phe His Ser Ser Pro Leu Ile Leu Val Glu Glu Ser Leu
20 25 30

Asn Leu Pro Lys Lys Val Glu Glu Thr Ile Lys Lys Ala Gln Arg Tyr
35 40 45

Leu Leu Ser Ile Gln Lys Glu Asp Gly His Trp Val Gly Glu Leu Phe
50 55 60

Val Asp Val Thr Leu Ala Cys Asp Cys Ile His Leu Met His Trp Arg
65 70 75 80

Gly Lys Ile Asp Tyr Lys Lys Gln Leu Arg Leu Val Lys His Ile Val
85 90 95

Asp Arg Gln Leu Pro Asp Gly Gly Trp Asn Ile Tyr Pro Gly Gly Pro
100 105 110

Ser Glu Val Asn Ala Thr Val Lys Ala Tyr Phe Ala Leu Lys Leu Ala
115 120 125

Gly Phe Ser Pro Asp Asp Pro Leu Met Ala Lys Ala Arg Ser Thr Ile
130 135 140

Leu Arg Leu Gly Gly Ile Pro Lys Cys Met Thr Tyr Thr Lys Leu Gly
145 150 155 160

Leu Ala Leu Leu Gly Val Tyr Pro Trp Asp Arg Leu Pro Val Ile Pro
165 170 175

Pro Glu Ile Ile Leu Phe Pro Asn Trp Phe Pro Phe Asn Ile Tyr Glu
180 185 190

Ile Ser Ala Trp Ser Arg Ala Met Leu Val Pro Leu Ser Val Ile His
195 200 205

His Phe Lys Pro Thr Arg Asn Leu Pro Glu Lys Tyr Gln Leu His Glu
210 215 220

Leu Phe Pro Tyr Gly Thr Glu His Gly Lys Phe Ser Trp Leu Lys Lys
225 230 235 240

Gly Ala Arg Tyr Leu Ser Lys Gln Gly Leu Phe Leu Ala Cys Asp Lys
245 250 255

Phe Leu Gln Tyr Trp Asp Lys Thr Ser Leu Lys Pro Phe Arg Lys Met
260 265 270

Ala Leu Lys Lys Ala Glu Lys Trp Leu Leu Glu Arg Ile Ser Ala Gly
275 280 285

Ser Asp Gly Leu Gly Ala Ile Phe Pro Ala Met His Tyr Ala Ile Met
290 295 300

Ala Leu Ile Ala Met Gly Tyr Thr Glu Asp Asn Pro Ile Leu Lys Lys
305 310 315 320

Ala Ile Ala Asp Phe Glu Gly Leu Glu Val Asp Asp Lys Lys Asn Asp
325 330 335

Asp Leu Arg Ile Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala Val
340 345 350

Gly Leu Val Ala Leu Ala Glu Ser Gly Val Ala Arg Asn Ala Lys Glu
355 360 365

Leu Lys Arg Ala Ala Tyr Trp Leu Leu Asp Arg Glu Ile Lys Ile Lys
370 375 380

Gly Asp Trp His Val Arg Asn Pro His Pro Glu Pro Ser Gly Trp Ala
385 390 395 400

Phe Glu Tyr Asn Asn Val Tyr Tyr Pro Asp Val Asp Asp Thr Leu Met
405 410 415

Val Leu Leu Ala Leu Arg Leu Ile Asp Ile Glu Asp Lys Ile Arg Lys
420 425 430

Glu Glu Val Met Gln Arg Ala Leu Arg Trp Val Ile Ser Phe Gln Cys
435 440 445

Lys Asn Gly Gly Trp Ala Ala Phe Asp Lys Asp Val Tyr Lys Lys Trp
450 455 460

Leu Glu Asp Ile Pro Phe Ala Asp His Asn Ala Ile Leu Asp Pro Pro
465 470 475 480

Cys Ser Asp Ile Thr Ala Arg Ala Leu Glu Leu Phe Gly Lys Met Gly
485 490 495

Ile Lys Lys Thr Glu Arg Phe Val Gln Lys Ala Ile Ala Tyr Leu Lys
500 505 510

Glu Thr Gln Glu Asn Asp Gly Ser Trp Met Gly Arg Trp Gly Val Asn
515 520 525

Tyr Ile Tyr Gly Thr Trp Gln Ala Leu Arg Gly Leu Gln Ala Ile Gly
530 535 540

Glu Asn Met Asn Gln Glu Trp Ile Leu Arg Ala Arg Asp Trp Leu Glu
545 550 555 560

Ser Cys Gln Asn Glu Asp Gly Gly Trp Gly Glu Thr Pro Ala Ser Tyr
565 570 575

Asp Asn Pro Gln Leu Lys Gly Lys Gly Pro Ser Thr Ala Ser Gln Thr
580 585 590

Ala Trp Ala Val Ser Gly Ile Met Ala Cys Gly Asp Ile Phe Arg Pro
595 600 605

Ser Val Ser Arg Gly Ile Lys Tyr Leu Cys Asp Arg Gln Leu Ser Asp
610 615 620

Gly Ser Trp Ala Glu Glu Phe Leu Thr Gly Thr Gly Phe Pro Gly Val
625 630 635 640

Phe Tyr Leu Lys Tyr Asp Met Tyr Arg Asn Ala Trp Pro Leu Leu Val
645 650 655

Ile Gly Glu Tyr His Arg Gln Tyr Leu Lys Ala Lys Glu Gln Val Ser
660 665 670

Tyr Trp Val Asp Gly Thr Ile Gly Arg Lys Val Lys Lys Glu Arg Leu
675 680 685

Pro Glu Ile
690


<210> 165
<211> 667
<212> PRT
<213> Methylobacterium chloromethanicum

<400> 165
Met Arg Glu Ala Ala Val Ser Lys Val Glu Thr Leu Gln Arg Pro Lys
1 5 10 15

Thr Arg Asp Val Ser Leu Asp Asp Val Glu Arg Gly Val Gln Ser Ala
20 25 30

Thr Arg Ala Leu Thr Glu Met Thr Gln Ala Asp Gly His Ile Cys Phe
35 40 45

Glu Leu Glu Ala Asp Ala Thr Ile Pro Ser Glu Tyr Ile Leu Phe His
50 55 60

Gln Phe Arg Gly Thr Glu Pro Arg Pro Gly Leu Glu Ala Lys Ile Gly
65 70 75 80

Asn Tyr Leu Arg Arg Thr Gln Ser Lys Val His Gly Gly Trp Ala Leu
85 90 95

Val His Asp Gly Pro Phe Asp Met Ser Ala Ser Val Lys Ala Tyr Phe
100 105 110

Ala Leu Lys Met Ile Gly Asp Asp Ile Glu Ala Pro His Met Arg Ala
115 120 125

Val Arg Lys Ala Ile Leu Gln Arg Gly Gly Ala Ala Asn Ala Asn Val
130 135 140

Phe Thr Arg Ile Leu Leu Ala Leu Tyr Gly Glu Val Pro Trp Ala Ala
145 150 155 160

Val Pro Val Met Pro Val Glu Val Met His Leu Pro Lys Trp Phe Pro
165 170 175

Phe His Leu Asp Lys Val Ser Tyr Trp Ala Arg Cys Thr Met Val Pro
180 185 190

Leu Phe Val Ile Gln Ala Lys Lys Pro Arg Ala Lys Asn Pro Arg Gly
195 200 205

Val Gly Val Ala Glu Leu Phe Val Thr Pro Pro Asp Ser Val Arg Thr
210 215 220

Trp Pro Gly Ser Pro His Ala Thr Trp Pro Trp Thr Pro Ile Phe Gly
225 230 235 240

Gly Ile Asp Arg Val Leu Gln Lys Thr Gln Asp His Phe Pro Lys Val
245 250 255

Pro Arg Gln Arg Ala Ile Asp Lys Ala Val Ala Trp Val Ser Glu Arg
260 265 270

Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn
275 280 285

Ser Val Leu Met Tyr Glu Val Leu Gly Tyr Pro Pro Glu His Pro Gln
290 295 300

Val Lys Ile Ala Leu Glu Ala Ile Glu Lys Leu Val Ala Glu Lys Glu
305 310 315 320

Asp Glu Ala Tyr Val Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala
325 330 335

Leu Asn Ser His Ala Met Leu Glu Ala Gly Gly His Gln Ala Glu Ala
340 345 350

Asn Ala Arg Ala Gly Leu Asp Trp Leu Lys Pro Leu Gln Ile Leu Asp
355 360 365

Ile Lys Gly Asp Trp Ala Glu Thr Lys Pro Asn Val Arg Pro Gly Gly
370 375 380

Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr
385 390 395 400

Ala Val Val Val Met Ala Met Asp Arg Ala Gln Arg Gln His Gly Leu
405 410 415

Val Ser Gly Met Pro Asp Tyr Ser Glu Ser Ile Ala Arg Ala Arg Glu
420 425 430

Trp Val Glu Gly Leu Gln Ser Ala Asp Gly Gly Trp Ala Ala Phe Asp
435 440 445

Ala Asp Asn Asn His His Tyr Leu Asn His Ile Pro Phe Ser Asp His
450 455 460

Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Val Val
465 470 475 480

Ser Met Leu Ser Gln Leu Gly Glu Thr Arg Ala Thr Ser Arg Ala Leu
485 490 495

Asp Arg Gly Val Thr Tyr Leu Leu Asn Asp Gln Glu Lys Asp Gly Ser
500 505 510

Trp Tyr Gly Arg Trp Gly Met Asn Phe Ile Tyr Gly Thr Trp Ser Val
515 520 525

Leu Cys Ala Leu Asn Thr Ala Gly Val Asp Pro Gln Ser Pro Glu Ile
530 535 540

Arg Lys Ala Val Ala Trp Leu Ile Arg Ile Gln Asn Pro Asp Gly Gly
545 550 555 560

Trp Gly Glu Asp Ala Ser Ser Tyr Lys Leu Asn Pro Glu Phe Glu Pro
565 570 575

Gly Tyr Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Met
580 585 590

Ala Ala Gly Glu Val Asp Asp Pro Ala Val Ala Arg Gly Val Asn Tyr
595 600 605

Leu Val Arg Thr Gln Gly Gln Asp Gly Leu Trp Ser Glu Glu Arg Tyr
610 615 620

Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr
625 630 635 640

Pro Lys Phe Phe Pro Leu Trp Ala Met Ala Arg Phe Arg Asn Leu Lys
645 650 655

Arg Gly Asn Ser Arg Gln Val Gln Phe Gly Met
660 665


<210> 166
<211> 645
<212> PRT
<213> Methylobacterium chloromethanicum

<400> 166
Met Asn Thr Glu Pro Arg Phe Ser Ala Pro Glu Thr Leu Arg Ala Ile
1 5 10 15

Ala Gly Ala Gly Arg Ala Leu Gly Arg His Gln Arg Arg Asp Gly His
20 25 30

Trp Val Phe Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val
35 40 45

Leu Leu Glu His Tyr Met Asp Arg Ile Thr Pro Glu Arg Gln Ala Arg
50 55 60

Ile Gly Ala Tyr Leu Arg Arg Ile Gln Gly Glu His Gly Gly Trp Pro
65 70 75 80

Met Phe His Ala Gly Glu Phe Asn Ile Ser Ala Ser Val Lys Ala Tyr
85 90 95

Cys Ala Leu Lys Ala Ile Gly Asp Asp Pro Gln Ala Pro His Met Val
100 105 110

Arg Ala Arg Gln Ala Ile Leu Gly His Gly Gly Ala Glu Arg Ala Asn
115 120 125

Val Phe Thr Arg Ile Gln Leu Ala Leu Phe Gly Ala Ile Pro Trp Arg
130 135 140

Gly Val Pro Val Met Pro Val Glu Ile Met His Leu Pro Lys Trp Phe
145 150 155 160

Phe Phe Asn Ile Trp Ala Met Ser Tyr Trp Ala Arg Thr Cys Val Val
165 170 175

Pro Leu Leu Val Leu Gln Ala Arg Lys Pro Arg Ala Arg Asn Pro Arg
180 185 190

Gln Val Ser Phe Asp Glu Ile Phe Arg Thr Glu Pro Asp Glu Val Arg
195 200 205

Asp Trp Ile Arg Gly Pro Tyr Arg Ser Arg Trp Gly Val Val Phe Lys
210 215 220

His Ile Asp Thr Val Leu Arg Trp Thr Glu Pro Leu Phe Ser Lys Val
225 230 235 240

Ala Arg Glu Ser Ala Ile Phe Lys Ala Val Asp Phe Val Glu Glu Arg
245 250 255

Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Tyr
260 265 270

Ala Leu Met Met Tyr Asp Val Leu Gly Tyr Pro Glu Asp Asp Pro Arg
275 280 285

Cys Val Thr Ile Trp Lys Ala Ile Asp Lys Leu Leu Ile Glu Thr Asp
290 295 300

Glu Glu Val Tyr Cys Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ser
305 310 315 320

Leu Ser Gly His Ala Met Ile Glu Ala Ala Arg Thr Gly Gly Ile Glu
325 330 335

Ala Gln Ala Glu Leu Asp Ala Ala Cys Asp Trp Leu Val Ala Arg Gln
340 345 350

Val Lys Asp Val Arg Gly Asp Trp Ala Glu Thr Arg Pro Asp Ala Glu
355 360 365

Pro Gly Gly Trp Ala Phe Gln Tyr Arg Asn Asp His Tyr Pro Asp Val
370 375 380

Asp Asp Thr Ala Val Val Ala Met Leu Leu His Arg Asn Gly Arg Pro
385 390 395 400

Glu His Ala Glu Ala Ile Glu Lys Ala Arg Arg Trp Val Val Gly Val
405 410 415

Gln Ser Arg Asn Gly Gly Trp Gly Ala Phe Asp Ala Asp Asn Asp Arg
420 425 430

Glu Phe Leu Asn His Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp
435 440 445

Pro Pro Thr Ala Asp Val Thr Gly Arg Cys Ile Ser Phe Leu Ser Gln
450 455 460

Leu Gly His Glu Glu Asp Arg Pro Val Ile Glu Arg Ala Leu Ala Tyr
465 470 475 480

Leu Arg Ala Glu Gln Glu Arg Asp Gly Ser Trp Tyr Gly Arg Trp Gly
485 490 495

Thr Asn Tyr Val Tyr Gly Thr Trp Thr Val Leu Cys Gly Leu Asn Ala
500 505 510

Ala Gly Ile Pro His Asp Asp Pro Met Val Arg Arg Ala Val Asp Trp
515 520 525

Leu Val Ser Ile Gln Arg Ala Asp Gly Gly Trp Gly Glu Asp Glu Arg
530 535 540

Ser Tyr Asp Val Gly His Tyr Val Glu Asn Ala Glu Ser Leu Pro Ser
545 550 555 560

Gln Thr Ala Trp Ala Met Leu Gly Leu Met Ser Val Gly Gln Ala Asp
565 570 575

His Pro Ala Val Leu Arg Gly Ala Ala Tyr Leu Gln Arg Thr Gln Gly
580 585 590

Pro Asp Gly Glu Trp Gln Glu Arg Ala Tyr Asn Ala Val Gly Phe Pro
595 600 605

Arg Val Phe Tyr Leu Lys Tyr His Gly Tyr Arg Leu Phe Phe Pro Leu
610 615 620

Phe Ala Leu Ser Arg Leu His Asn Leu Gln Arg Gly Asn Ser Arg Glu
625 630 635 640

Val Ser Phe Gly Phe
645


<210> 167
<211> 667
<212> PRT
<213> Methylobacterium extorquens

<400> 167
Met Arg Glu Ala Ala Val Ser Lys Val Glu Thr Leu Gln Arg Pro Lys
1 5 10 15

Thr Arg Asp Val Ser Leu Asp Asp Val Glu Arg Gly Val Gln Ser Ala
20 25 30

Thr Arg Ala Leu Thr Glu Met Thr Gln Ala Asp Gly His Ile Cys Phe
35 40 45

Glu Leu Glu Ala Asp Ala Thr Ile Pro Ser Glu Tyr Ile Leu Phe His
50 55 60

Gln Phe Arg Gly Thr Glu Pro Arg Pro Gly Leu Glu Ala Lys Ile Gly
65 70 75 80

Asn Tyr Leu Arg Arg Thr Gln Ser Lys Val His Gly Gly Trp Ala Leu
85 90 95

Val His Asp Gly Pro Phe Asp Met Ser Ala Ser Val Lys Ala Tyr Phe
100 105 110

Ala Leu Lys Met Ile Gly Asp Asp Ile Glu Ala Pro His Met Arg Ala
115 120 125

Val Arg Lys Ala Ile Leu Gln Arg Gly Gly Ala Ala Asn Ala Asn Val
130 135 140

Phe Thr Arg Ile Leu Leu Ala Leu Tyr Gly Glu Val Pro Trp Val Ala
145 150 155 160

Val Pro Val Met Pro Val Glu Val Met His Leu Pro Lys Trp Phe Pro
165 170 175

Phe His Leu Asp Lys Val Ser Tyr Trp Ala Arg Cys Thr Met Val Pro
180 185 190

Leu Phe Val Ile Gln Ala Lys Lys Pro Arg Ala Lys Asn Pro Arg Gly
195 200 205

Val Gly Val Ala Glu Leu Phe Val Thr Pro Pro Asp Ser Val Arg Thr
210 215 220

Trp Pro Gly Ser Pro His Ala Thr Trp Pro Trp Thr Pro Ile Phe Gly
225 230 235 240

Gly Ile Asp Arg Val Leu Gln Lys Thr Gln Asp His Phe Pro Lys Val
245 250 255

Pro Arg Gln Arg Ala Ile Asp Lys Ala Val Ala Trp Val Ser Glu Arg
260 265 270

Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn
275 280 285

Ser Val Leu Met Tyr Glu Val Leu Gly Tyr Pro Pro Glu His Pro Gln
290 295 300

Val Lys Ile Ala Leu Glu Ala Ile Glu Lys Leu Val Ala Glu Lys Glu
305 310 315 320

Asp Glu Ala Tyr Val Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala
325 330 335

Leu Asn Ser His Ala Met Leu Glu Ala Gly Gly His Gln Ala Glu Ala
340 345 350

Asn Ala Arg Ala Gly Leu Asp Trp Leu Lys Pro Leu Gln Ile Leu Asp
355 360 365

Ile Lys Gly Asp Trp Ala Glu Thr Lys Pro Asn Val Arg Pro Gly Gly
370 375 380

Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr
385 390 395 400

Ala Val Val Val Met Ala Met Asp Arg Ala Gln Arg Gln His Gly Leu
405 410 415

Val Ser Gly Met Pro Asp Tyr Ser Glu Ser Ile Ala Arg Ala Arg Glu
420 425 430

Trp Val Glu Gly Leu Gln Ser Ala Asp Gly Gly Trp Ala Ala Phe Asp
435 440 445

Ala Asp Asn Asn His His Tyr Leu Asn His Ile Pro Phe Ser Asp His
450 455 460

Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Val Val
465 470 475 480

Ser Met Leu Ser Gln Leu Gly Glu Thr Arg Ala Thr Ser Arg Ala Leu
485 490 495

Asp Arg Gly Val Thr Tyr Leu Leu Asn Asp Gln Glu Lys Asp Gly Ser
500 505 510

Trp Tyr Gly Arg Trp Gly Met Asn Phe Ile Tyr Gly Thr Trp Ser Val
515 520 525

Leu Cys Ala Leu Asn Ala Ala Gly Val Asp Pro Gln Ser Pro Glu Ile
530 535 540

Arg Lys Ala Val Ala Trp Leu Ile Arg Ile Gln Asn Pro Asp Gly Gly
545 550 555 560

Trp Gly Glu Asp Ala Ser Ser Tyr Lys Leu Asn Pro Glu Phe Glu Pro
565 570 575

Gly Tyr Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Met
580 585 590

Ala Ala Gly Glu Val Asp Asp Pro Ala Val Ala Arg Gly Val Asn Tyr
595 600 605

Leu Val Arg Thr Gln Gly Gln Asp Gly Leu Trp Ser Glu Glu Arg Tyr
610 615 620

Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr
625 630 635 640

Pro Lys Phe Phe Pro Leu Trp Ala Met Ala Arg Phe Arg Asn Leu Lys
645 650 655

Arg Gly Asn Ser Arg Gln Val Gln Phe Gly Met
660 665


<210> 168
<211> 663
<212> PRT
<213> Methylobacterium nodulans

<400> 168
Met Gly Lys Val Glu Thr Leu His Arg Met Ser Thr Gln Asp Ile Thr
1 5 10 15

Leu Asp Asp Val Glu Arg Arg Val Ser Leu Ala Ser Lys Ala Leu Met
20 25 30

Arg Leu Ala Gly Pro Asp Gly His Trp Cys Phe Glu Leu Glu Ala Asp
35 40 45

Ala Thr Ile Pro Ser Glu Tyr Ile Leu Tyr His His Phe Arg Gly Ser
50 55 60

Ile Pro Ser Ala Glu Leu Glu Gly Lys Ile Ala Asn Tyr Leu Arg Arg
65 70 75 80

Thr Gln Ser Ala Gln His Asp Gly Trp Ser Leu Val His Asp Gly Pro
85 90 95

Phe Asp Met Ser Ala Thr Val Lys Ala Tyr Phe Ala Leu Lys Met Ile
100 105 110

Gly Asp Ser Ile Glu Ala Pro His Met Arg Arg Ala Arg Glu Ala Ile
115 120 125

Leu Arg Arg Gly Gly Ala Ala His Ala Asn Val Phe Thr Arg Thr Leu
130 135 140

Leu Ala Leu Tyr Gly Glu Val Pro Trp Ser Ala Val Pro Val Met Pro
145 150 155 160

Val Glu Val Met Leu Leu Pro Arg Trp Phe Pro Phe His Leu Asp Lys
165 170 175

Val Ser Tyr Trp Ala Arg Thr Val Met Val Pro Leu Phe Val Leu Gln
180 185 190

Ala Lys Lys Pro Arg Ala Arg Asn Pro Arg Gly Ile Gly Ile Gln Glu
195 200 205

Leu Phe Val Glu Pro Pro Glu Arg Val Lys Arg Trp Pro Ala Gly Pro
210 215 220

Gln Glu Ser Ser Pro Trp Arg Pro Val Phe Ala Ala Ile Asp Lys Val
225 230 235 240

Leu Gln Lys Val Glu Gly Ser Phe Pro Ala Gly Ser Arg Ala Arg Ala
245 250 255

Ile Asp Lys Ala Val Ala Phe Val Ser Glu Arg Leu Asn Gly Glu Asp
260 265 270

Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn Ala Val Leu Met Tyr
275 280 285

Glu Ala Leu Gly Tyr Pro Glu Asp His Pro Leu Val Ala Thr Ala Arg
290 295 300

Ser Ser Val Glu Lys Leu Val Thr Val Lys Glu His Glu Ala Tyr Val
305 310 315 320

Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala Leu Ser Ala His Ala
325 330 335

Leu Met Glu Ala Gly Gly Val Glu Ala Glu Arg His Ala Lys Arg Ala
340 345 350

Leu Asp Trp Leu Lys Pro Leu Gln Val Leu Asp Ile Lys Gly Asp Trp
355 360 365

Ala Ala Ser Lys Pro Asn Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr
370 375 380

Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr Ala Val Val Val Met
385 390 395 400

Ala Met Asp Arg Ala Gln Val Arg Arg Ser Pro Gly Pro Asp Ala Ala
405 410 415

Asp Tyr Gly Gln Ser Ile Ala Arg Ala Arg Glu Trp Val Glu Gly Leu
420 425 430

Gln Ser Arg Asp Gly Gly Trp Ala Ala Phe Asp Ala Asp Asn Thr Tyr
435 440 445

His Tyr Leu Asn Tyr Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp
450 455 460

Pro Pro Thr Ala Asp Val Thr Ala Arg Cys Val Ser Met Leu Ala Gln
465 470 475 480

Leu Gly Glu Thr Arg Glu Ser Cys Pro Pro Leu Asp Arg Gly Val Ala
485 490 495

Tyr Leu Leu Ala Asp Gln Glu Ala Asp Gly Ser Trp Tyr Gly Arg Trp
500 505 510

Gly Met Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala Leu Asn
515 520 525

Ala Ala Gly Val Asp Pro Ala Ser Glu Pro Val Arg Arg Ala Val Asn
530 535 540

Trp Leu Thr Thr Ile Gln Asn Pro Asp Gly Gly Trp Gly Glu Asp Ala
545 550 555 560

Ala Ser Tyr Lys Leu Glu Tyr Arg Gly Tyr Glu Arg Ala Pro Ser Thr
565 570 575

Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala Gly Glu
580 585 590

Ala Asp Ser Pro Ala Val Ala Arg Gly Ile Asn Tyr Leu Thr Arg Ser
595 600 605

Gln Gly Ala Asp Gly Leu Trp Thr Glu Asp Arg Tyr Thr Ala Thr Gly
610 615 620

Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Ala Lys Phe Phe
625 630 635 640

Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu Gln Gln Ser Asn Ser
645 650 655

Arg Arg Val Ala Val Gly Met
660


<210> 169
<211> 667
<212> PRT
<213> Methylobacterium populi

<400> 169
Met Arg Glu Ala Ala Val Ser Lys Val Glu Thr Leu Gln Arg Pro Lys
1 5 10 15

Thr Arg Asp Val Ser Leu Asp Asp Val Glu Arg Gly Val Gln Asn Ala
20 25 30

Ala Arg Ala Leu Thr Glu Met Thr Gln Thr Asp Gly His Ile Cys Phe
35 40 45

Glu Leu Glu Ala Asp Ala Thr Ile Pro Ser Glu Tyr Ile Leu Phe His
50 55 60

Gln Phe Arg Gly Thr Val Pro Arg Asp Gly Leu Glu Ala Lys Ile Gly
65 70 75 80

Asn Tyr Leu Arg Arg Thr Gln Ser Lys Val His Gly Gly Trp Ala Leu
85 90 95

Val His Asp Gly Pro Phe Asp Met Ser Ala Thr Val Lys Ala Tyr Phe
100 105 110

Ala Leu Lys Met Ile Gly Asp Asp Ile Glu Ala Pro His Met Arg Ala
115 120 125

Ala Arg Lys Ala Ile Leu Gln Arg Gly Gly Ala Ala Asn Ala Asn Val
130 135 140

Phe Thr Arg Ile Leu Leu Ala Leu Tyr Gly Glu Val Pro Trp Ala Ala
145 150 155 160

Val Pro Val Met Pro Val Glu Val Met His Leu Pro Lys Trp Phe Pro
165 170 175

Phe His Leu Asp Lys Val Ser Tyr Trp Ala Arg Cys Thr Met Val Pro
180 185 190

Leu Phe Val Ile Gln Ala Lys Lys Pro Arg Ala Lys Asn Pro Arg Gly
195 200 205

Ile Gly Val Ala Glu Leu Phe Val Thr Pro Pro Asp Ser Val Arg Thr
210 215 220

Trp Pro Gly Ser Pro His Ala Thr Trp Pro Trp Thr Pro Ile Phe Gly
225 230 235 240

Ala Ile Asp Arg Val Leu Gln Lys Thr Gln Asp His Phe Pro Lys Val
245 250 255

Pro Arg Gln Arg Ala Ile Asp Lys Ala Val Ala Trp Val Ser Glu Arg
260 265 270

Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ser Met Val Asn
275 280 285

Ser Val Leu Met Tyr Glu Val Leu Gly Tyr Pro Pro Asp His Pro Gln
290 295 300

Val Lys Ile Ala Leu Glu Ala Ile Glu Lys Leu Val Ala Glu Lys Asp
305 310 315 320

Asp Glu Ala Tyr Val Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala
325 330 335

Leu Thr Ser His Ala Met Leu Glu Thr Gly Gly Ala Ala Ala Glu Ala
340 345 350

Asn Ala Arg Ala Gly Leu Asp Trp Leu Lys Pro Leu Gln Ile Leu Asp
355 360 365

Ile Lys Gly Asp Trp Ala Glu Thr Lys Pro Asn Val Arg Pro Gly Gly
370 375 380

Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr
385 390 395 400

Ala Val Val Val Met Ala Met Asp Arg Ala Gln Arg Gln His Gly Leu
405 410 415

Val Ser Gly Met Pro Asp Tyr Ser Ala Ser Ile Ala Arg Ala Arg Glu
420 425 430

Trp Val Glu Gly Leu Gln Ser Ala Asp Gly Gly Trp Ala Ala Phe Asp
435 440 445

Ala Asp Asn Asn His His Tyr Leu Asn His Ile Pro Phe Ser Asp His
450 455 460

Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Val Val
465 470 475 480

Ser Met Leu Ser Gln Leu Gly Glu Thr Arg Glu Thr Ser Arg Ala Leu
485 490 495

Asp Arg Gly Val Thr Tyr Leu Leu Asn Asp Gln Glu Lys Asp Gly Ser
500 505 510

Trp Tyr Gly Arg Trp Gly Met Asn Phe Ile Tyr Gly Thr Trp Ser Val
515 520 525

Leu Cys Ala Leu Asn Ala Ala Gly Val Asp Pro Gln Ser Pro Glu Ile
530 535 540

Arg Lys Ala Val Ala Trp Leu Ile Arg Ile Gln Asn Pro Asp Gly Gly
545 550 555 560

Trp Gly Glu Asp Ala Ser Ser Tyr Lys Leu Asn Pro Glu Phe Glu Pro
565 570 575

Gly Tyr Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Met
580 585 590

Ala Val Gly Glu Val Asp Asp Pro Ala Val Ala Arg Gly Val Asn Tyr
595 600 605

Leu Met Arg Thr Gln Gly Gln Asp Gly Leu Trp Asn Glu Glu Arg Tyr
610 615 620

Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr
625 630 635 640

Pro Lys Phe Phe Pro Leu Trp Ala Met Ala Arg Phe Arg Asn Leu Lys
645 650 655

Lys Gly Asn Ser Arg Gln Val Gln Phe Gly Met
660 665


<210> 170
<211> 665
<212> PRT
<213> Methylobacterium radiotolerans

<400> 170
Met Arg Glu Ala Val Ser Lys Val Glu Ala Leu Gln Arg Ser Lys Thr
1 5 10 15

Gln Gly Ile Ser Leu Glu Asp Val Glu Arg Gly Val Ala Gln Ala Thr
20 25 30

Arg Ala Leu Thr Ala Leu Ala His Asp Asp Gly His Ile Cys Phe Glu
35 40 45

Leu Glu Ala Asp Ala Thr Ile Pro Ser Glu Tyr Ile Leu Phe His His
50 55 60

Phe Arg Gly Thr Gln Val Pro Gly Asp Leu Glu Ala Lys Ile Gly Asn
65 70 75 80

Tyr Leu Arg Arg Thr Gln Gly Arg His Gly Gly Trp Ala Leu Val His
85 90 95

Glu Gly Pro Phe Asp Met Ser Cys Thr Val Lys Ala Tyr Phe Ala Leu
100 105 110

Lys Met Ile Gly Asp Asp Ile Glu Ala Pro His Met Arg Arg Ala Arg
115 120 125

Glu Gly Ile Leu Ser Arg Gly Gly Ala Ala Asn Ala Asn Val Phe Thr
130 135 140

Arg Phe Met Leu Ala Leu Tyr Gly Glu Val Pro Trp Arg Ala Val Pro
145 150 155 160

Val Met Pro Val Glu Val Met Phe Leu Pro Lys Trp Phe Pro Phe His
165 170 175

Leu Asp Lys Ile Ser Tyr Trp Ala Arg Thr Thr Val Val Pro Leu Phe
180 185 190

Val Leu Gln Ala Thr Lys Pro Arg Ala Arg Asn Pro Arg Gly Ile Ser
195 200 205

Val Gln Glu Leu Phe Val Thr Pro Pro Glu Ser Val Arg Ser Trp Pro
210 215 220

Gly Ser Pro His Ala Thr Trp Pro Trp Thr Pro Ile Phe Gly Phe Ile
225 230 235 240

Asp Arg Val Leu Gln Arg Val Glu Asn His Leu Pro Arg Lys Ser Arg
245 250 255

Gln Arg Ala Met Glu Met Ala Arg Ala Trp Val Ser Glu Arg Leu Asn
260 265 270

Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn Ser Val
275 280 285

Leu Met Tyr Glu Val Met Gly Tyr Arg Pro Asp His Pro Gln Val Arg
290 295 300

Val Ala Cys Asp Ala Ile Glu Lys Leu Val Val Glu Lys Ala Asp Glu
305 310 315 320

Ala Tyr Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Leu Ala
325 330 335

Ser His Ala Leu Leu Glu Ala Gly Gly Pro Glu Ala Glu Ala Gln Ala
340 345 350

Arg Ala Gly Leu Asp Trp Leu Lys Pro Arg Gln Val Leu Asp Ile Val
355 360 365

Gly Asp Trp Ala Ala Arg Lys Pro Lys Val Arg Pro Gly Gly Trp Ala
370 375 380

Phe Gln Tyr Ala Asn Ala His Tyr Pro Asp Leu Asp Asp Thr Ala Val
385 390 395 400

Val Val Met Ala Met Asp Arg Ala Met His Gln His Gly Leu Val Ala
405 410 415

Gly Met Pro Asp Tyr Lys Ala Ser Ile Ala Arg Ala Arg Glu Trp Val
420 425 430

Glu Gly Leu Gln Ser Glu Asp Gly Gly Trp Ala Ala Phe Asp Ala Asp
435 440 445

Asn Asn His Met Tyr Leu Asn His Ile Pro Phe Ser Asp His Gly Ala
450 455 460

Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Val Val Gly Met
465 470 475 480

Leu Ser Gln Leu Gly Glu Thr Arg Glu Thr Ser Arg Ala Leu Asp Arg
485 490 495

Gly Val Asn Tyr Leu Leu Asn Asp Gln Glu Glu Asp Gly Ser Trp Tyr
500 505 510

Gly Arg Trp Gly Met Asn Phe Ile Tyr Gly Thr Trp Ser Val Leu Cys
515 520 525

Ala Leu Asn Ala Ala Gly Val Asp Pro Ala Asp Pro Arg Ile Gln Lys
530 535 540

Ala Val Ser Trp Leu Ile Arg Ile Gln Asn Pro Asp Gly Gly Trp Gly
545 550 555 560

Glu Asp Ala Ser Ser Tyr Lys Ile Asp Pro Ala Phe Glu Pro Gly Ser
565 570 575

Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Met Ala Ala
580 585 590

Gly Ala Val Asp Asp Pro Ala Val Thr Arg Gly Ile Asn Phe Leu Thr
595 600 605

Arg Thr Gln Gly Ala Asp Gly Phe Trp Lys Glu Glu Arg Tyr Thr Ala
610 615 620

Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Pro Lys
625 630 635 640

Phe Phe Pro Leu Trp Ala Met Ala Arg Phe Arg Asn Leu Lys Arg Gly
645 650 655

Asn Ser Arg Arg Val Gln Phe Gly Met
660 665


<210> 171
<211> 663
<212> PRT
<213> Methylobacterium sp.

<400> 171
Met Gly Lys Val Glu Thr Leu His Arg Thr Ser Thr Gln Asp Ile Thr
1 5 10 15

Leu Asp Asp Val Glu Arg Arg Val Thr Leu Ala Ser Lys Ala Leu Met
20 25 30

Arg Leu Ala Asn Ala Asp Gly His Trp Cys Phe Glu Leu Glu Ala Asp
35 40 45

Ala Thr Ile Pro Ser Glu Tyr Ile Leu Tyr His His Phe Arg Gly Ser
50 55 60

Ile Pro Thr Ala Glu Leu Glu Gly Lys Ile Ala Ala Tyr Leu Arg Arg
65 70 75 80

Thr Gln Ser Ala Gln His Asp Gly Trp Ala Leu Ile His Asp Gly Pro
85 90 95

Phe Asp Met Ser Ala Thr Val Lys Ala Tyr Phe Ala Leu Lys Met Val
100 105 110

Gly Asp Pro Ile Asp Ala Pro His Met Arg Arg Ala Arg Asp Ala Ile
115 120 125

Leu Arg Arg Gly Gly Ala Ala His Ala Asn Val Phe Thr Arg Ile Met
130 135 140

Leu Ala Leu Tyr Gly Glu Val Pro Trp Thr Ala Val Pro Val Met Pro
145 150 155 160

Val Glu Val Met Leu Leu Pro Arg Trp Phe Pro Phe His Leu Asp Lys
165 170 175

Val Ser Tyr Trp Ala Arg Thr Val Met Val Pro Leu Phe Val Leu Gln
180 185 190

Ala Lys Lys Pro Arg Ala Arg Asn Pro Arg Gly Ile Gly Ile Arg Glu
195 200 205

Leu Phe Val Glu Ala Pro Glu Arg Val Lys Arg Trp Pro Ala Gly Pro
210 215 220

Gln Glu Ser Ser Pro Trp Arg Pro Val Phe Ala Ala Ile Asp Lys Val
225 230 235 240

Leu Gln Lys Val Glu Gly Phe Phe Pro Ala Gly Ser Arg Ala Arg Ala
245 250 255

Ile Asp Lys Ala Val Ala Phe Val Ser Glu Arg Leu Asn Gly Glu Asp
260 265 270

Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn Thr Val Leu Met Phe
275 280 285

Glu Ala Leu Gly Tyr Pro Asp Asp His Pro Phe Ala Val Thr Ala Arg
290 295 300

Ser Ser Val Glu Lys Leu Val Thr Val Lys Glu His Glu Ala Tyr Val
305 310 315 320

Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala Leu Ala Ala His Ala
325 330 335

Leu Met Glu Ala Gly Gly Thr Glu Ala Glu Arg His Ala Lys Arg Ala
340 345 350

Met Asp Trp Leu Lys Pro Leu Gln Val Leu Asp Ile Lys Gly Asp Trp
355 360 365

Ala Ala Ser Lys Pro Asp Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr
370 375 380

Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr Ala Val Val Val Met
385 390 395 400

Ala Met Asp Arg Val Gln Ser Arg Arg Ser Pro Gly Pro Asp Ala Ala
405 410 415

Asp Tyr Gly Leu Ser Ile Ala Arg Ala Arg Glu Trp Val Glu Gly Leu
420 425 430

Gln Ser Arg Asp Gly Gly Trp Ala Ala Phe Asp Ala Asp Asn Thr Tyr
435 440 445

His Tyr Leu Asn Tyr Ile Pro Phe Ser Asp His Gly Ala Leu Leu Asp
450 455 460

Pro Pro Thr Ala Asp Val Thr Ala Arg Cys Val Ser Met Leu Ser Gln
465 470 475 480

Leu Gly Glu Thr Arg Glu Thr Cys Pro Pro Leu Asp Arg Gly Val Ala
485 490 495

Tyr Leu Leu Ala Asp Gln Glu Ala Asp Gly Ser Trp Tyr Gly Arg Trp
500 505 510

Gly Met Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Cys Ala Leu Asn
515 520 525

Ala Ala Gly Ile Asp Pro Ala Cys Glu Pro Val Arg Arg Ala Val Thr
530 535 540

Trp Leu Thr Ala Ile Gln Asn Pro Asp Gly Gly Trp Gly Glu Asp Ala
545 550 555 560

Ser Ser Tyr Lys Leu Glu Tyr Arg Gly Tyr Glu Arg Ala Pro Ser Thr
565 570 575

Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Met Ala Ala Gly Glu
580 585 590

Ala Asp Asn Pro Ala Val Ala Arg Gly Ile Asn Tyr Leu Thr Arg Thr
595 600 605

Gln Gly Ala Asp Gly Leu Trp Ala Glu Asp Arg Tyr Thr Ala Thr Gly
610 615 620

Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Ala Lys Phe Phe
625 630 635 640

Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu Gln Arg Gly Asn Ser
645 650 655

Leu Lys Val Ala Val Gly Met
660


<210> 172
<211> 672
<212> PRT
<213> Methylocella silvestris

<400> 172
Met Asp Asp Arg Val Gly Ala Ala Thr Phe Glu Ala Gln Pro Arg Ala
1 5 10 15

Gly Phe Gly Ser Val Glu Ala Ala Ile Ser Arg Ala Arg Glu Ala Leu
20 25 30

Leu Ala Val Gln Lys Pro Asp Gly His Phe Val Phe Glu Leu Glu Ala
35 40 45

Asp Val Ser Ile Pro Ala Glu Tyr Ile Leu Phe Arg His Phe Leu Gly
50 55 60

Asp Pro Ala Lys Thr Glu Ile Glu Arg Lys Ile Gly Val Tyr Leu Arg
65 70 75 80

Arg Arg Gln Thr Ala Ala Gly Gly Trp Pro Leu Phe Ala Glu Gly Val
85 90 95

Phe Asn Val Ser Ser Ser Val Lys Ala Tyr Phe Ala Leu Lys Ile Ile
100 105 110

Gly Asp Asp Pro Asn Ala Pro His Met Ala Lys Ala Arg Asn Ala Ile
115 120 125

Leu Ala His Gly Gly Ala Ala Gln Ser Asn Val Phe Thr Arg Ser Leu
130 135 140

Leu Ala Leu Tyr Gly Glu Val Pro Trp Arg Ala Val Pro Ala Met Pro
145 150 155 160

Val Glu Ile Met His Leu Pro Arg Trp Phe Pro Phe His Leu Ser Lys
165 170 175

Val Ser Tyr Trp Gly Arg Thr Val Ile Ala Pro Leu Ile Val Val His
180 185 190

Ala Leu Lys Pro Arg Ala Lys Asn Pro Arg Lys Ile Ser Val Ser Glu
195 200 205

Leu Phe Val Ala Pro Ala Glu Thr Val Ser Arg Trp Pro Gly Ala Pro
210 215 220

His Lys Ser Phe Pro Trp Thr Thr Ile Phe Gly Ala Ile Asp Arg Val
225 230 235 240

Leu His Lys Thr Glu Pro Leu Leu Pro Ala Arg Ser His Gln Thr Ala
245 250 255

Ile Asp Lys Ala Val Ala Phe Val Thr Ala Arg Leu Asn Gly Glu Asp
260 265 270

Gly Leu Gly Ala Ile Tyr Pro Ala Met Ala Tyr Ser Ala Met Met Phe
275 280 285

Phe Ala Leu Gly Ala Pro Leu Ser Asp Pro Arg Ile Val Gln Ile Arg
290 295 300

Lys Ala Ile Asp Arg Leu Leu Val Ile Lys Asp Gly Glu Ala Tyr Cys
305 310 315 320

Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Leu Ala Ser His Ala
325 330 335

Leu Met Glu Ser Ala Gly Gln Arg Pro Glu Ala Arg Thr Ala Pro Ala
340 345 350

Ala Ala Ala Val Phe Glu Ala Leu Asp Trp Leu Lys Pro Leu Gln Val
355 360 365

Leu Asp Val Lys Gly Asp Trp Ala Thr Gln Asn Pro Asp Val Arg Pro
370 375 380

Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp
385 390 395 400

Asp Thr Ala Val Val Val Leu Ala Met Asp Arg Ala Val Lys Thr Ser
405 410 415

Pro Leu Ile Ala Gly Glu Glu Glu Thr Ala Tyr Val Glu Ala Ile Ser
420 425 430

Arg Ala Arg Glu Trp Ile Leu Gly Leu Gln Ser Ala Asn Gly Gly Phe
435 440 445

Gly Ala Phe Asp Ala Asp Asn Asp Arg Asp Tyr Leu Asn Tyr Ile Pro
450 455 460

Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Thr
465 470 475 480

Ala Arg Cys Val Ser Met Leu Gly Gln Leu Gly Glu Arg Pro Glu Thr
485 490 495

Ser Pro Ala Leu Ala Arg Ala Ile Asp Tyr Leu Leu Ser Glu Gln Glu
500 505 510

Glu Glu Gly Ser Trp Phe Gly Arg Trp Gly Met Asn Tyr Ile Tyr Gly
515 520 525

Thr Trp Ser Val Leu Ser Ala Phe Asn Ala Val Glu Arg Pro Ala Asp
530 535 540

Cys Ala Ala Thr Arg Lys Ala Ala Ala Trp Leu Lys Arg Ile Gln Asn
545 550 555 560

Pro Asp Gly Gly Trp Gly Glu Asp Gly Glu Ser Tyr Ala Leu Gly Tyr
565 570 575

Lys Gly Tyr Asn Pro Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala
580 585 590

Leu Leu Ala Leu Met Ala Ala Gly Glu Val Asp Ala Pro Glu Val Ala
595 600 605

Leu Gly Leu Asp Tyr Leu Val Ser Thr Gln Ala Asp Asp Gly Phe Trp
610 615 620

Asp Glu Ala Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu
625 630 635 640

Arg Tyr His Gly Tyr Ala Lys Phe Phe Pro Leu Trp Ala Met Ala Arg
645 650 655

Tyr Arg Asn Leu Lys Ser Gly Asn Arg Leu Lys Thr Gln Phe Gly Met
660 665 670




<210> 173
<211> 654
<212> PRT
<213> Methylococcus capsulatus

<220>
<221> misc_feature
<222> (591)..(591)
<223> Xaa can be any amino acid

<400> 173
Met Leu Arg Glu Ala Thr Ala Ile Ser Asn Leu Glu Pro Pro Leu Thr
1 5 10 15

Ala Ser Tyr Val Glu Ser Pro Leu Asp Ala Ala Ile Arg Gln Ala Lys
20 25 30

Asp Arg Leu Leu Ser Leu Gln His Leu Glu Gly Tyr Trp Val Phe Glu
35 40 45

Leu Glu Ala Asp Cys Thr Ile Pro Ala Glu Tyr Ile Leu Met Met His
50 55 60

Phe Met Asp Glu Ile Asp Ala Ala Leu Gln Ala Lys Ile Ala Asn Tyr
65 70 75 80

Leu Arg His His Gln Ser Ala Asp Gly Ser Tyr Pro Leu Phe Arg Gly
85 90 95

Gly Ala Gly Asp Ile Ser Cys Thr Val Lys Val Tyr Tyr Ala Leu Lys
100 105 110

Leu Ala Gly Asp Ser Ile Asp Ala Pro His Met Lys Lys Ala Arg Glu
115 120 125

Trp Ile Leu Ala Gln Gly Gly Ala Ala Arg Ser Asn Val Phe Thr Arg
130 135 140

Ile Met Leu Ala Met Phe Glu Gln Ile Pro Trp Arg Gly Ile Pro Phe
145 150 155 160

Thr Pro Val Glu Ile Met Leu Leu Pro Lys Trp Phe Pro Phe His Leu
165 170 175

Asp Lys Val Ser Tyr Trp Ser Arg Thr Val Met Val Pro Leu Phe Ile
180 185 190

Leu Cys Ser His Lys Val Thr Ala Arg Asn Pro Ser Arg Ile His Val
195 200 205

Arg Glu Leu Phe Thr Val Glu Pro Gln Lys Glu Arg His Tyr Phe Asp
210 215 220

His Val Lys Thr Pro Leu Gly Lys Ala Ile Leu Ala Leu Glu Arg Phe
225 230 235 240

Gly Arg Met Leu Glu Pro Leu Ile Pro Lys Ala Val Arg Lys Lys Ala
245 250 255

Thr Gln Lys Ala Phe Asp Trp Phe Thr Ala Arg Leu Asn Gly Val Asp
260 265 270

Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn Ala Tyr Glu Ala Leu
275 280 285

Asp Phe Leu Gly Val Pro Pro Asp Asp Glu Arg Arg Arg Leu Ala Arg
290 295 300

Glu Ser Ile Asp Arg Leu Leu Val Phe Gln Gly Asp Ser Val Tyr Cys
305 310 315 320

Gln Pro Cys Val Ser Pro Ile Trp Asp Thr Ala Leu Thr Ser Leu Thr
325 330 335

Leu Gln Glu Val Ala Arg His Thr Ala Asp Leu Arg Leu Asp Ala Ala
340 345 350

Leu Ser Lys Gly Leu Lys Trp Leu Ala Ser Lys Gln Ile Asp Lys Asp
355 360 365

Ala Pro Gly Asp Trp Arg Val Asn Arg Ala Gly Leu Glu Gly Gly Gly
370 375 380

Trp Ala Phe Gln Phe Gly Asn Asp Tyr Tyr Pro Asp Val Asp Asp Ser
385 390 395 400

Ala Val Val Ala His Ala Leu Leu Gly Ser Glu Asp Pro Ser Phe Asp
405 410 415

Asp Asn Leu Arg Arg Ala Ala Asn Trp Ile Ala Gly Met Gln Ser Arg
420 425 430

Asn Gly Gly Phe Gly Ala Phe Asp Ala Asp Asn Thr Tyr Tyr Tyr Leu
435 440 445

Asn Ser Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr
450 455 460

Ala Asp Val Ser Ala Arg Cys Ala Met Phe Leu Ala Arg Trp Val Asn
465 470 475 480

Arg Gln Pro Glu Leu Arg Pro Val Leu Glu Arg Thr Ile Asp Tyr Leu
485 490 495

Arg Arg Glu Gln Glu Ala Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr
500 505 510

Asn Tyr Ile Tyr Gly Pro Gly Ala Val Leu Leu Ala Tyr Glu Gly Arg
515 520 525

Arg Val Pro Asn Asp Asp Pro Ser Val Arg Arg Ala Val Ala Trp Leu
530 535 540

Lys Ser Ile Gln Arg Glu Asp Gly Gly Trp Gly Glu Asp Asn Phe Ser
545 550 555 560

Tyr His Asp Pro Ser Tyr Arg Gly Arg Phe His Thr Ser Thr Ala Phe
565 570 575

Gln Thr Gly Phe Ala Leu Ile Ala Leu Met Ala Ala Gly Glu Xaa Gly
580 585 590

Ser Pro Glu Val Gln Ala Gly Val Asp Tyr Leu Leu Arg Gln Gln Arg
595 600 605

Pro Asp Gly Phe Trp Asn Asp Glu Cys Phe Thr Ala Pro Gly Phe Pro
610 615 620

Arg Val Phe Tyr Leu Lys Tyr His Gly Tyr Asp Lys Phe Phe Pro Leu
625 630 635 640

Trp Ala Leu Ala Arg Tyr Arg Asn Glu Arg Tyr Ala Leu Ala
645 650


<210> 174
<211> 635
<212> PRT
<213> Microcystis aeruginosa

<400> 174
Met Gln Ile Gln Asp Lys Ile Thr Glu Ile Ala Ala Lys Thr Ala Lys
1 5 10 15

Ala Ile Glu Leu Ser Gln Asn Tyr Leu Leu Ser Thr Gln Tyr Ser Glu
20 25 30

Gly Tyr Trp Trp Ala Glu Leu Glu Ser Asn Val Thr Ile Thr Ser Glu
35 40 45

Ala Ile Leu Leu His Lys Ile Trp Lys Thr Asp Lys Lys Arg Pro Leu
50 55 60

Asp Lys Ala Ala Thr Tyr Leu Arg Gln Gln Gln Cys Pro Asn Gly Ala
65 70 75 80

Trp Glu Leu Phe Tyr Gly Asp Gly Gly Asp Leu Ser Thr Thr Val Glu
85 90 95

Ala Tyr Met Gly Leu Arg Leu Leu Gly Ile Pro Ala Asn Asp Pro Ala
100 105 110

Leu Glu Lys Ala Arg Glu Phe Ile Leu Ala Lys Gly Gly Ile Ser Lys
115 120 125

Thr Arg Ile Phe Thr Lys Met His Leu Ala Leu Ile Gly Cys Tyr Asp
130 135 140

Trp Gln Gly Val Pro Ser Ile Pro Ala Trp Ile Met Leu Leu Pro Glu
145 150 155 160

Asn Phe Pro Phe Thr Ile Tyr Glu Met Ser Ser Trp Ala Arg Gly Ser
165 170 175

Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys Pro Val Tyr Lys Met
180 185 190

Gly Phe Asn Leu Asp Glu Leu Tyr Thr Glu Gly Val Asn Asn Val Lys
195 200 205

Tyr Glu Leu Pro Lys Asn Asn Asn Trp Ser Asp Val Phe Leu Trp Leu
210 215 220

Asp Gly Leu Phe Lys Trp Ala Glu Lys Thr Asp Leu Val Pro Phe Arg
225 230 235 240

Gln Glu Ser Leu Lys Ala Ala Glu Lys Trp Val Ile Glu Arg Gln Glu
245 250 255

Asp Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn Ser Leu
260 265 270

Leu Ala Leu Lys Ala Leu Asp Tyr Asp Val Tyr Asp Pro Ile Val Ala
275 280 285

Arg Gly Leu Lys Ala Val Asp Asn Phe Ala Ile Glu Thr Asp Asn Thr
290 295 300

Tyr Cys Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Trp Val
305 310 315 320

Ile Arg Ser Leu Ile Glu Ser Gly Leu Asn Pro Ala His Pro Ala Met
325 330 335

Ile Lys Ala Gly Gln Trp Leu Ile Asp Gln Gln Ile Leu Asp Tyr Gly
340 345 350

Asp Trp Ala Ile Lys Asn Lys Ile Gly Thr Pro Gly Gly Trp Ala Phe
355 360 365

Glu Phe Asp Asn Arg Trp Tyr Pro Asp Leu Asp Asp Ser Ala Val Val
370 375 380

Val Met Ala Leu Glu Leu Ile Lys Met Pro Asp Glu Asn Ile Lys Thr
385 390 395 400

Ser Val Met Lys Arg Ala Val Asn Trp Met Ala Thr Met Gln Cys Lys
405 410 415

Ala Gly Gly Trp Gly Ala Phe Asp Ile Asp Asn Asp Gln Asn Trp Leu
420 425 430

Asn Ser Leu Pro Tyr Ala Asp Leu Lys Ala Met Ile Asp Pro Asn Thr
435 440 445

Ala Asp Val Thr Ala Arg Val Leu Glu Met Leu Gly Thr Cys Asp Val
450 455 460

Lys Met Gly Glu Asn Arg Val Lys Lys Ala Leu Asp Tyr Leu Glu Lys
465 470 475 480

Glu Gln Glu Ala Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr
485 490 495

Ile Tyr Gly Thr Ser Gly Ala Leu Ser Ala Leu Ala Phe Leu Glu Pro
500 505 510

Asn Gln Tyr Arg Gln Gln Leu Gln Lys Gly Ala Asn Trp Leu Ser Ser
515 520 525

Cys Gln Asn Val Asp Gly Gly Trp Gly Glu Thr Cys Phe Ser Tyr Asn
530 535 540

Asn Pro Lys Phe Lys Gly Gln Gly Asn Ser Thr Ala Ser Gln Thr Ala
545 550 555 560

Trp Ala Leu Ile Gly Leu Leu Ala Val Gly Lys Val Thr Gly Asn Tyr
565 570 575

Gln Arg Glu Val Ile Glu Lys Gly Val Asn Tyr Leu Leu Val Thr Gln
580 585 590

Lys Glu Asn Gly Thr Trp Asp Glu Asp Tyr Phe Thr Gly Thr Gly Phe
595 600 605

Pro Cys His Phe Tyr Leu Lys Tyr His Phe Tyr Gln Gln Tyr Phe Pro
610 615 620

Leu Leu Ala Leu Gly Arg Tyr Arg Ala Leu Ile
625 630 635


<210> 175
<211> 695
<212> PRT
<213> Neosartorya fischeri

<400> 175
Met Leu Gln Thr Glu Ala Ile Thr Thr Glu Gly Leu Arg Phe Arg Ser
1 5 10 15

Leu Ala Pro Asp Asp Pro Leu Leu Pro Arg Val Lys Gln Ala Leu Lys
20 25 30

Leu Ser Gly Gln His Ser Arg Glu Glu Met His Ser Asp Gly His Trp
35 40 45

Cys Gly Glu Val Lys Thr Asn Ala Thr Thr Ser Ala Glu His Val Leu
50 55 60

Leu Cys Gln Ala Leu Asp Ile Asn Leu Asp Ala Asp Arg Glu Ala Phe
65 70 75 80

Ile Ser Trp Phe Arg Cys Thr Gln Gly Ala Asp Gly Gly Trp Ser Thr
85 90 95

Ala Pro Asp Gln Ala Gly Asp Ile Ser Val Thr Val Glu Ala Tyr Leu
100 105 110

Ala Leu Lys Ile Leu Gly Leu Ser Glu Asp Asp Ala Ala Met Arg Ser
115 120 125

Ala Arg Asp Phe Ala Ile Ala Ala Gly Gly Val Ala Arg Val Arg Ile
130 135 140

Phe Thr Arg Ile Tyr Leu Ala Met Phe Gly Leu Phe Pro Trp Ala Ala
145 150 155 160

Val Pro Glu Leu Pro Pro Glu Leu Ile Leu Leu Pro Ser Arg Val Pro
165 170 175

Val Ser Ile Tyr His Trp Ser Ala Trp Ala Arg Ala Thr Val Val Pro
180 185 190

Leu Leu Ile Ile Ser His His Arg Pro Ile Tyr Ala Leu Pro Gly Gly
195 200 205

Lys Ala Thr Cys Ser Asp Tyr Leu Asp Glu Leu Trp Cys Asp Pro Arg
210 215 220

Asn Lys Met Val Pro Tyr Asn His Asp Lys Pro Thr Ala Trp Arg Ser
225 230 235 240

Asp Pro Phe Ala Leu Ile Phe Thr Leu Ala Asp Ser Ile Leu His Arg
245 250 255

Leu Asp Gly Leu Arg Ser Phe Asn Pro Leu Arg Arg Phe Ala Leu Arg
260 265 270

Lys Cys Val Asp Trp Ile Leu Glu His Gln Glu Asp Met Gly Asp Ile
275 280 285

Gly Asp Ile Met Pro Pro Leu His Gly Ala Met Leu Ala Leu Arg Leu
290 295 300

Glu Gly Tyr Pro Leu His Ser Asp Pro Ile His Arg Gly Leu Glu Ala
305 310 315 320

Ile Glu Arg Phe Ala Tyr Arg Asp Gln Gln Gly Lys Arg Ile Gln Thr
325 330 335

Thr Val Ser Ala Phe Trp Asp Thr Ser Leu Met Leu Val Ala Leu Gly
340 345 350

Asp Ala Gly Met Ala Ser Ser Pro Trp Leu Thr Arg Ser Leu Gly Trp
355 360 365

Leu Gln Gln His Gln Arg Leu Gly Asn Tyr Gly Asp Trp Lys Val Asn
370 375 380

Asn Pro Gly Leu Lys Ala Gly Gly Phe Ser Phe Gly Tyr Phe Asn Thr
385 390 395 400

Trp Tyr Pro Asp Val Asp Asp Thr Ala Ser Ala Val Leu Ala Ile Ile
405 410 415

Arg Gln Asp Glu Arg Leu Val Cys Ser Ala Ser Val Leu Asp Ala Leu
420 425 430

Asn Trp Leu Leu Gly Met Gln Asn Thr Asp Gly Gly Trp Gly Ala Phe
435 440 445

Asp Arg Asp Asn Asn Lys Leu Phe Leu Asn Lys Ile Pro Phe Ser Asp
450 455 460

Met Glu Ala Phe Cys Asp Pro Ser Thr Pro Asp Val Thr Gly His Val
465 470 475 480

Leu Glu Ala Phe Gly Ile Phe Leu Ala Val Ser Ala Arg Gln Gln Ser
485 490 495

Pro Thr Lys Ala Asp Val Leu Thr Asp Arg Ile Val Ser Ala Ser Arg
500 505 510

Arg Ala Ile Cys Tyr Leu Ser Asp Thr His Val Ser Ser Gly Gly Trp
515 520 525

Tyr Gly Arg Trp Gly Cys Asn Tyr Ile Tyr Gly Thr Ser Ala Val Leu
530 535 540

Cys Ala Leu Ala Tyr Phe Gly Ser Lys Ser Asp Thr Leu Ser Gly Val
545 550 555 560

Arg Ser Val Lys Asp Ala Val Asn Gln Ala Ile Arg Trp Leu Glu Thr
565 570 575

Val Gln Asn Gln Asp Gly Gly Trp Gly Glu Thr Val Asn Ser Tyr Lys
580 585 590

Asp Pro Ser Arg Ala Gly Ser Gly Pro Ser Thr Ala Ser Gln Thr Ala
595 600 605

Trp Ala Ile Met Ala Leu Leu Pro Tyr Leu Pro Pro Ser Thr Glu Val
610 615 620

Ile Gln Arg Gly Val Glu Tyr Leu Leu Arg Thr Gln Thr Lys Thr Ala
625 630 635 640

Ser Gln Gly Ala Thr Trp His Glu Lys Ala Tyr Thr Gly Thr Gly Phe
645 650 655

Pro Lys Tyr Phe Tyr Met Gly Tyr Ser Phe Tyr Cys His Tyr Phe Pro
660 665 670

Met Met Ala Leu Gly Arg Tyr Ala Tyr Pro Cys Pro Glu Trp His Glu
675 680 685

Asn Trp Arg Pro Lys Lys Glu
690 695


<210> 176
<211> 654
<212> PRT
<213> Nitrobacter hamburgensis

<400> 176
Met Asn Ser Val Asn Ala Thr Val Ala Pro Ile Asp Asp Ala Ala Leu
1 5 10 15

Gly Gly Ser Ile Gly Ala Ala Thr Arg Gly Leu Leu Asp Leu Lys Gln
20 25 30

Pro Asp Gly His Phe Val Phe Glu Leu Glu Ala Asp Ala Thr Ile Pro
35 40 45

Ser Glu Tyr Val Leu Leu Arg His Tyr Leu Gly Glu Pro Val Asp Ala
50 55 60

Ala Leu Glu Ala Lys Ile Ala Val Tyr Leu Arg Arg Ile Gln Gly Ala
65 70 75 80

His Gly Gly Trp Pro Leu Val His Asp Gly Pro Phe Asp Met Ser Ala
85 90 95

Ser Val Lys Ala Tyr Phe Ala Leu Lys Met Ile Gly Asp Ser Ile Asp
100 105 110

Ala Pro His Met Ala Arg Ala Arg Glu Ala Ile Leu Ser Arg Gly Gly
115 120 125

Ala Ala Asn Val Asn Val Phe Thr Arg Phe Leu Leu Ser Leu Phe Glu
130 135 140

Val Leu Thr Trp Arg Ser Ala Pro Val Leu Pro Ile Glu Ile Met Leu
145 150 155 160

Leu Pro Met Trp Ser Pro Phe His Ile Asn Lys Ile Ser Tyr Trp Ala
165 170 175

Arg Thr Thr Met Val Pro Leu Met Val Leu Ala Ala Leu Lys Pro Arg
180 185 190

Ala Arg Asn Pro Arg Gly Ile Gly Ile Arg Glu Leu Phe Leu Gln Asp
195 200 205

Pro Ala Thr Val Gly Thr Pro Lys Arg Ala Pro His Gln Ser Pro Ala
210 215 220

Trp Phe Thr Leu Phe Asn Ser Leu Asp Trp Ile Leu Arg Lys Ile Glu
225 230 235 240

Pro Leu Phe Pro Lys Arg Leu Arg Ala Arg Ala Ile Glu Lys Ala Ile
245 250 255

Ala Phe Val Glu Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile
260 265 270

Phe Pro Pro Met Val Asn Thr Val Met Met Tyr Asp Ala Leu Gly Phe
275 280 285

Pro Pro Glu His Pro Pro Arg Ala Val Ala Arg Arg Gly Ile Asp Lys
290 295 300

Leu Leu Val Ile Gly Lys Asp Glu Ala Tyr Cys Gln Pro Cys Val Ser
305 310 315 320

Pro Ile Trp Asp Thr Ala Leu Thr Cys His Ala Leu Leu Glu Ala Gly
325 330 335

Gly Pro Glu Ala Leu Ser Gly Ala Gly Lys Ser Leu Asp Trp Leu Leu
340 345 350

Pro Lys Gln Glu Leu Val Leu Lys Gly Asp Trp Ala Val Lys Arg Pro
355 360 365

Asp Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Ala His Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Met Asp Arg Val
385 390 395 400

Arg Arg Asn Asp Arg Ser Asp Lys Tyr Asn Glu Ala Ile Ala Arg Gly
405 410 415

Arg Glu Trp Ile Glu Gly Met Gln Ser Arg Asp Gly Gly Phe Ala Ala
420 425 430

Phe Asp Ala Asp Asn Leu Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ser
435 440 445

Asp His Ala Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg
450 455 460

Cys Val Ser Met Leu Ala Gln Leu Gly Glu Thr Val Arg Ser Ser Pro
465 470 475 480

Ser Met Ala Ala Gly Val Asp Tyr Leu Arg Arg Thr Gln Leu Lys Glu
485 490 495

Gly Ser Trp Tyr Gly Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp
500 505 510

Ser Val Val Cys Ala Leu Asn Ala Ala Gly Val Asp His Gln Asp Pro
515 520 525

Ala Met Arg Lys Ala Val Asp Trp Leu Val Ser Ile Gln Asn Ala Asp
530 535 540

Gly Gly Trp Gly Glu Asp Ala Val Ser Tyr Arg Leu Asp Tyr Lys Gly
545 550 555 560

Phe Glu Gly Ala Pro Thr Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu
565 570 575

Ala Leu Met Ala Ala Gly Glu Val Glu Asn Pro Ala Val Ala Arg Gly
580 585 590

Met Lys Tyr Leu Ile Asp Thr Gln Thr Lys Lys Gly Leu Trp Asp Glu
595 600 605

Gln Arg Phe Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr
610 615 620

His Gly Tyr Ser Arg Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg
625 630 635 640

Asn Leu Arg Ser Thr Asn Ser Lys Val Val Gly Val Gly Met
645 650


<210> 177
<211> 651
<212> PRT
<213> Nitrobacter sp.

