CA3134546A1 - Androgen receptor modulators and methods for use as proteolysis targeting chimera ligands - Google Patents

Androgen receptor modulators and methods for use as proteolysis targeting chimera ligands Download PDF

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Publication number
CA3134546A1
CA3134546A1 CA3134546A CA3134546A CA3134546A1 CA 3134546 A1 CA3134546 A1 CA 3134546A1 CA 3134546 A CA3134546 A CA 3134546A CA 3134546 A CA3134546 A CA 3134546A CA 3134546 A1 CA3134546 A1 CA 3134546A1
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alkyl
optionally substituted
independently
compound
bond
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French (fr)
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Raymond John Andersen
Han-Jie Zhou
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University of British Columbia
ESSA Pharma Inc
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University of British Columbia
ESSA Pharma Inc
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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KR20240053589A (ko) * 2021-07-30 2024-04-24 하이노바 파마슈티컬스 인코포레이티드 이중 기능성 키메라 헤테로 고리 화합물 및 이의 안드로겐 수용체 분해제로서의 용도
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