JP7292517B2 - オキセタン-2-イルメタンアミンの調製のためのプロセスおよび中間体 - Google Patents
オキセタン-2-イルメタンアミンの調製のためのプロセスおよび中間体 Download PDFInfo
- Publication number
- JP7292517B2 JP7292517B2 JP2022534655A JP2022534655A JP7292517B2 JP 7292517 B2 JP7292517 B2 JP 7292517B2 JP 2022534655 A JP2022534655 A JP 2022534655A JP 2022534655 A JP2022534655 A JP 2022534655A JP 7292517 B2 JP7292517 B2 JP 7292517B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- mixture
- solution
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Description
vi.式:
式VIIの化合物および式:
式:
またはその塩を生成するステップと、
vii.ステップ(vi)から得られた化合物に対して環化反応を実行して、式:
場合により反応させて、その薬学的に許容される塩を形成するステップと、をさらに含んでもよい。
場合により反応させて、その薬学的に許容される塩を形成するステップ(本明細書中、ステップ(viii))をさらに含んでもよい。
(R)-1-クロロ-3-(ジベンジルアミノ)プロパン-2-オール
(R)-N,N-ジベンジル-1-(オキシラン-2-イル)メタンアミン
(S)-N,N-ジベンジル-1-(オキセタン-2-イル)メタンアミン
(S)-オキセタン-2-イルメタンアミン塩酸塩
(S)-オキセタン-2-イルメタンアミン
(S)-4-ニトロ-3-((オキセタン-2-イルメチル)アミノ)安息香酸メチル
(S)-4-ニトロ-3-((オキセタン-2-イルメチル)アミノ)安息香酸
(S)-4-アミノ-3-((オキセタン-2-イルメチル)アミノ)安息香酸
(S)-4-(2-(4-(6-((4-シアノ-2-フルオロベンジル)オキシ)ピリジン-2-イル)-2-フルオロ-5-メチルフェニル)アセトアミド)-3-((オキセタン-2-イルメチル)アミノ)安息香酸
(4-ブロモ-2-フルオロ-5-メチルフェニル)メタノール
2-(4-ブロモ-2-フルオロ-5-メチルフェニル)アセトニトリル
メチル2-(4-ブロモ-2-フルオロ-5-メチル-フェニル)アセテート
メチル2-[2-フルオロ-4-(6-ヒドロキシ-2-ピリジル)-5-メチル-フェニル]アセテート
メチル2-[4-[6-[(4-シアノ-2-フルオロ-フェニル)メトキシ]-2-ピリジル]-2-フルオロ-5-メチル-フェニル]アセテート
2-[4-[6-[(4-シアノ-2-フルオロ-フェニル)メトキシ]-2-ピリジル]-2-フルオロ-5-メチル-フェニル]酢酸
tert-ブチルアンモニウム;2-[[4-[6-[(4-シアノ-2-フルオロ-フェニル)メトキシ]-2-ピリジル]-2-フルオロ-5-メチル-フェニル]メチル]-3-[[(2S)-オキセタン-2-イル]メチル]ベンズイミダゾール-5-カルボキシレート
Claims (13)
- 前記ハロゲン化トリメチルスルフキソニウムが、ヨウ化トリメチルスルフキソニウムである、請求項1または2に記載のプロセス。
- ステップ(ii)の前記塩基が、カリウムtert-ブトキシドである、請求項1~3のいずれか一項に記載のプロセス。
- ステップ(ii)の前記溶液が、tert-ブタノールである溶媒を含む、請求項1~4のいずれか一項に記載のプロセス。
- Rが、HまたはC1-4アルキルである、請求項6に記載のプロセス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962946146P | 2019-12-10 | 2019-12-10 | |
US62/946,146 | 2019-12-10 | ||
PCT/US2020/063546 WO2021118906A1 (en) | 2019-12-10 | 2020-12-07 | Process and intermediate for the preparation of oxetan-2-ylmethanamine |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2023504581A JP2023504581A (ja) | 2023-02-03 |
JP7292517B2 true JP7292517B2 (ja) | 2023-06-16 |
Family
ID=74003942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022534655A Active JP7292517B2 (ja) | 2019-12-10 | 2020-12-07 | オキセタン-2-イルメタンアミンの調製のためのプロセスおよび中間体 |
Country Status (26)
Country | Link |
---|---|
US (1) | US20230013840A1 (ja) |
EP (1) | EP4073051B1 (ja) |
JP (1) | JP7292517B2 (ja) |
KR (1) | KR102635237B1 (ja) |
CN (1) | CN114728923A (ja) |
AU (1) | AU2020401539B2 (ja) |
BR (1) | BR112022008892A2 (ja) |
CA (1) | CA3160419A1 (ja) |
CL (1) | CL2022001511A1 (ja) |
CO (1) | CO2022008127A2 (ja) |
DK (1) | DK4073051T3 (ja) |
EC (1) | ECSP22046595A (ja) |
ES (1) | ES2975599T3 (ja) |
FI (1) | FI4073051T3 (ja) |
HR (1) | HRP20240343T1 (ja) |
IL (1) | IL292707A (ja) |
LT (1) | LT4073051T (ja) |
MA (1) | MA58104B1 (ja) |
MX (1) | MX2022006984A (ja) |
PE (1) | PE20230183A1 (ja) |
PL (1) | PL4073051T3 (ja) |
PT (1) | PT4073051T (ja) |
RS (1) | RS65238B1 (ja) |
SI (1) | SI4073051T1 (ja) |
UA (1) | UA127884C2 (ja) |
WO (1) | WO2021118906A1 (ja) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040265236A1 (en) | 2003-02-19 | 2004-12-30 | Heiko Schirmer | Trimeric macrocyclic substituted benzene derivatives |