<400> 177
Met Asn Ala Thr Val Ala Gln Ile Gly Asp Ala Val Leu Glu Asp Arg
1 5 10 15

Ile Gly Ser Ala Thr Arg Gly Leu Leu Asn Leu Lys Gln Ser Asp Gly
20 25 30

His Phe Val Phe Glu Leu Glu Ala Asp Ala Thr Ile Pro Ser Glu Tyr
35 40 45

Ile Leu Leu Arg His Tyr Leu Gly Glu Pro Val Asp Thr Val Leu Glu
50 55 60

Ala Lys Ile Ala Ala Tyr Leu Arg Arg Ile Gln Gly Ala His Gly Gly
65 70 75 80

Trp Pro Leu Val His Asp Gly Pro Phe Asp Met Ser Ala Ser Val Lys
85 90 95

Ala Tyr Phe Ala Leu Lys Met Ile Gly Asp Ser Val Asp Ala Pro His
100 105 110

Met Ala Arg Ala Arg Glu Ala Ile Leu Ser Arg Gly Gly Ala Ala Asn
115 120 125

Val Asn Val Phe Thr Arg Phe Leu Leu Ser Phe Phe Glu Val Leu Thr
130 135 140

Trp Arg Ser Val Pro Val Leu Pro Val Glu Ile Met Leu Leu Pro Met
145 150 155 160

Trp Ser Pro Phe His Leu Asn Lys Ile Ser Tyr Trp Ala Arg Thr Thr
165 170 175

Met Val Pro Leu Met Val Leu Ala Val Leu Lys Pro Arg Ala Arg Asn
180 185 190

Pro Arg Asp Val Gly Ile Arg Glu Leu Phe Leu Gln Asp Pro Ala Thr
195 200 205

Val Arg Thr Pro Lys Arg Ala Pro His Gln Ser Pro Ala Trp Phe Ala
210 215 220

Leu Phe Ser Ser Leu Asp Trp Ile Leu Arg Arg Ile Glu Pro Leu Phe
225 230 235 240

Pro Lys Arg Leu Arg Ala Arg Ala Met Glu Lys Ala Ile Ala Phe Val
245 250 255

Glu Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe Pro Pro
260 265 270

Met Val Asn Thr Val Met Met Tyr Asp Ala Leu Gly Phe Pro Pro Glu
275 280 285

His Pro Pro Arg Ala Val Thr Arg Arg Gly Ile Asp Lys Leu Leu Val
290 295 300

Ile Gly Glu Asp Glu Ala Tyr Cys Gln Pro Cys Val Ser Pro Ile Trp
305 310 315 320

Asp Thr Ala Leu Ser Cys His Ala Leu Leu Glu Ala Gly Ala Pro Glu
325 330 335

Ala Leu Asn Ser Ala Gly Lys Cys Leu Asp Trp Leu Leu Pro Lys Gln
340 345 350

Glu Leu Val Leu Lys Gly Asp Trp Ala Ala Lys Arg Pro Asp Val Arg
355 360 365

Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Gly His Tyr Pro Asp Leu
370 375 380

Asp Asp Thr Ala Val Val Val Met Ala Met Asp Arg Val Arg Arg Asn
385 390 395 400

Gly Arg Gly Asp Lys Tyr Asp Glu Ala Ile Glu Arg Gly Arg Glu Trp
405 410 415

Ile Glu Gly Met Gln Ser Arg Asp Gly Gly Phe Ala Ala Phe Asp Ala
420 425 430

Asp Asn Leu Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ser Asp His Ala
435 440 445

Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg Cys Val Ser
450 455 460

Met Leu Ala Gln Leu Gly Ala Thr Val Asp Gly Ser Ser Ser Met Ala
465 470 475 480

Ala Gly Val Glu Tyr Leu Arg Arg Thr Gln Leu Ala Glu Gly Ser Trp
485 490 495

Tyr Gly Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu
500 505 510

Cys Ala Leu Asn Ala Ala Gly Val Asp His Gln Asp Pro Ala Ile Arg
515 520 525

Lys Ala Val Asp Trp Leu Leu Ser Ile Gln Asn Glu Asp Gly Gly Trp
530 535 540

Gly Glu Asp Ala Val Ser Tyr Arg Leu Asp Tyr Lys Gly Phe Glu Gly
545 550 555 560

Ala Pro Thr Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Met
565 570 575

Ala Ala Gly Glu Val Glu Asn Pro Ala Val Thr Arg Gly Ile Lys Tyr
580 585 590

Leu Ile Asp Thr Gln Thr Lys Lys Gly Leu Trp Asp Glu Gln Arg Tyr
595 600 605

Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr
610 615 620

Ser Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn Leu Arg
625 630 635 640

Ser Thr Asn Ser Lys Val Val Gly Val Gly Met
645 650


<210> 178
<211> 654
<212> PRT
<213> Nitrobacter winogradskyi

<400> 178
Met Asn Ser Ile Asn Ala Thr Ala Ala Pro Ile Asp Asp Asn Val Leu
1 5 10 15

Gly Asp Arg Ile Gly Ala Ala Thr Arg Gly Leu Leu Ser Leu Lys Gln
20 25 30

Ser Asp Gly His Phe Val Phe Glu Leu Glu Ala Asp Ala Thr Ile Pro
35 40 45

Ser Glu Tyr Ile Leu Met Arg His Tyr Leu Gly Glu Pro Val Asp Thr
50 55 60

Val Leu Glu Ala Lys Ile Ala Ala Tyr Leu Arg Arg Ile Gln Gly Ala
65 70 75 80

His Gly Gly Trp Pro Leu Val His Asp Gly Pro Phe Asp Met Ser Ala
85 90 95

Ser Val Lys Ala Tyr Phe Ala Leu Lys Met Ala Gly Asp Ser Ile Asp
100 105 110

Ala Pro His Met Ala Arg Ala Arg Glu Ala Ile Leu Ser Arg Gly Gly
115 120 125

Ala Ala Asn Val Asn Val Phe Thr Arg Phe Leu Leu Ser Phe Phe Gly
130 135 140

Glu Leu Thr Trp Arg Ser Val Pro Val Leu Pro Val Glu Ile Met Leu
145 150 155 160

Leu Pro Met Trp Ser Pro Phe His Leu Asn Lys Val Ser Tyr Trp Ala
165 170 175

Arg Thr Thr Met Val Pro Leu Met Val Leu Ala Ala Leu Lys Pro Arg
180 185 190

Ala Arg Asn Pro Arg Gly Ile Gly Ile Arg Glu Leu Phe Leu Glu Asp
195 200 205

Pro Ala Thr Val Gly Thr Pro Lys Arg Ala Pro His Gln Ser Pro Gly
210 215 220

Trp Phe Ala Leu Phe Thr Gly Phe Asp Arg Val Leu Arg Leu Ile Glu
225 230 235 240

Pro Leu Ser Pro Lys Trp Leu Arg Ala Arg Ala Met Lys Lys Ala Ile
245 250 255

Ala Phe Val Glu Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile
260 265 270

Phe Pro Pro Met Val Asn Thr Val Met Met Tyr Asp Ala Leu Gly Phe
275 280 285

Pro Pro Glu His Pro Pro Arg Ala Val Thr Arg Arg Gly Ile Asp Lys
290 295 300

Leu Leu Val Val Gly Glu Asn Glu Ala Tyr Cys Gln Pro Cys Val Ser
305 310 315 320

Pro Ile Trp Asp Thr Ala Leu Ser Cys His Ala Leu Leu Glu Ala Gly
325 330 335

Gly Pro Glu Ala Val Asn Ser Ala Gly Lys Cys Leu Asp Trp Leu Leu
340 345 350

Leu Lys Gln Glu Leu Val Leu Lys Gly Asp Trp Ala Val Lys Arg Pro
355 360 365

Asp Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Gly His Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Met Asp Arg Val
385 390 395 400

Arg Arg Asn Gly Pro Asn Gly Arg Tyr Asp Glu Ala Ile Ala Arg Gly
405 410 415

Arg Glu Trp Ile Glu Gly Met Gln Ser Arg Asp Gly Gly Phe Ala Ala
420 425 430

Phe Asp Ala Asp Asn Leu Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ser
435 440 445

Asp His Ala Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg
450 455 460

Cys Val Ser Met Leu Ala Gln Leu Gly Glu Thr Val Asp Ser Ser Ser
465 470 475 480

Ser Met Ala Ala Gly Val Glu Tyr Leu Arg Arg Thr Gln Leu Ala Glu
485 490 495

Gly Ser Trp Tyr Gly Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp
500 505 510

Ser Val Leu Cys Ala Leu Asn Val Ala Gly Val Asp His Gln Asp Pro
515 520 525

Val Ile Arg Arg Ala Val Asn Trp Leu Val Ser Ile Gln Asn Ala Asp
530 535 540

Gly Gly Trp Gly Glu Asp Ala Val Ser Tyr Arg Leu Asp Tyr Lys Gly
545 550 555 560

Phe Glu Gly Ala Pro Thr Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu
565 570 575

Ala Leu Met Ala Ala Gly Glu Val Glu Asn Pro Ala Val Ala Arg Gly
580 585 590

Ile Lys Tyr Leu Ile Asp Thr Gln Thr Lys Lys Gly Leu Trp Asp Glu
595 600 605

Gln Arg Tyr Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr
610 615 620

His Gly Tyr Ser Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg
625 630 635 640

Asn Leu Arg Ser Thr Asn Ser Lys Ala Val Gly Val Gly Met
645 650


<210> 179
<211> 652
<212> PRT
<213> Nitrococcus mobilis

<400> 179
Met Glu Gln Gln Pro Glu Leu Ile Ser Gly Gly Val Gly Gly Val Ala
1 5 10 15

Tyr Pro Trp Asp Leu Gly Ser Gln Ala Ile Glu Glu Ala Ile Leu Ala
20 25 30

Ala Arg Ala Ala Leu Leu Ala His Leu His Pro Asp Gly Tyr Trp Cys
35 40 45

Phe Glu Leu Glu Ala Asp Cys Thr Ile Pro Ala Glu Tyr Ile Met Met
50 55 60

Met His Tyr Thr Gly Glu Leu Glu Ala Ala Leu Glu Leu Lys Leu Ala
65 70 75 80

Arg Tyr Ile Arg Glu Cys Gln Leu Gln Glu Gly Gly Trp Pro Leu Tyr
85 90 95

Tyr Gly Gly Ala Met Asp Ile Ser Cys Ser Val Lys Ala Tyr Phe Ala
100 105 110

Leu Lys Leu Ala Gly Asp Asp Pro Glu Ala Ala His Met Arg Arg Ala
115 120 125

Arg Lys Ala Val Leu Glu Arg Gly Gly Ala Val Asn Ala Asn Val Phe
130 135 140

Thr His Ile Ala Leu Ala Leu Phe Gly Glu Ile Pro Trp Arg Gly Val
145 150 155 160

Pro Phe Met Pro Pro Glu Ile Leu Leu Leu Pro Arg Trp Phe Pro Phe
165 170 175

His Leu Ser Lys Val Ser Tyr Trp Ser Arg Thr Val Met Val Pro Leu
180 185 190

Phe Ile Leu Ala Ala His Lys Pro Arg Ala Arg Asn Pro Arg Ala Ile
195 200 205

His Ile Ser Glu Leu Phe Val Thr Asp Pro Gln Leu Glu Thr Gly Tyr
210 215 220

Phe Lys Ala Arg Ser Arg Leu Asn Arg Leu Phe Ile Thr Leu Asp Ala
225 230 235 240

Leu Gly Arg Arg Ile Glu Pro Phe Ile Pro Arg Ala Val Arg Ala Lys
245 250 255

Ala Leu Arg Arg Ala Ala Glu Trp Phe Ile Thr Arg Leu Asn Gly Glu
260 265 270

His Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn Ser Tyr Glu Ala
275 280 285

Leu Glu Leu Leu Gly Tyr Ala Ala Asp His Pro Leu Arg Gln Gln Val
290 295 300

Arg Lys Gly Leu Arg Asp Leu Val Val Glu Gln Ala Asp Arg Ala Tyr
305 310 315 320

Cys Gln Pro Cys Leu Ser Pro Ile Trp Asp Thr Ala Leu Ala Cys Leu
325 330 335

Ala Leu Gln Glu Ala Asp Arg Gly Ser Ser Ser Ala Gln Val Arg His
340 345 350

Ala Leu Asp Trp Leu Gln Ala Arg Gln Leu Leu Asp Thr Pro Gly Asp
355 360 365

Trp Ser Glu Gln His Pro Ser Leu Pro Gly Gly Gly Trp Pro Phe Gln
370 375 380

Phe Arg Asn Asp His Tyr Pro Asp Leu Asp Asp Thr Ala Ile Val Ala
385 390 395 400

Trp Ala Met Gln Arg Ala Ser Asp Pro Glu Arg Tyr Gly Ala Ala Ile
405 410 415

Arg Arg Ala Thr Val Trp Leu Leu Gly Met Gln Ser Ala Asn Gly Gly
420 425 430

Phe Ala Ala Phe Asp Ser Asp Asn Thr Arg Tyr Tyr Leu Asn Glu Ile
435 440 445

Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ser Asp Val
450 455 460

Thr Ala Arg Val Val Ala Leu Leu Gly Ser Leu Asp Gly Glu Val His
465 470 475 480

Asp Arg Ser Ala Leu Asn Arg Ala Val Ala Phe Leu His Arg Glu Gln
485 490 495

Glu Ala Glu Gly Cys Trp Tyr Gly Arg Trp Gly Thr Asn Tyr Ile Tyr
500 505 510

Gly Thr Trp Ser Val Leu Thr Ala Leu Glu Gln Leu Gly Tyr Asp Phe
515 520 525

Asn Ala Pro Trp Val Arg Lys Ala Val Ile Trp Leu Lys Ser Val Gln
530 535 540

Arg Asp Asp Gly Gly Trp Gly Glu Ser Asn Asp Thr Tyr Leu Asp His
545 550 555 560

Arg Pro Gln Asp Arg Gln Ala Asp Glu Ser Thr Pro Phe Gln Thr Ala
565 570 575

Trp Ala Val Leu Ala Leu Ile Ala Ala Gly Glu Cys Arg Ser Pro Glu
580 585 590

Val Trp Arg Gly Val Glu Tyr Leu Leu Arg His Gln Arg Pro Asp Gly
595 600 605

Leu Trp Tyr Cys Pro Trp Phe Thr Ala Pro Gly Phe Pro Arg Val Phe
610 615 620

Tyr Leu Lys Tyr His Gly Tyr Asp Ala Tyr Phe Pro Leu Met Ala Leu
625 630 635 640

Ala Arg Tyr Arg Asn Cys Val Leu Asp Asn Asp Ala
645 650


<210> 180
<211> 659
<212> PRT
<213> Nitrosococcus oceani

<400> 180
Met Thr Arg Ala Leu Arg Gln Ala Pro Glu Ser Ala Gly Ala Ile Gly
1 5 10 15

Ile Ala Ala Ala Ser Pro Ala Thr Glu Thr Ser Gly Gln Asp Thr His
20 25 30

Pro Arg Glu Ile Ser Gly Ala Ile Thr Ala Ala Arg Asp Ala Leu Leu
35 40 45

Lys Leu Gln Gln Ala Asp Gly His Trp Cys Phe Met Leu Glu Ala Asp
50 55 60

Cys Thr Ile Pro Ala Glu Tyr Ile Leu Trp Thr His Phe Thr Gly Glu
65 70 75 80

Leu Glu Pro Glu Ile Glu Arg Lys Leu Ala Ala Arg Leu Arg Ala Lys
85 90 95

Gln Ala Ser His Gly Gly Trp Pro Leu Tyr Glu Gly Gly Asp Leu Asp
100 105 110

Ile Ser Cys Ser Val Lys Val Tyr Tyr Ala Leu Lys Leu Val Gly Asp
115 120 125

Asp Pro Asn Ala Pro His Met Arg Arg Ala Arg Glu Ala Ile Leu Ala
130 135 140

Gln Gly Gly Gly Ala Arg Ala Asn Val Phe Thr Arg Leu Ala Leu Ala
145 150 155 160

Met Phe Ser Gln Ile Pro Trp Arg Gly Val Pro Phe Ile Pro Val Glu
165 170 175

Ile Met Leu Leu Pro Arg Trp Phe Pro Phe His Leu Ser Lys Val Ser
180 185 190

Tyr Trp Ser Arg Thr Val Met Val Pro Leu Ala Ile Leu Tyr Ser Leu
195 200 205

Lys Ala Gln Ala Gln Asn Pro Arg Asn Val His Ile Gln Glu Leu Phe
210 215 220

Thr Val Pro Pro Glu Gln Glu Arg His Tyr Phe Pro Val Arg Ser Arg
225 230 235 240

Leu Asn Lys Ile Leu Leu Ser Val Glu Arg Thr Ala Arg Leu Leu Glu
245 250 255

Pro Leu Ile Pro Ser Met Leu Arg Arg Arg Ala Leu Lys Lys Ala Glu
260 265 270

Thr Trp Phe Thr Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Gly Ile
275 280 285

Phe Pro Ala Met Val Asn Ala His Glu Ser Leu Ile Leu Leu Gly Tyr
290 295 300

Ser Pro Asp His Pro Trp Arg Val Gln Ala Lys Lys Ala Leu Gln Asn
305 310 315 320

Leu Val Ile Glu Glu Lys Asn Ser Ala Ser Cys Gln Pro Cys Leu Ser
325 330 335

Pro Ile Trp Asp Thr Gly Leu Ala Ala Leu Ala Leu Gln Glu Thr Glu
340 345 350

Gly Gly His Thr Thr Ala Pro Val Ile Arg Ala Leu Asp Trp Leu Lys
355 360 365

Glu Arg Gln Ile Leu Glu Gln Ser Gly Asp Trp Gln Val Gln His Pro
370 375 380

Asn Leu Lys Gly Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ser Tyr Tyr
385 390 395 400

Pro Asp Leu Asp Asp Thr Ala Leu Val Ala Trp Ser Met Asp Gln Ala
405 410 415

Ala Thr Pro Glu Arg Tyr Gly Glu Ala Ile Gly Arg Ala Cys Asp Trp
420 425 430

Leu Cys Gly Met Gln Ser Arg Asn Gly Gly Phe Ala Ala Phe Glu Ser
435 440 445

Asp Asn Thr His Tyr Tyr Leu Asn Glu Ile Pro Phe Ala Asp His Gly
450 455 460

Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Cys Ile Val
465 470 475 480

Leu Leu Gly Arg Leu Asn Lys Pro Gln Tyr Ala Glu Thr Leu Gln Arg
485 490 495

Ala Leu Asp Tyr Leu Arg Arg Glu Gln Glu Pro Asn Gly Ser Trp Phe
500 505 510

Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Ala Leu Thr
515 520 525

Ala Leu Glu Gln Ala Asn Ile Asp Pro Gln Glu Gly Phe Ile Arg Lys
530 535 540

Ala Val Glu Trp Leu Lys Gln Val Gln Arg Leu Asp Gly Gly Trp Gly
545 550 555 560

Glu Asp Asn Tyr Ser Tyr Phe Asp Ser Ser Leu Ala Gly Arg Tyr Gln
565 570 575

Glu Ser Thr Pro Val His Thr Ala Trp Ala Leu Leu Ala Leu Met Ala
580 585 590

Val Gly Glu Ala Asn Ser Glu Ala Val Lys Lys Gly Ile Ala Tyr Leu
595 600 605

Leu Gln Ile Gln Gln Glu Asp Gly Leu Trp Asp His Pro Ala Phe Asn
610 615 620

Ala Pro Gly Phe Pro Arg Val Phe Tyr Leu Lys Tyr His Gly Tyr Asp
625 630 635 640

Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn His Leu Asn
645 650 655

Arg Gln Cys


<210> 181
<211> 666
<212> PRT
<213> Nitrosomonas europaea

<400> 181
Met Ser Ile Ser Pro Thr Phe Ser Gly Ser Ser Leu Gln Lys Ser Ser
1 5 10 15

Leu Ser Asp His Ser Thr Ile Ser Glu Pro Phe Thr Val Val Asp Arg
20 25 30

Val Asn Gly Ile Ser Ala Val Ala Leu Asp Asp Ala Ile Thr Arg Ala
35 40 45

Arg Ser Ala Leu Leu Ala Gln Gln Arg Glu Asp Gly His Trp Cys Phe
50 55 60

Ser Leu Glu Ala Asp Cys Thr Ile Pro Ala Glu Tyr Ile Leu Met Met
65 70 75 80

His Phe Met Asp Glu Ile Asp Thr Ala Leu Glu Arg Arg Ile Ala Asn
85 90 95

Phe Leu Arg Asn Arg Gln Val Thr Asp Gly His Gly Gly Trp Pro Leu
100 105 110

Tyr Tyr Gly Gly Asp Phe Asp Met Ser Cys Ser Val Lys Val Tyr Tyr
115 120 125

Ala Leu Lys Leu Ala Gly Asp Ser Pro Glu Ala Ala His Met Val Arg
130 135 140

Ala Arg Asn Ala Ile Leu Glu Arg Gly Gly Ala Ala Arg Ser Asn Val
145 150 155 160

Phe Thr Arg Leu Leu Leu Ala Met Tyr Arg Gln Ile Pro Trp Arg Gly
165 170 175

Val Pro Phe Val Pro Ala Glu Ile Met Leu Leu Pro Arg Trp Phe Pro
180 185 190

Phe His Leu Ser Lys Val Ala Tyr Trp Ser Arg Thr Val Met Val Pro
195 200 205

Leu Ser Ile Leu Cys Thr Leu Lys Ala Lys Ala Ala Asn Pro Arg Asn
210 215 220

Ile His Val Arg Glu Leu Phe Thr Val Asp Pro Glu Met Glu Lys Asn
225 230 235 240

Tyr Phe Pro Val Arg Thr Pro Leu Asn His Leu Leu Leu Tyr Leu Glu
245 250 255

Arg Leu Gly Ser Lys Leu Glu Pro Leu Ile Pro Ser Phe Ile Arg Arg
260 265 270

Arg Ala Leu Lys Lys Ala Glu Gln Trp Thr Ile Glu Arg Leu Asn Gly
275 280 285

Arg Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Val Asn Ala Tyr Glu
290 295 300

Ala Leu Thr Leu Leu Gly Tyr Asp His Asp His Pro Leu Leu Gln Gln
305 310 315 320

Cys Arg Leu Ala Leu Arg Glu Leu Leu Val Asn Glu Gly Glu Asp Ile
325 330 335

Thr Trp Cys Gln Pro Cys Val Ser Pro Val Trp Asp Thr Val Leu Ala
340 345 350

Ser Leu Ala Leu Gln Glu Asp Glu Arg Ala Asp Asn Gly Pro Val Arg
355 360 365

His Ala Leu Asp Trp Leu Val Pro Leu Gln Ala Leu Asp Gln Pro Gly
370 375 380

Asp Trp Arg Asn Ser Arg Pro Asp Leu Pro Gly Gly Gly Trp Ala Phe
385 390 395 400

Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr Ala Ala Ala
405 410 415

Ala Trp Ala Leu Cys Gln Ala Asp Thr Glu Asp Tyr Arg Thr Ser Ile
420 425 430

Thr Arg Ala Ala Asp Trp Leu Ala Gly Met Gln Ser Ser Asn Gly Gly
435 440 445

Phe Ala Ala Phe Asp Ile Asp Asn Val His Tyr Tyr Leu Asn Glu Ile
450 455 460

Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Ser Ser Asp Val
465 470 475 480

Thr Ala Arg Cys Ile Gly Leu Leu Ala Leu Asn Gly Glu Ala Arg His
485 490 495

Gln Glu Thr Val Lys Arg Gly Leu Thr Phe Leu Phe Asn Glu Gln Glu
500 505 510

Pro Ser Gly Ala Trp Phe Gly Arg Trp Gly Thr Asn Tyr Val Tyr Gly
515 520 525

Thr Trp Ser Val Leu Glu Ala Leu Lys Leu Ala Arg Val Asp His Asp
530 535 540

His Gln Ala Val Lys Arg Ala Val Gln Trp Leu Lys Ser Val Gln Arg
545 550 555 560

Ala Asp Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Leu Asp Ser Glu
565 570 575

Leu Ala Gly Gln Leu Glu Thr Ser Thr Ser Phe Gln Thr Ala Trp Ala
580 585 590

Val Leu Gly Leu Met Ala Ala Gly Glu Val Gly Ser Thr Ala Val Arg
595 600 605

Asn Gly Ile Asp Tyr Leu Ile Arg Thr Gln Ser Ala Ala Gly Leu Trp
610 615 620

Glu Glu Pro Trp Phe Thr Ala Pro Gly Phe Pro Lys Val Phe Tyr Leu
625 630 635 640

Lys Tyr His Gly Tyr Ser Lys Tyr Phe Pro Leu Trp Ala Leu Asn Arg
645 650 655

Tyr Arg Ala Met Asn Ser Arg Ser Val Val
660 665


<210> 182
<211> 670
<212> PRT
<213> Nitrosomonas eutropha

<400> 182
Met Ser Ile Ser Gln Ala Phe Phe Arg Thr Leu Ile Gln Lys Ser Ser
1 5 10 15

Leu Ser Asp Ser Ser Leu Val Ser Glu Asn Phe Pro Ala Asp Asp Val
20 25 30

Ala Gly Asn Glu Ala Asn Glu Ile Ser Ala Val Thr Leu Asp Glu Ala
35 40 45

Ile Thr Arg Ala Tyr Thr Ala Leu Leu Ala Gln Gln Arg Glu Asp Gly
50 55 60

His Trp Cys Phe Pro Leu Glu Ala Asp Cys Thr Ile Pro Ala Glu Tyr
65 70 75 80

Ile Leu Met Met His Phe Met Asp Glu Val Asp Thr Val Leu Glu Arg
85 90 95

Lys Ile Ala Asn Phe Leu Arg Thr Arg Gln Val Thr Asp Gly His Gly
100 105 110

Gly Trp Pro Leu Tyr Tyr Gly Gly Asp Phe Asp Met Ser Cys Ser Val
115 120 125

Lys Thr Tyr Tyr Ala Leu Lys Leu Ala Gly Asp Ser Pro Glu Ala Ala
130 135 140

His Met Val His Ala Arg Asn Ala Ile Leu Glu Arg Gly Gly Ala Ala
145 150 155 160

Arg Ser Asn Val Phe Thr Arg Leu Leu Leu Ala Met Tyr Arg Gln Ile
165 170 175

Pro Trp Arg Gly Val Pro Phe Val Pro Ala Glu Ile Met Leu Leu Pro
180 185 190

Arg Trp Phe Pro Phe His Leu Ser Lys Val Ala Tyr Trp Ser Arg Thr
195 200 205

Val Met Val Pro Leu Ser Ile Leu Cys Thr Leu Lys Ala Lys Ala Ile
210 215 220

Asn Pro Arg Asn Val His Val Gln Glu Leu Phe Val Val Asp Pro Val
225 230 235 240

Lys Glu Lys Asn Tyr Phe Pro Val Arg Thr Ser Leu Asn Arg Leu Leu
245 250 255

Leu Tyr Val Glu Arg Leu Ala Ser Lys Leu Glu Pro Phe Ile Pro Ser
260 265 270

Phe Ile Arg Arg Arg Ala Val Lys Lys Ala Glu Gln Trp Val Ile Glu
275 280 285

Arg Leu Asn Gly Asn Asp Gly Leu Gly Ala Ile Phe Pro Ala Met Val
290 295 300

Asn Ala Tyr Glu Ala Leu Thr Leu Leu Gly His Asp Arg Asp His Pro
305 310 315 320

Leu Leu Gln Gln Cys Arg Gln Ser Leu Arg Glu Leu Leu Val Asp Glu
325 330 335

Gly Glu Glu Ile Thr Trp Cys Gln Pro Cys Val Ser Pro Val Trp Asp
340 345 350

Thr Val Leu Ala Thr Leu Ala Leu Gln Glu Asp Lys Gln Ala Asp Ser
355 360 365

Glu Pro Ile Arg Arg Ala Leu Asp Trp Ile Val Pro Leu Gln Ile Leu
370 375 380

Asp Glu Pro Gly Asp Trp Arg Asp Ser Arg Pro Asn Leu Leu Gly Gly
385 390 395 400

Gly Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp
405 410 415

Thr Ala Ala Val Ala Trp Ala Leu Ile Gln Thr Gly Ala Glu Asp Tyr
420 425 430

Arg Val Ser Ile Thr Arg Ala Ala Asp Trp Leu Ala Gly Met Gln Ser
435 440 445

Ser Asn Gly Gly Phe Ala Ala Phe Asp Ile Asp Asn Ala Tyr Tyr Tyr
450 455 460

Leu Asn Glu Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro
465 470 475 480

Thr Ser Asp Val Ser Ala Arg Cys Val Gly Leu Leu Ala Leu Asn Gly
485 490 495

Glu Val Arg His Gln Glu Ala Val Lys Arg Gly Leu Asp Phe Leu Phe
500 505 510

Asn Glu Gln Glu Ser Ser Gly Ala Trp Phe Gly Arg Trp Gly Ser Asn
515 520 525

Tyr Ile Tyr Gly Thr Trp Ser Val Leu Glu Ala Phe Arg Leu Ala Arg
530 535 540

Val Asp Lys Gly His Gln Ala Val Gln Arg Ala Ile Gln Trp Leu Glu
545 550 555 560

Ser Val Gln Arg Ala Asp Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr
565 570 575

Leu Asp Pro Gln Leu Ala Gly Gln Leu Glu Ala Ser Thr Ser Phe Gln
580 585 590

Thr Ala Trp Ala Val Leu Gly Leu Met Ala Ala Gly Glu Val Glu Asn
595 600 605

Thr Ala Val Arg Lys Gly Ile Asp Tyr Leu Leu Arg Thr Gln Ile Ala
610 615 620

Thr Gly Leu Trp Glu Glu Pro Trp Phe Thr Ala Pro Gly Phe Pro Arg
625 630 635 640

Val Phe Tyr Leu Lys Tyr His Gly Tyr Ser Lys Tyr Phe Pro Leu Trp
645 650 655

Ala Leu Asn Arg Tyr Arg Thr Leu Ser Ser Lys Ser Ala Val
660 665 670


<210> 183
<211> 665
<212> PRT
<213> Nitrosomonas sp. AL212

<400> 183
Met Asp Gly Ser Gln Arg Ile Ser Asp Met Ser Gln Gln Pro Glu Gly
1 5 10 15

Ile Ala Val Ser Asp Glu Ile Ser Ser Ala Tyr Ser Val Ser Ser Leu
20 25 30

Asn Gln Asp Glu Ile Asn Val Asp Glu Leu Glu Asn Lys Leu Thr Gln
35 40 45

Ala Arg Ser Ala Met Leu Ser Leu Gln Lys Pro Asp Gly His Trp Cys
50 55 60

Phe Pro Leu Glu Ala Asp Cys Thr Ile Pro Ala Glu Tyr Ile Leu Met
65 70 75 80

Met His Phe Met Asp Glu Ile Asp Val Ile Leu Glu Asn Lys Ile Ala
85 90 95

Arg Phe Ile Arg Glu Lys Gln Asp Leu Thr His Gly Gly Trp Pro Leu
100 105 110

Tyr Tyr Gly Gly Ala Phe Asp Ile Ser Cys Thr Ile Lys Ser Tyr Tyr
115 120 125

Ala Leu Lys Leu Val Gly Asp Ser Pro Asp Ala Ala His Met Val Arg
130 135 140

Ala Arg Glu Ala Ile Leu Glu Arg Gly Gly Ala Ala Lys Ala Asn Val
145 150 155 160

Phe Thr Arg Leu Leu Leu Ala Met Tyr Glu Gln Ile Pro Trp Ser Gly
165 170 175

Val Pro Val Val Pro Thr Glu Leu Met Leu Leu Pro Ser Trp Phe Pro
180 185 190

Phe His Ile Ser Lys Val Ser Tyr Trp Ser Arg Thr Val Met Ile Pro
195 200 205

Leu Ser Ile Leu Cys Thr Ile Lys Ala Arg Ala Ile Asn Pro Arg Asn
210 215 220

Val Asp Ile Arg Glu Leu Phe Ile Val Pro Pro Glu Gln Glu Lys Asn
225 230 235 240

Tyr Phe Pro Gln Ala Asp Thr Trp Leu Lys Arg Ala Phe Met Leu Val
245 250 255

Glu Arg Val Leu Ser Arg Val Glu Pro Lys Leu Pro Gln Ala Ile Arg
260 265 270

Gln Tyr Ser Ile Arg Lys Ala Glu Asn Trp Thr Leu Glu Arg Leu Asn
275 280 285

Gly Glu Cys Gly Ile Gly Ala Ile Phe Pro Ala Met Val Asn Ala His
290 295 300

Glu Ser Leu Ala Leu Leu Gly Tyr Ala Tyr Asp His Pro Ser Arg Val
305 310 315 320

Gln Cys Arg Asn Ala Leu Arg Gly Leu Leu Val Asp Glu Gly Glu Arg
325 330 335

Ala Trp Cys Gln Pro Cys Thr Ser Pro Val Trp Asp Thr Val Leu Thr
340 345 350

Cys Leu Ala Leu Gln Glu Asp Pro Ala Ala Asp Gln Gly Pro Val Leu
355 360 365

Lys Ala Leu Asp Trp Leu Val Asp Gln Gln Val Leu Asp Glu Pro Gly
370 375 380

Asp Trp Arg Asp Lys Arg Pro Asp Leu Leu Gly Gly Gly Trp Ala Phe
385 390 395 400

Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr Ala Ala Val
405 410 415

Ala Trp Ala Leu Asp Gln Ser Asp Ala Gln Arg Tyr Gln Lys Pro Leu
420 425 430

Asp Arg Ala Ala Asn Trp Leu Ala Gly Met Gln Ser Arg Asn Gly Gly
435 440 445

Phe Ala Ala Phe Asp Ile Asp Asn Thr Tyr His Tyr Leu Asn Glu Ile
450 455 460

Pro Phe Ala Asp His Gly Ala Leu Ile Asp Pro Pro Thr Ser Asp Val
465 470 475 480

Thr Ala Arg Cys Val Gly Leu Leu Gly Lys Tyr Gly Lys His Gln Arg
485 490 495

Glu Val Trp Arg Gly Ile Ser Phe Leu Leu Arg Glu Gln Glu Lys Asn
500 505 510

Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp
515 520 525

Ser Val Leu Glu Ala Phe Gln Leu Ala Asn Phe Asp Met Gln His Thr
530 535 540

Ser Val Arg Arg Ala Val Lys Trp Leu Glu Ser Val Gln Arg Val Asp
545 550 555 560

Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Leu Asp Ile Gln Leu Ala
565 570 575

Gly Gln Phe Pro Gln Thr Ser Thr Thr Phe Gln Thr Ala Trp Ala Val
580 585 590

Leu Gly Leu Met Ala Ala Gly Glu Val Asn Ser Lys Ser Val Arg Arg
595 600 605

Gly Ile Asn Tyr Leu Leu His Asn Gln Ala Asp Asp His Leu Trp Glu
610 615 620

Asp Pro Trp Phe Thr Ala Pro Gly Phe Pro Arg Val Phe Tyr Leu Arg
625 630 635 640

Tyr His Gly Tyr Ser Lys Phe Phe Pro Ile Trp Ala Leu Val Arg Tyr
645 650 655

Arg Ala Leu Thr Lys Glu Arg Val Ser
660 665


<210> 184
<211> 653
<212> PRT
<213> Nitrosospira multiformis

<400> 184
Met Lys Lys Phe Gly Gly Met Ala Arg Thr Ser Leu Gln Ala Gln Ser
1 5 10 15

Pro Gly Ser Asn Asn Thr Pro Ser Met Asp Glu Lys Met Leu Lys Ala
20 25 30

Gly Leu Glu Ala Ala Arg Gly Ala Leu Leu Ala Gln Gln Arg Glu Asp
35 40 45

Gly His Trp Cys Phe Pro Leu Glu Ala Asp Cys Thr Ile Pro Ala Glu
50 55 60

Tyr Ile Leu Met Met His Phe Met Asp Glu Val Asp Leu Asp Leu Glu
65 70 75 80

Val Arg Ile Ala Arg Phe Ile Arg Glu Lys Gln Asp Val Ala His Gly
85 90 95

Gly Trp Pro Leu Tyr Tyr Gly Gly Glu Phe Asp Leu Ser Cys Ser Val
100 105 110

Lys Ala Tyr Tyr Ala Leu Lys Ile Val Gly Asp Ser Pro Asp Ala Pro
115 120 125

His Met Val Arg Ala Arg Ala Ala Ile Leu Lys His Gly Gly Ala Ala
130 135 140

Arg Ala Asn Val Phe Thr Arg Leu Leu Leu Ala Met Tyr Asp Gln Leu
145 150 155 160

Pro Trp Arg Gly Val Pro Phe Val Pro Val Glu Ile Ile Leu Phe Pro
165 170 175

Lys Trp Phe Pro Phe His Thr Ser Lys Val Ala Tyr Trp Ser Arg Thr
180 185 190

Val Met Val Pro Leu Ser Ile Leu Cys Ser Leu Lys Ala Arg Ala Ala
195 200 205

Asn Pro Arg Lys Val Ala Ile Arg Glu Leu Phe Thr Val Pro Pro Gly
210 215 220

Glu Glu Arg Asn Tyr Phe Pro Val Arg Thr Ala Leu Asn Arg Val Phe
225 230 235 240

Leu Leu Ile Glu Arg Thr Leu Ser Leu Leu Glu Pro Phe Ile Pro Gln
245 250 255

Gly Val Arg Arg Leu Ala Leu Arg Arg Ala Glu Ser Trp Ile Val Glu
260 265 270

Arg Leu Asn Gly Asp Ser Gly Leu Gly Ala Ile Phe Pro Ala Met Val
275 280 285

Asn Ala Gly Glu Ala Leu Ala Leu Leu Gly Tyr Pro Tyr Asp His Pro
290 295 300

Ala Arg Glu Gln Cys Arg Lys Ala Leu Arg Leu Leu Leu Val Glu Glu
305 310 315 320

Gly Glu Arg Thr Trp Cys Gln Pro Cys Val Ser Pro Val Trp Asp Thr
325 330 335

Val Leu Thr Cys Leu Ala Phe Gln Glu Asp Thr Glu Val Asp Gln Lys
340 345 350

Pro Ile Arg Lys Ala Leu Asp Trp Leu Val Pro Cys Gln Val Leu Asp
355 360 365

Ala Pro Ala Asp Trp Gln Glu Asp His Pro Gly Leu Pro Gly Gly Gly
370 375 380

Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro Asp Leu Asp Asp Thr
385 390 395 400

Ala Ala Val Ala Trp Ala Leu Tyr Gln Ala Asp Pro Lys Ala Tyr Gln
405 410 415

Glu Ser Ile Ser Arg Ala Ala Asp Trp Leu Ala Gly Met Gln Ser Ser
420 425 430

Asn Gly Gly Phe Ala Ala Phe Asp Ser Asp Asn Thr Tyr Tyr Tyr Leu
435 440 445

Asn Glu Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr
450 455 460

Ser Asp Val Ser Ala Arg Cys Ala Gly Phe Leu Ala Leu Tyr Gly Gln
465 470 475 480

Ser Arg His Lys Gln Ala Leu Glu Arg Ser Leu Ala Tyr Leu Phe Asn
485 490 495

Glu Gln Glu Ala Ser Gly Ala Trp Phe Gly Arg Trp Gly Ser Asn Tyr
500 505 510

Ile Tyr Gly Thr Trp Ser Val Leu Glu Ala Phe Arg Leu Ala Gly Ile
515 520 525

Asp Ala Gly His Pro Ala Ile Arg Arg Ala Val His Trp Leu Lys Ser
530 535 540

Val Gln Arg Glu Asp Gly Gly Trp Gly Glu Ser Asn Asp Ser Tyr Leu
545 550 555 560

Ser Pro Gln Gln Ala Gly Gln Phe His Thr Ser Thr Ser Phe His Thr
565 570 575

Ala Trp Ala Leu Leu Ala Leu Met Gly Ala Gly Glu Trp Arg Ser His
580 585 590

Glu Val His Arg Gly Ile Ala Tyr Leu Leu Arg Glu Gln Asp Ser Asp
595 600 605

Gly Leu Trp His Glu Pro Trp Phe Thr Ala Pro Gly Phe Pro Arg Val
610 615 620

Phe Tyr Leu Lys Tyr Tyr Gly Tyr Thr Lys Tyr Phe Pro Val Trp Ala
625 630 635 640

Leu Thr Arg Phe His Ala Leu Asn Arg Lys Phe Pro Gly
645 650


<210> 185
<211> 638
<212> PRT
<213> Nostoc punctiforme

<400> 185
Met Gln Thr Gln Asp Arg Val Lys Val Asn Gln Val Ala Glu Ala Ile
1 5 10 15

Ala Ala Ser Gln Gln Tyr Leu Leu Ser Ile Gln Asn Pro Ala Gly Tyr
20 25 30

Trp Trp Ala Glu Leu Glu Ser Asn Val Thr Ile Thr Ala Glu Thr Val
35 40 45

Leu Leu His Lys Ile Trp Gly Thr Asp Gln Thr Arg Pro Leu His Lys
50 55 60

Val Glu Ala Tyr Leu Arg Gln Glu Gln Arg Gln His Gly Gly Trp Glu
65 70 75 80

Leu Phe Tyr Gly Asp Gly Gly Glu Leu Ser Thr Ser Val Glu Ala Tyr
85 90 95

Met Ala Leu Arg Leu Leu Gly Val Pro Ala Thr Asp Pro Ala Met Ile
100 105 110

Arg Ala Gln Ala Phe Ile Leu Gln Arg Gly Gly Ile Ser Lys Thr Arg
115 120 125

Ile Phe Thr Lys Leu His Leu Ala Leu Ile Gly Cys Tyr Asn Trp Arg
130 135 140

Gly Ile Pro Ser Leu Pro Pro Trp Ile Met Leu Leu Pro Lys Ala Phe
145 150 155 160

Pro Val Asn Ile Tyr Glu Met Ser Ser Trp Ala Arg Ser Ser Thr Val
165 170 175

Pro Leu Leu Val Val Cys Asp Arg Lys Pro Val Phe Ile Thr Asp Pro
180 185 190

Thr Ile Asn Leu Asp Glu Leu Tyr Ala Glu Gly Ile Asp Arg Val Arg
195 200 205

Trp Glu Leu Pro Gln Ser Gly Asp Trp Thr Asp Leu Phe Leu Thr Leu
210 215 220

Asp Gln Gly Phe Lys Trp Ala Glu Ser Leu Asn Leu Val Pro Phe Arg
225 230 235 240

Glu Glu Gly Ile Lys Ala Ala Glu Lys Trp Ile Leu Glu Arg Gln Glu
245 250 255

Ala Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn Ser Met
260 265 270

Leu Ala Leu Arg Cys Leu Asp Tyr Asp Arg Ser Asp Pro Ile Val Glu
275 280 285

Arg Gly Leu Gln Ala Ile Asp Asn Phe Ala Ile Glu Thr Asp Asn Ser
290 295 300

Tyr Arg Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Trp Val
305 310 315 320

Met Arg Ala Leu Val Glu Ser Gly Phe Val Pro Asp His Pro Ala Val
325 330 335

Val Lys Ala Gly Glu Trp Leu Leu Gln Lys Gln Ile Leu Asp Tyr Gly
340 345 350

Asp Trp Ala Val Lys Asn Arg Gln Gly Lys Pro Gly Ala Trp Ala Phe
355 360 365

Glu Phe Glu Asn Arg Phe Tyr Pro Asp Val Asp Asp Ser Ala Val Val
370 375 380

Val Met Ala Leu His Leu Ala Lys Leu Pro Asn Glu Lys Ile Lys Gln
385 390 395 400

Ala Ala Ile Ala Arg Ala Val Asn Trp Ile Ala Ser Met Gln Cys Lys
405 410 415

Pro Gly Gly Trp Ala Ala Phe Asp Leu Asp Asn Asp Gln Asp Trp Leu
420 425 430

Asn Ser Ile Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp Pro Asn Thr
435 440 445

Ala Asp Val Thr Ala Arg Val Val Glu Met Leu Gly Ala Cys Asp Leu
450 455 460

Ser Ile Asp Ser Asp Asn Leu Glu Arg Ser Leu Thr Tyr Leu Leu Arg
465 470 475 480

Glu Gln Glu Thr Glu Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr
485 490 495

Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala Leu Ala Leu Ile Asp Pro
500 505 510

Gln Arg His Lys Leu Ser Ile Glu Arg Gly Ala Ala Trp Leu Leu Gly
515 520 525

Cys Gln Asn Leu Asp Gly Gly Trp Gly Glu Thr Cys Arg Ser Tyr Asp
530 535 540

Asp Pro Ser Leu Lys Gly Lys Gly Asp Ser Thr Ala Ser Gln Thr Ala
545 550 555 560

Trp Ala Leu Ile Gly Leu Leu Ala Ala Gly Glu Ala Thr Gly Lys Leu
565 570 575

Ala Val Lys Ala Ile Glu Gln Gly Ile Gly Tyr Leu Met Ala Thr Gln
580 585 590

Gln Pro Asp Gly Thr Trp Phe Glu Ala Asn Phe Thr Gly Thr Gly Phe
595 600 605

Pro Cys Tyr Phe Tyr Leu Lys Tyr His Leu Tyr Gln Gln Tyr Phe Pro
610 615 620

Leu Ile Ala Leu Gly Arg Tyr Gln Ala Ala Ile Lys Glu Ser
625 630 635


<210> 186
<211> 637
<212> PRT
<213> Nostoc sp.

<400> 186
Met Arg Thr Gln Asp Arg Val Gln Val Asn Ser Ile Ala Glu Ala Ile
1 5 10 15

Ala Ala Ser Gln Lys Tyr Leu Leu Ser Leu Gln Asn Pro Ala Gly Tyr
20 25 30

Trp Trp Ala Glu Leu Glu Ser Asn Val Thr Ile Thr Ala Glu Val Val
35 40 45

Leu Leu His Lys Ile Trp Gly Thr Asp Lys Thr Arg Pro Leu His Lys
50 55 60

Val Glu Ala Tyr Leu Arg Ser Gln Gln Lys Gln His Gly Gly Trp Glu
65 70 75 80

Leu Phe Tyr Gly Asp Gly Gly Glu Leu Ser Thr Ser Val Glu Ala Tyr
85 90 95

Met Ala Leu Lys Leu Leu Gly Val Pro Ala Thr Asp Pro Ala Met Ile
100 105 110

Gln Ala Arg Asp Phe Ile Leu Gln Arg Gly Gly Ile Ser Lys Thr Arg
115 120 125

Ile Phe Thr Lys Phe His Leu Ala Leu Ile Gly Cys Tyr Asn Trp Arg
130 135 140

Gly Leu Pro Ser Leu Pro Ala Trp Val Met Leu Leu Pro Asn Gln Phe
145 150 155 160

Pro Val Asn Ile Tyr Glu Met Ser Ser Trp Ala Arg Ser Ser Thr Val
165 170 175

Pro Leu Leu Ile Val Phe Asp Gln Lys Pro Val Tyr Gln Val Asn Pro
180 185 190

Thr Ile Thr Leu Asp Glu Leu Tyr Ala Glu Gly Val Glu Asn Val Arg
195 200 205

Tyr Glu Leu Pro Arg Ser Gly Asp Trp Thr Asp Leu Phe Leu Thr Leu
210 215 220

Asp Glu Gly Phe Lys Leu Ala Glu Ser Phe Asn Phe Ile Pro Phe Arg
225 230 235 240

Glu Glu Gly Ile Lys Ala Ala Glu Lys Trp Ile Ile Glu Arg Gln Glu
245 250 255

Ala Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn Ser Met
260 265 270

Leu Ala Leu Arg Ser Leu Gly Tyr Asp Thr Asn Asp Pro Ile Val Glu
275 280 285

Arg Gly Leu Gln Ala Leu Asp Asn Phe Ala Ile Glu Thr Val Asp Cys
290 295 300

Tyr Arg Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala Trp Val
305 310 315 320

Ile Arg Ala Leu Ile Asp Ser Gly Ile Ala Pro Asp His Pro Ala Ile
325 330 335

Val Lys Ala Gly Glu Trp Leu Leu Gln Lys Gln Ile Leu Asp Tyr Gly
340 345 350

Asp Trp Asn Val Lys Asn Arg Gln Gly Lys Pro Gly Ala Trp Ala Phe
355 360 365

Glu Phe Glu Asn Arg Phe Tyr Pro Asp Val Asp Asp Thr Ala Val Val
370 375 380

Val Met Ala Leu His Ala Ala Lys Leu Pro Asn Glu Gln Leu Lys Gln
385 390 395 400

Lys Ala Cys Asp Arg Ala Leu Gln Trp Val Ala Ser Met Gln Cys Lys
405 410 415

Pro Gly Gly Trp Ala Ala Phe Asp Leu Asp Asn Asp Gln Asp Trp Leu
420 425 430

Asn Ser Val Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp Pro Asn Thr
435 440 445

Ala Asp Val Thr Ala Arg Val Ile Glu Met Leu Gly Ala Cys Asn Leu
450 455 460

Ser Ile Asp Ser His Asn Leu Glu Arg Ala Leu Thr Tyr Leu Leu Asn
465 470 475 480

Glu Gln Glu Ala Glu Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr
485 490 495

Ile Tyr Gly Thr Ser Gly Val Leu Ser Ala Leu Ala Leu Ile Asn Pro
500 505 510

Gln Lys Tyr Gln Arg His Ile Gln Gln Gly Ala Thr Trp Leu Val Gly
515 520 525

Cys Gln Asn Pro Asp Gly Gly Trp Gly Glu Thr Cys Phe Ser Tyr Asn
530 535 540

Asp Pro Ser Leu Lys Gly Gln Gly Asp Ser Thr Pro Ser Gln Thr Ala
545 550 555 560

Trp Ala Leu Ile Gly Leu Ile Ala Ala Gly Glu Ala Thr Gly Asn Phe
565 570 575

Ala His Asp Ala Ile Glu Arg Gly Ile Asn His Leu Val Ser Thr Gln
580 585 590

Gln Pro Asp Gly Ser Trp Phe Glu Ala Tyr Phe Thr Gly Thr Gly Phe
595 600 605

Pro Cys His Phe Tyr Leu Lys Tyr His Tyr Tyr Gln Gln Tyr Phe Pro
610 615 620

Leu Ile Ala Leu Gly Arg Tyr Gln Ala Ile Lys Ser Leu
625 630 635


<210> 187
<211> 654
<212> PRT
<213> Oligotropha carboxidovorans

<400> 187
Met Thr Ser Asp Thr Ala Ser Ala Ala Ala Leu Asp Pro Arg Arg Leu
1 5 10 15

Ala Thr Ser Ile Thr Arg Ala Ser Arg Ala Leu His Asp Val Gln Gln
20 25 30

Pro Asp Ser His Trp Val Phe Glu Leu Glu Ala Asp Val Thr Ile Pro
35 40 45

Ala Glu Tyr Val Met Met Arg His Tyr Phe Ala Glu Pro Val Asp Ala
50 55 60

Glu Ile Glu Ala Lys Ile Ala Lys Tyr Leu Arg Arg Met Gln Asn Asp
65 70 75 80

Asn Gly Gly Trp Ser Leu Phe Tyr Gly His Glu Phe Asp Met Ser Ala
85 90 95

Ser Val Lys Ala Tyr Tyr Ala Leu Lys Met Ile Gly Asp Ser Pro Asp
100 105 110

Ala Pro His Met Lys Lys Ala Arg Glu Ala Met Leu Ala Arg Gly Gly
115 120 125

Ala Ser Arg Ala Asn Val Phe Thr Arg Ile Met Leu Ala Leu Phe Gly
130 135 140

Gln Val Ser Trp Lys Ala Val Pro Met Met Pro Val Glu Ile Met Leu
145 150 155 160

Leu Pro Arg Trp Phe Pro Phe His Leu Thr Lys Val Ser Tyr Trp Ala
165 170 175

Arg Thr Val Ile Val Pro Leu Leu Val Leu Met Thr Leu Lys Pro Arg
180 185 190

Ala Lys Asn Pro Arg Gly Ile Gly Val Arg Glu Leu Phe Leu Glu Asp
195 200 205

Pro Gln Thr Val Gly Pro Thr Pro Lys Ala Ala His Gln Ser Gln Leu
210 215 220

Trp Phe Thr Ser Phe Asp Ile Ile Asp Arg Val Leu Arg Ile Thr Asp
225 230 235 240

Pro Phe Phe Pro Lys Gly Met Arg Lys Arg Ala Ile Ala Lys Ala Glu
245 250 255

Ala Phe Val Thr Glu Arg Leu Asn Gly Val Asp Gly Leu Gly Ala Ile
260 265 270

Phe Pro Ala Met Val Asn Ser Ile Met Met Tyr Asp Val Leu Gly Tyr
275 280 285

Pro Pro Asn Asp Pro Asn Arg Ala Leu Ala Arg Glu Ser Val Glu Arg
290 295 300

Leu Leu Val Ile Lys Asp Asp Glu Ala Tyr Cys Gln Pro Cys Val Ser
305 310 315 320

Pro Val Trp Asp Thr Ala Leu Ala Ala His Ser Met Leu Glu Ser Gly
325 330 335

Glu Ala Ala Asp Ile Glu Ala Ala Lys Ala Gly Leu Asp Trp Leu Leu
340 345 350

Pro Arg Gln Val Leu Asp Leu Lys Gly Asp Trp Ala Asp Lys Arg Pro
355 360 365

Asp Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala His Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Met Asp Arg Val
385 390 395 400

Arg Arg Leu Asp Gly Thr Thr Lys Tyr Asp Glu Ala Ile Ala Arg Ala
405 410 415

Thr Glu Trp Ile Leu Gly Leu Gln Ser Glu Asn Gly Gly Trp Ala Ala
420 425 430

Phe Asp Ala Asp Asn Leu Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ala
435 440 445

Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg
450 455 460

Cys Leu Ser Met Leu Ala Gln Leu Gly Asp Thr Leu Glu Thr Ser Glu
465 470 475 480

Pro Met Arg Arg Gly Val Glu Tyr Leu Arg Lys Thr Gln Leu Pro Asp
485 490 495

Gly Ser Trp Phe Gly Arg Trp Gly Ile Asn Tyr Val Tyr Gly Thr Trp
500 505 510

Ser Val Leu Cys Ala Leu Asn Ala Val Gly Val Pro His Asp Asp Pro
515 520 525

Met Ile Ala Lys Ala Ala Asp Trp Leu Glu Ser Ile Gln Asn Glu Asp
530 535 540

Gly Gly Trp Gly Glu Asp Gly Asn Ser Tyr Lys Leu Asn Tyr Lys Gly
545 550 555 560

Tyr Glu Arg Ala Ala Thr Thr Ala Ser Gln Thr Ala Trp Ala Thr Leu
565 570 575

Ala Leu Met Ala Ala Gly Arg Val Asp Arg Asp Ala Thr Gln Arg Gly
580 585 590

Ile Asp Asn Leu Val Gln Ser Gln Glu Ala Asp Gly Phe Trp Gly Glu
595 600 605

Pro Tyr Tyr Thr Gly Gly Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr
610 615 620

His Gly Tyr Ser Lys Phe Phe Pro Leu Trp Ala Met Ala Arg Tyr Arg
625 630 635 640

Asn Leu Arg Ser Ser Asn Ser Arg Phe Val Gly Ala Gly Met
645 650


<210> 188
<211> 609
<212> PRT
<213> Paenibacillus sp.

<400> 188
Met Arg Ser Glu Leu Leu Gln Leu Gln Ser Ala Asp Gly Ser Trp Arg
1 5 10 15

Leu Cys Phe Asp Ser Gly Thr Met Pro Asp Ser Tyr Phe Ile Ile Ile
20 25 30

Leu Arg Met Leu Gly Tyr Ser Gln Asp Glu Ala Leu Ile Arg Gln Ile
35 40 45

Ala Ser Arg Ile Leu Ser Arg Gln Leu Pro Asn Gly Thr Trp Lys Ile
50 55 60

Tyr Pro Asp Glu Glu Asp Gly Asn Leu Asp Ala Thr Ala Glu Ala Tyr
65 70 75 80

Phe Ala Leu Leu Tyr Ser Gly Phe Leu Thr Lys Leu Asp Pro Arg Met
85 90 95

Gln Leu Ala Lys Gln Phe Ile Leu Ser Lys Gly Gly Leu Ser Lys Ile
100 105 110

Arg Ser Leu Leu Thr Gln Ala Ile Phe Ala Ala Ala Gly Gln Ala Ser
115 120 125

Trp Pro Lys Ser Met Arg Ile Pro Leu Glu Val Phe Phe Ser Asp Asn
130 135 140

Gly Ile Gly Ile Asp Leu Phe Ser Leu Ser Gly His Ala Arg Val His
145 150 155 160

Ile Val Pro Ile Ile Met Leu Ala Asn Ala Gln Phe Val Gln His Ser
165 170 175

Ala Ser Met Pro Asp Leu Ser Asp Leu Phe Ala Gly Ser Ser Lys Arg
180 185 190

Phe Glu Asn Asp Ser Pro Trp Ile Ala Ala Leu Ala Thr Leu Ile Gly
195 200 205

Ser Leu Ser Leu Ser Glu Leu Leu Pro Phe Glu Ser Pro Thr Pro Gln
210 215 220

Glu Lys Ala Val Gln Phe Leu Phe Asp Arg Leu Glu Pro Asp Gly Thr
225 230 235 240

Leu Leu Thr Tyr Thr Thr Ala Thr Met Phe Met Ile Leu Val Leu Leu
245 250 255

Met Leu Gly Tyr Ser Ser Ser Ser Pro Leu Ile His Arg Met Val Ser
260 265 270

Gly Ile His Ser Val Ile Cys Ala Asn Ser His Val Gln Ile Ala Ser
275 280 285

Ser Glu Val Trp Asp Thr Ala Met Leu Val His Ala Leu Arg Lys Ala
290 295 300

Gly Val Asn Pro Thr Ser Thr Ala Leu Glu Asn Ala Gly Ala Tyr Leu
305 310 315 320

Arg Gln Arg Gln Gln Thr Gln Leu Gly Asp Trp Ala Ile Arg Asn Pro
325 330 335

Gly Thr Pro Ala Gly Gly Trp Gly Phe Ser Asn Val Asn Thr Leu Tyr
340 345 350

Pro Asp Val Asp Asp Thr Thr Ala Ala Leu Arg Ala Ile Gln Pro Tyr
355 360 365

Ser Ser Arg Thr Pro Glu Leu Gln Ala Asp Trp Gln Arg Gly Leu Asn
370 375 380

Trp Val Leu Thr Met Arg Asn Asp Asn Gly Gly Trp Pro Ala Phe Glu
385 390 395 400

Arg Gln Gly Ser Arg Leu Pro Ile Thr Phe Phe Asn Phe Glu Gly Ala
405 410 415

Lys Asp Ile Ala Val Asp Pro Ser Thr Val Asp Leu Thr Ser Arg Thr
420 425 430

Leu Gln Phe Leu Gly Gln Glu Leu Gly Met Asn Ala Gly Asn Ser Trp
435 440 445

Ile Glu Ser Thr Leu Arg Trp Val Leu Ser Gln Gln Glu Ser Asn Gly
450 455 460

Ser Trp Tyr Gly Arg Trp Gly Ile Thr Tyr Val His Gly Thr Ser Ala
465 470 475 480

Ala Leu Gln Gly Leu Thr Ala Val Gly Ile Ala Glu Asp His Pro Ala
485 490 495

Val Lys Lys Gly Val Asp Trp Leu Leu Gln Val Gln Asn Glu Asp Gly
500 505 510

Gly Trp Gly Glu Ser Cys Ile Ser Asp Lys Val Arg Arg Tyr Val Pro
515 520 525

Leu Asn Phe Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Gly Leu
530 535 540

Thr Ala Ala Leu Pro Lys Pro Thr Pro Ala Leu Glu Arg Gly Val Asp
545 550 555 560

Ala Leu Leu Gln Ser Leu Asp Arg His Asp Trp Thr Tyr Thr Tyr Pro
565 570 575

Thr Gly Gly Ala Leu Pro Gly Ser Val Tyr Ala His Tyr Ala Ser Asn
580 585 590

Asn Tyr Ile Trp Pro Leu Leu Ala Leu Ser Asn Ile Trp Gln Lys Tyr
595 600 605

Ser


<210> 189
<211> 609
<212> PRT
<213> Paenibacillus sp. JDR-2

<400> 189
Met Arg Ser Glu Leu Leu Gln Leu Gln Ser Ala Asp Gly Ser Trp Arg
1 5 10 15

Leu Cys Phe Asp Ser Gly Thr Met Pro Asp Ser Tyr Phe Ile Ile Ile
20 25 30

Leu Arg Met Leu Gly Tyr Ser Gln Asp Glu Ala Leu Ile Arg Gln Ile
35 40 45

Ala Ser Arg Ile Leu Ser Arg Gln Leu Pro Asn Gly Thr Trp Lys Ile
50 55 60

Tyr Pro Asp Glu Glu Asp Gly Asn Leu Asp Ala Thr Ala Glu Ala Tyr
65 70 75 80

Phe Ala Leu Leu Tyr Ser Gly Phe Leu Thr Lys Leu Asp Pro Arg Met
85 90 95

Gln Leu Ala Lys Gln Phe Ile Leu Ser Lys Gly Gly Leu Ser Lys Ile
100 105 110

Arg Ser Leu Leu Thr Gln Ala Ile Phe Ala Ala Ala Gly Gln Ala Ser
115 120 125

Trp Pro Lys Ser Met Arg Ile Pro Leu Glu Val Phe Phe Ser Asp Asn
130 135 140

Gly Ile Gly Ile Asp Leu Phe Ser Leu Ser Gly His Ala Arg Val His
145 150 155 160

Ile Val Pro Ile Ile Met Leu Ala Asn Ala Gln Phe Val Gln His Ser
165 170 175

Ala Ser Met Pro Asp Leu Ser Asp Leu Phe Ala Gly Ser Ser Lys Arg
180 185 190

Phe Glu Asn Asp Ser Pro Trp Ile Ala Ala Leu Ala Thr Leu Ile Gly
195 200 205

Ser Leu Ser Leu Ser Glu Leu Leu Pro Phe Glu Ser Pro Thr Pro Gln
210 215 220

Glu Lys Ala Val Gln Phe Leu Phe Asp Arg Leu Glu Pro Asp Gly Thr
225 230 235 240

Leu Leu Thr Tyr Thr Thr Ala Thr Met Phe Met Ile Leu Val Leu Leu
245 250 255

Met Leu Gly Tyr Ser Ser Ser Ser Pro Leu Ile His Arg Met Val Ser
260 265 270

Gly Ile His Ser Val Ile Cys Ala Asn Ser His Val Gln Ile Ala Ser
275 280 285

Ser Glu Val Trp Asp Thr Ala Met Leu Val His Ala Leu Arg Lys Ala
290 295 300

Gly Val Asn Pro Thr Ser Thr Ala Leu Glu Asn Ala Gly Ala Tyr Leu
305 310 315 320

Arg Gln Arg Gln Gln Thr Gln Leu Gly Asp Trp Ala Ile Arg Asn Pro
325 330 335

Gly Thr Pro Ala Gly Gly Trp Gly Phe Ser Asn Val Asn Thr Leu Tyr
340 345 350

Pro Asp Val Asp Asp Thr Thr Ala Ala Leu Arg Ala Ile Gln Pro Tyr
355 360 365

Ser Ser Arg Thr Pro Glu Leu Gln Ala Asp Trp Gln Arg Gly Leu Asn
370 375 380

Trp Val Leu Thr Met Arg Asn Asp Asn Gly Gly Trp Pro Ala Phe Glu
385 390 395 400

Arg Gln Gly Ser Arg Leu Pro Ile Thr Phe Phe Asn Phe Glu Gly Ala
405 410 415

Lys Asp Ile Ala Val Asp Pro Ser Thr Val Asp Leu Thr Ser Arg Thr
420 425 430

Leu Gln Phe Leu Gly Gln Glu Leu Gly Met Asn Ala Gly Asn Ser Trp
435 440 445

Ile Glu Ser Thr Leu Arg Trp Val Leu Ser Gln Gln Glu Ser Asn Gly
450 455 460

Ser Trp Tyr Gly Arg Trp Gly Ile Thr Tyr Val His Gly Thr Ser Ala
465 470 475 480

Ala Leu Gln Gly Leu Thr Ala Val Gly Ile Ala Glu Asp His Pro Ala
485 490 495

Val Lys Lys Gly Val Asp Trp Leu Leu Gln Val Gln Asn Glu Asp Gly
500 505 510

Gly Trp Gly Glu Ser Cys Ile Ser Asp Lys Val Arg Arg Tyr Val Pro
515 520 525

Leu Asn Phe Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Gly Leu
530 535 540

Thr Ala Ala Leu Pro Lys Pro Thr Pro Ala Leu Glu Arg Gly Val Asp
545 550 555 560

Ala Leu Leu Gln Ser Leu Asp Arg His Asp Trp Thr Tyr Thr Tyr Pro
565 570 575

Thr Gly Gly Ala Leu Pro Gly Ser Val Tyr Ala His Tyr Ala Ser Asn
580 585 590

Asn Tyr Ile Trp Pro Leu Leu Ala Leu Ser Asn Ile Trp Gln Lys Tyr
595 600 605

Ser


<210> 190
<211> 642
<212> PRT
<213> Paenibacillus sp. oral taxon 786

<400> 190
Met Ala Leu Ser Asn Gly Glu Ile Arg Glu Glu Ile Gln Arg Leu Ser
1 5 10 15

Glu Glu Leu Ile Gln Arg Gln Glu Pro Asp Gly Ser Trp Arg Phe Cys
20 25 30

Phe Glu Asn Gly Ile Thr Ile Asp Ala Cys Thr Ile Ile Leu Leu Arg
35 40 45

Thr Leu Asn Val Asp Lys Glu Glu Leu Ile Arg Gln Leu His Asp Arg
50 55 60

Ile Val Ala Ala Gln Gln Pro Glu Gly Cys Trp Arg Trp Tyr His Asp
65 70 75 80

Asp Lys Glu Gly His Leu Ser Ala Thr Val Glu Ala Tyr Tyr Ala Leu
85 90 95

Leu Cys Ser Gly Tyr Ser Arg Pro Glu Asp Glu Pro Ile Gln Arg Ala
100 105 110

Lys Arg Tyr Ile Leu Asp Arg Gly Gly Ile Gly Gln Ala Arg Ser Leu
115 120 125

Phe Thr Lys Ala Ile Leu Ala Ala Thr Gly Gln Arg Lys Trp Pro Ala
130 135 140

Ser Leu Ser Leu Ile Pro Ile Glu Ile Leu Leu Leu Pro Glu Ser Leu
145 150 155 160

Pro Leu Asn Phe Tyr Asp Phe Ser Gly Tyr Ser Arg Val His Leu Val
165 170 175

Pro Leu Leu Ile Met Ala Glu Arg Asn Phe Arg Thr Arg Ser Val Arg
180 185 190

Thr Pro Asp Leu Ser Glu Leu Phe Leu Asp Ala Arg Asn Gly Glu Glu
195 200 205

Asp Pro Leu Thr Leu Thr Pro Glu Ser Arg Glu Pro Leu Lys Leu Ile
210 215 220

Gln Ser Gly Leu Ala His Leu Val Gly Thr Pro Arg Arg Ile Arg Gln
225 230 235 240

Ala Ala Val Asn Arg Ala Glu Gln Tyr Met Leu Asp Arg Ile Glu Gly
245 250 255

Asp Gly Thr Leu Tyr Thr Tyr Ala Ser Cys Thr Val Leu Met Val Phe
260 265 270

Ala Leu Leu Ala Leu Gly Tyr Glu Pro Gln His Pro Val Ile Gln Arg
275 280 285

Ala Val Glu Gly Leu Ser Gln Met Lys Phe Thr Val Asp Ser Thr Gly
290 295 300

Gln Gly Gly Thr Arg Tyr Val Thr Ile Gln Asn Ser Pro Ser Thr Val
305 310 315 320

Trp Asp Thr Ala Leu Ile Ser Tyr Ala Leu Gln Glu Ala Gly Val Ser
325 330 335

Ser Ser His Pro Ala Ile Gln Arg Ala Ala Asp Tyr Leu Arg Asn Arg
340 345 350

Gln His Arg Arg Pro Gly Asp Trp Gln Ile His Asn Pro Gly Ile Val
355 360 365

Pro Gly Gly Trp Gly Phe Ser Glu Thr Asn Thr Phe Val Pro Asp Val
370 375 380

Asp Asp Thr Thr Ala Ala Leu Arg Ala Leu Ser Ala Leu His Gly Ser
385 390 395 400

Glu Pro Ala Val Leu Gly Ala Trp Asn Arg Gly Leu Asn Trp Val Trp
405 410 415

Ser Met Gln Asn Asn Asp Gly Gly Trp Pro Ala Phe Glu Lys Asn Thr
420 425 430

Asn Lys Glu Met Leu Thr Trp Leu Ala Ile Glu Gly Ala Lys Ser Ala
435 440 445

Ala Thr Asp Pro Ser Glu Ala Asp Leu Thr Gly Arg Thr Leu Glu Tyr
450 455 460

Leu Gly Asn Phe Ala Lys Leu Ser Val Arg Gln Asp Trp Val Ala Arg
465 470 475 480

Gly Ala Asp Trp Leu Leu Ser His Gln Glu Ala Asp Gly Ser Trp Tyr
485 490 495

Gly Arg Trp Gly Ile Cys Tyr Ile Tyr Gly Thr Trp Ala Ala Leu Thr
500 505 510

Gly Leu Met Ala Val Gly Met Pro Ala Asp His Pro Gly Ile Ala Lys
515 520 525

Ala Ala Asn Trp Leu Ile Arg Ile Gln Asn Ala Asp Gly Gly Trp Gly
530 535 540

Glu Ser Cys Arg Ser Asp Gln Val Arg Arg Tyr Val Pro Leu His Ala
545 550 555 560

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Asp Ala Leu Ile Ala Val
565 570 575

His Asp Arg Arg Ala Pro Glu Ile Glu Arg Gly Val Ala Arg Leu Ile
580 585 590

Ala Leu Leu His Glu Asp Asp Trp Pro Ser Thr Tyr Pro Thr Gly Ala
595 600 605

Gly Leu Pro Gly Tyr Phe Tyr Val His Tyr His Ser Tyr Arg Tyr Ile
610 615 620

Trp Pro Leu Leu Ala Leu Ser His Tyr Val Asn Lys Tyr Gly Asp Ser
625 630 635 640

Ser Pro


<210> 191
<211> 603
<212> PRT
<213> Paramecium tetraurelia

<400> 191
Met Ile Lys Lys Ile Leu Val Leu Ile Leu Leu Met Val Val Val Thr
1 5 10 15

Ser Lys Val Asp Ile Glu Arg Val Gln Thr Val Ile Arg Asp Ala Arg
20 25 30

Glu Ile Cys Trp Asn Glu Leu Thr Asp Asn Glu Trp Val Tyr Pro Thr
35 40 45

Tyr Leu Gly Thr Leu Phe Leu Ser Glu Tyr Tyr Phe Glu Leu Lys Ala
50 55 60

Leu Gly Ile Gln Asn Ser Gln Phe Glu Glu Ser Lys Phe Thr Gln Ile
65 70 75 80

Leu Leu Gly Ser Gln Leu Pro Asp Gly Ser Trp Val Gln Val Glu Asp
85 90 95

Ala Tyr Ile Gln Thr Gly Gln Leu Asp Ala Thr Ile Phe Asn Tyr Trp
100 105 110

Tyr Leu Lys Ala Val Gly Ile Asp Ile His Thr Asp Thr Met Lys Lys
115 120 125

Ala Gln Glu Trp Ile Lys Ala Asn Gly Gly Ile Glu Lys Ala Gln Thr
130 135 140

Met Thr Lys Phe Lys Leu Ala Met Phe Gly Gln Tyr Pro Trp Lys Lys
145 150 155 160

Leu Phe Lys Ile Pro Leu Ile Leu Phe Tyr Lys Lys Phe Asn Pro Leu
165 170 175

Tyr Ile Lys Asp Ile Thr Ala Gln Trp Val Tyr Pro His Met Thr Ala
180 185 190

Leu Ala Tyr Leu Gln Asn Gln Arg Ile Ile Phe Asn Val Ala Val Ser
195 200 205

Ile Ser Glu Leu Tyr Lys Asn Lys Ala Pro Lys Ile Lys Asn His Gln
210 215 220

Lys Lys Gly Arg Pro Ser Phe Phe Ile Asn Asn Leu Val Gln Glu Met
225 230 235 240

Leu Lys Leu Arg Gln Pro Met Gly Ser Phe Gly Gly Tyr Thr Val Ser
245 250 255

Thr Leu Leu Ser Met Leu Ala Leu Asn Asp Tyr Thr Gly Arg Thr Asn
260 265 270

Lys His Lys Ser Glu Ile Ser Asp Ala Leu Lys Lys Gly Leu Asp Phe
275 280 285

Val Glu Phe Asn Tyr Phe Asn Phe Arg Gln Ala Tyr His Gly Ser Leu
290 295 300

Asp Asp Gly Arg Trp Trp Asp Thr Ile Leu Ile Ser Trp Ala Met Leu
305 310 315 320

Glu Ser Gly Glu Asp Lys Glu Lys Val Arg Pro Ile Val Glu Asn Met
325 330 335

Leu Gln Lys Gly Val Gln Pro Asn Gly Gly Ile Glu Tyr Gly Tyr Asp
340 345 350

Phe Gly Tyr Ala Pro Asp Ala Asp Asp Thr Gly Leu Leu Leu Gln Val
355 360 365

Leu Ser Tyr Tyr Gly Thr Asp Tyr Ala Asp Ala Met Asp Lys Gly Ala
370 375 380

Glu Phe Val Tyr Ser Val Gln Asn Thr Asp Gly Gly Phe Pro Ala Phe
385 390 395 400

Asp Lys Gly Lys Met Gly Lys Asn Pro Leu Tyr Lys Tyr Ala Phe Lys
405 410 415

Ile Ala Gly Ile Ala Asp Ser Ala Glu Ile Phe Asp Pro Ser Ser Pro
420 425 430

Asp Val Thr Ala His Ile Leu Glu Gly Leu Ile Ser Ser Asp Arg Ser
435 440 445

Asn Tyr Asp Val Val Val Lys Ser Leu Lys Tyr Phe Met Asp Thr Gln
450 455 460

Glu Asn Phe Gly Ser Trp Glu Gly Arg Trp Gly Ile Asn Tyr Ile Tyr
465 470 475 480

Ala Ala Gly Ala Val Leu Pro Ala Leu Lys Lys Met Asn Asn Gly Trp
485 490 495

Ala Lys Ala Val Asn Trp Leu Val Ser Lys Gln Asn Ala Asp Gly Gly
500 505 510

Phe Gly Glu Thr Thr Leu Ser Tyr Arg Asp Pro Lys Lys Tyr Asn Gly
515 520 525

Ile Gly Val Ser Thr Val Thr Gln Thr Ser Trp Gly Leu Leu Gly Leu
530 535 540

Leu Ala Val Glu Asp His Tyr Asp Val Lys Glu Ala Ile Glu Lys Ala
545 550 555 560

Arg Asp Gly Glu Phe Lys Asp Ile Ser Val Val Gly Thr Gly His Arg
565 570 575

Gly Leu Leu Tyr Leu Gln Tyr Pro Ser Tyr Ala Arg Ser Phe Pro Val
580 585 590

Ile Ser Leu Gly Arg Phe Leu Asp Gln Gln Arg
595 600


<210> 192
<211> 737
<212> PRT
<213> Pelobacter carbinolicus

<400> 192
Met Asp Lys Ile Lys Met Lys Asn Ile Asn Gln Pro Lys Phe Arg Val
1 5 10 15

