JP2022518384A5 - - Google Patents

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Publication number
JP2022518384A5
JP2022518384A5 JP2021540037A JP2021540037A JP2022518384A5 JP 2022518384 A5 JP2022518384 A5 JP 2022518384A5 JP 2021540037 A JP2021540037 A JP 2021540037A JP 2021540037 A JP2021540037 A JP 2021540037A JP 2022518384 A5 JP2022518384 A5 JP 2022518384A5
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JP
Japan
Prior art keywords
rnai agent
nucleotide
agent according
modified
sense strand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021540037A
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English (en)
Japanese (ja)
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JP7808963B2 (ja
JP2022518384A (ja
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Priority claimed from PCT/US2020/012775 external-priority patent/WO2020146521A2/en
Publication of JP2022518384A publication Critical patent/JP2022518384A/ja
Publication of JP2022518384A5 publication Critical patent/JP2022518384A5/ja
Application granted granted Critical
Publication of JP7808963B2 publication Critical patent/JP7808963B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2021540037A 2019-01-09 2020-01-08 HIF-2アルファ(EPAS1)の発現を阻害するためのRNAi剤、その組成物及び使用方法 Active JP7808963B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962790360P 2019-01-09 2019-01-09
US62/790,360 2019-01-09
US201962827564P 2019-04-01 2019-04-01
US62/827,564 2019-04-01
US201962839381P 2019-04-26 2019-04-26
US62/839,381 2019-04-26
PCT/US2020/012775 WO2020146521A2 (en) 2019-01-09 2020-01-08 Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use

Publications (3)

Publication Number Publication Date
JP2022518384A JP2022518384A (ja) 2022-03-15
JP2022518384A5 true JP2022518384A5 (enExample) 2023-01-20
JP7808963B2 JP7808963B2 (ja) 2026-01-30

Family

ID=71520182

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021540037A Active JP7808963B2 (ja) 2019-01-09 2020-01-08 HIF-2アルファ(EPAS1)の発現を阻害するためのRNAi剤、その組成物及び使用方法

Country Status (14)

Country Link
US (1) US12221610B2 (enExample)
EP (1) EP3908288A4 (enExample)
JP (1) JP7808963B2 (enExample)
KR (1) KR20210113273A (enExample)
CN (1) CN113613661B (enExample)
AU (1) AU2020207050A1 (enExample)
BR (1) BR112021013362A2 (enExample)
CA (1) CA3120580A1 (enExample)
IL (1) IL284696A (enExample)
MX (1) MX2021008261A (enExample)
SG (1) SG11202105577TA (enExample)
TW (1) TW202043470A (enExample)
UY (1) UY38539A (enExample)
WO (1) WO2020146521A2 (enExample)

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WO2022056273A1 (en) * 2020-09-11 2022-03-17 Arrowhead Pharmaceuticals, Inc. Lipid conjugates for the delivery of therapeutic agents
WO2022056269A1 (en) * 2020-09-11 2022-03-17 Arrowhead Pharmaceuticals, Inc. Skeletal muscle delivery platforms and methods of use
WO2022086882A1 (en) 2020-10-21 2022-04-28 Nikang Therapeutics, Inc. Diagnostic and therapeutic methods for treatment of cancer with a hif-2(alpha) inhibitor
CN115105607B (zh) * 2021-03-22 2024-12-20 成都科岭源医药技术有限公司 一种用于adc的双药-接头的制备方法及其用途
CN113304274B (zh) * 2021-04-23 2025-03-04 天津全和诚生物技术有限公司 缀合物及其制备方法和用途
WO2023038027A1 (ja) * 2021-09-07 2023-03-16 国立大学法人京都大学 セノリシス薬のスクリーニング方法及びセノリシス薬

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