JP2023518970A5 - - Google Patents

Info

Publication number
JP2023518970A5
JP2023518970A5 JP2022558064A JP2022558064A JP2023518970A5 JP 2023518970 A5 JP2023518970 A5 JP 2023518970A5 JP 2022558064 A JP2022558064 A JP 2022558064A JP 2022558064 A JP2022558064 A JP 2022558064A JP 2023518970 A5 JP2023518970 A5 JP 2023518970A5
Authority
JP
Japan
Prior art keywords
formula
aryl
alkyl
group
allyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022558064A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023518970A (ja
JP7837560B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/024425 external-priority patent/WO2021195533A2/en
Publication of JP2023518970A publication Critical patent/JP2023518970A/ja
Publication of JP2023518970A5 publication Critical patent/JP2023518970A5/ja
Application granted granted Critical
Publication of JP7837560B2 publication Critical patent/JP7837560B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022558064A 2020-03-26 2021-03-26 安定性の向上を有する修飾オリゴヌクレオチドの合成 Active JP7837560B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063000328P 2020-03-26 2020-03-26
US63/000,328 2020-03-26
PCT/US2021/024425 WO2021195533A2 (en) 2020-03-26 2021-03-26 Synthesis of modified oligonucleotides with increased stability

Publications (3)

Publication Number Publication Date
JP2023518970A JP2023518970A (ja) 2023-05-09
JP2023518970A5 true JP2023518970A5 (https=) 2024-04-08
JP7837560B2 JP7837560B2 (ja) 2026-03-31

Family

ID=77892398

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022558064A Active JP7837560B2 (ja) 2020-03-26 2021-03-26 安定性の向上を有する修飾オリゴヌクレオチドの合成

Country Status (7)

Country Link
US (2) US12146136B2 (https=)
EP (1) EP4126070A4 (https=)
JP (1) JP7837560B2 (https=)
CN (2) CN115666659B (https=)
AU (1) AU2021244600A1 (https=)
CA (1) CA3172168A1 (https=)
WO (1) WO2021195533A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160319278A1 (en) 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ 2テイル自己デリバリー型siRNAおよび関連方法
EP3781677A4 (en) 2018-04-16 2022-01-19 University of Massachusetts COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITTING
US11279930B2 (en) 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
US11820985B2 (en) 2019-03-26 2023-11-21 University Of Massachusetts Modified oligonucleotides with increased stability
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
JP7837560B2 (ja) 2020-03-26 2026-03-31 ユニバーシティー オブ マサチューセッツ 安定性の向上を有する修飾オリゴヌクレオチドの合成
WO2021242883A1 (en) * 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
EP4314296A2 (en) 2021-03-29 2024-02-07 Alnylam Pharmaceuticals, Inc. Huntingtin (htt) irna agent compositions and methods of use thereof
CN117677699A (zh) 2021-06-23 2024-03-08 马萨诸塞大学 用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
US20250066780A1 (en) * 2023-06-28 2025-02-27 University Of Massachusetts Oligonucleotides with internucleotide linkage modifications for kidney targeting
WO2025072699A1 (en) 2023-09-27 2025-04-03 Judo Bio, Inc. Aminoglycosides for delivery of agents to the kidney
WO2025072713A1 (en) 2023-09-27 2025-04-03 Judo Bio, Inc. Polymyxins for delivery of agents to the kidney
WO2025072672A2 (en) 2023-09-27 2025-04-03 Judo Bio, Inc. Slc6a19-targeting modulatory nucleic acid agents
WO2025264952A2 (en) 2024-06-21 2025-12-26 Eli Lilly And Company Novel rna therapeutics and uses thereof
WO2026006109A2 (en) 2024-06-24 2026-01-02 Eli Lilly And Company Novel rna therapeutics and uses thereof
WO2026006107A1 (en) 2024-06-24 2026-01-02 Eli Lilly And Company Novel oligonucleotides bearing a "2-propyl" internucleoside linkage

