JP2023126440A5 - - Google Patents
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- Publication number
- JP2023126440A5 JP2023126440A5 JP2023115231A JP2023115231A JP2023126440A5 JP 2023126440 A5 JP2023126440 A5 JP 2023126440A5 JP 2023115231 A JP2023115231 A JP 2023115231A JP 2023115231 A JP2023115231 A JP 2023115231A JP 2023126440 A5 JP2023126440 A5 JP 2023126440A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- radiolabeled
- medicament
- cancer
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Claims (3)
- 下式の化合物：
- 放射標識化合物の合成における中間体として、請求項１に記載の化合物の使用。
- 前記放射標識化合物が、ガンの治療のための医薬の製造のためのものである、請求項２に記載の使用。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261705513P | 2012-09-25 | 2012-09-25 | |
| US61/705,513 | 2012-09-25 | ||
| JP2019104379A JP6997135B2 (ja) | 2012-09-25 | 2019-06-04 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
| JP2021154188A JP7358430B2 (ja) | 2012-09-25 | 2021-09-22 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021154188A Division JP7358430B2 (ja) | 2012-09-25 | 2021-09-22 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023126440A JP2023126440A (ja) | 2023-09-07 |
| JP2023126440A5 true JP2023126440A5 (ja) | 2023-10-17 |
Family
ID=49887190
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534625A Active JP6562838B2 (ja) | 2012-09-25 | 2013-09-25 | Ｇｒｐｒ陽性ガンの診断画像及び治療適用のための放射標識したｇｒｐｒアンタゴニスト |
| JP2019104379A Active JP6997135B2 (ja) | 2012-09-25 | 2019-06-04 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
| JP2021154188A Active JP7358430B2 (ja) | 2012-09-25 | 2021-09-22 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
| JP2023115231A Pending JP2023126440A (ja) | 2012-09-25 | 2023-07-13 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534625A Active JP6562838B2 (ja) | 2012-09-25 | 2013-09-25 | Ｇｒｐｒ陽性ガンの診断画像及び治療適用のための放射標識したｇｒｐｒアンタゴニスト |
| JP2019104379A Active JP6997135B2 (ja) | 2012-09-25 | 2019-06-04 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
| JP2021154188A Active JP7358430B2 (ja) | 2012-09-25 | 2021-09-22 | Ｇｒｐｒ陽性ガンの検出、診断及び治療のためのｇｒｐｒアンタゴニスト |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US9839703B2 (ja) |
| EP (2) | EP3536347A1 (ja) |
| JP (4) | JP6562838B2 (ja) |
| KR (2) | KR102190005B1 (ja) |
| AU (4) | AU2013323596C1 (ja) |
| BR (1) | BR112015006453B1 (ja) |
| CA (2) | CA3114832A1 (ja) |
| DK (1) | DK2900279T3 (ja) |
| ES (1) | ES2745635T3 (ja) |
| HR (1) | HRP20191620T1 (ja) |
| HU (1) | HUE045724T2 (ja) |
| IL (4) | IL276300B1 (ja) |
| LT (1) | LT2900279T (ja) |
| MX (1) | MX362675B (ja) |
| PL (1) | PL2900279T3 (ja) |
| PT (1) | PT2900279T (ja) |
| RU (1) | RU2693465C9 (ja) |
| SI (1) | SI2900279T1 (ja) |
| WO (1) | WO2014052471A1 (ja) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2729183B1 (en) * | 2011-07-08 | 2018-09-05 | Advanced Accelerator Applications USA, Inc. | Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors |
| EP3536347A1 (en) * | 2012-09-25 | 2019-09-11 | Advanced Accelerator Applications USA, Inc. | Grpr-antagonists for detection, diagnosis and treatment of grpr-positive cancer |
| EP3015462A1 (en) * | 2014-10-29 | 2016-05-04 | OctreoPharm Schiences GmbH | Enantiopure chelating agents for chelator coupled pharmaceuticals, corresponding preparation method thereof and chelator coupled pharmaceuticals |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| US11857352B2 (en) | 2016-09-06 | 2024-01-02 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| CA3044877A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| EP3568205B1 (en) | 2017-01-12 | 2023-08-16 | Radiomedix Inc. | Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes |
| CA3112060A1 (en) * | 2018-10-12 | 2020-04-16 | Advanced Accelerator Applications International Sa | Pharmaceutical composition comprising a radiolabeled gprp antagonist and a surfactant |
| CN113454098A (zh) * | 2018-11-13 | 2021-09-28 | 省卫生服务机构 | 用于胃泌素释放肽受体(grpr)的体内成像和治疗grpr相关病症的放射性标记蛙皮素衍生化合物 |
| SG11202104657RA (en) | 2018-11-23 | 2021-06-29 | Bayer Ag | Formulation of contrast media and process of preparation thereof |
| AR119974A1 (es) * | 2019-09-16 | 2022-01-26 | Advanced Accelerator Applications Italy Srl | Composición radiofarmacéutica concentrada, estable |
| TW202123975A (zh) * | 2019-09-17 | 2021-07-01 | 義大利商先進艾斯雷特應用（義大利）公司 | 放射性標記grpr拮抗劑之方法及其套組 |
| CA3155462A1 (en) * | 2019-09-24 | 2021-04-01 | Novartis Ag | Radiolabelled grpr-antagonist for use as theragnostic |
