|
US2776926A
(en)
|
1955-08-04 |
1957-01-08 |
Eugene S Sharpe |
Preparation of alpha-ketoglutaric acid by serratia marcescens
|
|
US2917528A
(en)
|
1956-08-24 |
1959-12-15 |
Victor Chemical Works |
Alkanolaminealkanephosphonic acids and salts thereof
|
|
US2841616A
(en)
*
|
1956-10-30 |
1958-07-01 |
Campbell Soup Co |
Process for the recovery of alpha-ketoglutaric acid
|
|
US3875304A
(en)
|
1970-04-24 |
1975-04-01 |
Schlitz Brewing Co J |
Livestock feed composition and method of preparing the same
|
|
US4045585A
(en)
|
1976-05-19 |
1977-08-30 |
Decel Corporation |
Flavored animal food compositions
|
|
DE3151196A1
(de)
*
|
1981-12-23 |
1983-06-30 |
Kurt Heinz Prof. Dr. 7800 Freiburg Bauer |
Verfahren zur herstellung von gut loeslichen 5-aminosalicylsaeure-arzneimittelzubereitungen
|
|
US6451341B1
(en)
|
1990-02-05 |
2002-09-17 |
Thomas J. Slaga |
Time release formulation of vitamins, minerals and other beneficial supplements
|
|
US5646187A
(en)
|
1992-05-20 |
1997-07-08 |
Ab Erik Vinnars |
Use of alpha-ketoglutarate
|
|
US6306430B1
(en)
|
1998-04-16 |
2001-10-23 |
The Iams Company |
Process for decreasing adiposity using vitamin a as a dietary supplement
|
|
US6905707B2
(en)
|
1998-05-28 |
2005-06-14 |
Medical Research Institute |
Controlled release arginine alpha ketoglutarate
|
|
CO5140079A1
(es)
|
1998-10-14 |
2002-03-22 |
Novartis Ag |
Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo
|
|
US6649654B1
(en)
|
1999-11-23 |
2003-11-18 |
The Regents Of The University Of California |
Methods for identifying and using IKK inhibitors
|
|
US7169755B2
(en)
|
2000-12-20 |
2007-01-30 |
Alcon, Inc. |
Solution for removing cataracts via liquefracture
|
|
EP1622629B1
(en)
*
|
2003-05-07 |
2013-07-10 |
Osteologix A/S |
Controlled-release composition containing a strontium salt
|
|
EP1744770A2
(en)
*
|
2004-05-06 |
2007-01-24 |
Osteologix A/S |
High yield and rapid syntheses methods for producing metallo-organic salts
|
|
PL368572A1
(en)
*
|
2004-06-17 |
2005-12-27 |
Sgp & Sons Ab |
Pharmaceutical compound for prevention and therapy of increased level of cholesterol, ldl and triglycerides as well as application of the pharmaceutical compound as an agent acting against atherosclerosis and used in circulatory system affections
|
|
US20090005437A1
(en)
|
2004-08-09 |
2009-01-01 |
Eyal Gottlieb |
Alpha-Ketoglutarates and Their Use as Therapeutic Agents
|
|
ES2510690T3
(es)
|
2004-12-17 |
2014-10-21 |
Alan B. Cash |
Método para extender la esperanza de vida y retrasar la aparición de enfermedad relacionada con la edad
|
|
US20060234250A1
(en)
|
2005-04-15 |
2006-10-19 |
Powers Ralph W Iii |
Methods of screening and compositions for life span modulators
|
|
WO2007001883A2
(en)
|
2005-06-20 |
2007-01-04 |
Accera, Inc. |
Method to reduce oxidative damage and improve mitochondrial efficiency
|
|
US20070105942A1
(en)
|
2005-11-08 |
2007-05-10 |
Heuer Marvin A |
Supplemental dietary composition for turning on anabolic switches in muscle, stimulating and/or optimizing protein synthesis, and/or potently signaling muscle building and/or growth via molecular pathways