Phe Arg Gly Gly Gln Lys Ala Ala Thr Pro Cys Pro Gly Thr Thr Asn
20 25 30

Glu Arg Arg Gly Ala Leu Asp Arg Gly Arg Leu Ser Ala Ser Leu Lys
35 40 45

His Ser Arg Glu Trp Leu Leu Ser Leu Gln Ala Asp Ala Gly Asn Trp
50 55 60

Val Phe Ala Leu Glu Ala Asp Thr Thr Ile Ala Ser Glu Tyr Val Met
65 70 75 80

Leu Gln Arg Phe Leu Gly Arg Pro Leu Ala Pro Glu Leu Gln Gln Arg
85 90 95

Leu Ala Asn Tyr Leu Leu Ser Arg Gln Leu Pro Asp Gly Gly Trp Pro
100 105 110

Leu Tyr Ala Glu Asp Gly Phe Ala Asn Ile Ser Thr Thr Val Lys Ala
115 120 125

Tyr Leu Ala Leu Lys Leu Leu Gly Tyr Pro Thr His Cys Asp Pro Leu
130 135 140

Val Arg Ala Arg Gln Ile Val Leu Ala Leu Gly Gly Ala Glu Lys Cys
145 150 155 160

Asn Val Phe Thr Arg Ile Ala Leu Ala Leu Phe Gly Gln Ile Pro Trp
165 170 175

Arg Thr Thr Pro Ala Met Pro Val Glu Ile Met Leu Leu Pro Arg Trp
180 185 190

Phe Tyr Phe His Leu Ser Lys Ile Ser Tyr Trp Ala Arg Thr Val Val
195 200 205

Val Pro Leu Leu Ile Leu Tyr Ala Lys Arg Pro Val Cys Arg Leu Glu
210 215 220

Pro Trp Glu Gly Ile Pro Glu Leu Phe Val Thr Pro Pro Asp Lys Leu
225 230 235 240

Gly Tyr Leu Asp Val Cys Lys Pro Gly Gln Trp Arg Lys Asn Val Phe
245 250 255

Ile Trp Val Asp Arg Leu Thr Arg Lys Met Val Arg Cys Val Pro Arg
260 265 270

Arg Leu His Asn Leu Ala Leu Arg Ala Ala Glu Thr Trp Thr Arg Glu
275 280 285

His Met Gln Gly Ala Gly Gly Ile Gly Ala Ile Phe Pro Ala Met Ala
290 295 300

Asn Ala Val Met Ala Leu Arg Thr Leu Gly Cys Ser Pro Asp Asp Ala
305 310 315 320

Asp Tyr Gln Arg Gly Leu Lys Ala Leu Asp Asp Leu Leu Ile Asp Arg
325 330 335

Cys Asp Val Pro Pro Arg Glu Asp Thr Pro Val Ser Pro Cys Trp Cys
340 345 350

Thr Gly Thr Ser Ala Ala Pro Met Leu Asp Pro Ser Pro Ala Gly Ser
355 360 365

His Ala Gln Gly Gly Asp Gln Gly Ile Cys Gln Pro Cys Ala Ser Pro
370 375 380

Ile Trp Asp Thr Gly Leu Ala Leu Thr Ala Leu Leu Glu Gly Gly Leu
385 390 395 400

Asp Ala Arg His Pro Ala Val Asp Arg Ala Val Arg Trp Leu Leu Asp
405 410 415

Gln Gln Val Asp Val Lys Gly Asp Trp Ala Gln Arg Val Pro Asn Leu
420 425 430

Glu Ala Gly Gly Trp Ala Phe Gln Phe Glu Asn Ala Leu Tyr Pro Asp
435 440 445

Leu Asp Asp Thr Ser Lys Val Leu Met Ser Leu Ile Arg Ala Gly Ala
450 455 460

Met Asp Asn Pro Gly Tyr Arg Gln Glu Leu Ser Arg Ala Ile Asn Trp
465 470 475 480

Val Ile Gly Met Gln Asn Ser Asp Gly Gly Trp Gly Ala Phe Asp Val
485 490 495

Asp Asn Asn Tyr Leu Tyr Leu Asn Asp Ile Pro Phe Ala Asp His Gly
500 505 510

Ala Leu Leu Asp Pro Ser Thr Ala Asp Val Thr Gly Arg Cys Ile Glu
515 520 525

Met Leu Ala Met Ala Gly Phe Gly Arg Asp Phe Leu Pro Ile Ala Arg
530 535 540

Gly Val Asp Phe Leu Arg Arg Glu Gln Glu Asp Phe Gly Gly Trp Tyr
545 550 555 560

Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Ala Leu Ser
565 570 575

Gly Leu Ile His Ala Gly Glu Asp Leu Gln Ala Pro Tyr Ile Arg Gln
580 585 590

Ala Val Gly Trp Leu Glu Ser Val Gln Asn Pro Asp Gly Gly Trp Gly
595 600 605

Glu Thr Cys Tyr Ser Tyr Asp Asp Pro Ala Leu Ala Gly Arg Gly Val
610 615 620

Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala
625 630 635 640

Gly Glu Val Asp Asn Leu Ala Val Arg Arg Gly Ile Gln Tyr Leu Val
645 650 655

Glu Glu Gln Asn Arg Ala Gly Gly Trp Asp Glu Arg His Phe Thr Gly
660 665 670

Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Ser Gln
675 680 685

Tyr Phe Pro Leu Trp Ala Leu Gly Leu Tyr Glu Arg Leu Ser Ser Gly
690 695 700

Asn Pro Ser Arg Gln Gln Met Val Arg Arg Ala Gly Pro Ala Gly Leu
705 710 715 720

His Leu Pro Val Leu Asp Arg Arg Lys Lys Leu Arg Arg Lys Arg Lys
725 730 735

Ala


<210> 193
<211> 695
<212> PRT
<213> Pelobacter carbinolicus

<400> 193
Met Asn Val Ile Arg Gln Leu Asn Ser Gly Val Asn Ala Ala Lys Ser
1 5 10 15

Leu Asp Asp Gly Ile Glu Ser Ala Ile Glu Trp Leu Ala Glu Asn Gln
20 25 30

Asp Lys Glu Gly Phe Trp Val Gly Met Leu Glu Ser Asn Ser Cys Ile
35 40 45

Glu Ala Glu Trp Ile Leu Ala Met His Leu Leu Gly Val Lys Asp Asp
50 55 60

Pro Lys Tyr Asp Lys Val Val Gln Ala Ile Leu Asn Glu Gln Arg Glu
65 70 75 80

Asp Gly Ser Trp Ala Val Tyr Tyr Asp Ala Pro Ala Gly Asp Ile Asn
85 90 95

Ala Thr Val Glu Ala Tyr Ala Ala Leu Arg Thr Ala Gly Phe Gly Ala
100 105 110

Gly Asp Glu Arg Leu Ile Lys Ala Arg Asn Trp Ile Phe Ser His Gly
115 120 125

Gly Leu Lys Asn Val Arg Val Phe Thr Arg Tyr Trp Leu Ala Leu Ile
130 135 140

Gly Glu Trp Pro Trp Asp Glu Thr Pro Ala Leu Ala Pro Glu Ile Ile
145 150 155 160

Tyr Leu Pro Ala Trp Cys Pro Leu Asn Ile Tyr Asp Phe Ala Cys Trp
165 170 175

Ala Arg Ala Thr Leu Val Pro Leu Ser Val Leu Ser Val Arg Arg Pro
180 185 190

Val Lys Pro Leu Pro Ala Glu Ser Arg Leu Asp Glu Leu Phe Pro Glu
195 200 205

Gly Arg Glu Asn Ala Asp Tyr Ser Leu Pro Glu Ser Glu Lys Gly Leu
210 215 220

Ala Glu Arg Phe Phe Leu Val Val Asp Trp Phe Leu Lys Lys Tyr Asn
225 230 235 240

Arg Leu Pro Met Gln Phe Gly Arg Glu Lys Ala Ile Arg Leu Cys Leu
245 250 255

Glu Trp Ile Val Arg His Gln Asp Tyr Asp Gly Gly Trp Gly Gly Ile
260 265 270

Gln Pro Pro Leu Ile Tyr Ser Leu Ile Ala Leu Asn Thr Glu Gly Tyr
275 280 285

Gly Ile Asn His Pro Val Ile Ser Lys Gly Leu Asp Ala Phe Asn Pro
290 295 300

Pro Trp Ala Tyr Glu Lys Asn Gly Gly Val Tyr Leu Gln Cys Ser Glu
305 310 315 320

Ser Pro Val Trp Asp Thr Leu Phe Thr Met Leu Ala Leu Phe Glu Ser
325 330 335

Gly Cys Ser Phe Asp Asp Thr Pro Met Met Arg Pro Ala Leu Asp Trp
340 345 350

Ile Leu Ser Lys Gln Ile Thr Ser Trp Gly Asp Trp Gln Val Lys Val
355 360 365

Arg Gly Val Arg Pro Gly Gly Trp Ala Phe Glu Arg Ala Asn Thr Ala
370 375 380

Tyr Pro Asp Val Asp Asp Thr Ala Leu Ala Leu Val Val Leu Ala Glu
385 390 395 400

Ala Arg Arg His Val Lys Asp Ser Ala Ala Val Asp Ala Ala Leu Glu
405 410 415

Arg Ala Glu Glu Trp Ile Leu Gly Leu Gln Cys Arg Asn Gly Gly Trp
420 425 430

Ala Ala Phe Asp Arg Asp Asn Asn Ser Ala Ile Val Thr Lys Ile Pro
435 440 445

Phe Cys Asp Phe Gly Glu Val Leu Asp Pro Pro Ser Val Asp Val Thr
450 455 460

Ala His Val Val Glu Ala Leu Ala Ala Leu Gly Arg Asp Arg His Asp
465 470 475 480

Pro Val Val Ala Arg Ala Leu Lys Tyr Ile Arg Ser Glu Gln Glu Pro
485 490 495

Gly Gly Ser Trp Phe Gly Arg Trp Gly Val Asn His Ile Tyr Gly Thr
500 505 510

Cys Ala Val Leu Pro Ala Leu Ala Ala Ile Gly Glu Asp Met Arg Ala
515 520 525

Pro Tyr Val Leu Arg Ala Ala Asp Trp Leu Val Arg His Gln Asn Asp
530 535 540

Asp Gly Gly Trp Gly Glu Ser Cys Ala Ser Tyr Met Asp Asp Ser Gln
545 550 555 560

Cys Gly Gln Gly Ser Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Met
565 570 575

Ala Leu Val Ala Met Ser Ser His Asp Tyr Asp Glu Ala Ile Arg Arg
580 585 590

Gly Leu Asp Tyr Leu Leu Ser His Gln Lys Ser Gly Thr Trp Asp Glu
595 600 605

Pro Gln Tyr Thr Gly Thr Gly Phe Pro Gly Tyr Gly Val Gly Glu Arg
610 615 620

Thr Asn Leu Lys Glu Ala Gly Ala Thr Leu Asp Gln Gly Cys Glu Leu
625 630 635 640

Ala Arg Gly Phe Met Ile Asn Tyr Asn Met Tyr Arg His Tyr Phe Pro
645 650 655

Leu Ile Ala Met Ala Arg Ala Arg Arg His Leu Gly Leu Ala Ala Asn
660 665 670

Pro Arg His Gln Asp Ser Arg Ser Ser Val Glu Val Ala Pro Glu Ala
675 680 685

Leu Arg Gly Arg Ala Cys Gly
690 695


<210> 194
<211> 719
<212> PRT
<213> Pelobacter propionicus

<400> 194
Met Lys Lys Ala Thr Arg Ser Val Phe Ser Leu Leu Asp Gly Gly Lys
1 5 10 15

Ile Ser Asp Ser Gly Ser Arg Gly Asp Ser Arg His Ala Gly Ser Arg
20 25 30

Leu Asp Ser Val Thr Lys Ser Ala Ala Ala Leu Leu Ala Ser Arg Gln
35 40 45

Asn Pro Asp Gly His Trp Val Phe Asp Leu Glu Ala Asp Val Thr Ile
50 55 60

Pro Ala Glu Tyr Val Met Met Arg Cys Phe Ile Gly Glu Pro Leu Asp
65 70 75 80

Ser Asp Met Ala Ser Arg Leu Ser Ala Tyr Leu Leu Glu Arg Gln Leu
85 90 95

Pro Asp Gly Gly Trp Pro Leu Tyr Ala Val Asp Gly Asn Ala Asn Ile
100 105 110

Ser Ala Thr Val Lys Ala Tyr Phe Ala Leu Lys Leu Leu Gly His Asp
115 120 125

Lys Tyr Ala Pro His Met Val Ser Ala Arg Arg Met Ile Leu Ala Gln
130 135 140

Gly Gly Ala Glu Arg Ser Asn Val Phe Thr Arg Ile Thr Leu Ala Leu
145 150 155 160

Phe Gly Gln Val Pro Trp His Thr Thr Pro Ala Met Pro Ile Glu Ile
165 170 175

Met Leu Leu Pro Lys Trp Phe Phe Phe His Leu Ser Lys Val Ala Tyr
180 185 190

Trp Ser Arg Thr Val Ile Val Pro Leu Leu Ile Leu Tyr Asn Lys Gln
195 200 205

Pro Val Cys Arg Leu Gly Tyr Ser Glu Gly Ile Ala Glu Leu Phe Ser
210 215 220

Thr Ser Pro Asp Met Leu Val His Leu Asp His Phe Arg Tyr Arg Ala
225 230 235 240

Trp Arg Lys Asn Ala Phe Ile Val Leu Asp Arg Leu Leu Lys Arg Thr
245 250 255

Met His Leu Val Pro Gly Arg Ile Lys Arg Arg Ala Leu Glu Glu Ala
260 265 270

Glu Arg Trp Thr Arg Glu Arg Met Lys Gly Asp Gly Ser Ile Gly Ala
275 280 285

Ile Tyr Pro Ala Met Ala Asn Ala Val Met Ala Leu Lys Thr Leu Gly
290 295 300

Cys Gly Asp Ser Asp Pro Asp Tyr Leu Arg Gly Leu Arg Ala Ile Asp
305 310 315 320

Arg Leu Leu Ile His Gly Lys Pro Glu Ala Gly Ala Leu Pro Ala Asp
325 330 335

Gly Ala Gly Thr Leu Phe Pro Val Leu Asp Gly Ala Ser Ser Ala Ala
340 345 350

Val Asp Leu Tyr Pro Ala Ser Leu Ser Asp Thr Ala Lys Ser His Ala
355 360 365

Phe Ser Phe Cys Gln Pro Cys Asn Ser Pro Val Trp Asp Thr Ala Leu
370 375 380

Ser Leu Thr Ala Leu Ser Glu Ala Gly Gly Gly Gly Tyr Ser Pro Glu
385 390 395 400

Arg Ala Met Glu Trp Leu Phe Asn Arg Gln Ile Ala Thr Gln Gly Asp
405 410 415

Trp Thr Glu Arg Cys Pro Gly Leu Glu Cys Gly Gly Trp Ala Phe Gln
420 425 430

Tyr Glu Asn Ala Leu Tyr Pro Asp Val Asp Asp Thr Ala Lys Val Leu
435 440 445

Met Ser Leu Phe Arg Ala Gly Ala Leu Glu Arg Gly Glu Tyr Pro Glu
450 455 460

Lys Ile Ala Lys Ala Val Arg Trp Val Leu Gly Met Gln Gly Ala Asp
465 470 475 480

Gly Gly Trp Gly Ala Phe Asp Val Asp Asn Asn His Phe Tyr Leu Asn
485 490 495

Asp Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Ser Thr Ala
500 505 510

Asp Leu Thr Gly Arg Cys Ile Glu Met Leu Gly Met Leu Gly His Gly
515 520 525

Pro Asp Tyr Pro Pro Ile Thr Arg Gly Ile Glu Phe Leu Arg Glu Glu
530 535 540

Gln Glu Pro Phe Gly Gly Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile
545 550 555 560

Tyr Gly Thr Trp Ser Val Leu Ser Gly Leu Ser Gln Ala Gly Glu Asp
565 570 575

Met Gly Arg Pro Tyr Val Arg Lys Ala Val Glu Trp Leu Val Ser Cys
580 585 590

Gln Asn Asp Asp Gly Gly Trp Gly Glu Thr Cys Ala Ser Tyr Asp Asp
595 600 605

Pro Ser Leu Ala Gly Ser Gly Ala Ser Thr Ala Ser Gln Thr Ala Trp
610 615 620

Ala Leu Leu Gly Leu Met Ala Ala Gly Glu Ala Asp His Ala Ala Val
625 630 635 640

Arg Ala Gly Ile Ala Tyr Leu Ala Asp Ser Phe Ala Asp Gly Trp Asp
645 650 655

Glu Arg His Phe Thr Gly Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg
660 665 670

Tyr His Gly Tyr Ser Leu Phe Phe Pro Val Trp Ala Leu Gly Val Tyr
675 680 685

Ala Arg His Arg Glu Gly Gly Lys Thr Val Gln Glu Gln Val Arg Glu
690 695 700

Arg Gly Val Asn Gly Val Phe Asp Phe Val Met Gly Gly Ser Ala
705 710 715


<210> 195
<211> 679
<212> PRT
<213> Pelobacter propionicus

<400> 195
Met Asn Pro Ala Lys Tyr Lys Ile Ser Ser Ser Leu Thr Ser Leu Asn
1 5 10 15

Ala Glu Pro Val Glu Gln Ala Pro Leu Pro Ala Lys Arg Thr Gly Ser
20 25 30

Lys Val His Arg Leu Pro Pro Ser Ile Trp Lys Lys Met Val Ala Glu
35 40 45

Ala Lys Ser Pro Leu Asp Lys Gly Ile Glu Arg Thr Arg Asp Phe Phe
50 55 60

Leu Arg Glu Gln Leu Pro Asp Gly Tyr Trp Trp Ala Glu Leu Glu Ser
65 70 75 80

Asn Val Thr Ile Ser Ala Glu Tyr Val Met Leu Phe His Phe Leu Gly
85 90 95

Met Val Asp Arg Glu Arg Glu Arg Lys Leu Ala Asn Tyr Ile Leu Ala
100 105 110

Lys Gln Thr Ser Glu Gly Phe Trp Ser Leu Trp His Asn Gly Pro Gly
115 120 125

Asp Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys Leu Ala Gly
130 135 140

Tyr Ser Ala Asp His Pro Ala Met Ala Lys Ala Arg Ala Phe Val Leu
145 150 155 160

Ala Asn Gly Gly Ile Ile Lys Ala Arg Val Phe Thr Lys Ile Phe Leu
165 170 175

Ala Leu Phe Gly Glu Phe Ala Trp Phe Gly Val Pro Ser Met Pro Ile
180 185 190

Glu Leu Met Leu Leu Pro Asp Trp Ala Tyr Phe Asn Met Tyr Glu Phe
195 200 205

Ser Ser Trp Ser Arg Ala Thr Ile Ile Pro Leu Ser Val Val Met Ser
210 215 220

Glu Arg Pro Val Arg Lys Leu Pro Pro Arg Ala Gln Val Gln Glu Leu
225 230 235 240

Phe Val Arg Pro Pro Arg Pro Thr Asp Tyr Thr Ile Thr Arg Glu Asp
245 250 255

Gly Leu Phe Thr Trp Lys Asn Phe Phe Ile Gly Ala Asp His Leu Ile
260 265 270

Lys Val Tyr Glu Ser Ser Pro Ile Arg Pro Phe Lys Lys Arg Ala Val
275 280 285

Ala Leu Ala Glu Asn Trp Ile Leu Glu His Gln Glu Gln Ser Gly Asp
290 295 300

Trp Gly Gly Ile Gln Pro Ala Met Leu Asn Ser Ile Leu Ala Leu His
305 310 315 320

Cys Leu Gly Tyr Ala Asn Asp His Pro Ala Val Ala Lys Gly Leu Asp
325 330 335

Ala Leu Ala Asn Phe Cys Ile Glu Asp Asp Asp Cys Ile Val Leu Gln
340 345 350

Ser Cys Val Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Val Ala Leu
355 360 365

Gln Glu Ala Asp Val Pro Ala Asp His Pro Ala Leu Val Lys Ala Ala
370 375 380

Gln Trp Leu Leu Asn Leu Glu Val Arg Arg Lys Gly Asp Trp Gln Val
385 390 395 400

Lys Cys Pro Glu Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu Asn
405 410 415

Asp Trp Tyr Pro Asp Val Asp Asp Ser Gly Phe Val Met Leu Ser Ile
420 425 430

Lys Asn Ile Lys Val Arg Asp Arg Lys His Arg Glu Glu Ala Ile Lys
435 440 445

Arg Gly Ile Ala Trp Cys Leu Gly Met Gln Ser Glu Asn Gly Gly Trp
450 455 460

Gly Ala Phe Asp Arg Asn Asn Thr Lys Tyr Leu Leu Asn Lys Ile Pro
465 470 475 480

Phe Ala Asp Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr
485 490 495

Gly Arg Met Leu Glu Leu Met Gly Asn Phe Asp Tyr Pro Lys Ser His
500 505 510

Pro Ala Ala Glu Arg Ala Leu Ala Phe Leu Lys Lys Glu Gln Glu Ser
515 520 525

Glu Gly Pro Trp Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr
530 535 540

Trp Ser Val Leu Cys Gly Leu Glu Ala Ile Gly Glu Asp Met Asn Gln
545 550 555 560

Pro Tyr Ile Arg Lys Ala Val Asn Trp Ile Lys Ser Arg Gln Asn Asn
565 570 575

Asp Gly Gly Trp Gly Glu Val Cys Glu Ser Tyr Phe Asp Arg Ser Leu
580 585 590

Met Gly Ser Gly Pro Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Leu
595 600 605

Ala Leu Met Ala Ala Gly Glu Ala Asn Ser Arg Ala Ala Ala Gln Gly
610 615 620

Val Lys Tyr Leu Leu Glu Thr Gln Asn Glu Asp Gly Thr Trp Asp Glu
625 630 635 640

Asp Ala Phe Thr Gly Thr Gly Phe Pro Lys Phe Phe Met Ile Lys Tyr
645 650 655

His Ile Tyr Arg Asn Cys Phe Pro Leu Thr Ala Leu Gly Arg Tyr Arg
660 665 670

Arg Leu Thr Ala Ala Lys Gly
675


<210> 196
<211> 669
<212> PRT
<213> Penicillium chrysogenum

<400> 196
Met Ser Met Thr Ser Arg Glu Asp His Asp Ala Ser Ser Leu Ile Ser
1 5 10 15

Gln Val Glu His Ala Leu Lys Leu Ser Asn Asp Tyr Ala Leu Gly Leu
20 25 30

Val His Pro Asp Gly His Trp Tyr Gly Glu Met Asn Thr Asn Val Thr
35 40 45

Val Thr Ala Glu Tyr Val Phe Leu Arg Gln Ala Leu Arg Leu Asp Leu
50 55 60

Lys Thr Asp Ile Ala Ala Tyr Cys His Tyr Leu Leu Ser Gln Gln Asn
65 70 75 80

Ser Asp Gly Ser Trp Gly Leu Ala Pro Glu Tyr Pro Gly Asp Val Ser
85 90 95

Thr Ser Thr Glu Ala Tyr Leu Ala Leu Lys Ile Leu Gly Thr Ser Pro
100 105 110

His Thr Pro Ala Met Arg Asn Ala Arg Ala Phe Val Leu Lys Ala Gly
115 120 125

Gly Ile Ala Arg Val Arg Ile Phe Thr Arg Ile Phe Leu Ala Thr Phe
130 135 140

Gly Leu Phe Pro Trp Ser Ala Val Pro Glu Leu Pro Val Glu Leu Met
145 150 155 160

Leu Leu Pro Ser Ile Cys Pro Ile Asn Ile Tyr Lys Phe Ala Ser Trp
165 170 175

Ala Arg Gly Thr Ile Ala Pro Leu Leu Ile Ile Cys His His Gln Pro
180 185 190

Val Tyr Ser Leu Pro Asn Gly Lys Ser Thr Asp Asn Asp Tyr Leu Asp
195 200 205

Glu Leu Trp Val Asp Cys Thr Asn Lys Ser Val Pro Tyr Gly Leu Pro
210 215 220

Leu Trp Asp Leu Met Ser Gln Gly Glu Phe Ala Gly Leu Ala Phe Gly
225 230 235 240

Val Leu Asp Lys Val Leu Tyr Gln Leu Asn Gly Leu Arg Ser Ile Pro
245 250 255

Leu Ile Arg Ala Tyr Ala Arg Lys Gln Cys Ile Gln Trp Ile Leu Glu
260 265 270

Arg Gln Glu Lys Thr Gly Asp Trp Ala Gly Ile Phe Pro Pro Met His
275 280 285

Ala Asn Met Tyr Ala Phe Thr Leu Glu Gly Tyr Lys Leu Asp Asp Asp
290 295 300

Pro Val Arg Leu Gly Phe Gln Ala Leu Glu Arg Phe Ala Trp Glu Asp
305 310 315 320

Glu Lys Gly Lys Arg Ile Gln Ala Cys Val Ser Pro Val Trp Asp Thr
325 330 335

Ala Leu Met Thr Ile Gly Leu Cys Asp Ala Met Ser Pro Asn Lys Gln
340 345 350

Thr Ile Asp His Ala Leu Ala Trp Ile Arg Ala Arg Gln Leu Leu Glu
355 360 365

Pro Arg Gly Asp Trp Arg Val Tyr Arg Pro Gln Leu Ala Pro Gly Gly
370 375 380

Phe Ser Phe Glu Tyr Glu Asn Ser Trp Tyr Pro Asp Val Asp Asp Thr
385 390 395 400

Ala Ala Ile Ile Leu Ala Gln Val Lys His Asp Asn Gly Ser Ile Gly
405 410 415

Ser Asn Ser Val Ile Ala Ala Ala Thr Trp Ile Leu Gly Met Gln Asn
420 425 430

Pro Asp Gly Gly Trp Ala Ala Phe Asp Val Glu Asn Asp Lys Leu Phe
435 440 445

Leu Asn Lys Ile Pro Phe Ser Asp Met Asp Ser Leu Cys Asp Thr Ser
450 455 460

Cys Ala Asp Ile Thr Gly Arg Ile Leu Glu Ala Tyr Gly Leu Met Met
465 470 475 480

Met Lys Tyr Phe Ser Ala Lys Ser Asp Ala Asp Pro Leu Leu His Thr
485 490 495

Leu Arg Ala Ala Cys Met Arg Gly Met His Tyr Leu Ala Ser Thr Gln
500 505 510

Glu Pro Asn Gly Ser Trp Tyr Gly Arg Trp Gly Cys Asn Tyr Ile Tyr
515 520 525

Gly Thr Ser His Val Leu Cys Gly Leu Ala Tyr Phe Val Glu Lys Arg
530 535 540

Leu Val Cys Val Met Val Lys Ser Ala Leu Gln Trp Leu Lys Ser Arg
545 550 555 560

Gln Asn Asp Asp Gly Gly Trp Gly Glu Ser Leu Leu Ser Tyr Gln Ser
565 570 575

Pro Asp Arg Glu Gln Gln Ala Ser Thr Pro Ser Gln Thr Ala Trp Ala
580 585 590

Leu Met Gly Leu Leu Ser His Leu Pro Val Thr Asp Asp Ala Ile Glu
595 600 605

Arg Gly Ile Arg Tyr Leu Val Ser Ser Gln Arg Pro Glu Lys Gly Ile
610 615 620

Gly Ser Ser Trp Pro Gln Ala Glu Tyr Thr Gly Thr Gly Phe Pro Asn
625 630 635 640

His Phe Tyr Leu Gly Tyr Asp Tyr Tyr Arg His Tyr Phe Pro Met Met
645 650 655

Ala Leu Gly Arg Tyr Leu Gln Gly Ser Arg Gly Leu Asn
660 665


<210> 197
<211> 705
<212> PRT
<213> Planctomyces limnophilus

<400> 197
Met Thr Ser Gly Thr Phe Gly Ala Lys Arg Val Asp Leu Leu Ala Ala
1 5 10 15

Phe Glu His Ser Ala Pro Ala Glu Lys Thr Arg Glu Thr Cys Val Gly
20 25 30

Leu Gln Thr Ala Ile Ala Arg Thr Arg Gln Tyr Leu Leu Asp Gln Gln
35 40 45

His Ser Glu Gly Phe Phe Val Ala Glu Leu Glu Gly Asp Thr Ile Leu
50 55 60

Glu Ser Glu Tyr Ile Leu Leu Leu Ala Phe Leu Asn Glu Gly Gln Ser
65 70 75 80

Pro Asp Ala Gln Ala Ala Ala Arg Tyr Leu Leu Thr Lys Gln Asn Thr
85 90 95

Asp Gly Ser Trp Ser Asn Phe Pro Gly Gly Pro Ile Asp Val Ser Cys
100 105 110

Ala Val Lys Ala Tyr Leu Ala Leu Arg Ile Thr Gly His Ala Ala Asp
115 120 125

Glu Pro Ala Leu Ile Arg Ala Arg Glu Ala Ile Leu Gln Ala Gly Gly
130 135 140

Val Glu Arg Val Asn Ser Phe Thr Arg Phe Tyr Leu Ala Met Leu Gly
145 150 155 160

Leu Ile Pro Tyr Ser Leu Cys Pro Ala Val Pro Pro Glu Val Val Leu
165 170 175

Leu Pro Asp Trp Phe Pro Ile Asn Leu Ser Gln Met Ser Ala Trp Ser
180 185 190

Arg Thr Ile Val Val Pro Leu Ser Leu Leu Trp Ala Phe Gln Pro Ala
195 200 205

Val Glu Leu Asn Asp Ala Asp Gly His Gln Ile Thr Ile Glu Glu Leu
210 215 220

Tyr Ala Ser Pro Glu Lys Gln Leu Pro Arg Phe Ile Arg Gly Val Asn
225 230 235 240

His Glu Ser Asn Ser Asn Gly Trp Met Asn Trp Ser Arg Phe Phe Phe
245 250 255

Arg Val Asp Gln Cys Leu Lys Ser Ile Glu Ser Tyr Gly Ile Lys Pro
260 265 270

Leu Arg Ser Arg Ala Val Arg Lys Cys Val Gln Trp Ile Leu Asp Arg
275 280 285

Gln Glu Met Ser Asp Gly Leu Gly Ala Ile Phe Pro Pro Ile Val Trp
290 295 300

Thr Leu Ile Gly Leu Lys Cys Ala Gly Phe Asp Asp Gln His Pro Met
305 310 315 320

Val Gln Lys Gln Arg Asp Glu Leu Asn Arg Leu Met Leu Arg Glu Gln
325 330 335

Asp Ala Leu Arg Leu Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala
340 345 350

Ile Ser Ile Ile Ala Leu Arg Glu Ser Gly Val Glu Pro Asp His Pro
355 360 365

Ala Leu Ser Lys Ala Arg Asn Trp Leu Leu Ser Lys Glu Val Arg His
370 375 380

Ala Gly Asp Trp Ser Lys Ala His Pro Glu Thr Pro Val Ser Gly Trp
385 390 395 400

Tyr Phe Glu Phe Asn Asn Glu Phe Tyr Pro Asp Val Asp Asp Thr Ala
405 410 415

Met Val Leu Ile Ala Leu Ala Ser Thr Leu Pro Glu Glu Ala Thr Pro
420 425 430

Leu Ala Ile Ser His Gly Val Leu Pro Val Gln Thr Gly Trp Ser Ala
435 440 445

Glu Ser Thr Ser Arg Val Gln Ala Leu Lys Gln Leu Glu Asn His Arg
450 455 460

Pro Val Leu Glu Ala Met Gly Arg Gly Val Gln Trp Leu Lys Ala Leu
465 470 475 480

Gln Ser Lys Asp Gly Gly Trp Gly Ala Phe Asp Ser Asp Ile Asn Lys
485 490 495

Glu Leu Leu Thr Lys Val Pro Phe Ala Asp His Asn Ala Met Leu Asp
500 505 510

Glu Thr Asn Ala Asp Ile Ser Ala Arg Val Leu Glu Ala Tyr Ala Ala
515 520 525

Val Gly Ile Ser Phe Asn Asp Pro Ser Val Gln Arg Ala Leu Glu Phe
530 535 540

Ile Trp Asn Asp Gln Glu Asp Asp His Ala Trp Tyr Gly Arg Trp Gly
545 550 555 560

Val Asn Tyr Ile Tyr Gly Thr Trp Gln Val Leu Val Gly Leu Thr Ala
565 570 575

Ile Gly Ile Ser Ala His Asp Pro Arg Leu Val Arg Ala Ala Gly Trp
580 585 590

Leu Lys Ser Lys Gln Gln Ala Cys Gly Gly Trp Gly Glu Thr Pro Ala
595 600 605

Thr Tyr Asp Asn Pro Thr Leu Arg Gly Gln Gly Thr Pro Thr Ala Ser
610 615 620

Gln Thr Ala Trp Ala Val Leu Gly Leu Ile Ala Ala Gly Glu Gln Asn
625 630 635 640

Ser Ile Glu Cys Gln Arg Gly Val Glu Phe Leu Leu Lys Thr Gln Lys
645 650 655

His Asn Gly Thr Trp Asp Glu Glu Glu Phe Thr Gly Thr Gly Phe Pro
660 665 670

Arg Val Phe Tyr Leu Arg Tyr His Tyr Tyr Pro Leu Tyr Phe Pro Leu
675 680 685

Met Ala Leu Gly Arg Phe Ala Arg Ala Gly Gly Arg Val Asn Phe Ala
690 695 700

Gly
705


<210> 198
<211> 697
<212> PRT
<213> Planctomyces limnophilus

<400> 198
Met Glu Asp Leu Thr Gln Lys Leu Gln Gln Ala Leu Gln Leu Ala Ser
1 5 10 15

Arg Ala Leu Leu Asn Glu Arg Val Arg Pro Gly Leu Ala His Trp Glu
20 25 30

Gly Glu Leu Ser Thr Ser Ala Leu Ser Thr Ala Thr Ala Val Met Ala
35 40 45

Leu Phe Gln Tyr Ala Lys Cys Gln Gln Ala Ser Gly Arg Leu Gln Lys
50 55 60

Val Phe Asp Gly Lys Ser Glu Gly Asp Trp Arg Leu Ile Glu Gln Gly
65 70 75 80

Leu Ala Trp Leu Leu Gln His Gln Leu Ala Asp Gly Gly Trp Gly Asp
85 90 95

Thr Asp Lys Ser Ile Ser Asn Ile Ser Thr Thr Met Leu Ala His Ala
100 105 110

Thr Leu Val Ala Cys Arg Glu Ala Val Arg Gln Lys Ser Leu Val Leu
115 120 125

Asn Ala Ser Asp Ile Asp Ala Ala Ile Glu Arg Ser Gly Arg Leu Ile
130 135 140

Glu Glu Leu Gly Gly Ile Gln Ala Ile Arg Asp Arg Tyr Gly Lys Asp
145 150 155 160

His Thr Phe Ser Val Pro Ile Leu Thr His Ala Ala Leu Ala Gly Leu
165 170 175

Val Ser Trp Asn Glu Ile Pro Ala Leu Pro Tyr Glu Leu Ala Leu Leu
180 185 190

Pro His Arg Phe Phe Glu Val Ile Gln Leu Pro Val Val Ser Tyr Ala
195 200 205

Leu Pro Ala Leu Ile Ala Ile Gly Gln Thr Leu His Leu Arg Gln Arg
210 215 220

Thr Trp Asn Pro Trp Trp Trp Val Arg Arg Ala Ala Ile Pro Gly Thr
225 230 235 240

Leu Gln Lys Leu Gln Ser Ile Gln Pro Glu Ser Gly Gly Phe Leu Glu
245 250 255

Ala Thr Pro Leu Thr Ser Phe Val Thr Met Cys Leu Ala Ser Val Gly
260 265 270

Arg Val Asp His Pro Val Thr Gln Ala Gly Leu Lys Phe Ile Arg Asp
275 280 285

Ser Val Arg Pro Asp Gly Ser Trp Pro Ile Asp Thr Asn Leu Ala Thr
290 295 300

Trp Val Thr Thr Leu Ser Ile Asn His Leu Gly Ala Glu Ala Phe Ser
305 310 315 320

Ser Asp Glu Arg Glu Ala Leu Met Arg Trp Leu Leu Gln Gln Gln Tyr
325 330 335

Arg Thr Met His Pro Tyr Thr Asn Ala Ala Pro Gly Gly Trp Ala Trp
340 345 350

Thr Asn Leu Ser Gly Gly Val Pro Asp Ala Asp Asp Thr Pro Gly Ala
355 360 365

Met Leu Ala Leu Met Glu Leu Asp Arg Val Ser Val Ser Ser Gln Glu
370 375 380

Ser Leu Ser Ile Glu Gln Ala Leu Tyr Gln Ala Ala Leu Trp Leu Ile
385 390 395 400

Lys Leu Gln Asn Arg Asp Gly Gly Trp Pro Thr Phe Cys Arg Gly Trp
405 410 415

Gly Ala Leu Pro Phe Asp Arg Ser Ser Asn Asp Ile Thr Ala His Cys
420 425 430

Leu Arg Ala Leu Ile Gln Tyr Glu Arg Arg Leu Asn Asp Val Thr Val
435 440 445

Asp Ala Thr Gly Asp Thr Thr Ser Arg Pro Leu Ala Val Glu Val Pro
450 455 460

Ser Pro Lys Leu Arg Glu Gln Met Gln Arg Ser Ile Gln Gln Gly Phe
465 470 475 480

Glu Tyr Leu Glu Lys Thr Gln Arg Glu Asp Gly Ser Trp Leu Pro Leu
485 490 495

Trp Phe Gly Asn Gln His Ser Pro Asp Asp Glu Asn Pro Leu Tyr Gly
500 505 510

Thr Ala Arg Val Leu Leu Ala Tyr Ala Asp Ala Gly Leu Glu Gly Ser
515 520 525

Ser Ala Ala Leu Arg Gly Cys Asp Trp Leu Val Arg His Gln His Ala
530 535 540

Asp Gly Ala Trp Gly Pro Gly Thr Ser Ile Glu Thr Ala Asp Thr Ser
545 550 555 560

Asp Ala Glu Ser Asp Val Glu Gly Glu Pro Ala Ser Ile Glu Glu Thr
565 570 575

Ala Leu Ala Leu Met Ala Leu Cys Arg Phe Asp Ala Thr His Asn Val
580 585 590

Leu His Arg Gly Ala Ser Trp Leu Ile Thr Lys Val Glu Asn Glu Thr
595 600 605

Trp Arg Glu Pro Thr Pro Ile Gly Phe Tyr Phe Ala Lys Leu Trp Tyr
610 615 620

Tyr Glu Lys Leu Tyr Pro Gln Val Phe Thr Val Gly Ala Leu Lys Ala
625 630 635 640

Leu Ala Leu Arg Leu Gly Ser Ala Leu Thr Thr Val Ser Glu Asn Glu
645 650 655

Pro Ala Pro Ser Ser Ala Glu Pro Pro Ile Pro Pro Ile Ala Thr Asp
660 665 670

Arg Val Ala Asp Ser Met His Leu Gln Arg Thr Ser Pro Ser Ile Asn
675 680 685

Leu Ala Asn Gly Gly Ile Thr Leu Ala
690 695


<210> 199
<211> 620
<212> PRT
<213> Planctomyces maris

<400> 199
Met Ser Glu Thr Ile Ser Cys Gln Arg Ile Gln Ala Ala Tyr Gln Arg
1 5 10 15

Ser Arg Ala Glu Leu Leu Ser Leu Arg Asn Ser Thr Gly His Trp Thr
20 25 30

Gly Glu Leu Ser Thr Ser Ala Leu Ser Thr Ala Thr Ala Ile Met Ala
35 40 45

Leu Glu Met Ile Arg Arg Lys Arg Leu Pro Ala Asp Leu Ser Leu Asn
50 55 60

Thr Tyr Ile Asp Asn Gly Ile Arg Trp Leu Ala Glu His Gln Asn Ser
65 70 75 80

Asp Gly Gly Trp Gly Asp Thr Val Lys Ser Phe Ser Asn Ile Ser Thr
85 90 95

Thr Met Leu Cys His Ala Val Phe His Ala Thr Lys Ser Thr Glu Gln
100 105 110

Tyr Val Ser His Val Val Asn Ala Arg Gln Tyr Ile Asp Arg Val Gly
115 120 125

Gly Val Glu Ala Val Val Ala Arg Tyr Gly Lys Asp Lys Thr Phe Ser
130 135 140

Val Pro Ile Leu Thr His Cys Ala Leu Ala Gly Leu Val Lys Trp Lys
145 150 155 160

Thr Ile Pro Ala Leu Pro Phe Glu Leu Ala Cys Leu Pro Ala Arg Phe
165 170 175

Tyr Lys Thr Val Arg Leu Pro Val Val Ser Tyr Ala Leu Pro Ala Leu
180 185 190

Ile Ala Ile Gly Gln Val Arg His His Phe Cys Lys Pro Arg Asn Pro
195 200 205

Ile Thr Arg Leu Ile Arg Lys Leu Ala Val Lys Arg Ser Leu Lys Lys
210 215 220

Leu Ile Ser Ile Gln Pro Ser Asn Gly Gly Phe Leu Glu Ala Ala Pro
225 230 235 240

Leu Thr Ser Phe Val Thr Met Ser Leu Ala Gly Met Gly Leu Thr Asp
245 250 255

His Pro Val Val Gln Lys Gly Leu Gln Phe Leu Leu Asp Ser Val Arg
260 265 270

Pro Asp Gly Ser Trp Pro Ile Asp Thr Asn Leu Ala Thr Trp Thr Thr
275 280 285

Thr Leu Ser Val Asn Ala Leu Glu Gly Thr Leu Ala Glu Phe Glu Lys
290 295 300

Thr Pro Ile Arg Glu Trp Leu Leu Gln Gln Gln Tyr Lys Glu Leu His
305 310 315 320

Pro Tyr Thr Ser Ala Glu Pro Gly Gly Trp Ala Trp Thr Asp Leu Pro
325 330 335

Gly Gly Val Pro Asp Ala Asp Asp Thr Pro Gly Ala Ile Leu Ala Leu
340 345 350

Leu Asn Leu Gln Pro Asp Glu Pro Asp Thr Gln Gln Pro Ala Asp Leu
355 360 365

Gln Val Ala Leu Arg Asn Gly Val Lys Trp Leu Leu Asp Leu Gln Asn
370 375 380

Ser Asn Gly Gly Trp Pro Thr Phe Cys Arg Gly Trp Gly Ala Leu Pro
385 390 395 400

Phe Asp Gln Ser Ala Ala Asp Ile Ser Ala His Val Ile Arg Ala Leu
405 410 415

Gln Ala Trp Leu Gln Thr Glu Pro Glu Ser Ala Glu Ala Glu Leu Arg
420 425 430

Leu Arg Ala Glu Arg Ala Val Arg Lys Cys Phe Lys Tyr Leu Ala Thr
435 440 445

Val Gln Arg Pro Asp Gly Ser Trp Leu Pro Leu Trp Phe Gly Asn Gln
450 455 460

His Val Glu Asn Asp Glu Asn Pro Val Tyr Gly Thr Ala Arg Val Leu
465 470 475 480

Ala Ala Tyr Ala Gln Gly Glu Gln Cys Gly Ser Ile Gln Ala Glu Gln
485 490 495

Gly Ile Leu Phe Leu Lys Ser Val Gln Asn Leu Asp Gly Gly Trp Gly
500 505 510

Gly Ala Thr Ser Ala Pro Ser Ser Val Glu Glu Thr Ala Leu Ala Val
515 520 525

Asp Thr Leu Leu Ala Leu Gly Leu Glu Pro Ala Asp Pro Val Val Ala
530 535 540

Gln Gly Leu Asn Trp Leu Ser Gly Arg Val Glu Asn Gly Thr Tyr Thr
545 550 555 560

Glu Thr Thr Pro Ile Gly Phe Tyr Phe Ala Lys Leu Trp Tyr Phe Glu
565 570 575

Gln Leu Tyr Pro Ile Ile Phe Thr Val Ser Ala Leu His Arg Ala Glu
580 585 590

Thr Val Leu Lys Lys Ser Ala Asp Asp Asn Leu Arg Leu Ser Leu Glu
595 600 605

Glu Glu Asp Tyr Pro Ile Met Ser Val Lys Glu Lys
610 615 620


<210> 200
<211> 770
<212> PRT
<213> Polypodiodes niponica

<400> 200
Met Ala Leu Pro Phe Asn Gln Asp Ser Tyr Lys Gly Asp Asp Glu Ala
1 5 10 15

Asp Val Ser Lys Gly Ala Ala Lys Ser Pro Pro Ser Leu Glu Glu Ala
20 25 30

Ile Gln Arg Ser Gln Glu Phe Leu Leu Ala Gln Gln Phe Pro Glu Gly
35 40 45

Phe Trp Phe Gly Glu Leu Glu Ala Asn Val Thr Ile Ile Ser His Thr
50 55 60

Val Ile Leu Tyr Lys Leu Leu Gly Ile Glu Glu Asn Phe Pro Met Tyr
65 70 75 80

Lys Phe Glu Arg Tyr Leu Arg Arg Met Gln Cys Ser His Gly Gly Trp
85 90 95

Glu Ile Ala Tyr Gly Ile Gly Ser Tyr Leu Ser Ala Thr Ile Glu Ala
100 105 110

Tyr Ile Ala Leu Arg Leu Leu Asn Val Pro Gln Ser Asp Pro Ala Leu
115 120 125

Gln Lys Ala Leu Arg Val Ile Leu Asp Ser Gly Gly Val Thr Lys Ala
130 135 140

Arg Ile Phe Thr Lys Ile Cys Leu Ala Leu Leu Gly Ser Phe Asp Trp
145 150 155 160

Arg Gly Ile Pro Ser Leu Pro Pro Trp Leu Ile Leu Cys Pro Thr Trp
165 170 175

Phe Pro Leu Ser Ile Tyr Glu Val Ser Ser Trp Ala Arg Gly Cys Ile
180 185 190

Val Pro Leu Leu Val Ile Leu Asp Lys Lys Pro Val Phe Lys Val Ser
195 200 205

Pro Glu Val Ser Phe Asp Glu Leu Tyr Ala Glu Gly Arg Glu His Ala
210 215 220

Cys Lys Ile Ile Pro Ile Ser Gly Asp Trp Thr Ser Lys Phe Phe Ile
225 230 235 240

Thr Val Asp Arg Val Phe Lys Met Met Glu Arg Leu Arg Val Val Pro
245 250 255

Phe Arg Gln Trp Gly Ile Arg Glu Ala Glu Lys Trp Ile Leu Glu Arg
260 265 270

Gln Glu Glu Ser Gly Asp Tyr Val Asn Ile Phe Pro Ala Met Phe Tyr
275 280 285

Ser Val Met Cys Met Lys Val Leu Gly Tyr Glu Thr Thr Asp Pro Val
290 295 300

Val Gln Arg Ala Leu Leu Gly Phe Lys Gly Phe Thr Ile Glu Thr Ala
305 310 315 320

Asp Glu Cys Lys Val Gln Ser Thr Val Ser Pro Ile Trp Asp Thr Ala
325 330 335

Phe Ile Val Arg Ala Leu Val Asp Ser Gly Ile Pro Pro Asp His Pro
340 345 350

Ala Leu Gln Lys Ala Gly Gln Trp Leu Leu Gln Lys Gln Ile Leu Lys
355 360 365

His Gly Asp Trp Ala Phe Lys Asp Arg Gln Asn Pro Val Asn Gln Arg
370 375 380

Gly Phe Ala Cys Leu Gln Arg Asp Ser Gln Ile Glu Thr Ala Asp Glu
385 390 395 400

Cys Arg Val Gln Ser Thr Leu Ser Pro Val Trp Asp Thr Ala Phe Val
405 410 415

Val Lys Ala Leu Val Asp Ser Gly Ile Pro Pro Asn His Pro Ala Leu
420 425 430

Gln Lys Ala Gly Gln Trp Leu Leu Gln Asn Gln Thr Leu Thr His Gly
435 440 445

Asp Trp Ala Phe Lys Thr Gln Ser Gly His Leu Ala Ala Gly Gly Trp
450 455 460

Ala Phe Gln Ser His Asn Arg Trp Tyr Pro Asp Ala Asp Asp Ser Ala
465 470 475 480

Ala Val Met Met Ala Leu Asp Cys Ile Glu Leu Pro Asp Glu Asp Val
485 490 495

Lys Asn Gly Ala Ile Ala Arg Gly Leu Lys Trp Ile Ser Ala Leu Gln
500 505 510

Ser Arg Asn Gly Gly Trp Ala Gly Tyr Asp Lys Asn Cys Asp Gln Gln
515 520 525

Trp Ile Asn Lys Val Pro Phe Asn Asp Leu Asn Gly Ile Leu Asp Val
530 535 540

Pro Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met Val Gly Arg Leu
545 550 555 560

Ser Arg Leu Gly Ala Val Gly Thr Pro Tyr Ser Pro Arg His Cys Thr
565 570 575

Leu Val Glu Ser Ile Pro His Leu Leu Leu Pro Glu Thr Ile Ala Arg
580 585 590

Gly Leu Ala Tyr Leu Arg Arg Glu Gln Glu Gly Glu Gly Cys Trp Trp
595 600 605

Gly Lys Trp Gly Val Asn Tyr Ile Tyr Gly Thr Cys Gly Ala Leu Leu
610 615 620

Ala Leu Ser Gln Val Ala Pro Thr Thr His Gln Glu Glu Ile Ala Arg
625 630 635 640

Gly Ala Lys Trp Leu Ala Gln Val Gln Asn Arg Cys Asp Lys Gln Lys
645 650 655

Ala Ala Gln Gly Pro Arg Asp Gly Gly Trp Gly Glu Ser Cys Phe Ser
660 665 670

Tyr Asp Asp Pro Ala Leu Lys Gly Gln Asn Asp Ala Ser Thr Ala Ser
675 680 685

Gln Thr Ala Trp Ala Val Gln Gly Leu Leu Ala Ala Gly Asp Ala Leu
690 695 700

Gly Lys Tyr Glu Val Glu Ala Ile Glu Gln Gly Val Gln Tyr Leu Leu
705 710 715 720

Ala Thr Gln Arg Lys Asp Gly Thr Trp His Glu Ala His Phe Thr Gly
725 730 735

Ser Cys Phe Ala Gln His Phe Tyr Val Arg Tyr His Tyr Tyr Ala Gln
740 745 750

His Phe Pro Leu Ser Ala Leu Gly Leu Tyr Arg Thr Arg Ile Leu Gln
755 760 765

His Gln
770


<210> 201
<211> 692
<212> PRT
<213> Polypodiodes niponica

<400> 201
Met Leu Pro Tyr Asn Gln Asn Ser Tyr Lys Glu Ala Leu His Gly Gly
1 5 10 15

His Ala Ala His Asn Pro Pro Thr Leu Glu Glu Ala Ile Lys Arg Ser
20 25 30

Gln Glu Phe Leu Leu Ala His Gln His Pro Glu Gly Phe Trp Trp Gly
35 40 45

Asp Leu Glu Cys Asn Val Thr Ser Ala Ser His Thr Leu Ile Leu Tyr
50 55 60

Lys Ile Leu Gly Ile Ala Asp Arg Tyr Pro Leu His Lys Phe Glu Lys
65 70 75 80

Tyr Leu Arg Arg Met Gln Cys Ser His Gly Gly Trp Glu Met Ser Phe
85 90 95

Gly Asp Gly Gly Tyr Leu Ser Ala Thr Ile Glu Ala Tyr Ile Cys Leu
100 105 110

Arg Leu Leu Asn Val Pro Gln Ser Asp Pro Ala Leu Gln Arg Ala Leu
115 120 125

Lys Asn Ile Leu Ala Arg Gly Gly Val Thr Lys Ala Arg Val Phe Thr
130 135 140

Lys Val Cys Leu Ala Leu Leu Gly Gly Phe Asp Trp Ala Ala Leu Pro
145 150 155 160

Ser Leu Pro Pro Trp Leu Met Leu Phe Pro Ala Trp Phe Pro Trp Asn
165 170 175

Ile Tyr Glu Ala Ala Ser Trp Ala Arg Gly Cys Val Val Pro Leu Ile
180 185 190

Val Leu Leu Glu Lys Lys Pro Val Phe Gln Val Lys Pro Glu Val Ser
195 200 205

Phe Asp Glu Leu Tyr Val Glu Gly Arg Ala His Ala Cys Lys Ala Leu
210 215 220

Pro Phe Ser Ala His Asp Trp Val Ser Asn Ile Phe Val Ala Ala Asp
225 230 235 240

Arg Ala Phe Lys Leu Met Glu Arg Phe Gly Ala Val Pro Phe Arg Gln
245 250 255

Trp Ser Ile Lys Glu Ala Lys Lys Trp Val Leu Asp Arg Gln Glu Glu
260 265 270

Met Gly Asp Phe Ile Gly Tyr Asn Pro Pro Met Leu Tyr Phe Ala Val
275 280 285

Cys Leu Lys Leu Trp Gly Tyr Glu Val Thr Asp Pro Leu Leu Gln Arg
290 295 300

Ala Leu Leu Ala His Lys Lys Leu Thr Val Glu Thr Glu Asp Glu Cys
305 310 315 320

Trp Leu Gln Ser Ser Gln Ser Pro Val Trp Asp Thr Ala Leu Val Ile
325 330 335

Pro Ala Leu Val Glu Ser Gly Leu Pro Pro Asp His Pro Ala Leu Gln
340 345 350

Lys Ala Gly Gln Trp Leu Leu Glu Lys Gln Ile Leu Lys His Gly Asp
355 360 365

Trp Ala Leu Lys Thr Gly Gly Gly Arg Met Gln Asp Asp Ile Gly Gly
370 375 380

Gly Trp Ala Phe Gln Phe Val Asn Ser Trp Tyr Pro Asp Val Asp Asp
385 390 395 400

Ser Ala Ala Val Val Ile Ala Leu Asn Cys Ile Lys Met Pro Asp Glu
405 410 415

Asp Val Lys Asn Gly Ala Ile Ala Arg Cys Leu Lys Trp Ile Ala Phe
420 425 430

Met Gln Gly Arg Asn Gly Gly Trp Ala Ala Phe Asp Arg Asp Ser Asn
435 440 445

Gln Arg Trp Met Asp Ala Thr Pro Phe Ser Asp Ile Glu Ala Met Leu
450 455 460

Asp Val Ser Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met Val Gly
465 470 475 480

Leu Met Arg Leu Lys His Ala Ala Gln Pro Ala Asn Asn Ser Leu Gly
485 490 495

Lys Ala His Arg His Ile Ser Thr Glu Ser Ile Ala Arg Gly Val Asp
500 505 510

Tyr Leu Thr Lys Glu Gln Glu Lys Glu Gly Cys Trp Trp Gly Arg Trp
515 520 525

Gly Val Asn Tyr Ile Tyr Gly Thr Arg Gly Ala Leu Met Gly Leu Ser
530 535 540

Gln Val Ala Ala Lys Thr His Lys Lys Glu Ile Ala Arg Gly Ala Ala
545 550 555 560

Trp Leu Val Lys Val Gln Asn Lys Lys Asn Glu Lys Lys Gln Gly Ala
565 570 575

Gln Asp Gly Gly Trp Gly Glu Ala Cys Phe Ser Tyr Asp Asp Pro Ala
580 585 590

Thr Lys Gly Gln Asn Ser Arg Ser Thr Ala Ser Gln Thr Gly Trp Ala
595 600 605

Met Gln Gly Leu Leu Ala Ala Gly Glu Val Leu Gly Arg Lys Tyr Glu
610 615 620

Met Glu Ala Val Glu Glu Gly Val Gln Phe Leu Leu Asp Thr Gln Arg
625 630 635 640

Lys Asp Gly Ser Trp Ser Glu Ala Glu Phe Thr Gly Gly Gly Phe Pro
645 650 655

Lys His Tyr Tyr Leu Lys Tyr His Tyr Phe Ala Gln His Phe Pro Leu
660 665 670

Ser Ala Leu Ala Arg Tyr Arg Ala Arg Leu Leu Gln Leu Ser Arg Pro
675 680 685

Lys Asn Gln Ala
690


<210> 202
<211> 355
<212> PRT
<213> Populus trichocarpa

<400> 202
Met Val Tyr Ser Tyr Glu Met Met Val Leu Leu Asp Tyr Pro Glu Asp
1 5 10 15

His Pro Leu Arg Val Glu Cys Lys Ala Ala Leu Lys Lys Leu Val Val
20 25 30

His Arg Asp Asp Gly Ser Ser Tyr Cys Gln Pro Cys Leu Ser Pro Val
35 40 45

Trp Asp Thr Ala Trp Ser Val Met Ala Leu Glu Gln Ala Pro Ser Asp
50 55 60

Ala Arg Thr Glu Thr Ala Ile Ala Arg Ala Tyr Asp Trp Leu Thr Asp
65 70 75 80

Arg Gln Val Leu Asp Leu Arg Gly Asp Trp Glu Asn Asn Ala Ala Pro
85 90 95

Ser Thr Pro Pro Gly Gly Trp Ala Phe Gln Tyr Glu Asn Pro Tyr Tyr
100 105 110

Pro Asp Ile Asp Asp Ser Ala Val Val Leu Ala Met Leu His Ala Arg
115 120 125

Gly Lys Arg Thr Gly Gln Pro Gly Arg Tyr Glu Met Pro Val Ala Arg
130 135 140

Cys Leu Asp Trp Ile Ile Gly Leu Gln Ser Arg Asn Gly Gly Phe Gly
145 150 155 160

Ala Phe Asp Ala Asn Cys Asp Arg Asp Phe Leu Asn Ala Ile Pro Phe
165 170 175

Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly
180 185 190

Arg Val Leu Leu Ala Leu Gly Ile Thr Glu Arg Pro Gln Asp Ala Thr
195 200 205

Ala Arg Glu Arg Cys Ile Gln Tyr Leu Arg Asp Thr Gln Gln Pro Asp
210 215 220

Gly Ser Trp Trp Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp
225 230 235 240

Ser Val Leu Ala Gly Leu Gly Leu Ala Gly Val Asp Arg Lys Leu Pro
245 250 255

Met Val Arg Asn Gly Leu Gln Trp Leu Arg Gly Lys Gln Asn Ala Asp
260 265 270

Gly Gly Trp Gly Glu Thr Asn Asp Ser Tyr Ala Arg Pro Glu Leu Ala
275 280 285

Gly Lys His Glu Asp Gly Ser Met Ala Glu Gln Thr Ala Trp Ala Met
290 295 300

Leu Gly Gln Met Ala Val Gly Glu Gly Asp Ala Asp Ser Val His Arg
305 310 315 320

Gly Ala Ala Tyr Leu Leu Asp Ala Gln Asn Glu Asp Gly Phe Trp Met
325 330 335

His Pro Tyr His Asn Ala Pro Gly Phe Pro Arg Ile Phe His Leu Lys
340 345 350

Tyr His Gly
355


<210> 203
<211> 673
<212> PRT
<213> Ralstonia eutropha

<400> 203
Met Ser Met Asn Glu Ala Val Leu Ala Ala Pro Arg Ala Ala Val Ala
1 5 10 15

Thr Ala Ala Pro Ala Leu Gln Ala Pro Ile Glu Ala Leu Ser Pro Leu
20 25 30

Asp Ala Gly Ile Gly His Ala Val Asp Ala Leu Leu Ala Gln Gln Asn
35 40 45

Ala Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ala Thr Ile Pro
50 55 60

Ala Glu Tyr Val Leu Met Val His Tyr Leu Gly Glu Thr Pro Asp Leu
65 70 75 80

Ser Leu Glu Ala Arg Ile Ala Arg Tyr Leu Arg Arg Ile Gln Asn Ala
85 90 95

Asp Gly Gly Trp Pro Leu Phe His Glu Gly Arg Ser Asp Ile Ser Ala
100 105 110

Ser Val Lys Ala Tyr Phe Ala Leu Lys Met Ala Gly Asp Asp Pro Gln
115 120 125

Ala Ala His Met Ala Arg Ala Arg Glu Val Ile Leu Ala Met Gly Gly
130 135 140

Ala Glu Thr Ser Asn Val Phe Thr Arg Thr Leu Leu Ala Leu Tyr Gly
145 150 155 160

Val Met Pro Trp Gln Ala Val Pro Met Met Pro Val Glu Ile Met Leu
165 170 175

Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser Tyr Trp Ala
180 185 190

Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ser Leu Arg Pro Gln
195 200 205

Ala Arg Asn Pro Arg Lys Val Gly Ile Asp Glu Leu Phe Leu Gly Ser
210 215 220

Arg Asp Ala Val Arg Leu Pro Pro Arg Ala Pro His Gln His Lys Gly
225 230 235 240

Trp His Ala Leu Phe His Gly Ala Asp Val Leu Leu Arg Thr Ala Glu
245 250 255

His Val Met Pro Arg Gly Leu Arg Arg Arg Ala Ile Asp Ala Ala Lys
260 265 270

Ala Phe Val Arg Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile
275 280 285

Phe Pro Ala Met Ala Asn Ser Val Met Met Phe Asp Val Leu Gly Val
290 295 300

Pro Pro Asp Asp Pro Asp Arg Ala Ile Ala Arg Arg Ser Ile Asp Lys
305 310 315 320

Leu Leu Val Val His Gly Asp Glu Ala Tyr Cys Gln Pro Cys Leu Ser
325 330 335

Pro Val Trp Asp Thr Ala Leu Ala Ala His Ala Leu Leu Glu Ala Ser
340 345 350

Glu Pro Arg Ala Thr Ala Ala Val Thr Arg Ala Leu Asp Trp Leu Arg
355 360 365

Pro Leu Gln Val Leu Asp Val Arg Gly Asp Trp Thr Val Arg Arg Pro
370 375 380

Asp Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr
385 390 395 400

Pro Asp Val Asp Asp Thr Ala Val Val Val Ala Ala Met His Arg Ala
405 410 415

Ala Arg Thr Asp His Ser Gly Arg Ala Asp Pro Asn Ala Glu Ala Thr
420 425 430

Ala Arg Ala Ile Glu Trp Ile Val Gly Met Gln Ser Ala Asn Gly Gly
435 440 445

Trp Gly Ala Phe Glu Pro Glu Asn Thr His Leu Tyr Leu Asn Asn Ile
450 455 460

Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val
465 470 475 480

Ser Ala Arg Cys Leu Ser Met Leu Cys Gln Thr Gly Ala Thr Pro Asp
485 490 495

Lys Ser Glu Pro Ala Ala Arg Ala Leu Gln Tyr Leu Leu Ala Glu Gln
500 505 510

Leu Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr
515 520 525

Gly Thr Trp Ser Ala Leu Cys Ala Leu Asn Ala Ala Gly Leu Gly Pro
530 535 540

Asp Ala Pro Pro Leu Arg Arg Ala Ala Glu Trp Leu Val Ala Ile Gln
545 550 555 560

Asn Pro Asp Gly Gly Trp Gly Glu Asp Gly Asp Ser Tyr Lys Leu Glu
565 570 575

Tyr Arg Gly Tyr Glu Thr Ala Pro Ser Val Ala Ser Gln Thr Ala Trp
580 585 590

Ala Leu Leu Ala Leu Met Ala Ala Gly Gln Ala Ala His Pro Ala Val
595 600 605

Thr Arg Gly Ile Asp Tyr Leu Leu Arg Thr Gln Gln Ala Asp Gly Leu
610 615 620

Trp His Glu Pro Arg Phe Thr Ala Val Gly Phe Pro Arg Val Phe Tyr
625 630 635 640

Leu Arg Tyr His Gly Tyr Ala Arg Tyr Phe Pro Leu Trp Ala Leu Ala
645 650 655

Arg Tyr Arg Asn Leu Glu Arg Ser Gly Asn Arg Gln Val Ala Trp Gly
660 665 670

Leu


<210> 204
<211> 672
<212> PRT
<213> Ralstonia eutropha

<400> 204
Met Ser Met Asn Glu Thr Ala Phe Ala Thr Ala Val Pro Arg Ile Ala
1 5 10 15

Pro Ala Ser Ala Gly Asp Ser Pro Ala Pro Arg Asp Ala Ala Gln Ala
20 25 30

Leu Asp Gln Gly Ile Gly Arg Ala Ile Asp Ala Leu Leu His Gln Gln
35 40 45

Arg Pro Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ala Thr Ile
50 55 60

Pro Ala Glu Tyr Val Leu Met Val His Tyr Leu Gly Glu Ala Pro Asp
65 70 75 80

Leu Glu Leu Glu Ala Arg Leu Ala Arg Tyr Leu Arg Arg Ile Gln Asn
85 90 95

Pro Asp Gly Gly Trp Pro Leu Phe His Glu Gly Arg Ser Asp Val Ser
100 105 110

Ala Ser Val Lys Ala Tyr Phe Ala Leu Lys Met Ala Gly Asp Asp Pro
115 120 125

Gln Ala Ala His Met Gln Arg Ala Arg Arg Ala Val His Ala Leu Gly
130 135 140

Gly Ala Glu Ala Ser Asn Val Phe Thr Arg Thr Leu Leu Ala Leu Tyr
145 150 155 160

Gly Val Met Pro Trp Leu Ala Val Pro Met Met Pro Val Glu Ile Met
165 170 175

Leu Leu Pro Gln Trp Phe Pro Phe His Leu Ser Lys Val Ser Tyr Trp
180 185 190

Ala Arg Thr Val Ile Val Pro Leu Leu Val Leu Asn Ser Leu Arg Pro
195 200 205

Gln Ala Arg Asn Pro Arg Gly Val Gly Ile Asn Glu Leu Phe Val Gly
210 215 220

Asn Cys His Thr Val Gly Leu Pro Pro Arg Ala Ala His Gln His Ala
225 230 235 240

Gly Trp Tyr Thr Val Phe Arg Gly Leu Asp Ala Leu Leu Arg Val Ala
245 250 255

Glu Pro Leu Val Pro Arg Thr Leu Arg Arg Arg Ala Ile Ala Ala Ala
260 265 270

Gln Ala Phe Val Arg Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala
275 280 285

Ile Phe Pro Ala Met Ala Asn Ser Val Met Met Phe Asp Val Leu Gly
290 295 300

Val Pro Pro Asp Asp Pro Ala Arg Ala Leu Ala Arg Gln Ser Val Glu
305 310 315 320

Arg Leu Leu Val Glu His Gly Asp Glu Ala Tyr Cys Gln Pro Cys Leu
325 330 335

Ser Pro Val Trp Asp Thr Ala Leu Ala Ala His Ala Leu Leu Glu Thr
340 345 350

Gly Glu Ala Arg Ala Thr Ala Ala Ala Gly Arg Gly Leu Asp Trp Leu
355 360 365

Arg Pro Leu Gln Val Leu Asp Val Arg Gly Asp Trp Ala Val Arg Arg
370 375 380

Pro Leu Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Ala Tyr
385 390 395 400

Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Ala Ala Met Asn Arg
405 410 415

Tyr Met Arg Ala His Asp Val Pro Gly Arg Tyr Asp Glu Ala Val Ala
420 425 430

Arg Ala Ala Glu Trp Ile Val Gly Met Gln Gly Gly Asp Gly Gly Trp
435 440 445

Gly Ala Phe Glu Pro Glu Asn Thr His Leu Tyr Leu Asn Asn Ile Pro
450 455 460

Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser
465 470 475 480

Ala Arg Cys Leu Ser Met Leu Cys Gln Ile Gly Ala Thr Pro Gly Lys
485 490 495

Ser Glu Pro Ala Ala Arg Ala Leu Arg Tyr Leu Leu Ala Glu Gln Met
500 505 510

Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly
515 520 525

Thr Trp Ser Ala Leu Cys Ala Leu Asn Ala Thr Gly Leu Ala Pro Glu
530 535 540

Ala Pro Glu Met Arg Arg Ala Val Ala Trp Leu Glu Gln Ile Gln Asn
545 550 555 560

Ala Asp Gly Gly Trp Gly Glu Asp Gly Ser Ser Tyr Arg Leu Asp Tyr
565 570 575

Arg Gly Tyr Glu Pro Ala Pro Ser Val Ala Ser Gln Thr Ala Trp Ala
580 585 590

Leu Leu Ala Leu Met Ala Ala Gly Ala Ala Gln His Ala Ala Val Ala
595 600 605

Arg Gly Ile Asp Tyr Leu Leu Arg Thr Gln Gln Ser Gly Gly Leu Trp
610 615 620

His Glu Pro Arg Phe Thr Ala Val Gly Phe Pro Arg Val Phe Tyr Leu
625 630 635 640

Arg Tyr His Gly Tyr Ala Arg Tyr Phe Pro Leu Trp Ala Leu Ala Arg
645 650 655

Tyr Arg Asn Leu Gln Arg Gly Gly Ala His Gln Val Pro Trp Gly Leu
660 665 670




<210> 205
<211> 669
<212> PRT
<213> Ralstonia metallidurans

<400> 205
Met Asn Gln Ala Ala Thr Ile Thr Arg Pro Gln Asp Glu Thr Leu Thr
1 5 10 15

Thr Ser Ala Arg Arg Pro Ala Gln Pro Ala Leu Pro Asp Pro Leu Asp
20 25 30

Ala Gly Ile Ala His Val Val Glu Ser Leu Leu Ala Gln Gln Gln Ser
35 40 45

Asp Gly His Trp Val Tyr Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala
50 55 60

Glu Tyr Ile Leu Met Val His Tyr Leu Gly Glu Thr Pro Asp Leu Val
65 70 75 80

Leu Glu Gly Lys Ile Ala Asn Tyr Leu Arg Arg Ile Gln Asn Ala Asp
85 90 95

Gly Gly Trp Pro Leu Phe His Ala Gly Ala Ser Asp Ile Ser Ala Ser
100 105 110

Val Lys Gly Tyr Phe Ala Leu Lys Met Ala Gly Asp Asn Pro Glu Ala
115 120 125

Glu His Met Arg Arg Ala Arg Ala Ala Ile His Ala Met Gly Gly Ala
130 135 140

Glu Ala Ser Asn Val Phe Thr Arg Thr Leu Leu Ala Leu Tyr Gly Val
145 150 155 160

Met Pro Trp Gln Ala Val Pro Met Met Pro Val Glu Ile Met Leu Leu
165 170 175

Pro Glu Trp Phe Pro Phe His Leu Ser Lys Val Ser Tyr Trp Ala Arg
180 185 190

Thr Val Ile Val Pro Leu Leu Val Leu Asn Ser Leu Arg Pro Gln Ala
195 200 205

Arg Asn Pro Arg Lys Ile Gly Ile Asp Glu Leu Phe Val Arg Pro Cys
210 215 220

Gln Ala Thr Arg Leu Pro Arg Arg Ala Pro His Gln Ser Pro Leu Trp
225 230 235 240

Val Gly Val Phe Arg Thr Leu Asp Ala Val Val Arg Met Ala Glu Pro
245 250 255

Leu Phe Pro Arg Gly Leu Arg Gln Arg Ala Ile Glu Arg Ala Arg Glu
260 265 270

Phe Thr Val Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Phe
275 280 285

Pro Ala Met Val Asn Ser Val Leu Met Phe Asp Val Leu Gly Val Pro
290 295 300

Glu Ser Asp Pro Asn Arg Ala Ile Ala Arg Arg Ser Ile Asp Lys Leu
305 310 315 320

Leu Val Ile Lys Asp Asp Glu Ala Tyr Cys Gln Pro Cys Leu Ser Pro
325 330 335

Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu Glu Val Gly Glu
340 345 350

Pro Arg Thr Ile Ala Ala Ala Ala Arg Gly Leu Asp Trp Leu Leu Pro
355 360 365

Leu Gln Glu Leu Glu Leu Arg Gly Asp Trp Thr Val Arg Arg Pro Asn
370 375 380

Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Ala Asn Pro His Tyr Pro
385 390 395 400

Asp Val Asp Asp Thr Ala Val Val Ala Ala Ala Met Asp Arg Val Asp
405 410 415

Lys Gly Asp Arg Ser Asn Arg Tyr Asp Glu Ala Val Ser Arg Ala Cys
420 425 430

Glu Trp Ile Val Gly Met Gln Ser Ser Asn Gly Gly Trp Gly Ala Phe
435 440 445

Glu Pro Glu Asn Thr His Leu Tyr Leu Asn Asn Ile Pro Phe Ala Asp
450 455 460

His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser Ala Arg Cys
465 470 475 480

Leu Ala Met Leu Cys Gln Leu Gly Gln Met Pro Ala Asn Ser Glu Pro
485 490 495

Ala Ala Arg Ala Leu Arg Tyr Leu Leu Asp Glu Gln Glu Ala Asp Gly
500 505 510

Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser
515 520 525

Ala Leu Cys Gly Leu Asn Ala Ala Gly Ile Gly Thr Asp Ala Pro Glu
530 535 540

Met Lys Arg Ala Ala Gln Trp Leu Leu Ser Ile Gln Asn Glu Asp Gly
545 550 555 560

Gly Trp Gly Glu Ser Gly Asp Ser Tyr Lys Leu Glu Tyr Arg Gly Tyr
565 570 575

Glu Lys Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Met Leu Gly
580 585 590

Leu Met Ala Ala Gly Ala Gly Asp His Pro Ala Leu Val Arg Gly Val
595 600 605

Glu Tyr Leu Leu Arg Thr Gln Ala Ser His Gly Phe Trp Asp Glu Pro
610 615 620

Tyr Phe Thr Ala Val Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His
625 630 635 640

Gly Tyr Ser Arg Phe Phe Pro Leu Trp Ala Leu Ala Arg Phe Arg Asn
645 650 655

Leu Leu Arg Asp Gly Asn Arg Ala Ile Ser Trp Gly Leu
660 665


<210> 206
<211> 661
<212> PRT
<213> Ralstonia metallidurans

<400> 206
Met Thr Arg Lys Thr Ile Pro Ala Ser Glu Leu Asp Ala Ala Ile Val
1 5 10 15

Arg Ala Arg Asp Ala Leu Leu Asp Arg Gln His Pro Asp Gly His Trp
20 25 30

Cys Phe Glu Leu Glu Cys Asp Ala Thr Ile Thr Ala Glu Tyr Ile Leu
35 40 45

Met Met His Phe Val Asp Glu Ile Asp Thr Ala Leu Gln Ala Arg Met
50 55 60

Ala Lys Tyr Leu Arg Ala Val Gln Arg Leu Asp Gly His Gly Ala Trp
65 70 75 80

Asp Leu Tyr Phe Gly Gly Asp Leu Asp Ile Ser Cys Ser Val Lys Ala
85 90 95

Tyr Phe Ala Leu Lys Ala Ala Gly Asp Pro Pro Asp Ala Pro His Met
100 105 110

Val Arg Ala Arg Glu Ala Ile Leu Ala Arg Gly Gly Ala Ala Lys Ser
115 120 125

Asn Val Phe Thr Arg Ile Leu Leu Ala Thr Phe Gly Glu Ile Pro Trp
130 135 140

Arg Gly Thr Pro Phe Met Pro Val Glu Phe Val Leu Phe Pro Arg Trp
145 150 155 160

Ala Pro Ile His Met Asp Lys Val Ala Tyr Trp Ala Arg Thr Thr Met
165 170 175

Val Pro Leu Leu Val Leu Cys Ser Ile Arg Ala Ala Ala Lys Asn Pro
180 185 190

Leu Gly Val His Val Gln Glu Leu Phe Val Thr Pro Pro Glu Leu Glu
195 200 205

Arg Glu Tyr Phe Pro Arg Lys Arg Gly Leu Gln Gln Ala Phe Leu Val
210 215 220

Ala Asp Arg Val Val Arg His Leu Glu Pro Leu Ile Pro Arg Ala Leu
225 230 235 240

Arg Arg Arg Ala Ile Gln Arg Ala Val Glu Trp Ser Glu Ala Arg Met
245 250 255

Asn Gly Glu Asp Gly Phe Gly Gly Ile Phe Pro Pro Met Val Tyr Ser
260 265 270

Tyr Glu Met Met Val Leu Leu Asp Tyr Pro Glu Asp His Pro Leu Arg
275 280 285

Val Glu Cys Lys Ala Ala Leu Lys Lys Leu Val Val His Arg Asp Asp
290 295 300

Gly Ser Ser Tyr Cys Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Ala
305 310 315 320

Trp Ser Val Met Ala Leu Glu Gln Ala Pro Ser Asp Ala Arg Thr Glu
325 330 335

Thr Ala Ile Ala Arg Ala Tyr Asp Trp Leu Thr Asp Arg Gln Val Leu
340 345 350

Asp Leu Arg Gly Asp Trp Glu Asn Asn Ala Ala Pro Ser Thr Pro Pro
355 360 365

Gly Gly Trp Ala Phe Gln Tyr Glu Asn Pro Tyr Tyr Pro Asp Ile Asp
370 375 380

Asp Ser Ala Val Val Leu Ala Met Leu His Ala Arg Gly Lys Arg Thr
385 390 395 400

Gly Gln Pro Gly Arg Tyr Glu Met Pro Val Ala Arg Cys Leu Asp Trp
405 410 415

Ile Ile Gly Leu Gln Ser Arg Asn Gly Gly Phe Gly Ala Phe Asp Ala
420 425 430

Asn Cys Asp Arg Asp Phe Leu Asn Ala Ile Pro Phe Ala Asp His Gly
435 440 445

Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Ser Gly Arg Val Leu Leu
450 455 460

Ala Leu Gly Ile Thr Glu Arg Pro Gln Asp Ala Thr Ala Arg Glu Arg
465 470 475 480

Cys Ile Gln Tyr Leu Arg Asp Thr Gln Gln Pro Asp Gly Ser Trp Trp
485 490 495

Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Ala
500 505 510

Gly Leu Gly Leu Ala Gly Val Asp Arg Lys Leu Pro Met Val Arg Asn
515 520 525

Gly Leu Gln Trp Leu Arg Gly Lys Gln Asn Ala Asp Gly Gly Trp Gly
530 535 540

Glu Thr Asn Asp Ser Tyr Ala Arg Pro Glu Leu Ala Gly Lys His Glu
545 550 555 560

Asp Gly Ser Met Ala Glu Gln Thr Ala Trp Ala Met Leu Gly Gln Met
565 570 575

Ala Val Gly Glu Gly Asp Ala Asp Ser Val His Arg Gly Ala Ala Tyr
580 585 590

Leu Leu Asp Ala Gln Asn Glu Asp Gly Phe Trp Met His Pro Tyr His
595 600 605

Asn Ala Pro Gly Phe Pro Arg Ile Phe His Leu Lys Tyr His Gly Tyr
610 615 620

Thr Ala Tyr Phe Pro Leu Trp Ala Leu Gly Arg Tyr Arg Arg Leu Ala
625 630 635 640

Ala Ala Arg Ala Ser Ala Met Gln Thr Ala Lys Ala Glu Ser Ala Glu
645 650 655

Ser Met Thr Ala His
660


<210> 207
<211> 647
<212> PRT
<213> Rhizobium sp.

