JP2001510843A5 - - Google Patents
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- Publication number
- JP2001510843A5 JP2001510843A5 JP2000504140A JP2000504140A JP2001510843A5 JP 2001510843 A5 JP2001510843 A5 JP 2001510843A5 JP 2000504140 A JP2000504140 A JP 2000504140A JP 2000504140 A JP2000504140 A JP 2000504140A JP 2001510843 A5 JP2001510843 A5 JP 2001510843A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- hydroxy
- phenyl
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 description 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 9
- 229910052736 halogen Inorganic materials 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 150000002367 halogens Chemical class 0.000 description 5
- 125000001424 substituent group Chemical group 0.000 description 5
- 0 *C(C(*)C(C1)[n](c2n3)nnc2c(*)nc3S)C1C(*)=O Chemical compound *C(C(*)C(C1)[n](c2n3)nnc2c(*)nc3S)C1C(*)=O 0.000 description 4
- 125000005843 halogen group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- LWPIWGSZKJFTEK-MAZHCROVSA-N 2-[[(1s,3r,4s)-3-[7-(butylamino)-5-[4-(trifluoromethyl)phenyl]sulfanyltriazolo[4,5-d]pyrimidin-3-yl]-4-hydroxycyclopentanecarbonyl]amino]acetic acid Chemical compound N=1C=2N([C@H]3[C@H](C[C@H](C3)C(=O)NCC(O)=O)O)N=NC=2C(NCCCC)=NC=1SC1=CC=C(C(F)(F)F)C=C1 LWPIWGSZKJFTEK-MAZHCROVSA-N 0.000 description 1
- WBYPGPWRYRTEKC-XQQFMLRXSA-N 2-[[(1s,3r,4s)-3-[7-(butylamino)-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-4-hydroxycyclopentanecarbonyl]amino]acetic acid Chemical compound N1=NC=2C(NCCCC)=NC(SCCC)=NC=2N1[C@@H]1C[C@H](C(=O)NCC(O)=O)C[C@@H]1O WBYPGPWRYRTEKC-XQQFMLRXSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000006309 butyl amino group Chemical group 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 150000003951 lactams Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9702774-2 | 1997-07-22 | ||
| SE9702774A SE9702774D0 (sv) | 1997-07-22 | 1997-07-22 | Novel compounds |
| PCT/SE1998/001394 WO1999005144A1 (en) | 1997-07-22 | 1998-07-15 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001510843A JP2001510843A (ja) | 2001-08-07 |
| JP2001510843A5 true JP2001510843A5 (https=) | 2006-01-05 |
Family
ID=20407805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000504140A Pending JP2001510843A (ja) | 1997-07-22 | 1998-07-15 | 新規な化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6166022A (https=) |
| EP (1) | EP0998475B1 (https=) |
| JP (1) | JP2001510843A (https=) |
| KR (1) | KR20010022084A (https=) |
| CN (1) | CN1270591A (https=) |
| AT (1) | ATE216390T1 (https=) |
| AU (1) | AU8370798A (https=) |
| BR (1) | BR9811028A (https=) |
| CA (1) | CA2296426A1 (https=) |
| DE (1) | DE69804966T2 (https=) |
| EE (1) | EE200000048A (https=) |
| HU (1) | HUP0003826A3 (https=) |
| ID (1) | ID25856A (https=) |
| IL (1) | IL134111A0 (https=) |
| IS (1) | IS5352A (https=) |
| NO (1) | NO20000313L (https=) |
| PL (1) | PL338181A1 (https=) |
| SE (1) | SE9702774D0 (https=) |
| SK (1) | SK188299A3 (https=) |
| TR (1) | TR200000152T2 (https=) |
| WO (1) | WO1999005144A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702773D0 (sv) * | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| NZ505250A (en) * | 1998-02-17 | 2002-10-25 | Astrazeneca Uk Ltd | Novel triazolo(4,5-d) pyrimidine compounds and pharmaceuticals thereof. |
| CA2380656A1 (en) * | 1999-09-09 | 2001-03-15 | Nadine Derrien | Substituted cyclopentenes, their preparation and their use for chiral scaffolds |
| SE9904129D0 (sv) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| AR039558A1 (es) * | 2000-08-21 | 2005-02-23 | Inspire Pharmaceuticals Inc | Composiciones y metodo para el tratamiento de glaucoma o hipertension ocular |
| US7132408B2 (en) * | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
| US6897201B2 (en) | 2000-08-21 | 2005-05-24 | Inspire Pharmaceuticals, Inc. | Compositions and methods for the treatment of glaucoma or ocular hypertension |
