JP2021530204A5 - - Google Patents

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Publication number
JP2021530204A5
JP2021530204A5 JP2020571686A JP2020571686A JP2021530204A5 JP 2021530204 A5 JP2021530204 A5 JP 2021530204A5 JP 2020571686 A JP2020571686 A JP 2020571686A JP 2020571686 A JP2020571686 A JP 2020571686A JP 2021530204 A5 JP2021530204 A5 JP 2021530204A5
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Japan
Prior art keywords
pharmaceutical composition
modified oligonucleotide
disease
oligomer compound
lrrk2
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JP2020571686A
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English (en)
Japanese (ja)
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JP2021530204A (ja
JPWO2020006267A5 (https=
JP7315594B2 (ja
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Priority claimed from PCT/US2019/039558 external-priority patent/WO2020006267A1/en
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Publication of JPWO2020006267A5 publication Critical patent/JPWO2020006267A5/ja
Publication of JP2021530204A5 publication Critical patent/JP2021530204A5/ja
Priority to JP2023114861A priority Critical patent/JP7678033B2/ja
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Publication of JP7315594B2 publication Critical patent/JP7315594B2/ja
Priority to JP2025076009A priority patent/JP2025121956A/ja
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JP2020571686A 2018-06-27 2019-06-27 Lrrk2発現を低減するための化合物及び方法 Active JP7315594B2 (ja)

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Application Number Priority Date Filing Date Title
JP2023114861A JP7678033B2 (ja) 2018-06-27 2023-07-13 Lrrk2発現を低減するための化合物及び方法
JP2025076009A JP2025121956A (ja) 2018-06-27 2025-05-01 Lrrk2発現を低減するための化合物及び方法

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US201862690790P 2018-06-27 2018-06-27
US62/690,790 2018-06-27
PCT/US2019/039558 WO2020006267A1 (en) 2018-06-27 2019-06-27 Compounds and methods for reducing lrrk2 expression

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Publications (4)

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JP2021530204A JP2021530204A (ja) 2021-11-11
JPWO2020006267A5 JPWO2020006267A5 (https=) 2022-07-01
JP2021530204A5 true JP2021530204A5 (https=) 2022-07-01
JP7315594B2 JP7315594B2 (ja) 2023-07-26

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JP2020571686A Active JP7315594B2 (ja) 2018-06-27 2019-06-27 Lrrk2発現を低減するための化合物及び方法
JP2023114861A Active JP7678033B2 (ja) 2018-06-27 2023-07-13 Lrrk2発現を低減するための化合物及び方法
JP2025076009A Pending JP2025121956A (ja) 2018-06-27 2025-05-01 Lrrk2発現を低減するための化合物及び方法

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JP2023114861A Active JP7678033B2 (ja) 2018-06-27 2023-07-13 Lrrk2発現を低減するための化合物及び方法
JP2025076009A Pending JP2025121956A (ja) 2018-06-27 2025-05-01 Lrrk2発現を低減するための化合物及び方法

Country Status (25)

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US (4) US11332746B1 (https=)
EP (1) EP3814503A4 (https=)
JP (3) JP7315594B2 (https=)
KR (1) KR102768381B1 (https=)
CN (1) CN112400019B (https=)
AR (1) AR116102A1 (https=)
AU (1) AU2019294838B2 (https=)
BR (1) BR112020024564A2 (https=)
CA (1) CA3104676A1 (https=)
CL (1) CL2020003309A1 (https=)
CO (1) CO2020015256A2 (https=)
CR (1) CR20210044A (https=)
EA (1) EA202190140A1 (https=)
IL (1) IL279632B1 (https=)
JO (1) JOP20200334A1 (https=)
MX (1) MX2020013653A (https=)
MY (1) MY205775A (https=)
PE (1) PE20210518A1 (https=)
PH (1) PH12021500003A1 (https=)
SG (1) SG11202011864XA (https=)
TW (1) TWI833770B (https=)
UA (1) UA128406C2 (https=)
UY (1) UY38282A (https=)
WO (1) WO2020006267A1 (https=)
ZA (1) ZA202007444B (https=)

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CA3006599A1 (en) 2016-01-05 2017-07-13 Ionis Pharmaceuticals, Inc. Methods for reducing lrrk2 expression
EA202091693A1 (ru) 2018-01-12 2021-04-14 Бристол-Маерс Сквибб Компани Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения
BR112020013994A2 (pt) 2018-01-12 2020-12-08 Bristol-Myers Squibb Company Oligonucleotídeos antissenso que direcionam alfa-sinucleína e seus usos
EP3759127A4 (en) 2018-03-02 2022-03-30 Ionis Pharmaceuticals, Inc. COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
CN112654621B (zh) 2018-06-27 2024-05-14 百时美施贵宝公司 可作为t细胞活化剂的经取代萘啶酮化合物
TWI833770B (zh) 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法
IL294728A (en) * 2020-01-24 2022-09-01 Alnylam Pharmaceuticals Inc lrrk2 RNA material preparations and methods of using them
CA3182162A1 (en) 2020-05-06 2021-11-11 Les Laboratoires Servier New macrocyclic lrrk2 kinase inhibitors
AU2021315992A1 (en) * 2020-07-28 2023-02-09 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing app expression
TW202304935A (zh) 2021-03-18 2023-02-01 法商施維雅藥廠 新穎的巨環lrrk2激酶抑制劑
WO2022206816A1 (zh) * 2021-03-30 2022-10-06 南京大学 一种用于治疗帕金森的rna质粒递送系统
WO2022223515A2 (en) 2021-04-19 2022-10-27 Novo Nordisk A/S Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression
WO2022226018A1 (en) * 2021-04-20 2022-10-27 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Malignant mesothelioma susceptibility as a result of germline leucine-rich repeat kinase 2 (lrrk2) alterations
JP2024528503A (ja) * 2021-06-29 2024-07-30 アルナイラム ファーマシューティカルズ, インコーポレイテッド ロイシンリッチリピートキナーゼ2(LRRK2)iRNA剤組成物およびその使用方法
CN119013399A (zh) * 2022-01-26 2024-11-22 赛丹思科大学 靶向假外显子的等位基因特异性剪接转换寡核苷酸
JP7782719B2 (ja) 2022-10-28 2025-12-09 日本精工株式会社 回転支持装置、及び軸支持装置の支持機構位置調整機構
CN121712891A (zh) * 2023-06-20 2026-03-20 阿达尔克斯制药有限公司 Lrrk2调节组合物及其使用方法
AU2024353921A1 (en) * 2023-09-27 2026-04-16 Neuro3 Therapeutics (Suzhou) Ltd. Novel sirna constructs, therapeutics, and modifications
WO2025190385A1 (zh) * 2024-03-14 2025-09-18 上海拓界生物医药科技有限公司 靶向LRRK2的RNAi剂及其医药用途

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