JP2022519651A - 織布細胞培養基材 - Google Patents

織布細胞培養基材 Download PDF

Info

Publication number
JP2022519651A
JP2022519651A JP2021545834A JP2021545834A JP2022519651A JP 2022519651 A JP2022519651 A JP 2022519651A JP 2021545834 A JP2021545834 A JP 2021545834A JP 2021545834 A JP2021545834 A JP 2021545834A JP 2022519651 A JP2022519651 A JP 2022519651A
Authority
JP
Japan
Prior art keywords
cell culture
substrate
cells
cell
mesh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021545834A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022519651A5 (https=
Inventor
ミージン フェリー，アン
ニコラエヴィチ ゴラール，ヴァシリー
イー ロメオ，ロリ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corning Inc
Original Assignee
Corning Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corning Inc filed Critical Corning Inc
Publication of JP2022519651A publication Critical patent/JP2022519651A/ja
Publication of JP2022519651A5 publication Critical patent/JP2022519651A5/ja
Priority to JP2024026574A priority Critical patent/JP7789460B2/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C12N2533/40—Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2021545834A 2019-02-05 2020-02-04 織布細胞培養基材 Pending JP2022519651A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024026574A JP7789460B2 (ja) 2019-02-05 2024-02-26 織布細胞培養基材

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962801325P 2019-02-05 2019-02-05
US62/801,325 2019-02-05
US201962910696P 2019-10-04 2019-10-04
US62/910,696 2019-10-04
PCT/US2020/016576 WO2020163329A1 (en) 2019-02-05 2020-02-04 Woven cell culture substrates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024026574A Division JP7789460B2 (ja) 2019-02-05 2024-02-26 織布細胞培養基材

Publications (2)

Publication Number Publication Date
JP2022519651A true JP2022519651A (ja) 2022-03-24
JP2022519651A5 JP2022519651A5 (https=) 2023-02-14

Family

ID=69740833

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021545834A Pending JP2022519651A (ja) 2019-02-05 2020-02-04 織布細胞培養基材
JP2024026574A Active JP7789460B2 (ja) 2019-02-05 2024-02-26 織布細胞培養基材

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024026574A Active JP7789460B2 (ja) 2019-02-05 2024-02-26 織布細胞培養基材

Country Status (7)

Country Link
US (14) US11692161B2 (https=)
EP (1) EP3921405A1 (https=)
JP (2) JP2022519651A (https=)
KR (1) KR102712685B1 (https=)
CN (2) CN120607963A (https=)
SG (1) SG11202108505XA (https=)
WO (1) WO2020163329A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240014355A (ko) * 2022-07-25 2024-02-01 김무중 균사체 활착 유도 배양장치 및 배양방법
WO2025154803A1 (ja) * 2024-01-18 2025-07-24 日産化学株式会社 細胞を均一に播種する方法