JP2014513115A (ja) | 2011-05-06 | 2014-05-29 | エギシュ ヂョヂセルヂャール ニルヴァーノサン ミケデ レースヴェーニタールササーグ | リバロキサバンの製法及び該方法において形成される中間体 |
JP2015520750A (ja) | 2012-05-09 | 2015-07-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | オキセタン−3−イルメタンアミンの製造方法 |
WO2018109607A1 (en) | 2016-12-16 | 2018-06-21 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
CN109265389A (zh) | 2018-08-31 | 2019-01-25 | 南京富润凯德生物医药有限公司 | 2-(氨基甲基)-1-氧杂-7-氮杂螺[3.5]壬烷衍生物、中间体及其制备方法 |
-
2020
- 2020-12-07 WO PCT/US2020/063546 patent/WO2021118906A1/en active Application Filing
- 2020-12-07 RS RS20240243A patent/RS65238B1/sr unknown
- 2020-12-07 CN CN202080082957.9A patent/CN114728923A/zh active Pending
- 2020-12-07 PL PL20829133.6T patent/PL4073051T3/pl unknown
- 2020-12-07 PT PT208291336T patent/PT4073051T/pt unknown
- 2020-12-07 FI FIEP20829133.6T patent/FI4073051T3/fi active
- 2020-12-07 MX MX2022006984A patent/MX2022006984A/es unknown
- 2020-12-07 AU AU2020401539A patent/AU2020401539B2/en active Active
- 2020-12-07 ES ES20829133T patent/ES2975599T3/es active Active
- 2020-12-07 LT LTEPPCT/US2020/063546T patent/LT4073051T/lt unknown
- 2020-12-07 IL IL292707A patent/IL292707A/en unknown
- 2020-12-07 PE PE2022001046A patent/PE20230183A1/es unknown
- 2020-12-07 EP EP20829133.6A patent/EP4073051B1/en active Active
- 2020-12-07 UA UAA202201389A patent/UA127884C2/uk unknown
- 2020-12-07 JP JP2022534655A patent/JP7292517B2/ja active Active
- 2020-12-07 BR BR112022008892A patent/BR112022008892A2/pt unknown
- 2020-12-07 DK DK20829133.6T patent/DK4073051T3/da active
- 2020-12-07 MA MA58104A patent/MA58104B1/fr unknown
- 2020-12-07 CA CA3160419A patent/CA3160419A1/en active Pending
- 2020-12-07 KR KR1020227018626A patent/KR102635237B1/ko active IP Right Grant
- 2020-12-07 US US17/779,447 patent/US20230013840A1/en active Pending
- 2020-12-07 HR HRP20240343TT patent/HRP20240343T1/hr unknown
- 2020-12-07 SI SI202030381T patent/SI4073051T1/sl unknown
-
2022
- 2022-06-08 CO CONC2022/0008127A patent/CO2022008127A2/es unknown
- 2022-06-08 CL CL2022001511A patent/CL2022001511A1/es unknown
- 2022-06-10 EC ECSENADI202246595A patent/ECSP22046595A/es unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040265236A1 (en) | 2003-02-19 | 2004-12-30 | Heiko Schirmer | Trimeric macrocyclic substituted benzene derivatives |
JP2014513115A (ja) | 2011-05-06 | 2014-05-29 | エギシュ ヂョヂセルヂャール ニルヴァーノサン ミケデ レースヴェーニタールササーグ | リバロキサバンの製法及び該方法において形成される中間体 |
JP2015520750A (ja) | 2012-05-09 | 2015-07-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | オキセタン−3−イルメタンアミンの製造方法 |
WO2018109607A1 (en) | 2016-12-16 | 2018-06-21 | Pfizer Inc. | Glp-1 receptor agonists and uses thereof |
CN109265389A (zh) | 2018-08-31 | 2019-01-25 | 南京富润凯德生物医药有限公司 | 2-(氨基甲基)-1-氧杂-7-氮杂螺[3.5]壬烷衍生物、中间体及其制备方法 |
Non-Patent Citations (2)
Title |
---|
ACS Catalysis,2022年10月12日,12(20),13042-13049,doi 10.1021/acscatal.2c03583 |
Tetrahedron Letters,1996年,37(2),245-248,DOI 10.1016/0040-4039(95)02139-6 |
Also Published As
Publication number | Publication date |
---|---|
CA3160419A1 (en) | 2021-06-17 |
AU2020401539B2 (en) | 2023-06-01 |
EP4073051A1 (en) | 2022-10-19 |
JP2023504581A (ja) | 2023-02-03 |
UA127884C2 (uk) | 2024-01-31 |
