JP2022511348A5 - - Google Patents
Info
- Publication number
- JP2022511348A5 JP2022511348A5 JP2021516750A JP2021516750A JP2022511348A5 JP 2022511348 A5 JP2022511348 A5 JP 2022511348A5 JP 2021516750 A JP2021516750 A JP 2021516750A JP 2021516750 A JP2021516750 A JP 2021516750A JP 2022511348 A5 JP2022511348 A5 JP 2022511348A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- nucleic acid
- plasmid
- seq
- upstream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024161633A JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862750603P | 2018-10-25 | 2018-10-25 | |
| US62/750,603 | 2018-10-25 | ||
| PCT/US2019/057916 WO2020086881A1 (en) | 2018-10-25 | 2019-10-24 | Aav triple-plasmid system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024161633A Division JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511348A JP2022511348A (ja) | 2022-01-31 |
| JP2022511348A5 true JP2022511348A5 (enExample) | 2022-10-19 |
| JP7560447B2 JP7560447B2 (ja) | 2024-10-02 |
Family
ID=70331899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021516750A Active JP7560447B2 (ja) | 2018-10-25 | 2019-10-24 | Ａａｖトリプルプラスミドシステム |
| JP2024161633A Pending JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024161633A Pending JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12383587B2 (enExample) |
| EP (1) | EP3870148A4 (enExample) |
| JP (2) | JP7560447B2 (enExample) |
| KR (1) | KR20210086645A (enExample) |
| CN (1) | CN112888426A (enExample) |
| AU (1) | AU2019363593A1 (enExample) |
| CA (1) | CA3112883A1 (enExample) |
| IL (1) | IL281909A (enExample) |
| TW (1) | TW202029957A (enExample) |
| WO (1) | WO2020086881A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12509492B2 (en) | 2018-01-19 | 2025-12-30 | Duke University | Genome engineering with CRISPR-Cas systems in eukaryotes |
| TWI887234B (zh) | 2019-04-14 | 2025-06-21 | 美國公爵大學 | 治療杜興氏（ｄｕｃｈｅｎｎｅ）肌肉失養症之大型突變熱點之ａａｖ載體介導之刪除 |
| US10557149B1 (en) * | 2019-07-15 | 2020-02-11 | Vigene Biosciences, Inc. | Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus |
| US20230241249A1 (en) * | 2020-07-07 | 2023-08-03 | The Board Of Regents Of The University Of Texas System | Adeno-associated virus vector for dwarf open reading frame |
| US12054738B2 (en) | 2020-07-30 | 2024-08-06 | Shape Therapeutics Inc. | Stable cell lines for inducible production of rAAV virions |
| WO2022087321A1 (en) * | 2020-10-21 | 2022-04-28 | Duke University | Dual aav vector-mediated deletion of large mutational hotspot for treatment of duchenne muscular dystrophy |
| KR20230116801A (ko) * | 2020-11-04 | 2023-08-04 | 가부시키가이샤 신프로젠 | 고초균에 있어서의 바이러스 벡터 플라스미드 생산 |
| WO2022169774A1 (en) * | 2021-02-02 | 2022-08-11 | University Of Massachusetts | Inverted terminal repeats from aav serotypes 8 and rh.39 in gene therapy vectors |
| IL307830A (en) * | 2021-04-21 | 2023-12-01 | Asimov Inc | Stable production systems for adeno-associated virus production |
| CN117897167A (zh) * | 2021-05-13 | 2024-04-16 | 福奇生物制品公司 | 腺病毒辅助质粒 |
| US12305188B2 (en) | 2021-05-27 | 2025-05-20 | Neuracle Genetics Inc. | Dual helper plasmid |
| EP4347850A4 (en) * | 2021-05-27 | 2025-04-02 | Neuracle Genetics Inc. | Novel dual helper plasmid |
| US20230055381A1 (en) * | 2021-06-25 | 2023-02-23 | Oxford Biomedica Solutions Llc | Adeno-associated virus packaging systems |
