JP2022553077A - Ｍｅｔｔｌ３モジュレーター - Google Patents

Ｍｅｔｔｌ３モジュレーター Download PDF

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Publication number
JP2022553077A
JP2022553077A JP2022523855A JP2022523855A JP2022553077A JP 2022553077 A JP2022553077 A JP 2022553077A JP 2022523855 A JP2022523855 A JP 2022523855A JP 2022523855 A JP2022523855 A JP 2022523855A JP 2022553077 A JP2022553077 A JP 2022553077A
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JP
Japan
Prior art keywords
alkyl
cycloalkyl
halo
membered
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022523855A
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English (en)
Japanese (ja)
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JP2022553077A5 (https=
Inventor
トーマス・アンドリュー・ウィン
ブライアン・ルイス・ホダウス
ポーラ・アン・ボリアック－ショーディン
アーネスト・アレン・シックミアー
ジェームス・エドワード・ジョン・ミルズ
ロバート・エイ・コープランド
ブライアン・アンドリュー・スパーリング
マシュー・エイチ・ダニエルズ
アンドリュー・スチュアート・タスカー
ケネス・ダブリュ・ダンカン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Accent Therapeutics Inc
Original Assignee
Accent Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Accent Therapeutics Inc filed Critical Accent Therapeutics Inc
Publication of JP2022553077A publication Critical patent/JP2022553077A/ja
Publication of JP2022553077A5 publication Critical patent/JP2022553077A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
JP2022523855A 2019-10-21 2020-10-20 Ｍｅｔｔｌ３モジュレーター Pending JP2022553077A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962923936P 2019-10-21 2019-10-21
US62/923,936 2019-10-21
PCT/IB2020/001135 WO2021079196A2 (en) 2019-10-21 2020-10-20 Mettl3 modulators

Publications (2)

Publication Number Publication Date
JP2022553077A true JP2022553077A (ja) 2022-12-21
JP2022553077A5 JP2022553077A5 (https=) 2023-10-30

Family

ID=73856560

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022523855A Pending JP2022553077A (ja) 2019-10-21 2020-10-20 Ｍｅｔｔｌ３モジュレーター

Country Status (6)

Country Link
US (1) US20230027361A1 (https=)
EP (1) EP4048674A2 (https=)
JP (1) JP2022553077A (https=)
CN (1) CN115298179A (https=)
AU (1) AU2020372002A1 (https=)
WO (1) WO2021079196A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022074391A1 (en) * 2020-10-08 2022-04-14 Storm Therapeutics Limited Compounds inhibitors of mettl3
CN113234079B (zh) * 2021-04-30 2022-02-01 上海湃隆生物科技有限公司 用作prmt5抑制剂的核苷类似物
CN114032311A (zh) * 2021-12-24 2022-02-11 山东大学齐鲁医院 Mettl3在aml化疗耐药性中的应用
CN118660890A (zh) * 2022-02-11 2024-09-17 西藏海思科制药有限公司 一种mettl3抑制剂及组合物及其在医药上的应用
CN115850280B (zh) * 2022-12-08 2024-07-05 南京康立瑞生物科技有限公司 一种抗病毒药恩替卡韦中间体n4的制备方法
CN120731203A (zh) 2023-01-20 2025-09-30 艾匹克治疗公司 作为mettl3抑制剂的哌啶衍生物
AU2024244637A1 (en) 2023-03-30 2025-10-16 Aqemia Novel mettl3 inhibitors and use thereof in therapy
WO2025049624A1 (en) * 2023-08-29 2025-03-06 Purdue Research Foundation Prodrugs of nicotinamide n-methyltransferase (nnmt) inhibitors and uses thereof
WO2025106014A1 (en) * 2023-11-14 2025-05-22 Engine Biosciences Pte. Ltd. Compounds and methods for pkmyt1 inhibition

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018065365A1 (en) * 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors
JP2018528946A (ja) * 2015-08-26 2018-10-04 ヤンセン ファーマシューティカ エヌ．ベー． Ｐｒｍｔ５阻害剤として使用するための新規な６−６二環式芳香環置換ヌクレオシド類似体
WO2019032859A1 (en) * 2017-08-09 2019-02-14 Prelude Therapeutics, Incorporated SELECTIVE INHIBITORS OF THE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)
WO2019112719A1 (en) * 2017-12-05 2019-06-13 Angex Pharmaceutical, Inc. Heterocyclic compounds as prmt5 inhibitors
WO2020205867A1 (en) * 2019-04-02 2020-10-08 Aligos Therapeutics, Inc. Compounds targeting prmt5

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018528946A (ja) * 2015-08-26 2018-10-04 ヤンセン ファーマシューティカ エヌ．ベー． Ｐｒｍｔ５阻害剤として使用するための新規な６−６二環式芳香環置換ヌクレオシド類似体
WO2018065365A1 (en) * 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors
WO2019032859A1 (en) * 2017-08-09 2019-02-14 Prelude Therapeutics, Incorporated SELECTIVE INHIBITORS OF THE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)
WO2019112719A1 (en) * 2017-12-05 2019-06-13 Angex Pharmaceutical, Inc. Heterocyclic compounds as prmt5 inhibitors
WO2020205867A1 (en) * 2019-04-02 2020-10-08 Aligos Therapeutics, Inc. Compounds targeting prmt5

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"CAS REGISTRY No．2086772-11-2，2086772-09-8，2086770-91-2", DATABASE REGISTRY, JPN7024003871, 2017, pages 2024 - 8, ISSN: 0005416632 *

Also Published As

Publication number Publication date
CN115298179A (zh) 2022-11-04
WO2021079196A3 (en) 2021-07-01
US20230027361A1 (en) 2023-01-26
WO2021079196A2 (en) 2021-04-29
WO2021079196A9 (en) 2022-07-14
EP4048674A2 (en) 2022-08-31
AU2020372002A1 (en) 2022-05-26

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