JP2022553077A5 - - Google Patents
Info
- Publication number
- JP2022553077A5 JP2022553077A5 JP2022523855A JP2022523855A JP2022553077A5 JP 2022553077 A5 JP2022553077 A5 JP 2022553077A5 JP 2022523855 A JP2022523855 A JP 2022523855A JP 2022523855 A JP2022523855 A JP 2022523855A JP 2022553077 A5 JP2022553077 A5 JP 2022553077A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- halo
- phenyl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962923936P | 2019-10-21 | 2019-10-21 | |
| US62/923,936 | 2019-10-21 | ||
| PCT/IB2020/001135 WO2021079196A2 (en) | 2019-10-21 | 2020-10-20 | Mettl3 modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022553077A JP2022553077A (ja) | 2022-12-21 |
| JP2022553077A5 true JP2022553077A5 (https=) | 2023-10-30 |
Family
ID=73856560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022523855A Pending JP2022553077A (ja) | 2019-10-21 | 2020-10-20 | Ｍｅｔｔｌ３モジュレーター |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230027361A1 (https=) |
| EP (1) | EP4048674A2 (https=) |
| JP (1) | JP2022553077A (https=) |
| CN (1) | CN115298179A (https=) |
| AU (1) | AU2020372002A1 (https=) |
| WO (1) | WO2021079196A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022074391A1 (en) * | 2020-10-08 | 2022-04-14 | Storm Therapeutics Limited | Compounds inhibitors of mettl3 |
| CN113234079B (zh) * | 2021-04-30 | 2022-02-01 | 上海湃隆生物科技有限公司 | 用作prmt5抑制剂的核苷类似物 |
| CN114032311A (zh) * | 2021-12-24 | 2022-02-11 | 山东大学齐鲁医院 | Mettl3在aml化疗耐药性中的应用 |
| CN118660890A (zh) * | 2022-02-11 | 2024-09-17 | 西藏海思科制药有限公司 | 一种mettl3抑制剂及组合物及其在医药上的应用 |
| CN115850280B (zh) * | 2022-12-08 | 2024-07-05 | 南京康立瑞生物科技有限公司 | 一种抗病毒药恩替卡韦中间体n4的制备方法 |
| CN120731203A (zh) | 2023-01-20 | 2025-09-30 | 艾匹克治疗公司 | 作为mettl3抑制剂的哌啶衍生物 |
| AU2024244637A1 (en) | 2023-03-30 | 2025-10-16 | Aqemia | Novel mettl3 inhibitors and use thereof in therapy |
| WO2025049624A1 (en) * | 2023-08-29 | 2025-03-06 | Purdue Research Foundation | Prodrugs of nicotinamide n-methyltransferase (nnmt) inhibitors and uses thereof |
| WO2025106014A1 (en) * | 2023-11-14 | 2025-05-22 | Engine Biosciences Pte. Ltd. | Compounds and methods for pkmyt1 inhibition |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI870767B (zh) * | 2015-08-26 | 2025-01-21 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
| WO2018065365A1 (en) * | 2016-10-03 | 2018-04-12 | Janssen Pharmaceutica Nv | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors |
| EP3939986A1 (en) * | 2017-08-09 | 2022-01-19 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (prmt5) |
| JP2021505583A (ja) * | 2017-12-05 | 2021-02-18 | エンジェクス ファーマシューティカル インコーポレイテッド | Ｐｍｒｔ５阻害剤としての複素環式化合物 |
| MA55556A (fr) * | 2019-04-02 | 2022-02-09 | Aligos Therapeutics Inc | Composés ciblant prmt5 |
-
2020
- 2020-10-20 EP EP20862016.1A patent/EP4048674A2/en not_active Withdrawn
- 2020-10-20 US US17/770,708 patent/US20230027361A1/en not_active Abandoned
- 2020-10-20 AU AU2020372002A patent/AU2020372002A1/en not_active Abandoned
- 2020-10-20 WO PCT/IB2020/001135 patent/WO2021079196A2/en not_active Ceased
- 2020-10-20 CN CN202080088790.7A patent/CN115298179A/zh active Pending
- 2020-10-20 JP JP2022523855A patent/JP2022553077A/ja active Pending
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