JP2023537066A5 - - Google Patents

Info

Publication number
JP2023537066A5
JP2023537066A5 JP2023508513A JP2023508513A JP2023537066A5 JP 2023537066 A5 JP2023537066 A5 JP 2023537066A5 JP 2023508513 A JP2023508513 A JP 2023508513A JP 2023508513 A JP2023508513 A JP 2023508513A JP 2023537066 A5 JP2023537066 A5 JP 2023537066A5
Authority
JP
Japan
Prior art keywords
cancer
item
kit according
alkyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023508513A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023537066A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/045100 external-priority patent/WO2022032191A1/en
Publication of JP2023537066A publication Critical patent/JP2023537066A/ja
Publication of JP2023537066A5 publication Critical patent/JP2023537066A5/ja
Pending legal-status Critical Current

Links

JP2023508513A 2020-08-07 2021-08-06 トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 Pending JP2023537066A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063062814P 2020-08-07 2020-08-07
US63/062,814 2020-08-07
PCT/US2021/045100 WO2022032191A1 (en) 2020-08-07 2021-08-06 Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy

Publications (2)

Publication Number Publication Date
JP2023537066A JP2023537066A (ja) 2023-08-30
JP2023537066A5 true JP2023537066A5 (OSRAM) 2024-08-14

Family

ID=77543672

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023508513A Pending JP2023537066A (ja) 2020-08-07 2021-08-06 トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用

Country Status (5)

Country Link
US (2) US12589162B2 (OSRAM)
EP (2) EP4295917A3 (OSRAM)
JP (1) JP2023537066A (OSRAM)
CN (1) CN116056765A (OSRAM)
WO (1) WO2022032191A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250186592A1 (en) 2021-10-29 2025-06-12 Tambo, Inc. Tetrazine conjugates for in vivo targeted delivery of a payload
EP4590342A1 (en) 2022-09-20 2025-07-30 VALANX Biotech GmbH Click-to-release on proteins and peptides
CN121001752A (zh) * 2023-02-21 2025-11-21 坦博公司 反式环辛烯缀合物
CN121419788A (zh) 2023-05-04 2026-01-27 坦博公司 用于体内递送有效载荷的基于四嗪的靶向剂
CN121419790A (zh) 2023-05-18 2026-01-27 坦博公司 反式环辛烯修饰的靶向性蛋白质降解剂缀合物
AU2024300552A1 (en) * 2023-07-27 2026-01-29 Veraxa Biotech Gmbh Hydrophilic trans-cyclooctene (hytco) compounds, constructs and conjugates containing the same
WO2025059685A1 (en) 2023-09-15 2025-03-20 Tambo, Inc. Methods for in vivo targeted delivery of a payload