<400> 207
Met Asn Lys His Ser Gly Asn Arg Thr Ala Ile Asp Pro Ala Ala Leu
1 5 10 15

Glu Met Ser Ile Ala Ser Ala Thr Glu Ala Leu Leu Ala Tyr Arg His
20 25 30

Ala Asp Gly His Trp Ala Phe Glu Leu Glu Ala Asp Ser Thr Ile Pro
35 40 45

Ser Glu Tyr Ile Leu Leu Arg His Tyr Leu Ala Glu Pro Ile Asp Val
50 55 60

Val Leu Glu Ala Lys Ile Gly Asn Tyr Leu Arg Arg Thr Gln Gly Ala
65 70 75 80

His Gly Gly Trp Pro Leu Val His Asp Gly Pro Phe Asp Met Ser Ala
85 90 95

Ser Val Lys Ser Tyr Phe Ala Leu Lys Met Ile Gly Asp Ser Val Asp
100 105 110

Ala Ala His Met Val Lys Ala Arg Glu Ala Ile Arg Ala Arg Gly Gly
115 120 125

Ala Ala Asn Ser Asn Val Leu Thr Arg Phe Leu Leu Ala Leu Tyr Gly
130 135 140

Val Val Ser Trp Arg Ala Val Pro Val Leu Pro Ile Glu Ile Val Leu
145 150 155 160

Leu Pro Ile Trp Ser Pro Phe His Leu Tyr Lys Ile Ser Tyr Trp Ala
165 170 175

Arg Thr Thr Ile Val Pro Leu Met Val Leu Ala Val Leu Lys Pro Arg
180 185 190

Ala Lys Asn Pro Lys Gly Val Gly Ile Glu Glu Leu Phe Leu Gln Asp
195 200 205

Thr Lys Ser Val Gly Met Asn Pro Lys Ala Pro His Gln Ser Trp Gly
210 215 220

Trp Phe Leu Leu Phe Arg Gly Ile Asp Gly Ile Leu Arg Val Ile Glu
225 230 235 240

Pro His Leu Pro Lys Lys Leu Arg Glu Arg Ala Ile Ala Ser Ala Leu
245 250 255

Ala Phe Thr Glu Glu Arg Leu Asn Gly Glu Asp Gly Met Gly Ala Ile
260 265 270

Tyr Pro Ser Met Ala Asn Ile Val Met Met Tyr Asp Ala Leu Gly Lys
275 280 285

Asp Asp His Phe Pro Pro Arg Ala Ile Ala Arg Arg Ala Ile Asp Lys
290 295 300

Leu Leu Val Ile Gly Glu Glu Glu Ala Tyr Cys Gln Pro Cys Leu Ser
305 310 315 320

Pro Val Trp Asp Thr Ala Leu Thr Cys His Ala Leu Gln Glu Val Gly
325 330 335

Gly Ala Asn Ala Val Ala Lys Ala Lys Gln Gly Leu Asp Trp Leu Lys
340 345 350

Pro Arg Gln Val Leu Asp Val Lys Gly Asp Trp Ala Val Lys Ala Pro
355 360 365

Asn Ile Arg Pro Gly Gly Trp Pro Phe Gln Tyr Asn Asn Ala His Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Met Asp Arg Ala
385 390 395 400

Gln Arg His Ala Gly Ser Lys Glu Tyr Ala Thr Ala Ile Ala Arg Gly
405 410 415

Arg Glu Trp Ile Glu Gly Met Gln Ser Arg Asp Gly Gly Trp Ala Ala
420 425 430

Phe Asp Val Asn Asn Leu Glu Tyr Tyr Leu Asn Asn Leu Pro Phe Ala
435 440 445

Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg
450 455 460

Cys Val Ser Met Leu Ala Gln Val Gly Glu Phe Thr Gln Arg Ser Lys
465 470 475 480

Ala Val Ala Glu Gly Ile Ala Tyr Leu Arg Arg Thr Gln His Ala Glu
485 490 495

Gly Ser Trp Tyr Gly Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp
500 505 510

Ser Val Leu Cys Ala Leu Asn Ala Ala Gly Ile Asp His Gln Asp Pro
515 520 525

Met Ile Arg Lys Ala Val Glu Trp Leu Val Ser Ile Gln Ser Trp Asp
530 535 540

Gly Gly Trp Gly Glu Asp Ala Ile Ser Tyr Arg Leu Asp Tyr Ser Gly
545 550 555 560

Tyr Glu Gln Ala Pro Ser Thr Ser Ser Gln Thr Ala Trp Ala Leu Leu
565 570 575

Gly Leu Met Ala Ala Gly Glu Val Glu His Pro Ala Val Ala Arg Gly
580 585 590

Val Asn Tyr Leu Lys Asn Ala Gln Thr Glu Asn Gly Leu Trp Asp Glu
595 600 605

Gln Arg Tyr Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr
610 615 620

His Gly Tyr Ser Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg
625 630 635 640

Asn Leu Arg Ser Thr Asn Val
645


<210> 208
<211> 661
<212> PRT
<213> Rhodopirellula baltica

<400> 208
Met Met Ala Val Val Glu Asn Ser Val Ser Glu Val Leu Asp Arg Arg
1 5 10 15

Glu Leu Arg Gly Thr Leu Asp Leu Leu Arg Gly Glu Leu Leu Ala Gln
20 25 30

Arg Thr Lys Asp Gly His Trp Thr Gly Glu Leu Ser Ala Ser Ala Leu
35 40 45

Ser Thr Ala Thr Ala Ile Ser Ala Met Ser Ala Ala Val Arg Ser Gly
50 55 60

Lys Leu Ala Gly Ala Asp Lys Ala Ala Leu Leu Glu Gln Ile Gln Ser
65 70 75 80

Gly Arg Arg Trp Leu Ala Asp Gln Gln Asn Asp Asp Gly Gly Phe Gly
85 90 95

Asp Thr Asp Arg Ser His Ser Asn Ile Ala Thr Ser Tyr Leu Val Leu
100 105 110

Ala Ala Trp Thr Leu Ser Asp Gln Val Thr Gly Glu Thr Thr Asp Ala
115 120 125

Asn Ala Ile Ser Arg Leu Arg Asn Trp Ile Gln Leu Ala Gly Glu Leu
130 135 140

Asp Gly Leu Arg Arg Arg Tyr Gly Lys Asp Lys Thr Phe Val Val Pro
145 150 155 160

Ile Leu Thr Asn Met Ala Ile Ala Gly Leu Val Pro Trp Lys Lys Val
165 170 175

Ser Ala Leu Pro Phe Glu Ala Ala Val Val Pro Gln Ser Met Tyr Arg
180 185 190

Phe Val Gly Met Pro Val Val Ser Tyr Ala Val Pro Ala Leu Val Ala
195 200 205

Ile Gly Gln Val Lys Phe Leu Glu Gly Gly Gly Cys Leu Pro Pro Trp
210 215 220

Ser Leu Val Arg Arg Ala Ala Ile Glu Pro Ser Met Lys Val Leu Arg
225 230 235 240

Ser Met Gln Pro Ser Ser Gly Gly Tyr Leu Glu Ala Thr Pro Leu Thr
245 250 255

Ala Phe Val Val Met Ser Leu Ser Ala Ser Gly Arg Ala Asp His Glu
260 265 270

Val Thr Gln Asn Gly Leu Arg Phe Leu Arg Asp Ser Met Leu Pro Asp
275 280 285

Gly Ser Trp Pro Ile Asp Thr Asn Leu Ala Asn Trp Ala Thr Ser Leu
290 295 300

Ala Thr Thr Ala Leu Thr Met Asp Pro Asp Asp Asp Arg Ser Trp Ser
305 310 315 320

Thr Asn Glu Leu Ile Gln Trp Gln Arg Gly Cys Gln Tyr Gln Glu Arg
325 330 335

His Pro Phe Thr Gly Ala Asp Pro Gly Gly Trp Gly Trp Thr Asp Leu
340 345 350

Thr Gly Ser Val Pro Asp Ala Asp Asp Thr Pro Gly Ala Ile Ile Ser
355 360 365

Leu Arg Met Gln Ala Thr Thr Arg Pro Asp Pro Leu Cys Asp Asp Tyr
370 375 380

Ser Arg Asp Trp Pro Ala Ser Asp Ser Ser Gly Ser Val Ser Ala Asn
385 390 395 400

Ala Leu Asp Thr Trp Lys Ala Cys Asp Arg Gly Val Asp Trp Leu Leu
405 410 415

Gly Leu Gln Asn Arg Asp Gly Gly Trp Pro Thr Phe Cys Arg Gly Trp
420 425 430

Gly Lys Leu Pro Phe Asp Arg Ser Ser Asn Asp Leu Thr Ala His Ala
435 440 445

Leu Arg Ala Ile Ala Cys Leu Pro Lys Arg Glu Ser Ala Lys Arg Ser
450 455 460

Arg Ala Val Gln Arg Gly Leu Arg Phe Leu Arg Lys Asn Gln Gln Ala
465 470 475 480

Asp Gly Ser Trp Leu Pro Leu Trp Phe Gly Asn Gln Asp Arg Pro Glu
485 490 495

Glu Asp Asn Pro Ile Tyr Gly Thr Ser Arg Val Leu Val Asp Val Ser
500 505 510

Pro Ala Leu Gly His Asp Ala Ile Ser Arg Gly Leu Tyr Tyr Leu Ile
515 520 525

Asn Ser Gln Asn Ser Asp Gly Gly Trp Gly Gly Gly Glu Ser Val Arg
530 535 540

Glu Thr Phe Gly Leu Pro Glu Gly Phe Ile Ser Ser Val Glu Glu Thr
545 550 555 560

Ala Leu Ala Val Glu Ala Leu Val Ser Trp Trp Gly Arg Ile Pro Gly
565 570 575

Asn Glu Gly Gly Gln Ala Ala Glu Asn Asp Ile Pro Asp Gly Ser Pro
580 585 590

Trp Asp Ala Ser Met Arg Ser Ala Leu Arg Ala Ala Ile Leu Ser Gly
595 600 605

Thr Arg Trp Leu Ile Asp Ala Val Gln Arg Glu Arg His Gln Val Ala
610 615 620

Trp Pro Ile Gly Phe Tyr Phe Ala Lys Leu Trp Tyr Tyr Glu Arg Leu
625 630 635 640

Tyr Pro Leu Val Tyr Thr Thr Ala Ala Leu Gly Arg Val Met Gln Arg
645 650 655

Asp Glu Leu Leu Arg
660


<210> 209
<211> 685
<212> PRT
<213> Rhodopseudomonas palustris

<400> 209
Met Asp Ser Ile Leu Ala Pro Arg Ala Asp Ala Pro Arg Asn Ile Asp
1 5 10 15

Gly Ala Leu Arg Glu Ser Val Gln Gln Ala Ala Asp Trp Leu Val Ala
20 25 30

Asn Gln Lys Pro Asp Gly His Trp Val Gly Arg Ala Glu Thr Asn Ala
35 40 45

Thr Met Glu Ala Gln Trp Cys Leu Ala Leu Trp Phe Leu Gly Leu Glu
50 55 60

Asp His Pro Leu Arg Val Arg Leu Gly Arg Ala Leu Leu Asp Thr Gln
65 70 75 80

Arg Pro Asp Gly Ala Trp His Val Phe Tyr Gly Ala Pro Asn Gly Asp
85 90 95

Ile Asn Ala Thr Val Glu Ala Tyr Ala Ala Leu Arg Ser Leu Gly His
100 105 110

Arg Asp Asp Glu Glu Pro Leu Arg Lys Ala Arg Asp Trp Ile Leu Ser
115 120 125

Lys Gly Gly Leu Ala Asn Ile Arg Val Phe Thr Arg Tyr Trp Leu Ala
130 135 140

Leu Ile Gly Glu Trp Pro Trp Glu Lys Thr Pro Asn Ile Leu Pro Glu
145 150 155 160

Val Ile Trp Leu Pro Thr Trp Phe Pro Phe Ser Ile Tyr Asn Phe Ala
165 170 175

Gln Trp Ala Arg Ala Thr Leu Met Pro Ile Ala Val Leu Ser Ala His
180 185 190

Arg Pro Ser Arg Pro Leu Ala Pro Gln Asp Arg Leu Asp Ala Leu Phe
195 200 205

Pro Gln Gly Arg Asp Ser Phe Asn Tyr Asp Leu Pro Ala Arg Leu Gly
210 215 220

Ala Gly Val Trp Asp Val Ile Phe Arg Lys Ile Asp Thr Ile Leu His
225 230 235 240

Arg Leu Gln Asp Trp Gly Ala Arg Arg Gly Pro His Gly Ile Met Arg
245 250 255

Arg Gly Ala Ile Asp His Val Leu Gln Trp Ile Ile Arg His Gln Asp
260 265 270

Tyr Asp Gly Ser Trp Gly Gly Ile Gln Pro Pro Trp Ile Tyr Gly Leu
275 280 285

Met Ala Leu His Thr Glu Gly Tyr Ala Met Thr His Pro Val Met Ala
290 295 300

Lys Ala Leu Asp Ala Leu Asn Glu Pro Gly Trp Arg Ile Asp Ile Gly
305 310 315 320

Asp Ala Thr Phe Ile Gln Ala Thr Asn Ser Pro Val Trp Asp Thr Met
325 330 335

Leu Ser Leu Leu Ala Phe Asp Asp Ala Gly Leu Gly Glu Arg Tyr Pro
340 345 350

Glu Gln Val Glu Arg Ala Val Arg Trp Val Leu Lys Arg Gln Val Leu
355 360 365

Val Pro Gly Asp Trp Ser Val Lys Leu Pro Asp Val Lys Pro Gly Gly
370 375 380

Trp Ala Phe Glu Tyr Ala Asn Asn Phe Tyr Pro Asp Thr Asp Asp Thr
385 390 395 400

Ser Val Ala Leu Met Ala Leu Ala Pro Phe Arg His Asp Pro Lys Trp
405 410 415

Gln Ala Glu Gly Ile Glu Asp Ala Ile Gln Arg Gly Ile Asp Trp Leu
420 425 430

Val Ala Met Gln Cys Lys Glu Gly Gly Trp Gly Ala Phe Asp Lys Asp
435 440 445

Asn Asp Lys Lys Ile Leu Ala Lys Ile Pro Phe Cys Asp Phe Gly Glu
450 455 460

Ala Leu Asp Pro Pro Ser Ala Asp Val Thr Ala His Ile Ile Glu Ala
465 470 475 480

Phe Ala Lys Val Gly Leu Asp Arg Asn His Pro Ser Ile Val Arg Ala
485 490 495

Leu Asp Tyr Leu Lys Arg Glu Gln Glu Pro Glu Gly Pro Trp Phe Gly
500 505 510

Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ala Val Leu Pro Ala
515 520 525

Leu Ala Ala Ile Gly Glu Asp Met Arg Gln Pro Tyr Ile Ala Arg Ala
530 535 540

Cys Asp Trp Leu Ile Ala Arg Gln Gln Ala Asn Gly Gly Trp Gly Glu
545 550 555 560

Ser Cys Val Ser Tyr Met Asp Ala Lys Gln Ala Gly Glu Gly Thr Ala
565 570 575

Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Ala Leu Ile Ala Ala Asp
580 585 590

Arg Pro Gln Asp Arg Asp Ala Ile Glu Arg Gly Cys Leu Tyr Leu Thr
595 600 605

Glu Thr Gln Arg Asp Gly Thr Trp Gln Glu Val His Tyr Thr Gly Thr
610 615 620

Gly Phe Pro Gly Tyr Gly Val Gly Gln Thr Ile Lys Leu Asn Asp Pro
625 630 635 640

Leu Leu Ser Lys Arg Leu Met Gln Gly Pro Glu Leu Ser Arg Ser Phe
645 650 655

Met Leu Arg Tyr Asp Leu Tyr Arg His Tyr Phe Pro Met Met Ala Ile
660 665 670

Gly Arg Val Leu Arg Gln Arg Gly Asp Arg Ser Gly His
675 680 685


<210> 210
<211> 654
<212> PRT
<213> Rhodopseudomonas palustris

<400> 210
Met Asp Ser Gly Thr Phe Asn Pro Gly Gly Glu Arg Gly Asn Thr Leu
1 5 10 15

Asp Ala Ser Ile Asp Ala Ala Arg Ala Ala Leu Leu Gly Tyr Arg Arg
20 25 30

Asp Asp Gly His Trp Val Phe Glu Leu Glu Ala Asp Cys Thr Ile Pro
35 40 45

Ala Glu Tyr Val Leu Leu Arg His Tyr Leu Gly Glu Pro Ile Asp Ala
50 55 60

Ala Leu Glu Ala Lys Ile Ala Val Tyr Leu Arg Arg Thr Gln Gly Ala
65 70 75 80

His Gly Gly Trp Pro Leu Val Tyr Asp Gly Glu Phe Asp Met Ser Ala
85 90 95

Thr Val Lys Gly Tyr Phe Ala Leu Lys Met Ile Gly Asp Ser Ile Asp
100 105 110

Ala Pro His Met Ala Lys Ala Arg Glu Ala Ile Leu Ser Arg Gly Gly
115 120 125

Ala Val His Ala Asn Val Phe Thr Arg Phe Leu Leu Ala Met Phe Gly
130 135 140

Ile Leu Thr Trp Arg Ala Val Pro Val Leu Pro Val Glu Ile Met Leu
145 150 155 160

Leu Pro Met Trp Ser Pro Phe His Leu Asn Lys Ile Ser Tyr Trp Ala
165 170 175

Arg Thr Thr Ile Val Pro Leu Met Val Leu Ala Ala Leu Lys Pro Arg
180 185 190

Ala Val Asn Arg Leu Gly Val Gly Leu Asp Glu Leu Phe Leu Gln Asp
195 200 205

Pro Lys Ser Ile Gly Met Pro Ala Arg Gly Pro His Gln Asn Arg Gly
210 215 220

Leu Phe Ala Leu Phe Gly Ala Ile Asp Ala Val Leu Arg Val Ile Glu
225 230 235 240

Pro Leu Ile Pro Lys Lys Leu Arg Lys His Ala Ile Asp Arg Ala Val
245 250 255

Ala Phe Val Glu Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile
260 265 270

Tyr Pro Pro Met Ala Asn Thr Val Met Met Tyr Lys Val Leu Gly Tyr
275 280 285

Pro Glu Asp His Pro Pro Arg Ala Ile Thr Arg Arg Gly Ile Asp Leu
290 295 300

Leu Leu Val Ile Gly Glu Glu Glu Ala Tyr Cys Gln Pro Cys Val Ser
305 310 315 320

Pro Ile Trp Asp Thr Ser Leu Thr Cys His Ala Leu Leu Glu Ala Gly
325 330 335

Gly Ala Glu Ala Ala Gln Pro Val Arg Glu Gly Leu Asp Trp Leu Leu
340 345 350

Pro Lys Gln Val Leu Asp Leu Lys Gly Asp Trp Ala Val Lys Ala Pro
355 360 365

Asn Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala His Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Leu Asp Arg Ala
385 390 395 400

Arg Arg Asp Gln Pro Ser Ala Ala Tyr Asp Asn Ala Ile Ala Arg Gly
405 410 415

Arg Glu Trp Ile Glu Gly Met Gln Ser Asp Asp Gly Gly Trp Ala Ala
420 425 430

Phe Asp Val Asn Asn Thr Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ser
435 440 445

Asp His Gly Ala Met Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg
450 455 460

Cys Val Ser Met Leu Ala Gln Leu Gly Glu Thr Glu Gln Thr Ser Lys
465 470 475 480

Ala Val Ala Arg Gly Val Ala Tyr Leu Arg Lys Thr Gln Leu Pro Asp
485 490 495

Gly Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Ile Tyr Gly Thr Trp
500 505 510

Ala Val Leu Cys Ala Leu Asn Ala Ala Gly Val Asp His Gln Asp Pro
515 520 525

Ala Ile Arg Lys Ala Val Ala Trp Leu Ala Ser Ile Gln Asn Ala Asp
530 535 540

Gly Gly Trp Gly Glu Asp Gly Val Ser Tyr Arg Leu Asp Tyr Arg Gly
545 550 555 560

Tyr Glu Thr Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu
565 570 575

Ser Ile Met Ala Ala Gly Glu Val Asp His Pro Ala Val Ala Arg Gly
580 585 590

Ile Glu Tyr Leu Lys Gly Thr Gln Thr Glu Lys Gly Leu Trp Asp Glu
595 600 605

Gln Arg His Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr
610 615 620

His Gly Tyr Ser Lys Phe Phe Pro Leu Trp Gly Leu Ala Arg Tyr Arg
625 630 635 640

Asn Leu Arg Ala Thr Asn Ser Lys Val Val Gly Val Gly Met
645 650


<210> 211
<211> 654
<212> PRT
<213> Rhodopseudomonas palustris

<400> 211
Met Thr Ser Gly Thr Thr Ile Leu Gly Ala Glu Arg Gly Arg Thr Leu
1 5 10 15

Asp Ala Ser Ile Asp Ala Ala Arg Ala Ala Leu Leu Gly Tyr Arg Arg
20 25 30

Asp Asp Gly His Trp Val Phe Glu Leu Glu Ala Asp Cys Thr Ile Pro
35 40 45

Ala Glu Tyr Val Leu Leu Arg His Tyr Leu Gly Glu Pro Val Asp Ala
50 55 60

Ala Leu Glu Ala Lys Ile Ala Val Tyr Leu Arg Arg Thr Gln Gly Ala
65 70 75 80

His Gly Gly Trp Pro Leu Val His Asp Gly Glu Phe Asp Val Ser Ala
85 90 95

Thr Val Lys Ala Tyr Phe Ala Leu Lys Met Ile Gly Asp Ser Ile Asp
100 105 110

Ala Pro His Met Ala Lys Ala Arg Glu Ala Ile Leu Ala Arg Gly Gly
115 120 125

Ala Ile His Val Asn Val Phe Thr Arg Phe Leu Leu Ser Met Phe Gly
130 135 140

Ile Leu Thr Trp Arg Ser Val Pro Val Leu Pro Val Glu Ile Met Leu
145 150 155 160

Leu Pro Met Trp Ala Pro Phe His Leu Asn Lys Ile Ser Tyr Trp Ala
165 170 175

Arg Thr Thr Ile Val Pro Leu Met Val Leu Ala Ala Leu Lys Pro Arg
180 185 190

Ala Val Asn Lys Leu Asp Ile Gly Leu Asp Glu Leu Phe Leu Gln Asp
195 200 205

Pro Gln Ser Ile Gly Met Pro Ala Lys Ala Pro His Gln Ser Trp Gly
210 215 220

Leu Phe Thr Leu Phe Gly Ser Ile Asp Ala Val Leu Arg Val Ile Glu
225 230 235 240

Pro Leu Ile Pro Lys Lys Leu Arg Ser Tyr Ala Ile Gly Arg Ala Val
245 250 255

Ala Phe Ile Glu Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile
260 265 270

Tyr Pro Pro Met Ala Asn Thr Val Met Met Tyr Lys Val Leu Gly Tyr
275 280 285

Gly Glu Asp His Pro Pro Arg Ala Ile Thr Arg Arg Gly Ile Asp Leu
290 295 300

Leu Leu Val Val Gly Glu Glu Glu Ala Tyr Cys Gln Pro Cys Val Ser
305 310 315 320

Pro Ile Trp Asp Thr Ser Leu Thr Cys His Ala Leu Leu Glu Ala Gly
325 330 335

Gly Ala Glu Ala Ala Leu Pro Val Arg Lys Gly Leu Asp Trp Leu Ile
340 345 350

Pro Lys Gln Val Leu Asp Leu Lys Gly Asp Trp Ala Val Lys Ala Pro
355 360 365

Asn Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala His Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Leu Asp Arg Ala
385 390 395 400

Arg Arg Asp Gln Pro Ser Ala Ala Tyr Asp Asn Ala Ile Ala Arg Gly
405 410 415

Arg Glu Trp Ile Glu Gly Met Gln Ser Asp Asp Gly Gly Trp Ala Ala
420 425 430

Phe Asp Val Asn Asn Thr Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ser
435 440 445

Asp His Gly Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg
450 455 460

Cys Val Ser Met Leu Ala Gln Leu Gly Glu Thr Ala Glu Thr Ser Ser
465 470 475 480

Ala Leu Ala Arg Gly Val Ala Tyr Leu Arg Lys Thr Gln Leu Ala Glu
485 490 495

Gly Ser Trp Tyr Gly Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp
500 505 510

Ser Val Leu Cys Ala Leu Asn Ala Ala Gly Val Ala His Gln Asp Pro
515 520 525

Ala Met Arg Lys Ala Val Ala Trp Leu Ala Ser Ile Gln Asn Ala Asp
530 535 540

Gly Gly Trp Gly Glu Asp Ala Val Ser Tyr Arg Leu Asp Tyr Arg Gly
545 550 555 560

Tyr Glu Ser Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu
565 570 575

Ala Leu Met Ala Ala Gly Glu Val Asp His Pro Ala Val Ala Arg Gly
580 585 590

Val Glu Tyr Leu Lys Gly Thr Gln Thr Glu Lys Gly Val Trp Asp Glu
595 600 605

Gln Arg Tyr Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr
610 615 620

His Gly Tyr Ser Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg
625 630 635 640

Asn Leu Arg Ala Thr Asn Ser Lys Val Val Gly Val Gly Met
645 650


<210> 212
<211> 654
<212> PRT
<213> Rhodopseudomonas palustris

<400> 212
Met Glu Ser Gly Asn Asn Lys Gln Pro Ala Ala Ala Ile Gly Ala Leu
1 5 10 15

Asp Ala Ser Ile Glu Ser Ala Thr Asn Ala Leu Leu Gly Tyr Arg Gln
20 25 30

Pro Asp Gly His Trp Val Phe Glu Leu Glu Ala Asp Cys Thr Ile Pro
35 40 45

Ala Glu Tyr Val Leu Leu Arg His Tyr Leu Gly Glu Pro Val Asp Ala
50 55 60

Ala Leu Glu Ala Lys Ile Ala Asn Tyr Leu Arg Arg Val Gln Gly Ala
65 70 75 80

His Gly Gly Trp Pro Leu Val His Asp Gly Gly Phe Asp Met Ser Ala
85 90 95

Ser Val Lys Gly Tyr Phe Ala Leu Lys Met Ile Gly Asp Asp Ile Asp
100 105 110

Ala Pro His Met Ala Lys Ala Arg Glu Ala Ile Arg Ser Arg Gly Gly
115 120 125

Ala Ile His Ser Asn Val Phe Thr Arg Phe Leu Leu Ser Met Phe Gly
130 135 140

Ile Thr Thr Trp Arg Ser Val Pro Val Leu Pro Val Glu Ile Met Leu
145 150 155 160

Leu Pro Met Trp Ser Pro Phe His Leu Asn Lys Ile Ser Tyr Trp Ala
165 170 175

Arg Thr Thr Ile Val Pro Leu Met Val Leu Ala Ala Leu Lys Pro Arg
180 185 190

Ala Val Asn Arg Leu Asp Ile Gly Leu Asp Glu Leu Phe Leu Gln Asp
195 200 205

Pro Lys Ser Ile Lys Met Pro Ala Lys Ala Pro His Gln Ser Trp Ala
210 215 220

Leu Phe Lys Leu Phe Ala Gly Ile Asp Ala Val Leu Arg Thr Ile Glu
225 230 235 240

Pro Leu Phe Pro Lys Arg Leu Arg Asp His Ala Ile Lys Leu Ala Val
245 250 255

Asp Phe Val Glu Glu Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile
260 265 270

Tyr Pro Pro Met Ala Asn Thr Val Met Met Tyr Lys Val Leu Gly Phe
275 280 285

Pro Glu Asp His Pro Pro Arg Ala Ile Thr Arg Arg Gly Ile Asp Lys
290 295 300

Leu Leu Val Ile Gly Glu Asp Glu Ala Tyr Cys Gln Pro Cys Val Ser
305 310 315 320

Pro Val Trp Asp Thr Ala Leu Thr Cys His Ala Leu Leu Glu Val Gly
325 330 335

Gly Glu Ala Ala Val Pro Pro Ala Lys Arg Gly Met Asp Trp Leu Leu
340 345 350

Pro Lys Gln Val Leu Asp Leu Lys Gly Asp Trp Ala Val Lys Arg Pro
355 360 365

Asn Leu Arg Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala His Tyr
370 375 380

Pro Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Met Asp Arg Ser
385 390 395 400

Arg Arg Ala Thr Gly Ser Arg Glu Tyr Asp Glu Ala Ile Ala Arg Ala
405 410 415

Arg Glu Trp Ile Glu Gly Met Gln Ser Asp Asp Gly Gly Trp Ala Ala
420 425 430

Phe Asp Val Asn Asn Leu Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ser
435 440 445

Asp His Gly Ala Met Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg
450 455 460

Cys Val Ser Met Leu Ser Gln Leu Gly Glu Thr Ala Ala Ser Ser Lys
465 470 475 480

Ala Val Ala Asp Gly Val Glu Tyr Leu Arg Arg Thr Gln Leu Pro Asp
485 490 495

Gly Ser Trp Tyr Gly Arg Trp Gly Leu Asn Tyr Ile Tyr Gly Thr Trp
500 505 510

Ser Val Leu Cys Ala Leu Asn Ala Ala Gly Val Asp His Gln Asp Pro
515 520 525

Val Ile Arg Lys Ala Val Thr Trp Leu Ala Ser Val Gln Asn Pro Asp
530 535 540

Gly Gly Trp Gly Glu Gly Ala Glu Ser Tyr Arg Leu Asn Tyr Thr Arg
545 550 555 560

Tyr Glu Gln Ala Pro Thr Thr Ala Ser Gln Thr Ser Trp Ala Leu Leu
565 570 575

Gly Leu Met Ala Ala Gly Glu Val Asp Ser Pro Val Val Ala Arg Gly
580 585 590

Val Glu Tyr Leu Lys Ser Thr Gln Thr Gly Lys Gly Leu Trp Asp Glu
595 600 605

Gln Arg Tyr Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr
610 615 620

His Gly Tyr Ala Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg
625 630 635 640

Asn Leu Arg Ser Thr Asn Ser Lys Val Val Gly Val Gly Met
645 650


<210> 213
<211> 653
<212> PRT
<213> Rhodopseudomonas palustris

<400> 213
Met Asp Ser Gly Ser Tyr Thr Thr Gly Val Glu Arg Asn Ala Leu Glu
1 5 10 15

Ala Ser Ile Asp Ala Ala Arg Ser Ala Leu Leu Asn Tyr Arg Arg Asp
20 25 30

Asp Gly His Trp Val Phe Glu Leu Glu Ala Asp Cys Thr Ile Pro Ala
35 40 45

Glu Tyr Val Leu Leu Arg His Tyr Leu Gly Glu Pro Val Asp Ala Glu
50 55 60

Leu Glu Ala Lys Ile Ala Val Tyr Leu Arg Arg Ile Gln Gly Ala His
65 70 75 80

Gly Gly Trp Pro Leu Val His Asp Gly Asp Phe Asp Met Ser Ala Ser
85 90 95

Val Lys Gly Tyr Phe Ala Leu Lys Met Ile Gly Asp Ser Ile Asp Ala
100 105 110

Pro His Met Val Arg Ala Arg Glu Ala Ile Arg Ser Arg Gly Gly Ala
115 120 125

Ile His Ser Asn Val Phe Thr Arg Phe Leu Leu Thr Leu Tyr Gly Val
130 135 140

Thr Thr Trp Arg Ala Val Pro Val Leu Pro Val Glu Ile Met Leu Leu
145 150 155 160

Pro Ser Trp Ser Pro Phe Thr Leu Thr Lys Ile Ser Tyr Trp Ala Arg
165 170 175

Thr Thr Met Val Pro Leu Leu Val Leu Cys Ala Leu Lys Pro Gln Ala
180 185 190

Lys Asn Pro Lys Gly Val Gly Ile Asp Glu Leu Phe Leu Gln Asp Pro
195 200 205

Lys Thr Ile Gly Met Pro Val Lys Ala Pro His Gln Asn Trp Ala Leu
210 215 220

Phe Lys Leu Phe Gly Ser Ile Asp Ala Val Leu Arg Val Ile Glu Pro
225 230 235 240

Val Met Pro Lys Gly Ile Arg Lys Arg Ala Ile Asp Lys Ala Leu Ala
245 250 255

Phe Ile Glu Glu Arg Leu Asn Gly Glu Asp Gly Met Gly Ala Ile Phe
260 265 270

Pro Pro Met Ala Asn Ala Val Met Met Tyr Glu Ala Leu Gly Tyr Pro
275 280 285

Glu Asp Tyr Pro Pro Arg Ala Ser Gln Arg Arg Gly Ile Asp Leu Leu
290 295 300

Leu Val Asp Arg Gly Asp Glu Ala Tyr Cys Gln Pro Cys Val Ser Pro
305 310 315 320

Val Trp Asp Thr Ala Leu Ala Ser His Ala Val Leu Glu Ala Asp Gly
325 330 335

His Glu Gly Ala Lys Ser Val Arg Pro Ala Leu Asp Trp Leu Leu Pro
340 345 350

Arg Gln Val Leu Asp Val Lys Gly Asp Trp Ala Val Lys Ala Pro Asn
355 360 365

Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala His Tyr Pro
370 375 380

Asp Leu Asp Asp Thr Ala Val Val Val Met Ala Leu Asp Arg Ala Arg
385 390 395 400

Lys Asp Gln Pro Asn Pro Ala Tyr Asp Ala Ala Ile Ala Arg Ala Arg
405 410 415

Glu Trp Ile Glu Gly Met Gln Ser Asp Asp Gly Gly Trp Gly Ala Phe
420 425 430

Asp Ile Asn Asn Thr Glu Tyr Tyr Leu Asn Asn Ile Pro Phe Ser Asp
435 440 445

His Gly Ala Met Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg Cys
450 455 460

Val Ser Met Leu Ala Gln Leu Gly Glu Thr Met Asp Ser Ser Pro Ala
465 470 475 480

Leu Ala Arg Ala Val Gly Tyr Leu Arg Asp Thr Gln Leu Ala Glu Gly
485 490 495

Ser Trp Tyr Gly Arg Trp Gly Met Asn Tyr Ile Tyr Gly Thr Trp Ser
500 505 510

Val Leu Cys Ala Leu Asn Ala Ala Gly Val Pro His Ala Asp Pro Met
515 520 525

Ile Arg Lys Ala Val Ala Trp Leu Glu Ser Val Gln Asn Arg Asp Gly
530 535 540

Gly Trp Gly Glu Asp Ala Val Ser Tyr Arg Leu Asp Tyr Arg Gly Tyr
545 550 555 560

Glu Ser Ala Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala
565 570 575

Leu Met Ala Ala Gly Glu Val Asp His Pro Ala Val Ala Arg Gly Ile
580 585 590

Glu Tyr Leu Lys Ser Thr Gln Thr Glu Lys Gly Leu Trp Asp Glu Gln
595 600 605

Arg Tyr Thr Ala Thr Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His
610 615 620

Gly Tyr Ser Lys Phe Phe Pro Leu Trp Ala Leu Ala Arg Tyr Arg Asn
625 630 635 640

Leu Gln Ala Thr Asn Ser Lys Val Val Gly Val Gly Met
645 650


<210> 214
<211> 656
<212> PRT
<213> Rhodospirillum rubrum

<400> 214
Met Asp Ala Thr Ala Pro Leu Arg Asp Pro Gly Ala Pro Ser Ala Glu
1 5 10 15

Asn Cys Ser Val Asp Arg Arg Glu Leu Asp Asp Val Ile Gly Glu Ser
20 25 30

Cys Arg Trp Leu Gly Glu Arg Gln Asn Gln Asp Gly His Trp Val Phe
35 40 45

Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Ile Leu Leu Asn
50 55 60

His Phe Leu Asp Glu Ile Asp Asp Ala Arg Glu Ala Arg Ile Ala Ser
65 70 75 80

Tyr Leu Arg Ala Ile Gln Gly Lys His Gly Gly Trp Pro Leu Phe His
85 90 95

Asp Gly Asp Phe Asp Met Ser Ala Thr Val Lys Ala Tyr Tyr Ala Leu
100 105 110

Lys Leu Thr Gly Asp Gly Val Asp Glu Pro His Met Val Arg Ala Arg
115 120 125

Gln Ala Ile Leu Glu His Gly Gly Ala Glu Arg Thr Asn Val Phe Thr
130 135 140

Arg Phe Thr Leu Ala Met Phe Asp Gln Val Pro Trp Arg Ala Cys Pro
145 150 155 160

Val Thr Pro Val Glu Ala Leu Leu Leu Pro Arg Phe Ala Pro Phe His
165 170 175

Trp Ser Lys Val Ser Tyr Trp Ser Arg Thr Val Met Thr Pro Leu Met
180 185 190

Ile Leu Tyr Ser Arg Arg Ala Arg Ala Val Asn Pro Arg Gly Ile Gly
195 200 205

Val Arg Glu Leu Phe Arg Arg Asp Pro Glu Val Ile Arg Asp Trp Leu
210 215 220

Lys Asn Pro Thr Gly His Trp Ile Gly Asp Ala Leu Ile Gln Ile Asp
225 230 235 240

Lys Val Leu Arg Val Ile Glu Pro Ala Ile His Trp Ala Phe Arg Asp
245 250 255

Arg Ala Glu Lys Trp Ala Leu Asp Phe Ile Glu Glu Arg Leu Asn Gly
260 265 270

Arg Asp Gly Leu Gly Gly Ile Tyr Pro Ala Ile Ala Asn Thr Leu Met
275 280 285

Ala Tyr His Thr Leu Gly Tyr Ala Lys Asp His Pro Gly Tyr Arg Ile
290 295 300

Ala Arg Glu Ala Val Asp Gly Leu Cys Thr Pro His Ala Lys Gly Glu
305 310 315 320

Tyr Val Gln Pro Cys Leu Ser Pro Val Trp Asp Thr Cys Leu Ala Ser
325 330 335

His Ala Ile Gln Glu Ala Gly Gln Ser Ala Gly Asp Arg Ala Val Asp
340 345 350

Gln Ser Asn Ala Trp Leu Arg Glu Arg Gln Val Leu Asp Val Val Gly
355 360 365

Asp Trp Lys Ser Asn Arg Gly His Leu Arg Pro Gly Gly Trp Ala Phe
370 375 380

Gln Tyr Asn Asn Pro His Tyr Pro Asp Val Asp Asp Thr Ala Val Val
385 390 395 400

Val Met Ala Leu Ala Arg Ser Lys Glu Asp Glu Ala Asn Arg Glu Ala
405 410 415

Ile Ala Arg Ala Glu Glu Trp Ile Ile Gly Met Gln Ser Ser Asn Gly
420 425 430

Gly Trp Gly Ala Phe Asp Ala Glu Asn Glu His Asp Phe Leu Asn His
435 440 445

Val Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Val Asp
450 455 460

Val Ser Ala Arg Cys Leu Gly Met Leu Ala Gln Leu Gly Arg Pro Lys
465 470 475 480

Thr Asp Pro Val Val Ala Arg Gly Leu Asp Tyr Leu Trp Arg Glu Gln
485 490 495

Glu Ala Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr
500 505 510

Gly Thr Trp Ser Ala Leu Asn Ala Phe Asn Ala Val Glu Trp Asp Met
515 520 525

Thr Asp Pro Arg Ile Cys Lys Ala Val Asp Trp Leu Lys Ser Arg Gln
530 535 540

Arg Asp Asp Gly Gly Trp Gly Glu Asp Cys Ala Thr Tyr Trp Lys Glu
545 550 555 560

Arg Arg Ser Val Ser Lys Ala Ser Thr Pro Ser Gln Thr Ala Trp Ala
565 570 575

Val Leu Gly Leu Met Ala Ala Gly Glu Val Asp Ser Pro Glu Val Glu
580 585 590

Arg Gly Ile Arg Tyr Leu Leu Glu Ala Pro Arg Asp Gly Gly Lys Trp
595 600 605

Glu Glu Glu Leu Tyr Asn Ala Val Gly Phe Pro Arg Ile Phe Tyr Leu
610 615 620

Arg Tyr His Gly Tyr Ser Ala Tyr Phe Pro Leu Trp Ala Leu Ala Arg
625 630 635 640

Tyr Arg Asn Leu Thr Ser Gly Asn Cys Lys Arg Thr Ile His Gly Met
645 650 655




<210> 215
<211> 554
<212> PRT
<213> Rubrobacter xylanophilus

<400> 215
Met Gly Arg Gln Thr Arg Asn Leu Thr Arg Arg Glu Pro Ala Ala Glu
1 5 10 15

Ala Glu Glu Arg Gly Phe Arg Leu Leu Asp Ala His Arg Arg Ala Asp
20 25 30

Ser Ser Trp Val Gly Glu Leu Ser Ser Ser Ala Leu Ala Thr Ala Met
35 40 45

Ser Ala Leu Ala Leu Arg Leu Leu Gly His Pro Ala Glu Ser Gly Pro
50 55 60

Val Ala Gly Gly Leu Ala Trp Leu Ala Ala Thr Arg Asn Pro Asp Gly
65 70 75 80

Gly Trp Gly Asp Ala Pro Gly Glu Pro Ser Asn Met Asn Ala Thr Ser
85 90 95

Ile Ala Ala Ala Ala Leu Ala Arg Cys Ala Pro Arg Arg Tyr Arg Glu
100 105 110

Glu Val Ala Gly Gly Arg Arg Trp Val Glu Glu His Gly Gly Phe Ala
115 120 125

Ala Leu Asn Asp Pro Arg Thr Thr Thr Leu Ser Gly Pro Gly Arg Thr
130 135 140

Leu Trp Ala Leu Ala Gly Leu Val Pro Pro Glu Arg Val Arg Lys Leu
145 150 155 160

Pro Thr Glu Met Ile Leu Leu Pro Arg Arg Ile Arg Arg Thr Val Ser
165 170 175

Thr Thr Phe Pro Ala Phe Leu Ser Leu Ser Leu Leu His Glu Arg Phe
180 185 190

Arg Pro Ser Pro Arg Trp Arg Arg Pro Leu Arg Arg Arg Ala Glu Arg
195 200 205

Glu Ala Leu Ala Trp Leu Arg Arg Ala Gln Gly Pro Asn Gly Ser Tyr
210 215 220

Glu Glu Ser Ala Phe Leu Thr Ser Leu Ile Ala Ala Ala Leu Thr Ala
225 230 235 240

Ala Gly Ala Glu Gly Gly Asp Ile Val Arg Arg Ala Leu Pro Phe Val
245 250 255

Leu Arg Ser Arg Arg Pro Asp Gly Ser Trp Pro Ile Asp Arg Asp Leu
260 265 270

Glu Asn Phe Asp Thr Thr Gln Ala Ile Leu Ala His His Glu Ala Gly
275 280 285

Arg Pro Leu Arg Glu Ala Gly Arg Val Arg Glu Trp Leu Leu Asp Asn
290 295 300

Gln Phe Arg Arg Pro Phe Phe Pro Thr Ser Ser Pro Pro Gly Gly Trp
305 310 315 320

Ala Trp Ala Tyr Pro Ala Gly Trp Pro Asp Thr Asp Asp Thr Ala Cys
325 330 335

Ala Leu Arg Ser Leu Arg Leu Leu Gly Val Pro Ala Gly His Pro Ser
340 345 350

Ile Arg Leu Gly Leu Arg Trp Leu Tyr Arg Met Gln Asn Arg Asp Gly
355 360 365

Ser Trp Pro Thr Phe Val Arg Gly Ser Arg Met Pro Phe Asp His Gly
370 375 380

Cys Pro Tyr Ile Thr Ser Gln Val Leu Ser Ala Leu Ala Leu Met Gly
385 390 395 400

Pro Glu Ala Arg Arg Gly Ala Pro Leu Arg Arg Ala Leu Ala Tyr Leu
405 410 415

Arg Arg Ala Gln Arg Pro Asp Gly Ser Leu Gly Ser Leu Trp Phe Arg
420 425 430

Pro His Thr Arg Gly Thr Ala Ala Ala Val Glu Ala Phe Ser Asp Leu
435 440 445

Gly Leu Ser Gly Asp Pro Leu Val Gly Arg Ala Ala Arg Trp Leu Ala
450 455 460

Glu His Gln Asn Pro Asp Gly Gly Trp Gly Asp Gly His Gly Ala Pro
465 470 475 480

Ser Thr Ala Glu Glu Thr Ala Trp Ala Ser Ala Ala Leu Leu Arg Leu
485 490 495

Gly Gly Gly Glu Ala Ala Arg Lys Gly Val Arg Trp Leu Val Glu His
500 505 510

Gln Asp Pro Gly Gly Trp Lys Pro Ala Val Ile Gly Leu Tyr Tyr Ala
515 520 525

Ser Leu Ser Tyr Ser Asp Thr Phe Tyr Ala Leu Ser Tyr Pro Leu Val
530 535 540

Ala Leu Ala Arg His Arg Arg Leu Ser Arg
545 550


<210> 216
<211> 640
<212> PRT
<213> Saccharomonospora viridis

<400> 216
Met Thr Asp Val Leu Thr Arg Glu Leu Ser Pro Asn Ser Thr Arg Asp
1 5 10 15

Arg Val Arg Ser Cys Val Ser Ser Ala Arg Gln Tyr Leu Leu Ser Leu
20 25 30

Gln His Glu Glu Gly Trp Trp Lys Gly Glu Leu Asp Thr Asn Val Thr
35 40 45

Met Glu Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Gly Ile Ser Asp
50 55 60

Glu Gln Val Thr Gln Glu Thr Ala Arg Trp Ile Arg Ser Cys Gln Arg
65 70 75 80

Glu Asp Gly Thr Trp Ala Thr Phe His Gly Gly Pro Pro Asp Leu Ser
85 90 95

Thr Thr Val Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly Asp Ala Met
100 105 110

Asp Ala Ala His Leu Arg Lys Ala Arg Glu Tyr Ile Leu Asp Ser Gly
115 120 125

Gly Ile Glu Ser Thr Arg Val Phe Thr Arg Ile Trp Leu Ala Leu Phe
130 135 140

Gly Glu Trp Pro Trp Ser Arg Leu Pro Val Leu Pro Pro Glu Met Met
145 150 155 160

Leu Leu Pro Asp Trp Phe Pro Leu Asn Ile Tyr Asp Trp Ala Ser Trp
165 170 175

Ala Arg Gln Thr Val Val Pro Leu Thr Ile Val Gly Ser Leu Arg Pro
180 185 190

Thr Arg Asp Leu Gly Phe Ser Val Arg Glu Leu Arg Thr Gly Ile Gln
195 200 205

Arg Arg Asp Leu Glu Ser Pro Leu Ser Trp Ala Gly Val Phe His Gly
210 215 220

Leu Asp Ser Val Leu His Arg Leu Glu Lys Leu Pro Leu Lys Pro Leu
225 230 235 240

Arg Lys Val Ala Leu Ala Arg Ala Glu Gln Trp Ile Leu Asp Arg Gln
245 250 255

Glu Ser Asp Gly Gly Trp Gly Gly Ile Gln Pro Pro Trp Val Tyr Ser
260 265 270

Ile Leu Ala Leu His Leu Arg Gly Tyr Pro Leu Asp His Pro Val Leu
275 280 285

Arg Lys Ala Leu Asp Gly Leu Asp Gly Phe Thr Ile Arg His Arg Thr
290 295 300

Glu Asn Gly Trp Ile Arg Lys Leu Glu Ala Cys Gln Ser Pro Val Trp
305 310 315 320

Asp Thr Ala Leu Ala Met Thr Ala Leu Leu Asp Ser Gly Thr Pro Pro
325 330 335

Asn Asp Pro Ala Leu Val Arg Ala Ala Asp Trp Ile Leu Arg Gln Glu
340 345 350

Ile Arg Val Ser Gly Asp Trp Arg Val Arg Arg Pro Ala Leu Glu Pro
355 360 365

Ser Gly Trp Ala Phe Glu Phe Ala Asn Asp His Tyr Pro Asp Thr Asp
370 375 380

Asp Thr Ala Glu Val Val Leu Gly Leu Gln Arg Val Arg His Pro Glu
385 390 395 400

Pro His Arg Val Asn Ala Ala Val Glu Arg Ala Thr Ala Trp Leu Val
405 410 415

Gly Met Gln Ser Ser Asp Gly Gly Trp Gly Ala Phe Asp Ala Asp Asn
420 425 430

Thr Arg Thr Leu Cys Glu Lys Leu Pro Phe Cys Asp Phe Gly Ala Val
435 440 445

Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His Ile Val Glu Met Leu
450 455 460

Ala Ala Arg Gly Met Ala Asp Ser Glu Ser Ala Arg Arg Gly Val Arg
465 470 475 480

Trp Leu Leu Glu His Gln Glu Val Asp Gly Ser Trp Phe Gly Arg Trp
485 490 495

Gly Ala Asn His Val Tyr Gly Thr Gly Ala Val Val Pro Ala Leu Val
500 505 510

Ala Cys Gly Ile Ser Pro Gln His Glu Ala Val Arg Ala Ala Val Gln
515 520 525

Trp Leu Val Ala His Gln Asn Ala Asp Gly Gly Trp Gly Glu Asp Leu
530 535 540

Arg Ser Tyr Val Asp Arg Thr Trp Val Gly Arg Gly Thr Ser Thr Pro
545 550 555 560

Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala Ala Gly Glu Arg
565 570 575

Gly Glu Val Val Arg Arg Gly Val Glu Trp Leu Met Ala Ala Gln Arg
580 585 590

Pro Asp Gly Gly Trp Asp Glu Pro Gln Tyr Thr Gly Thr Gly Phe Pro
595 600 605

Gly Asp Phe Tyr Ile Ser Tyr His Met Tyr Arg Ile Val Phe Pro Leu
610 615 620

Thr Ala Leu Gly Arg Tyr Leu Gly Arg Gly Gly Asp Val Gly Thr Gly
625 630 635 640




<210> 217
<211> 636
<212> PRT
<213> Saccharopolyspora erythraea

<400> 217
Met Thr Glu Glu Val Leu Gln Arg Thr Ala Ala Pro Ala Glu Val Leu
1 5 10 15

Ala Ala Ala Arg Glu His Leu Leu Ser Leu Gln His Glu Arg Gly Trp
20 25 30

Trp Lys Gly Glu Leu Glu Thr Asn Val Thr Met Asp Val Glu Asp Leu
35 40 45

Leu Leu Arg Arg Phe Leu Gly Ile Leu Thr Thr Ala Glu Thr Glu Gln
50 55 60

Ala Ala Arg Trp Ile Arg Ser Arg Gln Arg Ala Asp Gly Thr Trp Ala
65 70 75 80

Gln Phe His Gly Gly Pro Gly Asp Leu Ser Thr Thr Val Glu Ala Tyr
85 90 95

Val Gly Leu Lys Leu Ala Gly Asp Asp Val Asp Ser Glu His Met Ala
100 105 110

Ala Ala Arg Ala Trp Ile Leu Glu Arg Gly Gly Ile Glu Glu Thr Arg
115 120 125

Val Phe Thr Arg Ile Trp Leu Ala Leu Phe Gly Glu Trp Ser Trp Asp
130 135 140

Asp Leu Pro Ala Met Pro Pro Glu Leu Val Leu Leu Pro Pro Trp Val
145 150 155 160

Pro Leu Asn Leu Ala Asp Trp Gly Cys Trp Ala Arg Gln Thr Ile Val
165 170 175

Pro Leu Thr Val Val Cys Thr Leu Arg Pro Arg Arg Asp Leu Gly Val
180 185 190

Gly Leu Ala Glu Leu Arg Ser Gly Arg Arg Arg Arg Lys Val Pro Ser
195 200 205

Pro Ser Trp Ala Gly Ala Phe Gln Val Leu Asp Gly Ala Leu His Gly
210 215 220

Tyr Gln Arg His Pro Leu Arg Gly Leu Arg Glu His Ala Met Arg Arg
225 230 235 240

Ala Ala Glu Trp Ile Val Ala Arg Gln Glu Ala Asp Gly Ser Trp Gly
245 250 255

Gly Ile Gln Pro Pro Trp Val Tyr Ser Leu Leu Ala Leu His Leu Leu
260 265 270

Gly Tyr Pro Leu Asp His Pro Val Leu Arg Gln Gly Leu Ala Gly Leu
275 280 285

Glu Arg Phe Leu Ile Arg Glu Glu Thr Pro Glu Gly Thr Val Arg Arg
290 295 300

Leu Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Val Leu Ser Met Gln
305 310 315 320

Ala Leu Arg Asp Ala Gly Leu Ala Ala Asp His Pro Ala Leu Arg Arg
325 330 335

Ala Ala Asp Phe Val Leu Ala Glu Glu Ile Arg Val Lys Gly Asp Trp
340 345 350

Ser Val Arg Arg Pro Asp Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe
355 360 365

Asp Asn Asp Gly Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu
370 375 380

Ala Leu Asn Arg Val Asp His Glu Arg Pro Gly Ala Val Asn Ala Ala
385 390 395 400

Ile Asp Arg Gly Val Arg Trp Met Ser Gly Met Gln Ser Ala Asp Gly
405 410 415

Gly Trp Gly Ala Phe Asp Ala Asp Asn Thr Arg Glu Leu Val Asn Glu
420 425 430

Leu Pro Phe Cys Asp Phe Gly Ala Val Ile Asp Pro Pro Ser Ala Asp
435 440 445

Val Thr Ala His Val Val Glu Ala Leu Cys Val Leu Gly Arg Gly Asp
450 455 460

Gly Glu Ala Val Arg Arg Gly Val Arg Trp Leu Leu Asp His Gln Glu
465 470 475 480

Leu Asp Gly Ser Trp Phe Gly Arg Trp Gly Ala Asn His Val Tyr Gly
485 490 495

Thr Gly Ala Ala Val Pro Ala Leu Val Arg Ala Gly Leu Arg Arg Asp
500 505 510

His Leu Ala Leu Arg Arg Ala Val Arg Trp Leu Glu Val His Gln Asn
515 520 525

Asp Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Asp Asp Pro Val
530 535 540

Trp Val Gly Arg Gly Arg Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu
545 550 555 560

Leu Ala Leu Leu Ala Val Asp Leu His Asp Thr Asp Ala Val Arg Arg
565 570 575

Gly Val Gly Phe Leu Ala Glu Thr Gln Arg Pro Asp Gly Thr Trp Asp
580 585 590

Glu Pro Gln Phe Thr Gly Thr Gly Phe Pro Gly Asp Phe Tyr Ile Asn
595 600 605

Tyr His Leu Tyr Arg Leu Val Phe Pro Val Thr Ala Leu Gly Arg Tyr
610 615 620

Glu Gln Ala Arg Arg Glu Gln Ser Gly Gly Ser Gly
625 630 635


<210> 218
<211> 656
<212> PRT
<213> Schizosaccharomyces japonicus

<400> 218
Met Lys Thr Asp Gly Asn Thr Thr Leu Asp Thr Thr Ile Ser Met Glu
1 5 10 15

Glu Leu Glu Arg Thr Val Lys Ser Ala Tyr Glu Ala Leu Ala Lys Asp
20 25 30

Gln Gln Asp Asp Gly His Trp Ile Tyr Glu Leu Glu Ala Asp Val Thr
35 40 45

Ile Pro Ala Gln Phe Ile Leu Leu Glu His Thr Leu Asp Lys Ile Asp
50 55 60

Glu Glu Leu Glu Gln Lys Ile Ala Asn Tyr Leu Arg Arg Cys Gln Ser
65 70 75 80

Arg Glu His Trp Gly Trp Pro Val Tyr Tyr Gly Gly Glu Phe Asn Ile
85 90 95

Ser Ala Ser Val Gln Ala Tyr Phe Ala Leu Lys Met Thr Gly Glu Asp
100 105 110

Ile Asn Ala Pro His Met Val Arg Ala Arg Glu Ala Ile Leu Ala His
115 120 125

Gly Gly Pro Glu Tyr Ala Asn Val Phe Thr Arg Ile Gln Leu Ser Leu
130 135 140

Phe Gly Glu Ala Ser Trp Leu Ala Thr Pro Phe Met Pro Val Glu Ile
145 150 155 160

Met Leu Leu Pro Arg Trp Met Tyr Phe Ser Ile Trp Asn Met Ser Tyr
165 170 175

Trp Ser Arg Thr Thr Val Ala Pro Leu Leu Ile Val Ala Asp Leu Lys
180 185 190

Pro Lys Ala Ile Asn Pro Arg Asn Val His Ile Pro Glu Leu Phe Pro
195 200 205

Thr Pro Pro Asp Lys Val Lys Thr Trp Ile His Gly Pro Phe Arg Ser
210 215 220

Lys Trp Gly His Val Phe Lys Phe Ile Asp Thr Ala Ile Arg Pro Phe
225 230 235 240

Thr Arg Phe Val Pro Ser Phe Leu His Lys Lys Ala Tyr Lys Ala Ala
245 250 255

Leu Asp Phe Ile Glu Pro Arg Leu Asn Gly Val Asp Gly Leu Gly Ala
260 265 270

Ile Tyr Pro Pro Met Ser Tyr Ser Ala Val Met Tyr Arg Ala Leu Gly
275 280 285

Ile Pro Asp Asp Asp Pro Arg Ala Ala Thr Asn Trp Glu Ala Leu Lys
290 295 300

Gly Leu Leu Val Ile Lys Glu Arg Glu Ala Tyr Cys Gln Ala Cys Val
305 310 315 320

Ser Pro Val Trp Asp Thr Ala Leu Ser Gly His Ala Leu Met Glu Ala
325 330 335

Ser Phe Gly Pro Asp Gly Ile Asn Ala Asp Arg Thr Glu Lys Leu Ile
340 345 350

Asp Arg Ala Ala His Trp Leu Arg Ala His Gln Val Leu Asn Val Val
355 360 365

Gly Asp Trp Ala Ile Asn Asn Pro Asn Leu Gln Pro Gly Gly Trp Ala
370 375 380

Phe Gln Tyr Gly Asn Asp Tyr Tyr Pro Asp Val Asp Asp Thr Ala Val
385 390 395 400

Ala Ala Met Leu Leu His Arg Gln Asn Leu Pro Glu Asn Glu Glu Ala
405 410 415

Leu Asp Arg Ala Arg Lys Trp Ile Ile Gly Met Gln Ser Ser Asn Gly
420 425 430

Gly Trp Gly Ala Phe Asp Ile Asp Asn Asp Lys Gln Ile Leu Asn Asp
435 440 445

Ile Pro Phe Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp
450 455 460

Val Ser Ala Arg Cys Ile Ser Leu Leu Ala Glu Leu Gly His Pro Glu
465 470 475 480

Asp Arg Pro Val Ile Glu Arg Gly Ile Lys Tyr Leu Arg Lys Glu Gln
485 490 495

Glu Glu Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Ile Tyr
500 505 510

Gly Ala Trp Ser Val Leu Cys Ala Phe Asn Ala Ser Gly Val Pro His
515 520 525

Asp Asp Pro Ser Val Leu Lys Cys Val Asn Phe Leu Lys Ser Val Gln
530 535 540

Arg Glu Asp Gly Gly Trp Gly Glu Ser Cys Glu Thr Tyr Glu Gly Ser
545 550 555 560

Ala His Gly Val Tyr Thr Glu Ser Leu Pro Ser Gln Thr Ala Trp Ala
565 570 575

Val Leu Gly Leu Met Ala Ser Gly Arg Arg Thr Asp Pro Ala Val Lys
580 585 590

Arg Gly Ile Val Trp Leu Ile Gln His Gln Gln Asp Asn Gly Glu Trp
595 600 605

Ala Glu Glu Pro Phe Asn Ala Val Gly Phe Pro Arg Met Phe Tyr Leu
610 615 620

His Tyr Leu Gly Tyr Lys Gln Phe Phe Pro Leu Leu Ala Leu Ala Arg
625 630 635 640

Tyr Arg His Met Glu Lys Ser Gly Thr Asn Asn Val Ser Phe Ala Phe
645 650 655




<210> 219
<211> 617
<212> PRT
<213> Sphaerobacter thermophilus

<400> 219
Met Asp Pro Ala Leu Ser Arg Ala Val Asp Trp Leu Leu Glu His Gln
1 5 10 15

Asp Pro Ala Gly Trp Trp Cys Gly Glu Phe Glu Thr Asn Val Thr Ile
20 25 30

Thr Ala Glu His Ile Leu Leu Leu Arg Phe Leu Gly Leu Asp Pro Ser
35 40 45

Pro Leu Arg Asp Ala Val Thr Arg Tyr Leu Leu Gly Gln Gln Arg Glu
50 55 60

Asp Gly Ser Trp Ala Leu Tyr Tyr Glu Gly Pro Ala Asp Leu Ser Thr
65 70 75 80

Ser Ile Glu Ala Tyr Ala Ala Leu Lys Val Leu Gly Leu Asp Pro Thr
85 90 95

Ser Glu Pro Met Arg Arg Ala Leu Gln Val Ile His Asp Leu Gly Gly
100 105 110

Val Ala Gln Ala Arg Val Phe Thr Arg Ile Trp Leu Ala Met Phe Gly
115 120 125

Gln Tyr Pro Trp Asp Gly Val Pro Ser Met Pro Pro Glu Leu Ile Trp
130 135 140

Leu Pro Pro Ser Ala Pro Phe Asn Leu Tyr Asp Phe Ala Cys Trp Ala
145 150 155 160

Arg Ala Thr Ile Thr Pro Leu Leu Ile Ile Leu Ala Arg Arg Pro Val
165 170 175

Arg Pro Leu Gly Cys Asp Leu Gly Glu Leu Val Leu Pro Gly Ser Glu
180 185 190

His Leu Leu Thr Arg Val Pro Gly Ser Gly Pro Phe Trp Trp Gly Asp
195 200 205

Lys Val Leu Lys Arg Tyr Asp His Leu Val Arg His Pro Gly Arg Asp
210 215 220

Arg Ala Cys Gln Arg Ile Val Glu Trp Ile Ile Ala Arg Gln Glu Ala
225 230 235 240

Asp Gly Ser Trp Gly Gly Ile Gln Ser Ala Trp Val Met Ser Leu Ile
245 250 255

Ala Leu His Leu Glu Gly Leu Pro Leu Asp His Pro Val Met Arg Ala
260 265 270

Gly Leu Ala Gly Phe Asp Arg Val Ala Leu Glu Asp Glu Arg Gly Trp
275 280 285

Arg Leu Gln Ala Ser Thr Ser Pro Val Trp Asp Thr Ala Trp Ala Val
290 295 300

Leu Ala Leu Arg Arg Ala Gly Leu Pro Arg Glu His Pro Arg Leu Ala
305 310 315 320

Leu Ala Val Asp Trp Leu Leu Gln Glu Gln Ile Pro Gly Gly Gly Asp
325 330 335

Trp Gln Val Arg Thr Gly Thr Ile Pro Gly Gly Gly Trp Ala Phe Glu
340 345 350

Phe Asp Asn Asp His Tyr Pro Asp Ile Asp Asp Thr Ala Val Val Val
355 360 365

Leu Ala Leu Leu Glu Ala Gly His Glu Asp Arg Val Arg Asn Ala Val
370 375 380

Glu Arg Ala Ala Arg Trp Ile Leu Ala Met Arg Ser Thr Asp Gly Gly
385 390 395 400

Trp Gly Ala Phe Asp Arg Asp Asn Ala Arg Glu Val Ile His Arg Leu
405 410 415

Pro Ile Ala Asp Phe Gly Thr Leu Ile Asp Pro Pro Ser Glu Asp Val
420 425 430

Thr Ala His Val Leu Glu Met Leu Ala Arg Leu Ser Phe Pro Ser Thr
435 440 445

Asp Pro Val Val Ala Arg Gly Leu Glu Phe Leu Gln Gln Thr Gln Arg
450 455 460

Pro Asp Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
465 470 475 480

Thr Trp Cys Ala Val Ser Ala Leu Thr Ala Phe Ala Asp Thr Asp Ala
485 490 495

Thr Ala Arg Ala Met Val Pro Arg Ala Val Ala Trp Leu Leu Asp Arg
500 505 510

Gln Asn Ala Asp Gly Gly Trp Gly Glu Thr Cys Gly Ser Tyr Glu Asp
515 520 525

Pro Asn Leu Ala Gly Val Gly Arg Ser Thr Pro Ser Gln Thr Ala Trp
530 535 540

Ala Val Leu Ala Leu Gln Ala Ala Gly Leu Gly Gln His Pro Ala Cys
545 550 555 560

Arg Arg Gly Leu Asp Phe Leu Arg Glu Arg Gln Val Gly Gly Thr Trp
565 570 575

Glu Glu Arg Glu His Thr Gly Thr Gly Phe Pro Gly Asp Phe Phe Ile
580 585 590

Asn Tyr His Leu Tyr Arg His Val Phe Pro Thr Met Ala Leu Ala Gly
595 600 605

Ala Ala Thr Gly Met Asp Ser Pro Arg
610 615


<210> 220
<211> 583
<212> PRT
<213> Streptomyces albus

<400> 220
Phe Leu Gly Ile Arg Asp Glu Ala Thr Thr Arg Ser Ala Ala Leu Phe
1 5 10 15

Ile Arg Gly Glu Gln Arg Glu Asp Gly Thr Trp Ala Thr Phe His Gly
20 25 30

Gly Pro Pro Asp Leu Ser Thr Thr Val Glu Ala Tyr Val Ala Leu Arg
35 40 45

Leu Ala Gly Asp Ser Pro Asp Ala Pro His Met Thr Arg Ala Ala His
50 55 60

Trp Val Arg Ser Gln Gly Gly Ile Ala Glu Ala Arg Val Phe Thr Arg
65 70 75 80

Ile Trp Leu Ala Leu Phe Gly Trp Trp Pro Trp Asp Arg Leu Pro Glu
85 90 95

Leu Pro Pro Glu Leu Ile Phe Leu Pro Pro Trp Ala Pro Leu Asn Ile
100 105 110

Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Val
115 120 125

Val Ser Ala Lys Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu
130 135 140

Leu His Thr Asp Pro Ala Asp Pro Ala Pro Arg Ala Arg Phe Ala Pro
145 150 155 160

Leu Ala Ser Trp Asn Gly Ala Phe Gln Arg Leu Asp Arg Ala Leu His
165 170 175

Ala Tyr Arg Lys Val Ala Pro Arg Ala Leu Arg Arg Ala Ala Met Ala
180 185 190

Thr Ala Gly Arg Trp Ile Val Glu Arg Gln Glu Asn Asp Gly Cys Trp
195 200 205

Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Met Ile Ala Leu His Leu
210 215 220

Leu Gly Tyr Asp Leu Gly His Pro Val Met Arg Ala Gly Leu Glu Ser
225 230 235 240

Leu Asp Arg Phe Thr Leu Thr Arg Glu Asp Gly Ser Arg Met Val Glu
245 250 255

Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu
260 265 270

Ala Asp Ala Gly Val Pro Ala Asp His Pro Gln Leu Val Arg Ala Ala
275 280 285

Asp Trp Met Leu Asp Glu Gln Ile Glu Arg Pro Gly Asp Trp Ser Val
290 295 300

Arg Arg Pro His Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe His Asn
305 310 315 320

Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu
325 330 335

Arg Arg Val Arg His Pro Asp Thr Ala Arg Met Glu Arg Ala Ile Ser
340 345 350

Leu Gly Val Arg Trp Asn Leu Gly Met Gln Ser Lys Asn Gly Ala Trp
355 360 365

Gly Ala Phe Asp Val Asp Asn Thr Ser Ser Leu Pro Asn Arg Leu Pro
370 375 380

Phe Cys Asp Phe Gly Glu Val Val Asp Pro Pro Ser Ala Asp Val Thr
385 390 395 400

Ala His Val Val Glu Met Leu Ala Ala Glu Gly Leu Ala Ala Asp Pro
405 410 415

Arg Thr Arg Arg Ala Val Asp Trp Leu Leu Ala Glu Gln Glu Pro Ser
420 425 430

Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Gly
435 440 445

Ser Ala Val Pro Ala Leu Val Asp Ala Gly Leu Pro Thr Thr His Pro
450 455 460

Ala Ile Arg Arg Ala Val Ala Trp Leu Glu Ser Val Gln Asn Asp Asp
465 470 475 480

Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Arg Glu Gln Gly Arg Met
485 490 495

