JP2023116770A5 - - Google Patents
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- JP2023116770A5 JP2023116770A5 JP2023101375A JP2023101375A JP2023116770A5 JP 2023116770 A5 JP2023116770 A5 JP 2023116770A5 JP 2023101375 A JP2023101375 A JP 2023101375A JP 2023101375 A JP2023101375 A JP 2023101375A JP 2023116770 A5 JP2023116770 A5 JP 2023116770A5
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- JP
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- Prior art keywords
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- set forth
- amino acid
- interspersed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000035772 mutation Effects 0.000 claims 46
- 150000001413 amino acids Chemical class 0.000 claims 44
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 claims 9
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 claims 6
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 206010002022 amyloidosis Diseases 0.000 claims 2
- 230000019771 cognition Effects 0.000 claims 2
- 230000006999 cognitive decline Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 238000002405 diagnostic procedure Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 206010025421 Macule Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000005515 coenzyme Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- -1 radiolabels Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713996P | 2012-10-15 | 2012-10-15 | |
| US61/713,996 | 2012-10-15 | ||
| JP2020031419A JP6959377B2 (ja) | 2012-10-15 | 2020-02-27 | アミロイドβに対する抗体 |
| JP2021165338A JP7301924B2 (ja) | 2012-10-15 | 2021-10-07 | アミロイドβに対する抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021165338A Division JP7301924B2 (ja) | 2012-10-15 | 2021-10-07 | アミロイドβに対する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023116770A JP2023116770A (ja) | 2023-08-22 |
| JP2023116770A5 true JP2023116770A5 (https=) | 2024-01-18 |
Family
ID=49765450
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536189A Active JP6343615B2 (ja) | 2012-10-15 | 2013-10-15 | アミロイドβに対する抗体 |
| JP2018096788A Active JP6669805B2 (ja) | 2012-10-15 | 2018-05-21 | アミロイドβに対する抗体 |
| JP2020031419A Active JP6959377B2 (ja) | 2012-10-15 | 2020-02-27 | アミロイドβに対する抗体 |
| JP2021165338A Active JP7301924B2 (ja) | 2012-10-15 | 2021-10-07 | アミロイドβに対する抗体 |
| JP2023101375A Pending JP2023116770A (ja) | 2012-10-15 | 2023-06-21 | アミロイドβに対する抗体 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536189A Active JP6343615B2 (ja) | 2012-10-15 | 2013-10-15 | アミロイドβに対する抗体 |
| JP2018096788A Active JP6669805B2 (ja) | 2012-10-15 | 2018-05-21 | アミロイドβに対する抗体 |
| JP2020031419A Active JP6959377B2 (ja) | 2012-10-15 | 2020-02-27 | アミロイドβに対する抗体 |
| JP2021165338A Active JP7301924B2 (ja) | 2012-10-15 | 2021-10-07 | アミロイドβに対する抗体 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US9834598B2 (https=) |
| EP (2) | EP3721942A1 (https=) |
| JP (5) | JP6343615B2 (https=) |
| KR (2) | KR102308915B1 (https=) |
| CN (2) | CN105164156B (https=) |
| AU (3) | AU2013333948B2 (https=) |
| BR (1) | BR112015008347B1 (https=) |
| CA (1) | CA2888322A1 (https=) |
| CY (1) | CY1122987T1 (https=) |
| DK (1) | DK2906597T3 (https=) |
| ES (1) | ES2802873T3 (https=) |
| HR (1) | HRP20200936T1 (https=) |
| HU (1) | HUE051127T2 (https=) |
| LT (1) | LT2906597T (https=) |
| ME (1) | ME03751B (https=) |
| MX (2) | MX370725B (https=) |
| PL (1) | PL2906597T3 (https=) |
| PT (1) | PT2906597T (https=) |
| RS (1) | RS60388B1 (https=) |
| RU (2) | RU2689674C2 (https=) |
| SI (1) | SI2906597T1 (https=) |
| SM (1) | SMT202000340T1 (https=) |
| WO (1) | WO2014060444A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2689674C2 (ru) * | 2012-10-15 | 2019-05-28 | Медиммьюн Лимитед | Антитела к бета-амилоиду |
| WO2016120843A1 (en) * | 2015-01-29 | 2016-08-04 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, Sa | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders |
| JP6920293B2 (ja) | 2015-10-30 | 2021-08-18 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ＩｇＧ軽鎖におけるＮ末端切断の防止 |
| US20190262327A1 (en) | 2016-03-15 | 2019-08-29 | Astrazeneca Ab | Combination of a bace inhibitor and an antibody or antigen-binding fragment for the treatment of a disorder associated with the accumulation of amyloid beta |
| CA3026598A1 (en) * | 2016-06-07 | 2017-12-14 | Biogen International Neuroscience Gmbh | Methods for treating alzheimer's disease |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| CA3106116A1 (en) | 2018-07-17 | 2020-01-23 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-abeta antibody, antigen-binding fragment thereof and application thereof |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| WO2021011673A2 (en) * | 2019-07-16 | 2021-01-21 | Ming Jin | Neutralizing anti-amyloid beta antibodies for the treatment of alzheimer's disease |
| WO2021055670A1 (en) | 2019-09-20 | 2021-03-25 | Avx Corporation | Somatic cell-based electrical biosensor |
