KR102768381B1 - Lrrk2 발현 감소용 화합물 및 방법 - Google Patents

Lrrk2 발현 감소용 화합물 및 방법 Download PDF

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KR102768381B1
KR102768381B1 KR1020217001678A KR20217001678A KR102768381B1 KR 102768381 B1 KR102768381 B1 KR 102768381B1 KR 1020217001678 A KR1020217001678 A KR 1020217001678A KR 20217001678 A KR20217001678 A KR 20217001678A KR 102768381 B1 KR102768381 B1 KR 102768381B1
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certain embodiments
modified
delete delete
oligonucleotide
lrrk2
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트레이시 에이. 콜
홀리 코르다지에빅츠
후인-호아 부이
수잔 엠. 프라이어
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아이오니스 파마수티컬즈, 인코포레이티드
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    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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KR1020217001678A 2018-06-27 2019-06-27 Lrrk2 발현 감소용 화합물 및 방법 Active KR102768381B1 (ko)

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US201862690790P 2018-06-27 2018-06-27
US62/690,790 2018-06-27
PCT/US2019/039558 WO2020006267A1 (en) 2018-06-27 2019-06-27 Compounds and methods for reducing lrrk2 expression

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KR20210025055A KR20210025055A (ko) 2021-03-08
KR102768381B1 true KR102768381B1 (ko) 2025-02-13

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US (4) US11332746B1 (https=)
EP (1) EP3814503A4 (https=)
JP (3) JP7315594B2 (https=)
KR (1) KR102768381B1 (https=)
CN (1) CN112400019B (https=)
AR (1) AR116102A1 (https=)
AU (1) AU2019294838B2 (https=)
BR (1) BR112020024564A2 (https=)
CA (1) CA3104676A1 (https=)
CL (1) CL2020003309A1 (https=)
CO (1) CO2020015256A2 (https=)
CR (1) CR20210044A (https=)
EA (1) EA202190140A1 (https=)
IL (1) IL279632B1 (https=)
JO (1) JOP20200334A1 (https=)
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PE (1) PE20210518A1 (https=)
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CA3006599A1 (en) 2016-01-05 2017-07-13 Ionis Pharmaceuticals, Inc. Methods for reducing lrrk2 expression
EA202091693A1 (ru) 2018-01-12 2021-04-14 Бристол-Маерс Сквибб Компани Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения
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EP3759127A4 (en) 2018-03-02 2022-03-30 Ionis Pharmaceuticals, Inc. COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
CN112654621B (zh) 2018-06-27 2024-05-14 百时美施贵宝公司 可作为t细胞活化剂的经取代萘啶酮化合物
TWI833770B (zh) 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法
IL294728A (en) * 2020-01-24 2022-09-01 Alnylam Pharmaceuticals Inc lrrk2 RNA material preparations and methods of using them
CA3182162A1 (en) 2020-05-06 2021-11-11 Les Laboratoires Servier New macrocyclic lrrk2 kinase inhibitors
AU2021315992A1 (en) * 2020-07-28 2023-02-09 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing app expression
TW202304935A (zh) 2021-03-18 2023-02-01 法商施維雅藥廠 新穎的巨環lrrk2激酶抑制劑
WO2022206816A1 (zh) * 2021-03-30 2022-10-06 南京大学 一种用于治疗帕金森的rna质粒递送系统
WO2022223515A2 (en) 2021-04-19 2022-10-27 Novo Nordisk A/S Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression
WO2022226018A1 (en) * 2021-04-20 2022-10-27 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Malignant mesothelioma susceptibility as a result of germline leucine-rich repeat kinase 2 (lrrk2) alterations
JP2024528503A (ja) * 2021-06-29 2024-07-30 アルナイラム ファーマシューティカルズ， インコーポレイテッド ロイシンリッチリピートキナーゼ２（ＬＲＲＫ２）ｉＲＮＡ剤組成物およびその使用方法
CN119013399A (zh) * 2022-01-26 2024-11-22 赛丹思科大学 靶向假外显子的等位基因特异性剪接转换寡核苷酸
JP7782719B2 (ja) 2022-10-28 2025-12-09 日本精工株式会社 回転支持装置、及び軸支持装置の支持機構位置調整機構
CN121712891A (zh) * 2023-06-20 2026-03-20 阿达尔克斯制药有限公司 Lrrk2调节组合物及其使用方法
AU2024353921A1 (en) * 2023-09-27 2026-04-16 Neuro3 Therapeutics (Suzhou) Ltd. Novel sirna constructs, therapeutics, and modifications
WO2025190385A1 (zh) * 2024-03-14 2025-09-18 上海拓界生物医药科技有限公司 靶向LRRK2的RNAi剂及其医药用途

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