CN108348508A - 治疗或预防皮肤障碍的新型组合物和方法 - Google Patents

治疗或预防皮肤障碍的新型组合物和方法 Download PDF

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Publication number
CN108348508A
CN108348508A CN201680065172.4A CN201680065172A CN108348508A CN 108348508 A CN108348508 A CN 108348508A CN 201680065172 A CN201680065172 A CN 201680065172A CN 108348508 A CN108348508 A CN 108348508A
Authority
CN
China
Prior art keywords
rapamycin
skin
cells
fibroblasts
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680065172.4A
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English (en)
Chinese (zh)
Inventor
C·赛尔
T·拿卡瑞丽
A·阿扎尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Drexel University
Original Assignee
Drexel University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drexel University filed Critical Drexel University
Priority to CN202211246255.7A priority Critical patent/CN115645534A/zh
Publication of CN108348508A publication Critical patent/CN108348508A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680065172.4A 2015-09-24 2016-09-19 治疗或预防皮肤障碍的新型组合物和方法 Pending CN108348508A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211246255.7A CN115645534A (zh) 2015-09-24 2016-09-19 治疗或预防皮肤障碍的新型组合物和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562232228P 2015-09-24 2015-09-24
US62/232,228 2015-09-24
PCT/US2016/052442 WO2017053222A1 (en) 2015-09-24 2016-09-19 Novel compositions and methods for treating or preventing dermal disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211246255.7A Division CN115645534A (zh) 2015-09-24 2016-09-19 治疗或预防皮肤障碍的新型组合物和方法

Publications (1)

Publication Number Publication Date
CN108348508A true CN108348508A (zh) 2018-07-31

Family

ID=58387119

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680065172.4A Pending CN108348508A (zh) 2015-09-24 2016-09-19 治疗或预防皮肤障碍的新型组合物和方法
CN202211246255.7A Pending CN115645534A (zh) 2015-09-24 2016-09-19 治疗或预防皮肤障碍的新型组合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202211246255.7A Pending CN115645534A (zh) 2015-09-24 2016-09-19 治疗或预防皮肤障碍的新型组合物和方法

Country Status (9)

Country Link
US (3) US10695326B2 (https=)
EP (2) EP4729121A2 (https=)
JP (3) JP2018528236A (https=)
KR (1) KR20180081501A (https=)
CN (2) CN108348508A (https=)
AU (1) AU2016325446B2 (https=)
CA (1) CA3037469C (https=)
ES (1) ES3060762T3 (https=)
WO (1) WO2017053222A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112955126A (zh) * 2018-10-11 2021-06-11 德雷克塞尔大学 治疗或预防皮肤状况的方法

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AU2014209141B2 (en) 2013-01-24 2018-05-10 Palvella Therapeutics, Inc. Compositions for transdermal delivery of mTOR inhibitors
CA3037469C (en) * 2015-09-24 2024-04-16 Drexel University Treatment of dermal disorders comprising a mtorc1 inhibitor
EP3496712A1 (en) * 2016-08-10 2019-06-19 The Board of Regents of The University of Texas System Topical rapamycin therapy
EP3565520B1 (en) 2017-01-06 2026-02-25 Palvella Therapeutics, Inc. Anhydrous compositions of mtor inhibitors and methods of use
US11000513B2 (en) 2018-07-02 2021-05-11 Palvella Therapeutics, Inc. Anhydrous compositions of mTOR inhibitors and methods of use
JP7516252B2 (ja) * 2018-11-02 2024-07-16 株式会社 資生堂 オルタナティブオートファジー誘導剤を含む紫外線起因性炎症抑制剤
KR102132921B1 (ko) * 2018-12-13 2020-07-13 영남대학교 산학협력단 조타로리무스를 유효성분으로 함유하는 세포노화 관련 질환 예방 또는 치료용 조성물
AU2020277132B1 (en) * 2020-11-24 2021-11-04 Aft Pharmaceuticals Limited A Rapamycin Composition

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WO2009046436A1 (en) * 2007-10-04 2009-04-09 Memorial Sloan-Kettering Cancer Center Methods for inhibiting senescence of epithelial cells
WO2013070976A1 (en) * 2011-11-08 2013-05-16 Intellikine, Llc Treatment regimens using multiple pharmaceutical agents
US20160235763A1 (en) * 2015-02-17 2016-08-18 Northwestern University Use of redd1 inhibitors to dissociate therapeutic and adverse atrophogenic effects of glucocorticoid receptor agonists

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US20040180430A1 (en) 1999-09-07 2004-09-16 West Michael D. Methods of restoring telomere length and extending cell lifespan using nuclear transfer
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
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US20050250805A1 (en) * 2004-05-06 2005-11-10 Glenmark Pharmaceuticals Limited Pharmaceutical ointment formulations
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MXPA06008797A (es) * 2006-08-03 2008-02-04 Fernando Ahumada Ayala Preparacion topica para el tratamiento de enfermedades inflamatorias de la piel que contiene sirolimus.
WO2008022256A2 (en) 2006-08-16 2008-02-21 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
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BRPI1010655A2 (pt) 2009-04-10 2019-09-03 Qi Haiyan novos agentes antienvelhecimento e métodos para identificá-los
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US20110150856A1 (en) 2009-12-21 2011-06-23 Sarah Bacus Compositions and methods for treatment of vitiligo
WO2011079154A1 (en) * 2009-12-21 2011-06-30 Sarah Bacus Compositions and methods for treatment of vitiligo
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CA3037469C (en) * 2015-09-24 2024-04-16 Drexel University Treatment of dermal disorders comprising a mtorc1 inhibitor

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WO2009046436A1 (en) * 2007-10-04 2009-04-09 Memorial Sloan-Kettering Cancer Center Methods for inhibiting senescence of epithelial cells
WO2013070976A1 (en) * 2011-11-08 2013-05-16 Intellikine, Llc Treatment regimens using multiple pharmaceutical agents
US20160235763A1 (en) * 2015-02-17 2016-08-18 Northwestern University Use of redd1 inhibitors to dissociate therapeutic and adverse atrophogenic effects of glucocorticoid receptor agonists

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112955126A (zh) * 2018-10-11 2021-06-11 德雷克塞尔大学 治疗或预防皮肤状况的方法

Also Published As

Publication number Publication date
US20180280362A1 (en) 2018-10-04
JP2022009168A (ja) 2022-01-14
JP7573078B2 (ja) 2024-10-24
US10695326B2 (en) 2020-06-30
AU2016325446A1 (en) 2018-04-19
HK1258696A1 (en) 2019-11-15
KR20180081501A (ko) 2018-07-16
US20220031673A1 (en) 2022-02-03
EP3352755A4 (en) 2019-04-03
CN115645534A (zh) 2023-01-31
CA3037469C (en) 2024-04-16
CA3037469A1 (en) 2017-03-30
EP4729121A2 (en) 2026-04-22
WO2017053222A1 (en) 2017-03-30
JP2023154020A (ja) 2023-10-18
EP3352755B1 (en) 2025-12-24
US20200281903A1 (en) 2020-09-10
JP7332666B2 (ja) 2023-08-23
AU2016325446B2 (en) 2021-05-13
EP3352755A1 (en) 2018-08-01
JP2018528236A (ja) 2018-09-27
US11179374B2 (en) 2021-11-23
ES3060762T3 (en) 2026-03-30

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