JP2023062189A5 - - Google Patents
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- JP2023062189A5 JP2023062189A5 JP2023027585A JP2023027585A JP2023062189A5 JP 2023062189 A5 JP2023062189 A5 JP 2023062189A5 JP 2023027585 A JP2023027585 A JP 2023027585A JP 2023027585 A JP2023027585 A JP 2023027585A JP 2023062189 A5 JP2023062189 A5 JP 2023062189A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- solid pharmaceutical
- compound
- pharmaceutical formulation
- formulation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 239000007787 solid Substances 0.000 claims 25
- 229940125904 compound 1 Drugs 0.000 claims 17
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 10
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims 7
- 239000008199 coating composition Substances 0.000 claims 7
- 229960001021 lactose monohydrate Drugs 0.000 claims 7
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 7
- 229940079832 sodium starch glycolate Drugs 0.000 claims 7
- 239000008109 sodium starch glycolate Substances 0.000 claims 7
- 229920003109 sodium starch glycolate Polymers 0.000 claims 7
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 5
- 235000019359 magnesium stearate Nutrition 0.000 claims 5
- NSQSAUGJQHDYNO-UHFFFAOYSA-N n-[(4,6-dimethyl-2-oxo-1h-pyridin-3-yl)methyl]-3-[ethyl(oxan-4-yl)amino]-2-methyl-5-[4-(morpholin-4-ylmethyl)phenyl]benzamide Chemical compound C=1C(C=2C=CC(CN3CCOCC3)=CC=2)=CC(C(=O)NCC=2C(NC(C)=CC=2C)=O)=C(C)C=1N(CC)C1CCOCC1 NSQSAUGJQHDYNO-UHFFFAOYSA-N 0.000 claims 5
- 206010025323 Lymphomas Diseases 0.000 claims 4
- 239000007884 disintegrant Substances 0.000 claims 4
- 201000003444 follicular lymphoma Diseases 0.000 claims 4
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 claims 3
- 206010036711 Primary mediastinal large B-cell lymphomas Diseases 0.000 claims 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007888 film coating Substances 0.000 claims 1
- 238000009501 film coating Methods 0.000 claims 1
- 210000001280 germinal center Anatomy 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229960003943 hypromellose Drugs 0.000 claims 1
- LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 claims 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 1
- 229960003511 macrogol Drugs 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 229940033134 talc Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000004408 titanium dioxide Substances 0.000 claims 1
- 229960005196 titanium dioxide Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080985P | 2014-11-17 | 2014-11-17 | |
| US62/080,985 | 2014-11-17 | ||
| US201562166572P | 2015-05-26 | 2015-05-26 | |
| US62/166,572 | 2015-05-26 | ||
| US201562251903P | 2015-11-06 | 2015-11-06 | |
| US62/251,903 | 2015-11-06 | ||
| JP2021008382A JP2021073241A (ja) | 2014-11-17 | 2021-01-22 | 癌を処置する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021008382A Division JP2021073241A (ja) | 2014-11-17 | 2021-01-22 | 癌を処置する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023062189A JP2023062189A (ja) | 2023-05-02 |
| JP2023062189A5 true JP2023062189A5 (https=) | 2024-01-25 |
| JP7485810B2 JP7485810B2 (ja) | 2024-05-16 |
Family
ID=56014476
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526088A Active JP6829684B2 (ja) | 2014-11-17 | 2015-11-17 | 癌を処置する方法 |
| JP2021008382A Pending JP2021073241A (ja) | 2014-11-17 | 2021-01-22 | 癌を処置する方法 |
| JP2023027585A Active JP7485810B2 (ja) | 2014-11-17 | 2023-02-24 | 癌を処置する方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526088A Active JP6829684B2 (ja) | 2014-11-17 | 2015-11-17 | 癌を処置する方法 |
| JP2021008382A Pending JP2021073241A (ja) | 2014-11-17 | 2021-01-22 | 癌を処置する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10786511B2 (https=) |
| EP (2) | EP3220916B1 (https=) |
| JP (3) | JP6829684B2 (https=) |
| KR (3) | KR20240035908A (https=) |
| CN (2) | CN107249591B (https=) |
| AU (3) | AU2015350108B2 (https=) |
| BR (1) | BR112017010166A2 (https=) |
| DK (1) | DK3220916T3 (https=) |
| EA (1) | EA201791095A1 (https=) |
| ES (1) | ES2947819T3 (https=) |
| FI (1) | FI3220916T3 (https=) |
| HU (1) | HUE062159T2 (https=) |
| IL (4) | IL304252B2 (https=) |
