JP2022514344A5 - - Google Patents

Info

Publication number
JP2022514344A5
JP2022514344A5 JP2021535539A JP2021535539A JP2022514344A5 JP 2022514344 A5 JP2022514344 A5 JP 2022514344A5 JP 2021535539 A JP2021535539 A JP 2021535539A JP 2021535539 A JP2021535539 A JP 2021535539A JP 2022514344 A5 JP2022514344 A5 JP 2022514344A5
Authority
JP
Japan
Prior art keywords
compound
mmol
formula
ethyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021535539A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022514344A (ja
JP7494181B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/067088 external-priority patent/WO2020132014A1/en
Publication of JP2022514344A publication Critical patent/JP2022514344A/ja
Publication of JP2022514344A5 publication Critical patent/JP2022514344A5/ja
Priority to JP2024083009A priority Critical patent/JP7724911B2/ja
Application granted granted Critical
Publication of JP7494181B2 publication Critical patent/JP7494181B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021535539A 2018-12-19 2019-12-18 置換３－（（３－アミノフェニル）アミノ）ピペリジン－２，６－ジオン化合物、その組成物、及びそれを用いた治療方法 Active JP7494181B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024083009A JP7724911B2 (ja) 2018-12-19 2024-05-22 置換３－（（３－アミノフェニル）アミノ）ピペリジン－２，６－ジオン化合物、その組成物、及びそれを用いた治療方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862782298P 2018-12-19 2018-12-19
US62/782,298 2018-12-19
US201962879900P 2019-07-29 2019-07-29
US62/879,900 2019-07-29
PCT/US2019/067088 WO2020132014A1 (en) 2018-12-19 2019-12-18 Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024083009A Division JP7724911B2 (ja) 2018-12-19 2024-05-22 置換３－（（３－アミノフェニル）アミノ）ピペリジン－２，６－ジオン化合物、その組成物、及びそれを用いた治療方法

Publications (3)

Publication Number Publication Date
JP2022514344A JP2022514344A (ja) 2022-02-10
JP2022514344A5 true JP2022514344A5 (https=) 2023-01-20
JP7494181B2 JP7494181B2 (ja) 2024-06-03

Family

ID=71098067

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021535539A Active JP7494181B2 (ja) 2018-12-19 2019-12-18 置換３－（（３－アミノフェニル）アミノ）ピペリジン－２，６－ジオン化合物、その組成物、及びそれを用いた治療方法
JP2024083009A Active JP7724911B2 (ja) 2018-12-19 2024-05-22 置換３－（（３－アミノフェニル）アミノ）ピペリジン－２，６－ジオン化合物、その組成物、及びそれを用いた治療方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024083009A Active JP7724911B2 (ja) 2018-12-19 2024-05-22 置換３－（（３－アミノフェニル）アミノ）ピペリジン－２，６－ジオン化合物、その組成物、及びそれを用いた治療方法

Country Status (29)

