WO2018075601A1 - Selective inhibitors of protein arginine methyltransferase 5 (prmt5) - Google Patents

Selective inhibitors of protein arginine methyltransferase 5 (prmt5) Download PDF

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Publication number
WO2018075601A1
WO2018075601A1 PCT/US2017/057117 US2017057117W WO2018075601A1 WO 2018075601 A1 WO2018075601 A1 WO 2018075601A1 US 2017057117 W US2017057117 W US 2017057117W WO 2018075601 A1 WO2018075601 A1 WO 2018075601A1
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WO
WIPO (PCT)
Prior art keywords
alk
alkyl
cycloalkyl
nh
compound
Prior art date
Application number
PCT/US2017/057117
Other languages
French (fr)
Inventor
Juan Luengo
Krishna Vaddi
Hong Lin
Original Assignee
Prelude Therapeutics, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201662409688P priority Critical
Priority to US62/409,688 priority
Application filed by Prelude Therapeutics, Incorporated filed Critical Prelude Therapeutics, Incorporated
Publication of WO2018075601A1 publication Critical patent/WO2018075601A1/en

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