|
IL73534A
(en)
|
1983-11-18 |
1990-12-23 |
Riker Laboratories Inc |
1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
|
|
WO1995031223A1
(en)
|
1994-05-13 |
1995-11-23 |
Kuraray Co., Ltd. |
Medical polymer gel
|
|
US7662368B2
(en)
|
1999-07-16 |
2010-02-16 |
Institut Pasteur |
Method of inducing SHC phosphorylation of inducing the SHC/MAPK pathway by administering a peptide of IL-2
|
|
ATE500838T1
(de)
|
2000-09-08 |
2011-03-15 |
Amylin Pharmaceuticals Inc |
ßPSEUDOß-NATIVE CHEMISCHE LIGATION
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
ATE394412T1
(de)
|
2001-06-21 |
2008-05-15 |
Clontech Lab Inc |
Wasserlösliche polymere zusammensetzungen mit affinität für metallionen und verfahren zu deren anwendung
|
|
WO2003084571A1
(en)
|
2002-04-08 |
2003-10-16 |
Denki Kagaku Kogyo Kabushiki Kaisha |
Therapeutic composition for bone infectious disease
|
|
US7445894B2
(en)
|
2002-05-03 |
2008-11-04 |
Molecular Probes, Inc. |
Compositions and methods for detection and isolation of phosphorylated molecules
|
|
KR101145506B1
(ko)
|
2003-05-20 |
2012-05-15 |
이뮤노젠 아이엔씨 |
새로운 메이탠시노이드를 포함하는 개선된 세포독성체
|
|
EP1942950A2
(en)
|
2005-11-01 |
2008-07-16 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Biodegradable composite for internal local radiotherapy
|
|
US7919079B2
(en)
|
2006-03-31 |
2011-04-05 |
Biosante Pharmaceuticals, Inc. |
Cancer immunotherapy compositions and methods of use
|
|
JPWO2007119815A1
(ja)
|
2006-04-14 |
2009-08-27 |
協和発酵キリン株式会社 |
Toll様受容体9作動薬
|
|
EP1867638A1
(de)
|
2006-06-16 |
2007-12-19 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Verfahren zur kovalenten Verknüpfung zweier Moleküle mittels Diels-Alder-Reaktion mit inversem Elektronenbedarf
|
|
US8398956B2
(en)
|
2007-01-11 |
2013-03-19 |
Immunomedics, Inc. |
In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
|
|
US8236949B2
(en)
|
2007-07-17 |
2012-08-07 |
University Of Delaware |
Tetrazine-based bio-orthogonal coupling reagents and methods
|
|
ES2539353T3
(es)
|
2007-08-01 |
2015-06-30 |
Idera Pharmaceuticals, Inc. |
Nuevos agonistas sintéticos de TLR9
|
|
JP2011503111A
(ja)
|
2007-11-12 |
2011-01-27 |
バイパー サイエンシズ,インコーポレイティド |
Parp阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療
|
|
WO2011127149A1
(en)
|
2010-04-06 |
2011-10-13 |
University Of Utah Research Foundation |
Controlled release combination biomaterials
|
|
US8574629B2
(en)
|
2008-08-01 |
2013-11-05 |
Anteis S.A. |
Injectable hydrogel with an enhanced remanence and with an enhanced ability to create volume
|
|
WO2010051530A2
(en)
|
2008-10-31 |
2010-05-06 |
The General Hospital Corporation |
Compositions and methods for delivering a substance to a biological target
|
|
CN102215820A
(zh)
|
2008-11-17 |
2011-10-12 |
安龙制药公司 |
用于核酸输送系统的可释放融合脂质
|
|
RU2011135993A
(ru)
|
2009-01-30 |
2013-03-10 |
Идера Фармасьютикалз, Инк. |
Новые синтетические агонисты tlr9
|
|
BRPI1006246A2
(pt)
|
2009-04-16 |
2020-02-04 |
Koninl Philips Electronics Nv |
"kit para imagem médica marcada e/ou terapias, sonda efetora e método"
|
|
EP2360167A1
(en)
|
2010-02-03 |
2011-08-24 |
Deutsches Krebsforschungszentrum |
Post-synthetic modification of nucleic acids by inverse Diels-Alder reaction
|
|
WO2012012612A2
(en)
|
2010-07-23 |
2012-01-26 |
