JP2023522202A5 - - Google Patents
Info
- Publication number
- JP2023522202A5 JP2023522202A5 JP2022562815A JP2022562815A JP2023522202A5 JP 2023522202 A5 JP2023522202 A5 JP 2023522202A5 JP 2022562815 A JP2022562815 A JP 2022562815A JP 2022562815 A JP2022562815 A JP 2022562815A JP 2023522202 A5 JP2023522202 A5 JP 2023522202A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently selected
- cycloalkyl
- alkylene
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025165118A JP2026021310A (ja) | 2020-04-16 | 2025-10-01 | 融合三環式ｋｒａｓ阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063011089P | 2020-04-16 | 2020-04-16 | |
| US63/011,089 | 2020-04-16 | ||
| US202163146899P | 2021-02-08 | 2021-02-08 | |
| US63/146,899 | 2021-02-08 | ||
| PCT/US2021/027513 WO2021211864A1 (en) | 2020-04-16 | 2021-04-15 | Fused tricyclic kras inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025165118A Division JP2026021310A (ja) | 2020-04-16 | 2025-10-01 | 融合三環式ｋｒａｓ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023522202A JP2023522202A (ja) | 2023-05-29 |
| JP2023522202A5 true JP2023522202A5 (https=) | 2025-06-13 |
| JP7753246B2 JP7753246B2 (ja) | 2025-10-14 |
Family
ID=75870725
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022562815A Active JP7753246B2 (ja) | 2020-04-16 | 2021-04-15 | 融合三環式ｋｒａｓ阻害剤 |
| JP2025165118A Pending JP2026021310A (ja) | 2020-04-16 | 2025-10-01 | 融合三環式ｋｒａｓ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025165118A Pending JP2026021310A (ja) | 2020-04-16 | 2025-10-01 | 融合三環式ｋｒａｓ阻害剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20210355121A1 (https=) |
| EP (1) | EP4135844A1 (https=) |
| JP (2) | JP7753246B2 (https=) |
| CN (3) | CN115702025B (https=) |
| AU (1) | AU2021254794A1 (https=) |
| BR (1) | BR112022020841A2 (https=) |
| CA (1) | CA3179692A1 (https=) |
| CL (2) | CL2022002828A1 (https=) |
| CO (1) | CO2022016377A2 (https=) |
| CR (1) | CR20220584A (https=) |
| EC (1) | ECSP22087539A (https=) |
| IL (1) | IL297165A (https=) |
| MX (1) | MX2022012780A (https=) |
| PE (1) | PE20230825A1 (https=) |
| PH (1) | PH12022552739A1 (https=) |
| TW (1) | TWI894260B (https=) |
| WO (1) | WO2021211864A1 (https=) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| JP2022500385A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| EP3849535A4 (en) | 2018-09-10 | 2022-06-29 | Mirati Therapeutics, Inc. | Combination therapies |
| EA202190749A1 (ru) | 2018-09-10 | 2021-07-09 | Мирати Терапьютикс, Инк. | Способы комбинированной терапии |
| EP3849537B1 (en) | 2018-09-10 | 2024-10-23 | Mirati Therapeutics, Inc. | Combination therapies |
| MX2021002804A (es) | 2018-12-05 | 2021-07-15 | Mirati Therapeutics Inc | Terapias de combinacion. |
| EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
| MX2022002465A (es) | 2019-08-29 | 2022-05-19 | Mirati Therapeutics Inc | Inhibidores de kras g12d. |
| WO2021061749A1 (en) | 2019-09-24 | 2021-04-01 | Mirati Therapeutics, Inc. | Combination therapies |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| PH12022551513A1 (en) | 2019-12-20 | 2023-04-24 | Mirati Therapeutics Inc | Sos1 inhibitors |
| WO2021150613A1 (en) | 2020-01-20 | 2021-07-29 | Incyte Corporation | Spiro compounds as inhibitors of kras |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
| EP4210833A4 (en) | 2020-09-11 | 2024-09-11 | Mirati Therapeutics, Inc. | CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR |
| JP2023544450A (ja) | 2020-09-23 | 2023-10-23 | エラスカ・インコーポレイテッド | 三環式ピリドン及びピリミドン |
| US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
| JP2023553492A (ja) | 2020-12-15 | 2023-12-21 | ミラティ セラピューティクス， インコーポレイテッド | アザキナゾリン汎ＫＲａｓ阻害剤 |
| EP4262803A4 (en) | 2020-12-16 | 2025-03-12 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-kras inhibitors |
| WO2022133345A1 (en) | 2020-12-18 | 2022-06-23 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| US12331063B2 (en) | 2021-04-29 | 2025-06-17 | Incyte Corporation | Hetero-bicyclic inhibitors of KRAS |
| KR20240017811A (ko) | 2021-05-05 | 2024-02-08 | 레볼루션 메디슨즈, 인크. | 암의 치료를 위한 ras 억제제 |
| TW202309052A (zh) | 2021-05-05 | 2023-03-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| MX2024000357A (es) | 2021-07-07 | 2024-02-12 | Incyte Corp | Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras). |
| WO2023287896A1 (en) | 2021-07-14 | 2023-01-19 | Incyte Corporation | Tricyclic compounds as inhibitors of kras |
