JP4359140B2 - 異常な角質性物質を除去するための製剤 - Google Patents
異常な角質性物質を除去するための製剤 Download PDFInfo
- Publication number
- JP4359140B2 JP4359140B2 JP2003501422A JP2003501422A JP4359140B2 JP 4359140 B2 JP4359140 B2 JP 4359140B2 JP 2003501422 A JP2003501422 A JP 2003501422A JP 2003501422 A JP2003501422 A JP 2003501422A JP 4359140 B2 JP4359140 B2 JP 4359140B2
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- urea
- water
- alcohol
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Description
のBifonazol(登録商標)1%を含む軟膏が、絞り出すための補助材の撥水性のプラスタ
ーおよびネイルスクレーパーを一緒に包装され、ネイルセット(Mycospor−登録商標)として市販されている。これらの製剤は、10年以上にわたって市販されてきた(Bang DS,
Lee YD, Whang KK, Lee SN: Therapeutic trial of ointment base including urea and antifungal agent as the treatment of onychomycosis. Ann Dermatol 1991; 3: 32-6;Hay RJ, Roberts DT, Doherty VR, Richardson MD, Midglay G. The topical treatment of onychomycosis using a new combined urea/imidazole preparation. Clin Exper Dermatol 1988; 13: 164-167)。
なる製剤を提供することにより上述の欠点を改良することを目的とする。
a)製剤の非揮発性構成成分に基づいて40〜70重量%の量の尿素、
b)親水性フィルム形成剤、および
c)水またはアルコール−水混合物
を含む処方を提供する。
a)製剤の非揮発性構成成分に基づいて30重量%〜90重量%の量の尿素、
b)親水性フィルム形成剤、および
c)水またはアルコール−水混合物
を含む製剤の、異常なケラチン性物質の処置および除去のための医薬の製造における使用に関する。
ルム形成剤含量を有する処方に比べて乾燥時間が短いので、有利である。
尿素 30%
ポリビニルピロリドン(分子量約11 500) 20%
鉱物質除去水 50%
尿素 30%
ポリビニルピロリドン(分子量約11 500) 20%
エタノール 20%
鉱物質除去水 30%
尿素 30%
ポリビニルピロリドン(分子量約11 500) 20%
プロパン-2-オール 20%
乳酸 1%
鉱物質除去水 29%
尿素 30%
ポリビニルピロリドン(分子量約11 500) 20%
乳酸 1%
鉱物質除去水 49%
尿素 30%
ポリビニルピロリドン(分子量約11 500) 20%
プロパン2-オール 20%
鉱物質除去水 30%
尿素 30%
ポリビニルピロリドン(分子量約11 500) 20%
クレモフォール EL 1%
乳酸 1%
鉱物質除去水 48%
2例の罹病患者の足指を実施例3の製剤で処置した。
実施例3に記載の本発明の製剤を、1日1回就寝前に刷毛で、患部の爪に適用した。爪に適用後に形成される尿素含有フィルムは、拭き取られるのに対し抵抗性を示し、撥水性であった。したがって、爪周囲の皮膚領域に対する特別な保護およびプラスター包帯の適用は不必要であった。製剤の高い水分含量のために、患部の足指をさらに水で浸すことはしなかった。
約6日間処置したのち、爪の患部領域および爪下の組織残渣はスクレーパーで容易に除去された。爪のひどい脆さは消失し、重篤な角質層の肥厚の重症度は中等度まで改善した。
約6日間処置したのち、第二の患者では爪の脆さは消失し、重篤な角質増殖症はもはや存在しなかった。すなわち、良好な治療の成功を示した。
いずれの患者も良好な治療結果を示した。本発明の製剤の許容性はきわめて良好であった。両患者とも本発明の製剤の取り扱い易さにはきわめて満足であった。
Claims (5)
- a)製剤の非揮発性構成成分に基づいて41重量%〜69重量%の量の尿素、
b)アクリル酸/メタクリル酸エステルコポリマー、ポリビニルピロリドン、ポリビニルアルコール、酢酸ビニル/ビニルピロリドンコポリマー、酢酸ビニル/クロトン酸コポリマー、メチルビニルエーテル/マレイン酸コポリマー、ポリエステル、ポリエステルアミド、カルボキシメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロースおよびヒドロキシプロピルメチルセルロースまたはそれらの混合物からなる群より選択される、製剤の非揮発性構成成分に基づいて30重量%〜59重量%の親水性フィルム形成剤、および
c)水またはアルコール−水混合物
を含有する製剤。 - 水−アルコール性溶液におけるアルコールには、メタノール、エタノール、プロパノール、イソプロパノール、ブタノール、ペンタノールおよびヘキサノールまたはそれらの混合物からなる群より選択されるアルコールが用いられる請求項1記載の製剤。
- 異常なケラチン性物質の除去のための、請求項1または2記載の製剤。
- 異常なケラチン性物質が疣贅、仮骨、硬化した皮膚、または真菌の攻撃もしくは乾癬疾患により変化した足指および手指の爪からなる群より選択される請求項3記載の製剤。
- 異常に脆くなった足指または手指爪の加湿のための、請求項1または2記載の製剤。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10126501A DE10126501A1 (de) | 2001-05-30 | 2001-05-30 | Zubereitung zur Entfernung von abnormen Keratinmaterial |
PCT/EP2002/005469 WO2002098380A1 (de) | 2001-05-30 | 2002-05-17 | Zubereitung zur entfernung von abnormen keratinmaterial |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2004532268A JP2004532268A (ja) | 2004-10-21 |
JP2004532268A5 JP2004532268A5 (ja) | 2006-01-05 |
JP4359140B2 true JP4359140B2 (ja) | 2009-11-04 |
Family
ID=7686754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003501422A Expired - Fee Related JP4359140B2 (ja) | 2001-05-30 | 2002-05-17 | 異常な角質性物質を除去するための製剤 |
Country Status (11)
Country | Link |
---|---|
US (2) | US20020197291A1 (ja) |
EP (1) | EP1395231B1 (ja) |