Country Link
US (3) US11149007B2 (https=)
EP (2) EP4494711A3 (https=)
JP (2) JP7494181B2 (https=)
KR (2) KR102866144B1 (https=)
CN (2) CN113453681B (https=)
AU (1) AU2019403207B2 (https=)
BR (1) BR112021011968A2 (https=)
CA (1) CA3124130A1 (https=)
CL (1) CL2021001665A1 (https=)
CO (1) CO2021007973A2 (https=)
DK (1) DK3897636T3 (https=)
ES (1) ES3009308T3 (https=)
FI (1) FI3897636T3 (https=)
HR (1) HRP20250095T1 (https=)
HU (1) HUE070506T2 (https=)
IL (1) IL284223B2 (https=)
LT (1) LT3897636T (https=)
MX (1) MX2021007473A (https=)
MY (1) MY205718A (https=)
PE (1) PE20212247A1 (https=)
PL (1) PL3897636T3 (https=)
PT (1) PT3897636T (https=)
RS (1) RS66556B1 (https=)
SG (1) SG11202106507RA (https=)
SI (1) SI3897636T1 (https=)
SM (1) SMT202500111T1 (https=)
TW (1) TWI820276B (https=)
WO (1) WO2020132014A1 (https=)
ZA (1) ZA202104200B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113473987B (zh) 2018-12-19 2024-09-03 细胞基因公司 被取代的3-((3-氨基苯基)氨基)哌啶-2,6-二酮化合物、其组合物和使用其的治疗方法
CN113453681B (zh) * 2018-12-19 2024-10-11 细胞基因公司 经取代的3-((3-氨基苯基)氨基)哌啶-2，6-二酮化合物、其组合物及使用它们的治疗方法
AU2020405129A1 (en) 2019-12-19 2022-06-23 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
CR20220630A (es) 2020-05-09 2023-01-23 Arvinas Operations Inc Métodos para fabricar un compuesto bifuncional, formas ultrapuras del compuesto bifuncional y formas de dosificación que comprenden el mismo
KR20230027066A (ko) * 2020-06-24 2023-02-27 셀진 코포레이션 세레블론 결합 화합물, 이의 조성물, 및 이에 의한 치료 방법
JP7778095B2 (ja) * 2020-06-24 2025-12-01 セルジーン コーポレーション セレブロン結合化合物、その組成物及びそれによる治療方法
KR20230027214A (ko) 2020-06-24 2023-02-27 셀진 코포레이션 세레블론 결합 화합물, 이의 조성물, 및 이에 의한 치료 방법
AU2021311245A1 (en) * 2020-07-21 2023-03-09 Ubix Therapeutics, Inc. Compound for androgen receptor degradation, and pharmaceutical use thereof
US20240025863A1 (en) 2020-09-16 2024-01-25 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
WO2022087335A1 (en) 2020-10-23 2022-04-28 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
CN117203196A (zh) 2020-12-14 2023-12-08 拜欧斯瑞克斯公司 Pde4降解剂、药物组合物和治疗应用
BR112023018839A2 (pt) * 2021-03-17 2023-12-26 Medshine Discovery Inc Composto de glutarimida substituído por anel fundido com furano
KR20240026946A (ko) * 2021-06-25 2024-02-29 셀진 코포레이션 세레블론 결합 화합물, 이의 조성물, 및 이에 의한 치료 방법
WO2022272061A1 (en) * 2021-06-25 2022-12-29 Celgene Corporation Cereblon binding compounds, compositions thereof, and methods of treatment therewith
CN117561249A (zh) * 2021-06-25 2024-02-13 细胞基因公司 Cereblon结合化合物、其组合物及其用于治疗的方法
US12419962B2 (en) 2022-03-16 2025-09-23 Biotheryx, Inc. Quinazolines, pharmaceutical compositions, and therapeutic applications
CN120152718A (zh) * 2022-11-09 2025-06-13 百时美施贵宝公司 用取代的3-((3-氨基苯基)氨基)哌啶-2,6-二酮化合物的组合疗法
TW202535392A (zh) 2023-12-08 2025-09-16 美商亞文納營運公司 使用雄性素受體降解劑治療脊髓延髓性肌肉萎縮
WO2025235600A1 (en) * 2024-05-07 2025-11-13 Bristol-Myers Squibb Company Processes for the preparation of substituted 3-((3-aminophenyl)amino) piperidine-2,6-dione compounds
WO2025235577A1 (en) 2024-05-09 2025-11-13 Bristol-Myers Squibb Company Forms and formulations of substituted 3-((3-amino)piperidine-2,6-dione compounds
CN118993935B (zh) * 2024-10-23 2025-02-14 江苏恒瑞医药股份有限公司 咪唑啉衍生物或其盐的制备方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4302485A1 (de) 1993-01-29 1994-08-04 Merck Patent Gmbh Piperazinderivate
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
FR2768728B1 (fr) 1997-09-19 1999-12-03 Rhodia Chimie Sa Procede d'acylation d'un compose aromatique
FR2768729A1 (fr) 1997-09-19 1999-03-26 Rhodia Chimie Sa Procede d'acylation d'un compose aromatique et complexes catalytiques
US7629360B2 (en) 1999-05-07 2009-12-08 Celgene Corporation Methods for the treatment of cachexia and graft v. host disease
