KR20240035908A - 암을 치료하기 위한 방법 - Google Patents

암을 치료하기 위한 방법 Download PDF

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Publication number
KR20240035908A
KR20240035908A KR1020247007271A KR20247007271A KR20240035908A KR 20240035908 A KR20240035908 A KR 20240035908A KR 1020247007271 A KR1020247007271 A KR 1020247007271A KR 20247007271 A KR20247007271 A KR 20247007271A KR 20240035908 A KR20240035908 A KR 20240035908A
Authority
KR
South Korea
Prior art keywords
effective amount
therapeutically effective
dosage form
epz
dissolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247007271A
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English (en)
Korean (ko)
Inventor
헤이케 케일해크
브렛 트루잇
유타 스즈키
츠카사 무라세
후토시 시카타
Original Assignee
에피자임, 인코포레이티드
에자이 알앤드디 매니지먼트 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에피자임, 인코포레이티드, 에자이 알앤드디 매니지먼트 가부시키가이샤 filed Critical 에피자임, 인코포레이티드
Publication of KR20240035908A publication Critical patent/KR20240035908A/ko
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
KR1020247007271A 2014-11-17 2015-11-17 암을 치료하기 위한 방법 Pending KR20240035908A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201462080985P 2014-11-17 2014-11-17
US62/080,985 2014-11-17
US201562166572P 2015-05-26 2015-05-26
US62/166,572 2015-05-26
US201562251903P 2015-11-06 2015-11-06
US62/251,903 2015-11-06
KR1020217040314A KR102644844B1 (ko) 2014-11-17 2015-11-17 암을 치료하기 위한 방법
PCT/US2015/061194 WO2016081523A1 (en) 2014-11-17 2015-11-17 Method for treating cancer

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217040314A Division KR102644844B1 (ko) 2014-11-17 2015-11-17 암을 치료하기 위한 방법

Publications (1)

Publication Number Publication Date
KR20240035908A true KR20240035908A (ko) 2024-03-18

Family

ID=56014476

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020247007271A Pending KR20240035908A (ko) 2014-11-17 2015-11-17 암을 치료하기 위한 방법
KR1020217040314A Active KR102644844B1 (ko) 2014-11-17 2015-11-17 암을 치료하기 위한 방법
KR1020177016377A Active KR102338802B1 (ko) 2014-11-17 2015-11-17 암을 치료하기 위한 방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020217040314A Active KR102644844B1 (ko) 2014-11-17 2015-11-17 암을 치료하기 위한 방법
KR1020177016377A Active KR102338802B1 (ko) 2014-11-17 2015-11-17 암을 치료하기 위한 방법

Country Status (20)

Country Link
US (3) US10786511B2 (https=)
EP (2) EP3220916B1 (https=)
JP (3) JP6829684B2 (https=)
KR (3) KR20240035908A (https=)
CN (2) CN107249591B (https=)
AU (3) AU2015350108B2 (https=)
BR (1) BR112017010166A2 (https=)
DK (1) DK3220916T3 (https=)
EA (1) EA201791095A1 (https=)
ES (1) ES2947819T3 (https=)
FI (1) FI3220916T3 (https=)
HU (1) HUE062159T2 (https=)
IL (4) IL304252B2 (https=)
LT (1) LT3220916T (https=)
MX (2) MX383484B (https=)
PL (1) PL3220916T3 (https=)
PT (1) PT3220916T (https=)
SG (1) SG11201703806XA (https=)
SI (1) SI3220916T1 (https=)
WO (1) WO2016081523A1 (https=)

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CN116019921A (zh) 2013-12-06 2023-04-28 Epizyme股份有限公司 用于治疗癌症的组合疗法
BR112016029492A2 (pt) 2014-06-17 2017-10-17 Eisai R&D Man Co Ltd método para tratamento de linfoma não hodgkin
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WO2017035234A1 (en) 2015-08-24 2017-03-02 Epizyme, Inc. Method for treating cancer
EP3407978A4 (en) 2016-01-29 2020-01-15 Epizyme Inc POLYTHERAPY FOR THE TREATMENT OF CANCER
CA3025933A1 (en) 2016-06-01 2017-12-07 Epizyme, Inc. Use of ezh2 inhibitors for treating cancer
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JP7125353B2 (ja) 2017-01-19 2022-08-24 第一三共株式会社 Ｈｔｌｖ－１関連脊髄症を治療することに用いるための医薬組成物
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Also Published As

Publication number Publication date
EP4272742A1 (en) 2023-11-08
EP3220916B1 (en) 2023-04-19
ES2947819T3 (es) 2023-08-21
PL3220916T3 (pl) 2023-08-14
KR20170103768A (ko) 2017-09-13
JP2023062189A (ja) 2023-05-02
JP2021073241A (ja) 2021-05-13
JP2017537899A (ja) 2017-12-21
FI3220916T3 (fi) 2023-06-19
IL304252B1 (en) 2025-11-01
JP7485810B2 (ja) 2024-05-16
IL296080B1 (en) 2023-08-01
CN107249591B (zh) 2024-01-30
AU2021204706B2 (en) 2023-11-23
IL252182A0 (en) 2017-07-31
IL304252A (en) 2023-09-01
JP6829684B2 (ja) 2021-02-10
EP3220916A1 (en) 2017-09-27
IL304252B2 (en) 2026-03-01
US20210060030A1 (en) 2021-03-04
IL296080A (en) 2022-11-01
IL323396A (en) 2025-11-01
WO2016081523A1 (en) 2016-05-26
PT3220916T (pt) 2023-06-26
CN116650500A (zh) 2023-08-29
AU2015350108A1 (en) 2017-05-25
MX2021006734A (es) 2021-07-02
AU2024201171B2 (en) 2026-01-29
US10786511B2 (en) 2020-09-29
NZ768247A (en) 2024-05-31
AU2021204706A1 (en) 2021-07-29
KR20210156840A (ko) 2021-12-27
AU2015350108B2 (en) 2021-04-08
SI3220916T1 (sl) 2023-09-29
BR112017010166A2 (en) 2018-02-14
NZ731696A (en) 2024-03-22
CN116650500B (zh) 2026-03-06
EP3220916A4 (en) 2018-07-11
US20170360797A1 (en) 2017-12-21
AU2024201171A1 (en) 2024-03-14
EA201791095A1 (ru) 2017-10-31
MX383484B (es) 2025-03-11
US20250064822A1 (en) 2025-02-27
US12168014B2 (en) 2024-12-17
IL252182B2 (en) 2023-02-01
LT3220916T (lt) 2023-07-25
CA2967664A1 (en) 2016-05-26
KR102644844B1 (ko) 2024-03-07
MX2017006089A (es) 2017-12-11
IL296080B2 (en) 2023-12-01
CN107249591A (zh) 2017-10-13
KR102338802B1 (ko) 2021-12-14
DK3220916T3 (da) 2023-06-26
HUE062159T2 (hu) 2023-10-28
SG11201703806XA (en) 2017-06-29
IL252182B (en) 2022-10-01

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