JP2023154020A5 - - Google Patents
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- Publication number
- JP2023154020A5 JP2023154020A5 JP2023130574A JP2023130574A JP2023154020A5 JP 2023154020 A5 JP2023154020 A5 JP 2023154020A5 JP 2023130574 A JP2023130574 A JP 2023130574A JP 2023130574 A JP2023130574 A JP 2023130574A JP 2023154020 A5 JP2023154020 A5 JP 2023154020A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- acceptable carrier
- excipient
- dermatologically acceptable
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000002500 effect on skin Effects 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 2
- 239000004264 Petrolatum Substances 0.000 claims 2
- 208000009621 actinic keratosis Diseases 0.000 claims 2
- 230000037444 atrophy Effects 0.000 claims 2
- 239000003974 emollient agent Substances 0.000 claims 2
- 229940066842 petrolatum Drugs 0.000 claims 2
- 235000019271 petrolatum Nutrition 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000008387 emulsifying waxe Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000003349 gelling agent Substances 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000008719 thickening Effects 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562232228P | 2015-09-24 | 2015-09-24 | |
| US62/232,228 | 2015-09-24 | ||
| JP2018515561A JP2018528236A (ja) | 2015-09-24 | 2016-09-19 | 真皮障害を治療または予防するための新規組成物および方法 |
| PCT/US2016/052442 WO2017053222A1 (en) | 2015-09-24 | 2016-09-19 | Novel compositions and methods for treating or preventing dermal disorders |
| JP2021169263A JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021169263A Division JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023154020A JP2023154020A (ja) | 2023-10-18 |
| JP2023154020A5 true JP2023154020A5 (https=) | 2024-04-08 |
| JP7573078B2 JP7573078B2 (ja) | 2024-10-24 |
Family
ID=58387119
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515561A Withdrawn JP2018528236A (ja) | 2015-09-24 | 2016-09-19 | 真皮障害を治療または予防するための新規組成物および方法 |
| JP2021169263A Active JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
| JP2023130574A Active JP7573078B2 (ja) | 2015-09-24 | 2023-08-10 | 真皮障害を治療または予防するための新規組成物および方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515561A Withdrawn JP2018528236A (ja) | 2015-09-24 | 2016-09-19 | 真皮障害を治療または予防するための新規組成物および方法 |
| JP2021169263A Active JP7332666B2 (ja) | 2015-09-24 | 2021-10-15 | 真皮障害を治療または予防するための新規組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10695326B2 (https=) |
| EP (2) | EP4729121A2 (https=) |
| JP (3) | JP2018528236A (https=) |
| KR (1) | KR20180081501A (https=) |
| CN (2) | CN108348508A (https=) |
| AU (1) | AU2016325446B2 (https=) |
| CA (1) | CA3037469C (https=) |
| ES (1) | ES3060762T3 (https=) |
| WO (1) | WO2017053222A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014209141B2 (en) | 2013-01-24 | 2018-05-10 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mTOR inhibitors |
| CA3037469C (en) * | 2015-09-24 | 2024-04-16 | Drexel University | Treatment of dermal disorders comprising a mtorc1 inhibitor |
| EP3496712A1 (en) * | 2016-08-10 | 2019-06-19 | The Board of Regents of The University of Texas System | Topical rapamycin therapy |
| EP3565520B1 (en) | 2017-01-06 | 2026-02-25 | Palvella Therapeutics, Inc. | Anhydrous compositions of mtor inhibitors and methods of use |
| US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
| CN112955126A (zh) * | 2018-10-11 | 2021-06-11 | 德雷克塞尔大学 | 治疗或预防皮肤状况的方法 |
| JP7516252B2 (ja) * | 2018-11-02 | 2024-07-16 | 株式会社 資生堂 | オルタナティブオートファジー誘導剤を含む紫外線起因性炎症抑制剤 |
| KR102132921B1 (ko) * | 2018-12-13 | 2020-07-13 | 영남대학교 산학협력단 | 조타로리무스를 유효성분으로 함유하는 세포노화 관련 질환 예방 또는 치료용 조성물 |
| AU2020277132B1 (en) * | 2020-11-24 | 2021-11-04 | Aft Pharmaceuticals Limited | A Rapamycin Composition |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5286730A (en) | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory disease |
| GB9723669D0 (en) | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
| US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