Ala Arg Gly Ala Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Met Ala
500 505 510

Leu Leu Ala Ala Gly Glu Arg Glu Ser Arg Ala Ala Arg Arg Gly Val
515 520 525

Thr Phe Leu Ala Glu Thr Gln His Glu Asp Gly Ser Trp Glu Glu Pro
530 535 540

Tyr Tyr Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His
545 550 555 560

Leu Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Thr Arg
565 570 575

Gly Ala Ala Pro Glu Gly Ala
580


<210> 221
<211> 666
<212> PRT
<213> Streptomyces avermitilis

<400> 221
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Leu Pro Pro Arg Ala
1 5 10 15

Ala Ser Ala Ser Glu Pro His Asp Thr Ile Pro Gln Ala Ala Gly Ser
20 25 30

Val Gly Ile Gln Asp Ala Ala Ala Arg Ala Thr Gln Arg Ala Thr Asp
35 40 45

Phe Leu Leu Ser Arg Gln Asp Ala Glu Gly Trp Trp Lys Gly Asp Leu
50 55 60

Glu Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe
65 70 75 80

Leu Gly Ile Gln Asp Glu Lys Thr Thr Arg Ala Ala Gly Leu Phe Ile
85 90 95

Arg Gly Glu Gln Arg Ala Asp Gly Thr Trp Ala Thr Phe Tyr Gly Gly
100 105 110

Pro Gly Asp Leu Ser Ala Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu
115 120 125

Ala Gly Asp Gly Pro Asp Glu Pro His Met Ala Lys Ala Ser Ala Trp
130 135 140

Ile Arg Glu Arg Gly Gly Ile Ala Ser Ala Arg Val Phe Thr Arg Ile
145 150 155 160

Trp Leu Ala Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro Glu Leu
165 170 175

Pro Pro Glu Leu Ile Tyr Phe Pro Lys Trp Met Pro Leu Asn Ile Tyr
180 185 190

Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Val Val
195 200 205

Ser Ala Lys Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu Leu
210 215 220

His Ala Asp Ala Asn Asp Pro Asn Pro Ala Lys Pro Leu Ala Pro Met
225 230 235 240

Val Ser Trp Asp Gly Leu Phe Gln Arg Leu Asp Val Ala Leu His Thr
245 250 255

Tyr Arg Lys Val Ala Pro Arg Arg Leu Arg Lys Ala Ala Met Asn Thr
260 265 270

Ala Ala Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly
275 280 285

Gly Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu Tyr Leu Leu
290 295 300

Gly Tyr Asp Leu Glu His Pro Val Met Arg Glu Gly Leu Ala Ser Leu
305 310 315 320

Asp Arg Phe Ala Val Trp Arg Asp Asp Gly Ala Arg Met Ile Glu Ala
325 330 335

Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala
340 345 350

Asp Ala Gly Val Pro Ala Asp His Pro Gln Leu Val Arg Ala Ala Asp
355 360 365

Trp Met Leu Gly Glu Glu Ile Val Arg Pro Gly Asp Trp Ala Val Lys
370 375 380

Arg Pro Gln Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp
385 390 395 400

Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg
405 410 415

Arg Val Lys His His Asp Pro Glu Arg Leu Asp Asn Ala Ile Arg Arg
420 425 430

Gly Val Arg Trp Asn Leu Gly Met Gln Ser Lys Asp Gly Gly Trp Gly
435 440 445

Ala Phe Asp Val Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe
450 455 460

Cys Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala
465 470 475 480

His Val Val Glu Met Leu Ala Phe Glu Gly Leu Ser His Asp Pro Arg
485 490 495

Thr Arg Arg Gly Ile Gln Trp Leu Leu Ser Ala Gln Glu Ala Asn Gly
500 505 510

Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser
515 520 525

Val Val Pro Ala Leu Val Ala Ala Gly Leu Pro Ala Ser His Pro Ala
530 535 540

Ile Arg Arg Ala Val Thr Trp Leu Glu Thr Val Gln Asn Asp Asp Gly
545 550 555 560

Gly Trp Gly Glu Asp Leu Arg Ser Tyr Pro Glu Ala Ala Glu Trp Ser
565 570 575

Gly Lys Gly Ala Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Leu Ala
580 585 590

Leu Leu Ala Ala Gly Glu Arg Glu Ser Lys Ala Val Glu Arg Gly Ile
595 600 605

Glu Trp Leu Ala Gln Thr Gln Arg Pro Asp Gly Ser Trp Asp Glu Pro
610 615 620

Tyr Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His
625 630 635 640

Leu Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val Asn
645 650 655

Gly Glu Pro Leu Val Glu Val Lys Gly Gly
660 665


<210> 222
<211> 639
<212> PRT
<213> Acaryochloris marina

<400> 222
Met Ala Val Arg Asp Arg Val Asn Pro Lys Thr Leu Glu Ala Ala Ile
1 5 10 15

Ala Ala Ser Gln Ser Tyr Leu Leu Thr Gln Gln Asp Glu Thr Gly Tyr
20 25 30

Trp Trp Ala Glu Leu Glu Ser Asn Val Ser Ile Thr Ser Glu Val Val
35 40 45

Leu Leu His Lys Ile Trp Gly Thr Asp Arg Ser Arg Pro Leu Glu Lys
50 55 60

Val Glu Thr Tyr Leu Arg Ser Gln Gln Arg Asp His Gly Gly Trp Glu
65 70 75 80

Leu Tyr Phe Asp Asp Gly Gly Glu Ile Ser Val Ser Val Glu Ala Tyr
85 90 95

Met Ala Leu Lys Leu Leu Gly Val Pro Met Glu Asp Pro Ala Met Val
100 105 110

Arg Ala Arg Gln Phe Ile Leu Glu His Gly Gly Ile Ser Arg Thr Arg
115 120 125

Val Phe Thr Lys Leu His Leu Ala Leu Ile Gly Cys Tyr Glu Trp Arg
130 135 140

Gly Ile Pro Ser Leu Pro Pro Trp Val Met Leu Leu Pro Glu Gln Phe
145 150 155 160

Pro Phe Thr Ile Tyr Glu Met Ser Ser Trp Ala Arg Gly Ser Thr Val
165 170 175

Pro Leu Leu Ile Val Met Asp Arg Glu Pro Val Tyr Ala Val Glu Ala
180 185 190

Gly Phe Asn Leu Asp Glu Leu Tyr Val Glu Gly Arg His Arg Ala Gln
195 200 205

Phe Asp Leu Pro Leu Ser Asn Glu Trp Thr Asp Ala Phe Ile Tyr Leu
210 215 220

Asp Gly Leu Phe Lys Phe Ala Glu Ser Thr Asn Leu Val Pro Phe Arg
225 230 235 240

Glu Glu Gly Ile Arg Ala Ala Glu Arg Trp Ile Leu Glu Arg Gln Glu
245 250 255

Ala Thr Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn Ser Leu
260 265 270

Leu Gly Leu Lys Ala Leu Asp Tyr Asp Val His Asp Pro Ile Ile Glu
275 280 285

Arg Gly Met Ala Ala Leu Asp Ala Phe Ala Leu Glu Thr Glu Asp Gln
290 295 300

Tyr Trp Ile Gln Pro Cys Ile Ser Pro Val Trp Asp Thr Ala Leu Val
305 310 315 320

Val Arg Gly Leu Ala Glu Ser Gly Leu Ala Pro Asp His Pro Ala Leu
325 330 335

Val Lys Ala Gly Glu Trp Leu Leu Asn Lys Gln Ile Leu Asp Tyr Gly
340 345 350

Asp Trp Ser Val Lys Asn Pro Gly Gly Leu Pro Gly Gly Trp Ala Phe
355 360 365

Glu Phe Asp Asn Arg Phe Tyr Pro Asp Val Asp Asp Thr Ala Val Val
370 375 380

Val Met Ala Leu Asn Glu Val Gln Leu Pro Asp Glu Gln Ala Lys Asp
385 390 395 400

Ala Ala Ile Ala Arg Ala Val Asn Trp Ile Ala Thr Met Gln Cys Arg
405 410 415

Pro Gly Gly Trp Ala Ala Phe Asp Ile Asn Asn Asp Gln Asp Trp Leu
420 425 430

Asn Ala Leu Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp Pro Asn Thr
435 440 445

Ala Asp Val Thr Ala Arg Val Leu Glu Met Ile Gly Arg Cys His Gln
450 455 460

Thr Thr Gly Lys Asn Ser Val Asp Arg Ala Leu Arg Tyr Leu Arg Thr
465 470 475 480

Glu Gln Glu Pro Glu Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr
485 490 495

Ile Tyr Gly Thr Ser Gly Val Leu Ala Ala Leu Ala Leu Ile Asp Pro
500 505 510

Gln Gly Trp Gln Ser Gln Ile Gln Gln Ala Ala Ala Trp Leu Val Ser
515 520 525

Cys Gln Asn Thr Asp Gly Gly Trp Gly Glu Thr Cys Ala Ser Tyr Asp
530 535 540

Asn Pro Lys Leu Lys Gly Gln Gly Pro Ser Thr Ala Ser Gln Thr Ala
545 550 555 560

Trp Ala Ile Met Gly Leu Leu Ser Ala Gly Glu Ala Thr Ser Val Tyr
565 570 575

Ala Glu Ala Ala Ile Glu Arg Gly Val Asn Tyr Leu Thr Thr Thr Gln
580 585 590

Lys Met Asp Gly Thr Trp Asp Glu Asp Tyr Phe Thr Gly Thr Gly Phe
595 600 605

Pro Gly His Phe Tyr Leu Lys Tyr His Leu Tyr Gln Gln His Phe Pro
610 615 620

Leu Thr Ala Leu Gly Arg Tyr Gln Ala Met Leu Gln Gln Lys Ser
625 630 635


<210> 223
<211> 666
<212> PRT
<213> Streptomyces filamentosus

<400> 223
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Ala Asn Ile Thr Gly
1 5 10 15

Ala Pro Ala Asp Asp Pro Thr Asp Thr Arg Thr Ala Ala Asn Asp Val
20 25 30

Thr Asp Ile Ala Arg Arg Ala Ala Glu Arg Ser Val Glu His Leu Leu
35 40 45

Gly Arg Gln Asp Glu Gln Gly Trp Trp Lys Gly Asp Leu Ala Thr Asn
50 55 60

Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Gly Ile
65 70 75 80

Gln Asp Pro Ala Thr Thr Arg Ala Ala Ala Leu Phe Ile Arg Gly Glu
85 90 95

Gln Leu Gly Asp Gly Thr Trp Asn Thr Phe Tyr Gly Gly Pro Gly Asp
100 105 110

Leu Ser Ala Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly Asp
115 120 125

Arg Pro Asp Glu Pro His Met Ala Arg Ala Ser Gly Trp Ile Arg Asp
130 135 140

Gln Gly Gly Ile Ala Ala Ala Arg Val Phe Thr Arg Ile Trp Leu Ala
145 150 155 160

Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro Glu Leu Pro Pro Glu
165 170 175

Leu Met Phe Phe Pro Lys Trp Val Pro Leu Asn Ile Tyr Asp Phe Gly
180 185 190

Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser Ala Lys
195 200 205

Arg Pro Val Arg Pro Ala Pro Phe Ala Leu Asp Glu Leu His Thr Asp
210 215 220

Pro Asp His Pro Asn Pro Pro Arg Lys Leu Ala Pro Pro Thr Ser Trp
225 230 235 240

Asp Gly Leu Phe Gln Arg Leu Asp Lys Gly Leu His Leu Tyr His Lys
245 250 255

Val Ala Pro Arg Pro Leu Arg Arg Ile Ala Met Asn Val Ala Ala Arg
260 265 270

Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile Gln
275 280 285

Pro Pro Ala Val Tyr Ser Val Ile Ala Leu His Leu Leu Gly Tyr Asp
290 295 300

Leu Asp His Pro Val Met Lys Ala Gly Leu Ala Ser Leu Asp Arg Phe
305 310 315 320

Ala Val His Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys Gln Ser
325 330 335

Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp Ala Gly
340 345 350

Leu Arg Pro Asp His Pro Ala Leu Val Lys Ala Ala Asp Trp Met Leu
355 360 365

Ala Glu Glu Ile Thr Arg Pro Gly Asp Trp Ser Val Arg Lys Pro Glu
370 375 380

Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn Tyr Pro
385 390 395 400

Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg Val Arg
405 410 415

His Pro Asp Pro Ala Arg Leu Glu Ala Ala Ile Ala Arg Gly Val Arg
420 425 430

Trp Asn Leu Gly Met Gln Ser Arg Asn Gly Ala Trp Gly Ala Phe Asp
435 440 445

Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe Cys Asp Phe
450 455 460

Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Gly His Val Val
465 470 475 480

Glu Met Leu Ala Val Glu Gly Leu Ala Asn His Pro Arg Thr Arg Glu
485 490 495

Gly Ile Glu Trp Leu Leu Ala Glu Gln Glu Ala Cys Gly Ala Trp Phe
500 505 510

Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser Val Val Pro
515 520 525

Ala Leu Ile Thr Ala Gly Leu Pro Ala Gly His Pro Ala Ile Arg Arg
530 535 540

Ala Val Asp Trp Leu Glu Ser Val Gln Asn Asp Asp Gly Gly Trp Gly
545 550 555 560

Glu Asp Leu Arg Ser Tyr Gln Glu Glu Lys Trp Ile Gly His Gly Glu
565 570 575

Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala Ala
580 585 590

Gly Arg Arg Asp Thr Ala Ser Val Thr Arg Gly Val Thr Trp Leu Thr
595 600 605

Glu Ala Gln Gln Ala Asp Gly Ser Trp Asp Glu Pro Tyr Phe Thr Gly
610 615 620

Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr Arg Gln
625 630 635 640

Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val His Gly Asp Pro Phe
645 650 655

Ala Asp Arg Thr Asp Ala Ala Glu Gly Val
660 665


<210> 224
<211> 670
<212> PRT
<213> Streptomyces flavogriseus

<400> 224
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Ala Asn Leu Arg Ala
1 5 10 15

Ala Ala Ala Ser Asp Pro Thr Glu Ser Thr Ser Ala Ala Pro Asp Met
20 25 30

Met Ala Val Ala Arg His Ala Ala Glu Arg Ser Val Glu His Leu Leu
35 40 45

Gly Arg Gln Asp Glu Gln Gly Trp Trp Lys Gly Asp Leu Ala Thr Asn
50 55 60

Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Gly Ile
65 70 75 80

Gln Asp Pro Glu Thr Val Lys Ala Ala Ala Arg Phe Ile Arg Gly Glu
85 90 95

Gln Leu Gly Asp Gly Thr Trp Asn Thr Phe Tyr Glu Gly Pro Pro Asp
100 105 110

Leu Ser Ala Thr Val Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly Asp
115 120 125

Arg Pro Asp Asp Pro His Met Ile Arg Ala Ala Gly Trp Val Arg Glu
130 135 140

Gln Gly Gly Ile Ala Glu Ser Arg Val Phe Thr Arg Ile Trp Leu Ala
145 150 155 160

Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro Glu Leu Pro Pro Glu
165 170 175

Leu Met Phe Phe Pro Lys Trp Val Pro Leu Asn Ile Tyr Asp Phe Gly
180 185 190

Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser Ala Lys
195 200 205

Arg Pro Val Arg Pro Ala Pro Phe Ala Leu Asp Glu Leu His Thr Asp
210 215 220

Pro Ala Cys Pro Asn Pro Ser Arg Pro Thr Ala Pro Ala Ala Ser Trp
225 230 235 240

Asp Gly Val Phe Gln Arg Leu Asp Lys Ala Leu His Leu Tyr His Lys
245 250 255

Val Ala Pro Arg Arg Leu Arg Arg Ile Ala Met Asn Glu Ala Ala Arg
260 265 270

Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile Gln
275 280 285

Pro Pro Ala Val Tyr Ser Val Ile Ala Leu His Leu Leu Gly Tyr Asp
290 295 300

Leu Asp His Pro Val Met Arg Ala Gly Leu Glu Ser Leu Asp Arg Phe
305 310 315 320

Ala Val Trp Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys Gln Ser
325 330 335

Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp Ala Gly
340 345 350

Val Ser Pro Asp His Pro Ala Leu Val Arg Ala Ala Asp Trp Met Leu
355 360 365

Gly Glu Glu Ile Val Arg Pro Gly Asp Trp Ala Val Arg Lys Pro Gly
370 375 380

Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe His Asn Val Asn Tyr Pro
385 390 395 400

Asp Ile Asp Asp Thr Ala Glu Val Ala Leu Ala Leu Arg Arg Val Arg
405 410 415

His Pro Asp Pro Ala Arg Val Asp Ala Ala Ile Glu Arg Gly Val Arg
420 425 430

Trp Asn Leu Gly Met Gln Ser Arg Asn Gly Ala Trp Gly Ala Phe Asp
435 440 445

Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe Cys Asp Phe
450 455 460

Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Gly His Val Val
465 470 475 480

Glu Met Leu Ala Val Glu Gly Arg Ala His Asp Pro Arg Thr Arg Arg
485 490 495

Gly Val Glu Trp Leu Leu Ala Glu Gln Glu Ala Ser Gly Ala Trp Phe
500 505 510

Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Gly Ser Val Val Pro
515 520 525

Ala Leu Ile Ala Ala Gly Leu Pro Ala Ala His Pro Ser Val Arg Arg
530 535 540

Ala Val Asp Trp Leu Arg Ser Val Gln Asn Asp Asp Gly Gly Trp Gly
545 550 555 560

Glu Asp Leu Arg Ser Tyr Arg Glu Glu Lys Trp Ile Gly His Gly Ser
565 570 575

Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Leu Ala Leu Leu Ala Ala
580 585 590

Gly Glu Arg Glu Thr Arg Ser Val Glu Arg Gly Val Ala Trp Leu Ala
595 600 605

Ala Thr Gln Gln Ala Asp Gly Ser Trp Asp Glu Pro His Phe Thr Gly
610 615 620

Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr Arg Gln
625 630 635 640

Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val Tyr Gly Asp Pro Phe
645 650 655

Ala Thr Ala Thr Ala Ile Gly Ala Gly Thr Gly Lys Gly Ala
660 665 670


<210> 225
<211> 686
<212> PRT
<213> Streptomyces ghanaensis

<400> 225
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Ala Leu Pro Pro Arg
1 5 10 15

Val Thr Ala Ala Ser Asp Thr Asp Thr Asp Ile Pro Val Ala Ala Gly
20 25 30

Val Pro Asp Ile Ala Ala Arg Ala Met Arg Arg Ala Thr Asp Phe Leu
35 40 45

Leu Ser Arg Gln Ser Asp Gln Gly Trp Trp Lys Gly Asp Leu Glu Thr
50 55 60

Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Gly
65 70 75 80

Ile Arg Asp Glu Gly Thr Thr Arg Ala Ala Ala Leu Phe Ile Arg Gly
85 90 95

Glu Gln Arg Glu Asp Gly Thr Trp Ala Thr Phe His Gly Gly Pro Gly
100 105 110

Asp Leu Ser Ala Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly
115 120 125

Asp Pro Pro Asp Ala Pro His Leu Ala Arg Ala Ser Ala Trp Ile Arg
130 135 140

Glu Gln Gly Gly Ile Ala Ala Ser Arg Val Phe Thr Arg Ile Trp Leu
145 150 155 160

Ala Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu Pro Glu Leu Pro Pro
165 170 175

Glu Leu Ile Trp Phe Pro Ala Trp Val Pro Leu Asn Ile Tyr Asp Phe
180 185 190

Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser Ala
195 200 205

Glu Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu Leu His Thr
210 215 220

Asp Pro Ala Arg Pro Asn Pro Pro Arg Ala Leu Ala Pro Val Thr Gly
225 230 235 240

Trp Asp Gly Ala Phe Gln Arg Leu Asp Lys Ala Leu His Val Leu Arg
245 250 255

Gly Ala Val Pro Arg Arg Leu Arg Arg Ala Ala Met Asn Thr Ala Ala
260 265 270

Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile
275 280 285

Gln Pro Pro Ala Val Tyr Ser Ile Ile Ala Leu His Leu Leu Gly Tyr
290 295 300

Asp Leu Asn His Pro Val Met Arg Ala Gly Leu Glu Ser Leu Asp Arg
305 310 315 320

Phe Ala Val Trp Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys Gln
325 330 335

Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp Ala
340 345 350

Gly Leu Pro Ala Asp His Pro Gln Leu Val Lys Ala Ala Asp Trp Met
355 360 365

Leu Gly Glu Gln Ile Val Arg Pro Gly Asp Trp Ser Val Arg Arg Pro
370 375 380

His Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn Tyr
385 390 395 400

Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg Val
405 410 415

Ala His His Asp Pro Glu Arg Val Asp Asn Ala Ile Gly Arg Gly Val
420 425 430

Arg Trp Asn Leu Gly Met Gln Ser Arg Asn Gly Ala Trp Gly Ala Phe
435 440 445

Asp Val Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe Cys Asp
450 455 460

Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His Val
465 470 475 480

Val Glu Met Leu Ala Ala Glu Gly Leu Ala His Asp Pro Arg Thr Arg
485 490 495

Arg Gly Val Gln Trp Leu Leu Ala Glu Gln Glu Pro Asn Gly Ser Trp
500 505 510

Phe Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Gly Ser Val Val
515 520 525

Pro Ala Leu Thr Ala Ala Gly Ile Ser Gly Ser His Pro Ala Ile Arg
530 535 540

Arg Ala Val Ala Trp Leu Glu Ser Val Gln Asn Asp Asp Gly Gly Trp
545 550 555 560

Gly Glu Asp Leu Arg Ser Tyr Arg Asp Ala Arg Gly Trp Ser Gly Arg
565 570 575

Gly Ala Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Ala Leu Leu
580 585 590

Ala Ala Gly Glu Arg Glu Ser Arg Ala Val Glu Arg Gly Val Glu Trp
595 600 605

Leu Ala Ala Thr Gln His Glu Asp Gly Ser Trp Asp Glu Pro Tyr Phe
610 615 620

Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr
625 630 635 640

Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val Asn Gly Glu
645 650 655

Pro Leu Ala Gly Lys Pro Arg Ala Ala Gly Ala Ala Thr Ala Arg Glu
660 665 670

Asp Thr Gly Gln Glu Gln Ser Leu Ala Glu Ala Lys Gly Ser
675 680 685


<210> 226
<211> 680
<212> PRT
<213> Streptomyces griseoflavus

<400> 226
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Ala Leu Pro Pro Arg
1 5 10 15

Val Thr Ala Ala Ser Glu Asn Asp Thr Asp Ile Pro Glu Ala Ala Gly
20 25 30

Val Pro Asp Ile Ala Ala His Ala Met Arg Arg Ala Thr Asp Phe Leu
35 40 45

Leu Ser Arg Gln Asp Asp Gln Gly Trp Trp Lys Gly Asp Leu Glu Thr
50 55 60

Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Gly
65 70 75 80

Ile Arg Asp Glu Asp Thr Thr Arg Ala Ala Ala Leu Phe Ile Arg Gly
85 90 95

Glu Gln Arg Glu Asp Gly Thr Trp Ala Thr Phe His Gly Gly Pro Gly
100 105 110

Glu Leu Ser Thr Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly
115 120 125

Asp Pro Pro Glu Ala Pro His Met Ala Arg Ala Ser Ala Trp Ile Arg
130 135 140

Glu Arg Gly Gly Ile Ala Ala Ala Arg Val Phe Thr Arg Ile Trp Leu
145 150 155 160

Ala Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu Pro Glu Leu Pro Pro
165 170 175

Glu Leu Ile Trp Phe Pro Ser Trp Val Pro Leu Asn Ile Tyr Asp Phe
180 185 190

Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser Ala
195 200 205

Lys Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu Leu His Thr
210 215 220

Asp Pro Arg Arg Pro Arg Pro Pro Arg Pro His Ala Pro Pro Asn Thr
225 230 235 240

Trp Asp Gly Ala Phe Gln Arg Leu Asp Arg Ala Leu His Ala Leu Arg
245 250 255

Arg Ala Val Pro Arg Arg Val Arg Gln Ala Ala Met Asn Ala Ala Ala
260 265 270

Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile
275 280 285

Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu His Leu Leu Gly Tyr
290 295 300

Asp Leu Arg His Pro Val Met Arg Ala Gly Leu Glu Ser Leu Asp Arg
305 310 315 320

Phe Ala Val Trp Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys Gln
325 330 335

Ser Pro Val Trp Asp Thr Cys Leu Ala Ala Ile Ala Leu Ala Asp Ala
340 345 350

Gly Leu Pro Ala Asp His Pro Ser Leu Val Lys Ala Ala Asp Trp Met
355 360 365

Leu Gly Glu Gln Ile Val Arg Pro Gly Asp Trp Ser Val Arg Arg Pro
370 375 380

His Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn Tyr
385 390 395 400

Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg Val
405 410 415

Arg His His Asp Pro Glu Arg Met Asp Ser Ala Ile Gly Arg Gly Val
420 425 430

Arg Trp Ser Leu Gly Met Gln Ser Lys Asn Gly Ala Trp Gly Ala Phe
435 440 445

Asp Val Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe Cys Asp
450 455 460

Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His Val
465 470 475 480

Val Glu Met Leu Ala Val Glu Gly Leu Ala His Asp Pro Arg Thr Arg
485 490 495

Arg Gly Ile Gln Trp Leu Leu Ala Glu Gln Glu Pro Asp Gly Ser Trp
500 505 510

Phe Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Gly Ser Val Val
515 520 525

Pro Ala Leu Ala Ala Ala Gly Ile Pro Gly Ser His Pro Ala Ile Arg
530 535 540

Arg Ala Val Ala Trp Leu Glu Lys Val Gln Asn Asp Asp Gly Gly Trp
545 550 555 560

Gly Glu Asp Leu Arg Ser Tyr Arg His Val Arg Glu Trp Ser Gly Arg
565 570 575

Gly Ala Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Ala Leu Leu
580 585 590

Ala Ala Gly Glu Arg Asp Ser Gly Ala Val Glu Arg Gly Val Ala Trp
595 600 605

Leu Ala Ala Thr Gln Arg Glu Asp Gly Ser Trp Asp Glu Pro Tyr Phe
610 615 620

Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr
625 630 635 640

Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val His Gly Glu
645 650 655

Pro Phe Ser Lys Lys Gln Thr Ala Ala Arg Asn Gly Ser Ala Gln Pro
660 665 670

Leu Ala Gly Val Lys Gly Ser Arg
675 680


<210> 227
<211> 666
<212> PRT
<213> Streptomyces griseus

<400> 227
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Ala Asn Pro Ser Glu
1 5 10 15

Ala Thr Ala His Asp Pro Thr Asp Thr Thr Thr Ala Ala Asp Asp Leu
20 25 30

Thr Val Ala Ala Arg Arg Ala Ala Glu Arg Ser Val Glu His Leu Leu
35 40 45

Gly Arg Gln Asp Glu Gln Gly Trp Trp Lys Gly Asp Leu Ala Thr Asn
50 55 60

Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Ser Ile
65 70 75 80

Gln Asp Pro Glu Thr Thr Arg Ala Ala Ala Leu Phe Ile Arg Gly Glu
85 90 95

Gln Leu Gly Asp Gly Thr Trp Asn Thr Phe Tyr Gly Gly Pro Gly Asp
100 105 110

Leu Ser Ala Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly Asp
115 120 125

Arg Pro Asp Glu Pro His Met Ala Arg Ala Ala Gly Trp Ile Arg Asp
130 135 140

Gln Gly Gly Ile Ala Ala Ala Arg Val Phe Thr Arg Ile Trp Leu Ala
145 150 155 160

Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro Glu Leu Pro Pro Glu
165 170 175

Leu Met Phe Phe Pro Lys Trp Val Pro Leu Asn Ile Tyr Asp Phe Gly
180 185 190

Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser Ala Lys
195 200 205

Arg Pro Val Arg Pro Ala Pro Phe Ala Leu Asp Glu Leu His Thr Asp
210 215 220

Pro Asp His Pro Asn Pro Pro Arg Lys Leu Ala Pro Pro Thr Ser Trp
225 230 235 240

Asp Gly Leu Phe Gln Arg Leu Asp Lys Gly Leu His Leu Tyr His Lys
245 250 255

Val Ala Pro Arg Pro Leu Arg Arg Val Ala Met Asn Leu Ala Ala Arg
260 265 270

Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile Gln
275 280 285

Pro Pro Ala Val Tyr Ser Val Ile Ala Leu His Leu Leu Gly Tyr Asp
290 295 300

Leu Asp His Pro Val Met Lys Ala Gly Leu Ala Ser Leu Asp Arg Phe
305 310 315 320

Ala Val Arg Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys Gln Ser
325 330 335

Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp Ala Gly
340 345 350

Leu Arg Pro Asp His Pro Ala Leu Val Lys Ala Ala Asp Trp Met Leu
355 360 365

Ala Glu Glu Ile Thr Arg Pro Gly Asp Trp Ser Val Arg Lys Pro Glu
370 375 380

Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn Tyr Pro
385 390 395 400

Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg Val Arg
405 410 415

His Pro Asp Pro Ala Arg Leu Gln Ala Ala Ile Asp Arg Gly Val Arg
420 425 430

Trp Asn Leu Gly Met Gln Ser Arg Asn Gly Ala Trp Gly Ala Phe Asp
435 440 445

Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe Cys Asp Phe
450 455 460

Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Gly His Val Val
465 470 475 480

Glu Met Leu Ala Val Glu Gly Leu Ala Ser His Pro Arg Thr Arg Glu
485 490 495

Gly Ile Glu Trp Leu Leu Ala Glu Gln Glu Ala Cys Gly Ala Trp Phe
500 505 510

Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser Val Val Pro
515 520 525

Ala Leu Ile Thr Ala Gly Leu Pro Ala Gly His Pro Ala Ile Arg Arg
530 535 540

Ala Val Ala Trp Leu Glu Ser Val Gln Asn Asp Asp Gly Gly Trp Gly
545 550 555 560

Glu Asp Leu Arg Ser Tyr Gln Glu Glu Lys Trp Ile Gly His Gly Glu
565 570 575

Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala Ala
580 585 590

Gly Arg Arg Asp Thr Arg Pro Val Ala Arg Gly Val Thr Trp Leu Thr
595 600 605

Glu Ala Gln Gln Ala Asp Gly Ser Trp Asp Glu Pro Tyr Phe Thr Gly
610 615 620

Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr Arg Gln
625 630 635 640

Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val His Gly Asp Pro Phe
645 650 655

Ala Asp Arg Ala Met Ala Ala Glu Gly Ala
660 665


<210> 228
<211> 630
<212> PRT
<213> Streptomyces hygroscopicus

<400> 228
Met Leu Ala Arg Arg Ala Thr Asp Arg Ala Val Arg His Leu Leu Ser
1 5 10 15

Arg Gln Asp Glu Gln Gly Trp Trp Lys Gly Asp Leu Glu Thr Asn Val
20 25 30

Thr Met Asp Ala Glu Asp Leu Met Leu Arg His Phe Leu Gly Ile Gln
35 40 45

Asn Pro Asp Val Leu Asp Ala Ala Gly Arg Tyr Ile Arg Ser Gln Gln
50 55 60

Ala Ala Asp Gly Thr Trp Ala Thr Phe His Gly Gly Pro Pro Glu Leu
65 70 75 80

Ser Ala Thr Val Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly Asp Pro
85 90 95

Pro Asp Ala Pro His Met Ala Ala Ala Ser Ala Trp Val Arg Asn Asn
100 105 110

Gly Gly Val Ala Ser Ser Arg Val Phe Thr Arg Ile Trp Leu Ala Leu
115 120 125

Phe Gly Trp Trp Arg Trp Glu Asp Leu Pro Glu Leu Pro Pro Glu Ile
130 135 140

Ile Tyr Phe Pro Pro Trp Leu Pro Leu Asn Leu Tyr Asp Phe Gly Cys
145 150 155 160

Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Val Val Ser Ala Lys Arg
165 170 175

Pro Val Arg Pro Ala Pro Phe Ser Leu Asp Glu Leu His Ala Asp Pro
180 185 190

Arg Arg Pro Asn Pro Pro Arg Pro Ala Ala Pro Leu Ala Ser Trp Asp
195 200 205

Gly Ala Phe Gln Arg Leu Asp Arg Ala Leu His Leu Tyr Arg Lys Val
210 215 220

Ala Leu Arg Pro Leu Arg Arg Ala Ala Leu Arg Ser Cys Ala Arg Trp
225 230 235 240

Ile Val Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile Gln Pro
245 250 255

Pro Ala Val Tyr Ser Val Ile Ala Leu His Leu Leu Gly Tyr Asp Leu
260 265 270

Asp His Pro Val Met Arg Ala Gly Leu Glu Ser Leu Asp Arg Phe Ala
275 280 285

Val Trp Arg Glu Asp Gly Ser Arg Met Ile Glu Ala Cys Gln Ser Pro
290 295 300

Val Trp Asp Thr Cys Leu Ala Val Ile Ala Leu Ala Asp Ala Gly Leu
305 310 315 320

Ala Pro Asp His Pro Ala Leu Val Lys Ser Ala Asp Trp Met Leu Ala
325 330 335

Glu Glu Ile Asp Arg Pro Gly Asp Trp Ser Val Lys Arg Pro Arg Leu
340 345 350

Ala Pro Gly Gly Trp Ala Phe Glu Phe Asp Asn Asp Asn Tyr Pro Asp
355 360 365

Ile Asp Asp Thr Ala Glu Val Ile Leu Ala Leu Arg Arg Val Asp His
370 375 380

Pro Arg Pro Glu Arg Ile Ala Ala Ala Val Arg Arg Gly Val Arg Trp
385 390 395 400

Thr Leu Gly Met Gln Ser Arg Asn Gly Ala Trp Gly Ala Phe Asp Val
405 410 415

Asp Asn Thr Ser Pro Leu Pro Asn Arg Leu Pro Phe Cys Asp Phe Gly
420 425 430

Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His Val Val Glu
435 440 445

Met Leu Ala His Glu Gly Gly Ala Arg Asp Pro Arg Thr Arg Arg Ala
450 455 460

Val Gly Trp Leu Leu Ala Glu Gln Glu Pro Ser Gly Ala Trp Phe Gly
465 470 475 480

Arg Trp Gly Thr Asn Tyr Val Tyr Gly Thr Gly Ser Val Val Pro Ala
485 490 495

Leu Val Ala Ala Gly Leu Pro Ala Thr His Pro Ala Ile Arg Arg Ala
500 505 510

Val Arg Trp Leu Glu Ser Val Gln Asn Glu Asp Gly Gly Trp Gly Glu
515 520 525

Asp Gln Arg Ser Tyr Pro Asp Pro Glu Trp Ile Gly His Gly Ala Ser
530 535 540

Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala Ala Gly
545 550 555 560

Glu Arg Glu Ser Lys Ala Val Glu Arg Gly Val Gly Trp Leu Ala Ala
565 570 575

Thr Gln Asp Gln Asp Gly Ser Trp Asp Glu Pro Tyr Phe Thr Gly Thr
580 585 590

Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr Arg Leu Val
595 600 605

Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val Ser Gly Glu Ala Thr Gly
610 615 620

Ala Arg Pro Arg Arg Thr
625 630


<210> 229
<211> 680
<212> PRT
<213> Streptomyces lividans

<400> 229
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Ser Leu Arg Pro Leu
1 5 10 15

Ala Ala Ser Ala Ser Asp Thr Asp Ile Thr Ile Pro Ala Ala Ala Ala
20 25 30

Gly Val Pro Glu Ala Ala Ala Arg Ala Thr Arg Arg Ala Thr Asp Phe
35 40 45

Leu Leu Ala Lys Gln Asp Ala Glu Gly Trp Trp Lys Gly Asp Leu Glu
50 55 60

Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu
65 70 75 80

Gly Ile Gln Asp Glu Glu Thr Thr Arg Ala Ala Ala Leu Phe Ile Arg
85 90 95

Gly Glu Gln Arg Glu Asp Gly Thr Trp Ala Thr Phe Tyr Gly Gly Pro
100 105 110

Gly Glu Leu Ser Thr Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu Ala
115 120 125

Gly Asp Ser Pro Glu Ala Pro His Met Ala Arg Ala Ala Glu Trp Ile
130 135 140

Arg Ser Arg Gly Gly Ile Ala Ser Ala Arg Val Phe Thr Arg Ile Trp
145 150 155 160

Leu Ala Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro Glu Leu Pro
165 170 175

Pro Glu Leu Ile Tyr Phe Pro Thr Trp Val Pro Leu Asn Ile Tyr Asp
180 185 190

Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser
195 200 205

Ala Lys Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu Leu His
210 215 220

Thr Asp Pro Ala Arg Pro Asn Pro Pro Arg Pro Leu Ala Pro Val Ala
225 230 235 240

Ser Trp Asp Gly Ala Phe Gln Arg Ile Asp Lys Ala Leu His Ala Tyr
245 250 255

Arg Lys Val Ala Pro Arg Arg Leu Arg Arg Ala Ala Met Asn Ser Ala
260 265 270

Ala Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly
275 280 285

Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu Tyr Leu Leu Gly
290 295 300

Tyr Asp Leu Glu His Pro Val Met Arg Ala Gly Leu Glu Ser Leu Asp
305 310 315 320

Arg Phe Ala Val Trp Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys
325 330 335

Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp
340 345 350

Ala Gly Val Pro Glu Asp His Pro Gln Leu Val Lys Ala Ser Asp Trp
355 360 365

Met Leu Gly Glu Gln Ile Val Arg Pro Gly Asp Trp Ser Val Lys Arg
370 375 380

Pro Gly Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn
385 390 395 400

Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg
405 410 415

Val Arg His His Asp Pro Glu Arg Val Glu Lys Ala Ile Gly Arg Gly
420 425 430

Val Arg Trp Asn Leu Gly Met Gln Ser Lys Asn Gly Ala Trp Gly Ala
435 440 445

Phe Asp Val Asp Asn Thr Ser Ala Phe Pro Asn Arg Leu Pro Phe Cys
450 455 460

Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His
465 470 475 480

Val Val Glu Met Leu Ala Val Glu Gly Leu Ala His Asp Pro Arg Thr
485 490 495

Arg Arg Gly Ile Gln Trp Leu Leu Asp Ala Gln Glu Ala Asp Gly Ser
500 505 510

Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser Val
515 520 525

Ile Pro Ala Leu Thr Ala Ala Gly Leu Pro Thr Ser His Pro Ala Ile
530 535 540

Arg Arg Ala Val Arg Trp Leu Glu Ser Val Gln Asn Glu Asp Gly Gly
545 550 555 560

Trp Gly Glu Asp Leu Arg Ser Tyr Arg Tyr Val Arg Glu Trp Ser Gly
565 570 575

Arg Gly Ala Ser Thr Ala Ser Gln Thr Gly Trp Ala Leu Met Ala Leu
580 585 590

Leu Ala Ala Gly Glu Arg Asp Ser Lys Ala Val Glu Arg Gly Val Ala
595 600 605

Trp Leu Ala Ala Thr Gln Arg Glu Asp Gly Ser Trp Asp Glu Pro Tyr
610 615 620

Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr Asn Leu
625 630 635 640

Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val His Gly
645 650 655

Glu Pro Phe Ala Lys Lys Ser Arg Ala Ala Asp Ala Pro Ala Glu Ala
660 665 670

Ala Pro Ala Glu Val Lys Gly Ser
675 680


<210> 230
<211> 674
<212> PRT
<213> Streptomyces peucetius

<400> 230
Met Thr Ala Thr Thr Asp Gly Ser Ser Gly Pro Leu Arg Gly Gly Ala
1 5 10 15

Ala Thr Ala Gly Glu Thr Thr Ser Thr Ser Ala Ala Arg Thr Thr Glu
20 25 30

Pro Gly Thr Asp Leu Arg Glu Ala Ala Ala Arg Ala Ala Glu Arg Ala
35 40 45

Val Glu His Leu Leu Ala Arg Gln Asp Ala Glu Gly Trp Trp Lys Gly
50 55 60

Asp Leu Glu Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg
65 70 75 80

Gln Phe Leu Gly Ile Gln Asp Pro Ala Thr Val Gly Ala Ser Ala Arg
85 90 95

Phe Ile Arg Gly Gln Gln Arg Asp Asp Gly Thr Trp Ala Thr Phe Tyr
100 105 110

Gly Gly Pro Gly Glu Leu Ser Thr Thr Val Glu Ala Tyr Val Ala Leu
115 120 125

Arg Leu Ala Gly Asp Arg Pro Asp Asp Pro His Met Gln Arg Ala Ala
130 135 140

Ser Trp Val Arg Ser Arg Gly Gly Ile Ala Ala Ser Arg Val Phe Thr
145 150 155 160

Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu Pro
165 170 175

Glu Leu Pro Pro Glu Leu Ile Phe Leu Pro Lys Trp Phe Pro Leu Asn
180 185 190

Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr
195 200 205

Val Val Ser Ala Lys Arg Pro Val Arg Pro Ala Pro Phe Ala Leu Asp
210 215 220

Glu Leu His Thr Asp Pro Ala Leu Pro Asn Pro Gly Lys Arg Leu Ala
225 230 235 240

Pro Ala Ala Ser Trp Asp Gly Phe Phe Gln Arg Ala Asp Lys Ala Leu
245 250 255

His Ala Tyr His Lys Val Ala Pro Arg Arg Leu Arg Arg Ala Ala Met
260 265 270

Asn Ala Ala Ala Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys
275 280 285

Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu His
290 295 300

Leu Leu Gly Tyr Asp Leu Glu His Pro Val Met Arg Ala Gly Leu Glu
305 310 315 320

Ser Leu Asp Arg Phe Ala Val His His Glu Glu Glu Gly Leu Pro Val
325 330 335

Arg Met Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala
340 345 350

Thr Ile Ala Leu Ala Asp Ala Gly Leu Pro Ala Asp His Pro Ala Leu
355 360 365

Val Lys Ala Ala Asp Trp Met Leu Ser Glu Gln Ile Val Arg Pro Gly
370 375 380

Asp Trp Ser Val Arg Arg Pro Gly Leu Gly Pro Gly Gly Trp Ala Phe
385 390 395 400

Glu Phe His Asn Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val
405 410 415

Val Leu Ala Leu Arg Arg Val Lys His Pro Asp Pro Glu Arg Val Asp
420 425 430

Ala Ala Val Ala Arg Gly Thr Arg Trp Asn Leu Gly Met Gln Ser Arg
435 440 445

Asp Gly Ala Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro
450 455 460

Asn Arg Leu Pro Phe Cys Asp Phe Gly Glu Val Ile Asp Pro Pro Ser
465 470 475 480

Ala Asp Val Thr Ala His Val Val Glu Ile Leu Ala His Glu Gly Met
485 490 495

Ala His Asp Pro Arg Thr Arg Arg Gly Val Arg Trp Leu Leu Ala His
500 505 510

Gln Glu Ala Asn Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Val
515 520 525

Tyr Gly Thr Gly Ala Val Val Pro Ala Leu Thr Ala Ala Gly Leu Pro
530 535 540

Gly Ser His Pro Ala Ile Arg Arg Ala Val Ala Trp Leu Glu Ser Val
545 550 555 560

Gln Asn Glu Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Arg Glu
565 570 575

Glu Lys Ser Ile Gly Arg Gly Val Ser Thr Ala Ser Gln Thr Gly Trp
580 585 590

Ala Leu Leu Ala Leu Leu Ala Ala Gly Glu Arg Glu Ser Lys Ala Val
595 600 605

Glu Arg Gly Val Ala His Leu Ala Gln Thr Gln Ala Pro Asp Gly Ser
610 615 620

Trp Asp Glu Pro Tyr Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser
625 630 635 640

Ile Asn Tyr His Leu Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly
645 650 655

Arg Tyr Val His Gly Glu Lys Leu Pro Gly Arg Ala Gly Ala Arg Glu
660 665 670

Gly Arg


<210> 231
<211> 674
<212> PRT
<213> Streptomyces pristinaespiralis

<400> 231
Met Thr Ala Thr Thr Asp Gly Ser Ser Gly Pro Val Arg Ala Gly Ala
1 5 10 15

Ala Thr Ala Gly Asp Thr Thr Thr Thr Thr Ala Ala Arg Thr Thr Ala
20 25 30

Pro Gly Thr Asp Val Arg Glu Ala Ala Gly Arg Ala Ala Glu Arg Ala
35 40 45

Val Glu His Leu Leu Ala Arg Gln Asp Ala Gln Gly Trp Trp Lys Gly
50 55 60

Asp Leu Glu Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg
65 70 75 80

Gln Phe Leu Gly Ile Gln Asp Ala Ala Thr Val Glu Ala Ser Ala Arg
85 90 95

Phe Ile Arg Gly Gln Gln Arg Asp Asp Gly Thr Trp Ala Thr Phe Tyr
100 105 110

Gly Gly Pro Gly Glu Leu Ser Thr Thr Ile Glu Ala Tyr Val Ala Leu
115 120 125

Arg Leu Ala Gly Asp Arg Pro Asp Asp Pro His Met Gln Arg Ala Ala
130 135 140

Ser Trp Val Arg Ser Arg Gly Gly Ile Ala Ala Ala Arg Val Phe Thr
145 150 155 160

Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro
165 170 175

Glu Leu Pro Pro Glu Leu Ile Leu Leu Pro Lys Trp Val Pro Leu Asn
180 185 190

Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr
195 200 205

Val Val Ser Ala Lys Arg Pro Val Arg Pro Ala Pro Phe Ala Leu Asp
210 215 220

Glu Leu His Thr Asp Pro Ala Met Pro Asn Pro Gln Lys Arg Phe Ala
225 230 235 240

Pro Ala Ala Ser Trp Asp Gly Phe Phe Gln Arg Ala Asp Lys Ala Leu
245 250 255

His Leu Tyr His Lys Val Ala Pro Arg Arg Leu Arg Arg Ala Ala Met
260 265 270

Asn Ala Ala Ala Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys
275 280 285

Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu His
290 295 300

Leu Leu Gly Tyr Asp Leu Glu His Pro Val Met Arg Ala Gly Leu Glu
305 310 315 320

Ser Leu Asp Arg Phe Ala Val His Arg Glu Glu Glu Gly Leu Pro Val
325 330 335

Arg Met Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala
340 345 350

Thr Ile Ala Leu Ala Asp Ala Gly Leu Pro Ala Asp His Pro Ala Leu
355 360 365

Val Lys Ala Ala Asp Trp Met Leu Ser Glu Gln Ile Val Arg Pro Gly
370 375 380

Asp Trp Ala Val Arg Arg Pro Gly Leu Gly Pro Gly Gly Trp Ala Phe
385 390 395 400

Glu Phe His Asn Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val
405 410 415

Ile Leu Ala Leu Arg Arg Val Lys His Pro Asp Pro Glu Arg Val Glu
420 425 430

Ala Ala Val Ala Arg Gly Thr Arg Trp Asn Leu Gly Met Gln Ser Leu
435 440 445

Asn Gly Ala Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro
450 455 460

Asn Arg Leu Pro Phe Cys Asp Phe Gly Glu Val Ile Asp Pro Pro Ser
465 470 475 480

Ala Asp Val Thr Ala His Val Val Glu Met Leu Ala His Glu Gly Met
485 490 495

Ala Glu Asp Pro Arg Thr Arg Arg Gly Val Arg Trp Leu Leu Arg Glu
500 505 510

Gln Glu Ala Asn Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Val
515 520 525

Tyr Gly Thr Gly Ala Val Val Pro Ala Leu Ile Ala Ala Gly Leu Pro
530 535 540

Ala Ser His Pro Ser Val Arg Arg Ala Val Thr Trp Leu Glu Ser Val
545 550 555 560

Gln Asn Glu Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Arg Glu
565 570 575

Glu Gln Ser Ile Gly Arg Gly Ala Ser Thr Ala Ser Gln Thr Gly Trp
580 585 590

Ala Leu Leu Ala Leu Leu Ser Ala Gly Glu Arg Asp Gly Arg Ala Val
595 600 605

Glu Arg Gly Val Ala Trp Leu Ala Arg Thr Gln Arg Pro Asp Gly Ser
610 615 620

Trp Asp Glu Pro Tyr Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser
625 630 635 640

Ile Asn Tyr His Leu Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly
645 650 655

Arg Phe Leu His Gly Glu Lys Pro Val Gly Arg Ala Ala Ala Arg Glu
660 665 670

Gly Gly


<210> 232
<211> 664
<212> PRT
<213> Streptomyces scabiei

<400> 232
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Leu Pro Pro Arg Ala
1 5 10 15

Pro Ser Ala Ser Asp Thr Asp His Gly Thr Pro Val Ala Ala Gly Val
20 25 30

Gln Glu Ala Ala Leu His Ala Val Gly Arg Ala Thr Asp Phe Leu Leu
35 40 45

Ser Arg Gln Asp Ala Gln Gly Trp Trp Lys Gly Asp Leu Glu Thr Asn
50 55 60

Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg Gln Phe Leu Gly Ile
65 70 75 80

Arg Asp Asp Ala Thr Thr Arg Ala Ala Ala Leu Phe Ile Arg Gly Glu
85 90 95

Gln Arg Pro Asp Gly Thr Trp Ala Thr Phe Tyr Gly Gly Pro Pro Asp
100 105 110

Leu Ser Ala Thr Val Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly Asp
115 120 125

Asp Pro Ala Ala Pro His Met Ala Lys Ala Ser Ala Trp Ile Arg Ala
130 135 140

Arg Gly Gly Ile Ala Ala Ala Arg Val Phe Thr Arg Ile Trp Leu Ala
145 150 155 160

Leu Phe Gly Trp Trp Lys Trp Asp Asp Leu Pro Glu Met Pro Pro Glu
165 170 175

Ile Val Tyr Phe Pro Thr Trp Met Pro Leu Asn Ile Tyr Asp Phe Gly
180 185 190

Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Val Val Ser Ala Lys
195 200 205

Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu Leu His Thr Asp
210 215 220

Pro Gly Arg Pro Asn Pro Pro Arg Pro Leu Asp Arg Leu Gly Ser Trp
225 230 235 240

Glu Gly Ala Phe Gln Arg Leu Asp Arg Ala Leu His Gly Tyr His Lys
245 250 255

Val Ala Leu Lys Arg Leu Arg Arg Ala Ala Met Asn Arg Ala Ala Arg
260 265 270

Trp Ile Val Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile Gln
275 280 285

Pro Pro Ala Val Tyr Ser Val Ile Ala Leu His Leu Leu Gly Tyr Asp
290 295 300

Leu Gly His Pro Val Met Arg Ala Gly Leu Glu Ser Leu Asp Arg Phe
305 310 315 320

Ala Val Trp Arg Glu Asp Gly Ala Arg Met Ile Glu Ala Cys Gln Ser
325 330 335

Pro Val Trp Asp Thr Cys Leu Ala Thr Ile Ala Leu Ala Asp Ala Gly
340 345 350

Leu Pro Pro Asp His Pro Gln Leu Val Lys Ala Ala Asp Trp Met Leu
355 360 365

Gly Glu Glu Ile Val Arg Pro Gly Asp Trp Ser Val Lys Arg Pro Gln
370 375 380

Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn Tyr Pro
385 390 395 400

Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg Val Arg
405 410 415

His Pro Asp Pro Glu Arg Val Glu Arg Ala Val Arg Arg Gly Val Arg
420 425 430

Trp Thr Leu Gly Met Gln Ser Gly Asn Gly Ala Trp Ala Ala Phe Asp
435 440 445

Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe Cys Asp Phe
450 455 460

Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His Val Val
465 470 475 480

Glu Met Leu Ala Ala Glu Gly Leu Ser His Asp Pro Arg Thr Arg Arg
485 490 495

Gly Ile Glu Trp Leu Leu Ala Glu Gln Glu Pro Gly Gly Ala Trp Phe
500 505 510

Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser Val Val Pro
515 520 525

Ala Leu Val Thr Ala Gly Leu Pro Ala Ala His Pro Ala Ile Arg Arg
530 535 540

Ala Val Ala Trp Leu Glu Thr Val Gln Asn Asp Asp Gly Gly Trp Gly
545 550 555 560

Glu Asp Leu Arg Ser Tyr Pro Asp Pro Ala Glu Trp Gly Gly Lys Gly
565 570 575

Ala Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala
580 585 590

Ala Gly Glu Arg Asp Gly Lys Ala Thr Glu Arg Gly Val Ala Trp Leu
595 600 605

Ala Arg Thr Gln Arg Glu Asp Gly Ser Trp Asp Glu Pro Tyr Phe Thr
610 615 620

Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr Arg
625 630 635 640

Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val His Gly Glu Pro
645 650 655

Ala Val Leu Lys Pro Gly Thr Arg
660


<210> 233
<211> 684
<212> PRT
<213> Streptomyces sp.

<400> 233
Met Arg Arg Arg Arg Ser Pro Arg Gly Pro Gly Ala Gly Pro Glu Ala
1 5 10 15

Asp Tyr Gly Pro Ala Arg Ala Ser Ala Pro Asp Arg Leu Arg Gly Asp
20 25 30

Ala Ala Arg Gly Asp Ala Ala Arg Arg Val Gln Asp Ala Thr Ala Arg
35 40 45

Ala Ile Arg Asn Leu Leu Gly Arg Gln Asp Pro Ala Gly Trp Trp Lys
50 55 60

Gly Asp Leu Glu Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu
65 70 75 80

Arg Gln Phe Leu Gly Ile Arg Asp Glu Ala Val Thr Gln Ala Ala Ala
85 90 95

Leu Phe Ile Arg Arg Glu Gln Arg Glu Asp Gly Thr Trp Ala Thr Phe
100 105 110

His Gly Gly Pro Pro Glu Leu Ser Ala Thr Ile Glu Ala Tyr Val Ala
115 120 125

Leu Arg Leu Ala Gly Asp Ala Pro Asp Ala Pro His Met Ala Thr Ala
130 135 140

Ser Ala Trp Ile Arg Ala His Gly Gly Leu Ala Ala Ala Arg Val Phe
145 150 155 160

Thr Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Asp Trp Glu Asn Leu
165 170 175

Pro Glu Leu Pro Pro Glu Leu Val Leu Leu Pro Pro Trp Val Pro Leu
180 185 190

Asn Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu
195 200 205

Thr Val Val Ser Ala Met Arg Pro Val Arg Pro Ala Pro Phe Ala Leu
210 215 220

Asp Glu Leu His Thr Asp Ala Arg Val Pro Val Pro Pro Arg Arg Met
225 230 235 240

Ala Pro Pro Thr Thr Trp Asn Gly Ala Phe Gln Trp Met Asp Arg Ala
245 250 255

Leu His Val Tyr Arg Arg Phe Ala Pro Arg Arg Leu Arg Glu Ala Ala
260 265 270

Met Ala Ser Ala Gly Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly
275 280 285

Cys Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu
290 295 300

His Leu Leu Gly Tyr Asp Leu Gly His Pro Val Met Arg Ala Gly Leu
305 310 315 320

Glu Ser Leu Asp Arg Phe Ala Val Trp Arg Glu Asp Gly Ser Arg Met
325 330 335

Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Ala Ile
340 345 350

Ala Leu Ala Asp Ala Gly Val Arg Pro Asp His Pro Ala Leu Val Lys
355 360 365

Ala Ala Asp Trp Met Leu Gly Glu Glu Ile Val Arg Thr Gly Asp Trp
370 375 380

Ala Val Arg Arg Pro Gly Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe
385 390 395 400

His Asn Asp Thr Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu
405 410 415

Ala Leu Arg Arg Ile Arg His Pro Asp Pro Ala Arg Val Glu Ala Ala
420 425 430

Ile Ala Arg Gly Val Ser Trp Asn Leu Gly Met Gln Ser Arg Gly Gly
435 440 445

Ala Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg
450 455 460

Leu Pro Phe Cys Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp
465 470 475 480

Val Thr Ala His Val Val Glu Met Leu Ala Ala Glu Gly Arg Ala Ala
485 490 495

Asp Pro Arg Thr Arg Arg Gly Ile Ala Trp Leu Leu Ala Glu Gln Glu
500 505 510

Pro Glu Gly Pro Trp Phe Gly Arg Trp Gly Thr Asn Tyr Val Tyr Gly
515 520 525

Thr Gly Ser Val Val Pro Ala Leu Thr Ala Ala Gly Leu Ser Pro Gly
530 535 540

His Pro Ala Ile Arg Arg Ala Val Leu Trp Leu Glu Ser Val Gln Asn
545 550 555 560

Pro Asp Gly Gly Trp Gly Glu Asp Gln Arg Ser Tyr Gln Asp Arg Ala
565 570 575

Trp Ala Gly Lys Gly Glu Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu
580 585 590

Met Ala Leu Leu Ser Ala Gly Glu Arg Asp Ala Lys Thr Val Glu Arg
595 600 605

Gly Ile Ala Tyr Leu Val Glu Thr Gln Leu Ala Asp Gly Gly Trp Asp
610 615 620

Glu Pro His Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn
625 630 635 640

Tyr His Leu Tyr Arg His Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr
645 650 655

Leu Tyr Gly Glu Pro Phe Gly His Asp Gly Arg His Ile Gly Ala His
660 665 670

Leu Gly Asp Arg Thr Gly Val Pro Ala Glu Gly Val
675 680


<210> 234
<211> 665
<212> PRT
<213> Streptomyces sp.

<400> 234
Met His Glu Gly Glu Ala Met Thr Ala Thr Thr Asp Gly Ser Thr Gly
1 5 10 15

Ala Ala Thr Pro Pro Ala Thr Thr Ala Ser Ala Pro Leu His Leu Ser
20 25 30

Pro Glu Ala Arg Glu Thr His Glu Ala Thr Ala Arg Ala Thr Arg Arg
35 40 45

Ala Val Asp Phe Leu Leu Ala Arg Gln Ser Asp Glu Gly Trp Trp Lys
50 55 60

Gly Asp Leu Ala Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu
65 70 75 80

Arg Gln Phe Leu Gly Ile Arg Asp Glu Ala Thr Thr Arg Ala Ala Ala
85 90 95

Leu Phe Ile Arg Gly Glu Gln Gln Glu Asp Gly Thr Trp Asn Thr Phe
100 105 110

Tyr Gly Gly Pro Gly Asp Leu Ser Ala Thr Ile Glu Gly Tyr Val Ala
115 120 125

Leu Arg Leu Ala Gly Asp Ser Pro Glu Ala Pro His Met Arg Lys Ala
130 135 140

Ser Ala Phe Val Arg Ala Gln Gly Gly Val Ala Arg Ala Arg Val Phe
145 150 155 160

Thr Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu
165 170 175

Pro Glu Met Pro Pro Glu Leu Met Phe Phe Pro Lys Trp Ala Pro Leu
180 185 190

Asn Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu
195 200 205

Thr Val Val Cys Ala Gln Arg Pro Val Arg Pro Ala Pro Phe Ala Leu
210 215 220

Glu Glu Leu His Thr Asp Pro Ala Asp Pro Asp Pro Ala Gln Pro Ala
225 230 235 240

Pro Pro Val Val Ser Trp Asp Asn Val Phe His Lys Leu Asp Lys Leu
245 250 255

Leu His Gly Tyr Arg Arg Ile Ala Pro Arg Arg Val Arg Glu Ala Ala
260 265 270

Met Arg Ala Ala Ala Thr Trp Ile Val Glu Arg Gln Glu Asn Asp Gly
275 280 285

Cys Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Ile Met Ala Leu
290 295 300

Asn Leu Leu Gly Tyr Asp Leu Asp His Pro Val Leu Arg Ala Gly Leu
305 310 315 320

Ala Ser Leu Asp Arg Phe Ala Val Trp Arg Glu Asp Gly Ala Arg Met
325 330 335

Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Val
340 345 350

Ala Leu Ala Asp Ala Gly Val Pro Ala Asp His Pro Gln Met Ile Lys
355 360 365

Ala Ala Asp Trp Met Leu Ala Glu Gln Ile Val Arg Pro Gly Asp Trp
370 375 380

Val Val Arg Arg Pro Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe
385 390 395 400

His Asn Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu
405 410 415

Ala Leu Arg Arg Val Ala His Pro Asp Ala Thr Arg Val Asp Lys Ala
420 425 430

Val Arg Arg Ala Val Asp Trp Asn Val Gly Met Gln Ser Lys Asn Gly
435 440 445

Ala Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg
450 455 460

Leu Pro Phe Ser Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp
465 470 475 480

Val Thr Ala His Val Val Glu Met Leu Ala Glu Glu Gly Leu Ala His
485 490 495

His Pro Arg Thr Arg Arg Gly Ile Glu Trp Leu Leu Lys Asn Gln Glu
500 505 510

Gly Asn Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly
515 520 525

Thr Gly Ala Val Val Pro Ala Leu Val Ala Ala Gly Leu Pro Ala Ser
530 535 540

His Pro Ala Ile Arg Arg Ser Val Ser Trp Leu Gly Gln Val Gln Asn
545 550 555 560

Glu Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Gln Asp Ser Ala
565 570 575

Trp His Gly Arg Gly His Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu
580 585 590

Leu Ala Leu Leu Ala Ala Gly Glu Arg Glu Thr Glu Gln Val Arg Arg
595 600 605

Gly Ile Ala Tyr Leu Val Glu Thr Gln Thr Glu Asp Gly Thr Trp Asp
610 615 620

Glu Pro Trp Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Thr Ile Asn
625 630 635 640

Tyr His Leu Tyr Arg Gln Val Phe Pro Val Thr Ala Leu Gly Arg Tyr
645 650 655

Leu Asn Gly Thr Gly Pro Gly Glu Asn
660 665


<210> 235
<211> 636
<212> PRT
<213> Streptomyces sp. AA4

<400> 235
Met Thr Gln Thr Val Pro Arg Thr Ala Ala Ser Ala Pro Ala Ala Arg
1 5 10 15

Thr Ala Ala Asp Thr Val Ala Ala Ala Val Gln Phe Leu Arg Arg Glu
20 25 30

Gln Asp Arg Ala Gly Trp Trp Lys Gly Glu Leu Ala Thr Asn Val Thr
35 40 45

Met Asp Ala Glu Asp Leu Leu Leu Arg His Phe Leu Gly Ile Leu Thr
50 55 60

Pro Gln Ile Ala Glu Glu Ser Ala Arg Trp Ile Arg Ser Gln Gln Arg
65 70 75 80

Ala Asp Gly Thr Trp Ala Asn Phe Pro Asp Gly Pro Ala Asp Leu Ser
85 90 95

Thr Thr Val Glu Ala Trp Val Ala Leu Arg Leu Ala Gly Asp Pro Ala
100 105 110

Asp Ala Pro Trp Leu Ala Thr Ala Ala Glu Trp Ile Arg Glu His Gly
115 120 125

Gly Ile Glu Ala Thr Arg Val Phe Thr Arg Ile Trp Leu Ala Met Val
130 135 140

Gly Gln Trp Ser Trp Asp Asp Leu Pro Ser Leu Pro Pro Glu Leu Ile
145 150 155 160

Phe Leu Pro Ser Trp Phe Pro Leu Asn Val Tyr Asp Phe Ala Cys Trp
165 170 175

Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Gly Thr Leu Arg Pro
180 185 190

Ala Arg Lys Leu Pro Phe Asp Val Ala Glu Leu Arg Thr Gly Lys Arg
195 200 205

Pro Pro Lys Pro Arg Ala Pro Trp Thr Trp Asp Gly Val Phe Gln Asn
210 215 220

Leu Asp Thr Ala Leu His Ala Tyr Ala Lys Leu Pro Leu Asn Pro Val
225 230 235 240

Arg Lys Leu Ala Leu Lys Gln Ala Ala Glu Trp Ile Leu Ala Arg Gln
245 250 255

Glu Ala Asp Gly Ser Trp Gly Gly Ile Gln Pro Pro Trp Val Tyr Ser
260 265 270

Ile Leu Ala Leu His Leu Leu Gly Tyr Ser Leu Asp His Pro Ala Leu
275 280 285

Lys Ala Gly Ile Ala Gly Leu Asp Gly Phe Thr Ile Arg Glu Lys Thr
290 295 300

Asp Gln Gly Trp Val Arg Arg Leu Glu Ala Cys Gln Ser Pro Val Trp
305 310 315 320

Asp Thr Ala Leu Ala Met Thr Ala Leu Leu Asp Ala Gly Val Ser Pro
325 330 335

Gly Asp Glu Ser Leu Val Arg Ala Ala Glu Trp Met Leu Gly Glu Glu
340 345 350

Ile Arg Val Pro Gly Asp Trp Ala Val Arg Arg Pro Ser Leu Lys Pro
355 360 365

Gly Gly Phe Ala Phe Glu Phe Ala Asn Asp Gly Tyr Pro Asp Thr Asp
370 375 380

Asp Thr Ala Glu Val Val Leu Ala Leu Arg Arg Met Gly Lys Pro Asp
385 390 395 400

His Leu Arg Ile Arg Glu Ala Val Asp Arg Ser Val Ala Trp Leu Glu
405 410 415

Gly Met Gln Ser Ser Asp Gly Gly Trp Gly Ala Phe Asp Ala Asp Asn
420 425 430

Thr Gln Val Leu Thr Thr Arg Leu Pro Phe Cys Asp Phe Gly Ala Val
435 440 445

Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His Val Val Glu Met Leu
450 455 460

Ala Ala Glu Gly Lys Ala Asp Thr Arg Glu Cys Arg Arg Gly Ile Arg
465 470 475 480

Trp Leu Trp Asp Asn Gln Glu Ala Asp Gly Ser Trp Phe Gly Arg Trp
485 490 495

Gly Ala Asn Tyr Val Tyr Gly Thr Gly Ala Val Val Pro Ala Leu Val
500 505 510

Ala Ala Gly Val Pro Gly Thr Asp Pro Arg Ile Arg Arg Ala Val Arg
515 520 525

Trp Leu Ala Glu His Gln Asn Asp Asp Gly Gly Trp Gly Glu Asp Leu
530 535 540

Arg Ser Tyr Asp Asp Arg Ser Trp Ala Gly Arg Gly Asp Ser Thr Pro
545 550 555 560

Ser Gln Thr Ala Trp Ala Leu Leu Ala Leu Leu Ala Ala Gly Glu Arg
565 570 575

Glu Ser Thr Val Val Ala Arg Gly Val Glu Trp Leu Cys Glu Arg Gln
580 585 590

Arg Pro Asp Gly Gly Trp Asp Glu Asp Lys His Thr Gly Thr Gly Phe
595 600 605

Pro Gly Asp Phe Tyr Leu Ser Tyr His Leu Tyr Arg Val Val Phe Pro
610 615 620

Leu Ser Ala Leu Gly Arg Tyr Val Arg Gly Gly Ser
625 630 635


<210> 236
<211> 676
<212> PRT
<213> Streptomyces sp. C

<400> 236
Met Thr Ala Thr Thr Asp Gly Gly Gly Ala Ile Thr Gly Gly Ala Asp
1 5 10 15

Pro Arg His Asp Ser Thr Ala Ala Pro Ala Ala Ala Ala Ala Gly Pro
20 25 30

Ser Gly Gly Gly Thr Gly Leu Pro Glu Gly Val Arg Glu Ala Val Asp
35 40 45

Arg Ala Thr Ala Glu Leu Leu Ala Arg Gln Asp Pro Ala Gly Trp Trp
50 55 60

Lys Gly Asp Leu Gln Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu
65 70 75 80

Leu Arg Gln Phe Leu Gly Ile Arg Asp Glu Ala Val Thr Arg Ala Ala
85 90 95

Ala Leu Phe Ile Arg Gly Glu Gln Gln Gly Asp Gly Thr Trp Ala Thr
100 105 110

Phe His Gly Gly Pro Pro Glu Leu Ser Ala Thr Ile Glu Ala Tyr Val
115 120 125

Ala Leu Arg Leu Ala Gly Asp Pro Pro Asp Ala Pro His Met Thr Arg
130 135 140

Ala Ser Ala Trp Ile Arg Ala His Gly Gly Ile Ala Ala Ala Arg Val
145 150 155 160

Phe Thr Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Ser Trp Asp Arg
165 170 175

Leu Pro Glu Leu Pro Pro Glu Leu Val Phe Leu Pro Pro Trp Val Pro
180 185 190

Leu Asn Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro
195 200 205

Leu Thr Val Val Ser Ala Leu Arg Pro Val Arg Ser Ala Pro Phe Ala
210 215 220

Leu Asp Glu Leu His Thr Asp Ala Arg Asp Pro Val Pro Ala Lys Pro
225 230 235 240

Leu Pro Pro Leu Ala Ser Trp Asp Gly Ala Phe Gln Arg Met Asp Lys
245 250 255

Ala Leu His Leu Tyr Arg Arg Val Ala Pro Arg Arg Leu Arg Lys Ala
260 265 270

Ala Met Ala Ala Ala Gly Arg Trp Ile Val Glu Arg Gln Glu Asn Asp
275 280 285

Gly Cys Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala
290 295 300

Leu His Leu Leu Gly Tyr Asp Leu Gly His Pro Val Met Arg Ala Gly
305 310 315 320

Leu Glu Ser Leu Asp Arg Phe Ala Val Trp Arg Glu Asp Gly Ala Arg
325 330 335

Met Val Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Ala
340 345 350

Ile Ala Leu Ala Asp Ala Gly Leu Pro Pro Asp His Pro Ala Leu Val
355 360 365

Arg Ala Ala Asp Trp Met Leu Gly Glu Glu Ile Arg Arg Pro Gly Asp
370 375 380

Trp Ala Val Arg Arg Pro Gly Leu Ala Pro Gly Gly Trp Ala Phe Glu
385 390 395 400

Phe His Asn Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val
405 410 415

Leu Ala Leu Arg Arg Ile Arg His Pro Gln Pro Gly Gly Val Glu Ala
420 425 430

Ala Ile Ala Arg Gly Val Ser Trp Thr Leu Gly Met Gln Ser Lys Asn
435 440 445

Gly Ala Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro Asn
450 455 460

Arg Leu Pro Phe Cys Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala
465 470 475 480

Asp Val Thr Ala His Val Val Glu Met Leu Ala Ala Glu Gly Arg Ala
485 490 495

Ala Asp Pro Arg Ala Arg Arg Gly Ile Ala Trp Leu Leu Ala Glu Gln
500 505 510

Glu Pro Asp Gly Pro Trp Phe Gly Arg Trp Gly Thr Asn Tyr Val Tyr
515 520 525

Gly Thr Gly Ser Val Val Pro Ala Leu Thr Ala Ala Gly Ile Ala Pro
530 535 540

Ser His Pro Ala Val Arg Arg Ala Val Arg Trp Leu Glu Ser Val Gln
545 550 555 560

Asn Glu Asp Gly Gly Trp Gly Glu Asp Gln Arg Ser Tyr Arg Asp Arg
565 570 575

Ser Trp Ala Gly Lys Gly Ala Ser Thr Ala Ser Gln Thr Ala Trp Ala
580 585 590

Leu Met Ala Leu Leu Ser Ala Gly Glu Arg Asp Gly Asp Ala Val Ala
595 600 605

Arg Gly Leu Ala Tyr Leu Val Glu Thr Gln Arg Pro Asp Gly Thr Trp
610 615 620

Asp Glu Pro Tyr Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile
625 630 635 640

Asn Tyr His Leu Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg
645 650 655

Tyr Leu His Gly Glu Pro Phe Gly Pro Glu Arg Arg Asn Val Pro Pro
660 665 670

Ala Gly Glu Ser
675


<210> 237
<211> 684
<212> PRT
<213> Streptomyces sp. Mg1

<400> 237
Met Arg Arg Arg Arg Ser Pro Arg Gly Pro Gly Ala Gly Pro Glu Ala
1 5 10 15

Asp Tyr Gly Pro Ala Arg Ala Ser Ala Pro Asp Arg Leu Arg Gly Asp
20 25 30

Ala Ala Arg Gly Asp Ala Ala Arg Arg Val Gln Asp Ala Thr Ala Arg
35 40 45

Ala Ile Arg Asn Leu Leu Gly Arg Gln Asp Pro Ala Gly Trp Trp Lys
50 55 60

Gly Asp Leu Glu Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu
65 70 75 80

