|
US20040110938A1
(en)
|
2000-02-24 |
2004-06-10 |
Parekh Rajesh Bhikhu |
Proteins, genes and their use for diagnosis and treatment of schizophrenia
|
|
AU2002236499A8
(en)
|
2000-11-30 |
2009-12-03 |
Uab Research Foundation |
Receptor-mediated uptake of peptides that bind the human transferrin receptor
|
|
ES2411007T3
(es)
|
2001-10-10 |
2013-07-04 |
Novo Nordisk A/S |
Remodelación y glicoconjugación de péptidos
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US20050123962A1
(en)
|
2003-10-28 |
2005-06-09 |
Agy Therapeutics, Inc. |
Regulated nucleic acids in pathogenesis of alzheimer's disease
|
|
EP1697520A2
(en)
|
2003-12-22 |
2006-09-06 |
Xencor, Inc. |
Fc polypeptides with novel fc ligand binding sites
|
|
EP1699826B1
(en)
|
2005-01-05 |
2009-03-11 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
|
|
US8486635B2
(en)
|
2006-05-30 |
2013-07-16 |
Mayo Foundation For Medical Education And Research |
Detecting and treating dementia
|
|
EP2687223B2
(en)
|
2006-05-30 |
2024-11-20 |
Mayo Foundation For Medical Education And Research |
Detecting and treating dementia
|
|
HUE031156T2
(en)
|
2006-06-07 |
2017-06-28 |
Genzyme Corp |
Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
|
|
WO2008094687A2
(en)
|
2007-01-31 |
2008-08-07 |
New York University |
Gep, a novel chondrogenic growth factor and target in cartilage disorders
|
|
DE102007033359B4
(de)
|
2007-07-16 |
2010-12-02 |
Johann Wolfgang Goethe-Universität Frankfurt am Main |
Verwendung eines Granulins oder einer Granulin-ähnlichen Verbindung zur Therapie oder Prophylaxe von chronischen Schmerzen
|
|
WO2009089635A1
(en)
|
2008-01-16 |
2009-07-23 |
Neurodyn, Inc. |
Treating neurodegenerative diseases with progranulin (pgrn)
|
|
US20120039865A1
(en)
|
2008-08-19 |
2012-02-16 |
Yale University |
Identification of sortilin as a neuronal receptor for the frontotemporal dementia protein, progranulin
|
|
KR20100054711A
(ko)
*
|
2008-11-14 |
2010-05-25 |
메디포스트(주) |
간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물
|
|
US8362218B2
(en)
|
2009-04-17 |
2013-01-29 |
New York University School Of Medicine |
Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof
|
|
JP6312436B2
(ja)
|
2010-11-16 |
2018-04-18 |
ニューロダイン ライフ サイエンシズ インコーポレイテッドNeurodyn Life Sciences Inc. |
ネプリライシンの発現および活性を増大させるための方法および医薬組成物
|
|
CA2818173C
(en)
|
2010-11-30 |
2022-05-03 |
Genentech, Inc. |
Low affinity blood brain barrier receptor antibodies and uses therefor
|
|
RU2018108836A
(ru)
|
2011-02-04 |
2019-03-14 |
Дженентек, Инк. |
ВАРИАНТЫ Fc И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
|
|
US10689447B2
(en)
|
2011-02-04 |
2020-06-23 |
Genentech, Inc. |
Fc variants and methods for their production
|
|
BR112013023918A2
(pt)
|
2011-03-25 |
2016-12-13 |
Glenmark Pharmaceuticals Sa |
imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para produzir uma imunoglobulina hetero-dimérica ou fragmento hetero-dimérico da mesma, método para construir uma interface proteína-proteína de um domínio de uma proteína de múltiplos domínios e uso de um domínio doador de um primeiro e de um segundo membro de uma super-família de imunoglobulina de ocorrência natural
|
|
EA201892619A1
(ru)
|
2011-04-29 |
2019-04-30 |
Роше Гликарт Аг |
Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
|
|
JP2015502397A
(ja)
|
2011-12-23 |
2015-01-22 |
ファイザー・インク |
部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
|
|
CA2871468C
(en)
|
2012-04-23 |
2021-09-21 |
Nrl Pharma, Inc. |
Lactoferrin fusion protein and method for preparation thereof
|
|
HUE045144T2
(hu)
|
2012-08-29 |
2019-12-30 |
Hoffmann La Roche |
Véragygát-shuttle
|
|
JP6385357B2
(ja)
|
2012-11-27 |
2018-09-05 |
アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションAjou University Industry−Academic Cooperation Foundation |
抗体重鎖不変部位の異種二量体、高効率の形成を誘導するch3ドメイン変異体対、その作製方法および用途
|
|
WO2014089209A2
(en)
|
2012-12-04 |
2014-06-12 |
Abbvie, Inc. |
Blood-brain barrier (bbb) penetrating dual specific binding proteins
|
|
WO2014185964A1
(en)
|
2013-05-14 |
2014-11-20 |
California Institute Of Technology |
Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier
|
|
EP3594240B1
(en)
|
2013-05-20 |
2023-12-06 |
F. Hoffmann-La Roche AG |
Anti-transferrin receptor antibodies and methods of use
|
|
ME03675B
(me)
|
2013-07-05 |
2020-10-20 |
Genmab As |
Humanizovana ili himerna anтi-cd3 antiтela
|
|
US9862752B2
(en)
|
2013-07-31 |
2018-01-09 |
Amgen Inc. |
Growth differentiation factor 15 (GDF-15) constructs
|
|
EP3035969B1
(en)
|
2013-08-19 |
2022-08-03 |
S.M. Discovery Holdings Inc. |
Peptidic nanodelivery composition targeting two receptors
|
|
US10357542B2
(en)
|
2014-02-04 |
2019-07-23 |
New York University |
Progranulin (PGRN) and its derivatives for diagnosis and treatment of lysosomal storage diseases
|
|
CN105273087A
(zh)
*
|
2014-07-14 |
2016-01-27 |
复旦大学 |
NGF-Fc融合蛋白及其制备方法
|
|
EP3218411B1
(en)
|
2014-11-14 |
2022-01-12 |
Ossianix, Inc. |
Variable new antigen receptors (vnars) directed against transferrin receptor (tfr) and their use
|
|
WO2016081640A1
(en)
|
2014-11-19 |
2016-05-26 |
Genentech, Inc. |
Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
|
|
US10508151B2
(en)
|
2014-11-19 |
2019-12-17 |
Genentech, Inc. |
Anti-transferrin receptor antibodies and methods of use
|
|
DK3221357T3
(da)
|
2014-11-20 |
2020-08-10 |
Hoffmann La Roche |
Fælles letkæder og fremgangsmåder til anvendelse
|
|
CN107531788B
(zh)
|
2015-06-24 |
2022-06-21 |
豪夫迈·罗氏有限公司 |
对her2和血脑屏障受体特异性的三特异性抗体及使用方法
|
|
EA039366B1
(ru)
|
2015-06-24 |
2022-01-19 |
Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. |
Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер
|
|
HUE057952T2
(hu)
|
2015-06-24 |
2022-06-28 |
Hoffmann La Roche |
Anti-transzferrin receptor antitestek testreszabott affinitással
|
|
GB201512215D0
(en)
*
|
2015-07-13 |
2015-08-19 |
Lundbeck & Co As H |
Agents,uses and methods