|
|
US8367121B2
(en)
|
2005-11-23 |
2013-02-05 |
Florida A & M University |
Nutraceutical agent for attenuating the neurodegenerative process associated with Parkinson's disease
|
|
PL379512A1
(pl)
|
2006-04-21 |
2007-10-29 |
Sgp & Sons Ab |
Nowe metody i ich zastosowanie
|
|
PL226695B1
(pl)
|
2006-07-03 |
2017-08-31 |
Danuta Kruszewska |
Środek do zastosowania w zapobieganiu i/lub hamowaniu kolonizacji Helicobacter pylori, zastosowanie soli kwasu alfa‑ketoglutarowego z metalami alkalicznymi i ziem alkalicznych do wytwarzania środka leczniczego oraz dodatku do żywności do zapobiegania i/lub hamowania kolonizacji Helicobacter pylori
|
|
NZ579340A
(en)
|
2007-03-19 |
2012-05-25 |
Metaproteomics Llc |
Methods and compositions for promoting bone and joint health comprising berberine
|
|
EP2173336B1
(en)
|
2007-07-02 |
2016-03-30 |
Protista Biotechnology AB |
Alpha-ketoglutaric acid for use in the treatment of hypertension or pulmonary hypertension
|
|
EP2033623A1
(en)
|
2007-09-07 |
2009-03-11 |
Cutech S.R.L. |
Compositions comprising ornithine ketoglutarate (OKG)
|
|
JP5406643B2
(ja)
*
|
2008-09-22 |
2014-02-05 |
日本合成化学工業株式会社 |
α−オキソカルボン酸の金属塩の製造方法
|
|
CN101759553A
(zh)
|
2008-11-21 |
2010-06-30 |
扬子江药业集团北京海燕药业有限公司 |
α-酮酸钙的制备方法
|
|
DE102009016119A1
(de)
|
2009-04-03 |
2010-10-14 |
Evonik Degussa Gmbh |
Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren zur Unterstützung der Diabetestherapie
|
|
AU2010233073B2
(en)
|
2009-04-10 |
2014-07-31 |
Haiyan Qi |
Novel anti-aging agents and methods to identify them
|
|
AU2010247800A1
(en)
|
2009-05-11 |
2011-12-15 |
Berg Llc |
Methods for the diagnosis of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
|
|
JP2012527894A
(ja)
|
2009-05-28 |
2012-11-12 |
ザ・アイムス・カンパニー |
被覆キブル形態のペットフード
|
|
AU2010258356B2
(en)
|
2009-06-12 |
2017-01-19 |
Generex Pharmaceuticals, Inc. |
Compositions and methods for prevention and treatment of brain diseases and conditions
|
|
WO2011000218A1
(en)
|
2009-06-30 |
2011-01-06 |
Shuen-Lu Huang |
Compositions containing berberine or analogs thereof for treating rosacea or red face related skin disorders
|
|
WO2011060305A1
(en)
|
2009-11-12 |
2011-05-19 |
Nox Technologies, Inc. |
Potato skin compositions that lower cytosolic nadh level to mimic calorie restriction
|
|
WO2012114204A2
(en)
|
2011-02-15 |
2012-08-30 |
Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto |
Methods of treating mitochondrial dysfunction
|
|
CN103491804A
(zh)
|
2011-04-18 |
2014-01-01 |
雀巢产品技术援助有限公司 |
具有α-HICA 和二十碳五烯酸的营养组合物
|
|
US9248185B2
(en)
|
2011-06-16 |
2016-02-02 |
President And Fellows Of Harvard College |
Methods of increasing satellite cell proliferation
|
|
CN102586347B
(zh)
*
|
2012-03-06 |
2014-04-09 |
江南大学 |
一种两阶段pH控制高产a-酮戊二酸的方法
|
|
US9532997B2
(en)
|
2012-04-03 |
2017-01-03 |
Whitehead Institute For Biomedical Research |
Compositions and methods for promoting intestinal stem cell function
|
|
ITBO20120226A1
(it)
|
2012-04-24 |
2013-10-25 |
Alfa Wassermann Spa |
Composizioni comprendenti ornitina alfa-chetoglutarato, processi per il loro ottenimento e il loro uso.