US8470829B2 (en) * 2004-09-09 2013-06-25 Chugai Seiyaku Kabushiki Kaisha Imidazolidine derivative and use thereof
WO2007073432A2 (en) 2005-10-11 2007-06-28 Chemocentryx, Inc. Piperidine derivatives and methods of use
US20080064876A1 (en) * 2006-05-16 2008-03-13 Muller George W Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
RU2434851C1 (ru) 2010-07-22 2011-11-27 Александр Васильевич Иващенко Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
US8765978B2 (en) 2010-12-16 2014-07-01 Transitions Optical, Inc. Method of making indeno-fused naphthol materials
EP2683694B1 (en) * 2011-03-10 2016-04-27 Suzhou Kintor Pharmaceuticals, Inc. Androgen receptor antagonists and uses thereof
US20140112922A1 (en) 2011-03-28 2014-04-24 Cornell University Targeted protein silencing using chimeras between antibodies and ubiquitination enzymes
KR102668696B1 (ko) 2012-01-12 2024-05-29 예일 유니버시티 E3 유비퀴틴 리가아제에 의한 표적 단백질 및 다른 폴리펩티드의 증진된 분해를 위한 화합물 및 방법
WO2014036897A1 (zh) * 2012-09-04 2014-03-13 上海恒瑞医药有限公司 咪唑啉类衍生物、其制备方法及其在医药上的应用
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
RU2683788C2 (ru) 2013-01-31 2019-04-02 Вертекс Фармасьютикалз Инкорпорейтед Амиды хинолина и хиназолина, полезные в качестве модуляторов натриевых каналов
RU2738833C9 (ru) 2014-04-14 2022-02-28 Арвинас, Оперэйшнз, Инк. Имидные модуляторы протеолиза и способы их применения
US20160058872A1 (en) 2014-04-14 2016-03-03 Arvinas, Inc. Imide-based modulators of proteolysis and associated methods of use
RU2557235C1 (ru) * 2014-07-08 2015-07-20 Александр Васильевич Иващенко Замещенные 2-тиоксо-имидазолидин-4-оны и их спироаналоги, противораковый активный компонент, фармацевтическая композиция, лекарственный препарат, способ лечения рака простаты
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
JP6817962B2 (ja) 2015-01-20 2021-01-20 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． ターゲティングされたアンドロゲン受容体分解のための化合物および方法
EP3270917A4 (en) 2015-03-18 2018-08-08 Arvinas, Inc. Compounds and methods for the enhanced degradation of targeted proteins
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
EP3319944A4 (en) 2015-07-10 2019-04-24 Arvinas, Inc. MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS
US10772962B2 (en) 2015-08-19 2020-09-15 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN110167556A (zh) 2016-07-08 2019-08-23 詹森药业有限公司 用于治疗癌症的硫代乙内酰脲雄性激素受体拮抗剂
TWI739888B (zh) 2016-10-07 2021-09-21 美商陶氏農業科學公司 農藥組合物及方法
CN110506039A (zh) 2016-10-11 2019-11-26 阿尔维纳斯股份有限公司 用于雄激素受体靶向降解的化合物和方法
US10925868B2 (en) 2016-11-10 2021-02-23 Dana-Farber Cancer Institute, Inc. Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use
WO2018098280A1 (en) 2016-11-22 2018-05-31 Dana-Farber Cancer Institute, Inc. Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use
AU2017378943B2 (en) 2016-12-19 2020-06-18 Abbisko Therapeutics Co., Ltd. FGFR4 inhibitor, preparation method therefor and pharmaceutical use thereof
IL312367A (en) 2017-01-31 2024-06-01 Arvinas Operations Inc Cereblon ligands and bifunctional compounds comprising the same
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
CN109422725A (zh) 2017-09-04 2019-03-05 北京美倍他药物研究有限公司 前列腺癌治疗药物
ES2959954T3 (es) 2017-11-28 2024-02-29 Aarti Pharmalabs Ltd Proceso para la preparación de enzalutamida utilizando un nuevo intermedio
EP3720281A4 (en) 2017-12-05 2021-05-26 Dow Agrosciences LLC PESTICIDE COMPOSITIONS AND PROCEDURES
CN114835729B (zh) 2018-05-30 2024-05-31 江苏豪森药业集团有限公司 含三并环类衍生物抑制剂、其制备方法和应用
CN109651256A (zh) 2018-11-20 2019-04-19 上海健康医学院 一种式（viii）的恩杂鲁胺的制备方法
CN113453681B (zh) * 2018-12-19 2024-10-11 细胞基因公司 经取代的3-((3-氨基苯基)氨基)哌啶-2，6-二酮化合物、其组合物及使用它们的治疗方法
CN113473987B (zh) 2018-12-19 2024-09-03 细胞基因公司 被取代的3-((3-氨基苯基)氨基)哌啶-2,6-二酮化合物、其组合物和使用其的治疗方法