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6987080B2 (ja) 2016-05-05 2021-12-22 サウスウェスト リサーチ インスティテュート 細胞増殖のための三次元バイオリアクター及び関連用途
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
JP7376576B2 (ja) 2018-09-24 2023-11-08 サウスウェスト リサーチ インスティテュート 三次元バイオリアクター
WO2020163329A1 (en) 2019-02-05 2020-08-13 Corning Incorporated Woven cell culture substrates
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same
AU2020386085B2 (en) 2019-11-20 2022-08-11 Upside Foods, Inc. Apparatuses and systems for preparing a meat product
CN114761534B (zh) 2019-11-27 2025-09-16 康宁股份有限公司 固定床细胞培养和收获系统及其使用方法
US12595452B2 (en) 2020-05-29 2026-04-07 Univercells Technologies Sa System and method for the production of biomolecules
WO2022061121A1 (en) * 2020-09-17 2022-03-24 Carnegie Mellon University Shape-complementing, porosity-matching perfusion bioreactor system for engineering geometrically complex tissue grafts
WO2022076639A2 (en) * 2020-10-09 2022-04-14 Corning Incorporated Surface-modified cell culture substrates and methods of modifying cell culture substrates
EP4251726A1 (en) * 2020-11-30 2023-10-04 Corning Incorporated Packed bed bioreactors with controlled zonal porosity
US20220195368A1 (en) * 2020-12-21 2022-06-23 Upside Foods, Inc. Fluid conduit with radial expansion of fluid flow
US11912967B2 (en) 2020-12-22 2024-02-27 Upside Foods, Inc. Systems and methods for cultivating tissue on porous substrates
US20240166982A1 (en) * 2021-03-19 2024-05-23 The Trustees Of The Stevens Institute Of Technology Functionally graded biomaterial structures for programmable tissue and organ biofabrication
US20240368516A1 (en) * 2021-04-06 2024-11-07 Corning Incorporated Cell culture sampling substrate for fixed bed reactor
EP4334427A1 (en) * 2021-05-03 2024-03-13 Corning Incorporated Fixed bed bioreactor for cell culture and harvesting and related methods
EP4347783A1 (en) * 2021-06-03 2024-04-10 Univercells Technologies SA Bioreactor system with enhanced cell harvesting capabilities and related methods
US11752509B2 (en) * 2021-06-17 2023-09-12 Upside Foods, Inc. Fluid dispenser for recovering material from a surface
WO2023009374A1 (en) * 2021-07-30 2023-02-02 Corning Incorporated Uniform cell culture substrate for fixed bed bioreactor
EP4377436A1 (en) * 2021-07-30 2024-06-05 Corning Incorporated Uniform cell culture substrate for fixed bed bioreactor
WO2023043615A1 (en) * 2021-09-15 2023-03-23 Corning Incorporated Fiberglass cell culture substrates for fixed bed bioreactors
US11319520B1 (en) * 2021-09-21 2022-05-03 Upside Foods, Inc. Filter cake-based systems and methods for the cultivation of cells and cell biomass
AU2022377625B2 (en) 2021-10-28 2025-01-02 Southwest Research Institute Devices for cell separation
US11959054B2 (en) 2021-11-04 2024-04-16 Upside Foods, Inc. Substrate apparatus with multi-layer substrate for cell-based meat cultivators
CA3249700A1 (en) 2022-01-26 2023-08-03 Univercells Technologies Sa BIOMASS PREDICTION/ESTIMATION SYSTEM BASED ON PARAMETER DETECTION FOR FIXED-BED BIOREACTORS AND ASSOCIATED PROCESSES
EP4544018A1 (en) * 2022-06-22 2025-04-30 Corning Incorporated Fixed bed cell culture reactor vessel for substrate alignment and sampling
US11981884B2 (en) 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same
WO2024102296A1 (en) 2022-11-08 2024-05-16 Corning Incorporated Adherent cell culture systems with removable witness substrates for cell sampling
WO2024107345A1 (en) 2022-11-15 2024-05-23 Corning Incorporated Systems and methods of differentiating stem cells within bioreactor
EP4619497A1 (en) * 2022-11-15 2025-09-24 Corning Incorporated Systems and methods for coating a bioreactor substrate
EP4619499A2 (en) 2022-11-18 2025-09-24 Univercells Technologies SA Systems and methods for recovering target biomolecules from fixed bed bioreactors
WO2024118423A1 (en) 2022-11-30 2024-06-06 Corning Incorporated Systems and methods for organizing cell substrates in bioreactors
CN121219392A (zh) 2023-05-31 2025-12-26 康宁股份有限公司 用于提高固定床生物反应器的细胞收集效率的方法
EP4497814A1 (de) 2023-07-28 2025-01-29 Green Elephant Biotech GmbH Vorrichtung zur vermehrung von differenzierten und undifferenzierten zellen und verwendung der vorrichtung für die herstellung von kultivierten lebensmitteln
WO2025117320A1 (en) 2023-11-30 2025-06-05 Corning Incorporated Cell culture bioreactor system with bidirectional perfusion and related methods
WO2025198984A1 (en) 2024-03-18 2025-09-25 Corning Incorporated Methods for attaching mesh inserts to the interior region of a roller bottle for improved performance