| WO2023009622A1 (en) * | 2021-07-28 | 2023-02-02 | Atsena Therapeutics, Inc. | Aav transfer plasmids |
| JP2024537133A (ja) * | 2021-10-05 | 2024-10-10 | リジェネクスバイオ インコーポレイテッド | 組換えａａｖ生成のための組成物及び方法 |
| AR127674A1 (es) | 2021-10-18 | 2024-02-21 | Regeneron Pharma | Células de mamífero que comprenden genes cas9 integrados para producir sitios de integración estables, y células de mamífero que comprenden sitios de integración estables y otros sitios |
| CN114196705B (zh) * | 2021-12-07 | 2024-09-06 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒包装质粒、重组腺相关病毒及其应用 |
| WO2023102736A1 (zh) * | 2021-12-07 | 2023-06-15 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒包装质粒、重组腺相关病毒及其应用 |
| WO2023220502A1 (en) * | 2022-05-12 | 2023-11-16 | AAVnerGene Inc. | Compositions and methods for recombinant parvovirus production |
| JP2025523458A (ja) * | 2022-06-22 | 2025-07-23 | アスクバイオ インコーポレイテッド | アデノウイルスに基づく核酸およびその方法 |
| WO2024046403A1 (zh) * | 2022-08-31 | 2024-03-07 | 江苏金斯瑞蓬勃生物科技有限公司 | 能够提高腺相关病毒滴度的腺相关病毒结构质粒 |
| CN116064672B (zh) * | 2022-09-15 | 2025-02-14 | 思鹏生物科技(苏州)有限公司 | 利用ires基因提升aav包装效率的方法及其功能基因 |
| EP4611784A2 (en) * | 2022-11-04 | 2025-09-10 | National Resilience, Inc. | Methods and compositions for preparing recombinant adeno associated viruses and uses thereof |
| WO2024160232A1 (zh) * | 2023-02-01 | 2024-08-08 | 纽福斯(苏州)生物科技有限公司 | 质粒包装系统及其应用 |
| CN116411024A (zh) * | 2023-03-10 | 2023-07-11 | 上海泰昶生物技术有限公司 | 用于生产重组腺相关病毒的质粒系统 |
| TW202446959A (zh) * | 2023-04-03 | 2024-12-01 | 美商德西貝治療公司 | 經修飾之ｒｅｐ—ｃａｐ質體及其用途 |
| WO2024238742A2 (en) * | 2023-05-16 | 2024-11-21 | Oxford Biomedica (Us) Llc | Compositions and methods for increasing aav productivity |
| CN121794376A (zh) * | 2023-09-07 | 2026-04-03 | 北京中因科技股份有限公司 | Aav载体骨架优化及应用 |
| CN117778431B (zh) * | 2023-12-04 | 2024-10-25 | 广州派真生物技术有限公司 | 一种用于重组腺相关病毒包装的质粒系统及其应用 |
| CN117925663A (zh) * | 2023-12-04 | 2024-04-26 | 广州派真生物技术有限公司 | 一种用于重组腺相关病毒包装的质粒系统及其应用 |
| CN117683796A (zh) * | 2023-12-04 | 2024-03-12 | 广州派真生物技术有限公司 | 一种用于重组腺相关病毒包装的质粒系统及其应用 |
| CN117683797B (zh) * | 2023-12-04 | 2024-07-05 | 广州派真生物技术有限公司 | 一种用于重组腺相关病毒包装的质粒系统及其应用 |
| CN121780618A (zh) * | 2023-12-13 | 2026-04-03 | 广州派真生物技术有限公司 | 一种高产重组腺相关病毒的辅助质粒及应用 |
| CN117660534B (zh) * | 2023-12-13 | 2024-05-07 | 广州派真生物技术有限公司 | 一种降低重组腺相关病毒中宿主细胞dna残留的辅助质粒及应用 |
| WO2025188755A1 (en) | 2024-03-04 | 2025-09-12 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of duchenne muscular dystrophy |
| WO2025217308A1 (en) * | 2024-04-10 | 2025-10-16 | Solid Biosciences Inc. | Method of aav production |
| WO2025226841A1 (en) | 2024-04-24 | 2025-10-30 | Kate Therapeutics, Inc. | Gene therapy approach for treating disorders associated with tnnt2 |
| WO2025226842A1 (en) | 2024-04-24 | 2025-10-30 | Kate Therapeutics, Inc. | Expression control by drg-expressed mirnas |
| WO2026011008A1 (en) | 2024-07-02 | 2026-01-08 | Kate Therapeutics, Inc. | Expression control by skeletal muscle-expressed mirnas |
| WO2026011009A1 (en) | 2024-07-02 | 2026-01-08 | Kate Therapeutics, Inc. | Compositions and methods for muscle disorders |
| WO2026019230A1 (ko) * | 2024-07-15 | 2026-01-22 | 삼성바이오에피스 주식회사 | 스터퍼를 포함하는 재조합 aav 생산을 위한 벡터 시스템 |
| WO2026030242A1 (en) | 2024-07-29 | 2026-02-05 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of facioscapulohumeral muscular dystrophy |