|
|
JP6029058B2
(ja)
*
|
2012-09-14 |
2016-11-24 |
国立研究開発法人農業・食品産業技術総合研究機構 |
シュウ酸カルシウムを含む氷核活性剤
|
|
FI3398594T3
(en)
|
2012-09-19 |
2024-09-23 |
Grespo Ab |
Compositions for improvement of brain function
|
|
CN102976927A
(zh)
*
|
2012-12-26 |
2013-03-20 |
天津天成制药有限公司 |
α-酮戊二酸钙的制备方法
|
|
CA2896646A1
(en)
|
2012-12-27 |
2014-07-03 |
Hayashibara Co., Ltd. |
Skin-exterior anti-ageing composition and production method therefor
|
|
WO2014116985A1
(en)
|
2013-01-25 |
2014-07-31 |
Winning The Fight Inc. |
Composition for treatment of neurodegenerative disease
|
|
US9511057B2
(en)
|
2013-03-15 |
2016-12-06 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for treating denervation-induced muscle atrophy
|
|
CA2902603C
(en)
|
2013-03-19 |
2021-03-02 |
University Of South Florida |
Compositions and methods for producing elevated and sustained ketosis
|
|
US20160263092A1
(en)
|
2013-12-19 |
2016-09-15 |
Twi Biotechnology, Inc. |
Therapeutic uses of berberine formulations
|
|
CN106163513A
(zh)
|
2014-02-12 |
2016-11-23 |
加利福尼亚大学董事会 |
用于治疗衰老和与年龄相关的疾病和症状的组合物和方法
|
|
WO2015171723A1
(en)
|
2014-05-06 |
2015-11-12 |
Research Development Foundation |
Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy
|
|
CA2953387C
(en)
|
2014-06-30 |
2023-11-28 |
The Regents Of The University Of California |
Ketobutyrate compounds and compositions for treating age-related symptoms and diseases
|
|
CA2945609C
(en)
|
2014-07-29 |
2023-05-23 |
Shenzhen Hightide Biopharmaceutical, Ltd. |
Berberine-ursodeoxycholic salt, method of preparation and application therof
|
|
US20170266253A1
(en)
|
2014-07-31 |
2017-09-21 |
Indiana University Research And Technology Corporation |
Antithetical regulation of endothelial ace and ace2 by brg1-foxm1 complex underlies pathological cardiac hypertrophy
|
|
CN104529755B
(zh)
*
|
2014-12-29 |
2016-01-06 |
精晶药业股份有限公司 |
一种从转化液中分离α-酮戊二酸的方法
|
|
CA2981754A1
(en)
|
2015-04-06 |
2016-10-13 |
Shenzhen Hightide Biopharmaceutical, Ltd. |
Conjugate compounds of ursodeoxycholic, berberine or l-carnitine, and compositions and methods thereof
|
|
JP2018517774A
(ja)
|
2015-06-10 |
2018-07-05 |
エリジウム・ヘルス・インコーポレイテッド |
ニコチンアミドリボシドおよびプテロスチルベン組成物ならびに皮膚障害の処置のための方法
|
|
WO2017008060A1
(en)
|
2015-07-08 |
2017-01-12 |
Unity Biotechnology, Inc. |
Compositions and methods for treating senescence-associated diseases and disorders
|
|
US20190247342A1
(en)
|
2016-09-30 |
2019-08-15 |
The Regents Of The University Of California |
Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth
|
|
PL231635B1
(pl)
*
|
2017-01-03 |
2019-03-29 |
Politechnika Poznanska |
Sposób produkcji kwasu alfa-ketoglutarowego (AKG) z jednoskładnikowych roztworów wodnych
|
|
MX2017004010A
(es)
|
2017-03-27 |
2018-02-09 |
Antonio Hernandez Miramontes Jorge |
Mezcla de oxalacetato, alfacetoglutarato, ácido tartánico y sales de lactato de calcio y sodio, para tratar pacientes con insuficiencia renal crónica.
|
|
EP3615029A4
(en)
|
2017-04-25 |
2021-04-21 |
Buck Institute for Research on Aging |
FORMULATIONS TO EXTEND LIFE AND HEALTH
|
|
US20200253907A1
(en)
|
2017-08-21 |
2020-08-13 |
The Regents Of The University Of California |
Compositions and Methods for Treating Neurodegenerative Diseases
|
|
JP7499259B2
(ja)
|
2018-09-25 |
2024-06-13 |
ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー |
αケトグルタル酸カルシウムを製造するためのプロセス
|
|
WO2020086733A1
(en)
|
2018-10-24 |
2020-04-30 |
Ponce De Leon Health Designated Activity Company |
Nicotinamide riboside compositions for healthspan extension
|
|
JP2022536653A
(ja)
|
2019-06-10 |
2022-08-18 |
バック インスティチュート フォー リサーチ オン エージング |
老化関連分泌表現型を修整する方法および組成物
|
|
DK3980001T3
(da)
*
|
2019-06-10 |
2025-12-01 |
Ponce De Leon Health Designated Activity Company |
Depotsammensætninger af alfa-ketoglutarat
|
|
CA3188646A1
(en)
|
2020-07-02 |
2022-01-06 |
Ponce De Leon Health Designated Activity Company |
Compositions and methods for treating crp-mediated diseases
|
|
CN112941116B
(zh)
*
|
2021-01-04 |
2022-12-02 |
上海朴颐化学科技有限公司 |
一种酶法制备α-酮戊二酸钙的方法
|
|
CN115974679A
(zh)
*
|
2022-12-20 |
2023-04-18 |
绍兴市精益生物化工有限公司 |
α-酮戊二酸钙盐制备方法
|