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62171672A (ja) * 1985-10-24 1987-07-28 Oosakashi バイオリアクタ−
WO1998050522A1 (en) * 1997-05-07 1998-11-12 Baxter International Inc. Method and apparatus for high volume production of viral particles
WO2001003750A1 (en) * 1999-07-09 2001-01-18 Advanced Tissue Sciences, Inc. Human naturally secreted extracellular matrix-coated device
US20040152149A1 (en) * 2002-10-31 2004-08-05 Reid Lola M. Textiles for use in bioreactors for expansion and maintenance of cells
JP2008054521A (ja) * 2006-08-29 2008-03-13 Canon Inc 細胞培養処理装置及び細胞培養処理方法
WO2015005349A1 (ja) * 2013-07-09 2015-01-15 国立大学法人東京大学 細胞培養支持体、細胞培養装置、細胞培養キット、及び細胞シート
JP2016136868A (ja) * 2015-01-26 2016-08-04 株式会社積進 細胞培養装置
WO2018021367A1 (ja) * 2016-07-25 2018-02-01 宇部興産株式会社 細胞の培養方法、懸濁された細胞の除去方法及び懸濁された細胞を死滅させる方法
WO2018051415A1 (ja) * 2016-09-13 2018-03-22 次郎 大野 ３次元細胞構造体の製造方法およびそれに用いる支持体