MX2022006984A (es) | 2022-07-13 |
ECSP22046595A (es) | 2022-07-29 |
FI4073051T3 (fi) | 2024-03-28 |
KR20220097941A (ko) | 2022-07-08 |
SI4073051T1 (sl) | 2024-04-30 |
HRP20240343T1 (hr) | 2024-05-24 |
PT4073051T (pt) | 2024-02-21 |
CL2022001511A1 (es) | 2023-01-20 |
ES2975599T3 (es) | 2024-07-09 |
PE20230183A1 (es) | 2023-02-01 |
LT4073051T (lt) | 2024-03-12 |
AU2020401539A1 (en) | 2022-06-16 |
BR112022008892A2 (pt) | 2022-08-23 |
RS65238B1 (sr) | 2024-03-29 |
MA58104B1 (fr) | 2024-05-31 |
CO2022008127A2 (es) | 2022-06-10 |
IL292707A (en) | 2022-07-01 |
PL4073051T3 (pl) | 2024-05-20 |
US20230013840A1 (en) | 2023-01-19 |
EP4073051B1 (en) | 2024-02-07 |
CN114728923A (zh) | 2022-07-08 |
WO2021118906A1 (en) | 2021-06-17 |
DK4073051T3 (da) | 2024-02-26 |
KR102635237B1 (ko) | 2024-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7309803B2 (en) | Clean, High-yield preparation of S,S and R,S amino acid isosteres | |
US9643927B1 (en) | Process for the preparation of kinase inhibitors and intermediates thereof | |
AU2014339136B2 (en) | Process for the preparation of a PDE4 inhibitor | |
JP6832946B2 (ja) | キナーゼ阻害剤およびその中間体の調製方法 | |
JP7287978B2 (ja) | 二つの4-{[(2s)-2-{4-[5-クロロ-2-(1h-1,2,3-トリアゾール-1-イル)フェニル]-5-メトキシ-2-オキソピリジン-1(2h)-イル}ブタノイル]アミノ}-2-フルオロベンズアミド誘導体の調製方法 | |
JP6873053B2 (ja) | タンパク質脱アセチル化阻害剤の製造方法 | |
JP6275881B2 (ja) | デュオカルマイシンのプロドラッグを製造するための改良された方法 | |
JP2013532164A (ja) | トロンビン特異的インヒビターを調製する方法 | |
KR20180038460A (ko) | 세포독성 벤조다이아제핀 유도체의 제조 방법 | |
WO2019058290A1 (en) | IMPROVED PROCESS FOR THE PREPARATION OF AZANIMOD A-AMINO COMPOUND | |
CN109476609B (zh) | 吡唑-酰胺化合物的制造方法 | |
RU2137769C1 (ru) | Способ получения эпоксида | |
JP7292517B2 (ja) | オキセタン-2-イルメタンアミンの調製のためのプロセスおよび中間体 | |
JP4944136B2 (ja) | 高光学純度のカルベジロールの製造方法 | |
AU2011222588B2 (en) | Process for the preparation of 2-(cyclohexylmethyl)-N-{2- [(2S)-1-methylpyrrolidin-2-yl]ethyl}-1, 2, 3, 4- tetrahydroisoquinoline-7-sulfonamide | |
WO2012041263A2 (en) | A method of manufacturing 2-({(5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]- l,3-oxazolidin-5-yl}methyl)-lh-isoindol-l,3(2h)-dione with a high optical purity | |
KR100990046B1 (ko) | 신규한 몬테루카스트 4-할로 벤질아민염 및 이를 이용한 몬테루카스트 나트륨염의 제조방법 | |
RU2804663C2 (ru) | Способ получения двух 4-{ [(2s)-2-{ 4-[5-хлор-2-(1h-1,2,3-триазол-1-ил)фенил]-5-метокси-2-оксопиридин-1(2h)-ил} бутаноил]амино} -2-фторбензамидных производных | |
TWI825323B (zh) | 用於製備2-(2,6-二氯苯基)-1-[(1s,3r)-3-(羥甲基)-5-(3-羥基-3-甲基丁基)-1-甲基-3,4-二氫異喹啉-2(1h)-基]乙烯酮之方法及中間物 | |
WO2014152768A1 (en) | Cyclohexanediamine compounds and methods for their preparation | |
KR20230032513A (ko) | 카모스타트 메실산염의 제조방법 | |
JP2022035954A (ja) | N-Boc-ラクタム誘導体及びその製造方法、並びに、環状アミン誘導体の製造方法 | |
CZ2008598A3 (cs) | Zpusob výroby (S)-N-[4-(4-acetylamino-4-fenylpiperidin-1-yl)-2-(3,4-dichlorfenyl)-butyl]-N-methylbenzamidu | |
JP2002241353A (ja) | 光学活性アミン誘導体および合成法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220608 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220608 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230530 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230606 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7292517 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |