CA3125441A1 - Dynamic pharmacokinetic-modifying anchors - Google Patents

Dynamic pharmacokinetic-modifying anchors Download PDF

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Publication number
CA3125441A1
CA3125441A1 CA3125441A CA3125441A CA3125441A1 CA 3125441 A1 CA3125441 A1 CA 3125441A1 CA 3125441 A CA3125441 A CA 3125441A CA 3125441 A CA3125441 A CA 3125441A CA 3125441 A1 CA3125441 A1 CA 3125441A1
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Canada
Prior art keywords
oligonucleotide
nucleotides
anchor
compound
strand
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Pending
Application number
CA3125441A
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English (en)
French (fr)
Inventor
Anastasia Khvorova
Bruno Miguel Da Cruz Godinho
Matthew Hassler
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University of Massachusetts Amherst
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University of Massachusetts Amherst
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Publication of CA3125441A1 publication Critical patent/CA3125441A1/en
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/3513—Protein; Peptide
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    • C12N2310/30—Chemical structure
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/30—Chemical structure
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CA3125441A 2019-01-18 2020-01-17 Dynamic pharmacokinetic-modifying anchors Pending CA3125441A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962794123P 2019-01-18 2019-01-18
US62/794,123 2019-01-18
PCT/US2020/014146 WO2020150636A1 (en) 2019-01-18 2020-01-17 Dynamic pharmacokinetic-modifying anchors

Publications (1)

Publication Number Publication Date
CA3125441A1 true CA3125441A1 (en) 2020-07-23

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ID=71614192

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Application Number Title Priority Date Filing Date
CA3125441A Pending CA3125441A1 (en) 2019-01-18 2020-01-17 Dynamic pharmacokinetic-modifying anchors

Country Status (7)

Country Link
US (2) US11492619B2 (https=)
EP (1) EP3911747A4 (https=)
JP (2) JP2022523467A (https=)
CN (1) CN113614232A (https=)
AU (1) AU2020207935A1 (https=)
CA (1) CA3125441A1 (https=)
WO (1) WO2020150636A1 (https=)

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