Family Cites Families (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1143460A (en) 1914-10-09 1915-06-15 Roy H Stull Engine-starter.
GB1376131A (en) 1971-02-09 1974-12-04 Nat Res Dev Improvements in and relating to cell culture systems
US4201845A (en) 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
US4292972A (en) 1980-07-09 1981-10-06 E. R. Squibb & Sons, Inc. Lyophilized hydrocolloio foam
US4755281A (en) 1984-05-01 1988-07-05 Mobil Oil Corporation Countercurrent process with froth control for treating heavy hydrocarbons
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
DE3536349A1 (de) 1985-10-11 1987-04-16 Kraftwerk Union Ag Festbettreaktor fuer biochemische prozesse
US4734373A (en) 1986-06-24 1988-03-29 Bartal Arie H Apparatus for enhancing cell growth, preservation and transport
JPH0611290B2 (ja) 1986-11-05 1994-02-16 住友ベークライト株式会社 ポリビニルアルコ−ルゲルのγ線滅菌法
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US4833083A (en) 1987-05-26 1989-05-23 Sepragen Corporation Packed bed bioreactor
GB8716997D0 (en) 1987-07-18 1987-08-26 Sterilin Ltd Cell culture vessel
US4994388A (en) 1988-04-15 1991-02-19 Solohill Engineering, Inc. Collagen-coated polystyrene microcarrier beads
US5079168A (en) 1988-08-10 1992-01-07 Endotronics, Inc. Cell culture apparatus
US5057221A (en) 1988-12-19 1991-10-15 Weyerhaeuser Company Aerobic biological dehalogenation reactor
US5262320A (en) * 1990-06-18 1993-11-16 Massachusetts Institute Of Technology Cell-culturing apparatus and method employing a macroporous support
AU9031591A (en) 1990-10-29 1992-05-26 Regents Of The University Of Minnesota A bioartificial liver
JPH05179381A (ja) 1991-12-26 1993-07-20 Furukawa Alum Co Ltd 真空ろう付け用アルミニウム合金ブレージングシート
US5840777A (en) 1992-06-19 1998-11-24 Albany International Corp. Method of producing polysaccharide foams
WO1994017178A1 (en) 1993-01-29 1994-08-04 New Brunswick Scientific Co., Inc. Method and apparatus for anchorage and suspension cell culture
US6284284B1 (en) 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US5843766A (en) 1995-06-07 1998-12-01 Advanced Tissue Sciences, Inc. Apparatus for the growth and packaging of three dimensional tissue cultures
WO1997008291A1 (en) 1995-08-31 1997-03-06 Ashby Scientific Ltd. Apparatus and methods for culturing biological material
IL118376A0 (en) 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
US6054142A (en) 1996-08-01 2000-04-25 Cyto Therapeutics, Inc. Biocompatible devices with foam scaffolds
US5998184A (en) * 1997-10-08 1999-12-07 Unisyn Technologies, Inc. Basket-type bioreactor
GB9803362D0 (en) 1998-02-17 1998-04-15 Cellon Sa A cell culture vessel
US6313103B1 (en) 1998-05-13 2001-11-06 Carrington Laboratories, Inc. Pectic substance as a growth factor stabilizer
JP4222658B2 (ja) 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
JP4601746B2 (ja) 1999-10-25 2010-12-22 エイブル株式会社 三次元動物細胞培養装置及び培養方法
AU2001294922A1 (en) 2000-10-02 2002-04-15 Thomas F. Cannon Automated bioculture and bioculture experiments system
WO2002060971A1 (fr) 2001-01-31 2002-08-08 Seikagaku Corporation Eponge polysaccharidique reticulee
US6995013B2 (en) 2002-07-08 2006-02-07 Biomed Solutions, Llc Cell-scaffold composition containing five layers
JP2002306155A (ja) 2001-03-27 2002-10-22 Becton Dickinson & Co 細胞を培養するための方法および装置
US7524513B2 (en) 2001-06-15 2009-04-28 Mao Hai-Quan Biofunctional fibers
US6875605B1 (en) 2002-08-21 2005-04-05 Florida State University Research Foundation, Inc. Modular cell culture bioreactor and associated methods
US7449331B2 (en) 2002-09-20 2008-11-11 Whitley Kenneth W Roller bottle
US6955892B2 (en) * 2002-11-12 2005-10-18 Akzo Nobel N.V. Feeding processes for fermentation
US20040211747A1 (en) 2003-01-02 2004-10-28 Whitley Kenneth W. Roller bottle
US20050014774A1 (en) 2003-04-28 2005-01-20 Richard Storer Oxo-pyrimidine compounds
JPWO2005014774A1 (ja) 2003-08-11 2006-10-26 独立行政法人農業生物資源研究所 動物細胞の培養担体と、該培養担体を用いた動物細胞の培養方法および移植方法
US7674837B2 (en) 2003-09-08 2010-03-09 Fmc Biopolymer As Gelled biopolymer based foam
CN101120083B (zh) 2003-10-08 2013-03-27 威尔森沃尔夫制造公司 利用透气性材料进行细胞培养的方法及装置
US7771992B2 (en) 2003-11-24 2010-08-10 Leica Biosystems Richmond, Inc. Apparatus and method for preparing tissue samples for histological examination
EP1784481A1 (en) 2004-08-25 2007-05-16 Technion Research And Development Foundation, Ltd. Methods of generating embryoid bodies using three dimensional scaffolds
