JP2022523467A - 動的な薬物動態を修飾するアンカー - Google Patents

動的な薬物動態を修飾するアンカー Download PDF

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JP2022523467A
JP2022523467A JP2021541230A JP2021541230A JP2022523467A JP 2022523467 A JP2022523467 A JP 2022523467A JP 2021541230 A JP2021541230 A JP 2021541230A JP 2021541230 A JP2021541230 A JP 2021541230A JP 2022523467 A JP2022523467 A JP 2022523467A
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oligonucleotide
chain
nucleotides
anchor
compound according
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JP2022523467A5 (https=
JPWO2020150636A5 (https=
Inventor
コボロバ，アナスタシア
ミゲル ダ クルス ゴディーニョ，ブルーノ
ハスラー，マシュー
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University of Massachusetts Amherst
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University of Massachusetts Amherst
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Publication of JPWO2020150636A5 publication Critical patent/JPWO2020150636A5/ja
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2021541230A 2019-01-18 2020-01-17 動的な薬物動態を修飾するアンカー Pending JP2022523467A (ja)

Priority Applications (1)

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JP2025171576A JP2026010059A (ja) 2019-01-18 2025-10-10 動的な薬物動態を修飾するアンカー

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US201962794123P 2019-01-18 2019-01-18
US62/794,123 2019-01-18
PCT/US2020/014146 WO2020150636A1 (en) 2019-01-18 2020-01-17 Dynamic pharmacokinetic-modifying anchors

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JP2025171576A Division JP2026010059A (ja) 2019-01-18 2025-10-10 動的な薬物動態を修飾するアンカー

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JP2022523467A true JP2022523467A (ja) 2022-04-25
JP2022523467A5 JP2022523467A5 (https=) 2023-01-26
JPWO2020150636A5 JPWO2020150636A5 (https=) 2023-01-26

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JP2025171576A Pending JP2026010059A (ja) 2019-01-18 2025-10-10 動的な薬物動態を修飾するアンカー

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US (2) US11492619B2 (https=)
EP (1) EP3911747A4 (https=)
JP (2) JP2022523467A (https=)
CN (1) CN113614232A (https=)
AU (1) AU2020207935A1 (https=)
CA (1) CA3125441A1 (https=)
WO (1) WO2020150636A1 (https=)

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WO2017132669A1 (en) 2016-01-31 2017-08-03 University Of Massachusetts Branched oligonucleotides
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
WO2020033899A1 (en) 2018-08-10 2020-02-13 University Of Massachusetts Modified oligonucleotides targeting snps
JP7627042B2 (ja) 2018-08-23 2025-02-05 ユニバーシティー オブ マサチューセッツ Ｏ－メチルリッチ完全安定化オリゴヌクレオチド
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
MX2022001710A (es) 2019-08-09 2022-05-10 Univ Massachusetts Oligonucleótidos modificados químicamente dirigidos a los snp.
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
EP4090744A4 (en) * 2020-01-17 2024-04-10 Anastasia Khvorova UNIVERSAL DYNAMIC PHARMACOKINETIC MODIFYING ANCHORS
WO2021242883A1 (en) 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
AU2022262794A1 (en) 2021-04-23 2023-11-02 Beth Israel Deaconess Medical Center, Inc. Glycan modified nucleic acids, methods of preparation, and therapeutic uses
US20240287512A1 (en) * 2021-05-11 2024-08-29 Dicerna Pharmaceuticals, Inc. Lipid conjugation for targeting neurons of the central nervous system
AU2022299169A1 (en) 2021-06-23 2024-02-08 Beth Israel Deaconess Medical Center, Inc. Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
US20250297258A1 (en) * 2021-07-07 2025-09-25 Ractigen Therapeutics Oligonucleotide-based delivery vehicle for oligonucleotides agents and methods of use thereof
US20250000892A1 (en) * 2021-10-14 2025-01-02 Arizona Board Of Regents On Behalf Of Arizona State University Programmable delivery platforms for rna structures
CN118434863A (zh) * 2022-04-14 2024-08-02 苏州瑞博生物技术股份有限公司 缀合物与组合物及制备方法和用途
AU2023365657A1 (en) * 2022-10-17 2025-05-15 University Of Massachusetts Conjugates of sirna and antisense oligonucleotides (sirnaso) and methods of use in gene silencing
EP4689116A1 (en) * 2023-03-30 2026-02-11 Ractigen Therapeutics Vehicles for delivering oligonucleotides and methods of use thereof

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