JP (1) | JP4359140B2 (ja) |
AT (1) | ATE296607T1 (ja) |
CA (1) | CA2448829C (ja) |
DE (2) | DE10126501A1 (ja) |
DK (1) | DK1395231T3 (ja) |
ES (1) | ES2242027T3 (ja) |
MX (1) | MXPA03009984A (ja) |
PT (1) | PT1395231E (ja) |
WO (1) | WO2002098380A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3157101A (en) * | 2000-01-03 | 2001-07-16 | Manfred Bohn | Preparations for the non-traumatic excision of a nail |
DE10126501A1 (de) * | 2001-05-30 | 2002-12-12 | Aventis Pharma Gmbh | Zubereitung zur Entfernung von abnormen Keratinmaterial |
EP1635779B1 (en) * | 2003-04-24 | 2009-12-09 | L'oreal | Cosmetic peeling method using urea |
BRPI0413902A (pt) * | 2003-08-25 | 2006-10-24 | Bioequal Ag | formulações farmacêuticas e cosméticas |
DE102006049586A1 (de) * | 2006-10-22 | 2008-04-24 | Rudy Susilo | Nagellackenferner für kosmetische und medizinische Anwendungen |
US8293174B2 (en) * | 2007-10-17 | 2012-10-23 | American Sterilizer Company | Prion deactivating composition and methods of using same |
US20090191138A1 (en) * | 2008-01-30 | 2009-07-30 | Mediquest Therapeutics, Inc. | Novel topical formulations for improving the appearance of nails |
NL1035426C2 (nl) * | 2008-05-15 | 2009-11-17 | Atp Marketing & Promotion Ag | Farmaceutische samenstellingen voor de behandeling van wratten. |
FR2937250B1 (fr) * | 2008-10-21 | 2013-05-10 | Fabre Pierre Dermo Cosmetique | Solution filmogene a base d'uree pour le traitement du psorasis de l'ongle |
KR101055963B1 (ko) * | 2008-12-01 | 2011-08-11 | (주)더페이스샵 | 각질 박리 촉진용 화장료 조성물 |
WO2012110430A1 (en) * | 2011-02-10 | 2012-08-23 | Moberg Derma Ab | Novel composition for topical use on a nail |
US8673279B2 (en) | 2011-08-31 | 2014-03-18 | Avon Products, Inc. | Cosmetic liquid extractor comprising nonionic polymers |
US9770609B2 (en) | 2015-04-01 | 2017-09-26 | Neat Feat Products Limited | Urea based skin treatment |
AU2015201680B2 (en) * | 2015-04-01 | 2016-12-22 | Neat Feat Products Limited | Urea based skin treatment |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4402935A (en) * | 1981-04-16 | 1983-09-06 | Del Laboratories, Inc. | Moisturizing nail polish composition |
DE3520098A1 (de) * | 1985-06-05 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | Azolderivate enthaltende formulierungen sowie ihre verwendung zur atraumatischen nagelentfernung |
ATE84208T1 (de) | 1985-11-04 | 1993-01-15 | Owen Galderma Lab Inc | Filmbildende arzneimitteltraeger zur verabreichung von arzneimitteln an naegeln; verfahren zur verwendung. |
DE3544983A1 (de) * | 1985-12-19 | 1987-06-25 | Hoechst Ag | Antimykotisch wirksamer nagellack |
FR2613227B1 (fr) * | 1987-04-01 | 1990-12-28 | Oreal | Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles |
DE3720147A1 (de) | 1987-06-16 | 1988-12-29 | Hoechst Ag | Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung |
US5098421A (en) * | 1989-10-16 | 1992-03-24 | Zook Gerald P | Viscoelastic gel foot padding and medicating device |
DE4212105A1 (de) | 1992-04-10 | 1993-10-14 | Roehm Pharma Gmbh | Nagellack zur Behandlung von Onychomykosen |
US5460620A (en) * | 1992-07-31 | 1995-10-24 | Creative Products Resource, Inc. | Method of applying in-tandem applicator pads for transdermal delivery of a therapeutic agent |
WO1994013257A1 (en) * | 1992-12-16 | 1994-06-23 | Creative Products Resource Associates, Ltd. | Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder |
