JP2023543215A5 - - Google Patents

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Publication number
JP2023543215A5
JP2023543215A5 JP2023518754A JP2023518754A JP2023543215A5 JP 2023543215 A5 JP2023543215 A5 JP 2023543215A5 JP 2023518754 A JP2023518754 A JP 2023518754A JP 2023518754 A JP2023518754 A JP 2023518754A JP 2023543215 A5 JP2023543215 A5 JP 2023543215A5
Authority
JP
Japan
Prior art keywords
modified
nucleosides
oligonucleotide
nucleoside
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023518754A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023543215A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/051822 external-priority patent/WO2022066956A1/en
Publication of JP2023543215A publication Critical patent/JP2023543215A/ja
Publication of JP2023543215A5 publication Critical patent/JP2023543215A5/ja
Pending legal-status Critical Current

Links

JP2023518754A 2020-09-24 2021-09-23 Ａｐｏｅの発現を低減するための化合物及び方法 Pending JP2023543215A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063083006P 2020-09-24 2020-09-24
US63/083,006 2020-09-24
PCT/US2021/051822 WO2022066956A1 (en) 2020-09-24 2021-09-23 Compounds and methods for reducing apoe expression

Publications (2)

Publication Number Publication Date
JP2023543215A JP2023543215A (ja) 2023-10-13
JP2023543215A5 true JP2023543215A5 (https=) 2024-10-21

Family

ID=80846882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023518754A Pending JP2023543215A (ja) 2020-09-24 2021-09-23 Ａｐｏｅの発現を低減するための化合物及び方法

Country Status (4)

Country Link
US (1) US20230357770A1 (https=)
EP (1) EP4216964A4 (https=)
JP (1) JP2023543215A (https=)
WO (1) WO2022066956A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121013908A (zh) * 2023-02-13 2025-11-25 赛神医药有限公司 调节载脂蛋白e(apoe)表达的寡核苷酸及其使用方法
WO2025240846A1 (en) * 2024-05-17 2025-11-20 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating apoe expression

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517644B1 (en) * 1991-08-23 2009-04-14 Larry J. Smith Method and compositions for cellular reprogramming
JP2006510341A (ja) * 2002-02-27 2006-03-30 バイエル・ヘルスケア・アクチェンゲゼルシャフト 有害薬剤反応および薬剤効力を予測する単一ヌクレオチド多型
US10472634B2 (en) * 2014-06-04 2019-11-12 Ionis Pharmaceuticals, Inc. Antisense compounds targeting apolipoprotein E receptor 2
EP3191578B1 (en) * 2014-09-12 2020-11-04 Whitehead Institute for Biomedical Research Cells expressing apolipoprotein e and uses thereof
ES3039647T3 (en) * 2017-05-31 2025-10-23 Arcturus Therapeutics Inc Synthesis and structure of high potency rna therapeutics
US10517889B2 (en) * 2017-09-08 2019-12-31 Ionis Pharmaceuticals, Inc. Modulators of SMAD7 expression
AU2020227824B2 (en) * 2019-02-27 2025-07-10 Ionis Pharmaceuticals, Inc. Modulators of MALAT1 expression
EP3997227A1 (en) * 2019-07-10 2022-05-18 Locanabio, Inc. Rna-targeting knockdown and replacement compositions and methods for use
CN110257510A (zh) * 2019-08-06 2019-09-20 江苏贝格尔生物医药有限公司 一种检测apoe基因多态性的引物和探针及试剂盒
IL297702A (en) * 2020-04-27 2022-12-01 Alnylam Pharmaceuticals Inc Apolipoprotein e (apoe) irna agent compositions and methods of use thereof

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