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73534A (en) 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
WO1995031223A1 (en) 1994-05-13 1995-11-23 Kuraray Co., Ltd. Medical polymer gel
US7662368B2 (en) 1999-07-16 2010-02-16 Institut Pasteur Method of inducing SHC phosphorylation of inducing the SHC/MAPK pathway by administering a peptide of IL-2
ATE500838T1 (de) 2000-09-08 2011-03-15 Amylin Pharmaceuticals Inc ßPSEUDOß-NATIVE CHEMISCHE LIGATION
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
ATE394412T1 (de) 2001-06-21 2008-05-15 Clontech Lab Inc Wasserlösliche polymere zusammensetzungen mit affinität für metallionen und verfahren zu deren anwendung
WO2003084571A1 (en) 2002-04-08 2003-10-16 Denki Kagaku Kogyo Kabushiki Kaisha Therapeutic composition for bone infectious disease
US7445894B2 (en) 2002-05-03 2008-11-04 Molecular Probes, Inc. Compositions and methods for detection and isolation of phosphorylated molecules
KR101145506B1 (ko) 2003-05-20 2012-05-15 이뮤노젠 아이엔씨 새로운 메이탠시노이드를 포함하는 개선된 세포독성체
EP1942950A2 (en) 2005-11-01 2008-07-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Biodegradable composite for internal local radiotherapy
US7919079B2 (en) 2006-03-31 2011-04-05 Biosante Pharmaceuticals, Inc. Cancer immunotherapy compositions and methods of use
JPWO2007119815A1 (ja) 2006-04-14 2009-08-27 協和発酵キリン株式会社 Toll様受容体9作動薬
EP1867638A1 (de) 2006-06-16 2007-12-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
US8236949B2 (en) 2007-07-17 2012-08-07 University Of Delaware Tetrazine-based bio-orthogonal coupling reagents and methods
ES2539353T3 (es) 2007-08-01 2015-06-30 Idera Pharmaceuticals, Inc. Nuevos agonistas sintéticos de TLR9
JP2011503111A (ja) 2007-11-12 2011-01-27 バイパー サイエンシズ,インコーポレイティド Parp阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療
WO2011127149A1 (en) 2010-04-06 2011-10-13 University Of Utah Research Foundation Controlled release combination biomaterials
US8574629B2 (en) 2008-08-01 2013-11-05 Anteis S.A. Injectable hydrogel with an enhanced remanence and with an enhanced ability to create volume
WO2010051530A2 (en) 2008-10-31 2010-05-06 The General Hospital Corporation Compositions and methods for delivering a substance to a biological target
CN102215820A (zh) 2008-11-17 2011-10-12 安龙制药公司 用于核酸输送系统的可释放融合脂质
RU2011135993A (ru) 2009-01-30 2013-03-10 Идера Фармасьютикалз, Инк. Новые синтетические агонисты tlr9
BRPI1006246A2 (pt) 2009-04-16 2020-02-04 Koninl Philips Electronics Nv "kit para imagem médica marcada e/ou terapias, sonda efetora e método"
EP2360167A1 (en) 2010-02-03 2011-08-24 Deutsches Krebsforschungszentrum Post-synthetic modification of nucleic acids by inverse Diels-Alder reaction
WO2012012612A2 (en) 2010-07-23 2012-01-26 University Of Delaware Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes
RU2013121799A (ru) 2010-10-14 2014-11-20 Конинклейке Филипс Электроникс Н.В. Набор для претаргетинга, способ и агенты, применяемые в нем
WO2012074840A2 (en) 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
EP2654796A1 (en) 2010-12-21 2013-10-30 Koninklijke Philips N.V. Agents for clearing biomolecules from circulation
EP2522369A1 (en) 2011-05-09 2012-11-14 Koninklijke Philips Electronics N.V. Pretargeting kit, method and agents used therein
EP2709666B1 (en) 2011-05-16 2021-07-14 Koninklijke Philips N.V. Bio-orthogonal drug activation
WO2012165462A1 (ja) 2011-05-31 2012-12-06 国立大学法人 東京大学 ハイドロゲル及びその製造方法
ES2393602B1 (es) 2011-06-09 2013-10-02 Universidad Complutense De Madrid Materiales biocerámicos para el tratamiento de la osteomielitis.
WO2013115885A2 (en) 2011-11-22 2013-08-08 The Regents Of The University Of Michigan Synthesizing functionalized dendrimers within biological settings
CA2865578C (en) 2012-02-27 2023-01-17 Amunix Operating Inc. Xten conjugate compositions and methods of making same
US9206271B2 (en) 2012-03-25 2015-12-08 Wisconsin Alumni Research Foundation Fully backbone degradable and functionalizable polymers derived from the ring-opening metathesis polymerization (ROMP)
WO2013187954A1 (en) 2012-06-12 2013-12-19 The General Hospital Corporation Magnetic labeling of bacteria
WO2014065860A1 (en) 2012-10-24 2014-05-01 The General Hospital Corporation Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
EP2922574B1 (en) 2012-11-22 2023-05-17 Tagworks Pharmaceuticals B.V. Chemically cleavable group
WO2014081300A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Channel protein activatable liposomes
WO2014081299A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Activatable liposomes
WO2014081301A1 (en) 2012-11-22 2014-05-30 Tagworks Pharmaceuticals B.V. Bio-orthogonal drug activation
EA201590396A1 (ru) 2012-12-13 2015-12-30 Адуро Биотек, Инк. Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения
WO2014117001A1 (en) 2013-01-25 2014-07-31 Memorial Sloan-Kettering Cancer Center Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides
WO2014138186A1 (en) 2013-03-05 2014-09-12 The Johns Hopkins University Bioorthogonal two-component delivery systems for enhanced internalization of nanotherapeutics
KR102210895B1 (ko) 2013-03-08 2021-02-02 폴리액티바 피티와이 리미티드 생리활성 물질의 전달을 위한 폴리머 결합체
ME03586B (me) 2013-05-18 2020-07-20 Univ California Sastavi i metode za aktiviranje signaliziranja koje je zavisno od .,stimulatora gena za interferon"
WO2014189806A1 (en) 2013-05-18 2014-11-27 Aduro Biotech, Inc. Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling
JP6600302B2 (ja) 2013-06-12 2019-10-30 ザ ジェネラル ホスピタル コーポレイション 標的分子のマルチプレックス検出のための方法、キット、およびシステム、ならびにそれらの使用
WO2014205126A1 (en) 2013-06-19 2014-12-24 The Regents Of The University Of California Chemical structures for localized delivery of therapeutic agents
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
EP3071209A4 (en) 2013-11-19 2017-08-16 The University of Chicago Use of sting agonist as cancer treatment