University Of Delaware |
Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes
|
|
RU2013121799A
(ru)
|
2010-10-14 |
2014-11-20 |
Конинклейке Филипс Электроникс Н.В. |
Набор для претаргетинга, способ и агенты, применяемые в нем
|
|
WO2012074840A2
(en)
|
2010-11-22 |
2012-06-07 |
The General Hospital Corporation |
Compositions and methods for in vivo imaging
|
|
EP2654796A1
(en)
|
2010-12-21 |
2013-10-30 |
Koninklijke Philips N.V. |
Agents for clearing biomolecules from circulation
|
|
EP2522369A1
(en)
|
2011-05-09 |
2012-11-14 |
Koninklijke Philips Electronics N.V. |
Pretargeting kit, method and agents used therein
|
|
EP2709666B1
(en)
|
2011-05-16 |
2021-07-14 |
Koninklijke Philips N.V. |
Bio-orthogonal drug activation
|
|
WO2012165462A1
(ja)
|
2011-05-31 |
2012-12-06 |
国立大学法人 東京大学 |
ハイドロゲル及びその製造方法
|
|
ES2393602B1
(es)
|
2011-06-09 |
2013-10-02 |
Universidad Complutense De Madrid |
Materiales biocerámicos para el tratamiento de la osteomielitis.
|
|
WO2013115885A2
(en)
|
2011-11-22 |
2013-08-08 |
The Regents Of The University Of Michigan |
Synthesizing functionalized dendrimers within biological settings
|
|
CA2865578C
(en)
|
2012-02-27 |
2023-01-17 |
Amunix Operating Inc. |
Xten conjugate compositions and methods of making same
|
|
US9206271B2
(en)
|
2012-03-25 |
2015-12-08 |
Wisconsin Alumni Research Foundation |
Fully backbone degradable and functionalizable polymers derived from the ring-opening metathesis polymerization (ROMP)
|
|
WO2013187954A1
(en)
|
2012-06-12 |
2013-12-19 |
The General Hospital Corporation |
Magnetic labeling of bacteria
|
|
WO2014065860A1
(en)
|
2012-10-24 |
2014-05-01 |
The General Hospital Corporation |
Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
|
|
EP2922574B1
(en)
|
2012-11-22 |
2023-05-17 |
Tagworks Pharmaceuticals B.V. |
Chemically cleavable group
|
|
WO2014081300A1
(en)
|
2012-11-22 |
2014-05-30 |
Tagworks Pharmaceuticals B.V. |
Channel protein activatable liposomes
|
|
WO2014081299A1
(en)
|
2012-11-22 |
2014-05-30 |
Tagworks Pharmaceuticals B.V. |
Activatable liposomes
|
|
WO2014081301A1
(en)
|
2012-11-22 |
2014-05-30 |
Tagworks Pharmaceuticals B.V. |
Bio-orthogonal drug activation
|
|
EA201590396A1
(ru)
|
2012-12-13 |
2015-12-30 |
Адуро Биотек, Инк. |
Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения
|
|
WO2014117001A1
(en)
|
2013-01-25 |
2014-07-31 |
Memorial Sloan-Kettering Cancer Center |
Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides
|
|
WO2014138186A1
(en)
|
2013-03-05 |
2014-09-12 |
The Johns Hopkins University |
Bioorthogonal two-component delivery systems for enhanced internalization of nanotherapeutics
|
|
KR102210895B1
(ko)
|
2013-03-08 |
2021-02-02 |
폴리액티바 피티와이 리미티드 |
생리활성 물질의 전달을 위한 폴리머 결합체
|
|
ME03586B
(me)
|
2013-05-18 |
2020-07-20 |
Univ California |
Sastavi i metode za aktiviranje signaliziranja koje je zavisno od .,stimulatora gena za interferon"
|
|
WO2014189806A1
(en)
|
2013-05-18 |
2014-11-27 |
Aduro Biotech, Inc. |
Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling
|
|
JP6600302B2
(ja)
|
2013-06-12 |
2019-10-30 |
ザ ジェネラル ホスピタル コーポレイション |
標的分子のマルチプレックス検出のための方法、キット、およびシステム、ならびにそれらの使用
|
|
WO2014205126A1
(en)
|
2013-06-19 |
2014-12-24 |
The Regents Of The University Of California |
