JP2022521825A5 - - Google Patents
Info
- Publication number
- JP2022521825A5 JP2022521825A5 JP2021557652A JP2021557652A JP2022521825A5 JP 2022521825 A5 JP2022521825 A5 JP 2022521825A5 JP 2021557652 A JP2021557652 A JP 2021557652A JP 2021557652 A JP2021557652 A JP 2021557652A JP 2022521825 A5 JP2022521825 A5 JP 2022521825A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- independently
- formula
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962825387P | 2019-03-28 | 2019-03-28 | |
| US62/825,387 | 2019-03-28 | ||
| PCT/US2020/025542 WO2020198711A1 (en) | 2019-03-28 | 2020-03-27 | Androgen receptor modulators and methods for use as proteolysis targeting chimera ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022521825A JP2022521825A (ja) | 2022-04-12 |
| JP2022521825A5 true JP2022521825A5 (enExample) | 2023-04-04 |
Family
ID=72611232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021557652A Pending JP2022521825A (ja) | 2019-03-28 | 2020-03-27 | アンドロゲン受容体モジュレーター及びタンパク質分解誘導キメラリガンドとして使用するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230078913A1 (enExample) |
| EP (1) | EP3946292A4 (enExample) |
| JP (1) | JP2022521825A (enExample) |
| KR (1) | KR20220004978A (enExample) |
| CN (1) | CN114269331A (enExample) |
| AU (1) | AU2020247255A1 (enExample) |
| CA (1) | CA3134546A1 (enExample) |
| IL (1) | IL286723A (enExample) |
| MX (1) | MX2021011827A (enExample) |
| WO (1) | WO2020198711A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016141458A1 (en) | 2015-03-12 | 2016-09-15 | British Columbia Cancer Agency Branch | Bisphenol ether derivatives and methods for using the same |
| US20170298033A1 (en) | 2016-04-15 | 2017-10-19 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
| US11485713B2 (en) | 2018-05-25 | 2022-11-01 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| WO2020198712A1 (en) | 2019-03-28 | 2020-10-01 | Essa Pharma, Inc. | Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof |
| AU2020405129A1 (en) | 2019-12-19 | 2022-06-23 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CN115916170A (zh) | 2020-04-17 | 2023-04-04 | 埃萨制药股份有限公司 | 固体形式的n-末端结构域雄激素受体抑制剂及其用途 |
| CR20220630A (es) | 2020-05-09 | 2023-01-23 | Arvinas Operations Inc | Métodos para fabricar un compuesto bifuncional, formas ultrapuras del compuesto bifuncional y formas de dosificación que comprenden el mismo |
| CN116529248B (zh) * | 2020-11-25 | 2025-10-17 | 西藏海思科制药有限公司 | 一种苯环衍生物及其组合物和药学上的应用 |
| TWI813106B (zh) | 2020-12-30 | 2023-08-21 | 財團法人工業技術研究院 | 雄性激素受體結合分子及其用途 |
| KR20240020735A (ko) | 2021-05-07 | 2024-02-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | Cdk2 분해제 및 그 용도 |
| KR20240053589A (ko) * | 2021-07-30 | 2024-04-24 | 하이노바 파마슈티컬스 인코포레이티드 | 이중 기능성 키메라 헤테로 고리 화합물 및 이의 안드로겐 수용체 분해제로서의 용도 |
| WO2023046283A1 (en) * | 2021-09-22 | 2023-03-30 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity |
| EP4438603A4 (en) | 2021-11-25 | 2025-06-11 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | CHIMERIC COMPOUND FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF |
| KR20240128831A (ko) | 2021-12-30 | 2024-08-27 | 베이진 스위찰랜드 게엠베하 | 브루톤 티로신 키나아제(btk) 억제제와 e3 리가아제 리간드의 접합에 의한 btk의 분해 및 사용 방법 |
| US20250205344A1 (en) | 2022-03-24 | 2025-06-26 | Glaxosmithkline Intellectual Property Development Limited | 2,4-dioxotetrahydropyrimidinyl deratives as degrons in protacs |
| WO2024006207A1 (en) * | 2022-06-26 | 2024-01-04 | Essa Pharma Inc. | An n-terminal domain androgen receptor inhibitor and uses thereof |
| TW202535392A (zh) | 2023-12-08 | 2025-09-16 | 美商亞文納營運公司 | 使用雄性素受體降解劑治療脊髓延髓性肌肉萎縮 |
| CN119684303A (zh) * | 2023-12-28 | 2025-03-25 | 上海超阳药业有限公司 | 一种双功能可降解雄激素受体的杂环化合物及其应用 |
| WO2025152998A1 (en) * | 2024-01-17 | 2025-07-24 | Foshan Ionova Biotherapeutics Co., Inc. | Compounds for the targeted degradation of androgen receptor and use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516835A (zh) * | 2006-07-19 | 2009-08-26 | 俄亥俄州立大学研究基金会 | 选择性雄激素受体调节剂、它们的类似物和衍生物以及它们的用途 |
| MA37975B2 (fr) * | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| DK3988541T3 (da) * | 2015-01-13 | 2024-09-16 | British Columbia Cancer Agency Branch | Heterocycliske forbindelser til billedscanning og behandling af cancer samt fremgangsmåder til anvendelse af disse |
| WO2016141458A1 (en) * | 2015-03-12 | 2016-09-15 | British Columbia Cancer Agency Branch | Bisphenol ether derivatives and methods for using the same |
| EP3445765A4 (en) * | 2016-04-22 | 2019-09-18 | Dana Farber Cancer Institute, Inc. | DECREASE OF CYCLINE-DEPENDENT KINASE 4/6 (CDK4 / 6) BY CONJUGATION OF CDK4 / 6 INHIBITORS WITH E3-LIGASE LIGANDS AND METHODS OF USE |
| WO2018106870A1 (en) * | 2016-12-08 | 2018-06-14 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating cdk4/6-mediated cancer |
| JP2020505327A (ja) * | 2016-12-23 | 2020-02-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | Ｅｇｆｒタンパク質分解標的化キメラ分子およびその関連する使用方法 |
-
2020
- 2020-03-27 CN CN202080036492.3A patent/CN114269331A/zh active Pending
- 2020-03-27 AU AU2020247255A patent/AU2020247255A1/en not_active Abandoned
- 2020-03-27 WO PCT/US2020/025542 patent/WO2020198711A1/en not_active Ceased
- 2020-03-27 US US17/599,341 patent/US20230078913A1/en not_active Abandoned
- 2020-03-27 KR KR1020217034497A patent/KR20220004978A/ko not_active Ceased
- 2020-03-27 EP EP20778151.9A patent/EP3946292A4/en not_active Withdrawn
- 2020-03-27 MX MX2021011827A patent/MX2021011827A/es unknown
- 2020-03-27 CA CA3134546A patent/CA3134546A1/en active Pending
- 2020-03-27 JP JP2021557652A patent/JP2022521825A/ja active Pending
-
2021
- 2021-09-26 IL IL286723A patent/IL286723A/en unknown
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