| US7435724B2 (en) | 2002-02-27 | 2008-10-14 | Inspire Pharmaceutical, Inc. | Degradation-resistant mononucleoside phosphate compounds |
| JP4879745B2 (ja) | 2003-10-03 | 2012-02-22 | ポートラ ファーマシューティカルズ， インコーポレイテッド | 置換イソキノリノン |
| AU2004278030C1 (en) | 2003-10-03 | 2010-12-02 | Portola Pharmaceuticals, Inc. | 2,4-Dioxo-3-quinazolinylaryl sulfonylureas |
| US7504497B2 (en) | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
| AU2004284098B2 (en) | 2003-10-21 | 2009-07-16 | Inspire Pharmaceuticals, Inc. | Tetrahydro-furo [3,4-d] dioxole compounds and compositions and method for inhibiting platelet aggregation |
| US7335648B2 (en) | 2003-10-21 | 2008-02-26 | Inspire Pharmaceuticals, Inc. | Non-nucleotide composition and method for inhibiting platelet aggregation |
| US7749981B2 (en) | 2003-10-21 | 2010-07-06 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound |
| CN101031565B (zh) | 2004-09-29 | 2010-09-29 | 博尔托拉制药公司 | 取代的2h-1,3-苯并噁嗪-4(3h)-酮 |
| US7932376B2 (en) | 2005-05-05 | 2011-04-26 | Inspire Pharmaceuticals, Inc. | Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation |
| JPWO2007020935A1 (ja) * | 2005-08-17 | 2009-02-26 | 小野薬品工業株式会社 | Ｐ２ｙ１２受容体および／またはｐ２ｙ１４受容体ブロッカーを含有してなる疼痛治療剤 |
| KR101423483B1 (ko) | 2005-11-03 | 2014-07-28 | 포톨라 파마슈티컬스, 인코포레이티드 | 〔４-(６-할로-７-치환된-２,４-디옥소-１,４-디히드로-２ｈ-퀴나졸린-３-일)-페닐〕-５-클로로티오펜-２-일-설포닐우레아 및 이의 형태 및 이와 관련된 방법 |
| JP2010508350A (ja) | 2006-10-31 | 2010-03-18 | ヤンセン ファーマシューティカ エヌ．ベー． | Ａｄｐｐ２ｙ１２レセプターアンタゴニストとしてのトリアゾロピリミジン誘導体 |
| WO2011133871A2 (en) * | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
| WO2011150205A2 (en) * | 2010-05-27 | 2011-12-01 | Dr. Reddy's Laboratories Ltd. | Highly selective asymmetric hydroformylation of (1s,4r) or (1r,4s)-2-azabicyclo[2.2.1]hept-5-en-3- one (+) or (-)-lactam |
| US9458244B2 (en) | 2012-12-28 | 2016-10-04 | Abbvie Inc. | Single chain multivalent binding protein compositions and methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4742064A (en) * | 1985-09-10 | 1988-05-03 | Regents Of The University Of Minnesota | Antiviral carbocyclic analogs of xylofuranosylpurines |
| GB8826205D0 (en) * | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
| EP0684953A4 (en) * | 1993-02-03 | 1999-12-22 | Gensia Inc | ADENOSINE KINASE INHIBITORS COMPRISING LYXOFURANOSYL DERIVATIVES. |
| TR199800019T1 (xx) * | 1995-07-11 | 1998-05-21 | Astra Pharmaceuticals Limited | Trombosit topaklanmas�n� �nleyici yeni maddeler. |
-
1997
- 1997-07-22 SE SE9702774A patent/SE9702774D0/xx unknown
-
1998
- 1998-07-15 AU AU83707/98A patent/AU8370798A/en not_active Abandoned
- 1998-07-15 TR TR2000/00152T patent/TR200000152T2/xx unknown
- 1998-07-15 KR KR1020007000653A patent/KR20010022084A/ko not_active Withdrawn
- 1998-07-15 JP JP2000504140A patent/JP2001510843A/ja active Pending
- 1998-07-15 IL IL13411198A patent/IL134111A0/xx unknown
- 1998-07-15 SK SK1882-99A patent/SK188299A3/sk unknown
- 1998-07-15 PL PL98338181A patent/PL338181A1/xx not_active Application Discontinuation
- 1998-07-15 ID IDW20000145D patent/ID25856A/id unknown
- 1998-07-15 CA CA002296426A patent/CA2296426A1/en not_active Abandoned
- 1998-07-15 WO PCT/SE1998/001394 patent/WO1999005144A1/en not_active Ceased
- 1998-07-15 CN CN98809157A patent/CN1270591A/zh active Pending
- 1998-07-15 DE DE69804966T patent/DE69804966T2/de not_active Expired - Fee Related
- 1998-07-15 US US09/155,567 patent/US6166022A/en not_active Expired - Fee Related
- 1998-07-15 HU HU0003826A patent/HUP0003826A3/hu unknown
- 1998-07-15 EP EP98934108A patent/EP0998475B1/en not_active Expired - Lifetime
- 1998-07-15 BR BR9811028-4A patent/BR9811028A/pt not_active IP Right Cessation
- 1998-07-15 EE EEP200000048A patent/EE200000048A/xx unknown
- 1998-07-15 AT AT98934108T patent/ATE216390T1/de active
-
2000
- 2000-01-19 IS IS5352A patent/IS5352A/is unknown
- 2000-01-21 NO NO20000313A patent/NO20000313L/no not_active Application Discontinuation
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