Arg Gln Phe Leu Gly Ile Arg Asp Glu Ala Val Thr Gln Ala Ala Ala
85 90 95

Leu Phe Ile Arg Arg Glu Gln Arg Glu Asp Gly Thr Trp Ala Thr Phe
100 105 110

His Gly Gly Pro Pro Glu Leu Ser Ala Thr Ile Glu Ala Tyr Val Ala
115 120 125

Leu Arg Leu Ala Gly Asp Ala Pro Asp Ala Pro His Met Ala Thr Ala
130 135 140

Ser Ala Trp Ile Arg Ala His Gly Gly Leu Ala Ala Ala Arg Val Phe
145 150 155 160

Thr Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Asp Trp Glu Asn Leu
165 170 175

Pro Glu Leu Pro Pro Glu Leu Val Leu Leu Pro Pro Trp Val Pro Leu
180 185 190

Asn Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu
195 200 205

Thr Val Val Ser Ala Met Arg Pro Val Arg Pro Ala Pro Phe Ala Leu
210 215 220

Asp Glu Leu His Thr Asp Ala Arg Val Pro Val Pro Pro Arg Arg Met
225 230 235 240

Ala Pro Pro Thr Thr Trp Asn Gly Ala Phe Gln Trp Met Asp Arg Ala
245 250 255

Leu His Val Tyr Arg Arg Phe Ala Pro Arg Arg Leu Arg Glu Ala Ala
260 265 270

Met Ala Ser Ala Gly Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly
275 280 285

Cys Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu
290 295 300

His Leu Leu Gly Tyr Asp Leu Gly His Pro Val Met Arg Ala Gly Leu
305 310 315 320

Glu Ser Leu Asp Arg Phe Ala Val Trp Arg Glu Asp Gly Ser Arg Met
325 330 335

Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Ala Ile
340 345 350

Ala Leu Ala Asp Ala Gly Val Arg Pro Asp His Pro Ala Leu Val Lys
355 360 365

Ala Ala Asp Trp Met Leu Gly Glu Glu Ile Val Arg Thr Gly Asp Trp
370 375 380

Ala Val Arg Arg Pro Gly Leu Ala Pro Gly Gly Trp Ala Phe Glu Phe
385 390 395 400

His Asn Asp Thr Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu
405 410 415

Ala Leu Arg Arg Ile Arg His Pro Asp Pro Ala Arg Val Glu Ala Ala
420 425 430

Ile Ala Arg Gly Val Ser Trp Asn Leu Gly Met Gln Ser Arg Gly Gly
435 440 445

Ala Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg
450 455 460

Leu Pro Phe Cys Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp
465 470 475 480

Val Thr Ala His Val Val Glu Met Leu Ala Ala Glu Gly Arg Ala Ala
485 490 495

Asp Pro Arg Thr Arg Arg Gly Ile Ala Trp Leu Leu Ala Glu Gln Glu
500 505 510

Pro Glu Gly Pro Trp Phe Gly Arg Trp Gly Thr Asn Tyr Val Tyr Gly
515 520 525

Thr Gly Ser Val Val Pro Ala Leu Thr Ala Ala Gly Leu Ser Pro Gly
530 535 540

His Pro Ala Ile Arg Arg Ala Val Leu Trp Leu Glu Ser Val Gln Asn
545 550 555 560

Pro Asp Gly Gly Trp Gly Glu Asp Gln Arg Ser Tyr Gln Asp Arg Ala
565 570 575

Trp Ala Gly Lys Gly Glu Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu
580 585 590

Met Ala Leu Leu Ser Ala Gly Glu Arg Asp Ala Lys Thr Val Glu Arg
595 600 605

Gly Ile Ala Tyr Leu Val Glu Thr Gln Leu Ala Asp Gly Gly Trp Asp
610 615 620

Glu Pro His Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn
625 630 635 640

Tyr His Leu Tyr Arg His Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr
645 650 655

Leu Tyr Gly Glu Pro Phe Gly His Asp Gly Arg His Ile Gly Ala His
660 665 670

Leu Gly Asp Arg Thr Gly Val Pro Ala Glu Gly Val
675 680


<210> 238
<211> 665
<212> PRT
<213> Streptomyces sp. SPB74

<400> 238
Met His Glu Gly Glu Ala Met Thr Ala Thr Thr Asp Gly Ser Thr Gly
1 5 10 15

Ala Ala Thr Pro Pro Ala Thr Thr Ala Ser Ala Pro Leu His Leu Ser
20 25 30

Pro Glu Ala Arg Glu Thr His Glu Ala Thr Ala Arg Ala Thr Arg Arg
35 40 45

Ala Val Asp Phe Leu Leu Ala Arg Gln Ser Asp Glu Gly Trp Trp Lys
50 55 60

Gly Asp Leu Ala Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu
65 70 75 80

Arg Gln Phe Leu Gly Ile Arg Asp Glu Ala Thr Thr Arg Ala Ala Ala
85 90 95

Leu Phe Ile Arg Gly Glu Gln Gln Glu Asp Gly Thr Trp Asn Thr Phe
100 105 110

Tyr Gly Gly Pro Gly Asp Leu Ser Ala Thr Ile Glu Gly Tyr Val Ala
115 120 125

Leu Arg Leu Ala Gly Asp Ser Pro Glu Ala Pro His Met Arg Lys Ala
130 135 140

Ser Ala Phe Val Arg Ala Gln Gly Gly Val Ala Arg Ala Arg Val Phe
145 150 155 160

Thr Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu
165 170 175

Pro Glu Met Pro Pro Glu Leu Met Phe Phe Pro Lys Trp Ala Pro Leu
180 185 190

Asn Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu
195 200 205

Thr Val Val Cys Ala Gln Arg Pro Val Arg Pro Ala Pro Phe Ala Leu
210 215 220

Glu Glu Leu His Thr Asp Pro Ala Asp Pro Asp Pro Ala Gln Pro Ala
225 230 235 240

Pro Pro Val Val Ser Trp Asp Asn Val Phe His Lys Leu Asp Lys Leu
245 250 255

Leu His Gly Tyr Arg Arg Ile Ala Pro Arg Arg Val Arg Glu Ala Ala
260 265 270

Met Arg Ala Ala Ala Thr Trp Ile Val Glu Arg Gln Glu Asn Asp Gly
275 280 285

Cys Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Ile Met Ala Leu
290 295 300

Asn Leu Leu Gly Tyr Asp Leu Asp His Pro Val Leu Arg Ala Gly Leu
305 310 315 320

Ala Ser Leu Asp Arg Phe Ala Val Trp Arg Glu Asp Gly Ala Arg Met
325 330 335

Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Val
340 345 350

Ala Leu Ala Asp Ala Gly Val Pro Ala Asp His Pro Gln Met Ile Lys
355 360 365

Ala Ala Asp Trp Met Leu Ala Glu Gln Ile Val Arg Pro Gly Asp Trp
370 375 380

Val Val Arg Arg Pro Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe
385 390 395 400

His Asn Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu
405 410 415

Ala Leu Arg Arg Val Ala His Pro Asp Ala Thr Arg Val Asp Lys Ala
420 425 430

Val Arg Arg Ala Val Asp Trp Asn Val Gly Met Gln Ser Lys Asn Gly
435 440 445

Ala Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg
450 455 460

Leu Pro Phe Ser Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp
465 470 475 480

Val Thr Ala His Val Val Glu Met Leu Ala Glu Glu Gly Leu Ala His
485 490 495

His Pro Arg Thr Arg Arg Gly Ile Glu Trp Leu Leu Lys Asn Gln Glu
500 505 510

Gly Asn Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly
515 520 525

Thr Gly Ala Val Val Pro Ala Leu Val Ala Ala Gly Leu Pro Ala Ser
530 535 540

His Pro Ala Ile Arg Arg Ser Val Ser Trp Leu Gly Gln Val Gln Asn
545 550 555 560

Glu Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Gln Asp Ser Ala
565 570 575

Trp His Gly Arg Gly His Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu
580 585 590

Leu Ala Leu Leu Ala Ala Gly Glu Arg Glu Thr Glu Gln Val Arg Arg
595 600 605

Gly Ile Ala Tyr Leu Val Glu Thr Gln Thr Glu Asp Gly Thr Trp Asp
610 615 620

Glu Pro Trp Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Thr Ile Asn
625 630 635 640

Tyr His Leu Tyr Arg Gln Val Phe Pro Val Thr Ala Leu Gly Arg Tyr
645 650 655

Leu Asn Gly Thr Gly Pro Gly Glu Asn
660 665


<210> 239
<211> 606
<212> PRT
<213> Streptomyces sp. SPB78

<400> 239
Met Asp Phe Leu Leu Asp Arg Gln Ser Asp Glu Gly Trp Trp Lys Gly
1 5 10 15

Asp Leu Ala Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu Arg
20 25 30

Gln Phe Leu Gly Ile Arg Asp Glu Ala Thr Thr Gln Ala Ala Ala Leu
35 40 45

Phe Ile Arg Gly Glu Gln Gln Glu Asp Gly Thr Trp Asn Thr Phe Tyr
50 55 60

Gly Gly Pro Gly Asp Leu Ser Ala Thr Ile Glu Gly Tyr Val Ala Leu
65 70 75 80

Arg Leu Ala Gly Asp Ser Pro Glu Ala Pro His Met Arg Lys Ala Ser
85 90 95

Ala Phe Val Arg Ala Arg Gly Gly Val Ala Arg Ala Arg Val Phe Thr
100 105 110

Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu Pro
115 120 125

Glu Met Pro Pro Glu Leu Met Phe Phe Pro Lys Trp Ala Pro Leu Asn
130 135 140

Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr
145 150 155 160

Val Val Cys Ala Gln Arg Pro Val Arg Pro Ala Pro Phe Ala Leu Glu
165 170 175

Glu Leu His Thr Asp Pro Ala Asp Pro Asn Pro Ala Gln Pro Ala Pro
180 185 190

Pro Val Ala Ser Trp Asp Asn Val Phe His Lys Leu Asp Lys Met Leu
195 200 205

His Gly Tyr Arg Lys Val Ala Pro Arg Arg Val Arg Glu Ala Ala Met
210 215 220

Arg Ala Ala Ala Thr Trp Ile Val Glu Arg Gln Glu Asn Asp Gly Cys
225 230 235 240

Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Ile Ile Ala Leu His
245 250 255

Leu Leu Gly Tyr Asp Leu Asp His Pro Val Leu Arg Ala Gly Leu Glu
260 265 270

Ser Leu Asp Arg Phe Ala Val Trp Arg Glu Asp Gly Ala Arg Met Ile
275 280 285

Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Val Ala
290 295 300

Leu Ala Asp Ala Gly Val Pro Ala Asp His Pro Gln Met Ile Arg Ala
305 310 315 320

Ala Asp Trp Met Leu Ala Glu Gln Ile Val Arg Pro Gly Asp Trp Val
325 330 335

Val Arg Arg Pro Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His
340 345 350

Asn Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu Ala
355 360 365

Leu Arg Arg Val Ala His Pro Asp Ala Thr Arg Val Asp Lys Ala Val
370 375 380

Arg Arg Ala Val Asp Trp Asn Ala Gly Met Gln Ser Lys Asn Gly Ala
385 390 395 400

Trp Gly Ala Phe Asp Ala Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu
405 410 415

Pro Phe Ser Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val
420 425 430

Thr Ala His Val Val Glu Met Leu Ala Glu Glu Gly Leu Ala His His
435 440 445

Pro Arg Thr Arg Arg Gly Ile Glu Trp Leu Leu Glu Asn Gln Glu Ala
450 455 460

Asn Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr
465 470 475 480

Gly Ala Val Val Pro Ala Leu Val Ala Ala Gly Ile Pro Ala Ala His
485 490 495

Pro Ala Ile Arg Arg Ser Val Ser Trp Leu Gly Gln Val Gln Asn Glu
500 505 510

Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Gln Asp Thr Ala Trp
515 520 525

His Gly Arg Gly His Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu
530 535 540

Ala Leu Leu Ala Ala Gly Glu Arg Asp Ser Glu Gln Val Arg Arg Gly
545 550 555 560

Ile Ala Tyr Leu Val Glu Thr Gln Thr Glu Asp Gly Thr Trp Asp Glu
565 570 575

Pro Trp Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Thr Ile Asn Tyr
580 585 590

His Leu Tyr Arg Gln Val Phe Pro Val Thr Ala Leu Gly Arg
595 600 605


<210> 240
<211> 669
<212> PRT
<213> Streptomyces sviceus

<400> 240
Met His Glu Gly Glu Ala Met Thr Ala Thr Thr Asp Gly Ser Thr Gly
1 5 10 15

Ala Leu Pro Pro Arg Ala Ala Ala Ala Ser Glu Thr His Leu Asp Thr
20 25 30

Pro Val Ala Ala Gly Ile Gln Glu Ala Ala Val Arg Ala Val Gln Arg
35 40 45

Ala Thr Glu His Leu Leu Ala Arg Gln Asp Ala Glu Gly Trp Trp Lys
50 55 60

Gly Asp Leu Glu Thr Asn Val Thr Met Asp Ala Glu Asp Leu Leu Leu
65 70 75 80

Arg Gln Phe Leu Gly Ile Arg Asp Glu Ser Thr Thr Arg Ala Ala Ala
85 90 95

Lys Phe Ile Arg Gly Glu Gln Arg Glu Asp Gly Thr Trp Ala Gly Phe
100 105 110

Tyr Gly Gly Pro Gly Glu Leu Ser Thr Thr Val Glu Ala Tyr Val Ala
115 120 125

Leu Arg Leu Asp Gly Asp Ala Pro Asp Ala Pro His Met Ala Lys Ala
130 135 140

Ser Ala Trp Ile Arg Ala Gln Gly Gly Ile Ala Ala Ala Arg Val Phe
145 150 155 160

Thr Arg Ile Trp Leu Ala Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu
165 170 175

Pro Glu Leu Pro Pro Glu Leu Ile Tyr Phe Pro Lys Trp Ala Pro Leu
180 185 190

Asn Ile Tyr Asp Phe Gly Cys Trp Ala Arg Gln Thr Ile Val Pro Leu
195 200 205

Thr Ile Val Ser Ala Lys Arg Pro Val Arg Pro Ala Pro Phe Pro Leu
210 215 220

Asp Glu Leu His Ala Asp Pro Ala Asp Pro Asn Pro Ala Lys Pro Leu
225 230 235 240

Ala Pro Val Ala Ser Trp Asp Gly Ala Phe Gln Arg Leu Asp Lys Ala
245 250 255

Met His Gln Leu Arg Lys Val Ala Pro Arg Arg Leu Arg Arg Ala Ala
260 265 270

Met Asn Ser Ala Ala Arg Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly
275 280 285

Cys Trp Gly Gly Ile Gln Pro Pro Ala Val Tyr Ser Val Ile Ala Leu
290 295 300

His Leu Leu Gly Tyr Asp Leu Gln His Pro Val Met Arg Ala Gly Leu
305 310 315 320

Glu Ser Leu Asp Arg Phe Ala Ile Trp Arg Glu Asp Gly Ser Arg Met
325 330 335

Ile Glu Ala Cys Gln Ser Pro Val Trp Asp Thr Cys Leu Ala Thr Ile
340 345 350

Ala Leu Val Asp Ala Gly Val Pro Ala Asp His Pro Gln Leu Val Lys
355 360 365

Ala Ala Asp Trp Met Leu Gly Glu Glu Ile Val Arg Pro Gly Asp Trp
370 375 380

Ser Val Lys Arg Pro Gln Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe
385 390 395 400

His Asn Asp Asn Tyr Pro Asp Ile Asp Asp Thr Ala Glu Val Val Leu
405 410 415

Ala Leu Arg Arg Val Arg His His Asp Pro Asp Arg Val Glu Asn Ala
420 425 430

Ile Gly Arg Gly Val Arg Trp Asn Leu Gly Met Gln Ser Lys Asn Gly
435 440 445

Ala Trp Gly Ala Phe Asp Val Asp Asn Thr Ser Pro Phe Pro Asn Arg
450 455 460

Leu Pro Phe Cys Asp Phe Gly Glu Val Ile Asp Pro Pro Ser Ala Asp
465 470 475 480

Val Thr Ala His Val Val Glu Met Leu Ala Val Glu Gly Leu Ser His
485 490 495

Asp Pro Arg Thr Arg Arg Gly Ile Glu Trp Leu Leu Ala Glu Gln Glu
500 505 510

Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
515 520 525

Thr Gly Ser Val Val Pro Ala Leu Thr Ala Ala Gly Leu Pro Ala Ser
530 535 540

His Pro Ala Ile Arg Arg Ala Val Ala Trp Leu Glu Lys Val Gln Asn
545 550 555 560

Asp Asp Gly Gly Trp Gly Glu Asp Leu Arg Ser Tyr Lys Tyr Val Lys
565 570 575

Glu Trp Ser Gly Arg Gly Ala Ser Thr Ala Ser Gln Thr Ala Trp Ala
580 585 590

Leu Met Ala Leu Leu Ala Ala Gly Glu Arg Asp Ser Lys Ala Val Glu
595 600 605

Arg Gly Val Glu Trp Leu Ala Ser Thr Gln Arg Ala Asp Gly Ser Trp
610 615 620

Asp Glu Pro Tyr Phe Thr Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile
625 630 635 640

Asn Tyr His Leu Tyr Arg Gln Val Phe Pro Leu Thr Ala Leu Gly Arg
645 650 655

Tyr Val His Gly Glu Pro Phe Ser Arg Thr Glu Ala Leu
660 665


<210> 241
<211> 664
<212> PRT
<213> Streptomyces viridochromogenes

<400> 241
Met Thr Ala Thr Thr Asp Gly Ser Thr Gly Ala Leu Pro Pro Arg Ala
1 5 10 15

Asp Ala Ala Ser Glu His Asp Ile Glu Thr Pro Glu Ala Ala Gly Val
20 25 30

Arg Glu Ala Ala Val Arg Ala Ala Arg Arg Ala Thr Asp Phe Leu Leu
35 40 45

Ser Arg Gln Asp Ala Gln Gly Trp Trp Lys Gly Asp Leu Glu Thr Asn
50 55 60

Val Thr Met Asp Ala Glu Asp Leu Met Leu Arg Gln Phe Leu Gly Val
65 70 75 80

Leu Asp Glu Lys Thr Ala Gln Ala Ala Ala Leu Phe Ile Arg Gly Glu
85 90 95

Gln Arg Glu Asp Gly Thr Trp Ala Ser Phe Tyr Gly Gly Pro Gly Glu
100 105 110

Leu Ser Thr Thr Ile Glu Ala Tyr Val Ala Leu Arg Leu Ala Gly Asp
115 120 125

Ala Pro Asp Ser Pro His Leu Ala Lys Ala Ser Ala Trp Ile Arg Glu
130 135 140

Gln Gly Gly Ile Ala Ala Ala Arg Val Phe Thr Arg Ile Trp Leu Ala
145 150 155 160

Leu Phe Gly Trp Trp Lys Trp Glu Asp Leu Pro Glu Leu Pro Pro Glu
165 170 175

Leu Ile Trp Phe Pro Lys Trp Val Pro Leu Asn Ile Tyr Asp Phe Gly
180 185 190

Cys Trp Ala Arg Gln Thr Ile Val Pro Leu Thr Ile Val Ser Ala Lys
195 200 205

Arg Pro Val Arg Pro Ala Pro Phe Pro Leu Asp Glu Leu His Thr Asp
210 215 220

Pro Ala Arg Pro Asn Pro Pro Arg Pro Leu Ala Pro Ala Phe Ser Trp
225 230 235 240

Asp Gly Ala Phe Gln Arg Met Asp Lys Gly Leu His Ala Leu Arg Lys
245 250 255

Val Ala Pro Arg Gly Leu Arg Arg Ala Ala Met Asn Ala Ala Ala Arg
260 265 270

Trp Ile Ile Glu Arg Gln Glu Asn Asp Gly Cys Trp Gly Gly Ile Gln
275 280 285

Pro Pro Ala Val Tyr Ser Ile Ile Ala Leu His Leu Leu Gly Tyr Asp
290 295 300

Leu Gln His Pro Val Met Arg Glu Gly Leu Ala Ser Leu Asp Arg Phe
305 310 315 320

Ala Val Trp Arg Glu Asp Gly Ala Arg Met Val Glu Ala Cys Gln Ser
325 330 335

Pro Val Trp Asp Thr Cys Leu Ala Ala Ile Ala Leu Val Asp Ala Gly
340 345 350

Leu Pro Ala Asp His Pro Gln Leu Val Lys Ala Ala Asp Trp Met Leu
355 360 365

Gly Glu Glu Ile Val Arg Pro Gly Asp Trp Ser Val Arg Arg Pro Gly
370 375 380

Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Asn Tyr Pro
385 390 395 400

Asp Ile Asp Asp Thr Ala Glu Val Ile Leu Ala Leu Arg Arg Ile Thr
405 410 415

His His Asp Pro Val Arg Val Asp Lys Ala Val Gly Arg Gly Val Arg
420 425 430

Trp Thr Leu Gly Met Gln Ser Lys Asn Gly Ala Trp Ala Ala Phe Asp
435 440 445

Val Asp Asn Thr Ser Pro Phe Pro Asn Arg Leu Pro Phe Cys Asp Phe
450 455 460

Gly Glu Val Ile Asp Pro Pro Ser Ala Asp Val Thr Ala His Val Ile
465 470 475 480

Glu Met Leu Ala Val Glu Gly Leu Ala His Asp Pro Arg Thr Arg Arg
485 490 495

Gly Ile Glu Trp Leu Leu Ala Glu Gln Glu Pro Asp Gly Ser Trp Phe
500 505 510

Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Gly Ser Val Val Pro
515 520 525

Ala Leu Val Ala Ala Gly Leu Pro Gly Ala His Pro Ala Ile Arg Arg
530 535 540

Ala Val Ser Trp Leu Glu Ser Val Gln Asn Asp Asp Gly Gly Trp Gly
545 550 555 560

Glu Asp Leu Arg Ser Tyr Lys Tyr Val Lys Glu Trp Ser Gly Arg Gly
565 570 575

Ala Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Met Ala Leu Leu Ala
580 585 590

Ala Gly Glu Arg Asp Ser Lys Ala Val Glu Arg Gly Val Glu Trp Leu
595 600 605

Ala Ala Thr Gln Arg Glu Asp Gly Ser Trp Asp Glu Pro Tyr Phe Thr
610 615 620

Gly Thr Gly Phe Pro Trp Asp Phe Ser Ile Asn Tyr His Leu Tyr Arg
625 630 635 640

Gln Val Phe Pro Leu Thr Ala Leu Gly Arg Tyr Val His Gly Glu Pro
645 650 655

Phe Ala Asp Arg Leu Lys Gly Ser
660


<210> 242
<211> 653
<212> PRT
<213> Synechococcus sp.

<400> 242
Met Ser Ile Ser Ala Leu Gln Thr Asp Arg Leu Ser Gln Thr Leu Thr
1 5 10 15

Gln Ser Val Val Ala Ala Gln Gln His Leu Leu Ser Ile Gln Asn Pro
20 25 30

Glu Gly Tyr Trp Trp Ala Asn Leu Glu Ser Asn Ala Ser Ile Thr Ala
35 40 45

Glu Val Val Leu Leu His Lys Ile Trp Gly Thr Leu Asp Ser Gln Pro
50 55 60

Leu Ala Lys Leu Glu Asn Tyr Leu Arg Ala Gln Gln Lys Thr His Gly
65 70 75 80

Gly Trp Glu Leu Tyr Trp Asn Asp Gly Gly Glu Leu Ser Thr Ser Val
85 90 95

Glu Ala Tyr Met Gly Leu Arg Leu Leu Gly Val Pro Ala Ser Asp Pro
100 105 110

Ala Leu Val Lys Ala Lys Gln Phe Ile Leu His Arg Gly Gly Val Ser
115 120 125

Lys Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile Gly Cys Tyr
130 135 140

Arg Trp Gln Gly Leu Pro Ser Leu Pro Ala Trp Val Met Gln Leu Glu
145 150 155 160

Ser Pro Phe Pro Phe Ser Ile Tyr Glu Leu Ser Ser Trp Ala Arg Gly
165 170 175

Ser Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys Pro Val Tyr Pro
180 185 190

Leu Gln Pro Ser Pro Thr Leu Asp Glu Leu Phe Thr Glu Ser Ala Glu
195 200 205

Asn Val Arg Trp Glu Leu Glu Glu Lys Gly Asp Trp Ser Asp Ala Phe
210 215 220

Leu Trp Leu Asp Lys Ala Phe Lys Leu Ala Glu Ser Val Asp Leu Val
225 230 235 240

Pro Phe Arg Glu Glu Ser Ile Arg Lys Ala Glu Lys Trp Val Leu Glu
245 250 255

Arg Gln Glu Pro Ser Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu
260 265 270

Asn Ser Met Leu Ala Leu Arg Ala Leu Gly Tyr Ser Val Ser Asp Pro
275 280 285

Val Val Arg Arg Gly Phe Gln Ala Ile Asp Asn Phe Met Val Glu Ser
290 295 300

Glu Thr Glu Cys Trp Ala Gln Pro Cys Ile Ser Pro Val Trp Asp Thr
305 310 315 320

Gly Leu Ala Val Arg Ser Leu Thr Asp Ser Gly Leu Ser Pro Asn His
325 330 335

Pro Ala Leu Val Lys Ala Gly Glu Trp Leu Leu Asp Lys Gln Ile Leu
340 345 350

Ser Tyr Gly Asp Trp Ser Val Lys Asn Pro Gln Gly Gln Pro Gly Gly
355 360 365

Trp Ala Phe Glu Phe Glu Asn Ser Phe Tyr Pro Asp Val Asp Asp Thr
370 375 380

Ala Val Val Ala Met Ala Leu Gln Asp Ile Thr Leu Pro Asn Glu Pro
385 390 395 400

Leu Lys Arg Arg Ala Ile Ala Arg Ala Val Arg Trp Ile Ala Thr Met
405 410 415

Gln Cys Lys Thr Gly Gly Trp Ala Ala Phe Asp Ile Asn Asn Asp Gln
420 425 430

Asp Trp Leu Asn Asp Ile Pro Tyr Gly Asp Leu Arg Ala Met Ile Asp
435 440 445

Pro Ser Thr Ala Asp Ile Thr Gly Arg Val Leu Glu Met His Gly Arg
450 455 460

Phe Ala Ala Asp Leu Asp Leu Ala Asn Ser Tyr Ala Ala Asp Leu Ser
465 470 475 480

Pro Tyr Arg Leu Ser Arg Gly Leu Asn Tyr Leu Ile Lys Glu Gln Glu
485 490 495

Leu Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
500 505 510

Thr Gly Gln Ala Leu Ser Ala Leu Ala Leu Ile Ala Pro Glu Arg Cys
515 520 525

Arg Ile Gln Ile Glu Arg Gly Ile Ala Trp Phe Val Ser Val Gln Asn
530 535 540

Ala Asp Gly Gly Trp Gly Glu Thr Cys Glu Ser Tyr Lys Asp Lys Ser
545 550 555 560

Leu Lys Gly Lys Gly Ile Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu
565 570 575

Leu Gly Leu Leu Asp Val Ser Phe Cys Leu Asp Pro Ala Ala Lys Ile
580 585 590

Ala Val Asp Arg Gly Ile Gln Tyr Leu Val Ser Thr Gln Ser Glu Gly
595 600 605

Thr Trp Gln Glu Glu Ser Phe Thr Gly Thr Gly Phe Pro Gln His Phe
610 615 620

Tyr Leu Arg Tyr Arg Leu Tyr Cys His Tyr Phe Pro Leu Met Ala Leu
625 630 635 640

Gly Arg Tyr Gln Arg Val Ile Asn Ser Ser Ala Gly Ile
645 650


<210> 243
<211> 653
<212> PRT
<213> Synechococcus sp. PCC 7335

<400> 243
Met Ser Ile Ser Ala Leu Gln Thr Asp Arg Leu Ser Gln Thr Leu Thr
1 5 10 15

Gln Ser Val Val Ala Ala Gln Gln His Leu Leu Ser Ile Gln Asn Pro
20 25 30

Glu Gly Tyr Trp Trp Ala Asn Leu Glu Ser Asn Ala Ser Ile Thr Ala
35 40 45

Glu Val Val Leu Leu His Lys Ile Trp Gly Thr Leu Asp Ser Gln Pro
50 55 60

Leu Ala Lys Leu Glu Asn Tyr Leu Arg Ala Gln Gln Lys Thr His Gly
65 70 75 80

Gly Trp Glu Leu Tyr Trp Asn Asp Gly Gly Glu Leu Ser Thr Ser Val
85 90 95

Glu Ala Tyr Met Gly Leu Arg Leu Leu Gly Val Pro Ala Ser Asp Pro
100 105 110

Ala Leu Val Lys Ala Lys Gln Phe Ile Leu His Arg Gly Gly Val Ser
115 120 125

Lys Thr Arg Ile Phe Thr Lys Phe His Leu Ala Leu Ile Gly Cys Tyr
130 135 140

Arg Trp Gln Gly Leu Pro Ser Leu Pro Ala Trp Val Met Gln Leu Glu
145 150 155 160

Ser Pro Phe Pro Phe Ser Ile Tyr Glu Leu Ser Ser Trp Ala Arg Gly
165 170 175

Ser Thr Val Pro Leu Leu Ile Val Phe Asp Lys Lys Pro Val Tyr Pro
180 185 190

Leu Gln Pro Ser Pro Thr Leu Asp Glu Leu Phe Thr Glu Ser Ala Glu
195 200 205

Asn Val Arg Trp Glu Leu Glu Glu Lys Gly Asp Trp Ser Asp Ala Phe
210 215 220

Leu Trp Leu Asp Lys Ala Phe Lys Leu Ala Glu Ser Val Asp Leu Val
225 230 235 240

Pro Phe Arg Glu Glu Ser Ile Arg Lys Ala Glu Lys Trp Val Leu Glu
245 250 255

Arg Gln Glu Pro Ser Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu
260 265 270

Asn Ser Met Leu Ala Leu Arg Ala Leu Gly Tyr Ser Val Ser Asp Pro
275 280 285

Val Val Arg Arg Gly Phe Gln Ala Ile Asp Asn Phe Met Val Glu Ser
290 295 300

Glu Thr Glu Cys Trp Ala Gln Pro Cys Ile Ser Pro Val Trp Asp Thr
305 310 315 320

Gly Leu Ala Val Arg Ser Leu Thr Asp Ser Gly Leu Ser Pro Asn His
325 330 335

Pro Ala Leu Val Lys Ala Gly Glu Trp Leu Leu Asp Lys Gln Ile Leu
340 345 350

Ser Tyr Gly Asp Trp Ser Val Lys Asn Pro Gln Gly Gln Pro Gly Gly
355 360 365

Trp Ala Phe Glu Phe Glu Asn Ser Phe Tyr Pro Asp Val Asp Asp Thr
370 375 380

Ala Val Val Ala Met Ala Leu Gln Asp Ile Thr Leu Pro Asn Glu Pro
385 390 395 400

Leu Lys Arg Arg Ala Ile Ala Arg Ala Val Arg Trp Ile Ala Thr Met
405 410 415

Gln Cys Lys Thr Gly Gly Trp Ala Ala Phe Asp Ile Asn Asn Asp Gln
420 425 430

Asp Trp Leu Asn Asp Ile Pro Tyr Gly Asp Leu Arg Ala Met Ile Asp
435 440 445

Pro Ser Thr Ala Asp Ile Thr Gly Arg Val Leu Glu Met His Gly Arg
450 455 460

Phe Ala Ala Asp Leu Asp Leu Ala Asn Ser Tyr Ala Ala Asp Leu Ser
465 470 475 480

Pro Tyr Arg Leu Ser Arg Gly Leu Asn Tyr Leu Ile Lys Glu Gln Glu
485 490 495

Leu Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
500 505 510

Thr Gly Gln Ala Leu Ser Ala Leu Ala Leu Ile Ala Pro Glu Arg Cys
515 520 525

Arg Ile Gln Ile Glu Arg Gly Ile Ala Trp Phe Val Ser Val Gln Asn
530 535 540

Ala Asp Gly Gly Trp Gly Glu Thr Cys Glu Ser Tyr Lys Asp Lys Ser
545 550 555 560

Leu Lys Gly Lys Gly Ile Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu
565 570 575

Leu Gly Leu Leu Asp Val Ser Phe Cys Leu Asp Pro Ala Ala Lys Ile
580 585 590

Ala Val Asp Arg Gly Ile Gln Tyr Leu Val Ser Thr Gln Ser Glu Gly
595 600 605

Thr Trp Gln Glu Glu Ser Phe Thr Gly Thr Gly Phe Pro Gln His Phe
610 615 620

Tyr Leu Arg Tyr Arg Leu Tyr Cys His Tyr Phe Pro Leu Met Ala Leu
625 630 635 640

Gly Arg Tyr Gln Arg Val Ile Asn Ser Ser Ala Gly Ile
645 650


<210> 244
<211> 647
<212> PRT
<213> Synechocystis sp.

<400> 244
Met Val Ile Ala Ala Ser Pro Ser Val Pro Cys Pro Ser Thr Glu Gln
1 5 10 15

Val Arg Gln Ala Ile Ala Ala Ser Arg Asp Phe Leu Leu Ser Glu Gln
20 25 30

Tyr Ala Asp Gly Tyr Trp Trp Ser Glu Leu Glu Ser Asn Val Thr Ile
35 40 45

Thr Ala Glu Val Val Ile Leu His Lys Ile Trp Gly Thr Ala Ala Gln
50 55 60

Arg Pro Leu Glu Lys Ala Lys Asn Tyr Leu Leu Gln Gln Gln Arg Asp
65 70 75 80

His Gly Gly Trp Glu Leu Tyr Tyr Gly Asp Gly Gly Glu Leu Ser Thr
85 90 95

Ser Val Glu Ala Tyr Thr Ala Leu Arg Ile Leu Gly Val Pro Ala Thr
100 105 110

Asp Pro Ala Leu Val Lys Ala Lys Asn Phe Ile Val Gly Arg Gly Gly
115 120 125

Ile Ser Lys Ser Arg Ile Phe Thr Lys Met His Leu Ala Leu Ile Gly
130 135 140

Cys Tyr Asp Trp Arg Gly Thr Pro Ser Ile Pro Pro Trp Val Met Leu
145 150 155 160

Leu Pro Asn Asn Phe Phe Phe Asn Ile Tyr Glu Met Ser Ser Trp Ala
165 170 175

Arg Ser Ser Thr Val Pro Leu Met Ile Val Cys Asp Gln Lys Pro Val
180 185 190

Tyr Asp Ile Ala Gln Gly Leu Arg Val Asp Glu Leu Tyr Ala Glu Gly
195 200 205

Met Glu Asn Val Gln Tyr Lys Leu Pro Glu Ser Gly Thr Ile Trp Asp
210 215 220

Ile Phe Ile Gly Leu Asp Ser Leu Phe Lys Leu Gln Glu Gln Ala Lys
225 230 235 240

Val Val Pro Phe Arg Glu Gln Gly Leu Ala Leu Ala Glu Lys Trp Ile
245 250 255

Leu Glu Arg Gln Glu Val Ser Gly Asp Trp Gly Gly Ile Ile Pro Ala
260 265 270

Met Leu Asn Ser Leu Leu Ala Leu Lys Val Leu Gly Tyr Asp Val Asn
275 280 285

Asp Leu Tyr Val Gln Arg Gly Leu Ala Ala Ile Asp Asn Phe Ala Val
290 295 300

Glu Thr Glu Asp Ser Tyr Ala Ile Gln Ala Cys Val Ser Pro Val Trp
305 310 315 320

Asp Thr Ala Trp Val Val Arg Ala Leu Ala Glu Ala Asp Leu Gly Lys
325 330 335

Asp His Pro Ala Leu Val Lys Ala Gly Gln Trp Leu Leu Asp Lys Gln
340 345 350

Ile Leu Thr Tyr Gly Asp Trp Gln Ile Lys Asn Pro His Gly Glu Pro
355 360 365

Gly Ala Trp Ala Phe Glu Phe Asp Asn Asn Phe Tyr Pro Asp Ile Asp
370 375 380

Asp Thr Cys Val Val Met Met Ala Leu Gln Gly Ile Thr Leu Pro Asp
385 390 395 400

Glu Glu Arg Lys Gln Gly Ala Ile Asn Lys Ala Leu Gln Trp Ile Ala
405 410 415

Thr Met Gln Cys Lys Thr Gly Gly Trp Ala Ala Phe Asp Ile Asp Asn
420 425 430

Asp Gln Asp Trp Leu Asn Gln Leu Pro Tyr Gly Asp Leu Lys Ala Met
435 440 445

Ile Asp Pro Ser Thr Ala Asp Ile Thr Ala Arg Val Val Glu Met Leu
450 455 460

Gly Ala Cys Gly Leu Thr Met Asp Ser Pro Arg Val Glu Arg Gly Leu
465 470 475 480

Thr Tyr Leu Leu Gln Glu Gln Glu Gln Asp Gly Ser Trp Phe Gly Arg
485 490 495

Trp Gly Val Asn Tyr Leu Tyr Gly Thr Ser Gly Ala Leu Ser Ala Leu
500 505 510

Ala Ile Tyr Asp Ala Gln Arg Phe Ala Pro Gln Ile Lys Thr Ala Ile
515 520 525

Ala Trp Leu Leu Ser Cys Gln Asn Ala Asp Gly Gly Trp Gly Glu Thr
530 535 540

Cys Glu Ser Tyr Lys Asn Lys Gln Leu Lys Gly Gln Gly Asn Ser Thr
545 550 555 560

Ala Ser Gln Thr Ala Trp Ala Leu Ile Gly Leu Leu Asp Ala Leu Lys
565 570 575

Tyr Leu Pro Ser Leu Gly Gln Asp Ala Lys Leu Thr Thr Ala Ile Glu
580 585 590

Gly Gly Val Ala Phe Leu Val Gln Gly Gln Thr Pro Lys Gly Thr Trp
595 600 605

Glu Glu Ala Glu Tyr Thr Gly Thr Gly Phe Pro Cys His Phe Tyr Ile
610 615 620

Arg Tyr His Tyr Tyr Arg Gln Tyr Phe Pro Leu Ile Ala Leu Ala Arg
625 630 635 640

Tyr Ser His Leu Gln Ala Ser
645


<210> 245
<211> 688
<212> PRT
<213> Syntrophobacter fumaroxidans

<400> 245
Met Asn Pro Ile Arg Gly Lys Arg Gly Ser Ala Ala Asp Phe Leu Glu
1 5 10 15

Glu Glu Tyr Gln Trp Glu Asn Leu Ala Asp His Gly Glu Ser Gly Arg
20 25 30

Thr Pro Gly Gly Gly His Pro Ala Ala Leu Lys Glu Tyr Glu Ala Gly
35 40 45

Ser Ala Thr Glu His Thr Gly His His Cys Val His His Leu Gly Val
50 55 60

Arg Asn Ser Trp Leu Arg Lys Ile Glu Lys Ala Ile Asp Asn Ala Cys
65 70 75 80

Gly Gln Leu Phe Lys Thr Gln Tyr Glu Asp Gly Tyr Trp Trp Ser Glu
85 90 95

Leu Glu Ser Asn Val Thr Ile Thr Ser Glu Tyr Ile Met Leu Leu Tyr
100 105 110

Leu Leu Glu Val Ser Arg Pro Glu Gln Gln Lys Ser Met Val Lys Tyr
115 120 125

Leu Leu Asn Gln Gln Arg Pro Asp Gly Ser Trp Gly Leu Tyr Tyr Gly
130 135 140

Asp Gly Gly Asn Leu Ser Thr Thr Ile Glu Ala Tyr Phe Ala Leu Lys
145 150 155 160

Leu Ala Gly Glu His Cys Glu Ser Glu Pro Met Arg Arg Ala Arg Glu
165 170 175

Phe Ile Leu Ser Lys Gly Gly Ile Glu Ser Ala Arg Val Phe Thr Lys
180 185 190

Ile Trp Leu Ala Leu Phe Ser Gln Tyr Asp Trp Asp Lys Val Pro Ser
195 200 205

Met Pro Val Glu Leu Val Leu Leu Pro Ser Ser Leu Tyr Phe Asn Ile
210 215 220

Tyr Glu Phe Ser Ser Trp Ala Arg Gly Thr Val Val Pro Leu Ser Ile
225 230 235 240

Val Met Ser Ile Arg Pro Arg Cys Pro Leu Pro Ala Lys Cys Ser Ile
245 250 255

Lys Glu Leu Tyr Val Pro Gly Ser Lys His Lys Asn Phe Ala Ser Cys
260 265 270

Thr His Lys Leu Phe Phe Leu Phe Asp Arg Ile Ala Lys Ala Phe Glu
275 280 285

Arg Arg Pro Val Pro Ser Leu Arg Asn Lys Ala Val Gln Ala Ala Glu
290 295 300

Thr Trp Val Leu Asp His Gln Glu Asp Ser Gly Asp Trp Gly Gly Ile
305 310 315 320

Gln Pro Pro Met Val Tyr Ser Val Leu Ala Leu Tyr Tyr Leu Gly Tyr
325 330 335

Pro Leu Asp His Glu Val Ile Val Lys Gly Ile Lys Ala Leu Asp Ala
340 345 350

Phe Cys Met Glu Asp Glu Glu Gly Thr Arg Met Gln Ser Cys Val Ser
355 360 365

Pro Val Trp Asp Thr Ala Leu Thr Val Leu Ser Met Leu Asp Ala Gly
370 375 380

Val Ala Ala Glu His Pro Gly Leu Glu Lys Ala Gly Arg Trp Leu Leu
385 390 395 400

Glu Asn Gln Val Leu Thr Gly Gly Asp Trp Gln Ile Lys Asn Asp Ser
405 410 415

Leu Pro Gly Gly Trp Ala Phe Glu Phe Tyr Asn Thr Arg Tyr Pro Asp
420 425 430

Val Asp Asp Ser Ala Val Val Leu Ser Thr Leu Asn Arg Phe Asn Ala
435 440 445

Glu Arg Val Glu Gly Leu Glu Phe Ala Lys Cys Arg Gly Met Glu Trp
450 455 460

Cys Leu Ser Met Gln Ser Ser Asn Gly Gly Trp Ala Ala Phe Asp Lys
465 470 475 480

Asp Asn Thr Leu Glu Ile Leu Asn Arg Ile Pro Phe Ala Asp Gln Glu
485 490 495

Ala Met Val Asp Tyr Pro Thr Ala Asp Val Thr Gly Arg Val Leu Glu
500 505 510

Ala Met Gly Tyr Leu Gly Tyr Asp Gly Ser His Pro Arg Ala Arg Lys
515 520 525

Ala Ile Gln Phe Leu Lys Lys Arg Gln Glu Arg Asp Gly Cys Trp Trp
530 535 540

Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Lys
545 550 555 560

Gly Leu Ile Ser Ile Gly Glu Asp Pro Arg Ala Ala Tyr Ile Arg Ala
565 570 575

Ala Val Arg Trp Val Lys Asp His Gln Asn Ser Asp Gly Gly Trp Gly
580 585 590

Glu Thr Cys Glu Ser Tyr Glu Asn Pro Glu Leu Arg Gly Gln Gly Pro
595 600 605

Ser Thr Pro Ser Gln Thr Ala Trp Ala Leu Met Ser Leu Ile Ala Cys
610 615 620

Gly Glu Met Lys Ser Gln Glu Ala Ser Arg Gly Ile Gln Tyr Leu Leu
625 630 635 640

Arg Thr Gln Lys Arg Asp Gly Thr Trp Glu Glu Leu His Phe Thr Gly
645 650 655

Thr Gly Phe Pro Lys His Phe Tyr Ile Arg Tyr His Asn Tyr Arg Asn
660 665 670

Cys Phe Pro Leu Met Ala Leu Gly Gln Tyr Leu Arg Ala Leu Glu Arg
675 680 685




<210> 246
<211> 710
<212> PRT
<213> Syntrophobacter fumaroxidans

<400> 246
Met Arg Arg Leu Asp Thr Phe Pro Pro Glu Ile Pro Thr Gly Ser Arg
1 5 10 15

Asp Lys Pro Pro Ser Gly Glu Glu His Ser Cys Ser Thr Pro Ala Glu
20 25 30

Pro Leu Arg Ser Arg Leu Asp Glu Gly Ile Leu Arg Ala Val Asp Trp
35 40 45

Leu Val Cys Asp Gln His Pro Asp Gly Phe Trp Ala Gly Met Leu Gln
50 55 60

Ser Asn Ser Cys Met Glu Ala Glu Trp Val Leu Ala Met His Phe Leu
65 70 75 80

Gly Ile Asp Asp Asp Pro Lys Tyr Asp Gly Val Ile Arg Ala Ile Leu
85 90 95

Gly Glu Gln Arg Ala Asp Gly Ser Trp Gly Val Phe His Lys Ala Pro
100 105 110

Asn Gly Asp Ile Asn Thr Thr Val Glu Cys Tyr Ala Ala Leu Arg Ala
115 120 125

Ser Gly Leu Ala Pro Glu Ser Ala Pro Leu Ser Ser Ala Arg Glu Trp
130 135 140

Ile Leu Ala Gly Gly Gly Leu Ala Asn Ile Arg Asn Phe Thr Lys Tyr
145 150 155 160

Trp Leu Ala Leu Ile Gly Glu Trp Pro Trp Glu Gly Thr Pro Thr Ile
165 170 175

Pro Pro Glu Leu Ile Phe Phe Pro Pro Arg Met Pro Leu Asn Ile Tyr
180 185 190

His Phe Ala Ser Trp Ala Arg Ser Thr Ile Val Pro Leu Ser Ile Leu
195 200 205

Ser Ala Arg Arg Pro Val Arg Pro Leu Pro Glu Asp Arg Arg Leu Asp
210 215 220

Glu Leu Phe Pro Gln Gly Arg Ser Ala Phe Asp Phe Arg Leu Pro Arg
225 230 235 240

Lys Asp Gly Trp Leu Ser Trp Glu Gly Phe Phe His Val Cys Asp Arg
245 250 255

Ile Leu Arg Leu Tyr Ala Arg Thr Arg Arg Ala Pro Phe Arg Glu Thr
260 265 270

Ala Ile Arg Val Cys Leu Glu Trp Ile Ile Arg Arg Gln Glu Thr Asp
275 280 285

Gly Ala Trp Ser Gly Ile Gln Pro Pro Trp Ile Tyr Ala Leu Leu Ala
290 295 300

Leu His Ala Glu Gly Tyr Gly Leu Asp His Pro Ile Leu Arg Ala Gly
305 310 315 320

Leu Arg Ala Phe Asp Ser His Trp Ser Tyr Glu Arg Asp Gly Gly Ile
325 330 335

Tyr Leu Gln Ala Ser Glu Ser Pro Val Trp Asp Thr Val Leu Ser Leu
340 345 350

Arg Ala Leu Ala Asp Cys Gly Glu Glu Arg Lys Ala Ser Val Ser Ile
355 360 365

Ala Ser Ala Leu Glu Trp Leu Leu Asn Arg Gln Ile Ser Val Pro Gly
370 375 380

Asp Trp Ala Val Arg Val Pro Ser Val Pro Cys Gly Gly Trp Ala Phe
385 390 395 400

Gln Arg Ala Asn Ser Phe Tyr Pro Asp Val Asp Asp Thr Ala Val Ala
405 410 415

Ile Glu Val Leu Ala Arg Leu Arg Pro Phe Thr Ala Asn Gln Ser Ala
420 425 430

Val Asp Arg Ala Ile Arg Ser Ala Arg Asp Trp Val Leu Ala Met Gln
435 440 445

Cys Ser Asn Gly Gly Trp Ala Ala Phe Asp Arg Asp Asn Asp Phe Lys
450 455 460

Leu Val Thr Lys Ile Pro Phe Cys Asp Phe Gly Glu Leu Leu Asp Pro
465 470 475 480

Pro Ser Val Asp Val Thr Ala His Val Ile Glu Ala Leu Ala Ala Leu
485 490 495

Gly Trp Asp Met Thr Ser Arg Glu Ile Glu Ala Ala Val Ser Phe Ile
500 505 510

Arg Arg Glu Gln Glu Ala Glu Gly Ser Trp Phe Gly Arg Trp Gly Val
515 520 525

Asn His Ile Tyr Gly Thr Ala Thr Val Leu Pro Ala Leu Arg Ala Ile
530 535 540

Gly Glu Asp Met Ser Ser Ala Tyr Val Leu Arg Ala Ala Asp Trp Leu
545 550 555 560

Ala Ser Arg Gln Asn Ala Asp Gly Gly Trp Gly Glu Thr Pro Ala Ser
565 570 575

Tyr Met Asp Asp Ser Leu Arg Gly Val Gly Glu Ser Thr Ala Ser Gln
580 585 590

Thr Ala Trp Ala Ile Met Gly Leu Val Ala Val Gly Ser Gly Ala His
595 600 605

Asp Asp Thr Val Arg Arg Gly Ile Asp Phe Leu Leu Phe Ala Gln His
610 615 620

Gly Gly Thr Trp Glu Glu Pro Gln Tyr Thr Gly Thr Gly Phe Pro Gly
625 630 635 640

Tyr Ser Val Gly Glu Arg Ile Arg Leu Arg Asp Met Gly Ala Ser Leu
645 650 655

Lys Gln Gly Thr Glu Leu Gln Arg Ala Phe Met Ile Asn Tyr Asn Leu
660 665 670

Tyr Arg His Tyr Phe Pro Leu Met Ala Leu Gly Arg Ala Arg Tyr His
675 680 685

Leu Gln Leu Arg Arg Ser Ala Arg Glu Gly Gly Asn Gly Glu Thr Thr
690 695 700

Pro Asn Gly Ser Ala Leu
705 710


<210> 247
<211> 671
<212> PRT
<213> Teredinibacter turnerae

<400> 247
Met Glu Ile Gln Asp Glu Val Asp Leu Leu Glu Pro Gln Glu Ser Leu
1 5 10 15

Thr Ala Ser Ala Asp Ser Ala Val Asp Arg Ala Leu Phe Trp Leu Leu
20 25 30

Asp Ala Gln Tyr Glu Asp Gly Tyr Trp Ala Gly Ile Leu Glu Ser Asn
35 40 45

Ala Cys Met Glu Ala Glu Trp Leu Leu Cys Phe His Val Leu Gly Ile
50 55 60

Ala Asn His Pro Met Ser Arg Gly Leu Val Gln Gly Leu Leu Gln Arg
65 70 75 80

Gln Arg Ala Asp Gly Ser Trp Asp Val Tyr Tyr Gly Ala Arg Ala Gly
85 90 95

Asp Ile Asn Thr Thr Val Glu Val Tyr Ala Ala Leu Arg Cys Gln Gly
100 105 110

Tyr Ala Ala Asp His Pro Asp Ile Lys Arg Ala Arg Asp Trp Ile Gln
115 120 125

Leu Gln Gly Gly Val Lys Gln Val Arg Val Phe Thr Arg Phe Trp Leu
130 135 140

Ala Leu Ile Gly Glu Trp Pro Trp Glu Glu Thr Pro Asn Leu Pro Pro
145 150 155 160

Glu Ile Leu Phe Phe Pro Arg Trp Phe Pro Phe Asn Ile Tyr His Phe
165 170 175

Ala Ala Trp Ala Arg Ala Thr Leu Val Pro Leu Cys Ile Leu Ser Ala
180 185 190

Arg Arg Met Val Val Pro Leu Asn Lys Lys Ser Cys Leu Gln Glu Leu
195 200 205

Phe Pro Glu Asp Arg Ser Ala Val Val Ala Leu Gly Lys Lys Ala Gly
210 215 220

Ala Trp Ser Thr Phe Phe Tyr His Ala Asp Arg Ala Leu Lys Lys Tyr
225 230 235 240

Gln Arg Thr Phe Lys Arg Pro Pro Gly Arg Gln Gln Ala Ile Lys Met
245 250 255

Cys Leu Glu Trp Ile Leu Arg Arg Gln Asp Ala Asp Gly Ala Trp Gly
260 265 270

Gly Ile Gln Pro Pro Trp Ile Tyr Ser Leu Met Ala Leu Lys Ala Glu
275 280 285

Gly Tyr Pro Val Thr His Pro Val Met Ala Lys Gly Leu Ala Ala Leu
290 295 300

Asp Ala His Trp Ser Tyr Glu Arg Pro Gly Gly Ala Arg Phe Val Gln
305 310 315 320

Ala Cys Glu Ser Pro Val Trp Asp Thr Leu Leu Ser Ser Phe Ala Leu
325 330 335

Leu Asp Cys Gly Phe Ser Cys Thr Ser Ser Ser Glu Leu Arg Lys Ala
340 345 350

Val Asp Trp Ile Leu Asp Gln Gln Val Leu Leu Pro Gly Asp Trp Gln
355 360 365

Gln Lys Leu Pro Thr Val Ser Pro Gly Gly Trp Ala Phe Glu Arg Ala
370 375 380

Asn Val His Tyr Pro Asp Val Asp Asp Thr Ala Val Ala Leu Ile Val
385 390 395 400

Leu Ala Lys Val Arg Pro Asp Tyr Pro Asp Thr Ala Arg Val Asn Leu
405 410 415

Ala Ile Glu Arg Gly Leu Asn Trp Leu Phe Ala Met Gln Cys Arg Asn
420 425 430

Gly Gly Trp Gly Ala Phe Asp Lys Asp Asn Asp Lys Asp Leu Leu Thr
435 440 445

Lys Ile Pro Phe Ser Asp Phe Gly Glu Thr Ile Asp Pro Ala Ser Val
450 455 460

Asp Val Thr Ala His Val Leu Glu Ala Leu Gly Leu Leu Gly Tyr Arg
465 470 475 480

Thr Thr His Pro Ala Val Ala Lys Ala Leu Glu Phe Ile Arg Ser Glu
485 490 495

Gln Glu Asn Asp Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile
500 505 510

Tyr Gly Thr Ala Ala Val Leu Pro Ala Leu Ala Ser Leu Asn Met Asn
515 520 525

Met Asn Gln Glu Phe Ile Arg Arg Ala Ala Asn Trp Ile Leu Gly Lys
530 535 540

Gln Asn Asn Asp Gly Gly Trp Gly Glu Ser Cys Ala Ser Tyr Met Asp
545 550 555 560

Asp Thr Gln Arg Gly Arg Gly Pro Ser Thr Ala Ser Gln Thr Ala Trp
565 570 575

Ala Met Met Ser Leu Leu Ala Val Asp Gly Gly Thr Tyr Ala Glu Ser
580 585 590

Leu Leu Arg Ala Glu Ala Tyr Leu Lys Thr Thr Gln Thr Pro Glu Gly
595 600 605

Thr Trp Asp Glu Pro Tyr Tyr Thr Gly Thr Gly Phe Pro Gly Tyr Gly
610 615 620

Ile Gly Arg Arg Glu Ile Lys Arg Gln Arg Ser Leu Gln Gln His Ala
625 630 635 640

Glu Leu Ser Arg Gly Phe Met Ile Asn Tyr Asn Leu Tyr Arg His Tyr
645 650 655

Phe Pro Leu Met Ala Leu Gly Arg Leu Ala Ala Leu Arg Gly Ala
660 665 670


<210> 248
<211> 642
<212> PRT
<213> Thermosynechococcus elongatus

<400> 248
Met Pro Thr Ser Leu Ala Thr Ala Ile Asp Pro Lys Gln Leu Gln Gln
1 5 10 15

Ala Ile Arg Ala Ser Gln Asp Phe Leu Phe Ser Gln Gln Tyr Ala Glu
20 25 30

Gly Tyr Trp Trp Ala Glu Leu Glu Ser Asn Val Thr Met Thr Ala Glu
35 40 45

Val Ile Leu Leu His Lys Ile Trp Gly Thr Glu Gln Arg Leu Pro Leu
50 55 60

Ala Lys Ala Glu Gln Tyr Leu Arg Asn His Gln Arg Asp His Gly Gly
65 70 75 80

Trp Glu Leu Phe Tyr Gly Asp Gly Gly Asp Leu Ser Thr Ser Val Glu
85 90 95

Ala Tyr Met Gly Leu Arg Leu Leu Gly Val Pro Glu Thr Asp Pro Ala
100 105 110

Leu Val Lys Ala Arg Gln Phe Ile Leu Ala Arg Gly Gly Ile Ser Lys
115 120 125

Thr Arg Ile Phe Thr Lys Leu His Leu Ala Leu Ile Gly Cys Tyr Asp
130 135 140

Trp Arg Gly Ile Pro Ser Leu Pro Pro Trp Ile Met Leu Leu Pro Glu
145 150 155 160

Gly Ser Pro Phe Thr Ile Tyr Glu Met Ser Ser Trp Ala Arg Ser Ser
165 170 175

Thr Val Pro Leu Leu Ile Val Met Asp Arg Lys Pro Val Tyr Gly Met
180 185 190

Asp Pro Pro Ile Thr Leu Asp Glu Leu Tyr Ser Glu Gly Arg Ala Asn
195 200 205

Val Val Trp Glu Leu Pro Arg Gln Gly Asp Trp Arg Asp Val Phe Ile
210 215 220

Gly Leu Asp Arg Val Phe Lys Leu Phe Glu Thr Leu Asn Ile His Pro
225 230 235 240

Leu Arg Glu Gln Gly Leu Lys Ala Ala Glu Glu Trp Val Leu Glu Arg
245 250 255

Gln Glu Ala Ser Gly Asp Trp Gly Gly Ile Ile Pro Ala Met Leu Asn
260 265 270

Ser Leu Leu Ala Leu Arg Ala Leu Asp Tyr Ala Val Asp Asp Pro Ile
275 280 285

Val Gln Arg Gly Met Ala Ala Val Asp Arg Phe Ala Ile Glu Thr Glu
290 295 300

Thr Glu Tyr Arg Val Gln Pro Cys Val Ser Pro Val Trp Asp Thr Ala
305 310 315 320

Leu Val Met Arg Ala Met Val Asp Ser Gly Val Ala Pro Asp His Pro
325 330 335

Ala Leu Val Lys Ala Gly Glu Trp Leu Leu Ser Lys Gln Ile Leu Asp
340 345 350

Tyr Gly Asp Trp His Ile Lys Asn Lys Lys Gly Arg Pro Gly Gly Trp
355 360 365

Ala Phe Glu Phe Glu Asn Arg Phe Tyr Pro Asp Val Asp Asp Thr Ala
370 375 380

Val Val Val Met Ala Leu His Ala Val Thr Leu Pro Asn Glu Asn Leu
385 390 395 400

Lys Arg Arg Ala Ile Glu Arg Ala Val Ala Trp Ile Ala Ser Met Gln
405 410 415

Cys Arg Pro Gly Gly Trp Ala Ala Phe Asp Val Asp Asn Asp Gln Asp
420 425 430

Trp Leu Asn Gly Ile Pro Tyr Gly Asp Leu Lys Ala Met Ile Asp Pro
435 440 445

Asn Thr Ala Asp Val Thr Ala Arg Val Leu Glu Met Val Gly Arg Cys
450 455 460

Gln Leu Ala Phe Asp Arg Val Ala Leu Asp Arg Ala Leu Ala Tyr Leu
465 470 475 480

Arg Asn Glu Gln Glu Pro Glu Gly Cys Trp Phe Gly Arg Trp Gly Val
485 490 495

Asn Tyr Leu Tyr Gly Thr Ser Gly Val Leu Thr Ala Leu Ser Leu Val
500 505 510

Ala Pro Arg Tyr Asp Arg Trp Arg Ile Arg Arg Ala Ala Glu Trp Leu
515 520 525

Met Gln Cys Gln Asn Ala Asp Gly Gly Trp Gly Glu Thr Cys Trp Ser
530 535 540

Tyr His Asp Pro Ser Leu Lys Gly Lys Gly Asp Ser Thr Ala Ser Gln
545 550 555 560

Thr Ala Trp Ala Ile Ile Gly Leu Leu Ala Ala Gly Asp Ala Thr Gly
565 570 575

Asp Tyr Ala Thr Glu Ala Ile Glu Arg Gly Ile Ala Tyr Leu Leu Glu
580 585 590

Thr Gln Arg Pro Asp Gly Thr Trp His Glu Asp Tyr Phe Thr Gly Thr
595 600 605

Gly Phe Pro Cys His Phe Tyr Leu Lys Tyr His Tyr Tyr Gln Gln His
610 615 620

Phe Pro Leu Thr Ala Leu Gly Arg Tyr Ala Arg Trp Arg Asn Leu Leu
625 630 635 640

Ala Thr


<210> 249
<211> 632
<212> PRT
<213> Trichodesmium erythraeum

<400> 249
Met Ile Glu Lys Asn Lys Val Lys Gln Ser Ile Leu Ala Ser Gln Lys
1 5 10 15

His Leu Leu Ser Leu Gln Glu Thr Glu Gly Tyr Trp Trp Gly Gln Leu
20 25 30

Glu Ser Asn Val Thr Ile Thr Ala Glu Ile Ile Leu Leu His Lys Ile
35 40 45

Trp Gln Thr Asp Lys Lys Ile Pro Leu Asn Lys Ala Lys Asn Tyr Leu
50 55 60

Ile Ser Gln Gln Arg Glu His Gly Gly Trp Glu Leu Phe Tyr Gly Asp
65 70 75 80

Gly Gly Asp Leu Ser Thr Ser Ile Glu Ala Tyr Met Ala Leu Arg Leu
85 90 95

Leu Gly Val Ser Arg Thr Asp Pro Ile Met Ile Glu Ala Gln Asn Phe
100 105 110

Ile Ile Lys Lys Gly Gly Ile Ser Cys Ser Arg Ile Phe Thr Lys Leu
115 120 125

His Leu Ala Leu Ile Gly Cys Tyr Ser Trp Gln Gly Ile Pro Ser Ile
130 135 140

Pro Ser Ser Ile Met Leu Leu Pro Glu Asp Phe Pro Phe Thr Ile Tyr
145 150 155 160

Glu Met Ser Ser Trp Ala Arg Ser Ser Thr Val Pro Leu Leu Ile Val
165 170 175

Phe Asp Lys Lys Pro Ile Phe Ser Val Asn Pro Thr Ile Asn Leu Asp
180 185 190

Glu Leu Tyr Ala Glu Gly Ile Asn Asn Ala Ser Phe Glu Leu Pro Arg
195 200 205

Lys Tyr Asp Leu Thr Asp Leu Phe Leu Gly Leu Asp Lys Ala Phe Lys
210 215 220

Phe Ala Glu Asn Leu Asn Leu Met Pro Leu Gln Gln Glu Gly Leu Lys
225 230 235 240

Ala Ala Glu Lys Trp Ile Leu Glu Arg Gln Glu Val Thr Gly Asp Trp
245 250 255

Gly Gly Ile Ile Pro Ala Met Leu Asn Ser Met Leu Ala Leu Lys Cys
260 265 270

Leu Glu Tyr Asp Val Ala Asp Pro Val Val Val Arg Gly Leu Glu Ala
275 280 285

Ile Asp Arg Phe Ala Ile Glu Asn Glu Asp Ser Tyr Arg Val Gln Ala
290 295 300

Cys Val Ser Pro Val Trp Asp Thr Ala Trp Val Ile Arg Ser Leu Val
305 310 315 320

Asp Ser Gly Ile Ser Pro Ser His Pro Ala Met Val Lys Ala Gly Gln
325 330 335

Trp Leu Leu Gln Gln Gln Ile Leu Asp Tyr Gly Asp Trp Val Phe Lys
340 345 350

Asn Lys Phe Gly Lys Pro Gly Gly Trp Ala Phe Glu Phe Met Asn Arg
355 360 365

Phe Tyr Pro Asp Ile Asp Asp Thr Ala Val Val Val Met Ala Leu Asp
370 375 380

Val Val Glu Leu Pro Asp Glu Asp Leu Lys Gly Lys Ala Ile Ala Arg
385 390 395 400

Gly Met Glu Trp Ile Ala Ser Met Gln Cys Glu Ala Gly Gly Trp Ala
405 410 415

Ala Phe Asp Val Asp Asn Asn Gln Asp Trp Leu Asn Ala Thr Pro Tyr
420 425 430

Gly Asp Leu Lys Ala Met Ile Asp Pro Asn Thr Ala Asp Val Thr Gly
435 440 445

Arg Val Leu Glu Met Val Gly Cys Cys Gly Leu Ala Met Asp Ser Trp
450 455 460

Arg Val Lys Arg Gly Ile Asp Phe Leu Val Arg Glu Gln Glu Glu Glu
465 470 475 480

Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Ser
485 490 495

Gly Val Ile Leu Ala Leu Ala Val Met Ala Arg Glu Ser His Arg Gly
500 505 510

Tyr Ile Glu Arg Gly Ala Ser Trp Leu Val Gly Cys Gln Asn Ser Asp
515 520 525

Gly Gly Trp Gly Glu Ser Cys Trp Ser Tyr Asn Asp Pro Ser Leu Lys
530 535 540

Gly Lys Gly Lys Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Ile Gly
545 550 555 560

Leu Leu Ala Ala Gly Glu Gly Thr Gly Asn Phe Ala Arg Asp Ala Ile
565 570 575

Asp Gly Gly Val Gly Phe Leu Val Ser Thr Gln Asn Asp Asp Gly Ser
580 585 590

Trp Leu Glu Asp Glu Phe Thr Gly Thr Gly Phe Pro Gly His Phe Tyr
595 600 605

Ile Lys Tyr His Phe Tyr Ser Gln Tyr Phe Pro Leu Met Ala Leu Gly
610 615 620

Arg Tyr Glu Ser Leu Leu Ser Gly
625 630


<210> 250
<211> 233
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 250
Ser Pro Met Trp Asp Thr Val Leu Thr Thr Leu Ala Val Gln Asp Ala
1 5 10 15

Gly Val Asp Gln Glu Pro Glu Phe Lys Pro Ala Met Glu Arg Thr Leu
20 25 30

Glu Trp Leu Leu Lys Asn Glu Val Arg Thr Gly Gly Asp Trp Gln Gln
35 40 45

Lys Thr Arg Gly Val Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn
50 55 60

Ala Ser Tyr Pro Asp Asn Asp Asp Thr Ala Val Ala Leu Ile Val Leu
65 70 75 80

Ala Pro Phe Arg His Asp Pro Lys Trp Gln Ala Arg Gly Ile Gln His
85 90 95

Val Ile Asp Arg Ala Val Asn Trp Met Phe Ala Met Gln Cys Asp Asn
100 105 110

Gly Gly Trp Ala Ala Phe Asp Leu Asp Asn Asp Lys Ala Ile Leu Thr
115 120 125

Arg Ile Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val
130 135 140

Asp Val Thr Ala His Val Leu Glu Ala Leu Ala Ala Leu Gly Tyr Ser
145 150 155 160

Arg Glu His Pro Ala Val Arg Arg Ala Ile Ala Phe Leu Lys Glu Asp
165 170 175

Gln Glu Pro Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Phe Ile
180 185 190

Tyr Gly Thr Ala Ala Ala Leu Pro Ala Leu Lys Ala Met Asp Glu Asp
195 200 205

Met Thr Gln Asp Trp Ile Thr Arg Ala Ala Asp Trp Met Arg Ser Arg
210 215 220

Gln Asn Asp Asp Gly Gly Trp Gly Glu
225 230


<210> 251
<211> 233
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<400> 251
Ser Pro Val Trp Asp Thr Val Leu Thr Met Leu Ser Val Gln Asp Cys
1 5 10 15

Asp Ala Asp Glu Asn Ser Glu Asn Ala Pro Ala Ile Glu Lys Ala Ile
20 25 30

Glu Trp Leu Leu Ala Asn Glu Val Arg Thr Gly Gly Asp Trp Gln Glu
35 40 45

Lys Val Lys Gly Val Glu Pro Gly Gly Trp Ala Phe Glu Tyr Lys Asn
50 55 60

Ala Ser Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Met Met Ala Leu
65 70 75 80

Ala Pro Tyr Arg Thr Glu Glu Lys Trp Lys Lys Lys Gly Leu Pro Glu
85 90 95

Ala Leu Lys Arg Ala Ala Glu Trp Asn Ile Ala Met Gln Cys Ser Asn
100 105 110

Gly Gly Trp Gly Ala Phe Asp Lys Asp Asn Asp Lys Thr Ile Leu Cys
115 120 125

Lys Ile Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val
130 135 140

Asp Val Thr Ala His Val Leu Glu Gly Leu Ala Ala Leu Asp Tyr Pro
145 150 155 160

Pro Glu His Pro Ala Ile Gln Arg Ala Val Gln Phe Ile Lys Asp Glu
165 170 175

Gln Glu Pro Asp Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Phe Ile
180 185 190

Tyr Gly Thr Ala Ala Ala Leu Pro Ala Leu Lys Ala Val Gly Glu Asp
195 200 205

Met Arg Ala Pro Tyr Ile Asp Arg Ala Ala Lys Trp Ile Val Asp His
210 215 220

Gln Asn Glu Asp Gly Gly Trp Gly Glu
225 230


<210> 252
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<400> 252
Ser Pro Val Trp Asp Thr Val Leu Thr Leu Leu Ala Leu Asp Asp Cys
1 5 10 15

Gly Tyr Asn Asp Cys Tyr Ser Glu Glu Val Asp Lys Ala Val Gln Trp
20 25 30

Val Leu Asp Gln Gln Val Leu Ser Lys Gly Asp Trp Ser Val Lys Leu
35 40 45

Pro Asn Val Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn Thr Arg
50 55 60

Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ser Gln
65 70 75 80

Phe Lys Asp Asp Pro Lys Trp Lys Glu Arg Gly Ile Asn Gln Ala Ile
85 90 95

Glu Arg Gly Val Asn Trp Leu Phe Glu Met Gln Cys Lys Asn Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Lys Thr Leu Leu Thr Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val
130 135 140

Thr Ala His Ile Val Glu Ala Phe Gly Lys Leu Gly Tyr Ser Lys Asp
145 150 155 160

His Pro Lys Ile Ala His Ala Ile Glu Tyr Leu Lys Glu Glu Gln Glu
165 170 175

Ala Asp Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly
180 185 190

Thr Gly Ala Val Leu Pro Ala Leu Glu Ala Ile Gly Glu Asp Met Ser
195 200 205

Gln Pro Tyr Ile Arg Lys Ala Ala Asn Trp Leu Val Leu His Gln Asn
210 215 220

Glu Asp Gly Gly Trp Gly Glu
225 230


<210> 253
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<400> 253
Ser Pro Val Trp Asp Thr Val Leu Thr Leu Leu Ala Phe Asp Asp Cys
1 5 10 15

Asp Lys Asn Glu Ala Tyr Gln Ala Ser Val Glu Lys Ala Val Gln Trp
20 25 30

Thr Leu Asp Asn Gln Val Leu Arg Lys Gly Asp Trp Ser Val Lys Leu
35 40 45

Pro Asp Val Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn Thr Phe
50 55 60

Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ser Gln
65 70 75 80

Phe Arg Asp Val Glu Lys Trp Gln Glu Ala Gly Ile Glu Lys Ala Ile
85 90 95

Glu Arg Gly Val Asn Trp Leu Phe Ala Met Gln Ser Lys Asn Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Asn Asn Phe Ile Thr Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val
130 135 140

Thr Ala His Cys Ile Glu Ala Phe Gly Lys Leu Gly Leu Ser Arg Ala
145 150 155 160

Arg Pro Glu Ile Ala Arg Gly Leu Asp Tyr Leu Lys Ser Glu Gln Glu
165 170 175

Ala Asp Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly
180 185 190

Thr Gly Ala Val Leu Pro Ala Leu Glu Ala Ile Gly Glu Asp Met Ser
195 200 205

Gln Pro Tyr Ile Arg Lys Ala Ala Asn Trp Leu Ile Leu Arg Gln Asn
210 215 220

Glu Asp Gly Gly Trp Gly Glu
225 230


<210> 254
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (36)..(36)
<223> Xaa can be any amino acid

<400> 254
Ser Pro Val Trp Asp Thr Leu Leu Thr Leu Leu Ala Tyr Asp Asp Ser
1 5 10 15

Gly Gln Asn Glu Arg Lys Ala Asp Glu Val Glu Lys Ala Val Asp Trp
20 25 30

Val Leu Ala Xaa Gln Val Leu Arg Pro Gly Asp Trp Lys Val Lys Ala
35 40 45

Pro Asn Leu Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn Tyr Phe
50 55 60

Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ser Gln
65 70 75 80

Phe Arg Asn Asp Ala Ala Trp Lys Glu Lys Gly Ile Glu Gln Ala Ile
85 90 95

Glu Lys Gly Val Asn Trp Leu Phe Gly Met Gln Cys Lys Gly Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Lys Gln Phe Leu Thr Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val
130 135 140

Thr Ala His Ile Val Glu Ala Phe Gly Lys Leu Lys Phe Ser Lys Asp
145 150 155 160

His Pro Asn Ile Arg Arg Ala Ile Asp Tyr Met Lys Asp Glu Gln Glu
165 170 175

Ala Asp Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Gly Ala Val Leu Pro Ala Leu Glu Ala Ile Gly Glu Asp Met Phe
195 200 205

Ala Pro Cys Ile Gly Arg Ala Cys Asp Trp Leu Val Ser Arg Gln Asn
210 215 220

Asp Asp Gly Gly Trp Gly Glu
225 230


<210> 255
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 255
Ser Pro Val Trp Asp Thr Leu Leu Thr Leu Leu Ala Tyr Asp Asn Ser
1 5 10 15

Gly His Asn Ala Arg Lys Ala Ser Glu Val Glu Lys Ala Val Asp Trp
20 25 30

Val Leu Ala Gln Gln Val Leu Arg Pro Gly Asp Trp Asn Val Lys Ala
35 40 45

Pro Asn Leu Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn Tyr Phe
50 55 60

Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ser Gln
65 70 75 80

Phe Arg Asn Asp Ala Ala Trp Lys Asp Lys Gly Ile Glu Gln Ala Ile
85 90 95

Glu Lys Gly Val Asn Trp Leu Phe Gly Met Gln Cys Lys Gly Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Arg Gln Phe Leu Thr Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val
130 135 140

Thr Ala His Ile Val Glu Ala Phe Gly Lys Leu Lys Phe Ser Lys Asp
145 150 155 160

His Pro Asn Ile Arg Arg Ala Ile Asp Tyr Thr Lys Asp Glu Gln Glu
165 170 175

Asp Asp Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Gly Ala Val Leu Leu Ala Leu Glu Ala Ile Gly Glu Asp Met Ser
195 200 205

Ala Pro Tyr Ile Gly Arg Ala Cys Asp Trp Leu Val Ser Arg Gln Asn
210 215 220

Asp Asp Gly Gly Trp Gly Glu
225 230


<210> 256
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (180)..(180)
<223> Xaa can be any amino acid

<400> 256
Ser Pro Val Trp Asp Thr Leu Leu Thr Leu Leu Ala Ile Glu Asp Ser
1 5 10 15

Gly Gln Ser Val Lys Arg Ala Gln Glu Val Glu Lys Ala Val Asp Trp
20 25 30

Val Leu Ser Gln Gln Val Leu Arg Pro Gly Asp Trp Lys Val Arg Ala
35 40 45

Pro His Leu Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn Tyr Phe
50 55 60

Phe Pro Asp Thr Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ser Gln
65 70 75 80

Phe Arg Asn Asp Ala Ala Trp Lys Ala Lys Gly Ile Glu Thr Ala Ile
85 90 95

Glu Lys Gly Val Asn Trp Leu Leu Gly Met Gln Cys Lys Gly Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Lys Thr Tyr Leu Thr Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val
130 135 140

Thr Ala His Ile Val Glu Ala Phe Gly Lys Leu Gly Phe Ser Lys Asp
145 150 155 160

His Pro Asn Ile Ala Arg Ala Ile Glu Tyr Leu Lys Ser Glu Gln Glu
165 170 175

Ser Asp Gly Xaa Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly
180 185 190

Val Gly Ala Val Leu Pro Ala Leu Glu Ala Ile Gly Glu Asp Met Ser
195 200 205

Ala Pro Tyr Ile Gly Arg Ala Cys Asp Trp Leu Val Ser Lys Gln Asn
210 215 220

Ser Asp Gly Gly Trp Gly Glu
225 230


<210> 257
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (7)..(7)
<223> Xaa can be any amino acid

<400> 257
Ser Pro Val Trp Asp Thr Xaa Leu Thr Leu Leu Ala Leu Asp Asp Cys
1 5 10 15

Asp Leu Asn Glu Arg Gln Ser Lys Glu Val Glu Lys Ala Val Gln Trp
20 25 30

Val Leu Asn Gln Gln Val Leu Arg Pro Gly Asp Trp Cys Val Lys Val
35 40 45

Pro Lys Val Gln Pro Gly Gly Trp Ala Phe Glu Tyr Lys Asn Tyr Phe
50 55 60

Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ser Gln
65 70 75 80

Phe Arg Asp Asp Pro Lys Trp Gln Glu Lys Asn Ile Glu Gln Ala Ile
85 90 95

Asp Arg Gly Leu Asn Trp Leu Ile Gly Met Gln Cys Lys Gly Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Lys Thr Tyr Leu Thr Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Ser Pro Ser Val Asp Val
130 135 140

Thr Ala His Ile Val Glu Ala Phe Gly Lys Leu Gly Leu Gly Lys Ser
145 150 155 160

His Pro Ala Met Ile Arg Ala Ile Asp Tyr Leu Lys Ala Glu Gln Glu
165 170 175

Gln Asp Gly Ala Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Gly Ala Val Leu Pro Ala Leu Glu Ala Ile Gly Glu Asp Met Arg
195 200 205

Ala Pro Tyr Ile Ala Lys Ala Cys Asp Trp Leu Ile Ala Val Gln Gln
210 215 220

Glu Asp Gly Gly Trp Gly Glu
225 230


<210> 258
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 258
Ser Pro Val Trp Asp Thr Val Leu Thr Met Leu Ala Ile His Asp Cys
1 5 10 15

Gly Ala Asp Lys Gln Tyr Ala Pro Gln Met Asp Lys Ala Ile Asp Trp
20 25 30

Leu Leu Ala Asn Glu Val Arg His Lys Gly Asp Trp Ala Val Lys Leu
35 40 45

Pro Asp Val Glu Pro Gly Gly Trp Ala Phe Glu Tyr Ser Asn Ala Cys
50 55 60

Tyr Pro Asp Leu Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ala Pro
65 70 75 80

Tyr Arg Asn Asp Pro Lys Trp Gln Ala Arg Asp Ile Glu Gly Ala Val
85 90 95

Glu Arg Ala Val Asp Trp Thr Leu Ala Met Gln Cys Lys Asn Gly Gly
100 105 110

Trp Gly Ala Phe Gly Lys Asp Asn Asp Lys Ala Ile Leu Thr Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val
130 135 140

Thr Ala His Val Leu Glu Ala Leu Ala Ala Leu Gly Tyr Asp Asn Ser
145 150 155 160

His Pro Ala Val Ala Arg Ala Ile Arg Tyr Leu Arg Asp Glu Gln Glu
165 170 175

Pro Asp Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Ala Ala Val Leu Pro Ala Leu Lys Ala Met Gly Val Asp Met Asn
195 200 205

Glu Pro Phe Val His Lys Ala Ala Asp Trp Ile Gly Ser Val Gln Asn
210 215 220

Glu Asp Gly Gly Trp Gly Glu
225 230


<210> 259
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 259
Ser Pro Val Trp Asp Thr Val Leu Thr Leu Leu Ala Met Glu Asp Cys
1 5 10 15

Glu Ala Thr Glu Glu His Ala Ala Ala Ile Glu Gln Ala Ile Glu Trp
20 25 30

Leu Leu Glu Asn Glu Val Arg Thr Pro Gly Asp Trp Gln Met Lys Val
35 40 45

Pro Asp Ala Asp Pro Gly Gly Trp Ala Phe Glu Tyr Ala Asn Ala Ala
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ala Val Ala Ile Leu Val Leu Ala Arg
65 70 75 80

Tyr Arg Asp Asp Pro Lys Trp Gln Ala Lys Gly Leu Pro Gln Ala Ile
85 90 95

Asp Arg Ala Val Ala Trp Val Leu Ala Met Gln Cys Ser Asn Gly Gly
100 105 110

Trp Ala Ala Phe Asp Lys Asp Asn Asp Lys Ser Ile Leu Cys Lys Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Ala Thr Val Asp Val
130 135 140

Thr Ala His Val Leu Glu Ala Leu Ala Ala Val Gly Tyr Gly Pro Asp
145 150 155 160

His Pro Ala Val Arg Arg Gly Leu Asp Phe Leu Tyr Ala Glu Gln Glu
165 170 175

Ala Asp Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly
180 185 190

Thr Gly Ala Ala Leu Pro Ala Phe Lys Ala Ile Gly Ala Asp Met Arg
195 200 205

Asp Pro Arg Met Leu Lys Ala Ala Asp Trp Ile Leu Arg Cys Gln Asn
210 215 220

Lys Asp Gly Gly Trp Gly Glu
225 230


<210> 260
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (133)..(133)
<223> Xaa can be any amino acid

<400> 260
Ser Pro Val Trp Asp Thr Val Leu Thr Leu Leu Ala Ile Gln Asp Ala
1 5 10 15

Asp Lys Gln Asp Asp Met Ala Ala Glu Val Asp Arg Ala Ile Gly Trp
20 25 30

Leu Leu Ser Lys Glu Val Arg Thr Asn Gly Asp Trp Ser Val Lys Leu
35 40 45

Pro Asp Val Glu Pro Gly Gly Trp Ala Phe Glu His Glu Asn Ala Arg
50 55 60

Tyr Pro Asp Thr Asp Asp Thr Ala Val Ala Val Met Val Leu Ala Pro
65 70 75 80

Tyr Arg His His Pro Lys Trp Arg Lys Arg Gly Leu Pro Glu Ala Leu
85 90 95

Asp Arg Ala Ile Ser Trp Met Arg Ala Met Gln Cys Arg Asn Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Asn Ala Phe Leu Cys Val Ile
115 120 125

Pro Phe Cys Asp Xaa Gly Glu Ala Leu Asp Pro Pro Ser Ile Asp Val
130 135 140

Thr Ala His Ala Leu Glu Ala Phe Ala Ala Met Gly Phe Gly Pro Glu
145 150 155 160

Asp Thr Thr Val Ala Arg Ala Leu Asp Tyr Met Ser Lys Glu Gln Glu
165 170 175

Ala Asp Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Ala Ala Ala Leu Pro Ala Tyr Lys Ala Phe Gly Gln Asp Met Arg
195 200 205

Asp Pro Lys Leu Met Lys Ala Ala Asp Tyr Leu Arg Ala Lys Gln Asn
210 215 220

Ala Asp Gly Gly Trp Gly Glu
225 230


<210> 261
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 261
Ser Pro Val Trp Asp Thr Val Leu Thr Leu Leu Ala Ile Gln Asp Ala
1 5 10 15

Asp Lys Gln Glu Glu Met Ala Gly Glu Ile Asp Lys Ala Ile Gly Trp
20 25 30

Leu Leu Ser Lys Glu Val Arg Thr Lys Gly Asp Trp Ser Val Lys Leu
35 40 45

Pro Arg Val Glu Pro Gly Gly Trp Ala Phe Glu His Glu Asn Ala Arg
50 55 60

Tyr Pro Asp Ile Asp Asp Thr Ala Val Ala Ile Met Val Leu Ala Pro
65 70 75 80

Tyr Arg Asp His Pro Lys Trp Lys Lys Arg Gly Leu Pro Glu Ala Leu
85 90 95

Asp Arg Ala Ile Ala Trp Met Arg Ala Met Gln Cys Arg Gly Gly Gly
100 105 110

Trp Gly Ala Phe Asp Lys Asp Asn Asp Lys Gln Ile Leu Cys Thr Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Ile Asp Val
130 135 140

Thr Ala Tyr Ala Leu Glu Ala Phe Ala Ala Met Gly Tyr Gly Pro Asp
145 150 155 160

Asp Lys Thr Val Ala Arg Ala Leu Lys Tyr Met Ser Lys Glu Gln Glu
165 170 175

Ala Asp Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Ala Ala Ala Leu Pro Ala Tyr Lys Ala Leu Gly Gln Asp Met Arg
195 200 205

Asp Pro Gly Leu Met Lys Ala Ala Asp Tyr Leu Arg Asp Lys Gln Asn
210 215 220

Ala Asp Gly Gly Trp Gly Glu
225 230


<210> 262
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 262
Ser Pro Val Trp Asp Thr Val Leu Thr Leu Leu Ala Met Gln Asp Ala
1 5 10 15

Asp Arg Thr Asp Lys His Lys Ala Ala Val Asp Lys Ala Ile Gln Trp
20 25 30

Val Leu Asp Gln Glu Val Arg Thr Pro Gly Asp Trp Cys Val Gln Thr
35 40 45

Pro Asp Val Glu Pro Gly Gly Trp Ala Phe Glu Tyr Glu Asn Ala Arg
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ala Val Ala Ile Met Val Leu Ala Pro
65 70 75 80

Tyr Gln Asp Asp Pro Lys Trp Arg Lys Arg Gly Leu Pro Asp Ala Leu
85 90 95

Ala Arg Ala Ile Ala Trp Ile Arg Ala Met Gln Cys Lys Asn Gly Gly
100 105 110

Trp Gly Ala Phe Asp Arg Asp Asn Asp Asn Ser Met Leu Thr Val Ile
115 120 125

Pro Phe Cys Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Val Asp Val
130 135 140

Thr Ala His Ala Leu Glu Ala Phe His Met Met Gly Tyr Gly Pro Glu
145 150 155 160

Asp Pro Thr Val Ala Arg Ala Leu Ala Tyr Leu Asp Ala Glu Gln Glu
165 170 175

Gln Asp Gly Ser Trp Trp Gly Arg Trp Gly Val Asn Phe Ile Tyr Gly
180 185 190

Thr Ser Ala Ala Leu Pro Ala Leu Lys Ala Met Gly Arg Asp Met Arg
195 200 205

Asp Pro Arg Tyr Thr Lys Ala Ala Asp Tyr Leu Arg Ala Val Gln Asn
210 215 220

Asp Asp Gly Gly Trp Gly Glu
225 230


<210> 263
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 263
Ser Pro Val Trp Asp Thr Ser Leu Ile Leu Asn Ala Leu Leu Ala Gly
1 5 10 15

Ser Glu Lys Thr Glu Thr Asp Pro Lys Ile Leu Lys Ala Gly Gln Trp
20 25 30

Leu Leu Asp Arg Glu Val Arg Glu Ile Gly Asp Trp Lys Ile Lys Asn
35 40 45

Asn Arg Gly Pro Val Gly Gly Trp Tyr Phe Glu Tyr Ala Asn Glu Phe
50 55 60

Tyr Pro Asp Cys Asp Asp Thr Ala Glu Val Ile Thr Val Leu Asn Gln
65 70 75 80

Met Gln Phe Ser Asp Pro Glu Lys Glu Lys Ala Lys Gln Val Ala Gln
85 90 95

Gln Arg Gly Leu Asp Trp Leu Leu Ser Met Gln Asn Lys Asp Gly Gly
100 105 110

Trp Pro Ala Phe Asp Lys Asn Cys Asp Lys Gln Ser Leu Thr Tyr Met
115 120 125

Pro Phe Ala Asp His Asn Ala Met Ile Asp Pro Ser Tyr Glu Asp Ile
130 135 140

Thr Gly Arg Thr Leu Glu Ala Leu Ala Ser Leu Gly Phe Ser Glu Asp
145 150 155 160

Asp Pro Ile Val Arg Arg Ala Val Asp Phe Leu Lys Ser Lys Gln Leu
165 170 175

Pro Asp Gly Thr Trp Tyr Gly Arg Trp Gly Cys Asn Phe Leu Tyr Gly
180 185 190

Thr Trp Leu Ala Ile Ser Gly Leu Tyr His Ala Gly Glu Asp Leu Asn
195 200 205

Glu Glu Arg Tyr Gln Ser Leu Leu Ser Trp Leu Glu Gln Cys Gln Asn
210 215 220

Glu Asp Gly Gly Trp Gly Glu
225 230


<210> 264
<211> 230
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 264
Ser Pro Val Trp Asp Thr Leu Leu Thr Leu Glu Ala Leu Leu Asp Cys
1 5 10 15

Asn Leu Ser Pro Lys Thr Phe Thr Gly Met Gln Ala Ala Val Asp Trp
20 25 30

Ile Leu Ser Lys Gln Ile Val Thr Pro Gly Asp Trp Gln Ile Lys Val
35 40 45

Pro Gly Val Ser Cys Gly Gly Trp Ala Phe Glu Arg Ala Asn Thr Phe
50 55 60

Tyr Pro Asp Met Asp Asp Thr Ala Val Ala Met Ile Val Leu Ala Arg
65 70 75 80

Ile Arg Arg Tyr Tyr Asn Asp Ser Ser Arg Ile Asp Arg Ala Leu Ala
85 90 95

Cys Ala Thr Asp Trp Ile Leu Ser Met Gln Cys Ser Asn Gly Gly Trp
100 105 110

Ala Ala Phe Asp Leu Asp Asn Thr Asn Asp Leu Val Thr Arg Ile Pro
115 120 125

Phe Ser Asp Phe Gly Glu Met Leu Asp Pro Pro Ser Val Asp Val Thr
130 135 140

Ala His Val Val Glu Ala Leu Gly Cys Leu Gly Arg Thr Arg Asn Asp
145 150 155 160

Pro Ala Val Ala Arg Ala Val Ala Tyr Ile Leu Asp Glu Gln Glu Pro
165 170 175

Glu Gly Ser Trp Phe Gly Arg Trp Gly Val Asn His Ile Tyr Gly Thr
180 185 190

Gly Ala Val Leu Pro Ala Leu Ala Ala Val Gly Thr Asp Met Ser Ala
195 200 205

Gly Tyr Ile Thr Arg Ala Ala Asp Trp Val Ala Thr His Gln Asn Ala
210 215 220

Asp Gly Gly Trp Gly Glu
225 230


<210> 265
<211> 230
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 265
Ser Pro Val Trp Asp Thr Thr Asn Ala Met Thr Ala Val Leu Asp Ala
1 5 10 15

Gly Leu Pro Gly Asn His Pro Ala Val Leu Arg Ala Ala Arg Trp Leu
20 25 30

Leu Ser Lys Glu Val Arg Met Pro Gly Asp Trp Arg Leu Trp Tyr Lys
35 40 45

Asn Gly Glu Pro Gly Gly Trp Phe Phe Glu Tyr Asn Asn Glu Phe Tyr
50 55 60

Pro Asp Ala Asp Asp Thr Ala Glu Ala Leu His Cys Leu Cys Arg Val
65 70 75 80

Val Phe Asp Cys Glu Asp Glu Met Asp Arg Cys Arg Ala Ala Ile Lys
85 90 95

Arg Gly Leu Asn Trp Gln Phe Ala Cys Gln Asn Pro Asp Gly Gly Trp
100 105 110

Pro Ala Phe Asp Lys Glu Cys Asp Asp Glu Tyr Leu Thr Phe Ile Pro
115 120 125

Phe Ala Asp His Asn Ala Met Ile Asp Pro Ser Cys Cys Asp Ile Thr
130 135 140

Gly Arg Ser Leu Gln Ala Leu Ser Lys Leu Gly Tyr Thr Thr Asn Asp
145 150 155 160

Val Asp Val Lys Arg Ala Ile Asp Tyr Leu Leu Asp Ala Gln Glu Asp
165 170 175

Asp Gly Thr Trp Tyr Gly Arg Trp Gly Ile Asn Tyr Ile Tyr Gly Thr
180 185 190

Trp Leu Ala Val Gln Gly Leu Arg Ala Ile Gly Val Asp Leu Ser Glu
195 200 205

Lys Arg Phe Gln Lys Val Thr Lys Trp Leu Arg Lys Lys Gln Asn Pro
210 215 220

Asp Gly Gly Trp Gly Glu
225 230


<210> 266
<211> 230
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (208)..(208)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (224)..(224)
<223> Xaa can be any amino acid

<400> 266
Ser Pro Ile Trp Asp Thr Gly Ile Val Leu His Ser Leu Val Glu Ser
1 5 10 15

Gly Val Ser Pro Asp His Glu Ala Leu Leu Arg Ser Val Ser Trp Leu
20 25 30

Leu Ala Lys Glu Val Thr His Glu Gly Asp Trp Lys Val Lys Cys Pro
35 40 45

Asp Ala Pro Val Gly Gly Trp Tyr Phe Glu Tyr Ala Asn Glu Phe Asn
50 55 60

Pro Asp Cys Asp Asp Thr Ala Lys Val Leu Met Ala Thr Ser Arg Phe
65 70 75 80

Ser Ser Val Asp Phe Pro Asp Ala Gly Arg Leu Arg Asp Ala Arg Asn
85 90 95

Arg Gly Leu Gln Trp Leu Leu His Met Gln Asn Lys Asp Gly Gly Trp
100 105 110

Ala Ala Phe Asp Lys Gly Cys Asp Asn Glu Leu Leu Thr Tyr Ile Pro
115 120 125

Phe Ala Asp His Asn Ala Met Ile Asp Pro Ser Thr Glu Asp Ile Thr
130 135 140

Gly Arg Val Leu Glu Thr Leu Ala Arg Glu Gly Phe Asp Asn Thr His
145 150 155 160

Pro Val Val Lys Arg Ala Ile Gln Tyr Leu His Lys Thr Gln Asp Ala
165 170 175

Glu Gly Pro Trp Tyr Gly Arg Trp Gly Ser Asn Phe Ile Tyr Gly Thr
180 185 190

Trp Leu Val Leu Gln Gly Leu Lys Ala Val Gly Glu Asp Met Thr Xaa
195 200 205

Pro Arg Tyr Gln Arg Ala Ala Asn Trp Leu Leu Asn Val Gln Asn Xaa
210 215 220

Asn Gly Ser Trp Gly Glu
225 230


<210> 267
<211> 230
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 267
Ser Pro Val Trp Asp Thr Ala Ile Ser Val Ile Ala Leu Ala Glu Ser
1 5 10 15

Gly Leu His Arg Gly His Pro Ser Leu Val Gln Ala Thr Glu Trp Leu
20 25 30

Val Ala Asn Glu Ile Arg Arg Gly Gly Asp Trp Gln Val Lys Asn Pro
35 40 45

Thr Ala Pro Ile Ser Gly Trp Ala Phe Glu Phe Lys Asn Asp Phe Tyr
50 55 60

Pro Asp Val Asp Asp Thr Ala Met Val Leu Leu Ala Leu Arg His Val
65 70 75 80

His Leu Tyr Asn Asp Asp Val Ser Gln Asp Arg Glu Lys Ser Tyr Leu
85 90 95

Arg Gly Leu Asn Trp Met Leu Ser Met Gln Cys Lys Asn Gly Gly Trp
100 105 110

Ala Ala Phe Asp Arg Asp Asn Val Lys Thr Ile Phe Glu Lys Ile Pro
115 120 125

Phe Ala Asp His Asn Ala Met Ile Asp Pro Pro Ser Val Asp Ile Thr
130 135 140

Gly Arg Val Leu Glu Leu Leu Gly Tyr Val Gly Tyr Asp Lys Ser Tyr
145 150 155 160

Pro Cys Val Thr Lys Ala Leu Glu Tyr Ile Lys Lys Asp Gln Glu Ala
165 170 175

Asp Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr
180 185 190

Trp Gln Val Leu Arg Gly Leu Ala Ala Ile Gly Glu Asp Met Gln Ser
195 200 205

Glu Tyr Val Gln Lys Ala Val Arg Trp Met Lys Ser Val Gln Asn Pro
210 215 220

Asp Gly Gly Trp Gly Glu
225 230


<210> 268
<211> 229
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (111)..(111)
<223> Xaa can be any amino acid

<400> 268
Ser Pro Val Trp Asp Thr Cys Leu Ile Leu Asn Ser Met Leu Glu His
1 5 10 15

Leu Glu Pro Asp His Pro Arg Val Gln Lys Ala Ala Glu Trp Leu Leu
20 25 30

Ser Lys Glu Val Thr Glu Pro Gly Asp Trp Gln Val Lys Cys Pro Glu
35 40 45

Ala Pro Val Gly Gly Trp Tyr Phe Glu Tyr Ala Asn Glu Phe Tyr Pro
50 55 60

Asp Cys Asp Asp Thr Ala Glu Val Leu Ala Ala Leu Gln Arg Val Gln
65 70 75 80

Phe Thr Asp Ala Asp Arg Glu Ala Gln Lys Arg Gly Ala Ile Gln Arg
85 90 95

Gly Leu Gly Trp Leu Leu Ala Met Gln Asn Gln Asp Gly Gly Xaa Ala
100 105 110

Ala Phe Asp Arg Glu Cys Thr Arg Glu Ala Leu Thr Tyr Val Pro Phe
115 120 125

Ala Asp His Asn Ala Met Ile Asp Pro Ser Asn Gly Asp Ile Thr Gly
130 135 140

Arg Val Leu Lys Ala Leu Asp Tyr Ala Gly Tyr Ser Pro Asp Asp Pro
145 150 155 160

Ile Val Arg Gly Gly Val Asp Phe Leu Leu Ala Asn Gln Glu Pro Asp
165 170 175

Gly Thr Trp Tyr Gly Arg Trp Gly Cys Asn His Leu Tyr Gly Ser Trp
180 185 190

Leu Val Val Trp Gly Leu Lys His Ala Gly Val Asn Leu Gln Gln Thr
195 200 205

Gln Phe Thr Gln Val Met Ser Trp Leu Glu Ser Cys Gln Asn Ala Asp
210 215 220

Gly Gly Trp Gly Glu
225


<210> 269
<211> 229
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 269
Ser Pro Val Trp Asp Thr Cys Leu Ile Leu Asn Ser Leu Leu Glu His
1 5 10 15

Leu Glu Pro Asp His Pro Arg Leu Gln His Ala Ala Glu Trp Leu Leu
20 25 30

Ser Lys Glu Val Thr Glu Pro Gly Asp Trp Gln Val Lys Cys Pro Glu
35 40 45

Ala Pro Ile Gly Gly Trp Tyr Phe Glu Tyr Ala Asn Glu Phe Tyr Pro
50 55 60

Asp Cys Asp Asp Thr Ala Glu Val Leu Ala Ala Leu Gln Arg Val Arg
65 70 75 80

Phe Ser Asp Ala Asp Arg Glu Ala Gln Lys His Ala Ala Ile Glu Arg
85 90 95

Gly Leu Gly Trp Leu Leu Ala Met Gln Asn Gly Asp Gly Gly Trp Ala
100 105 110

Ala Phe Asp Arg Glu Cys Thr Arg Glu Ala Leu Thr Tyr Val Pro Phe
115 120 125

Ala Asp His Asn Ala Met Ile Asp Pro Ser Asn Gly Asp Ile Thr Gly
130 135 140

Arg Val Leu Lys Ala Leu Asp Tyr Ser Gly Arg Ser Pro Gln Asp Pro
145 150 155 160

Val Val Gln Gly Gly Val His Phe Leu Leu Ala Asn Gln Glu Pro Asp
165 170 175

Gly Thr Trp Tyr Gly Arg Trp Gly Cys Asn His Leu Tyr Gly Ser Trp
180 185 190

Leu Ala Ile Trp Gly Leu Lys His Ala Gly Val Asp Ser Gln Gln Ser
195 200 205

Gln Phe Met Arg Leu Leu Ser Trp Leu Glu Ser Cys Gln Asn Pro Asp
210 215 220

Gly Gly Trp Gly Glu
225


<210> 270
<211> 229
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 270
Ser Pro Val Trp Asp Thr Ala Leu Ala Met Ser Ala Leu Leu Glu Gly
1 5 10 15

Asp Thr Ala Pro Asp Asp Glu Ala Leu Gln Arg Gly Cys Arg Trp Leu
20 25 30

Leu Gly Lys Glu Val Arg His Arg Gly Asp Trp Gln Val Asn Val Gly
35 40 45

Ala Glu Pro Gly Gly Trp Phe Phe Glu Tyr Glu Asn Glu Phe Tyr Pro
50 55 60

Asp Cys Asp Asp Thr Ala Glu Val Leu Ala Val Leu Glu Arg Val Arg
65 70 75 80

Leu Ser Asp Pro Glu Glu Asp Gln Arg Arg Arg Asp Ala Leu Asp Arg
85 90 95

Ala Leu Ala Trp Gln Leu Gly Met Gln Ser Thr Asn Gly Gly Trp Gly
100 105 110

Ala Phe Asp Lys Asp Cys Asp His Arg Ile Leu Glu Leu Val Pro Phe
115 120 125

Ala Asp His Asn Ala Met Ile Asp Pro Pro Thr Val Asp Val Thr Ser
130 135 140

Arg Ser Ile Glu Ala Ala Leu Ala Met Gly Val Pro Ala Ser Asp Ala
145 150 155 160

Ala Ile Arg Arg Ala Val Arg Phe Leu Tyr Ser Glu Gln Glu Ala Asp
165 170 175

Gly Ser Trp Tyr Gly Arg Trp Gly Ser Asn Tyr Leu Tyr Gly Thr Trp
180 185 190

Leu Ala Leu Cys Ala Leu Arg Ser Ala Gly Glu Asp Leu Thr Ser Pro
195 200 205

Ala Val Gln Arg Ala Val Glu Trp Leu Leu Ser Val Gln Gln Glu Asp
210 215 220

Gly Gly Trp Gly Glu
225


<210> 271
<211> 295
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (15)..(15)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (30)..(30)
<223> Xaa can be any amino acid

<400> 271
Ser Pro Val Trp Asp Thr Ala Ile Ser Val Ile Ser Leu Ala Xaa Ser
1 5 10 15

Gly Met Glu Arg Gly His Pro Ala Leu Val Arg Ala Ala Xaa Trp Leu
20 25 30

Met Ser Lys Glu Ile Lys Thr Ala Gly Asp Trp Lys Val Thr Asn Pro
35 40 45

Ala Gly Pro Val Gly Gly Trp Ala Phe Glu Phe Asn Asn Ala Phe Tyr
50 55 60

Pro Asp Ile Asp Asp Ser Ala Met Val Met Met Ala Leu Arg His Val
65 70 75 80

His Leu Asp Glu His Thr Ala His Arg Arg Glu Lys Ala Cys Leu Arg
85 90 95

Gly Leu Asn Trp Leu Leu Ser Met Gln Ser Arg Thr Gly Gly Trp Ala
100 105 110

Ala Phe Asp Lys Asp Asn Thr Lys Val Ile Met Thr Lys Ile Pro Phe
115 120 125

Ala Asp His Asn Ala Met Ile Asp Pro Pro Trp Ala Asp Ile Thr Gly
130 135 140

Arg Val Leu Glu Phe Leu Gly Tyr Ile Gly Tyr Asp Gln Ser Tyr Pro
145 150 155 160

Ala Val Ala Arg Ala Ala Arg Phe Leu Arg Glu Glu Gln Glu Glu Asp
165 170 175

Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp
180 185 190

Gln Val Leu Arg Gly Leu Ala Ala Ile Asp Glu Asp Met Ser Gln Pro
195 200 205

Tyr Ile Arg Arg Ala Ala Glu Trp Leu Arg Ser Val Gln Pro Pro Asp
210 215 220

Gly Gly Trp Gly Glu Thr Cys Ala Thr Tyr His Asp Pro Ser Leu Lys
225 230 235 240

Gly Lys Gly Pro Ala Thr Pro Ala Gln Thr Ala Trp Ala Val Met Gly
245 250 255

Leu Met Ala Ala Gly Ile Tyr Asp Glu Ser Val Ser Arg Gly Ile Asp
260 265 270

Tyr Leu Val Arg Thr Gln Arg Pro Asp Gly Thr Trp Asp Glu Thr Glu
275 280 285

Tyr Thr Gly Thr Gly Phe Pro
290 295


<210> 272
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 272
Ser Pro Val Trp Asp Thr Gly Leu Val Ala Leu Ala Leu Gln Glu Val
1 5 10 15

Asp Lys His Asn Ser Gln Asp Ala Leu Gln Arg Asn Leu Lys Gln Ala
20 25 30

Tyr Ser Trp Leu Leu Ser Lys Gln Leu Lys Asp Glu Pro Gly Asp Trp
35 40 45

Arg Ile Ser Lys Pro Thr Leu Thr Gly Gly Gly Trp Ala Phe Gln Phe
50 55 60

Asn Asn Pro His Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Phe
65 70 75 80

Ala Leu Ala Gln Ala Glu His Thr Glu Leu Asp Glu Ser Ile His Leu
85 90 95

Ala Thr Arg Trp Ile Glu Gly Met Gln Ser Gln Asn Gly Gly Tyr Gly
100 105 110

Ala Phe Asp Val Asp Asn Thr Phe Tyr Tyr Leu Asn Glu Ile Pro Phe
115 120 125

Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser Ala
130 135 140

Arg Cys Ala Met Leu Met Ala Arg Val Ala Lys Asp His Glu Glu Tyr
145 150 155 160

Leu Pro Ala Leu Glu Arg Thr Ile Gln Tyr Leu Arg Ser Glu Gln Glu
165 170 175

Ala Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Val Tyr Gly
180 185 190

Thr Trp Ser Val Leu Leu Gly Leu Glu Gln Thr Asn Val Pro Lys Thr
195 200 205

Asp Pro Leu Phe Thr Lys Ala Ala Gln Trp Leu Lys Ser Val Gln Arg
210 215 220

Pro Asp Gly Gly Trp Gly Glu
225 230


<210> 273
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 273
Ser Pro Val Trp Asp Thr Gly Leu Val Ala Leu Ala Leu Pro Glu Val
1 5 10 15

Asp Lys His Asn Ser Gln Asp Ala Leu Gln Pro Asn Leu Lys Gln Ala
20 25 30

Tyr Ser Trp Leu Leu Ser Lys Gln Leu Lys Asp Gln Pro Gly Asp Trp
35 40 45

Arg Ile Ser Lys Pro Thr Leu Thr Gly Gly Gly Trp Ala Phe Gln Phe
50 55 60

Asn Asn Pro His Tyr Pro Asp Val His Asp Thr Ala Val Leu Ala Phe
65 70 75 80

Ala Leu Ala Gln Ala Glu His Thr Glu Leu Asp Glu Ser Ile His Leu
85 90 95

Ala Thr Arg Trp Ile Glu Gly Met Gln Ser Gln Asn Gly Gly Tyr Gly
100 105 110

Ala Phe Asp Val Asp Asn Thr Phe Tyr Tyr Leu Asn Glu Ile Pro Phe
115 120 125

Ala Asp His Gly Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Ser Ala
130 135 140

Arg Cys Ala Met Leu Met Ala Arg Val Ala Lys Gly His Glu Glu Tyr
145 150 155 160

Leu Pro Ala Leu Glu Arg Thr Ile Gln Tyr Leu Arg Ser Glu Gln Glu
165 170 175

Ala Asp Gly Ser Trp Phe Gly Arg Trp Gly Thr Asn Tyr Val Tyr Gly
180 185 190

Thr Trp Ser Val Leu Leu Gly Leu Glu Gln Thr Asn Val Pro Lys Thr
195 200 205

Asp Pro Leu Phe Thr Lys Ala Ala Gln Trp Leu Lys Ser Val Gln Arg
210 215 220

Pro Asp Gly Gly Trp Gly Glu
225 230


<210> 274
<211> 232
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 274
Ser Pro Val Trp Asp Thr Ile Leu Ser Met Gln Ala Leu Leu Asp Thr
1 5 10 15

Lys Glu Val Phe Gln Pro Ser Pro Thr Leu Lys Lys Ala Met Glu Trp
20 25 30

Leu Leu Glu Gln Gln Val Arg Ala Trp Gly Asp Trp Lys Val Tyr Val
35 40 45

Ser Asp Ala Arg Gly Gly Gly Trp Ala Phe Gln Arg Ala Asn Ser Phe
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ile Met Val Met Met Ala Leu Arg Asn
65 70 75 80

Val Ser Pro Arg Gly Glu Ser Lys Val Val Asp Glu Ala Ile Glu Arg
85 90 95

Ala Leu Phe Trp Val Leu Gly Met Gln Cys Glu Asp Gly Gly Trp Ala
100 105 110

Ala Phe Asp Arg Asp Asn Ala Lys Ala Phe Leu Thr Lys Val Pro Phe
115 120 125

Ala Asp His Asn Ala Met Ile Asp Pro Ser Thr Ala Asp Leu Thr Ser
130 135 140

Arg Thr Phe Glu Met Phe Ala Met Ile Ala Pro Glu Val Phe Thr Ile
145 150 155 160

His His Pro Val Val Arg Arg Gly Leu Glu Phe Leu Lys Lys Asp Gln
165 170 175

Cys Lys Asp Gly Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Met Tyr
180 185 190

Gly Thr Trp Gln Val Leu Arg Gly Leu Arg Leu Ile Gly Glu Asp Met
195 200 205

Ser Lys Gly Tyr Val Arg Lys Gly Val Glu Trp Phe Lys Ser Val Gln
210 215 220

Leu Glu Asp Gly Gly Trp Gly Glu
225 230


<210> 275
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 275
Ser Pro Val Trp Asp Thr Leu Leu Ala Leu Leu Ala Leu Gln Asp Cys
1 5 10 15

Asp Arg Glu Leu Thr Ala Glu Met Ser Arg Ala Leu Asp Trp Val Leu
20 25 30

Ala Asn Glu Val Arg Tyr His Gly Asp Trp Thr Lys Lys Val Lys Gly
35 40 45

Val Glu Pro Ser Gly Trp Ala Phe Glu Arg Ala Asn Leu Asn Tyr Pro
50 55 60

Asp Ile Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ala Arg Leu Pro
65 70 75 80

Arg Ala Trp Leu Asp Glu Pro Arg Ile Arg Ala Thr Ile Asp Arg Val
85 90 95

Leu Gly Trp Thr Leu Ala Met Gln Ser Ser Asn Gly Gly Trp Ala Ala
100 105 110

Phe Asp Lys Asp Asn Asp Arg Pro Ile Ile Thr Lys Ile Pro Phe Cys
115 120 125

Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Ala Asp Val Thr Ala His
130 135 140

Val Leu Glu Ala Leu Gly Leu Leu Gly Phe Asp Arg Arg His Pro Ala
145 150 155 160

Val Glu Arg Gly Leu Arg Phe Leu Arg Ser Glu Gln Glu Ala Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Ala Ala
180 185 190

Val Leu Pro Gly Leu Ala Ala Ile Gly Glu Asp Met Thr Gln Asp Tyr
195 200 205

Ile Arg Arg Ala Asn Asp Trp Leu Ile Ala His Gln Asn Pro Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 276
<211> 204
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (201)..(201)
<223> Xaa can be any amino acid

<400> 276
Ser Pro Val Trp Asp Thr Leu Leu Thr Leu Leu Ala Met Glu Asp Cys
1 5 10 15

Asp Arg Gly Leu Thr Pro Ser Met Gln Arg Ala Leu Glu Trp Val Leu
20 25 30

Ala Gln Glu Val Arg Tyr Ala Gly Asp Trp Ser Lys Lys Val Lys Gly
35 40 45

Val Glu Pro Ser Gly Trp Ala Phe Glu Arg Ala Asn Leu Asn Tyr Pro
50 55 60

Asp Ile Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ala Arg Leu Pro
65 70 75 80

Arg Ala Trp Leu Asp Glu Pro Arg Ile Arg Ala Thr Ile Asp Arg Val
85 90 95

Leu Gly Trp Thr Leu Ala Met Gln Ser Ser Asn Gly Gly Trp Ala Ala
100 105 110

Phe Asp Lys Asp Asn Asp Arg Pro Ile Ile Thr Lys Ile Pro Phe Cys
115 120 125

Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Ala Asp Val Thr Ala His
130 135 140

Val Leu Glu Ala Leu Gly Leu Pro Gly Phe Asp Arg Arg His Pro Ala
145 150 155 160

Val Glu Arg Gly Tyr Lys Phe Leu Arg Ser Glu Gln Glu Ala Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Val Asn His Ile Tyr Gly Thr Ala Ala
180 185 190

Val Leu Pro Ala Leu Ala Ser Ile Xaa Glu Asp Met
195 200


<210> 277
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 277
Ser Pro Val Trp Asp Thr Leu Leu Ala Leu Leu Ala Met Gln Asp Cys
1 5 10 15

Glu Arg Glu Leu Thr Pro Gln Met Glu Arg Ala Leu Asp Trp Val Leu
20 25 30

Ala Asn Glu Val Arg Tyr Tyr Gly Asp Trp Ser Lys Lys Val Arg Gly
35 40 45

Val Glu Pro Ser Gly Trp Ala Phe Glu Arg Ala Asn Leu Asn Tyr Pro
50 55 60

Asp Ile Asp Asp Thr Val Val Ala Leu Ile Val Leu Ala Arg Leu Pro
65 70 75 80

Arg Ala Leu Leu Asp Gln Pro Arg Ile Arg Ala Val Ile Asp Arg Ala
85 90 95

Leu Gly Trp Thr Leu Ala Met Gln Ser Ser Asn Gly Gly Trp Ala Ala
100 105 110

Phe Asp Lys Asp Asn Asp His Leu Ile Ile Thr Lys Ile Pro Phe Cys
115 120 125

Gly Phe Gly Glu Ala Leu Asp Pro Pro Ser Ala Asp Val Thr Ala His
130 135 140

Val Leu Glu Ala Leu Gly Leu Leu Gly Phe Asp Arg His His Pro Ala
145 150 155 160

Val Ala Arg Gly Tyr Gln Phe Leu Arg Lys Glu Gln Glu Ala Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Val Asn His Ile Tyr Gly Thr Ala Ala
180 185 190

Val Leu Pro Ala Leu Ala Ala Ile Gly Glu Asp Met Ser Gln Pro Tyr
195 200 205

Ile Arg Ala Ala Ala Glu Trp Ile Ile Ala His Gln Asn Ala Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 278
<211> 204
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (198)..(198)
<223> Xaa can be any amino acid

<400> 278
Ser Pro Val Trp Asp Thr Leu Leu Ser Leu Leu Ala Met Gln Asp Cys
1 5 10 15

Glu Arg Gly Phe Thr Pro Ser Met Glu Arg Ala Leu Asp Trp Val Leu
20 25 30

Ala Asn Glu Val Arg Tyr Tyr Gly Asp Trp Ser Lys Lys Val Arg Gly
35 40 45

Val Glu Pro Ser Gly Trp Ala Phe Glu Arg Ala Asn Leu Asn Tyr Pro
50 55 60

Asp Ile Asp Asp Thr Ala Val Ala Leu Ile Val Leu Ala Arg Leu Pro
65 70 75 80

Arg Ala Gln Leu Asp Gln Pro Arg Ile Arg Glu Val Ile Asp Arg Ala
85 90 95

Leu Gly Trp Thr Leu Ala Met Gln Ser Ser Asn Gly Gly Trp Ala Ala
100 105 110

Phe Asp Lys Asp Asn Asp His Leu Ile Ile Thr Lys Ile Pro Phe Cys
115 120 125

Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Ala Asp Val Ala Ala His
130 135 140

Val Leu Glu Ala Leu Gly Leu Leu Gly Phe Glu Arg Lys His Pro Ala
145 150 155 160

Val Glu Arg Gly Leu Lys Phe Ile Arg Ser Glu Gln Glu Ala Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Val Asn His Ile Tyr Gly Thr Ala Ala
180 185 190

Val Leu Pro Ala Leu Xaa Ala Ile Gly Glu Asp Met
195 200


<210> 279
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (9)..(9)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (31)..(31)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (32)..(32)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (57)..(57)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (102)..(102)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (131)..(131)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (191)..(191)
<223> Xaa can be any amino acid

<400> 279
Ser Pro Val Trp Asp Thr Leu Leu Xaa Leu Leu Ala Met Gln Asp Cys
1 5 10 15

Glu Arg Glu Ser Thr Pro Ser Met Glu Arg Ala Leu Asp Trp Xaa Xaa
20 25 30

Ala Asn Glu Val Arg Tyr Tyr Gly Asp Trp Ser Lys Lys Val Arg Gly
35 40 45

Val Glu Pro Ser Gly Trp Ala Phe Xaa Arg Ala Asn Leu Asn Tyr Pro
50 55 60

Asp Ile Asp Asp Thr Asp Val Ala Leu Ile Val Leu Ala Arg Leu Pro
65 70 75 80

Arg Ala Leu Leu Asp Gln Ser Arg Val His Ala Val Ile Asp Arg Ala
85 90 95

Leu Gly Trp Thr Leu Xaa Met Gln Ser Ser Asn Gly Gly Trp Ala Ala
100 105 110

Phe Asp Lys Asp Asn Asn His Leu Ile Ile Thr Lys Ile Pro Phe Cys
115 120 125

Asp Phe Xaa Glu Ala Leu Asp Pro Pro Ser Ala Asp Val Thr Ala His
130 135 140

Val Leu Glu Ala Leu Gly Leu Leu Gly Phe Asn Arg Asn His Pro Ala
145 150 155 160

Val Glu Arg Gly Tyr Arg Phe Leu Arg Ser Glu Gln Glu Thr Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Val Asn His Val Tyr Gly Thr Xaa Ala
180 185 190

Val Leu Pro Ala Leu Ala Ala Ile Gly Glu Asp Met Thr Gln Pro Tyr
195 200 205

Ile Arg Ser Ala Ala Glu Trp Ile Ile Ala His Gln Asn Ala Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 280
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 280
Ser Pro Val Trp Asp Thr Leu Leu Ser Leu Val Ala Leu Gln Asp Cys
1 5 10 15

Gly Lys Glu Leu Thr Pro Ala Arg Glu Arg Ala Leu Glu Trp Ile Leu
20 25 30

Gly Arg Glu Ile Arg Thr Arg Gly Asp Trp Ala Lys Lys Val Lys Asn
35 40 45

Val Glu Ala Ser Gly Trp Ala Phe Glu Arg Ala Asn Leu His Tyr Pro
50 55 60

Asp Ile Asp Asp Thr Ala Val Ala Leu Ile Met Leu Ala Arg Leu Pro
65 70 75 80

Arg Ala Trp Leu Asp Gln Pro Arg Ile Arg Ala Val Ile Asp Arg Ala
85 90 95

Leu Gly Trp Thr Leu Ala Met Gln Ser Ser Ser Gly Gly Trp Ala Ala
100 105 110

Phe Asp Lys Asp Asn Asp Arg Leu Ile Ile Thr Lys Ile Pro Phe Cys
115 120 125

Asp Phe Gly Glu Ala Leu Asp Pro Pro Ser Ala Asp Val Thr Ala His
130 135 140

Val Leu Glu Ala Leu Gly Ile Leu Gly Phe Asp Arg Gln His Ala Ala
145 150 155 160

Val Arg His Gly Leu Lys Phe Leu Arg Ser Glu Gln Glu Ala Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Val Asn His Val Tyr Gly Thr Gly Ala
180 185 190

Val Leu Pro Ala Leu Ala Ala Ile Gly Glu Asp Met Ala Gln Asp Tyr
195 200 205

Val Arg Arg Ala Ala Asp Trp Leu Val Ala His Gln Asn Ala Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 281
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 281
Ser Pro Val Trp Asp Thr Leu Leu Thr Leu Leu Ala Tyr Gln Asp Cys
1 5 10 15

Glu Leu Glu Met Asn Asp Ser Ala Gly Arg Ala Leu Asp Trp Ile Leu
20 25 30

Ser Gln Glu Asn Ser Tyr Arg Gly Asp Trp Ala His Arg Asn Lys Lys
35 40 45

Leu Glu Pro Ser Gly Trp Ala Phe Glu Arg Ala Asn Leu His Tyr Pro
50 55 60

Asp Ile Asp Asp Thr Ser Val Ala Leu Ile Val Leu Ala Arg Leu Pro
65 70 75 80

Gln Ala Val Arg Ser Arg Pro Asp Ile Lys Ser Ala Ile Asp Arg Ala
85 90 95

Leu Ala Trp Thr Leu Gly Met Gln Cys Arg Asn Gly Gly Trp Ala Ala
100 105 110

Phe Asp Arg Asp Asn Asp Lys Leu Ile Ile Thr Met Ile Pro Phe Cys
115 120 125

Asp Phe Ser Glu Ala Leu Asp Pro Pro Ser Ala Asp Val Thr Ala His
130 135 140

Val Val Glu Ala Met Ala His Leu Gly Phe Asp Arg Ser His Lys Ala
145 150 155 160

Val Glu Lys Ala Tyr Gln Tyr Leu Leu Ala Glu Gln Glu Asp Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Val Asn His Ile Tyr Gly Thr Ala Ala
180 185 190

Val Leu Pro Ala Leu Ala Ala Leu Gly Glu Asp Ala Thr Val Pro His
195 200 205

Val Lys Arg Ala Ala Asp Trp Ile Ser Ala His Gln Asn Thr Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 282
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 282
Ser Pro Met Trp Asp Thr Ser Leu Ala Ala His Ala Leu Met Glu Ala
1 5 10 15

Asp Gly Arg Gly Asp Pro Lys Asp Asn Pro Arg Leu Ile Ser Ala Met
20 25 30

Asp Trp Leu Ala Asp Lys Gln Ile Leu Asp His Val Gly Asp Trp Ala
35 40 45

Val Arg Arg Pro Asp Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Glu
50 55 60

Asn Pro Asp Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Met Ala
65 70 75 80

Met His Arg Ala Asp Pro Glu Arg Tyr Glu Met Ser Ile Asp Arg Ala
85 90 95

Cys Glu Trp Leu Val Gly Met Gln Ser Lys Asn Gly Gly Trp Gly Ala
100 105 110

Phe Glu Pro Glu Asn Glu His Tyr Tyr Leu Asn Ser Ile Pro Phe Ala
115 120 125

Asp His Gly Ala Leu Leu Asp Pro Pro Thr Val Asp Val Thr Ala Arg
130 135 140

Cys Val Gly Ala Leu Ala Gln Val Asp Arg Asp Arg Tyr Ala Ala Glu
145 150 155 160

Ile Ala Asn Gly Ile Arg Ser Ile Arg Arg Glu Gln Glu Asp Asp Gly
165 170 175

Ser Trp Phe Gly Arg Trp Gly Ala Asn Tyr Val Tyr Gly Thr Trp Ser
180 185 190

Ala Leu Val Ala Leu Lys Gly Ala Gly Glu Asp Met Gln Gln Pro Tyr
195 200 205

Ile Arg Arg Ala Val Asp Trp Leu Lys Ala Arg Gln Arg Ser Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 283
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 283
Ser Pro Val Trp Asp Thr Cys Leu Thr Ser Asn Ala Leu Val Glu Ser
1 5 10 15

Gly Gly Asp Thr Ser Ala Pro His Val His Arg Ser Val Gln Trp Leu
20 25 30

Leu Asn Gln Glu Ile Arg Asn His Gly Asp Trp Ser Val Lys Ala Pro
35 40 45

Lys Val Gly Pro Ser Gly Trp Ala Phe Glu Phe Ala Asn Lys Val Tyr
50 55 60

Pro Asp Val Asp Asp Ala Ala Glu Val Ile Ile Ala Leu Ala Asn Tyr
65 70 75 80

Ser Asn Asp Ser Gly Thr Ala Pro Pro Asp Ala Ile Ala Arg Gly Val
85 90 95

Arg Trp Ile Ser Gly Met Gln Ser Ser Asn Gly Gly Trp Gly Ser Phe
100 105 110

Asp Lys Asn Asn Thr Ser Phe Phe Val Thr Arg Leu Pro Phe Phe Asp
115 120 125

Phe Gly Glu Val Ile Asp Pro Pro Ser Val Asp Val Thr Ala His Val
130 135 140

Ile Glu Ala Leu Ala Val Ala Gly Trp Gln Glu Lys Ala Ser Lys Gln
145 150 155 160

Ile Gln Lys Ala Leu Asp Tyr Ile Trp Ser Glu Gln Glu Ala Asp Gly
165 170 175

Pro Trp Phe Gly Arg Trp Gly Ile Asn Tyr Ile Tyr Gly Thr Cys Ala
180 185 190

Val Leu Ser Ala Leu Glu Ala Ile Gly Tyr Asp Met Ala Asp Ala Arg
195 200 205

Val Val Lys Ala Leu Lys Trp Ile Glu Glu Cys Gln Asn Ala Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 284
<211> 228
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 284
Ser Pro Val Trp Asp Thr Val Ala Gln Leu His Ala Leu Ile Ala Ser
1 5 10 15

Gly Leu Ala Arg Arg Asp Glu Ala Leu Arg Arg Ala Ala Ser Trp Leu
20 25 30

Leu Thr Arg Gln Ser Arg Thr His Gly Asp Trp Ser Gly Arg Asn Pro
35 40 45

Ala Glu Pro Gly Gly Phe Tyr Phe Glu Phe Arg Asn Glu Phe Tyr Pro
50 55 60

Asp Val Asp Asp Thr Ala Met Ala Leu Met Val Leu Thr Gln Ala Glu
65 70 75 80

Ala Asn Val Ala Thr Asp Val Gln His Ala Ala Ile Ala Arg Ala Leu
85 90 95

Ala Trp Met Leu Gly Met Gln Asn Arg Asp Gly Gly Trp Ala Ala Phe
100 105 110

Asp Arg Asp Asn Asp Lys His Phe Leu Thr Gln Val Pro Phe Ala Asp
115 120 125

His Asn Ala Met Ile Asp Pro Ser Thr Ala Asp Ile Thr Gly Arg Val
130 135 140

Leu Gly Ala Leu Ser His Val Pro Ser Tyr Gly Pro Asp His Pro Ser
145 150 155 160

Val Arg Arg Ala Ile Ala Phe Leu Gln Arg Asp Gln Glu Pro Asp Gly
165 170 175

Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Gly Gln
180 185 190

Val Leu Arg Gly Leu Arg Ala Ile Gly Phe Asp Met Gln Gln Pro Phe
195 200 205

Val Arg Arg Ala Ala Arg Phe Leu Ser Ala His Gln Asn Asp Asp Gly
210 215 220

Gly Trp Gly Glu
225


<210> 285
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 285
Ser Pro Val Trp Asp Thr Ala Ile Thr Ile Ile Ala Leu Ala Glu Ser
1 5 10 15

Gly Leu Pro Lys Asn His Pro Ala Phe Glu Gln Ala Ala Thr Trp Leu
20 25 30

Glu Lys Lys Glu Ile Arg Phe Lys Gly Asp Trp Ala Val Arg Met Pro
35 40 45

Gly Val Glu Pro Ser Gly Trp Ala Phe Glu His Glu Asn Lys Tyr Tyr
50 55 60

Pro Asp Thr Asp Asp Thr Met Met Val Leu Met Ala Leu Arg His Val
65 70 75 80

Gln Ser Arg Asn Ser Ala Glu Arg Cys Glu Gln Phe Asp Arg Ala Leu
85 90 95

Lys Trp Leu Leu Ala Phe Gln Cys Gln Asp Gly Gly Trp Ala Ala Phe
100 105 110

Asp Lys Asp Val Thr Ala Ser Trp Leu Glu His Val Pro Phe Ala Asp
115 120 125

His Asn Ala Ile Leu Asp Pro Thr Cys Ser Asp Leu Thr Ala Arg Val
130 135 140

Leu Glu Leu Leu Gly Ser Ile Ser Phe Asp Arg Gln Ser Ala Ile Val
145 150 155 160

Arg Arg Ala Val Ala Met Met Arg Arg Thr Gln Glu Thr Asp Gly Ser
165 170 175

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Gln Ala
180 185 190

Leu Arg Gly Leu Ala Ala Ile Gly Glu Asn Met Asp Gln Glu Trp Ile
195 200 205

Arg Arg Gly Arg Asp Trp Leu Glu Ser Cys Gln Asn Asp Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 286
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 286
Ser Pro Val Trp Asp Thr Ala Ile Asn Val Ile Ser Leu Ala Glu Ser
1 5 10 15

Gly Leu Leu Ser Asp His Pro Ala Leu Gln Lys Ala Ala Asp Trp Leu
20 25 30

Val Asn Lys Glu Val Arg Phe Arg Gly Asp Trp Ser Val Asn Asn Ser
35 40 45

Tyr Pro Gln Val Ser Gly Trp Ala Phe Glu Tyr Asn Asn Val Tyr Tyr
50 55 60

Pro Asp Thr Asp Asp Thr Ala Met Val Leu Met Ala Leu Arg Leu Ile
65 70 75 80

Arg Pro Lys Asp Pro Gln Ala Leu Asn Glu Leu Phe Arg Arg Ala Leu
85 90 95

Asp Trp Gln Leu Ser Phe Gln Cys Arg Asp Gly Gly Trp Ala Ala Phe
100 105 110

Asp Lys Asn Val Thr Thr Pro Trp Leu Glu Asp Met Pro Phe Ala Asp
115 120 125

His Asn Ala Ile Leu Asp Pro Thr Cys Ser Asp Leu Thr Ala Arg Thr
130 135 140

Leu Glu Leu Leu Gly Tyr Thr Gly Phe Asp Pro Lys Ala Gln Ser Val
145 150 155 160

Arg Asp Ala Leu Gln Tyr Leu Ile Asp Thr Gln Asp Glu Asp Gly Ser
165 170 175

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Gln Val
180 185 190

Leu Arg Gly Leu Arg Ala Met Gly Gln Asp Met Thr Gln Asp Trp Ile
195 200 205

Leu Arg Gly Arg Asp Trp Leu Glu Ser Cys Gln Asn Ser Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 287
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 287
Ser Pro Val Trp Asp Thr Ala Ile Thr Ser Val Ala Leu Thr Ser Ser
1 5 10 15

Gly Val Lys Pro Asp His Pro Gln Ile Gln Lys Ala Ala Asp Trp Leu
20 25 30

Leu Asp Arg Glu Val Val Met Arg Gly Asp Trp Lys Val Lys Asn Pro
35 40 45

Tyr Pro His Ala Ser Gly Trp Ala Phe Glu Phe Asn Asn Asp Phe Tyr
50 55 60

Pro Asp Ala Asp Asp Thr Phe Lys Val Leu Leu Ala Leu Met Lys Met
65 70 75 80

Lys Ser Ser Asp Pro Glu Arg Gln Arg Lys Ile Met Asp Arg Ala Leu
85 90 95

Asp Trp Ala Arg Ser Phe Gln Cys Lys Asp Gly Gly Phe Ala Ala Phe
100 105 110

Asp Lys Asp Val Thr Lys Lys Trp Leu Glu His Val Pro Phe Ala Asp
115 120 125

His Asn Ala Ile Leu Asp Pro Ser Cys Ser Asp Ile Thr Ala Arg Gly
130 135 140

Leu Glu Cys Met Gly Lys Leu Gly Trp Pro Arg Thr Asp Arg Val Ile
145 150 155 160

Arg Arg Ala Ile Arg Tyr Leu Lys Lys Thr Gln Glu Glu Asp Gly Ser
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Gln Ser
180 185 190

Leu Arg Gly Leu Glu Ala Ile Gly Glu Asp Met Asn Gln Asp Trp Val
195 200 205

Val Arg Ala Arg Asn Trp Leu Glu Ser Cys Gln Asn Pro Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 288
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 288
Ser Pro Val Trp Asp Thr Ala Ile Thr Ala Val Ser Leu Ala Glu Ser
1 5 10 15

Gly Leu Glu Pro Asp His Pro Ala Leu Gln Lys Ser Ala Glu Trp Leu
20 25 30

Leu Asp Lys Glu Val Arg Ile Gln Gly Asp Trp Ala Ile Lys Asn Arg
35 40 45

His Gly Glu Ala Ser Gly Trp Ala Phe Glu Phe Asn Asn Glu Phe Tyr
50 55 60

Pro Asp Val Asp Asp Thr Leu Lys Val Leu Leu Ala Leu Arg Leu Ile
65 70 75 80

Lys Thr Arg Asp Glu Glu Thr Lys Arg Glu Ala Met Glu Arg Ala Leu
85 90 95

Gly Trp Val Met Ser Phe Gln Cys Ser Asp Gly Gly Trp Ala Ala Phe
100 105 110

Asp Lys Asp Val Thr Gln Arg Trp Leu Glu Asp Val Pro Phe Ala Asp
115 120 125

His Asn Ala Ile Leu Asp Pro Thr Cys Ser Asp Ile Thr Ala Arg Cys
130 135 140

Leu Glu Leu Leu Gly Lys Met Gly Cys Thr Ser Asp His Pro Ala Val
145 150 155 160

Arg Arg Ala Leu Arg Met Val Arg Glu Thr Gln Glu Pro Asp Gly Thr
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Gln Ile
180 185 190

Leu Arg Gly Leu Ser Ala Leu Lys Ile Asp Met Asn Gln Asp Trp Ile
195 200 205

Val Arg Ala Lys Glu Trp Leu Glu Ser Cys Gln Asn Pro Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 289
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 289
Ser Pro Ile Trp Asp Thr Ala Ile Val Thr Met Ala Ile Ala Glu Ser
1 5 10 15

Gly Gln Asp Pro Asn Asp Pro Arg Leu Gln Lys Ala Ala Asp Trp Leu
20 25 30

Leu Glu Arg Glu Ile Gly Phe Arg Gly Asp Trp Arg Glu Asn Cys Asp
35 40 45

Phe Pro Glu Ala Thr Gly Trp Ala Phe Glu Phe Asn Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Thr Phe Gln Val Ile Leu Gly Leu Lys Pro Leu
65 70 75 80

Ser Ala Ser Asp Ser Arg Arg Gln Glu Gln Thr Leu Asp Arg Ala Ile
85 90 95

Arg Trp Cys Arg Ala Met Gln Cys Arg Glu Gly Gly Phe Ala Ala Phe
100 105 110

Asp Lys Asp Ile Asn Asp Ala Trp Leu Asn Glu Val Pro Phe Ala Asp
115 120 125

His Asn Ala Ile Leu Asp Pro Pro Cys Ser Asp Ile Thr Gly Arg Ala
130 135 140

Leu Glu Thr Leu Ser Leu Met Gly Phe Asp Arg Glu Asp Pro Val Val
145 150 155 160

Arg Arg Ala Arg Gln Tyr Leu Met Glu Thr Gln Leu Glu Asp Gly Ser
165 170 175

Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Gly His Ala
180 185 190

Leu Arg Gly Leu His Ala Ile Gly Glu Asp Ile Asn Gly Ser Ala Met
195 200 205

Gln Arg Ala Arg Asn Trp Leu Glu Asn Cys Gln Asn Asp Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 290
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 290
Ser Pro Ile Trp Asp Thr Ala Lys Ala Val Asn Ala Leu His Glu Ser
1 5 10 15

Gly Leu Pro Ser Asp His Pro Gln Leu Lys Ala Ala Ala Arg Trp Leu
20 25 30

Val Glu Lys Glu Val Arg Lys Pro Gly Asp Trp Lys Met Arg Val Pro
35 40 45

His Val Asp Val Gly Gly Trp Pro Phe Gln Phe Arg Asn Glu Phe Tyr
50 55 60

Pro Asp Val Asp Asp Thr Ala Ala Val Val Met Ala Leu Gly Arg Val
65 70 75 80

Asp Glu Arg Asp Val Pro Gly Ile Lys Asp Ser Ile Thr Arg Gly Ile
85 90 95

Asn Trp Val Thr Gln Met Gln Cys Ser Cys Gly Gly Trp Ala Ala Phe
100 105 110

Asp Val Asp Val Lys Arg Glu Phe Leu Thr Lys Val Pro Tyr Ala Asp
115 120 125

His Asn Ala Met Leu Asp Pro Pro Cys Pro Asp Ile Thr Gly Arg Cys
130 135 140

Leu Glu Met Tyr Gly Arg Phe Pro Gly Val Arg Lys Asp Ala Asp Val
145 150 155 160

Gln Arg Val Ile Glu Lys Gly Ile Glu Tyr Leu Lys Lys Thr Gln Glu
165 170 175

Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Trp Gln Ser Leu Lys Gly Leu Ala Ala Val Gly Glu Asp Pro Ser
195 200 205

Gln Pro Tyr Ile Gln Lys Ala Ala His Phe Leu Lys Thr His Gln Asn
210 215 220

Ser Asp Gly Gly Trp Gly Glu
225 230


<210> 291
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 291
Ser Pro Met Trp Asp Thr Ala Lys Ala Val Asn Ala Leu His Glu Ser
1 5 10 15

Gly Leu Pro Ser Asp His Pro Gln Leu Lys Ala Ala Ala Arg Trp Leu
20 25 30

Val Glu Lys Glu Val Gln Lys Pro Gly Asp Trp Lys Met Arg Val Pro
35 40 45

Tyr Val Asp Val Gly Gly Trp Pro Phe Gln Phe Arg Asn Glu Phe Tyr
50 55 60

Pro Asp Val Asp Asp Thr Ala Ala Val Val Met Ala Leu Gly Arg Val
65 70 75 80

Asp Glu Arg Asp Val Pro Gly Ile Lys Asp Ser Ile Thr Arg Gly Ile
85 90 95

Asn Trp Val Thr Gln Met Gln Cys Ser Cys Gly Gly Trp Ala Ala Phe
100 105 110

Asp Val Asp Val Lys Arg Glu Phe Leu Thr Lys Val Pro Tyr Ala Asp
115 120 125

His Asn Ala Met Leu Asp Pro Pro Cys Pro Asp Ile Thr Gly Arg Cys
130 135 140

Leu Glu Met Tyr Gly Arg Phe Pro Glu Val Arg Lys Asp Val Asp Val
145 150 155 160

Gln Arg Val Ile Glu Lys Gly Ile Glu Tyr Leu Lys Lys Thr Gln Glu
165 170 175

Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Trp Gln Ser Leu Lys Gly Leu Ala Ala Val Gly Glu Asp Pro Ser
195 200 205

Gln Pro Tyr Ile Gln Lys Ala Ala His Phe Leu Lys Thr His Gln Asn
210 215 220

Ser Asp Gly Gly Trp Gly Glu
225 230


<210> 292
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 292
Ser Pro Val Trp Asp Thr Ala Lys Ala Val Asn Ala Leu His Glu Ser
1 5 10 15

Gly Leu Pro Ser Asp His Pro Gln Leu Lys Ala Ala Ala Arg Trp Leu
20 25 30

Val Glu Lys Glu Val Arg Lys Pro Gly Asp Trp Lys Met Arg Val Pro
35 40 45

His Val Asp Val Gly Gly Trp Pro Phe Gln Phe Arg Asn Glu Phe Tyr
50 55 60

Pro Asp Val Asp Asp Thr Ala Ala Val Val Met Ala Leu Gly Arg Val
65 70 75 80

Asp Glu Arg Asp Val Pro Gly Ile Lys Asp Ser Ile Thr Arg Gly Ile
85 90 95

Asn Trp Val Thr Gln Met Gln Cys Ser Cys Gly Gly Trp Ala Ala Phe
100 105 110

Asp Val Asp Val Lys Arg Glu Phe Leu Thr Lys Val Pro Tyr Ala Asp
115 120 125

His Asn Ala Met Leu Asp Pro Pro Cys Pro Asp Ile Thr Gly Arg Cys
130 135 140

Leu Glu Met Tyr Gly Arg Phe Pro Glu Val Arg Lys Asp Ala Asn Val
145 150 155 160

Gln Asn Val Ile Ala Lys Gly Ile Glu Tyr Leu Lys Lys Thr Gln Glu
165 170 175

Pro Asp Gly Ser Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Trp Gln Ser Leu Lys Gly Leu Ala Ala Val Gly Glu Asp Pro Ser
195 200 205

Gln Pro Tyr Ile Gln Lys Ala Ala His Phe Leu Lys Thr His Gln Asn
210 215 220

Ser Asp Gly Gly Trp Gly Glu
225 230


<210> 293
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 293
Ser Pro Val Trp Asp Thr Cys Leu Ser Leu Ala Ala Leu Thr Glu Ala
1 5 10 15

Gly Ala Gln Asn Asp His Pro Ala Val Lys Gln Ala Val Glu Trp Leu
20 25 30

Leu Asp His Gln Ile Phe Val Glu Gly Asp Trp Cys Ala Gln Ala Ser
35 40 45

Gly Leu Glu Pro Gly Gly Trp Ala Phe Gln Tyr Glu Asn Asp Lys Tyr
50 55 60

Pro Asp Val Asp Asp Thr Gly Met Val Leu Met Ser Leu Leu Arg Ala
65 70 75 80

Gly Val His Asp Lys Glu His Lys Arg Lys Arg Val Asn Gln Ala Leu
85 90 95

Asn Trp Val Leu Gly Met Gln Asn Pro Asp Gly Ser Trp Gly Ala Phe
100 105 110

Asp Ile Glu Asn Asn Tyr Glu Tyr Leu Asn Lys Ile Pro Phe Ala Asp
115 120 125

His Gly Ala Leu Val Asp Pro Gly Thr Ala Asp Leu Thr Ala Arg Cys
130 135 140

Val Glu Leu Leu Ala Met Leu Gly Tyr Asp Ala Thr Phe Pro Pro Val
145 150 155 160

Lys Arg Ala Leu Glu Phe Leu Glu His Asp Gln Glu Glu Asp Gly Ser
165 170 175

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Cys Ala Leu Gly Ala Ile Gly Glu Asp Val Ala Lys Pro Tyr Val
195 200 205

Arg Lys Ser Val Gln Trp Leu Gln Asp Thr Gln Asn Glu Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 294
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 294
Ser Pro Val Trp Asp Thr Cys Leu Ser Leu Ala Ala Leu Thr Glu Ala
1 5 10 15

Gly Ala Gln Asn Asp His Pro Ala Val Lys Gln Ala Val Glu Trp Leu
20 25 30

Leu Asp His Gln Ile Phe Val Glu Gly Asp Trp Cys Asp Gln Ala Pro
35 40 45

Gly Leu Glu Pro Gly Gly Trp Ala Phe Gln Tyr Glu Asn Asn Lys Tyr
50 55 60

Pro Asp Val Asp Asp Thr Gly Met Val Leu Met Ser Leu Leu Arg Ala
65 70 75 80

Gly Val His Asp Lys Glu His Lys Arg Lys Arg Val Asn Gln Ala Leu
85 90 95

Asn Trp Val Leu Gly Met Gln Asn Pro Asp Gly Ser Trp Gly Ala Phe
100 105 110

Asp Ile Glu Asn Asn Tyr Glu Tyr Leu Asn Arg Ile Pro Phe Ala Asp
115 120 125

His Gly Ala Leu Val Asp Pro Gly Thr Ala Asp Leu Thr Ala Arg Cys
130 135 140

Val Glu Leu Leu Ala Met Leu Gly Tyr Asp Ala Thr Phe Pro Pro Val
145 150 155 160

Lys Arg Ala Leu Glu Phe Leu Glu Gln Asp Gln Glu Glu Asp Gly Ser
165 170 175

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Cys Ala Leu Gly Ala Thr Gly Glu Asp Val Ala Lys Pro Tyr Val
195 200 205

Arg Lys Ser Val Gln Trp Leu Gln Asp Thr Gln Asn Glu Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 295
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 295
Ser Pro Val Trp Asp Thr Cys Leu Ser Leu Thr Ala Met Thr Glu Ser
1 5 10 15

Gly Ala His Pro Glu His Pro Ala Val Lys Gln Ala Val Glu Trp Leu
20 25 30

Leu Asp Gln Gln Ile Phe Val Lys Gly Asp Trp Ala Asp Gln Ala Lys
35 40 45

Asn Leu Glu Pro Gly Gly Trp Ala Phe Gln Phe Glu Asn Asp Arg Cys
50 55 60

Pro Asp Val Asp Asp Thr Gly Met Val Leu Met Ala Leu Leu Arg Ala
65 70 75 80

Gly Val Gln Asp Lys Glu His Lys Ile Lys Arg Ile Asn Gln Ala Val
85 90 95

Asn Trp Val Leu Gly Met Gln Asn Pro Asp Gly Ser Trp Gly Ala Phe
100 105 110

Asp Ile Gly Asn Asp His Glu Tyr Leu Asn Asn Ile Pro Phe Ala Asp
115 120 125

His Gly Ala Leu Val Asp Pro Gly Thr Ala Asp Leu Thr Ala Arg Cys
130 135 140

Val Glu Leu Leu Ala Met Leu Gly Tyr Gly Pro Asp Phe Pro Pro Ile
145 150 155 160

Gln Arg Ala Val Ala Phe Leu Glu Arg Asp Gln Glu Glu Phe Gly Ala
165 170 175

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Ser Ala Ile Gly Ile Leu Gly Glu Asp Tyr Ala Lys Pro Tyr Val
195 200 205

