JP2022518929A5 - - Google Patents
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- Publication number
- JP2022518929A5 JP2022518929A5 JP2021544144A JP2021544144A JP2022518929A5 JP 2022518929 A5 JP2022518929 A5 JP 2022518929A5 JP 2021544144 A JP2021544144 A JP 2021544144A JP 2021544144 A JP2021544144 A JP 2021544144A JP 2022518929 A5 JP2022518929 A5 JP 2022518929A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024158813A JP2025000693A (ja) | 2019-01-29 | 2024-09-13 | Ａｐｐの発現を低減するための化合物及び方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962798353P | 2019-01-29 | 2019-01-29 | |
| US62/798,353 | 2019-01-29 | ||
| US201962841169P | 2019-04-30 | 2019-04-30 | |
| US62/841,169 | 2019-04-30 | ||
| US201962915764P | 2019-10-16 | 2019-10-16 | |
| US62/915,764 | 2019-10-16 | ||
| PCT/US2020/015701 WO2020160163A1 (en) | 2019-01-29 | 2020-01-29 | Compounds and methods for reducing app expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024158813A Division JP2025000693A (ja) | 2019-01-29 | 2024-09-13 | Ａｐｐの発現を低減するための化合物及び方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022518929A JP2022518929A (ja) | 2022-03-17 |
| JP2022518929A5 true JP2022518929A5 (https=) | 2023-02-02 |
| JPWO2020160163A5 JPWO2020160163A5 (https=) | 2023-02-02 |
| JP7557469B2 JP7557469B2 (ja) | 2024-09-27 |
Family
ID=71840111
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544144A Active JP7557469B2 (ja) | 2019-01-29 | 2020-01-29 | Ａｐｐの発現を低減するための化合物及び方法 |
| JP2024158813A Pending JP2025000693A (ja) | 2019-01-29 | 2024-09-13 | Ａｐｐの発現を低減するための化合物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024158813A Pending JP2025000693A (ja) | 2019-01-29 | 2024-09-13 | Ａｐｐの発現を低減するための化合物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220380773A1 (https=) |
| EP (1) | EP3918073A4 (https=) |
| JP (2) | JP7557469B2 (https=) |
| TW (1) | TW202043472A (https=) |
| UY (1) | UY38562A (https=) |
| WO (1) | WO2020160163A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA202091693A1 (ru) | 2018-01-12 | 2021-04-14 | Бристол-Маерс Сквибб Компани | Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения |
| BR112020013994A2 (pt) | 2018-01-12 | 2020-12-08 | Bristol-Myers Squibb Company | Oligonucleotídeos antissenso que direcionam alfa-sinucleína e seus usos |
| EP3759127A4 (en) | 2018-03-02 | 2022-03-30 | Ionis Pharmaceuticals, Inc. | COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN |
| TW202039844A (zh) * | 2018-12-19 | 2020-11-01 | 美商阿尼拉製藥公司 | 類澱粉前驅蛋白（ＡＰＰ）ＲＮＡｉ劑組成物及其使用方法 |
| KR20210149107A (ko) * | 2019-04-03 | 2021-12-08 | 브리스톨-마이어스 스큅 컴퍼니 | Angptl2 안티센스 올리고뉴클레오티드 및 그의 용도 |
| EP4013767A4 (en) | 2019-08-15 | 2023-10-25 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds and uses thereof |
| AU2021315992A1 (en) | 2020-07-28 | 2023-02-09 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
| EP4284390A4 (en) * | 2021-01-29 | 2025-10-29 | Alnylam Pharmaceuticals Inc | ARNI COMPOSITIONS AND METHODS FOR SILENCER OF AMYLOID PRECURSOR PROTEIN (APP) |
| MX2024004437A (es) * | 2021-10-15 | 2024-07-01 | Alnylam Pharmaceuticals Inc | Composiciones de inhibidor de la angiotensina-receptor neprilisina (arni) de administracion extrahepatica y metodos de uso de las mismas. |
| WO2025045195A1 (zh) * | 2023-08-31 | 2025-03-06 | 上海拓界生物医药科技有限公司 | 靶向APP的RNAi剂及其医药用途 |
| WO2025228429A1 (zh) * | 2024-04-30 | 2025-11-06 | 北京安龙生物医药有限公司 | 靶向淀粉样前体蛋白基因的寡核苷酸及其用途 |
| WO2025261396A1 (zh) * | 2024-06-18 | 2025-12-26 | 艾码生物科技(南京)有限公司 | 靶向app的rna干扰方法、核酸及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2126451A1 (en) * | 1991-12-24 | 1993-07-08 | Brett P. Monia | Compositions and methods for modulating .beta.-amyloid |
| US20030232435A1 (en) * | 2002-06-14 | 2003-12-18 | Isis Pharmaceuticals Inc. | Antisense modulation of amyloid beta protein precursor expression |
| GB0324854D0 (en) * | 2003-10-24 | 2003-11-26 | Expresson Biosystems Ltd | App/ena antisense |
| JP2011514158A (ja) * | 2008-02-19 | 2011-05-06 | エダン・バイオテクノロジー・インコーポレイテッド | アミロイドベータタンパク質発現のアンチセンス調節 |
| US20100190807A1 (en) * | 2008-08-26 | 2010-07-29 | Senex Biotechnology, Inc. | CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein |
| US20110301052A1 (en) * | 2010-04-16 | 2011-12-08 | Mcneel Douglas G | Diagnostic evaluation of antibody responses to commonly recognized prostate cancer-associated antigens |
| AU2014274730A1 (en) * | 2013-06-07 | 2016-01-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating FOXP3 expression |
| JP2016531570A (ja) * | 2013-08-16 | 2016-10-13 | ラナ セラピューティクス インコーポレイテッド | ユークロマチン領域を標的とするオリゴヌクレオチド |
| EP4166667A3 (en) * | 2013-10-11 | 2023-08-02 | Ionis Pharmaceuticals, Inc. | Compositions for modulating c9orf72 expression |
| DK3137476T3 (da) * | 2014-04-28 | 2019-11-18 | Ionis Pharmaceuticals Inc | Linker-modificerede oligomerforbindelser |
| EP3759127A4 (en) * | 2018-03-02 | 2022-03-30 | Ionis Pharmaceuticals, Inc. | COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN |
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2020
- 2020-01-29 UY UY0001038562A patent/UY38562A/es not_active Application Discontinuation
- 2020-01-29 US US17/424,672 patent/US20220380773A1/en active Pending
- 2020-01-29 WO PCT/US2020/015701 patent/WO2020160163A1/en not_active Ceased
- 2020-01-29 JP JP2021544144A patent/JP7557469B2/ja active Active
- 2020-01-29 EP EP20749114.3A patent/EP3918073A4/en active Pending
- 2020-01-30 TW TW109102899A patent/TW202043472A/zh unknown
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2024
- 2024-09-13 JP JP2024158813A patent/JP2025000693A/ja active Pending