| US20040180430A1 (en) | 1999-09-07 | 2004-09-16 | West Michael D. | Methods of restoring telomere length and extending cell lifespan using nuclear transfer |
| US7026374B2 (en) | 2002-06-25 | 2006-04-11 | Aruna Nathan | Injectable microdispersions for medical applications |
| EP1646635A1 (en) | 2003-07-16 | 2006-04-19 | Wyeth | Cci-779 isomer c |
| US20050250805A1 (en) * | 2004-05-06 | 2005-11-10 | Glenmark Pharmaceuticals Limited | Pharmaceutical ointment formulations |
| KR20070121746A (ko) | 2005-03-14 | 2007-12-27 | 매크로켐 코포레이션 | 사람 피부를 통한 마크롤라이드 침투의 개선 |
| ES2563288T3 (es) | 2006-03-23 | 2016-03-14 | Santen Pharmaceutical Co., Ltd | Rapamicina en dosis bajas para el tratamiento de enfermedades relacionadas con la permeabilidad vascular |
| MXPA06008797A (es) * | 2006-08-03 | 2008-02-04 | Fernando Ahumada Ayala | Preparacion topica para el tratamiento de enfermedades inflamatorias de la piel que contiene sirolimus. |
| WO2008022256A2 (en) | 2006-08-16 | 2008-02-21 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
| US20100278784A1 (en) | 2007-05-15 | 2010-11-04 | Puretech Ventures | Methods and compositions for treating skin conditions |
| WO2009046436A1 (en) | 2007-10-04 | 2009-04-09 | Memorial Sloan-Kettering Cancer Center | Methods for inhibiting senescence of epithelial cells |
| PT2362866E (pt) | 2008-11-11 | 2015-10-26 | Signum Biosciences Inc | Compostos de isoprenila e métodos dos mesmos |
| BRPI1010655A2 (pt) | 2009-04-10 | 2019-09-03 | Qi Haiyan | novos agentes antienvelhecimento e métodos para identificá-los |
| AU2013204219B2 (en) * | 2009-04-10 | 2015-05-07 | Haiyan Qi | Novel anti-aging agents and methods to identify them |
| US20110150856A1 (en) | 2009-12-21 | 2011-06-23 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
| WO2011079154A1 (en) * | 2009-12-21 | 2011-06-30 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
| CA2825786A1 (en) * | 2011-01-31 | 2012-08-09 | Osaka University | Externally-used drug for treating skin disorder and method for producing same |
| WO2012142145A1 (en) | 2011-04-12 | 2012-10-18 | Dow Pharmaceutical Sciences | Methods of treating skin conditions exhibiting telangiectasia |
| WO2013070976A1 (en) * | 2011-11-08 | 2013-05-16 | Intellikine, Llc | Treatment regimens using multiple pharmaceutical agents |
| US20150202187A1 (en) | 2012-06-26 | 2015-07-23 | Sarah Bacus | Compositions and methods for treatment of vitiligo |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| AU2014348657A1 (en) * | 2013-11-13 | 2016-05-19 | Novartis Ag | mTOR inhibitors for enhancing the immune response |
| US9980976B2 (en) * | 2015-02-17 | 2018-05-29 | Northwestern University | Use of REDD1 inhibitors to dissociate therapeutic and adverse atrophogenic effects of glucocorticoid receptor agonists |
| CA3037469C (en) * | 2015-09-24 | 2024-04-16 | Drexel University | Treatment of dermal disorders comprising a mtorc1 inhibitor |
-
2016
- 2016-09-19 CA CA3037469A patent/CA3037469C/en active Active
- 2016-09-19 ES ES16849389T patent/ES3060762T3/es active Active
- 2016-09-19 CN CN201680065172.4A patent/CN108348508A/zh active Pending
- 2016-09-19 AU AU2016325446A patent/AU2016325446B2/en active Active
- 2016-09-19 JP JP2018515561A patent/JP2018528236A/ja not_active Withdrawn
- 2016-09-19 EP EP25225780.3A patent/EP4729121A2/en active Pending
- 2016-09-19 WO PCT/US2016/052442 patent/WO2017053222A1/en not_active Ceased
- 2016-09-19 KR KR1020187011292A patent/KR20180081501A/ko not_active Ceased
- 2016-09-19 US US15/762,317 patent/US10695326B2/en active Active
- 2016-09-19 EP EP16849389.8A patent/EP3352755B1/en active Active
- 2016-09-19 CN CN202211246255.7A patent/CN115645534A/zh active Pending
-
2020
- 2020-05-21 US US16/880,186 patent/US11179374B2/en active Active
-
2021
- 2021-08-11 US US17/399,763 patent/US20220031673A1/en active Pending
- 2021-10-15 JP JP2021169263A patent/JP7332666B2/ja active Active
-
2023
- 2023-08-10 JP JP2023130574A patent/JP7573078B2/ja active Active
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