JP2023504143A5 - - Google Patents
Info
- Publication number
- JP2023504143A5 JP2023504143A5 JP2022532095A JP2022532095A JP2023504143A5 JP 2023504143 A5 JP2023504143 A5 JP 2023504143A5 JP 2022532095 A JP2022532095 A JP 2022532095A JP 2022532095 A JP2022532095 A JP 2022532095A JP 2023504143 A5 JP2023504143 A5 JP 2023504143A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- nhr
- alkyl
- aryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PLPCT/PL2019/000108 | 2019-11-27 | ||
| PL2019000108 | 2019-11-27 | ||
| PCT/EP2020/083597 WO2021105335A1 (en) | 2019-11-27 | 2020-11-27 | Piperidine-2, 6-dione derivatives which bind to cereblon, and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504143A JP2023504143A (ja) | 2023-02-01 |
| JP2023504143A5 true JP2023504143A5 (https=) | 2023-12-05 |
| JP7760167B2 JP7760167B2 (ja) | 2025-10-27 |
Family
ID=69024571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022532095A Active JP7760167B2 (ja) | 2019-11-27 | 2020-11-27 | セレブロンに結合するピペリジン－２，６－ジオン誘導体、及びその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230065745A1 (https=) |
| EP (1) | EP4065576A1 (https=) |
| JP (1) | JP7760167B2 (https=) |
| WO (1) | WO2021105335A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022255888A1 (en) * | 2021-06-01 | 2022-12-08 | Captor Therapeutics S.A. | Targeted protein degradation using bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| CN113501807A (zh) * | 2021-06-10 | 2021-10-15 | 重庆科技学院 | 四氢苯并噻吩类化合物及药物组合物的制备方法和用途 |
| IL311606A (en) * | 2021-09-27 | 2024-05-01 | Univ Pennsylvania | Molluscum contagiosum infection inhibitors and methods of using them |
| WO2023101556A1 (en) * | 2021-12-02 | 2023-06-08 | Rijksuniversiteit Groningen | Novel inhibitors of aspartate transcarbamoylase (atcase) and compositions, methods and uses related thereto. |
| EP4626875A1 (en) * | 2022-12-02 | 2025-10-08 | Avammune Therapeutics Inc. | Adar1 inhibitors and methods of using the same |
| WO2024123195A1 (en) * | 2022-12-06 | 2024-06-13 | Captor Therapeutics S.A. | Targeted protein degradation using prodrugs of bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| KR20250130610A (ko) * | 2022-12-06 | 2025-09-02 | 캡터 테라퓨틱스 에스.에이. | 유비퀴틴 리가제 및 표적 mcl-1 단백질에 결합하는 이작용성 화합물을 사용하는 표적화된 단백질 분해 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| JP2002105073A (ja) * | 2000-09-27 | 2002-04-10 | Shionogi & Co Ltd | 新規マトリックスメタロプロテアーゼ阻害剤 |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| CN1939922B (zh) * | 2005-09-27 | 2010-10-13 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的5H-噻吩[3，4-c]吡咯-4，6-二酮衍生物 |
| CL2007002513A1 (es) | 2006-08-30 | 2008-04-04 | Celgene Corp Soc Organizada Ba | Compuestos derivados de isoindolina sustituidos, compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento y prevencion de enfermedades tales como cancer, dolor, degeneracion macular, entre otras. |
| ES2565683T3 (es) * | 2006-09-15 | 2016-04-06 | Xcovery, Inc. | Compuestos inhibidores de quinasa |
| ME02420B (me) | 2006-09-26 | 2016-09-20 | Celgene Corp | 5-supstituirani derivati kinazolinona kao sredstva protiv raka |
| PL3202460T3 (pl) | 2010-02-11 | 2019-12-31 | Celgene Corporation | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| BR112018068906A2 (pt) * | 2016-03-16 | 2019-01-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | composição, método, método de redução de risco, prevenção ou tratamento de um indivíduo que tem uma doença ou distúrbio autoimune, método de indução de degradação de uma proteína-alvo numa célula, método para reduzir o risco, prevenir ou tratar um estado da doença ou afecção num paciente em que a atividade proteica desregulada é responsável pelo referido estado da doença ou afecção, método para reduzir o risco, prevenir ou tratar câncer num indivíduo e método de tratamento de uma doença ou distúrbio genético num indivíduo |
| EP3454856B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109790143A (zh) * | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| EP4467143B1 (en) | 2017-07-10 | 2026-03-11 | Celgene Corporation | Method for preparing 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile |
| CN118108706A (zh) * | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| CA3094988A1 (en) * | 2018-03-30 | 2019-10-03 | Biotheryx, Inc. | Thienopyrimidinone compounds |
-
2020
- 2020-11-27 WO PCT/EP2020/083597 patent/WO2021105335A1/en not_active Ceased
- 2020-11-27 EP EP20838351.3A patent/EP4065576A1/en active Pending
- 2020-11-27 US US17/780,894 patent/US20230065745A1/en active Pending
- 2020-11-27 JP JP2022532095A patent/JP7760167B2/ja active Active
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