US20100203638A1 (en) 2005-02-15 2010-08-12 School Juridical Person Kitasato Gakuen Method of Producing High-Density Cultured Tissue and High-Density Cultured Tissue
AU2006287306A1 (en) 2005-09-09 2007-03-15 Duke University Tissue engineering methods and compositions
BE1016793A4 (fr) 2005-10-04 2007-06-05 Artelis Procede de culture de cellules et dispositif permettant sa mise en oeuvre.
US8951784B2 (en) 2005-12-14 2015-02-10 Sepragen Corporation Cell culture bioreactor
US20090041825A1 (en) 2006-02-10 2009-02-12 Kotov Nicholas A Cell culture well-plates having inverted colloidal crystal scaffolds
WO2007098040A1 (en) 2006-02-17 2007-08-30 Novartis Ag Method for sterilization of hydrogel contact lenses
WO2007102606A1 (ja) 2006-03-06 2007-09-13 Teijin Limited 足場材料
US20070218038A1 (en) 2006-03-17 2007-09-20 Pegasus Biologics, Inc. Stabilized, sterilized collagen scaffolds with active adjuncts attached
US7618485B2 (en) 2006-06-16 2009-11-17 The Biodegradable Technologies General Partnership Biodegradable compositions, articles prepared from biodegradable compositions and manufacturing methods
WO2008016673A2 (en) 2006-08-01 2008-02-07 Thefeinstein Institute For Medical Research Bioactive scaffolds
CN200940147Y (zh) 2006-08-30 2007-08-29 仪忠军 细胞贴壁培养用三层玻璃转瓶
US7291196B1 (en) 2006-11-16 2007-11-06 Lerner Bernard J Filamentary pad for improved mist elimination and mass transfer
EP1938690B1 (de) 2006-12-22 2013-10-23 Preentec AG Sterilisierung und Konservierung von Fluiden
EP2134830A2 (en) 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
CN101245313A (zh) 2007-02-13 2008-08-20 刘青 三维细胞培养插入件、其制造方法、成套用具及用途
AU2008220791A1 (en) 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system with surface increasing substrate
US20080305539A1 (en) 2007-06-08 2008-12-11 Robert Hickey Membrane supported bioreactor for conversion of syngas components to liquid products
US8198087B2 (en) 2007-07-30 2012-06-12 Sofradim Production Sas Tissue engineering support
US8524494B2 (en) 2008-01-30 2013-09-03 Histogen, Inc. Low oxygen tension and BFGF generates a multipotent stem cell from a fibroblast in vitro
JP2011518837A (ja) 2008-04-24 2011-06-30 メドトロニック，インコーポレイテッド 再水和可能なチオール化多糖粒子およびスポンジ
WO2009132229A2 (en) 2008-04-24 2009-10-29 Medtronic, Inc. Cold ionizing radiation sterilization
AT506826B1 (de) 2008-05-23 2010-03-15 Greiner Bio One Gmbh Bioreaktor und verfahren zum kultivieren von zellen und geweben
WO2010039933A2 (en) 2008-10-02 2010-04-08 The Regents Of The University Of California Methods and compositions for high-resolution micropatterning for cell culture
US9249383B2 (en) 2008-10-08 2016-02-02 Agency For Science Technology & Research Apparatus for culturing anchorage dependent cells
EP2346984A4 (en) 2008-10-22 2013-10-30 Biovest Int Inc PERFUSION BIOREACTOR, CELL CULTURE SYSTEMS AND METHODS FOR PRODUCING CELLS AND CELL DERIVED PRODUCTS
WO2010069320A2 (en) 2008-12-19 2010-06-24 Stobbe Tech A/S Biopharmaceutical plant in a column
EP2401353B1 (en) 2009-02-25 2015-04-29 Corning Incorporated Cell culture system with manifold
EP3330368B1 (en) 2009-06-18 2021-07-21 Kiyatec Inc. Bioreactor system
US8507263B2 (en) * 2009-08-07 2013-08-13 Maria Adelaide Asnaghi Rotating bioreactor
JP5893566B2 (ja) 2009-10-29 2016-03-23 アセンディス ファーマ エー／エス 生分解性ヒドロゲルの滅菌
GB0921836D0 (en) 2009-12-14 2010-01-27 Prebble Andrew Anaerobic reactor
US8721963B2 (en) 2010-03-29 2014-05-13 University Of South Carolina Cold sterilization of tissue engineering scaffolds with compressed carbon dioxide
ES2588978T3 (es) 2010-04-02 2016-11-08 Interdigital Patent Holdings, Inc. Configuración y transmisión de señales de sondeo de referencia de enlace ascendente
US20110275056A1 (en) 2010-05-04 2011-11-10 Caridianbct, Inc. Method and Apparatus for Controlling a Cell Expansion Apparatus
US20160145567A1 (en) 2010-05-27 2016-05-26 Corning Incorporated Cell culture article and methods thereof
US9290372B2 (en) 2010-06-15 2016-03-22 Ge Healthcare Bio-Sciences Ab Fluid distributor unit
WO2011161088A2 (en) * 2010-06-23 2011-12-29 Stobbe Tech. A/S Biopharmaceutical process apparatuses assembled into a column
CN102409020A (zh) * 2010-09-26 2012-04-11 上海泰因生物技术有限公司 一种无纺布/聚酯类纤维培养细胞用载体及其使用方法
US9220810B2 (en) 2010-12-10 2015-12-29 Florida State University Research Foundation, Inc. Mesenchymal stem cells (MSC) expansion methods and materials
CN103476924A (zh) 2011-04-15 2013-12-25 普拉里斯坦有限公司 收获细胞的方法和系统
SE1130042A1 (sv) 2011-05-17 2012-11-18 Belagt nanofibernätverk för tredimensionell cellodling av neurala celler