Similar Documents

Publication Publication Date Title
JP2022514344A5 (https=)
AU2015282127B2 (en) Method for producing fused heterocyclic compound
TWI460166B (zh) 製備２-亞胺基-四氫噻唑-４-酮衍生物之新穎方法
US20080064876A1 (en) Process for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CN103108869A (zh) 制备氨基苯甲酰基苯并呋喃衍生物的方法
JP2020517677A5 (https=)
EP2903614A2 (en) Novel compounds, their synthesis and their uses
RU2473538C2 (ru) СПОСОБ ПОЛУЧЕНИЯ (S)-(-)-2-(N-ПРОПИЛАМИНО)-5-МЕТОКСИТЕТРАЛИНА И (S)-(-)-2-(N-ПРОПИЛАМИНО)-5-ГИДРОКСИТЕТРАЛИНА, ИХ СОЛИ С N-(3,5-ДИНИТРОБЕНЗОИЛ)-α-ФЕНИЛГЛИЦИНОМ, СПОСОБ ПОЛУЧЕНИЯ (6S)-(-)-5,6,7,8-ТЕТРАГИДРО-6-[ПРОПИЛ(2-ТИЕНИЛ)ЭТИЛ]АМИНО-1-НАФТОЛА (РОТИГОТИНА) (ВАРИАНТЫ)
JP2018506541A (ja) Ｎｅｐ阻害剤を調製するための方法および中間体
DD298911A5 (de) Azetidine, ihre herstellung und verwendung als zwischenprodukte fuer die herstellung von biologisch wirksamen substanzen
JP7292517B2 (ja) オキセタン－２－イルメタンアミンの調製のためのプロセスおよび中間体
KR101744046B1 (ko) 실로도신 합성에 유용한 중간체의 제조방법
JP5417384B2 (ja) 含ハロゲンカルバマート基とアシル基を有するエチレンジアミン誘導体の製造方法、及びそれらの製造中間体
US7381821B2 (en) Piperazine derivatives and their use as synthesis intermediates
CN116410128A (zh) 一锅法制备甲苯磺酸艾多沙班中间体的方法
KR102719583B1 (ko) 테리플루노미드의 신규한 제조 공정
JP5204438B2 (ja) 含フッ素アミン化合物の製造方法
US10189804B2 (en) Method for producing dicarboxylic acid compound
EP2141156A1 (en) Process for Preparation of Citalopram and Enantiomers
US20250145579A1 (en) Process for manufacturing an lpxc analog
EA046640B1 (ru) Способ и промежуточное соединение для получения оксетан-2-илметанамина
WO2014132994A1 (ja) 含窒素複素環誘導体の製造方法およびその製造中間体
WO2025206106A1 (ja) ３－フェニルシクロヘキセノン化合物及びその誘導体の製造方法
KR20230032513A (ko) 카모스타트 메실산염의 제조방법
FR2784990A1 (fr) Procede pour la preparation du 3-[n-[4-[4-(aminoiminomethyl) phenyl]-1,3-thiazol-2-yl]-n-(1-ethoxycarbonylmethylpiperidin -4-yl)amino] propionate d'ethyle