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
ES2113371T3 (es) 1989-11-16 1998-05-01 Univ Duke Transformacion de celulas epidermicas de tejidos animales con la ayuda de particulas.
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5672697A (en) 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
JPH0641183A (ja) 1992-07-23 1994-02-15 Mitsubishi Kasei Corp オリゴヌクレオチド単分子膜
US5858988A (en) 1993-02-24 1999-01-12 Wang; Jui H. Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
WO1994022890A1 (en) 1993-03-31 1994-10-13 Sterling Winthop Inc. Novel 5'-substituted nucleosides and oligomers produced therefrom
TW360548B (en) 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
WO1996003500A1 (en) 1994-07-26 1996-02-08 Ltt Institute Co., Ltd. Sustance with antiviral activity
WO1996033761A1 (en) 1995-04-28 1996-10-31 Medtronic, Inc. Intraparenchymal infusion catheter system
US6025335A (en) 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
US5684143A (en) 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US5735814A (en) 1996-04-30 1998-04-07 Medtronic, Inc. Techniques of treating neurodegenerative disorders by brain infusion
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6177403B1 (en) 1996-10-21 2001-01-23 The Trustees Of The University Of Pennsylvania Compositions, methods, and apparatus for delivery of a macromolecular assembly to an extravascular tissue of an animal
US6042820A (en) 1996-12-20 2000-03-28 Connaught Laboratories Limited Biodegradable copolymer containing α-hydroxy acid and α-amino acid units
US6472375B1 (en) 1998-04-16 2002-10-29 John Wayne Cancer Institute DNA vaccine and methods for its use
US6242589B1 (en) 1998-07-14 2001-06-05 Isis Pharmaceuticals, Inc. Phosphorothioate oligonucleotides having modified internucleoside linkages
EP2447370B1 (en) 2001-09-28 2018-07-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. MicroRNA molecules
US20100240730A1 (en) 2002-02-20 2010-09-23 Merck Sharp And Dohme Corp. RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
US7858367B2 (en) 2002-04-30 2010-12-28 Duke University Viral vectors and methods for producing and using the same
AU2003285071A1 (en) 2002-10-30 2004-06-07 Nikolaos Avlonitis Antiprotozoal ring-substituted phospholipids
US7750144B2 (en) 2003-06-02 2010-07-06 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of RNA silencing
EP1633890B2 (en) 2003-06-02 2020-11-18 University of Massachusetts METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi
PT1633767T (pt) 2003-06-02 2019-02-27 Univ Massachusetts Métodos e composições para controlar a eficácia do silenciamento de arn
DE10326302A1 (de) 2003-06-11 2004-12-30 Gnothis Holding Sa Bi-Fluorophor-markierte Sonden zum Nachweis von Nukleinsäuren
US20050176045A1 (en) 2004-02-06 2005-08-11 Dharmacon, Inc. SNP discriminatory siRNA
WO2005077333A2 (en) 2004-02-10 2005-08-25 University Of Florida Research Foundation, Inc. Gel-based delivery of recombinant adeno-associated virus vectors
EP1789553B1 (en) 2004-06-30 2014-03-26 Alnylam Pharmaceuticals Inc. Oligonucleotides comprising a non-phosphate backbone linkage
JP5136766B2 (ja) 2004-12-15 2013-02-06 ユニバーシティ オブ ノース カロライナ アット チャペル ヒル キメラベクター
US9217155B2 (en) 2008-05-28 2015-12-22 University Of Massachusetts Isolation of novel AAV'S and uses thereof
EP2342340A1 (en) 2008-09-22 2011-07-13 Rxi Pharmaceuticals Corporation Rna interference in skin indications
US8309356B2 (en) 2009-04-01 2012-11-13 Yale University Pseudocomplementary oligonucleotides for targeted gene therapy
WO2010118263A1 (en) 2009-04-08 2010-10-14 University Of Massachusetts Single-nucleotide polymorphism (snp) targeting therapies for the treatment of huntington's disease
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
EP2470656B1 (en) 2009-08-27 2015-05-06 Idera Pharmaceuticals, Inc. Composition for inhibiting gene expression and uses thereof
US8957040B2 (en) 2010-02-08 2015-02-17 Isis Pharmaceuticals, Inc. Selective reduction of allelic variants
WO2011125943A1 (ja) 2010-04-01 2011-10-13 日本新薬株式会社 修飾オリゴヌクレオチド
CN103562205A (zh) 2010-12-16 2014-02-05 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
CA2822059A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
GB201105137D0 (en) 2011-03-28 2011-05-11 Isis Innovation Therapeutic molecules for use in the suppression of Parkinson's disease
KR102104125B1 (ko) 2011-04-21 2020-05-29 재단법인 한국파스퇴르연구소 소염 화합물
EP3007705A4 (en) 2013-06-12 2017-02-15 Oncoimmunin, Inc. Systemic in vivo delivery of oligonucleotides
WO2015113004A2 (en) 2014-01-27 2015-07-30 The Board Of Trustee Of The Leland Stanford Junior University Oligonucleotides and methods for treatment of cardiomyopathy using rna interference
US20170051286A1 (en) 2014-05-01 2017-02-23 Larry J. Smith METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
PL3277814T3 (pl) 2015-04-03 2020-11-30 University Of Massachusetts Związki oligonukleotydowe ukierunkowane na mrna huntingtyny
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
CN110352244B (zh) 2016-09-01 2023-03-21 ProQR治疗上市公司Ⅱ 化学修饰的编辑rna的单链寡核苷酸
JP2020522510A (ja) 2017-06-02 2020-07-30 ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. オリゴヌクレオチド組成物及びその使用方法
WO2020033899A1 (en) 2018-08-10 2020-02-13 University Of Massachusetts Modified oligonucleotides targeting snps
US11279930B2 (en) * 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
US11820985B2 (en) 2019-03-26 2023-11-21 University Of Massachusetts Modified oligonucleotides with increased stability
ES3014076T3 (en) 2020-03-26 2025-04-16 Nutrivert Inc Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity
JP7837560B2 (ja) 2020-03-26 2026-03-31 ユニバーシティー オブ マサチューセッツ 安定性の向上を有する修飾オリゴヌクレオチドの合成