CN102250390B (zh) 2011-05-25 2012-10-31 天津大学 海藻酸盐水凝胶微载体及其制备方法
US9211107B2 (en) 2011-11-07 2015-12-15 C. R. Bard, Inc. Ruggedized ultrasound hydrogel insert
KR102015933B1 (ko) 2012-04-08 2019-08-29 인벤트프라이즈 엘엘씨 백신 제조를 위한 바이러스의 세포 배양 증폭 시스템 및 방법
CN104540933A (zh) 2012-08-20 2015-04-22 泰尔茂比司特公司 在细胞扩增系统的生物反应器中加载和分配细胞的方法
EP2931871B1 (en) * 2012-12-11 2026-03-04 Pall Technology UK limited Recipient for cell cultivation
JP5939650B2 (ja) 2013-01-07 2016-06-22 賽宇細胞科技股▲ふん▼有限公司 充填ベッド培養装置のための大規模な細胞採取方法
CN103113627B (zh) 2013-01-17 2015-03-25 黑龙江省重生生物科技有限公司 一种用于细胞培养的多糖/Matrigel复合凝胶膜及其制备方法和应用
US20140243995A1 (en) 2013-02-28 2014-08-28 The Massachusetts Institute Of Technology Stacked planar sheet tissue engineering scaffolds with 3d structural order
EP3013940B1 (en) 2013-06-24 2017-04-12 Corning Incorporated Cell culture article and methods thereof
JP2016526387A (ja) 2013-06-24 2016-09-05 アントフロゲネシス コーポレーション 細胞培養のための細胞外マトリクス組成物ビーズ
GB2520300A (en) 2013-11-15 2015-05-20 Univ Loughborough Cell Culture System
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
EP3105311A1 (en) 2014-02-10 2016-12-21 Univercells NV System, apparatus and method for biomolecules production
CN104212714B (zh) 2014-09-16 2016-02-10 上海保兴生物设备工程有限公司 多层填充床生物反应器
CN204079991U (zh) 2014-09-16 2015-01-07 上海保兴生物设备工程有限公司 一种多层填充床生物反应器
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
SG11201705866XA (en) 2015-01-26 2017-08-30 Ube Industries Method, device and kit for mass cultivation of cells using polyimide porous membrane
MA41506A (fr) 2015-02-13 2017-12-19 Takeda Vaccines Inc Procédés de production de virus pour produire des vaccins
CN106032520A (zh) 2015-03-13 2016-10-19 基因港(香港)生物科技有限公司 固定化反应装置及利用固定化技术进行反应的方法
WO2016200888A1 (en) 2015-06-08 2016-12-15 Corning Incorporated Digestible substrates for cell culture
IL324677A (en) 2015-06-23 2026-01-01 Univ Texas Methods and apparatus for growing cell populations for cell therapy
EP3344755A4 (en) * 2015-08-31 2019-05-22 I Peace, Inc. PREPARATION SYSTEM FOR PLURIPOTENTE STEM CELLS AND METHOD FOR THE PRODUCTION OF INDUCED PLURIPOTENTAL STEM CELLS
TWI672375B (zh) 2015-12-09 2019-09-21 財團法人工業技術研究院 細胞培養載體模組、生物反應器及細胞回收方法
DK3430119T3 (da) 2016-03-14 2023-09-18 Omnibrx Biotechnologies Private Ltd Et bioreaktorsystem og dets funktion
EP3452575A4 (en) 2016-05-05 2020-03-11 Terumo BCT, Inc. AUTOMATED PRODUCTION AND COLLECTION
JP6987080B2 (ja) * 2016-05-05 2021-12-22 サウスウェスト リサーチ インスティテュート 細胞増殖のための三次元バイオリアクター及び関連用途
WO2017204563A1 (ko) 2016-05-24 2017-11-30 주식회사 아모라이프사이언스 세포배양 지지체용 원사, 이를 포함하는 세포배양 지지체용 원단
BE1024230B1 (fr) 2016-11-08 2017-12-20 Univercells Sa Production contenue de cellules et/ou de produits cellulaires
BE1024733B1 (fr) * 2016-11-09 2018-06-14 Univercells Sa Matrice de croissance cellulaire
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
KR102447734B1 (ko) 2017-04-07 2022-09-28 에피본, 인크. 접종 및 배양용 시스템 및 방법
WO2019090211A1 (en) 2017-11-06 2019-05-09 Corning Incorporated Cell culture apparatuses with manifolds including column structures
WO2019104069A1 (en) 2017-11-21 2019-05-31 Corning Incorporated Dissolvable foam scaffolds for cell culture and methods of making the same
WO2019175442A1 (en) 2018-03-16 2019-09-19 Univercells S.A. Fixed bed sampler and related methods
CN112639069A (zh) 2018-04-23 2021-04-09 尤尼沃尔塞尔斯技术股份公司 提高产品回收率的带冷冻-解冻功能的生物反应器及相关方法
US20210115378A1 (en) 2018-05-09 2021-04-22 Yale University Compositions and systems for ex vivo cell modulation and methods of use thereof
CN108315258A (zh) 2018-05-10 2018-07-24 章毅 增大细胞培养面积的细胞培养滚瓶及其应用
EP3842526A4 (en) 2018-08-20 2022-05-25 I Peace, Inc. Method for cultivating or inducing cells
KR20210111752A (ko) * 2018-11-21 2021-09-13 더 시컨트 그룹, 엘엘씨 세포용 텍스타일 성장 매트릭스
WO2020163329A1 (en) * 2019-02-05 2020-08-13 Corning Incorporated Woven cell culture substrates
US11118151B2 (en) 2019-11-05 2021-09-14 Corning Incorporated Fixed bed bioreactor and methods of using the same
WO2021108072A1 (en) 2019-11-25 2021-06-03 Corning Incorporated Fixed bed bioreactor vessel and methods of using the same
US20210246575A1 (en) 2020-02-07 2021-08-12 University Of Georgia Research Foundation, Inc. Methods and devices for making nanofibers and nanofiber scaffolds
WO2022076519A1 (en) 2020-10-08 2022-04-14 Corning Incorporated Cell culture harvest and reseed methods and systems using dissolvable substrates
JP2024171672A (ja) 2023-05-30 2024-12-12 株式会社日立製作所 システム、コンピュータ、及びプログラム