AU2015210750B2 (en) 2014-01-31 2020-08-20 Children's Medical Center Corporation Antibody molecules to TIM-3 and uses thereof
WO2015117235A1 (en) 2014-02-10 2015-08-13 Mcmaster University Targeted molecular imaging contrast agents
WO2015138920A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
CN106659796B (zh) 2014-03-14 2021-04-30 加利福尼亚大学董事会 Tco缀合物和治疗剂递送方法
ES2871029T3 (es) 2014-04-04 2021-10-28 Harvard College Dispositivos de liberación de fármacos recargables y procedimientos de uso de los mismos
ES2951908T3 (es) 2014-04-04 2023-10-25 Harvard College Hidrogeles reticulados por química clic y métodos de uso
WO2015185565A1 (en) 2014-06-04 2015-12-10 Glaxosmithkline Intellectual Property Development Limited Cyclic di-nucleotides as modulators of sting
WO2016014799A1 (en) 2014-07-23 2016-01-28 University Of Iowa Research Foundation Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy
GB201501462D0 (en) 2015-01-29 2015-03-18 Glaxosmithkline Ip Dev Ltd Novel compounds
JO3746B1 (ar) 2015-03-10 2021-01-31 Aduro Biotech Inc تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون"
AU2016270782B2 (en) 2015-05-29 2021-08-12 Dynavax Technologies Corporation Intrapulmonary administration of polynucleotide toll-like receptor 9 agonists for treating cancer of the lung
IL256652B2 (en) 2015-06-29 2026-03-01 Verastem Inc Dapatinib in combination with an anti-PD1 antibody, anti-PDL1 antibody, or anti-PD1 ligand for use in the treatment of cancer
MX2018001814A (es) 2015-08-13 2018-05-07 Merck Sharp & Dohme Compuestos dinucleotidos ciclicos como agonistas del estimulador de genes de interferon.
JP6823067B2 (ja) 2015-09-10 2021-01-27 タンボ・インコーポレイテッド 生体直交型組成物
UY36969A (es) 2015-10-28 2017-05-31 Novartis Ag Composiciones y métodos para activar la señalización dependiente del estimulador del gen de interferon
JP6411676B2 (ja) 2015-12-03 2018-10-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited Stingの調節因子としての環状プリンジヌクレオチド
HUE073018T2 (hu) 2016-01-11 2026-01-28 Innate Tumor Immunity Inc Ciklikus dinukleotidok állapotok kezelésére, amelyek STING-aktivitással kapcsolatosak, mint például rák
KR102775461B1 (ko) 2016-04-01 2025-02-28 어비디티 바이오사이언시스 인크. 핵산-폴리펩타이드 조성물 및 이의 용도
EP3448260A4 (en) * 2016-04-27 2019-10-09 Immunomedics, Inc. EFFICACY OF ANTI-TROP-2 SN-38 ANTIBODY CONJUGATES FOR THE THERAPY OF REZIDIVATED / REFRACTORY TUMORS AGAINST CHECKPOINT INHIBITORS
EP3507367A4 (en) 2016-07-05 2020-03-25 Aduro BioTech, Inc. CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
KR102569881B1 (ko) 2016-07-06 2023-08-22 에프-스타 테라퓨틱스 인코포레이티드 질병 치료용 화합물, 조성물 및 방법
TW201803886A (zh) 2016-07-06 2018-02-01 史貝羅威生物科學有限公司 化合物、組合物及用於治療疾病之方法
EP3484504A4 (en) 2016-07-15 2020-07-29 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT OF DISEASE
WO2018013887A1 (en) 2016-07-15 2018-01-18 Sperovie Biosciences, Inc. Compounds, compositions, and methods for the treatment of disease
US10537590B2 (en) 2016-09-30 2020-01-21 Boehringer Ingelheim International Gmbh Cyclic dinucleotide compounds
US10414747B2 (en) 2016-10-04 2019-09-17 Merck Sharp & Dohme Corp. Benzo[b]thiophene compounds as sting agonists
JOP20170188A1 (ar) 2016-11-25 2019-01-30 Janssen Biotech Inc ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
PT3512861T (pt) 2016-12-01 2021-04-29 Takeda Pharmaceuticals Co Dinucleotídeos cíclicos
AU2017378783A1 (en) 2016-12-20 2019-07-04 Merck Sharp & Dohme Corp. Cyclic dinucleotide sting agonists for cancer treatment
JP7213188B2 (ja) 2017-01-27 2023-01-26 ヤンセン バイオテツク,インコーポレーテツド Stingアゴニストとしての環状ジヌクレオチド
US11492367B2 (en) 2017-01-27 2022-11-08 Janssen Biotech, Inc. Cyclic dinucleotides as sting agonists
JOP20190218A1 (ar) 2017-03-22 2019-09-22 Boehringer Ingelheim Int مركبات ثنائية النيوكليوتيدات حلقية معدلة
ES2983582T3 (es) 2017-04-07 2024-10-23 Tambo Inc Composiciones bioortogonales
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
WO2018208667A1 (en) 2017-05-12 2018-11-15 Merck Sharp & Dohme Corp. Cyclic di-nucleotide compounds as sting agonists
JP2020524717A (ja) 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドCuradev Pharma Limited ヒトstingの小分子調節因子
JP2020524718A (ja) 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドCuradev Pharma Limited ヒトstingの複素環式小分子調節因子
CA3067257A1 (en) 2017-06-22 2018-12-27 Curadev Pharma Limited Small molecule modulators of human sting
JP2020530838A (ja) 2017-08-04 2020-10-29 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト
US11638716B2 (en) 2017-08-31 2023-05-02 F-star Therapeutics, Inc. Compounds, compositions, and methods for the treatment of disease
WO2019051489A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
WO2019051488A1 (en) 2017-09-11 2019-03-14 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
AR114990A1 (es) 2017-11-02 2020-11-18 Alios Biopharma Inc Constructos de oligonucleótidos y usos de los mismos
MX2020004858A (es) 2017-11-10 2020-10-01 Takeda Pharmaceuticals Co Compuestos moduladores de sting y metodos de elaboracion y uso.
CN111801419A (zh) 2017-12-15 2020-10-20 拜耳动物保健有限责任公司 免疫刺激性寡核苷酸
EP3724205B1 (en) 2017-12-15 2022-06-22 Janssen Biotech, Inc. Cyclic dinucleotides as sting agonists
WO2019123338A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'2' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
EP3727401A4 (en) 2017-12-20 2022-04-06 Merck Sharp & Dohme Corp. CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
JP7098748B2 (ja) 2017-12-20 2022-07-11 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. Stingアダプタータンパク質を活性化するホスホン酸結合を有する2’3’環状ジヌクレオチド
KR102492187B1 (ko) 2017-12-20 2023-01-27 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 3'3' 사이클릭 다이뉴클레오티드
CA3099421C (en) * 2018-05-04 2025-05-06 Tagworks Pharmaceuticals B.V. COMPOUNDS INCLUDING A BINDER TO INCREASE TRANSCYCLOOCTENE STABILITY
JP7622031B2 (ja) * 2019-07-05 2025-01-27 タンボ・インコーポレイテッド トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
CN110496233B (zh) * 2019-09-05 2022-07-19 复旦大学附属中山医院 一种spect显像剂及其标记前体及其制备方法、组合物和用途