| LT (1) | LT3220916T (https=) |
| MX (2) | MX383484B (https=) |
| PL (1) | PL3220916T3 (https=) |
| PT (1) | PT3220916T (https=) |
| SG (1) | SG11201703806XA (https=) |
| SI (1) | SI3220916T1 (https=) |
| WO (1) | WO2016081523A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3363B1 (ar) | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| KR20230156450A (ko) | 2012-10-15 | 2023-11-14 | 에피자임, 인코포레이티드 | 암을 치료하는 방법 |
| CN116019921A (zh) | 2013-12-06 | 2023-04-28 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| BR112016029492A2 (pt) | 2014-06-17 | 2017-10-17 | Eisai R&D Man Co Ltd | método para tratamento de linfoma não hodgkin |
| HUE062159T2 (hu) | 2014-11-17 | 2023-10-28 | Epizyme Inc | Módszer a rák kezelésére N-((4,6-dimetil-2-oxo-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H -pirán-4-il)amino)-4-metil-4'-(morfolinmetil)-[1,1'-bifenil]-3-karboxamiddal |
| WO2016172199A1 (en) | 2015-04-20 | 2016-10-27 | Epizyme, Inc. | Combination therapy for treating cancer |
| AU2016275051A1 (en) | 2015-06-10 | 2017-12-07 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
| WO2017035234A1 (en) | 2015-08-24 | 2017-03-02 | Epizyme, Inc. | Method for treating cancer |
| EP3407978A4 (en) | 2016-01-29 | 2020-01-15 | Epizyme Inc | POLYTHERAPY FOR THE TREATMENT OF CANCER |
| CA3025933A1 (en) | 2016-06-01 | 2017-12-07 | Epizyme, Inc. | Use of ezh2 inhibitors for treating cancer |
| WO2017218953A1 (en) | 2016-06-17 | 2017-12-21 | Epizyme, Inc. | Ezh2 inhibitors for treating cancer |
| JP7125353B2 (ja) | 2017-01-19 | 2022-08-24 | 第一三共株式会社 | Ｈｔｌｖ－１関連脊髄症を治療することに用いるための医薬組成物 |
| WO2018183885A1 (en) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Combination therapy for treating cancer |
| AU2018275123A1 (en) | 2017-06-02 | 2020-01-30 | Epizyme, Inc. | Use of EZH2 inhibitors for treating cancer |
| CN111093660A (zh) | 2017-09-05 | 2020-05-01 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| IL294108A (en) * | 2019-12-20 | 2022-08-01 | Epizyme Inc | Crystalline hydrobromide salt of a ezh2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer |
| JP7628876B2 (ja) | 2021-04-23 | 2025-02-12 | 日立Astemo株式会社 | 情報処理装置、情報処理方法、プログラムおよび記憶媒体 |
| WO2023159124A2 (en) * | 2022-02-17 | 2023-08-24 | Memorial Sloan-Kettering Cancer Center | Methods for overcoming tazemetostat-resistance in cancer patients |
| TW202400140A (zh) | 2022-04-27 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與ezh1及/或ezh2抑制劑之組合 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119052D0 (en) | 1991-09-06 | 1991-10-23 | Boots Co Plc | Pharmaceutical compositions |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US20070026064A1 (en) * | 2005-07-29 | 2007-02-01 | Yoder Steven L | Pharmaceutical dosage forms having watermark-type identification and authentication inditia |
| WO2008121476A1 (en) * | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20100278921A1 (en) * | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
| US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
| BR112013005806B1 (pt) | 2010-09-10 | 2022-05-10 | Epizyme, Inc | Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2 |
| EP2663283B1 (en) * | 2011-01-14 | 2017-05-10 | Bristol-Myers Squibb Company | High drug load tablet formulation of brivanib alaninate |
| ES2951688T3 (es) | 2011-02-28 | 2023-10-24 | Epizyme Inc | Compuestos de heteroarilo biciclico fusionados en 6,5 sustituidos |
| JO3363B1 (ar) | 2011-04-13 | 2019-03-13 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
| TWI598336B (zh) | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
| EP3536314A1 (en) * | 2012-03-12 | 2019-09-11 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
| PT3184523T (pt) | 2012-04-13 | 2019-09-26 | Eisai R&D Man Co Ltd | Bromidrato de n-((4,6-dimetil-2-oxo-l,2-di-hidropiridin- 3-il)metil)-5-(etil(tetra-hidro-2h-piran-4-il)amino)-4- metil-4¿-(morfolinometil)-[l,1¿-bofenil]-3-carboxamida para utilização no tratamento de uma doença proliferativa celular do sistema hematológico |
| SG10201912111TA (en) * | 2012-04-13 | 2020-02-27 | Epizyme Inc | Combination therapy for treating cancer |