| US12441742B2 (en) | 2021-08-31 | 2025-10-14 | Incyte Corporation | Naphthyridine compounds as inhibitors of KRAS |
| WO2023049697A1 (en) | 2021-09-21 | 2023-03-30 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of kras |
| CA3234375A1 (en) * | 2021-10-01 | 2023-04-06 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
| CA3235146A1 (en) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
| EP4416146A4 (en) * | 2021-10-15 | 2025-11-05 | Lomond Therapeutics Inc | 1H-PYRAZOLO[4,3-C]QUINOLINE SUBSTITUTES, THEIR PREPARATION PROCESSES AND THEIR USE |
| MX2024006113A (es) | 2021-11-22 | 2024-07-29 | Incyte Corp | Terapia de combinación que comprende un inhibidor del receptor del factor de crecimiento de fibroblastos (fgfr) y un inhibidor del sarcoma de rata de kirsten (kras). |
| CN119212994A (zh) | 2021-12-17 | 2024-12-27 | 建新公司 | 作为shp2抑制剂的吡唑并吡嗪化合物 |
| CN115317490A (zh) * | 2021-12-24 | 2022-11-11 | 南通大学附属医院 | 化合物bml-275在制备改善鼻咽癌预后的药物中的应用 |
| CN114394967B (zh) * | 2022-01-28 | 2023-12-15 | 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） | 一种2-吡唑苯胺与1,3-二羰基化合物合成吡唑并喹啉衍生物的方法 |
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| JP2025510572A (ja) | 2022-03-08 | 2025-04-15 | レボリューション メディシンズ インコーポレイテッド | 免疫不応性肺癌を治療するための方法 |
| WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| US20240101557A1 (en) * | 2022-07-11 | 2024-03-28 | Incyte Corporation | Fused tricyclic compounds as inhibitors of kras g12v mutants |
| AU2024241633A1 (en) | 2023-03-30 | 2025-11-06 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| AR132338A1 (es) | 2023-04-07 | 2025-06-18 | Revolution Medicines Inc | Inhibidores de ras |
| CR20250420A (es) | 2023-04-07 | 2025-11-20 | Revolution Medicines Inc | Inhibidores macrocíclicos de ras |
| CN121100123A (zh) | 2023-04-14 | 2025-12-09 | 锐新医药公司 | Ras抑制剂的结晶形式 |
| CN121464140A (zh) | 2023-04-14 | 2026-02-03 | 锐新医药公司 | Ras抑制剂的结晶形式、含有其的组合物及其使用方法 |
| CR20250500A (es) * | 2023-04-18 | 2026-01-12 | Incyte Corp | Inhibidores de kras de 2-azabiciclo [2.2.1] heptano |
| US20240390340A1 (en) * | 2023-04-18 | 2024-11-28 | Incyte Corporation | Pyrrolidine kras inhibitors |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| PE20252789A1 (es) | 2023-05-24 | 2025-12-22 | Kumquat Biosciences Inc | Compuestos heterociclicos y usos de estos |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| US20250109147A1 (en) | 2023-09-08 | 2025-04-03 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20250114339A1 (en) * | 2023-10-09 | 2025-04-10 | Incyte Corporation | Combination therapy comprising a kras g12d inhibitor and an egfr inhibitor |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| AU2024361909A1 (en) | 2023-10-20 | 2026-03-26 | Merck Sharp & Dohme Llc | Small molecule inhibitors of kras proteins |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
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-
2021
- 2021-04-15 AU AU2021254794A patent/AU2021254794A1/en active Pending
- 2021-04-15 BR BR112022020841A patent/BR112022020841A2/pt unknown
- 2021-04-15 PE PE2022002194A patent/PE20230825A1/es unknown
- 2021-04-15 JP JP2022562815A patent/JP7753246B2/ja active Active
- 2021-04-15 CA CA3179692A patent/CA3179692A1/en active Pending
- 2021-04-15 WO PCT/US2021/027513 patent/WO2021211864A1/en not_active Ceased
- 2021-04-15 MX MX2022012780A patent/MX2022012780A/es unknown
- 2021-04-15 CN CN202180042226.6A patent/CN115702025B/zh active Active
- 2021-04-15 PH PH1/2022/552739A patent/PH12022552739A1/en unknown
- 2021-04-15 CN CN202511243313.4A patent/CN121270549A/zh active Pending
- 2021-04-15 CR CR20220584A patent/CR20220584A/es unknown
- 2021-04-15 IL IL297165A patent/IL297165A/en unknown
- 2021-04-15 EP EP21724424.3A patent/EP4135844A1/en active Pending
- 2021-04-15 US US17/231,547 patent/US20210355121A1/en not_active Abandoned
- 2021-04-15 CN CN202511243319.1A patent/CN121270550A/zh active Pending
- 2021-04-16 TW TW110113769A patent/TWI894260B/zh active
-
2022
- 2022-10-13 CL CL2022002828A patent/CL2022002828A1/es unknown
- 2022-11-15 EC ECSENADI202287539A patent/ECSP22087539A/es unknown
- 2022-11-15 CO CONC2022/0016377A patent/CO2022016377A2/es unknown
-
2023
- 2023-07-18 CL CL2023002090A patent/CL2023002090A1/es unknown
-
2025
- 2025-10-01 JP JP2025165118A patent/JP2026021310A/ja active Pending
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