| CN114845742A (zh) * | 2019-12-19 | 2022-08-02 | 慕尼黑工业大学 | 用于癌症成像和治疗的经改性的grpr拮抗剂肽 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019647A (en) * | 1988-05-24 | 1991-05-28 | Merck & Co., Inc. | Gastrin releasing peptide antagonist |
| US4943561A (en) | 1988-11-28 | 1990-07-24 | Merck & Co., Inc. | Gastrin releasing peptide antagonist |
| US5028692A (en) | 1989-04-25 | 1991-07-02 | Merck & Co., Inc. | Gastrin releasing peptide antagonist |
| JPH04502629A (ja) | 1989-11-06 | 1992-05-14 | フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ | 還元不可逆性ボンベシンアンタゴニスト |
| JPH07505865A (ja) | 1992-02-07 | 1995-06-29 | メレルダウファーマスーティカルズ インコーポレイテッド | ボンベシンのフェニルアラニン類似体類 |
| US5620955A (en) | 1993-06-18 | 1997-04-15 | Peptide Technologies Corporation | Bombesin receptor antagonists and uses thereof |
| US6545125B1 (en) | 1997-11-18 | 2003-04-08 | Chugai Seiyaku Kabushiki Kaisha | Compounds with antitumor activity |
| CA2526556C (en) | 2003-07-24 | 2012-09-25 | Bracco Imaging S.P.A. | Stable radiopharmaceutical compositions and methods for their preparation |
| EP2100900A1 (en) | 2008-03-07 | 2009-09-16 | Universitätsspital Basel | Bombesin analog peptide antagonist conjugates |
| BR112013012503A2 (pt) | 2010-11-22 | 2016-11-08 | Piramal Imaging Sa | análogos de bombesina marcados com 177 lutécio para radioterapia |
| EP2729183B1 (en) * | 2011-07-08 | 2018-09-05 | Advanced Accelerator Applications USA, Inc. | Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors |
| EP3536347A1 (en) * | 2012-09-25 | 2019-09-11 | Advanced Accelerator Applications USA, Inc. | Grpr-antagonists for detection, diagnosis and treatment of grpr-positive cancer |
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2013
- 2013-09-25 EP EP19170067.3A patent/EP3536347A1/en active Pending
- 2013-09-25 WO PCT/US2013/061712 patent/WO2014052471A1/en active Application Filing
- 2013-09-25 PL PL13815181T patent/PL2900279T3/pl unknown
- 2013-09-25 KR KR1020157007572A patent/KR102190005B1/ko active IP Right Grant
- 2013-09-25 CA CA3114832A patent/CA3114832A1/en active Pending
- 2013-09-25 KR KR1020207034970A patent/KR102314293B1/ko active IP Right Grant
- 2013-09-25 AU AU2013323596A patent/AU2013323596C1/en active Active
- 2013-09-25 BR BR112015006453-1A patent/BR112015006453B1/pt active IP Right Grant
- 2013-09-25 LT LT13815181T patent/LT2900279T/lt unknown
- 2013-09-25 IL IL276300A patent/IL276300B1/en unknown
- 2013-09-25 DK DK13815181.6T patent/DK2900279T3/da active
- 2013-09-25 CA CA2886068A patent/CA2886068C/en active Active
- 2013-09-25 US US14/431,096 patent/US9839703B2/en active Active
- 2013-09-25 JP JP2015534625A patent/JP6562838B2/ja active Active
- 2013-09-25 EP EP13815181.6A patent/EP2900279B1/en active Active
- 2013-09-25 HU HUE13815181A patent/HUE045724T2/hu unknown
- 2013-09-25 PT PT138151816T patent/PT2900279T/pt unknown
- 2013-09-25 MX MX2015003772A patent/MX362675B/es active IP Right Grant
- 2013-09-25 SI SI201331585T patent/SI2900279T1/sl unknown
- 2013-09-25 ES ES13815181T patent/ES2745635T3/es active Active
- 2013-09-25 RU RU2015115529A patent/RU2693465C9/ru active
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2015
- 2015-03-19 IL IL237844A patent/IL237844B/en active IP Right Review Request
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2017
- 2017-11-20 US US15/817,776 patent/US20180133349A1/en not_active Abandoned
- 2017-12-28 IL IL256649A patent/IL256649B/en active IP Right Grant
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2018
- 2018-06-21 AU AU2018204513A patent/AU2018204513C1/en active Active
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2019
- 2019-06-04 JP JP2019104379A patent/JP6997135B2/ja active Active
- 2019-08-16 AU AU2019216714A patent/AU2019216714B2/en active Active
- 2019-09-09 HR HRP20191620 patent/HRP20191620T1/hr unknown
- 2019-09-24 US US16/580,990 patent/US11083805B2/en active Active
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2021
- 2021-03-26 AU AU2021201914A patent/AU2021201914A1/en active Pending
- 2021-07-23 US US17/383,550 patent/US20210346528A1/en active Pending
- 2021-07-23 US US17/383,567 patent/US20220008568A1/en active Pending
- 2021-07-23 US US17/383,577 patent/US20210346529A1/en active Pending
- 2021-09-22 JP JP2021154188A patent/JP7358430B2/ja active Active
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2023
- 2023-07-13 JP JP2023115231A patent/JP2023126440A/ja active Pending
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2024
- 2024-05-02 IL IL312551A patent/IL312551A/en unknown