| WO2026030244A1 (en) | 2024-07-30 | 2026-02-05 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of limb girdle muscular dystrophy 2a |
| WO2026050402A1 (en) | 2024-08-29 | 2026-03-05 | Kate Therapeutics, Inc. | Liver de-targeted muscle tropic capsids |
| CN119662733B (zh) * | 2024-12-09 | 2025-10-28 | 广州派真生物技术有限公司 | 一种高产rAAV的质粒系统及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004797A (en) | 1995-11-09 | 1999-12-21 | Avigen, Inc. | Adenovirus helper-free recombinant AAV Virion production |
| CA2369985A1 (en) * | 2002-01-18 | 2003-07-18 | Duke University | Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach |
| US9249425B2 (en) | 2011-05-16 | 2016-02-02 | The Trustees Of The University Of Pennslyvania | Proviral plasmids and production of recombinant adeno-associated virus |
| US9163259B2 (en) * | 2012-05-04 | 2015-10-20 | Novartis Ag | Viral vectors for the treatment of retinal dystrophy |
| JP2016517278A (ja) | 2013-03-15 | 2016-06-16 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ | スタッファー／フィラーポリヌクレオチド配列を含むベクターおよびその使用方法 |
| NZ716102A (en) | 2013-07-22 | 2021-12-24 | The Children’S Hospital Of Philadelphia | Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues |
| US11078464B2 (en) * | 2013-08-30 | 2021-08-03 | Amgen Inc. | High titer recombinant AAV vector production in adherent and suspension cells |
| CN105765066B (zh) * | 2013-11-29 | 2018-12-14 | 宝生物工程株式会社 | 用于定量腺伴随病毒的方法 |
| US10307492B2 (en) * | 2014-03-11 | 2019-06-04 | Wayne State University | Modified MGLUR6 promoter and methods of use |
| EP3218503A4 (en) | 2014-11-10 | 2018-06-06 | Murdoch Childrens Research Institute | Vectors and methods for targeted integration in loci comprising constitutively expressed genes |
| CA2979120A1 (en) | 2015-03-03 | 2016-09-09 | Fondazione Telethon | Multiple aav vector system for expressing genes over 5 kilobases, comprising at least one degradation signal and uses thereof |
| AU2016260401B2 (en) | 2015-05-14 | 2022-05-19 | St. Jude Children's Research Hospital, Inc. | Nucleic acid molecules containing spacers and methods of use thereof |
| WO2016196507A1 (en) * | 2015-05-29 | 2016-12-08 | University Of Iowa Research Foundation | Methods of delivery of transgenes for treating brain diseases |
| SG11201903517RA (en) | 2016-10-31 | 2019-05-30 | Kolon Life Science Inc | Composition for alleviating or treating pain |
| BR112020020204A2 (pt) | 2018-04-05 | 2021-01-19 | Oxford University Innovation Limited | Composições e métodos para tratamento da distrofia macular |
-
2019
- 2019-10-24 EP EP19876857.4A patent/EP3870148A4/en active Pending
- 2019-10-24 AU AU2019363593A patent/AU2019363593A1/en not_active Abandoned
- 2019-10-24 US US17/288,141 patent/US12383587B2/en active Active
- 2019-10-24 KR KR1020217014276A patent/KR20210086645A/ko not_active Ceased
- 2019-10-24 WO PCT/US2019/057916 patent/WO2020086881A1/en not_active Ceased
- 2019-10-24 CN CN201980069110.4A patent/CN112888426A/zh active Pending
- 2019-10-24 CA CA3112883A patent/CA3112883A1/en active Pending
- 2019-10-24 JP JP2021516750A patent/JP7560447B2/ja active Active
- 2019-10-25 TW TW108138732A patent/TW202029957A/zh unknown
-
2021
- 2021-03-30 IL IL281909A patent/IL281909A/en unknown
-
2024
- 2024-09-19 JP JP2024161633A patent/JP2025000711A/ja active Pending
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