Arg Lys Ala Val Glu Trp Leu Lys Glu Ile Gln Asn Asp Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 296
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 296
Ser Pro Val Trp Asp Thr Cys Leu Ser Leu Asn Ala Leu Thr Glu Ala
1 5 10 15

Asp Met Pro Ala Asn Asp Pro Arg Val Arg Ala Ala Val Gln Trp Leu
20 25 30

Phe Asp Arg Gln Ile Phe Val Arg Gly Asp Trp Ser Glu Asn Ala Pro
35 40 45

Glu Leu Glu Pro Gly Gly Trp Ala Phe Gln Tyr Glu Asn Asp Lys Tyr
50 55 60

Pro Asp Val Asp Asp Thr Gly Met Val Leu Met Ser Leu Leu Arg Ala
65 70 75 80

Asn Ala His Glu His Asp Ala Gln Arg Lys Arg Met Asn Gln Ala Leu
85 90 95

Asn Trp Val Leu Gly Met Gln Asn Ser Asp Gly Ser Trp Gly Ala Phe
100 105 110

Asp Ile Asp Asn His Tyr Thr Tyr Leu Asn Asn Ile Pro Phe Ala Asp
115 120 125

His Gly Ala Leu Val Asp Pro Gly Thr Ala Asp Leu Thr Gly Arg Cys
130 135 140

Ile Glu Leu Phe Gly Met Leu Gly Tyr Asp Lys Asn Phe Thr Pro Ala
145 150 155 160

Arg Arg Gly Ile Glu Phe Leu Lys Arg Asp Gln His Pro Cys Gly Gly
165 170 175

Trp Tyr Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Trp Ser Val
180 185 190

Leu Thr Ala Leu Gly Ala Ile Gly Glu Ala Arg Asp Ala Pro Tyr Leu
195 200 205

Arg Arg Ala Val Glu Trp Leu Tyr Ser Val Gln Asn Asp Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 297
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 297
Ser Pro Val Trp Asp Thr Ala Leu Val Leu Gln Ala Met Gln Glu Ala
1 5 10 15

Ser Ile Pro Leu Asp His Pro Ala Leu Val Lys Ala Ala Gln Trp Leu
20 25 30

Leu Asp Arg Glu Val Arg Ile Lys Gly Asp Trp Lys Ile Lys Ser Pro
35 40 45

Gly Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Gln Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Ala Ala Val Leu Ile Ala Ile Lys Asp Ile
65 70 75 80

Gln Val Lys Asn Asn Lys Ala Lys Gln Gly Ala Val Arg Arg Gly Ile
85 90 95

Asp Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Trp Gly Ala Phe
100 105 110

Asp Lys Asp Asn Thr Lys His Leu Leu Asn Lys Ile Pro Phe Ala Asp
115 120 125

Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr Gly Arg Met
130 135 140

Leu Glu Leu Met Gly Asn Phe Gly Tyr Asp Lys His His Pro Gln Ala
145 150 155 160

Val His Ala Leu Glu Phe Leu Lys Lys Glu Gln Glu Pro Glu Gly Pro
165 170 175

Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Tyr Val
180 185 190

Leu Ile Gly Leu Glu Ala Ile Gly Glu Asp Met Asn Gln Pro Tyr Ile
195 200 205

Lys Lys Ala Ala Asn Trp Ile Lys Ser Arg Gln Asn Ile Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 298
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (78)..(78)
<223> Xaa can be any amino acid

<400> 298
Ser Pro Val Trp Asp Thr Thr Leu Val Leu Val Ala Met Gln Glu Ala
1 5 10 15

Gly Val Pro Val Asp His Pro Ala Leu Val Lys Ser Ala Gln Trp Leu
20 25 30

Leu Asp Leu Glu Val Arg Arg Lys Gly Asp Trp Gln Val Lys Ser Pro
35 40 45

Asp Val Glu Pro Gly Gly Trp Ala Phe Glu Phe Met Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Gly Phe Val Met Leu Ala Ile Xaa Asn Ile
65 70 75 80

Arg Val Arg Asp Lys Lys His Gln Glu Gln Ala Ile Lys Arg Gly Ile
85 90 95

Ala Trp Cys Leu Glu Met Gln Ser Glu Asn Gly Gly Trp Gly Ala Phe
100 105 110

Asp Lys Asp Asn Thr Lys Tyr Leu Leu Asn Lys Ile Pro Phe Ala Asp
115 120 125

Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr Gly Arg Met
130 135 140

Leu Glu Leu Met Gly Asn Phe Asp Tyr Ser Ala Ser Tyr Pro Ala Ala
145 150 155 160

Val Arg Ala Leu Glu Phe Leu Lys Lys Glu Gln Glu Pro Glu Gly Pro
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Cys Gly Leu Glu Ala Ile Gly Glu Asp Met Ser Gln Pro Tyr Ile
195 200 205

Arg Lys Ala Val Asn Trp Leu Lys Ser Lys Gln Asn Leu Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 299
<211> 294
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 299
Ser Pro Val Trp Asp Thr Ala Leu Val Leu Val Ala Met Gln Glu Ala
1 5 10 15

Gly Val Pro Val Asp His Pro Ala Leu Ile Lys Ser Ala Gln Trp Leu
20 25 30

Leu Asp Leu Glu Val Arg Arg Lys Gly Asp Trp His Val Lys Ser Pro
35 40 45

Asp Leu Glu Pro Gly Gly Trp Ala Phe Glu Ser Leu Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Gly Phe Val Met Leu Phe Ile Lys Asp Ile
65 70 75 80

Lys Val Arg Asp Lys Lys Leu Lys Asp Gln Ala Ile Lys Cys Gly Ile
85 90 95

Ala Trp Cys Leu Gly Met Gln Ser Glu Asn Gly Gly Trp Gly Ala Phe
100 105 110

Asp Lys Asp Asn Thr Lys His Leu Leu Asn Lys Ile Pro Phe Ala Asp
115 120 125

Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr Gly Arg Met
130 135 140

Leu Glu Leu Met Gly Asn Phe Asn Tyr Pro Lys Ser His Gln Ala Ala
145 150 155 160

Val Lys Ala Leu Asp Phe Leu Lys Val Glu Gln Glu Pro Glu Gly Pro
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Cys Gly Leu Glu Ala Ile Gly Glu Asp Met Ser Gln Pro Tyr Ile
195 200 205

Lys Lys Ala Val Asn Trp Leu Lys Ser Lys Gln Asn Leu Asp Gly Gly
210 215 220

Trp Gly Glu Val Cys Asp Ser Tyr Ala Asp Arg Ser Leu Met Gly Cys
225 230 235 240

Gly Pro Ser Thr Ala Ser Gln Thr Ser Trp Ala Leu Leu Ser Leu Phe
245 250 255

Ala Ala Gly Glu Val Ser Ser Lys Ala Ala Leu Arg Gly Val Glu Tyr
260 265 270

Leu Leu Ser Thr Gln Lys Leu Asp Gly Thr Trp Asp Glu Asp Ala Phe
275 280 285

Thr Gly Thr Gly Phe Pro
290


<210> 300
<211> 294
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (15)..(15)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (21)..(21)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (38)..(38)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (39)..(39)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (58)..(58)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (79)..(79)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (128)..(128)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (139)..(139)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (168)..(168)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (171)..(171)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (174)..(174)
<223> Xaa can be any amino acid

<400> 300
Ser Pro Val Trp Asp Thr Ala Leu Val Leu Val Ala Met Gln Xaa Ala
1 5 10 15

Gly Val Pro Val Xaa His Pro Ala Leu Val Lys Ser Ala Gln Trp Leu
20 25 30

Leu Asp Leu Glu Val Xaa Xaa Lys Gly Asp Trp Gln Val Lys Ser Pro
35 40 45

Glu Leu Glu Pro Gly Gly Trp Ala Phe Xaa Phe Leu Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Gly Phe Val Met Leu Ser Ile Lys Xaa Ile
65 70 75 80

Lys Val Arg Asp Lys Lys His Lys Glu Gln Ala Ile Lys Arg Gly Ile
85 90 95

Ser Trp Cys Leu Gly Met Gln Ser Asp Asn Gly Gly Trp Ala Ala Phe
100 105 110

Asp Lys Asn Asn Thr Lys Tyr Leu Leu Asn Lys Ile Pro Phe Ala Xaa
115 120 125

Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Xaa Leu Thr Gly Arg Met
130 135 140

Leu Glu Leu Met Gly Asn Phe Asn Tyr Pro Lys Thr His Lys Ala Ala
145 150 155 160

Val Gln Ala Leu Glu Phe Leu Xaa Met Glu Xaa Glu Pro Xaa Gly Pro
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Cys Gly Leu Glu Ala Ile Gly Glu Asp Met Ala Gln Pro Tyr Ile
195 200 205

Lys Lys Ser Ile Asn Trp Leu Lys Ser Lys Gln Asn Met Asp Gly Gly
210 215 220

Trp Gly Glu Val Cys Glu Ser Tyr Gly Asp Arg Ser Leu Met Gly Cys
225 230 235 240

Gly Pro Ser Thr Ala Ser Gln Thr Ser Trp Ala Leu Leu Ser Leu Phe
245 250 255

Ala Ala Gly Glu Val His Ser Lys Ala Ala Thr Arg Gly Ile Glu Tyr
260 265 270

Leu Leu Ala Thr Gln Lys Leu Asp Gly Thr Trp Asp Glu Asp Ala Tyr
275 280 285

Thr Gly Thr Gly Phe Pro
290


<210> 301
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 301
Ser Pro Val Trp Asp Thr Ala Leu Ala Leu Val Ala Met Gln Glu Ala
1 5 10 15

Gly Val Pro Lys Asp His Pro Ala Leu Val Lys Ala Ala Gln Trp Leu
20 25 30

Leu Asp Leu Glu Val Arg Arg Lys Gly Asp Trp Gln Ile Lys Ser Pro
35 40 45

Glu Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Gly Phe Val Ile Met Ala Ile Arg Asp Ile
65 70 75 80

Lys Ala Pro Asp Lys Lys His Lys Glu Gln Ala Ile Lys Arg Gly Ile
85 90 95

Ala Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Trp Gly Ala Phe
100 105 110

Asp Lys Asp Asn Thr Lys His Leu Leu Asn Lys Ile Pro Phe Ala Asp
115 120 125

Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr Gly Arg Met
130 135 140

Leu Glu Leu Met Gly Ser Phe Asp Tyr Pro Met Asp His Pro Ala Ala
145 150 155 160

Ala Arg Ala Leu Glu Phe Leu Lys Lys Glu Gln Glu Pro Glu Gly Pro
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Cys Gly Leu Glu Ser Ile Gly Glu Asp Met Ser Gln Pro Tyr Ile
195 200 205

Lys Lys Ala Val Asn Trp Leu Lys Ser Lys Gln Asn Met Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 302
<211> 294
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 302
Ser Pro Val Trp Asp Thr Ser Leu Val Leu Val Ala Met Gln Glu Ala
1 5 10 15

Gly Val Pro Val Asp His Pro Ala Leu Val Lys Ala Ala Gln Trp Leu
20 25 30

Leu Asp Arg Glu Val Arg Leu Lys Gly Asp Trp Arg Val Lys Ser Pro
35 40 45

Asp Leu Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Gly Phe Val Met Leu Ala Leu Lys Asp Ile
65 70 75 80

Lys Val Arg Asp Lys Lys Gln Lys Ser Gln Ala Ile Lys Arg Gly Ile
85 90 95

Ala Trp Cys Leu Gly Met Gln Ser Ala Asn Gly Gly Trp Gly Ala Phe
100 105 110

Asp Lys Asp Asn Thr Lys Tyr Leu Leu Asn Lys Ile Pro Phe Ala Asp
115 120 125

Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr Gly Arg Met
130 135 140

Leu Glu Leu Met Gly Thr Phe Asn Tyr Pro Lys Ser His Val Ala Val
145 150 155 160

Val Arg Ala Leu Gly Phe Leu Lys Ser Val Gln Glu Pro Glu Gly Pro
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Leu Gly Gly Leu Asp Ala Ile Gly Glu Asp Met Ser Gln Pro Tyr Ile
195 200 205

Arg Lys Ala Val Asn Trp Leu Lys Ser Lys Gln Asn Leu Asp Gly Gly
210 215 220

Trp Gly Glu Val Cys Glu Thr Tyr Glu Asp Arg Ser Leu Met Gly Cys
225 230 235 240

Gly Pro Ser Thr Pro Ser Gln Thr Ser Trp Ala Leu Leu Ser Leu Phe
245 250 255

Ser Ala Gly Glu Ile Asn Ala Lys Ala Val Leu Arg Gly Ile Lys Tyr
260 265 270

Leu Val Glu Thr Gln Asn Gln Asp Gly Ser Trp Asp Glu Asp Ala Tyr
275 280 285

Thr Gly Thr Gly Phe Pro
290


<210> 303
<211> 227
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 303
Ser Pro Val Trp Asp Thr Ala Leu Val Leu Val Ala Met Gln Glu Ala
1 5 10 15

Gly Val Pro Leu Asp His Pro Ala Leu Val Lys Ala Ala Gln Trp Leu
20 25 30

Leu Asp Arg Glu Val Arg Ile Lys Gly Asp Trp Arg Ile Lys Ser Pro
35 40 45

Asp Ile Glu Pro Gly Gly Trp Ala Phe Glu Phe Leu Asn Asp Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Gly Phe Val Met Leu Ala Ile Lys Asp Val
65 70 75 80

Lys Val Arg Asp Lys Lys Lys Lys Glu Gln Ala Ile Lys Arg Gly Ile
85 90 95

Asn Trp Cys Leu Gly Met Gln Ser Ala Asn Gly Gly Trp Gly Ala Phe
100 105 110

Asp Lys Asp Asn Thr Lys Tyr Leu Leu Asn Lys Ile Pro Phe Ala Asp
115 120 125

Leu Glu Ala Leu Ile Asp Pro Pro Thr Ala Asp Leu Thr Gly Arg Met
130 135 140

Leu Glu Leu Leu Gly Thr Phe Asn Phe Pro Lys Asp His His Ala Ile
145 150 155 160

Glu Arg Ala Leu Glu Phe Ile Gln Leu Glu Gln Glu Pro Glu Gly Pro
165 170 175

Trp Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val
180 185 190

Ile Ser Gly Leu Glu Ala Ile Gly Glu Asp Met Ser Gln Pro Tyr Ile
195 200 205

Arg Lys Thr Val Asn Trp Leu Lys Ser Lys Gln Asn Met Asp Gly Gly
210 215 220

Trp Gly Glu
225


<210> 304
<211> 294
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (22)..(22)
<223> Xaa can be any amino acid

<400> 304
Ser Pro Val Trp Asp Thr Pro Trp Met Val Met Ala Leu Leu Glu Ala
1 5 10 15

Gly Val Pro Thr Asp Xaa Pro Gly Leu Leu Arg Ala Gly Arg Trp Leu
20 25 30

Ile Ser Lys Gln Ile Thr Gly Val His Gly Asp Trp Ala Val Lys Asn
35 40 45

Arg His Ala Leu Pro Gly Gly Trp Ser Phe Glu Phe Glu Asn Asp Tyr
50 55 60

Phe Pro Asp Val Asp Asp Thr Ile Glu Val Leu His Val Ile His Arg
65 70 75 80

Leu Ala Ile Pro Trp Glu Glu Lys Ser Glu Cys Cys Arg Leu Gly Leu
85 90 95

Asp Trp Leu Leu Ser Met Gln Asn Asp Asp Gly Gly Trp Gly Ala Phe
100 105 110

Asp Arg Asn Gln Thr Leu Val Met Val Asn Arg Ile Pro Phe Ser Asp
115 120 125

His Ala Ala Cys Leu Asp Pro Ser Ser Pro Asp Ile Val Gly Arg Val
130 135 140

Leu Glu Phe Leu Ala Ser Arg Ser Phe Ser Arg Glu His Pro Ala Val
145 150 155 160

Lys Arg Ala Leu Asp Tyr Ile Trp Arg Glu Gln Ser Pro Phe Gly Gly
165 170 175

Trp Trp Ala Arg Trp Gly Ile Asp Tyr Leu Tyr Gly Thr Trp Cys Val
180 185 190

Leu Thr Gly Leu Arg Ala Ile Gly Trp Asp Met Glu Asp Pro Arg Val
195 200 205

Arg Lys Ala Val Ala Trp Leu Glu Ser Val Ala Arg Pro Asp Gly Gly
210 215 220

Tyr Gly Glu Ser Pro Glu Ser Tyr Arg Asp His Ser Tyr Val Glu Trp
225 230 235 240

Lys Arg Ser Val Pro Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Val
245 250 255

Ala Gly Gly Val Gly His Gly Lys Ala Ala Arg Gly Ala Ala Asp Tyr
260 265 270

Leu Leu Thr Ser Arg Asn Ala Gln Gly Gly Trp Asp Glu Met Asp Tyr
275 280 285

Thr Gly Thr Gly Phe Pro
290


<210> 305
<211> 294
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (24)..(24)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (36)..(36)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (99)..(99)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (103)..(103)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (117)..(117)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (151)..(151)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (173)..(173)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (202)..(202)
<223> Xaa can be any amino acid

<400> 305
Ser Pro Val Trp Asp Thr Pro Trp Met Val Met Ala Leu Leu Glu Ala
1 5 10 15

Gly Cys Pro Ala Asn Asp Pro Xaa Leu Ile Arg Ala Gly Arg Trp Leu
20 25 30

Lys Ala Lys Xaa Ile Thr Glu Val Arg Gly Asp Trp Ala Val Lys Asn
35 40 45

Arg Lys Ala Leu Pro Gly Gly Trp Ser Phe Glu Phe Glu Asn Asp Tyr
50 55 60

Phe Pro Asp Val Asp Asp Thr Ile Glu Val Leu Ser Val Ile His Arg
65 70 75 80

Leu Ser Ile Pro Trp Asn Glu Lys Ala Lys Ser Cys Arg Leu Gly Leu
85 90 95

Glu Trp Xaa Leu Ser Met Xaa Asn Arg Asp Gly Gly Trp Gly Ala Phe
100 105 110

Asp Arg Glu Gln Xaa Phe Lys Val Val Asn Arg Ile Pro Phe Ser Asp
115 120 125

His Ala Ala Cys Leu Asp Pro Ser Ser Pro Asp Ile Thr Gly Arg Met
130 135 140

Val Glu Phe Leu Ala Ser Xaa Asn Phe Ser Lys Gly His Val Ala Val
145 150 155 160

Arg Arg Ala Leu Asp Tyr Ile Trp Lys Gln Gln Ala Xaa Phe Gly Gly
165 170 175

Trp Trp Ala Arg Trp Gly Ile Asp Tyr Leu Tyr Gly Thr Trp Cys Val
180 185 190

Leu Thr Gly Leu Ala Ser Leu Gly Phe Xaa Met Asp Asp Pro Arg Ala
195 200 205

Arg Lys Ala Ala Asp Trp Leu Glu Ser Ile Gln His Ala Asp Gly Gly
210 215 220

Phe Gly Glu Ser Pro Glu Ser Tyr Arg Glu Asp Ser Phe Val Asp Trp
225 230 235 240

Lys Arg Ser Val Pro Ser Gln Thr Ala Trp Ala Leu Met Gly Leu Val
245 250 255

Ala Ala Gly Arg Ala Ser Gly Ala Ala Ala Gln Arg Ala Ala Ala Trp
260 265 270

Leu Leu Asp Asn Arg Asn Thr Asn Gly Ser Trp Asp Glu Gln Asp Tyr
275 280 285

Thr Gly Thr Gly Phe Pro
290


<210> 306
<211> 294
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 306
Ser Pro Val Trp Asp Thr Pro Trp Thr Val Met Ala Leu Leu Glu Ala
1 5 10 15

Gly Val Pro Ser Asn Asp Pro Ala Leu Leu Arg Ser Gly Arg Trp Leu
20 25 30

Leu Ala Lys Gln Ile Thr Asp Thr Lys Gly Asp Trp Ala Ile Lys Asn
35 40 45

Lys Asn Thr Ala Pro Gly Gly Trp Ser Phe Glu Phe Glu Asn Lys Tyr
50 55 60

Phe Pro Asp Val Asp Asp Thr Ile Glu Val Leu His Cys Leu His Lys
65 70 75 80

Leu Ala Ile Pro Trp Arg Glu Lys Glu Lys Pro Cys Arg Leu Gly Ile
85 90 95

Asp Trp Leu Leu Ser Met Gln Asn Asp Asp Gly Gly Trp Gly Ala Phe
100 105 110

Asp Lys Asn Gln Lys Arg Gln Val Val Asn Arg Ile Pro Phe Ser Asp
115 120 125

His Gly Ala Cys Leu Asp Pro Ser Ser Pro Asp Ile Thr Gly Arg Met
130 135 140

Ile Glu Phe Leu Ala Thr Gln Lys Phe Asn Ser Glu Tyr Glu Ser Val
145 150 155 160

Lys Arg Ala Leu Lys Tyr Ile Trp Lys Thr Gln Glu Asp Phe Gly Gly
165 170 175

Trp His Ala Arg Trp Gly Ile Asn Tyr Ile Tyr Gly Thr Trp Cys Val
180 185 190

Leu Thr Gly Leu Arg Ala Ile Gly Phe Asn Met Thr Asp Arg Arg Val
195 200 205

Gln Lys Ala Leu Asn Trp Leu Glu Ser Ile Gln Asn Lys Asp Gly Gly
210 215 220

Phe Gly Glu Ser Pro Ala Ser Tyr Glu Glu Cys Arg Tyr Ile Pro Trp
225 230 235 240

Lys Glu Ser Val Pro Ser Gln Thr Ala Trp Ala Leu Met Ala Leu Val
245 250 255

Ala Gly Gly Gly Ala Gly Ser Ala Pro Ala Glu Asn Ala Ala Thr Phe
260 265 270

Leu Ile Asn Tyr Arg Asn Ser Asn Gly Val Trp Asp Glu Glu Cys Tyr
275 280 285

Thr Gly Thr Gly Phe Pro
290


<210> 307
<211> 295
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 307
Ser Pro Val Trp Asp Thr Pro Trp Met Ile Glu Ala Leu Leu Glu Thr
1 5 10 15

Gly Val Pro Pro Gly Asp Pro Ala Leu Leu Arg Ala Gly Arg Trp Leu
20 25 30

Met Ser Lys Gln Ile Thr Gly Val Arg Gly Asp Trp Ala Met Lys Ser
35 40 45

Pro Lys Gly Lys Pro Gly Gly Trp Ala Phe Glu Phe Glu Asn Asp Tyr
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ile Gln Val Leu Thr Ala Leu Cys Lys
65 70 75 80

Leu Ser Ile Pro Trp Arg Glu Lys Glu Lys Ala Val Met Gln Gly Ile
85 90 95

Asp Trp Leu Ile Ser Met Gln Asn Asp Asp Gly Gly Trp Gly Ala Phe
100 105 110

Asp Arg Asn Gln Thr Arg Trp Ile Val Asn Arg Ile Pro Phe Ser Asp
115 120 125

His Lys Ala Cys Leu Asp Pro Ser Ser Pro Asp Ile Thr Gly Arg Met
130 135 140

Val Glu Phe Leu Met Arg Arg Asn Tyr Ser Thr Ser His Pro Ser Val
145 150 155 160

Lys Lys Ala Leu Lys Tyr Ile Arg Glu Thr Gln Glu Asp Phe Gly Ala
165 170 175

Trp Phe Ala Arg Trp Gly Ile Asn Tyr Ile Tyr Gly Thr Trp Cys Val
180 185 190

Leu Thr Ala Leu Ala Ala Met Gly Ile Gly His Thr Asp Ser Arg Val
195 200 205

Ala Lys Ala Val Ala Trp Leu Ser Ser Val Gln Arg Pro Asp Gly Gly
210 215 220

Phe Ser Glu Ala Ala Asp Thr Tyr His Pro His Lys Pro Phe Glu Ser
225 230 235 240

Tyr Ser Glu Ser Val Pro Ser Gln Ser Ala Trp Ala Leu Met Gly Leu
245 250 255

Val Ala Gly Gly Ala Val His Ser Pro Ala Ala Ala Arg Ala Ala Cys
260 265 270

Tyr Leu Ile Asn Asn Arg Asn Leu Asn Asn Gly Trp Asp Glu Arg His
275 280 285

Tyr Thr Gly Thr Gly Phe Pro
290 295


<210> 308
<211> 226
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 308
Ser Pro Val Trp Asp Thr Ala Ile Ala Gly Tyr Ala Leu Gly Glu Ser
1 5 10 15

Gly Cys Ala Pro Gln Ser Ala Leu Arg Arg Met Ala Asp Trp Leu Leu
20 25 30

Thr Lys Glu Val Arg Arg Lys Asp Asp Trp Ser Val Lys Arg Pro Asp
35 40 45

Val Glu Pro Ser Gly Trp Tyr Phe Glu Phe Ala Asn Glu Phe Tyr Pro
50 55 60

Asp Thr Asp Asp Thr Ala Met Val Leu Leu Ser Leu Leu His Gly Arg
65 70 75 80

Ala Thr Asn Pro Ala Ala Gln Glu Ala Cys Ala Lys Arg Ala Val Asn
85 90 95

Trp Leu Leu Ala Met Gln Ser Lys Asp Gly Gly Trp Ala Ala Phe Asp
100 105 110

Val Asp Asn Asp Trp Lys Pro Leu Ser Tyr Val Pro Phe Ala Asp His
115 120 125

Asn Ala Met Leu Asp Pro Ser Cys Pro Asp Ile Thr Gly Arg Val Leu
130 135 140

Glu Ala Leu Cys Lys Tyr Gly Val Ser Gln Glu His Pro Ala Val Leu
145 150 155 160

Arg Ala Ile Asp Tyr Leu Ile Gln Thr Gln Glu Gln Asp Gly Ser Trp
165 170 175

His Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Phe Leu Ala Leu
180 185 190

Arg Gly Leu Lys Ala Ala Gly Val Ser Asp Arg Glu Ala Tyr Val Leu
195 200 205

Arg Ala Gly Glu Trp Leu Asp Leu Ile Gln Asn Pro Asp Gly Gly Trp
210 215 220

Gly Glu
225


<210> 309
<211> 226
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 309
Ser Pro Val Trp Asp Thr Val Leu Ser Ile Thr Ala Leu Ala Asp Ala
1 5 10 15

Asp Leu Pro Arg Thr His Pro Ala Met Arg Arg Ala Val Ala Trp Val
20 25 30

Leu Gly Lys Gln Val Leu Cys Glu Gly Asp Trp Arg Val Lys Asn Arg
35 40 45

Arg Gly Glu Pro Gly Gly Trp Ser Phe Glu Phe Asn Asn Asn Phe Tyr
50 55 60

Gln Asp Asn Asp Asp Thr Ala Ala Val Leu Ile Ala Leu His Lys Ala
65 70 75 80

Arg Leu Pro Asp Glu Ala Lys Gly Glu Ala Met Gln Arg Gly Leu Arg
85 90 95

Trp Leu Leu Ser Met Gln Cys Asp Asp Gly Gly Trp Ser Ala Phe Asp
100 105 110

Val Asn Asn Asn Lys Arg Leu Leu Asn Lys Ile Pro Phe Ala Asp Leu
115 120 125

Glu Ser Met Leu Asp Pro Ser Thr Cys Asp Leu Thr Gly Arg Thr Leu
130 135 140

Glu Ala Leu Gly Ser Ile Gly Phe Pro Phe Thr His Arg Ile Val Gln
145 150 155 160

His Ala Val Arg Phe Ile Arg Gln His Gln Glu Ala Asp Gly Ala Trp
165 170 175

Tyr Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Cys His Val Leu
180 185 190

Cys Gly Leu Leu Ser Val Gly Glu Asp Met His Gln Pro Tyr Val Gln
195 200 205

Arg Ala Val Gln Trp Leu Ile Glu His Gln Asn Ala Asp Gly Gly Trp
210 215 220

Gly Glu
225


<210> 310
<211> 226
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 310
Ser Pro Val Trp Asp Thr Ala Leu Ala Val Arg Ala Leu Ala Ala Ala
1 5 10 15

Gly Leu Pro Pro Glu His Pro Ala Met Val Lys Ala Ser Glu Trp Leu
20 25 30

Leu Thr Gln Gln Ile Phe Lys Pro Gly Asp Trp Ser Val Lys Cys Pro
35 40 45

Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe Val Asn Asn Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Ser Met Val Leu Val Ala Leu Lys Glu Gly
65 70 75 80

Leu Ala Asp Ala Ala Lys His Gln Ala Ala Leu Gln Arg Gly Ile Asn
85 90 95

Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Phe Ala Ser Phe Asp
100 105 110

Lys Asp Asn Thr Lys Glu Trp Leu Asn Ala Ile Pro Phe Gly Asp Leu
115 120 125

Lys Ala Leu Val Asp Pro Pro Thr Glu Asp Ile Thr Ala Arg Ile Leu
130 135 140

Glu Met Met Gly Ala Phe Gly His Gly Leu Asp His Pro Val Ala Val
145 150 155 160

Arg Gly Leu Ala Tyr Leu His Gln Thr Gln Arg Pro Glu Gly Pro Trp
165 170 175

Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu
180 185 190

Val Ala Leu Lys Arg Ile Gly Glu Asp Met Ser Arg Pro Tyr Val Arg
195 200 205

Arg Ala Val Asp Trp Val Lys Ala His Gln Asn Pro Asp Gly Gly Trp
210 215 220

Gly Glu
225


<210> 311
<211> 226
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 311
Ser Pro Val Trp Asp Thr Ala Leu Ala Val Arg Ala Leu Ala Ala Ala
1 5 10 15

Gly Leu Pro Pro Glu His Pro Ala Met Val Lys Ala Ser Glu Trp Leu
20 25 30

Leu Thr Gln Gln Ile Phe Lys Pro Gly Asp Trp Ser Val Lys Cys Pro
35 40 45

Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe Val Asn Asn Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Ser Met Val Leu Val Ala Leu Lys Asp Gly
65 70 75 80

Leu Val Asp Ala Ala Lys His Gln Ala Ala Leu Gln Arg Gly Ile Asn
85 90 95

Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Phe Ala Ser Phe Asp
100 105 110

Lys Asp Asn Thr Lys Glu Trp Leu Asn Ala Ile Pro Phe Gly Asp Leu
115 120 125

Lys Ala Leu Val Asp Pro Pro Thr Glu Asp Ile Thr Ala Arg Ile Leu
130 135 140

Glu Met Met Gly Ala Phe Gly His Gly Leu Asp His Pro Val Ala Val
145 150 155 160

Arg Ala Leu Ala Tyr Leu His Gln Thr Gln Arg Pro Glu Gly Pro Trp
165 170 175

Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu
180 185 190

Val Ala Leu Lys Arg Ile Gly Glu Asp Met Asn Arg Pro Tyr Val Arg
195 200 205

Arg Ala Val Asp Trp Val Lys Ala His Gln Asn Leu Asp Gly Gly Trp
210 215 220

Gly Glu
225


<210> 312
<211> 293
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 312
Ser Pro Val Trp Asp Thr Ala Leu Ala Val Arg Ala Leu Ala Ala Ala
1 5 10 15

Gly Val Pro Pro Glu His Pro Ala Met Val Gln Ala Ser Glu Trp Leu
20 25 30

Leu Thr Gln Gln Ile Phe Lys Pro Gly Asp Trp Ser Val Lys Cys Pro
35 40 45

Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe Val Asn Asn Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Ser Met Val Leu Val Ala Leu Lys Asp Gly
65 70 75 80

Leu Ala Asp Ala Ala Lys His Gln Ala Ala Leu Gln Arg Gly Ile Asn
85 90 95

Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Phe Ala Ser Phe Asp
100 105 110

Lys Asp Asn Thr Lys Glu Trp Leu Asn Ala Ile Pro Phe Gly Asp Leu
115 120 125

Lys Ala Leu Val Asp Pro Pro Thr Glu Asp Ile Thr Ala Arg Ile Leu
130 135 140

Glu Met Met Gly Ala Phe Gly His Gly Leu Asp His Pro Val Ala Val
145 150 155 160

Arg Ala Met Ala Tyr Leu His Glu Thr Gln Arg Pro Glu Gly Pro Trp
165 170 175

Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu
180 185 190

Val Ala Leu Lys Arg Ile Gly Glu Asp Met Ser Arg Pro Tyr Val Arg
195 200 205

Arg Ala Val Asp Trp Val Lys Ala His Gln Asn Leu Asp Gly Gly Trp
210 215 220

Gly Glu Cys Cys Glu Ser Tyr Arg Asn Pro Glu Leu Met Gly Arg Gly
225 230 235 240

Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Phe Ala
245 250 255

Ser Gly Glu Val His Thr Pro Glu Val Lys Ala Gly Val Asp Tyr Leu
260 265 270

Val Lys Thr Gln Asn Ser Leu Gly Arg Trp Asp Glu Glu Gln Phe Thr
275 280 285

Gly Thr Gly Phe Pro
290


<210> 313
<211> 226
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 313
Ser Pro Ile Trp Asp Thr Ala Leu Ala Val Arg Ala Leu Thr Ala Ala
1 5 10 15

Gly Met Pro Pro Glu His Pro Ala Met Val Lys Ala Ser Glu Trp Leu
20 25 30

Leu Thr Gln Gln Ile Phe Lys Pro Gly Asp Trp Ser Val Lys Cys Pro
35 40 45

Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe Val Asn Asn Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Ser Met Val Leu Val Ala Leu Lys Glu Gly
65 70 75 80

Leu Ala Asp Thr Ala Lys His Gln Ala Ala Leu Gln Arg Gly Ile Asn
85 90 95

Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Phe Ala Ser Phe Asp
100 105 110

Lys Asp Asn Thr Lys Glu Trp Leu Asn Ala Ile Pro Phe Gly Asp Leu
115 120 125

Lys Ala Leu Val Asp Pro Pro Thr Glu Asp Ile Thr Ala Arg Ile Leu
130 135 140

Glu Met Met Gly Ala Phe Gly His Gly Leu Asp His Pro Val Ala Val
145 150 155 160

Arg Ala Leu Ala Tyr Leu His Glu Thr Gln Arg Pro Gly Gly Pro Trp
165 170 175

Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Trp Ser Val Leu
180 185 190

Val Ala Leu Lys Arg Ile Gly Glu Asp Met Ser Arg Pro Tyr Val Arg
195 200 205

Arg Ala Val Asp Trp Val Lys Asp His Gln Asn Leu Asp Gly Gly Trp
210 215 220

Gly Glu
225


<210> 314
<211> 293
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 314
Ser Pro Val Trp Asp Thr Ala Leu Ala Val Arg Ala Leu Ala Ala Ala
1 5 10 15

Gly Val Pro Pro Glu His Pro Ala Met Val Lys Ala Ser Glu Trp Leu
20 25 30

Leu Thr Gln Gln Ile Phe Lys Pro Gly Asp Trp Ser Ile Lys Cys Pro
35 40 45

Asp Leu Pro Pro Gly Gly Trp Ala Phe Glu Phe Val Asn Asn Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Ser Met Val Leu Val Ala Leu Lys Asp Gly
65 70 75 80

Leu Ala Asp Ala Ala Lys His Gln Ala Ala Leu Gln Arg Gly Ile Asn
85 90 95

Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Phe Ala Ser Phe Asp
100 105 110

Lys Asp Asn Thr Lys Glu Trp Leu Asn Ser Leu Pro Phe Gly Asp Leu
115 120 125

Lys Ala Leu Val Asp Pro Pro Thr Glu Asp Ile Thr Ala Arg Ile Leu
130 135 140

Glu Met Met Gly Ala Phe Gly His Gly Leu Asp His Pro Val Ala Ala
145 150 155 160

Arg Ala Leu Ala Tyr Leu His Gln Thr Gln Arg Pro Glu Gly Pro Trp
165 170 175

Trp Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu
180 185 190

Val Ala Leu Lys Arg Ile Gly Glu Asp Met Ser Arg Pro Tyr Val Arg
195 200 205

Arg Ala Val Asp Trp Val Lys Ala His Gln Asn Pro Asp Gly Gly Trp
210 215 220

Gly Glu Phe Cys Glu Ser Tyr Arg Asn Pro Glu Leu Met Gly Lys Gly
225 230 235 240

Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Phe Ala
245 250 255

Ala Gly Glu Val His Ala Pro Glu Val Thr Ala Gly Val Asp Tyr Leu
260 265 270

Val Lys Thr Gln Asp Ser Leu Gly Arg Trp Asp Glu Glu Gln Phe Thr
275 280 285

Gly Thr Gly Phe Pro
290


<210> 315
<211> 293
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (58)..(58)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (200)..(200)
<223> Xaa can be any amino acid

<400> 315
Ser Pro Val Trp Asp Thr Ala Leu Ala Val Arg Ala Leu Ala Ala Ala
1 5 10 15

Gly Leu Pro Pro Asp His Pro Phe Met Thr Gln Ala Thr Ser Trp Leu
20 25 30

Leu Thr Gln Gln Ile Phe Lys Pro Gly Asp Trp Cys Ile Lys Cys Pro
35 40 45

Asp Leu Pro Pro Gly Gly Trp Ala Phe Xaa Phe His Asn Asn Trp Tyr
50 55 60

Pro Asp Val Asp Asp Ser Ser Met Val Leu Val Ala Leu Lys Asp Gly
65 70 75 80

Leu Pro Asp Thr Ala Arg His Gln Ala Ala Leu Gln Arg Gly Ile Asn
85 90 95

Trp Cys Leu Gly Met Gln Ser Lys Asn Gly Gly Phe Ala Ser Phe Asp
100 105 110

Lys Asp Asn Thr Lys Glu Trp Leu Asn Ala Leu Pro Phe Gly Asp Leu
115 120 125

Lys Ala Leu Val Asp Pro Pro Thr Glu Asp Ile Thr Ala Arg Ile Leu
130 135 140

Glu Met Met Gly Ala Phe Gly His Gly Leu Asp His Pro Thr Ala Asp
145 150 155 160

Arg Ala Leu Ala Phe Leu Arg Arg Thr Gln His Pro Glu Gly Pro Trp
165 170 175

Trp Gly Arg Trp Gly Val Asn Tyr Leu Tyr Gly Thr Trp Ser Val Leu
180 185 190

Val Ala Leu Lys Arg Ile Gly Xaa Asp Met Ser Arg Pro Tyr Val Gln
195 200 205

Arg Ala Val Asn Trp Ile Lys Ser His Gln Asn Pro Asp Gly Gly Trp
210 215 220

Gly Glu Val Cys Glu Ser Tyr Arg His Pro Glu Leu Met Gly Gln Gly
225 230 235 240

Pro Ser Thr Ala Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Leu Ala
245 250 255

Ala Gly Glu Ile Gln Ala Ala Glu Val Lys Ala Gly Val Asp Tyr Leu
260 265 270

Val Lys Thr Gln Asn Ala Gln Gly Arg Trp Asp Glu Lys Tyr Phe Thr
275 280 285

Gly Asn Trp Leu Pro
290


<210> 316
<211> 231
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 316
Ser Pro Val Trp Asp Thr Ala Trp Ala Val Ile Gly Leu Cys Glu Ser
1 5 10 15

Gly Met Glu Arg Thr His Pro Ala Val Arg Ser Ala Ile Arg Trp Leu
20 25 30

Tyr Ser Met Gln Ile Leu Arg Pro Gly Asp Trp Ala Val Lys Asn Pro
35 40 45

Leu Thr Glu Pro Gly Gly Trp Ala Phe Glu Phe His Asn Asp Phe Tyr
50 55 60

Pro Asp Asn Asp Asp Thr Ala Ala Val Leu Met Gly Leu Leu Phe Ser
65 70 75 80

Asp Leu Asn Asp Glu Glu Asn His Arg Ala Phe Glu Arg Gly Val Arg
85 90 95

Trp Leu Leu Ser Met Gln Asn Asn Asp Ser Gly Trp Gly Ala Phe Glu
100 105 110

Arg Asn Val Asp Asn Lys Ile Phe Asp Gln Ile Pro Phe Asn Asp Gln
115 120 125

Lys Asn Met Leu Asp Pro Ser Thr Ala Asp Val Thr Gly Arg Val Val
130 135 140

Glu Leu Leu Gly Arg Ile Gly Arg Arg Leu Gly Gly Ser Phe Ser Asp
145 150 155 160

Glu Pro Tyr Val Arg Gln Ala Ile Glu Phe Leu Lys Asn Glu Gln Glu
165 170 175

Pro Glu Gly Cys Trp Phe Gly Arg Trp Gly Val Asn Tyr Ile Tyr Gly
180 185 190

Thr Trp Ser Val Leu Val Ala Leu Glu Ala Ile Gly Glu Ser Met Arg
195 200 205

Ala Pro Tyr Ile Arg Lys Ala Val Asn Trp Val Lys Lys Val Gln Asn
210 215 220

Pro Asp Gly Gly Trp Gly Glu
225 230


<210> 317
<211> 226
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (105)..(105)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (202)..(202)
<223> Xaa can be any amino acid

<400> 317
Ser Pro Val Trp Asp Thr Ile Leu Gly Met Ile Gly Leu Val Asp Cys
1 5 10 15

Gly His Asp Gly Lys Asp Pro Leu Leu Val Thr Ala Arg Asp Trp Ile
20 25 30

Val Lys Arg Gln Leu Leu Val Asn Tyr Gly Asp Trp Lys Val Tyr Asn
35 40 45

Pro Asn Gly Pro Ser Gly Gly Trp Ser Phe Glu Tyr Asp Asn Ser Trp
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ala Ala Ile Val Ile Gly Phe Leu Lys
65 70 75 80

Gln Asp Tyr Glu Phe Arg His Ser Glu Val Val Lys Arg Ala Cys Asp
85 90 95

Trp Ile Ala Ser Met Gln Asn Gln Xaa Gly Gly Trp Ala Ala Phe Asp
100 105 110

Ile Asn Asn Asp Lys Thr Phe Leu Asn Glu Ile Pro Phe Ser Asp Met
115 120 125

Glu Ser Leu Cys Asp Pro Ser Ser Pro Asp Val Val Gly Arg Val Leu
130 135 140

Glu Ala Phe Gly Ile Leu Asn Asp Pro Lys Tyr Ala Glu Val Cys Arg
145 150 155 160

Arg Gly Ile Glu Tyr Leu Arg Arg Thr Gln Glu Ser Glu Gly Ser Trp
165 170 175

Phe Gly Arg Trp Gly Val Asn Tyr Val Tyr Gly Thr Ser Asn Val Leu
180 185 190

Cys Ser Leu Lys Arg Gln Asp Val Ala Xaa Lys Asp Pro Met Val Thr
195 200 205

Arg Ala Leu Thr Trp Leu Lys Lys Val Gln Asn Lys Asp Gly Gly Trp
210 215 220

Gly Glu
225


<210> 318
<211> 225
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 318
Ser Pro Val Trp Asp Thr Gly Leu Ala Leu His Ala Leu Leu Glu Ser
1 5 10 15

Gly Met Asp Pro Asp Asp Pro Ala Ile Ala Lys Ala Met His Trp Leu
20 25 30

Asp Glu Arg Glu Ile Thr Asp Val Ala Gly Asp Trp Ala Glu Gln Arg
35 40 45

Pro Gly Leu Ala Pro Gly Gly Trp Ala Phe Gln Tyr Arg Asn Asp His
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ala Val Val Gly Met Ala Met His Arg
65 70 75 80

Ala Asn Pro Gln Ala Arg Pro Glu Thr Leu Glu Arg Thr Arg Ala Trp
85 90 95

Ile Glu Gly Met Gln Ser Gln Asn Gly Gly Trp Gly Ala Phe Asp Ala
100 105 110

Asp Asn Thr His Tyr His Leu Asn His Ile Pro Phe Ala Asp His Gly
115 120 125

Ala Met Leu Asp Pro Pro Thr Ala Asp Val Ser Ala Arg Cys Leu Gly
130 135 140

Met Leu Ser Gln Met Gly Tyr Asp Arg Asp His Pro Ser Ile Gln Arg
145 150 155 160

Ala Ile Ala Tyr Leu Lys Asn Asp Gln Glu Glu Asp Gly Ser Trp Phe
165 170 175

Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Val Leu Ser
180 185 190

Ala Leu Asn Ala Ala Gly Glu Asp Met Ser Gln Pro Tyr Ile Arg Lys
195 200 205

Ala Val Asp Tyr Leu Thr Asn Phe Gln Arg Glu Asp Gly Gly Trp Gly
210 215 220

Glu
225


<210> 319
<211> 225
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 319
Ser Pro Val Trp Asp Thr Ser Leu Ser Ala His Ala Leu Met Glu Ala
1 5 10 15

Gly Leu Glu Glu Asn Asp Lys Arg Leu Glu Gly Leu Leu Asp Trp Leu
20 25 30

Lys Asp Leu Gln Ile Leu Asp Val Lys Gly Asp Trp Val Ala Arg Arg
35 40 45

Pro Asp Val Arg Pro Gly Gly Trp Ala Phe Gln Tyr Arg Asn Asp His
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Ala Met His Arg
65 70 75 80

Gln Gly Asp Glu Lys Tyr Lys Glu Ala Ile Asp Arg Ala Ala Glu Trp
85 90 95

Ile Val Gly Met Gln Ser Ser Ser Gly Gly Trp Gly Ala Phe Asp Pro
100 105 110

Glu Asn Glu His Phe Tyr Leu Asn Ser Ile Pro Phe Ala Asp His Gly
115 120 125

Ala Leu Leu Asp Pro Pro Thr Glu Asp Val Thr Ala Arg Cys Val Gly
130 135 140

Phe Leu Ala Gln Leu Asp Pro Asp Ala Tyr Ala Glu Pro Ile Lys Arg
145 150 155 160

Gly Val Glu Phe Leu Lys Arg Thr Gln Gln Glu Asp Gly Ser Trp Trp
165 170 175

Gly Arg Trp Gly Ala Asn Phe Val Tyr Gly Thr Trp Ser Val Leu Cys
180 185 190

Ala Leu Asn Ala Ala Gly Glu Asp Pro Lys Ser Pro Tyr Ile Gln Lys
195 200 205

Ala Val Ala Trp Leu Lys Ser Arg Gln Arg Glu Asp Gly Gly Trp Gly
210 215 220

Glu
225


<210> 320
<211> 225
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (163)..(163)
<223> Xaa can be any amino acid

<400> 320
Ser Pro Val Trp Asp Thr Cys Leu Gly Leu His Ala Leu Leu Glu Ala
1 5 10 15

Gly Glu Pro Arg Glu Ala Pro Ser Val Lys Lys Ala Val Asp Trp Leu
20 25 30

Leu Glu Arg Glu Ile Thr Glu Thr Tyr Gly Asp Trp Val Trp Arg Arg
35 40 45

Pro His Leu Lys Pro Ser Gly Trp Ala Phe Gln Tyr Trp Asn Asn Tyr
50 55 60

Tyr Pro Asp Val Asp Asp Thr Ala Val Val Val Met Ala Leu Asp Arg
65 70 75 80

Val Gly Asp Pro Arg Cys Arg Pro Ala Ile Glu Arg Ala Cys Glu Trp
85 90 95

Ile Ile Gly Met Gln Ser Thr Ser Gly Gly Trp Gly Ser Phe Asp Pro
100 105 110

Glu Asn Glu Phe Thr Tyr Leu Asn His Ile Pro Phe Ala Asp His Gly
115 120 125

Ala Leu Leu Asp Pro Pro Thr Val Asp Val Thr Ala Arg Cys Ile Ser
130 135 140

Met Leu Ala Gln Val Gly Tyr Arg His Asp His Pro Ala Ile Arg Lys
145 150 155 160

Ser Val Xaa Phe Ile Leu Arg Glu Gln Glu Lys Asp Gly Ser Trp Tyr
165 170 175

Gly Arg Trp Gly Thr Asn Tyr Val Tyr Gly Thr Trp Ser Ala Leu Ser
180 185 190

Ala Leu Asn Ala Val Gly Glu Asp Met Ser Ser Pro Val Val Arg Lys
195 200 205

Gly Val Ala Trp Leu Glu Ala Phe Gln Gln Pro Asp Gly Gly Trp Gly
210 215 220

Glu
225


<210> 321
<211> 225
<212> PRT
<213> Unknown

<220>
<223> uncultured organism

<220>
<221> misc_feature
<222> (129)..(129)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (136)..(136)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (193)..(193)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (208)..(208)
<223> Xaa can be any amino acid

<220>
<221> misc_feature
<222> (215)..(215)
<223> Xaa can be any amino acid

<400> 321
Ser Pro Val Trp Asp Thr Gly Ile Ala Cys Gln Ala Leu Gln Glu Val
1 5 10 15

Gly Gly Pro Ala Ala Asp Ala Gly Val Gln Arg Ala Leu Asp Trp Leu
20 25 30

Val Glu Arg Gln Leu Arg Asp Glu Pro Gly Asp Trp Arg Arg Asp Arg
35 40 45

Pro Asp Leu Glu Gly Gly Gly Trp Ala Phe Gln Tyr Asn Asn Pro His
50 55 60

Tyr Pro Asp Leu Asp Asp Thr Ser Met Val Ala Trp Val Met Gln Val
65 70 75 80

Ala Asp His Gly Arg Tyr Arg Glu Glu Ile Arg Arg Ala Ala Lys Trp
85 90 95

Val Val Gly Met Arg Ser Glu Gly Gly Gly Phe Ala Ser Phe Glu Val
100 105 110

Asp Asn Thr Tyr Tyr Tyr Leu Asn His Ile Pro Phe Ala Asp His Gly
115 120 125

Xaa Leu Leu Asp Pro Pro Thr Xaa Asp Val Thr Ala Arg Cys Ile Ala
130 135 140

Val Leu Ala Ile Thr Asp Arg Ala Gln His Glu Thr Val Ile Arg Glu
145 150 155 160

Ala Ile Asp Phe Leu Phe Val Asp Gln Glu Glu Asp Gly Ser Trp Phe
165 170 175

Gly Arg Trp Gly Thr Asp Tyr Ile Tyr Gly Thr Trp Ser Val Leu Ser
180 185 190

Xaa Leu Asp Val Val Gly Phe Asp Met Arg Asp Ala Arg Val Arg Xaa
195 200 205

Ser Val Glu Trp Leu Phe Xaa Gln Gln Asn Pro Asp Gly Gly Trp Gly
210 215 220

Glu
225


<210> 322
<211> 224
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 322
Ser Pro Val Trp Asp Thr Gly Ile Ala Ala His Ala Leu Gly Glu Ala
1 5 10 15

Gly His Ala Ser Ala Met Gln Ser Thr Ala Asp Trp Leu Leu Thr Lys
20 25 30

Glu Val Arg Arg Lys Gly Asp Trp Ser Val Lys Arg Pro Asp Val Glu
35 40 45

Pro Ser Gly Trp Tyr Phe Glu Phe Ala Asn Glu Phe Tyr Pro Asp Ile
50 55 60

Asp Asp Thr Ala Gln Val Leu Leu Gly Leu Ala His Ala Lys Ala Ser
65 70 75 80

Asp Pro Ala Lys Gln Lys Ala Cys Met Asp Arg Ala Val Ala Trp Leu
85 90 95

Leu Ala Met Gln Gly Ser Asp Gly Gly Trp Ala Ala Phe Asp Val Asp
100 105 110

Asn Asn Trp Glu Phe Leu Ser Ser Val Pro Phe Ala Asp His Asn Ala
115 120 125

Met Leu Asp Pro Thr Cys Pro Asp Ile Thr Gly Arg Val Leu Glu Ala
130 135 140

Leu Ala Ala Cys Gly Val Pro Asn Ser His Pro Ala Val Lys Arg Gly
145 150 155 160

Val Glu Phe Leu Arg Asn Ser Val Glu Lys Asp Gly Ser Trp Tyr Gly
165 170 175

Arg Trp Gly Val Asn Tyr Ile Tyr Gly Thr Tyr Leu Ala Leu Arg Gly
180 185 190

Leu Arg Ala Ser Gly Glu Asp Asp Arg Glu Ala His Ile Leu Arg Ala
195 200 205

Gly Glu Trp Leu Arg Ala Ile Gln Asn Ala Asp Gly Gly Trp Gly Glu
210 215 220




<210> 323
<211> 224
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 323
Ser Pro Met Trp Asp Thr Ser Leu Ala Ala His Ala Phe Leu Glu Ser
1 5 10 15

Gly Asp Arg Glu Asp Pro Arg Leu Ile Arg Ala Leu Asp Trp Leu Val
20 25 30

Asp Lys Gln Ile Leu Asp His Val Gly Asp Trp Ala Val Arg Arg Pro
35 40 45

Gly Leu Arg Pro Gly Gly Trp Ala Phe Gln Tyr Glu Asn Pro Asp Tyr
50 55 60

Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Ala Met His Arg Thr
65 70 75 80

Asp Pro Glu Arg Tyr Ala Glu Asn Ile Asp Arg Ala Cys Glu Trp Leu
85 90 95

Ala Gly Met Gln Ser Lys Asn Gly Gly Trp Gly Ala Phe Asp Pro Glu
100 105 110

Asn Glu His Tyr Tyr Leu Asn Ser Ile Pro Phe Ala Asp His Gly Ala
115 120 125

Leu Leu Asp Pro Pro Thr Val Asp Val Thr Ala Arg Cys Ile Gly Cys
130 135 140

Leu Ala Gln Val Asp Ala Glu Ala Phe Ala Asp Asn Ile Lys Arg Gly
145 150 155 160

Ile Gly Phe Ile Lys Arg Glu Gln Glu Pro Asp Gly Ser Trp Phe Gly
165 170 175

Arg Trp Gly Ala Asn Tyr Ile Tyr Gly Thr Trp Ser Ala Leu Val Ala
180 185 190

Leu Lys Gly Ala Gly Glu Asp Met Ser Gln Pro Tyr Ile Arg Lys Ser
195 200 205

Val Ala Trp Leu Lys Gly Arg Gln Gly Pro Asp Gly Gly Trp Gly Glu
210 215 220




<210> 324
<211> 224
<212> PRT
<213> Unknown

<220>
<223> uncultured organism


<400> 324
Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Leu Glu Ala
1 5 10 15

Gly Glu Pro Asn Asp Pro Glu Val Ile Gly Leu Leu Asp Trp Leu Lys
20 25 30

Asp Lys Gln Ile Leu Thr Thr Val Gly Asp Trp Ser Ala Arg Arg Pro
35 40 45

Asn Leu Arg Pro Gly Gly Trp Ala Phe Gln Tyr Glu Asn Pro His Tyr
50 55 60

Pro Asp Val Asp Asp Thr Ala Val Val Ala Met Ala Met His Arg Gln
65 70 75 80

Gly Asp Pro Lys Tyr Ala Glu Ala Ile Ala Arg Ala Cys Glu Trp Leu
85 90 95

Ala Gly Met Gln Ser Ser Ser Gly Gly Trp Gly Ala Phe Asp Pro Glu
100 105 110

Asn Glu His Phe Tyr Leu Asn Ser Ile Pro Phe Ala Asp His Gly Ala
115 120 125

Leu Leu Asp Pro Pro Thr Val Asp Val Thr Ala Arg Cys Val Gly Cys
130 135 140

Leu Ala Gln Val Asp Ala Glu Arg Phe Ala Ser Glu Ile Gln Ala Gly
145 150 155 160

Ile Asp Tyr Ile Lys Arg Glu Gln Glu Glu Asp Gly Ser Trp Phe Gly
165 170 175

Arg Trp Gly Ala Asn Tyr Val Tyr Gly Thr Trp Ser Ala Leu Val Ala
180 185 190

Leu Asn Lys Ala Gly Glu Asp Met Asn Thr Pro Tyr Ile Arg Arg Ala
195 200 205

Val Asp Trp Leu Lys Ala Arg Gln Arg Pro Asp Gly Gly Trp Gly Glu
210 215 220




<210> 325
<211> 640
<212> PRT
<213> Verrucomicrobium spinosum

<400> 325
Met Ala Thr Ser Asp Pro Ser Leu Ala Glu Ala Ile Gln Asn Thr Arg
1 5 10 15

Ala His Leu Leu Ser Leu Arg Asn Ala Arg Gly His Trp Glu Gly His
20 25 30

Leu Ser Asn Ser Ala Leu Ser Thr Ala Thr Ala Ile Val Ala Leu His
35 40 45

Leu Val Asp Ala Pro Leu His Ser Ala Arg Ile Ala Gln Gly Val Arg
50 55 60

Trp Leu Val Leu His Gln Asn Lys Asp Gly Gly Trp Gly Asp Thr Thr
65 70 75 80

Leu Ser Lys Ser Asn Leu Ser Thr Thr Leu Leu Cys Trp Ser Ala Leu
85 90 95

Ser Leu Cys Glu Pro Asp Arg Thr Glu Pro Ile Gln His Cys Glu Ala
100 105 110

Trp Ile Lys Glu Arg Thr Gly Ser Leu Glu Pro Glu Val Ile Cys Arg
115 120 125

Ala Val Val Ala Arg Tyr Gly Lys Asp Lys Thr Phe Ser Val Pro Ile
130 135 140

Leu Met Leu Cys Ala Ile Gly Gly Arg Leu Gly Pro Glu Lys Glu Ala
145 150 155 160

Trp Ser Arg Val Leu Ala Leu Pro Phe Glu Leu Ala Ala Met Pro Arg
165 170 175

Glu Trp Phe Gly Ala Ile Gly Leu Pro Val Val Ser Tyr Ala Leu Pro
180 185 190

Ala Leu Ile Ala Ile Gly Tyr Ala Arg Phe Tyr His Ala Pro Pro Ser
195 200 205

Leu Leu Asn Pro Leu His Ala Leu Arg Lys Ala Leu Trp Pro Arg Ile
210 215 220

Ser Pro Met Leu Lys Leu Leu Gln Pro Ser Thr Gly Gly Tyr Leu Glu
225 230 235 240

Ala Thr Pro Leu Thr Ser Phe Val Thr Met Ala Leu Ala Ser Ala Gly
245 250 255

Glu Lys Phe His Pro Cys Val Pro Glu Ala Val Arg Phe Leu Glu Asp
260 265 270

Ser Gln Arg Pro Asp Gly Ser Trp Pro Ile Asp Thr Asn Leu Ala Thr
275 280 285

Trp Gly Thr Thr Leu Ser Thr Lys Ala Leu Thr Ala Thr Ser Glu Gly
290 295 300

Arg Glu Ala Leu Asp Ile Pro Ala Leu Lys Ser Trp Leu Leu Glu Gln
305 310 315 320

Gln Tyr Gln Glu Ile His Pro Phe Thr Asn Ala Ala Pro Gly Gly Trp
325 330 335

Ala Trp Thr Asp Leu Pro Gly Gly Val Pro Asp Ala Asp Asp Thr Ser
340 345 350

Gly Ala Leu Val Ala Leu Trp His Leu Cys Glu Asp Glu Ala Glu Arg
355 360 365

Gln Ala Leu Ala Pro Ala Val Ala Lys Gly Val Gln Trp Leu Met Asp
370 375 380

Leu Gln Asn Arg Asp Gly Gly Ile Pro Thr Phe Cys Arg Gly Trp Gly
385 390 395 400

Thr Leu Pro Phe Asp Arg Ser Thr Pro Glu Ile Thr Ala His Ala Leu
405 410 415

His Ala Trp Gly Leu Trp Gln Val Val Leu Pro Glu Glu Leu Gln Gln
420 425 430

Glu Val Ser Leu Arg Ile Pro Arg Ala Ile Ala Phe Ile Ala Arg Pro
435 440 445

Pro Ser Arg Gly Ala Pro Gly Phe Asn His Val Pro Leu Trp Phe Gly
450 455 460

Asn Glu His Ala Lys Glu Glu Glu Asn His Val Tyr Gly Thr Ala Gln
465 470 475 480

Ile Met Asn His Leu Leu Ser Ser Gly Leu Asn Thr Pro Glu Ile Lys
485 490 495

Val Ile Leu Glu Thr Gly His Arg Asn Leu Leu Ala Trp Gln Gln Leu
500 505 510

Asp Gly Gly Trp Ser Gly Ser Glu Thr Gly Pro Ala Ser Leu Glu Glu
515 520 525

Thr Ala Val Ser Val Ala Ala Leu Ala Leu His Thr Leu His Ala Gly
530 535 540

Asn Arg Thr Arg Ser Ser Ala Glu Asp Ala Val Ala Lys Gly Thr Gln
545 550 555 560

Trp Leu Val Gln His Thr Ala Thr Gly Thr Thr Phe Pro Ser Ala Pro
565 570 575

Ile Gly Leu Tyr Phe Ala Arg Leu Trp Tyr His Glu Gln Leu Tyr Pro
580 585 590

Val Ile Trp Thr Leu Gly Ala Leu His Ala Val Glu Thr Leu Ser Ala
595 600 605

Ala Ala Leu Pro Leu Arg Ala Arg Ala Ser Ala Pro Pro Gln His Pro
610 615 620

Gly Val Val Arg Thr Lys Pro Ile His Ile Ala Pro Pro Ser Asp Pro
625 630 635 640




<210> 326
<211> 649
<212> PRT
<213> Acidiphilium cryptum

<400> 326
Met Phe Asp Thr Ile Ser Phe Asp Phe Asp Ala Leu Asp Gln Ala Ile
1 5 10 15

Ser Arg Ala His Ala Arg Leu Ser Ala Glu Gln Arg Ala Asp Gly His
20 25 30

Tyr Val Tyr Glu Leu Glu Ala Asp Ala Thr Ile Pro Ala Glu Tyr Val
35 40 45

Leu Leu Glu His Phe Leu Asp Arg Ile Asp Pro Glu Leu Glu Ala Arg
50 55 60

Ile Gly Val Phe Leu Arg Gly Ile Gln Gly Asn Ser Pro Gln Asn Pro
65 70 75 80

Gly Gly Trp Pro Leu Phe His Asp Gly Ala Met Asp Ile Ser Ala Ser
85 90 95

Val Lys Ala Tyr Phe Ala Leu Lys Ala Ile Gly Asp Asp Pro Asp Ala
100 105 110

Pro His Met Arg Arg Ala Arg Glu Ala Ile Leu Ala Arg Gly Gly Ala
115 120 125

Ala Arg Thr Asn Val Phe Thr Arg Ile Gln Leu Ala Leu Phe Gly Ala
130 135 140

Val Pro Trp Arg Ala Cys Pro Val Met Pro Val Glu Ile Met Leu Leu
145 150 155 160

Pro Asp Trp Phe Pro Ile Thr Ile Trp Lys Ile Ser Tyr Trp Ser Arg
165 170 175

Thr Val Ile Ala Pro Leu Leu Val Leu Leu Thr Glu Arg Pro Ile Ala
180 185 190

Arg Asn Pro Arg Asn Val Arg Ile Asp Glu Leu Phe Val Thr Pro Pro
195 200 205

Asp Gln Val Thr Asp Tyr Ile Arg Gly Pro Tyr Arg Ser Asn Trp Gly
210 215 220

Tyr Leu Phe Lys Ala Ile Asp Ser Ala Leu Arg Pro Leu Glu Arg His
225 230 235 240

Phe Pro Ala Arg Ser Arg Lys Arg Ala Ile Gln Ala Ala Ile Asp Phe
245 250 255

Ile Thr Pro Arg Leu Asn Gly Glu Asp Gly Leu Gly Ala Ile Tyr Pro
260 265 270

Ala Met Ala Asn Thr Val Met Met Tyr His Thr Leu Gly Tyr Ser Pro
275 280 285

Asp His Pro Asp Tyr Ala Thr Ala Trp Ala Ser Val Arg Lys Leu Val
290 295 300

Thr Asp Ala Ser Tyr Arg Phe Glu Gly Ala Ser Tyr Val Gln Pro Cys
305 310 315 320

Leu Ser Pro Val Trp Asp Thr Ser Leu Ala Ala His Ala Leu Ala Glu
325 330 335

Ala Gly Ser Pro Gly Asp Ala Gln Leu Ala Ala Ala Cys Asp Trp Leu
340 345 350

Ile Pro Arg Gln Ile Leu Asp Val Lys Gly Asp Trp Ala Tyr Arg Lys
355 360 365

Pro Asp Ala Pro Pro Gly Gly Trp Ala Phe Gln Tyr Asn Asn Ala His
370 375 380

Tyr Pro Asp Val Asp Asp Thr Ala Val Val Gly Met Ile Leu Asp Arg
385 390 395 400

Asn Gly Asp Pro Ala His Arg Glu Ala Val Glu Arg Ala Arg Gln Trp
405 410 415

Ile Leu Gly Met Gln Ser Arg Ser Gly Gly Trp Gly Ala Phe Asp Ser
420 425 430

Asp Asn Glu Phe His Tyr Leu Asn His Ile Pro Phe Ala Asp His Gly
435 440 445

Ala Leu Leu Asp Pro Pro Thr Ala Asp Val Thr Ala Arg Cys Ile Ser
450 455 460

Phe Leu Ala Gln Leu Gly His Ala Glu Asp Arg Pro Ala Ile Glu Arg
465 470 475 480

Gly Val Ala Tyr Leu Arg Arg Glu Gln Glu Gln Asp Gly Ser Trp Phe
485 490 495

Gly Arg Trp Gly Thr Asn Tyr Ile Tyr Gly Thr Trp Ser Ser Leu Cys
500 505 510

Ala Leu Asn Ala Ala Gly Val Ala Gln Asp Asp Pro Met Met Val Arg
515 520 525

Ala Val Glu Trp Leu Leu Ala Arg Gln Arg Pro Asp Gly Gly Trp Gly
530 535 540

Glu Asp Cys Glu Thr Tyr Ala His Ala Lys Pro Gly Glu Tyr His Glu
545 550 555 560

Ser Leu Pro Ser Gln Thr Ala Trp Ala Leu Leu Gly Leu Met Ala Ala
565 570 575

Gly Gln Ala Glu His Glu Ala Val Ala Arg Gly Ile Ala Trp Leu Gln
580 585 590

Ser Val Gln Glu Asp Asp Gly Ser Trp Thr Glu Gln Pro Tyr Asn Ala
595 600 605

Val Gly Phe Pro Arg Val Phe Tyr Leu Arg Tyr His Gly Tyr Pro Arg
610 615 620

Phe Phe Pro Leu Leu Ala Met Ala Arg Tyr Arg Asn Leu Ala Arg Gly
625 630 635 640

Asn Ser Arg Gln Val Gln Phe Gly Phe
645


<210> 327
<211> 25
<212> DNA
<213> Artificial

<220>
<223> PCR Primer

<400> 327
gcgctgtttc atatgggtat tgaca 25


<210> 328
<211> 25
<212> DNA
<213> Artificial

<220>
<223> PCR Primer

<400> 328
gcgcttaccc tggatcctcg aaaat 25

Claims (15)

1. 立体異性的に純粋な形態での、又は立体異性体の混合物としての一般式II
   

   

   (式中、R¹、R²、R³及びR⁴は、互いに独立して、H又はC₁～C₄アルキルを表する)
   の化合物の生物触媒製造のための方法であって、
   前記化合物を、多価不飽和カルボン酸、特にホモファルネシル酸を環化することができるタンパク質と接触させる、方法。
2. 式Iの化合物を、スクアレン-ホペンシクラーゼ(SHC)の酵素活性を持つタンパク質と接触させる、請求項1に記載の方法。
3. 使用される基質が、特に本質的に立体異性的に純粋な形態の一般式I
   

   

   (式中、R¹、R²、R³及びR⁴は上述の意味を有する)
   の多価不飽和カルボン酸である、請求項1又は2に記載の方法。
4. 式Ia
   

   

   のホモファルネシル酸が、出発物質として、特に本質的に立体異性的に純粋な形態で、好ましくは、存在するホモファルネシル酸異性体の総量に基づいて、少なくとも70モル%、特に好ましくは少なくとも75、80又は85モル%、最も好ましくは90、95又は99モル%の(3E,7E)-ホモファルネシル酸の割合で使用される、請求項1から3のいずれか一項に記載の方法。
5. 式IIa
   

   

   のスクラレオリドが、立体異性的に純粋な形態で、又は立体異性体の混合物として得られる、請求項4に記載の方法。
6. 前記SHCが、
   a)配列番号2のアミノ酸配列を有するポリペプチドを含むタンパク質、
   b)配列番号2によるアミノ酸配列に対して、少なくとも45%の配列同一性を有するポリペプチドを含む、a)に由来したタンパク質の欠失、挿入、置換、付加、逆位、又は組合せによるタンパク質、及び
   c)a)又はb)と機能的に同等であり、ホモファルネシル酸のスクラレオリドへの環化を触媒するタンパク質
   から選択される、請求項1から5のいずれか一項に記載の方法。
7. 生物触媒による変換が、
   a)およそ4～5.8、特に4.5～5.5の範囲内の反応媒体のpH値で行われ、以下のさらなる条件:
   b)少なくとも15mM、特に15～30mMの基質濃度、
   c)少なくとも5mg/mlの酵素濃度、
   d)32～40℃、特に35～38℃の範囲内の反応温度、
   e)1～20mMのMgCl₂を含むクエン酸ナトリウム緩衝液中、及び/又は
   f)およそ10～100mMの緩衝液濃度
   のうちの少なくとも1つの下で行われる、請求項1から6のいずれか一項に記載の方法。
8. 酵素のシクラーゼ活性、特にSHCの活性が:
   a)遊離の、場合により部分的又は完全に精製された天然又は組換え的に生成されたシクラーゼ、
   b)固定化された形態のa)によるシクラーゼ、
   c)少なくとも1つのシクラーゼを含む完全な細胞、
   d)c)による細胞の細胞溶解物又は細胞ホモジネートから選択される形態で存在する、請求項1から7のいずれか一項に記載の方法。
9. 変換が、1相の水性系又は2相の水-有機系又は固体-液体系で行われる、請求項1から8のいずれか一項に記載の方法。
10. 変換が、37℃の範囲内の温度及び5～5.2の範囲内のpH値で行われる、請求項1から9のいずれか一項に記載の方法。
11. SHCが、メチロコッカス・カプサラツス、ロドシュードモナス・パルストリス、ブラジリゾビウム・ジャポニカム、フランキア属の種、ストレプトマイセス・セリカラー、特にザイモモナス・モビリスから選択される微生物から単離される、請求項1から10のいずれか一項に記載の方法。
12. SHCが、エシェリキア属、コリネバクテリウム属、ラルストニア属、クロストリジウム属、シュードモナス属、バチルス属、ザイモモナス属、ロドバクター属、ストレプトマイセス属、バークホルデリア属、ラクトバチルス属及びラクトコッカス属、特にエシェリキア属の細菌の中から選択されるSHCを過剰発現する微生物から単離される、請求項1から11のいずれか一項に記載の方法。
13. SHCが、大腸菌、シュードモナス・プチダ、バークホルデリア・グルマエ、ストレプトマイセス・リビダンス、ストレプトマイセス・セリカラー及びザイモモナス・モビリス、特に大腸菌の種のトランスジェニックなSHC過剰発現細菌から単離される、請求項1から12のいずれか一項に記載の方法。
14. 3a,6,6,9a-テトラメチルドデカヒドロナフト[2,1-b]フラン(アンブロキシド)の製造方法であって、
    a)ホモファルネシル酸を、請求項1から13のいずれか一項に記載の方法によってスクラレオリドに変換し、
    b)工程a)の生成物をアンブロキシジオールに化学的に還元し、
    c)工程b)からのアンブロキシドールを化学的にアンブロキシドに環化する、方法。
15. アンブロキシドが、(-)-アンブロキシド((3aR,5aS,9aS,9bR)-3a,6,6,9a-テトラメチルドデカヒドロナフト[2,1-b]フラン[CAS 6790-58-5])である、請求項14に記載の方法。

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