| CN111454980A (zh) * | 2020-04-14 | 2020-07-28 | 郑州师范学院 | 重组载体的构建方法及其构建的重组载体及应用 |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| IL299215A (en) * | 2020-06-25 | 2023-02-01 | Medimmune Ltd | Prevention of axonal damage through binding of an antibody to amyloid beta 1-42 |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| KR102565470B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 sma_04088-2 및 이를 포함하는 알츠하이머병 치료용 조성물 |
| KR102565471B1 (ko) * | 2022-08-04 | 2023-08-10 | 가천대학교 산학협력단 | 아밀로이드 베타 특이적 펩타이드 cbrv1-04369 및 이를 포함하는 알츠하이머병 치료용 조성물 |
| WO2024086796A1 (en) | 2022-10-20 | 2024-04-25 | Alector Llc | Anti-ms4a4a antibodies with amyloid-beta therapies |
| CN116716351B (zh) * | 2023-03-30 | 2024-02-23 | 湖北天勤生物技术研究院有限公司 | 用于构建食蟹猴阿尔兹海默症模型的组合物及其应用和构建方法 |
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| US565332A (en) | 1896-08-04 | Toy for making soap-bubbles | ||
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
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| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
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| WO2009085200A2 (en) * | 2007-12-21 | 2009-07-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
| US8298533B2 (en) * | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
| RU2689674C2 (ru) * | 2012-10-15 | 2019-05-28 | Медиммьюн Лимитед | Антитела к бета-амилоиду |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
| US20190262327A1 (en) | 2016-03-15 | 2019-08-29 | Astrazeneca Ab | Combination of a bace inhibitor and an antibody or antigen-binding fragment for the treatment of a disorder associated with the accumulation of amyloid beta |
| AR107783A1 (es) | 2016-03-15 | 2018-06-06 | Lilly Co Eli | Terapia de combinación |
-
2013
- 2013-10-15 RU RU2018110064A patent/RU2689674C2/ru active
- 2013-10-15 DK DK13805277.4T patent/DK2906597T3/da active
- 2013-10-15 HR HRP20200936TT patent/HRP20200936T1/hr unknown
- 2013-10-15 WO PCT/EP2013/071567 patent/WO2014060444A1/en not_active Ceased
- 2013-10-15 PL PL13805277T patent/PL2906597T3/pl unknown
- 2013-10-15 RU RU2015118180A patent/RU2651486C2/ru active
- 2013-10-15 EP EP20160286.9A patent/EP3721942A1/en active Pending
- 2013-10-15 CN CN201380053909.7A patent/CN105164156B/zh active Active
- 2013-10-15 EP EP13805277.4A patent/EP2906597B1/en active Active
- 2013-10-15 PT PT138052774T patent/PT2906597T/pt unknown
- 2013-10-15 LT LTEP13805277.4T patent/LT2906597T/lt unknown
- 2013-10-15 BR BR112015008347-1A patent/BR112015008347B1/pt active IP Right Grant
- 2013-10-15 CN CN201910295599.9A patent/CN110294804B/zh active Active
- 2013-10-15 CA CA2888322A patent/CA2888322A1/en active Pending
- 2013-10-15 US US14/435,520 patent/US9834598B2/en active Active
- 2013-10-15 AU AU2013333948A patent/AU2013333948B2/en active Active
- 2013-10-15 HU HUE13805277A patent/HUE051127T2/hu unknown
- 2013-10-15 ME MEP-2020-119A patent/ME03751B/me unknown
- 2013-10-15 RS RS20200694A patent/RS60388B1/sr unknown
- 2013-10-15 SM SM20200340T patent/SMT202000340T1/it unknown
- 2013-10-15 MX MX2015004763A patent/MX370725B/es active IP Right Grant
- 2013-10-15 KR KR1020157012631A patent/KR102308915B1/ko active Active
- 2013-10-15 ES ES13805277T patent/ES2802873T3/es active Active
- 2013-10-15 JP JP2015536189A patent/JP6343615B2/ja active Active
- 2013-10-15 KR KR1020217031163A patent/KR102450670B1/ko active Active
- 2013-10-15 SI SI201331737T patent/SI2906597T1/sl unknown
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2015
- 2015-04-15 MX MX2019015602A patent/MX2019015602A/es unknown
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2017
- 2017-10-25 US US15/793,510 patent/US10662239B2/en active Active
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2018
- 2018-05-21 JP JP2018096788A patent/JP6669805B2/ja active Active
- 2018-10-30 AU AU2018256498A patent/AU2018256498C1/en active Active
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2020
- 2020-02-27 JP JP2020031419A patent/JP6959377B2/ja active Active
- 2020-05-01 US US16/864,439 patent/US11286297B2/en active Active
- 2020-06-11 CY CY20201100538T patent/CY1122987T1/el unknown
- 2020-10-16 AU AU2020256414A patent/AU2020256414B2/en active Active
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2021
- 2021-10-07 JP JP2021165338A patent/JP7301924B2/ja active Active
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2022
- 2022-02-16 US US17/673,449 patent/US12098191B2/en active Active
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2023
- 2023-06-21 JP JP2023101375A patent/JP2023116770A/ja active Pending
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2024
- 2024-03-14 US US18/604,668 patent/US12344664B2/en active Active
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2025
- 2025-05-28 US US19/221,202 patent/US20250304670A1/en active Pending
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