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62171672A (ja) * 1985-10-24 1987-07-28 Oosakashi バイオリアクタ−
WO1998050522A1 (en) * 1997-05-07 1998-11-12 Baxter International Inc. Method and apparatus for high volume production of viral particles
WO2001003750A1 (en) * 1999-07-09 2001-01-18 Advanced Tissue Sciences, Inc. Human naturally secreted extracellular matrix-coated device
US20040152149A1 (en) * 2002-10-31 2004-08-05 Reid Lola M. Textiles for use in bioreactors for expansion and maintenance of cells
JP2008054521A (ja) * 2006-08-29 2008-03-13 Canon Inc 細胞培養処理装置及び細胞培養処理方法
WO2015005349A1 (ja) * 2013-07-09 2015-01-15 国立大学法人東京大学 細胞培養支持体、細胞培養装置、細胞培養キット、及び細胞シート
JP2016136868A (ja) * 2015-01-26 2016-08-04 株式会社積進 細胞培養装置
WO2018021367A1 (ja) * 2016-07-25 2018-02-01 宇部興産株式会社 細胞の培養方法、懸濁された細胞の除去方法及び懸濁された細胞を死滅させる方法
WO2018051415A1 (ja) * 2016-09-13 2018-03-22 次郎 大野 ３次元細胞構造体の製造方法およびそれに用いる支持体