|
|
WO2017024137A1
(en)
|
2015-08-04 |
2017-02-09 |
New York University |
Progranulin (pgrn) fragments and derivatives for treatment or alleviation of lysosomal storage diseases
|
|
CA2998174A1
(en)
|
2015-09-15 |
2017-03-23 |
Amgen Inc. |
Tetravalent bispecific and tetraspecific antigen binding proteins and uses thereof
|
|
AR106189A1
(es)
|
2015-10-02 |
2017-12-20 |
Hoffmann La Roche |
ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
|
|
US20210284701A1
(en)
*
|
2016-07-14 |
2021-09-16 |
Emory University |
Granulin Compositions and Uses Related Thereto
|
|
KR102497564B1
(ko)
|
2016-12-26 |
2023-02-07 |
제이씨알 파마 가부시키가이샤 |
혈액뇌관문을 통과하는 신규한 항인간 트랜스페린 수용체 항체
|
|
CN110506055A
(zh)
|
2017-02-17 |
2019-11-26 |
戴纳立制药公司 |
工程改造的转铁蛋白受体结合多肽
|
|
SG11201907422RA
(en)
|
2017-02-17 |
2019-09-27 |
Denali Therapeutics Inc |
Anti-tau antibodies and methods of use thereof
|
|
US10457717B2
(en)
|
2017-02-17 |
2019-10-29 |
Denali Therapeutics Inc. |
Engineered polypeptides
|
|
EP3665194A4
(en)
|
2017-08-10 |
2021-07-07 |
Denali Therapeutics Inc. |
AFFINITY BASED METHODS OF USING TRANSFERRIN RECEPTOR BINDING PROTEINS
|
|
CR20200129A
(es)
|
2017-10-02 |
2020-08-22 |
Denali Therapeutics Inc |
Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas
|
|
WO2019094608A1
(en)
|
2017-11-08 |
2019-05-16 |
Denali Therapeutics Inc. |
Anti-bace1 antibodies and methods of use thereof
|
|
TW201934573A
(zh)
|
2018-01-10 |
2019-09-01 |
美商戴納立製藥公司 |
轉鐵蛋白受體結合性多肽及其用途
|
|
WO2019203555A1
(ko)
|
2018-04-17 |
2019-10-24 |
한국생명공학연구원 |
Progranulin 단백질을 포함하는 간질환의 예방 또는 치료용 조성물
|
|
WO2019246071A1
(en)
*
|
2018-06-18 |
2019-12-26 |
Denali Therapeutics Inc. |
Fusion proteins comprising progranulin
|
|
WO2020037150A2
(en)
|
2018-08-16 |
2020-02-20 |
Denali Therapeutics Inc. |
Engineered bispecific proteins
|
|
JP2021534220A
(ja)
|
2018-08-22 |
2021-12-09 |
デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. |
抗her2ポリペプチド及びそれらの使用の方法
|
|
JP7624919B2
(ja)
|
2018-10-16 |
2025-01-31 |
デナリ セラピューティクス インコーポレイテッド |
プログラニュリン関連障害を処置及びモニタリングするための方法
|
|
US20220025065A1
(en)
|
2018-12-10 |
2022-01-27 |
Denali Therapeutics Inc. |
Lysosomal storage disorder biomarkers and methods of use thereof
|
|
CA3134538A1
(en)
|
2019-04-03 |
2020-10-08 |
Denali Therapeutics Inc. |
Formulations of protein molecules comprising iduronate 2-sulfatase
|
|
PH12022551598A1
(en)
|
2019-12-23 |
2023-11-20 |
Denali Therapeutics Inc |
Progranulin variants
|
|
JP2023512450A
(ja)
|
2020-01-13 |
2023-03-27 |
デナリ セラピューティクス インコーポレイテッド |
抗trem2抗体及びその使用方法
|
|
WO2021158986A1
(en)
|
2020-02-07 |
2021-08-12 |
Denali Therapeutics Inc. |
Methods for the treatment of hunter syndrome
|
|
EP4229192A1
(en)
|
2020-10-14 |
2023-08-23 |
Denali Therapeutics Inc. |
Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
|
|
WO2022082178A2
(en)
|
2020-10-14 |
2022-04-21 |
Denali Therapeutics Inc. |
Methods for treating and monitoring frontotemporal dementia
|