Chemical structures for localized delivery of therapeutic agents
|
|
US10046002B2
(en)
|
2013-08-02 |
2018-08-14 |
Syntrix Biosystems Inc. |
Method for treating cancer using chemokine antagonists
|
|
EP3071209A4
(en)
|
2013-11-19 |
2017-08-16 |
The University of Chicago |
Use of sting agonist as cancer treatment
|
|
AU2015210750B2
(en)
|
2014-01-31 |
2020-08-20 |
Children's Medical Center Corporation |
Antibody molecules to TIM-3 and uses thereof
|
|
WO2015117235A1
(en)
|
2014-02-10 |
2015-08-13 |
Mcmaster University |
Targeted molecular imaging contrast agents
|
|
WO2015138920A1
(en)
|
2014-03-14 |
2015-09-17 |
Novartis Ag |
Antibody molecules to lag-3 and uses thereof
|
|
CN106659796B
(zh)
|
2014-03-14 |
2021-04-30 |
加利福尼亚大学董事会 |
Tco缀合物和治疗剂递送方法
|
|
ES2871029T3
(es)
|
2014-04-04 |
2021-10-28 |
Harvard College |
Dispositivos de liberación de fármacos recargables y procedimientos de uso de los mismos
|
|
ES2951908T3
(es)
|
2014-04-04 |
2023-10-25 |
Harvard College |
Hidrogeles reticulados por química clic y métodos de uso
|
|
WO2015185565A1
(en)
|
2014-06-04 |
2015-12-10 |
Glaxosmithkline Intellectual Property Development Limited |
Cyclic di-nucleotides as modulators of sting
|
|
WO2016014799A1
(en)
|
2014-07-23 |
2016-01-28 |
University Of Iowa Research Foundation |
Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy
|
|
GB201501462D0
(en)
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
JO3746B1
(ar)
|
2015-03-10 |
2021-01-31 |
Aduro Biotech Inc |
تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون"
|
|
AU2016270782B2
(en)
|
2015-05-29 |
2021-08-12 |
Dynavax Technologies Corporation |
Intrapulmonary administration of polynucleotide toll-like receptor 9 agonists for treating cancer of the lung
|
|
IL256652B2
(en)
|
2015-06-29 |
2026-03-01 |
Verastem Inc |
Dapatinib in combination with an anti-PD1 antibody, anti-PDL1 antibody, or anti-PD1 ligand for use in the treatment of cancer
|
|
MX2018001814A
(es)
|
2015-08-13 |
2018-05-07 |
Merck Sharp & Dohme |
Compuestos dinucleotidos ciclicos como agonistas del estimulador de genes de interferon.
|
|
JP6823067B2
(ja)
|
2015-09-10 |
2021-01-27 |
タンボ・インコーポレイテッド |
生体直交型組成物
|
|
UY36969A
(es)
|
2015-10-28 |
2017-05-31 |
Novartis Ag |
Composiciones y métodos para activar la señalización dependiente del estimulador del gen de interferon
|
|
JP6411676B2
(ja)
|
2015-12-03 |
2018-10-24 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
Stingの調節因子としての環状プリンジヌクレオチド
|
|
HUE073018T2
(hu)
|
2016-01-11 |
2026-01-28 |
Innate Tumor Immunity Inc |
Ciklikus dinukleotidok állapotok kezelésére, amelyek STING-aktivitással kapcsolatosak, mint például rák
|
|
KR102775461B1
(ko)
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
EP3448260A4
(en)
*
|
2016-04-27 |
2019-10-09 |
Immunomedics, Inc. |
EFFICACY OF ANTI-TROP-2 SN-38 ANTIBODY CONJUGATES FOR THE THERAPY OF REZIDIVATED / REFRACTORY TUMORS AGAINST CHECKPOINT INHIBITORS
|
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
KR102569881B1
(ko)
|
2016-07-06 |
2023-08-22 |
에프-스타 테라퓨틱스 인코포레이티드 |
질병 치료용 화합물, 조성물 및 방법
|
|
TW201803886A
(zh)
|
2016-07-06 |
2018-02-01 |
史貝羅威生物科學有限公司 |
化合物、組合物及用於治療疾病之方法
|
|
EP3484504A4
(en)
|
2016-07-15 |
2020-07-29 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATMENT OF DISEASE