Similar Documents

Publication Publication Date Title
JP2023518970A5 (https=)
JP6284977B2 (ja) 2’−o−修飾rna
JP2552048B2 (ja) ヌクレオチド鎖合成用試薬
EP1510523A1 (en) Precurors for two-step polynucleotide synthesis
JP2024527542A5 (https=)
RU2019141655A (ru) Композиции и способы химического расщепления и снятия защиты для связанных с поверхностью олигонуклеотидов
EP1512691A1 (en) Protecting groups for two-step polynucleotide synthesis
JP5184621B2 (ja) α−リン酸擬似体を有するヌクレオチド
RU96122244A (ru) Способ диастереоселективного синтеза аналогов нуклеозидов
JP2006306873A (ja) ポリヌクレオチドを合成するための方法及び組成物
EP1510522A1 (en) Method of polynucleotide synthesis using modified support
JP2011506265A5 (https=)
JP2023546369A5 (https=)
JP2008138005A (ja) 新規な保護基及びオリゴヌクレオチド合成のための改良方法における該新規な保護基の使用
JP2017518966A (ja) リン保護基ならびにそれらの調製方法および使用
EP0607337A1 (fr) Procede de synthese d'acide ribonucleique (arn) utilisant un nouveau reactif de deprotection.
US20230148152A1 (en) Method of synthesizing single-stranded nucleotide sequence, blocked nucleoside triphosphates and related methods
JP2023517735A5 (https=)
JP7759323B2 (ja) 核酸オリゴマーの製造方法
CN1900103A (zh) 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法
JPWO2021095875A5 (https=)
CA2371890A1 (fr) Procede de fabrication de morpholino-nucleotides, et leur utilisation pour l'analyse et le marquage de sequences d'acides nucleiques
BRPI0609351A2 (pt) método para preparar um oligonucleotìdeo, e, uso de cetonas
JP2023503985A5 (https=)
JP2024530774A5 (https=)