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Microfluidic approaches for epithelial cell layer culture and characterisation", ANALYST, 2014年, JPN6023009195, pages 1 - 13, ISSN: 0005182131 *
"Polymer-Based Mesh as Supports for Multi-layered 3D Cell Culture and Assays", BIOMATERIALS. 2014年, vol. 35, no. 1, JPN6023009192, pages 1 - 21, ISSN: 0005182134 *
BIOMACROMOLECULES, 2015年, vol. 16, JPN6023009193, pages 3952 - 3958, ISSN: 0005182133 *
BLOOD SUBSTITUTES, AND BIOTECHNOLOGY, 1997年, vol. 25, no. 6, JPN6023009191, pages 551 - 562, ISSN: 0005182135 *
J. CELL BIOL., 1978年, vol. 77, JPN6023009194, pages 853 - 880, ISSN: 0005182132 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240014355A (ko) * 2022-07-25 2024-02-01 김무중 균사체 활착 유도 배양장치 및 배양방법
KR102798187B1 (ko) * 2022-07-25 2025-04-21 김무중 균사체 활착 유도 배양장치 및 배양방법
WO2025154803A1 (ja) * 2024-01-18 2025-07-24 日産化学株式会社 細胞を均一に播種する方法

Also Published As

Publication number Publication date
US12037572B2 (en) 2024-07-16
US20200248123A1 (en) 2020-08-06
US20210024868A1 (en) 2021-01-28
US20230235262A1 (en) 2023-07-27
US11434460B2 (en) 2022-09-06
US11692161B2 (en) 2023-07-04
US20220364031A1 (en) 2022-11-17
CN120607963A (zh) 2025-09-09
US20200248120A1 (en) 2020-08-06
US11111470B2 (en) 2021-09-07
EP3921405A1 (en) 2021-12-15
US20200248122A1 (en) 2020-08-06
US11639489B2 (en) 2023-05-02
US20200255783A1 (en) 2020-08-13
KR102712685B1 (ko) 2024-10-02
WO2020163329A1 (en) 2020-08-13
US20240336883A1 (en) 2024-10-10
US20200248124A1 (en) 2020-08-06
JP7789460B2 (ja) 2025-12-22
KR20210125036A (ko) 2021-10-15
US20220364032A1 (en) 2022-11-17
SG11202108505XA (en) 2021-09-29
CN113728085B (zh) 2025-07-04
US20240240128A1 (en) 2024-07-18
JP2024059828A (ja) 2024-05-01
US20210371791A1 (en) 2021-12-02
US20200248121A1 (en) 2020-08-06
US11401493B2 (en) 2022-08-02
US11920117B2 (en) 2024-03-05
US12180451B2 (en) 2024-12-31
US20230348833A1 (en) 2023-11-02
US12460168B2 (en) 2025-11-04
US11661576B2 (en) 2023-05-30
CN113728085A (zh) 2021-11-30

Similar Documents

Publication Publication Date Title
JP2022519651A (ja) 織布細胞培養基材
JP7518901B2 (ja) 固定床バイオリアクタおよび固定床バイオリアクタを使用する方法
JP2023544851A (ja) 表面修飾された細胞培養基材及び細胞培養基材を修飾する方法
CN117561324A (zh) 用于细胞培养和收获的固定床生物反应器及其相关方法
US20240344008A1 (en) Uniform cell culture substrate for fixed bed bioreactor
JP2025537024A (ja) バイオリアクタ基材をコーティングするためのシステム及び方法
JP2025535621A (ja) バイオリアクタ内で幹細胞を分化させるシステム及び方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230206

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230206

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20230206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230308

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230608

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230808

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230908

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20231025