|
|
WO2018013887A1
(en)
|
2016-07-15 |
2018-01-18 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
US10414747B2
(en)
|
2016-10-04 |
2019-09-17 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene compounds as sting agonists
|
|
JOP20170188A1
(ar)
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
PT3512861T
(pt)
|
2016-12-01 |
2021-04-29 |
Takeda Pharmaceuticals Co |
Dinucleotídeos cíclicos
|
|
AU2017378783A1
(en)
|
2016-12-20 |
2019-07-04 |
Merck Sharp & Dohme Corp. |
Cyclic dinucleotide sting agonists for cancer treatment
|
|
JP7213188B2
(ja)
|
2017-01-27 |
2023-01-26 |
ヤンセン バイオテツク,インコーポレーテツド |
Stingアゴニストとしての環状ジヌクレオチド
|
|
US11492367B2
(en)
|
2017-01-27 |
2022-11-08 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
JOP20190218A1
(ar)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
مركبات ثنائية النيوكليوتيدات حلقية معدلة
|
|
ES2983582T3
(es)
|
2017-04-07 |
2024-10-23 |
Tambo Inc |
Composiciones bioortogonales
|
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
|
WO2018208667A1
(en)
|
2017-05-12 |
2018-11-15 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
|
JP2020524717A
(ja)
|
2017-06-22 |
2020-08-20 |
キュラデブ・ファーマ・リミテッドCuradev Pharma Limited |
ヒトstingの小分子調節因子
|
|
JP2020524718A
(ja)
|
2017-06-22 |
2020-08-20 |
キュラデブ・ファーマ・リミテッドCuradev Pharma Limited |
ヒトstingの複素環式小分子調節因子
|
|
CA3067257A1
(en)
|
2017-06-22 |
2018-12-27 |
Curadev Pharma Limited |
Small molecule modulators of human sting
|
|
JP2020530838A
(ja)
|
2017-08-04 |
2020-10-29 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
がん治療のためのベンゾ[b]チオフェンSTINGアゴニスト
|
|
US11638716B2
(en)
|
2017-08-31 |
2023-05-02 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
|
WO2019051489A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
WO2019051488A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE
|
|
AR114990A1
(es)
|
2017-11-02 |
2020-11-18 |
Alios Biopharma Inc |
Constructos de oligonucleótidos y usos de los mismos
|
|
MX2020004858A
(es)
|
2017-11-10 |
2020-10-01 |
Takeda Pharmaceuticals Co |
Compuestos moduladores de sting y metodos de elaboracion y uso.
|
|
CN111801419A
(zh)
|
2017-12-15 |
2020-10-20 |
拜耳动物保健有限责任公司 |
免疫刺激性寡核苷酸
|
|
EP3724205B1
(en)
|
2017-12-15 |
2022-06-22 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
WO2019123338A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'2' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
EP3727401A4
(en)
|
2017-12-20 |
2022-04-06 |
Merck Sharp & Dohme Corp. |
CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
|
|
JP7098748B2
(ja)
|
2017-12-20 |
2022-07-11 |
インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. |
Stingアダプタータンパク質を活性化するホスホン酸結合を有する2’3’環状ジヌクレオチド
|
|
KR102492187B1
(ko)
|
2017-12-20 |
2023-01-27 |
인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. |
Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 3'3' 사이클릭 다이뉴클레오티드
|
|
CA3099421C
(en)
*
|
2018-05-04 |
2025-05-06 |
Tagworks Pharmaceuticals B.V. |
COMPOUNDS INCLUDING A BINDER TO INCREASE TRANSCYCLOOCTENE STABILITY
|
|
JP7622031B2
(ja)
*
|
2019-07-05 |
2025-01-27 |
タンボ・インコーポレイテッド |
トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
|
|
CN110496233B
(zh)
*
|
2019-09-05 |
2022-07-19 |
复旦大学附属中山医院 |
一种spect显像剂及其标记前体及其制备方法、组合物和用途
|