Similar Documents

Publication Publication Date Title
KR102751026B1 (ko) 엑사테칸 유도체, 링커-페이로드 및 이의 접합체
AU2012244675B2 (en) Novel binder-drug conjugates (ADCs) and their use
JP2025510629A (ja) カンプトテシンコンジュゲート
JP2020525542A5 (OSRAM)
AU2015243379B2 (en) Tubulysin derivatives
CN101340947B (zh) Iap-抑制剂和紫杉烷7的组合
CN103327977B (zh) 恶液质的治疗或预防剂
JP2014512375A5 (OSRAM)
JP2020506951A5 (OSRAM)
JP2020516621A5 (OSRAM)
JP2024174998A5 (OSRAM)
MX2014007121A (es) Nuevos conjugados de principio activo-ligante (adc) y su uso.
WO2018178060A1 (en) HDAC INHIBITORS-BASED ANTIBODY DRUG CONJUGATES (ADCs) AND USE IN THERAPY
EA035374B1 (ru) Антитела против cd48 и их конъюгаты
JP2017537893A5 (OSRAM)
JP2009512719A5 (OSRAM)
KR101993963B1 (ko) 항 종양제 및 항 종양 효과 증강제
JP2014210790A (ja) 液性腫瘍を治療するための方法および組成物
JP2024543016A5 (OSRAM)
WO2022159650A1 (en) HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF eEF1A2
AU2022291381B2 (en) Combination mcl-1 inhibitors with anti-cancer agents
RU2016123855A (ru) Ингибиторы протеинкиназы
TW200400820A (en) Camptothecin-taxoid conjugates as antimitotic and antitumor agents
RU2016124366A (ru) Ингибиторы протеинкиназы
RU2016124119A (ru) Ингибиторы протеинкиназы