| MX2015004721A (es) | 2012-10-15 | 2016-01-25 | Epizyme Inc | Compuestos de benceno sustituidos. |
| KR20230156450A (ko) * | 2012-10-15 | 2023-11-14 | 에피자임, 인코포레이티드 | 암을 치료하는 방법 |
| EP2934531A4 (en) * | 2012-12-19 | 2016-06-15 | Glaxosmithkline Llc | COMBINATION |
| AU2013361060B2 (en) | 2012-12-21 | 2018-04-19 | Epizyme, Inc. | 1,4-pyridone compounds |
| CA2894222A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone bicyclic heteroaryl compounds |
| US9776996B2 (en) | 2013-03-15 | 2017-10-03 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| CA2903572A1 (en) | 2013-03-15 | 2014-10-23 | Epizyme, Inc. | Substituted benzene compounds |
| US10150764B2 (en) | 2013-07-19 | 2018-12-11 | Epizyme, Inc. | Substituted benzene compounds |
| MA38949A1 (fr) * | 2013-10-16 | 2017-07-31 | Eisai R&D Man Co Ltd | Forme saline d'hydrochlorure pour inhibition d'ezh2 |
| WO2015058125A1 (en) | 2013-10-18 | 2015-04-23 | Epizyme, Inc. | Method of treating cancer |
| CN116019921A (zh) | 2013-12-06 | 2023-04-28 | Epizyme股份有限公司 | 用于治疗癌症的组合疗法 |
| BR112016029492A2 (pt) * | 2014-06-17 | 2017-10-17 | Eisai R&D Man Co Ltd | método para tratamento de linfoma não hodgkin |
| WO2015200650A1 (en) | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Substituted benzene and 6,5-fused bicyclic heteroaryl compounds |
| EA201790845A1 (ru) | 2014-10-16 | 2017-08-31 | Эпизайм, Инк. | Способ лечения рака |
| HUE062159T2 (hu) | 2014-11-17 | 2023-10-28 | Epizyme Inc | Módszer a rák kezelésére N-((4,6-dimetil-2-oxo-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H -pirán-4-il)amino)-4-metil-4'-(morfolinmetil)-[1,1'-bifenil]-3-karboxamiddal |
| AU2016275051A1 (en) * | 2015-06-10 | 2017-12-07 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
| WO2017218953A1 (en) * | 2016-06-17 | 2017-12-21 | Epizyme, Inc. | Ezh2 inhibitors for treating cancer |
-
2015
- 2015-11-17 HU HUE15860676A patent/HUE062159T2/hu unknown
- 2015-11-17 US US15/527,375 patent/US10786511B2/en active Active
- 2015-11-17 KR KR1020247007271A patent/KR20240035908A/ko active Pending
- 2015-11-17 LT LTEPPCT/US2015/061194T patent/LT3220916T/lt unknown
- 2015-11-17 EP EP15860676.4A patent/EP3220916B1/en active Active
- 2015-11-17 PL PL15860676.4T patent/PL3220916T3/pl unknown
- 2015-11-17 JP JP2017526088A patent/JP6829684B2/ja active Active
- 2015-11-17 EP EP23168326.9A patent/EP4272742A1/en active Pending
- 2015-11-17 BR BR112017010166-1A patent/BR112017010166A2/en not_active Application Discontinuation
- 2015-11-17 FI FIEP15860676.4T patent/FI3220916T3/fi active
- 2015-11-17 WO PCT/US2015/061194 patent/WO2016081523A1/en not_active Ceased
- 2015-11-17 KR KR1020217040314A patent/KR102644844B1/ko active Active
- 2015-11-17 PT PT158606764T patent/PT3220916T/pt unknown
- 2015-11-17 MX MX2017006089A patent/MX383484B/es unknown
- 2015-11-17 CN CN201580063476.2A patent/CN107249591B/zh active Active
- 2015-11-17 KR KR1020177016377A patent/KR102338802B1/ko active Active
- 2015-11-17 EA EA201791095A patent/EA201791095A1/ru unknown
- 2015-11-17 AU AU2015350108A patent/AU2015350108B2/en active Active
- 2015-11-17 IL IL304252A patent/IL304252B2/en unknown
- 2015-11-17 DK DK15860676.4T patent/DK3220916T3/da active
- 2015-11-17 IL IL296080A patent/IL296080B2/en unknown
- 2015-11-17 CN CN202310518396.8A patent/CN116650500B/zh active Active
- 2015-11-17 ES ES15860676T patent/ES2947819T3/es active Active
- 2015-11-17 SG SG11201703806XA patent/SG11201703806XA/en unknown
- 2015-11-17 SI SI201531949T patent/SI3220916T1/sl unknown
-
2017
- 2017-05-09 IL IL252182A patent/IL252182B2/en unknown
- 2017-05-09 MX MX2021006734A patent/MX2021006734A/es unknown
-
2020
- 2020-08-20 US US16/998,144 patent/US12168014B2/en active Active
-
2021
- 2021-01-22 JP JP2021008382A patent/JP2021073241A/ja active Pending
- 2021-07-06 AU AU2021204706A patent/AU2021204706B2/en active Active
-
2023
- 2023-02-24 JP JP2023027585A patent/JP7485810B2/ja active Active
-
2024
- 2024-02-22 AU AU2024201171A patent/AU2024201171B2/en active Active
- 2024-11-08 US US18/941,480 patent/US20250064822A1/en active Pending
-
2025
- 2025-09-16 IL IL323396A patent/IL323396A/en unknown
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