JP2022535290A5 - - Google Patents
Info
- Publication number
- JP2022535290A5 JP2022535290A5 JP2021572425A JP2021572425A JP2022535290A5 JP 2022535290 A5 JP2022535290 A5 JP 2022535290A5 JP 2021572425 A JP2021572425 A JP 2021572425A JP 2021572425 A JP2021572425 A JP 2021572425A JP 2022535290 A5 JP2022535290 A5 JP 2022535290A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridine
- oxadiazole
- trifluoromethyl
- pyrrolo
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19382475 | 2019-06-06 | ||
| EP19382475.2 | 2019-06-06 | ||
| EP19383221 | 2019-12-31 | ||
| EP19383221.9 | 2019-12-31 | ||
| PCT/EP2020/065658 WO2020245381A1 (en) | 2019-06-06 | 2020-06-05 | 3-(2-(heteroaryl)-pyridin-4-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole derivatives as hdac6 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022535290A JP2022535290A (ja) | 2022-08-05 |
| JP2022535290A5 true JP2022535290A5 (enExample) | 2023-06-13 |
| JP7523146B2 JP7523146B2 (ja) | 2024-07-26 |
Family
ID=71083614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021572425A Active JP7523146B2 (ja) | 2019-06-06 | 2020-06-05 | Ｈｄａｃ６阻害薬としての３－（２－（ヘテロアリール）－ピリジン－４－イル）－５－（トリフルオロメチル）－１，２，４－オキサジアゾール誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12522598B2 (enExample) |
| EP (2) | EP4789722A2 (enExample) |
| JP (1) | JP7523146B2 (enExample) |
| CN (1) | CN114206868B (enExample) |
| CA (1) | CA3142435A1 (enExample) |
| DK (1) | DK3980416T3 (enExample) |
| FI (1) | FI3980416T3 (enExample) |
| HR (1) | HRP20260656T1 (enExample) |
| LT (1) | LT3980416T (enExample) |
| MX (1) | MX2021014918A (enExample) |
| RS (1) | RS68111B1 (enExample) |
| SI (1) | SI3980416T1 (enExample) |
| WO (1) | WO2020245381A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| MX2020005841A (es) | 2017-12-05 | 2020-09-07 | Oryzon Genomics Sa | Derivados de 1,2,4-oxadiazol como inhibidores de histona-desacetilasa 6. |
| CN114727974A (zh) | 2019-07-30 | 2022-07-08 | 艾科尼佐治疗股份有限公司 | Hdac6抑制剂及其用途 |
| WO2022169985A1 (en) | 2021-02-03 | 2022-08-11 | Eikonizo Therapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| AU2023250964A1 (en) | 2022-04-08 | 2024-11-07 | Eikonizo Therapeutics, Inc. | Oxadiazole hdac6 inhibitors and uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8101618B2 (en) | 2005-04-06 | 2012-01-24 | Msd K.K. | 1,4-substituted piperazine derivatives |
| US20100136024A1 (en) | 2008-11-14 | 2010-06-03 | Bartels Stephen P | Selective Inhibition of Histone Deacetylase 6 for Ocular Neuroprotection or for Treatment or Control of Glaucoma |
| NZ610225A (en) | 2010-11-16 | 2015-08-28 | Acetylon Pharmaceuticals Inc | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
| WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| CA2856334A1 (en) | 2011-11-28 | 2013-06-06 | Christina Hebach | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| EP3187497A4 (en) | 2014-08-26 | 2018-02-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US10357484B2 (en) | 2015-07-17 | 2019-07-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN108026088B (zh) | 2015-07-17 | 2021-02-12 | 武田药品工业株式会社 | 用作hdac抑制剂的噁二唑衍生物 |
| WO2017033946A1 (ja) | 2015-08-25 | 2017-03-02 | 武田薬品工業株式会社 | 複素環化合物 |
| JP6970680B2 (ja) | 2016-03-15 | 2021-11-24 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| WO2017222952A1 (en) | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| WO2017222950A1 (en) * | 2016-06-23 | 2017-12-28 | Merck Sharp & Dohme Corp. | 3-heterocyclyl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| EP3475275B1 (en) * | 2016-06-23 | 2024-04-10 | Merck Sharp & Dohme LLC | 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
| WO2018118781A1 (en) | 2016-12-20 | 2018-06-28 | Fmc Corporation | Fungicidal oxadiazoles |
| MX2020005841A (es) | 2017-12-05 | 2020-09-07 | Oryzon Genomics Sa | Derivados de 1,2,4-oxadiazol como inhibidores de histona-desacetilasa 6. |
-
2020
- 2020-06-05 CN CN202080055779.0A patent/CN114206868B/zh active Active
- 2020-06-05 EP EP26163646.8A patent/EP4789722A2/en active Pending
- 2020-06-05 EP EP20732166.2A patent/EP3980416B1/en active Active
- 2020-06-05 HR HRP20260656TT patent/HRP20260656T1/hr unknown
- 2020-06-05 MX MX2021014918A patent/MX2021014918A/es unknown
- 2020-06-05 WO PCT/EP2020/065658 patent/WO2020245381A1/en not_active Ceased
- 2020-06-05 CA CA3142435A patent/CA3142435A1/en active Pending
- 2020-06-05 FI FIEP20732166.2T patent/FI3980416T3/fi active
- 2020-06-05 SI SI202030773T patent/SI3980416T1/sl unknown
- 2020-06-05 DK DK20732166.2T patent/DK3980416T3/da active
- 2020-06-05 RS RS20260600A patent/RS68111B1/sr unknown
- 2020-06-05 LT LTEPPCT/EP2020/065658T patent/LT3980416T/lt unknown
- 2020-06-05 US US17/596,048 patent/US12522598B2/en active Active
- 2020-06-05 JP JP2021572425A patent/JP7523146B2/ja active Active
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