DE4337945A1 (de) | 1993-11-06 | 1995-05-11 | Labtec Gmbh | Pflaster zur Behandlung von Nagelmykosen |
US5639740A (en) * | 1995-03-10 | 1997-06-17 | Crandall; Wilson Trafton | Topical moisturizing composition and method |
US5834513A (en) * | 1996-04-25 | 1998-11-10 | Avon Products, Inc. | Oxa diacids and related compounds for treating skin conditions |
US5993790A (en) * | 1997-08-04 | 1999-11-30 | Pedinol Pharmacal Inc. | Nail evulsion compositions and method for evulsing nails and treating nail and nail bed infections |
US5919470A (en) * | 1998-04-02 | 1999-07-06 | Bradley Pharmaceuticals, Inc. | Dermatological composition |
AU3157101A (en) | 2000-01-03 | 2001-07-16 | Manfred Bohn | Preparations for the non-traumatic excision of a nail |
US6281239B1 (en) * | 2000-04-12 | 2001-08-28 | Bradley Pharmeaceuticals, Inc. | Method of treating onychomycosis |
DE10126501A1 (de) | 2001-05-30 | 2002-12-12 | Aventis Pharma Gmbh | Zubereitung zur Entfernung von abnormen Keratinmaterial |
US6429231B1 (en) * | 2001-09-24 | 2002-08-06 | Bradley Pharmaceuticals, Inc. | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use |
US6753071B1 (en) * | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
US6495602B1 (en) * | 2001-12-13 | 2002-12-17 | Bradley Pharmaceuticals, Inc. | Topical pharmaceutical base with anti-pruritic and/or anti-inflammatory drugs |
US6673842B2 (en) | 2002-03-20 | 2004-01-06 | Bradley Pharmaceuticals, Inc. | Method of treating onychomycosis |
US6743417B2 (en) | 2002-04-22 | 2004-06-01 | Bradley Pharmaceuticals, Inc. | Method of treating onychomycosis with urea and an antioxidant |
US6573301B1 (en) * | 2002-04-23 | 2003-06-03 | Bradley Pharmaceuticals, Inc. | Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use |
-
2001
- 2001-05-30 DE DE10126501A patent/DE10126501A1/de not_active Withdrawn
-
2002
- 2002-05-17 ES ES02732724T patent/ES2242027T3/es not_active Expired - Lifetime
- 2002-05-17 CA CA2448829A patent/CA2448829C/en not_active Expired - Fee Related
- 2002-05-17 DK DK02732724T patent/DK1395231T3/da active
- 2002-05-17 EP EP02732724A patent/EP1395231B1/de not_active Expired - Lifetime
- 2002-05-17 PT PT02732724T patent/PT1395231E/pt unknown
- 2002-05-17 WO PCT/EP2002/005469 patent/WO2002098380A1/de active IP Right Grant
- 2002-05-17 DE DE50203283T patent/DE50203283D1/de not_active Expired - Lifetime
- 2002-05-17 AT AT02732724T patent/ATE296607T1/de active
- 2002-05-17 MX MXPA03009984A patent/MXPA03009984A/es active IP Right Grant
- 2002-05-17 JP JP2003501422A patent/JP4359140B2/ja not_active Expired - Fee Related
- 2002-05-29 US US10/156,070 patent/US20020197291A1/en not_active Abandoned
-
2004
- 2004-01-15 US US10/757,433 patent/US7476396B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20040146555A1 (en) | 2004-07-29 |
DE50203283D1 (de) | 2005-07-07 |
CA2448829C (en) | 2010-04-20 |
WO2002098380A1 (de) | 2002-12-12 |
US7476396B2 (en) | 2009-01-13 |
MXPA03009984A (es) | 2004-02-12 |
ATE296607T1 (de) | 2005-06-15 |
JP2004532268A (ja) | 2004-10-21 |
DK1395231T3 (da) | 2005-09-12 |
CA2448829A1 (en) | 2002-12-12 |
EP1395231B1 (de) | 2005-06-01 |
PT1395231E (pt) | 2005-08-31 |
ES2242027T3 (es) | 2005-11-01 |
DE10126501A1 (de) | 2002-12-12 |
US20020197291A1 (en) | 2002-12-26 |
EP1395231A1 (de) | 2004-03-10 |
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