JP2022526604A5 - - Google Patents

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Publication number
JP2022526604A5
JP2022526604A5 JP2021559255A JP2021559255A JP2022526604A5 JP 2022526604 A5 JP2022526604 A5 JP 2022526604A5 JP 2021559255 A JP2021559255 A JP 2021559255A JP 2021559255 A JP2021559255 A JP 2021559255A JP 2022526604 A5 JP2022526604 A5 JP 2022526604A5
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JP
Japan
Prior art keywords
product according
pharmaceutical product
alkyl
cr9r9
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021559255A
Other languages
English (en)
Japanese (ja)
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JP2022526604A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/026639 external-priority patent/WO2020206299A1/en
Publication of JP2022526604A publication Critical patent/JP2022526604A/ja
Publication of JP2022526604A5 publication Critical patent/JP2022526604A5/ja
Pending legal-status Critical Current

Links

JP2021559255A 2019-04-05 2020-04-03 タンパク質アルギニンメチルトランスフェラーゼ５の選択的阻害剤 Pending JP2022526604A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962829923P 2019-04-05 2019-04-05
US62/829,923 2019-04-05
PCT/US2020/026639 WO2020206299A1 (en) 2019-04-05 2020-04-03 Selective inhibitors of protein arginine methyltransferase 5

Publications (2)

Publication Number Publication Date
JP2022526604A JP2022526604A (ja) 2022-05-25
JP2022526604A5 true JP2022526604A5 (enExample) 2023-04-07

Family

ID=72667388

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021559255A Pending JP2022526604A (ja) 2019-04-05 2020-04-03 タンパク質アルギニンメチルトランスフェラーゼ５の選択的阻害剤

Country Status (4)

Country Link
US (1) US12440506B2 (enExample)
EP (1) EP3946352B1 (enExample)
JP (1) JP2022526604A (enExample)
WO (1) WO2020206299A1 (enExample)

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US11077101B1 (en) 2018-07-18 2021-08-03 Tango Therapeutics, Inc. Compounds and methods of use
US12403137B2 (en) 2019-10-28 2025-09-02 Tango Therapeutics, Inc. Compounds and methods of use
WO2022026892A1 (en) 2020-07-31 2022-02-03 Tango Therapeutics, Inc. Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers
CN113234079B (zh) * 2021-04-30 2022-02-01 上海湃隆生物科技有限公司 用作prmt5抑制剂的核苷类似物
CN113546173B (zh) * 2021-08-19 2022-08-23 徐州医科大学 Prmt5抑制剂在制备治疗冠状病毒感染所引起的疾病的药物中的应用
WO2024170488A1 (en) 2023-02-13 2024-08-22 Astrazeneca Ab Prmt5 inhibitor for use in cancer therapy
WO2024238628A1 (en) * 2023-05-15 2024-11-21 Prelude Therapeutics Incorporated Treatment of recurrent high-grade glioma or uveal melanoma (um) using a brain-penetrant protein arginine methyltransferase 5 (prmt5) inhibitor

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ES2334924T3 (es) 2005-03-17 2010-03-17 Proyecto De Biomedicina Cima, S.L. Empleo de 5'-metiltioadenosina (mta) en la prevencion y/o tratamiento de enfermedades autoinmunes y/o rechazo de trasplantes.
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TWI870767B (zh) * 2015-08-26 2025-01-21 比利時商健生藥品公司 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物
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WO2018081451A1 (en) * 2016-10-26 2018-05-03 Indiana University Research And Technology Corporation Small molecule protein arginine methyltransferase 5 (prmt5) inhibitors and methods of treatment
WO2018085818A1 (en) 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
WO2018085833A2 (en) 2016-11-07 2018-05-11 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyl transferase 5 (prmt5)
WO2018152501A1 (en) 2017-02-20 2018-08-23 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
US11220524B2 (en) 2017-02-20 2022-01-11 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
WO2018160824A1 (en) 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
WO2018160855A1 (en) 2017-03-01 2018-09-07 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
EP3939986A1 (en) * 2017-08-09 2022-01-19 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
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AU2019235912B2 (en) * 2018-03-14 2024-03-21 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
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