|
US4816463A
(en)
|
1986-04-01 |
1989-03-28 |
Warner-Lambert Company |
Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
|
|
US4812462A
(en)
|
1986-04-01 |
1989-03-14 |
Warner-Lambert Company |
4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
|
|
WO1992005784A1
(en)
|
1990-10-02 |
1992-04-16 |
Warner-Lambert Company |
4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine derivatives and analogues as angiotensin ii receptor antagonists
|
|
JP2005537290A
(ja)
|
2002-07-25 |
2005-12-08 |
ファルマシア・イタリア・エス・ピー・エー |
キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
|
|
CA2493625A1
(en)
|
2002-07-25 |
2004-02-19 |
Pharmacia Italia S.P.A. |
Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
US7145012B2
(en)
|
2003-04-23 |
2006-12-05 |
Pfizer Inc. |
Cannabinoid receptor ligands and uses thereof
|
|
GB0312609D0
(en)
|
2003-06-02 |
2003-07-09 |
Astrazeneca Ab |
Novel compounds
|
|
FR2857363B1
(fr)
|
2003-07-10 |
2007-09-07 |
Aventis Pharma Sa |
4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c] pyridines substituees compositions les contenant et utilisation
|
|
AR045037A1
(es)
*
|
2003-07-10 |
2005-10-12 |
Aventis Pharma Sa |
Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
|
|
ATE546452T1
(de)
|
2003-09-23 |
2012-03-15 |
Vertex Pharma |
Pyrazolopyrrolderivate als proteinkinaseinhibitoren
|
|
AU2005277283A1
(en)
|
2004-08-23 |
2006-03-02 |
Merck Sharp & Dohme Corp. |
Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
|
US20080146612A1
(en)
|
2005-01-27 |
2008-06-19 |
Astrazeneca Ab |
Novel Biaromatic Compounds, Inhibitors of the P2X7-Receptor
|
|
US7297700B2
(en)
|
2005-03-24 |
2007-11-20 |
Renovis, Inc. |
Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
|
|
WO2006110516A1
(en)
|
2005-04-11 |
2006-10-19 |
Abbott Laboratories |
Acylhydrazide p2x7 antagonists and uses thereof
|
|
JP2009531390A
(ja)
|
2006-03-31 |
2009-09-03 |
ノバルティス アクチエンゲゼルシャフト |
有機化合物
|
|
US7943617B2
(en)
|
2006-11-27 |
2011-05-17 |
Bristol-Myers Squibb Company |
Heterobicyclic compounds useful as kinase inhibitors
|
|
FR2915197B1
(fr)
|
2007-04-18 |
2009-06-12 |
Sanofi Aventis Sa |
Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
|
|
US8349858B2
(en)
|
2007-06-21 |
2013-01-08 |
Merck Sharp & Dohme |
Polycyclic guanine derivatives and use thereof
|
|
WO2009023623A1
(en)
|
2007-08-10 |
2009-02-19 |
H, Lundbeck A/S |
Heteroaryl amide analogues
|
|
FR2921342B1
(fr)
|
2007-09-20 |
2010-03-12 |
Airbus France |
Carenage aerodynamique arriere inferieur pour dispositif d'accrochage d'un moteur d'aeronef
|
|
EP2090576A1
(en)
|
2008-02-01 |
2009-08-19 |
Merz Pharma GmbH & Co.KGaA |
6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
|
|
CA2722035C
(en)
|
2008-04-22 |
2016-10-11 |
Janssen Pharmaceutica Nv |
Quinoline or isoquinoline substituted p2x7 antagonists
|
|
EP2370437B1
(en)
|
2008-11-25 |
2013-09-04 |
Nerviano Medical Sciences S.r.l. |
Bicyclic pyrazole and isoxazole derivatives as antitumor and antineurodegenerative agents
|
|
WO2010066629A2
(en)
|
2008-12-09 |
2010-06-17 |
F. Hoffmann-La Roche Ag |
Novel azaindoles
|
|
WO2010124122A1
(en)
|
2009-04-22 |
2010-10-28 |
Janssen Pharmaceutica Nv |
Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors
|
|
US8455476B2
(en)
|
2009-04-22 |
2013-06-04 |
Janssen Pharmaceutica, Nv |
Azetidinyl diamides as monoacylglycerol lipase inhibitors
|
|
ES2590987T3
(es)
|
2009-04-29 |
2016-11-24 |
Glaxo Group Limited |
Derivados de 5,6,7,8-tetrahidro[1,2,4]triazolo[4,3-a]pirazina como moduladores de P2X7
|
|
GB0907515D0
(en)
|
2009-04-30 |
2009-06-10 |
Glaxo Group Ltd |
Compounds
|
|
US8871760B2
(en)
|
2009-09-21 |
2014-10-28 |
Roche Palo Alto Llc |
[1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
|
|
WO2011050202A1
(en)
|
2009-10-23 |
2011-04-28 |
Janssen Pharmaceutica Nv |
Fused heterocyclic compounds as orexin receptor modulators
|
|
WO2011103715A1
(en)
|
2010-02-25 |
2011-09-01 |
Merck Sharp & Dohme Corp. |
Task channel antagonists
|
|
EP2552920B1
(en)
|
2010-04-02 |
2017-03-15 |
Ogeda Sa |
Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders
|
|
EP2558661A4
(en)
|
2010-04-16 |
2014-10-29 |
Fernandez Rodrigo Graf |
FOLDABLE STRUCTURES FOR CONSTRUCTION
|
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
|
US20130196986A1
(en)
|
2010-09-21 |
2013-08-01 |
Marc Labroli |
Triazolopyrazinones as p2x7 receptor antagonists
|
|
JP2013537920A
(ja)
*
|
2010-09-27 |
2013-10-07 |
ヤンセン ファーマシューティカ エヌ.ベー. |
モノアシルグリセロールリパーゼ阻害剤としてのオキソピペラジン−アゼチジンアミド及びオキソジアゼピン−アゼチジンアミド
|
|
WO2012054716A1
(en)
|
2010-10-22 |
2012-04-26 |
Janssen Pharmaceutica Nv. |
Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors
|
|
JP2013540160A
(ja)
*
|
2010-10-22 |
2013-10-31 |
ヤンセン ファーマシューティカ エヌ.ベー. |
モノアシルグリセロールリパーゼ阻害剤としてのアミノ−ピロリジン−アゼチジンジアミド
|
|
US9586962B2
(en)
|
2011-04-20 |
2017-03-07 |
Janssen Pharmaceutica Nv |
Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
|
|
WO2013050424A1
(en)
|
2011-10-03 |
2013-04-11 |
Euroscreen S.A. |
NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF
|
|
EP2766345B1
(en)
*
|
2011-10-14 |
2016-03-16 |
Bristol-Myers Squibb Company |
Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
|
|
US9273947B2
(en)
|
2012-02-07 |
2016-03-01 |
Lg Innotek Co., Ltd. |
Sensing magnet apparatus for motor
|
|
JP5205547B1
(ja)
|
2012-04-20 |
2013-06-05 |
株式会社ノイズ研究所 |
放射信号可視化装置
|
|
US9056874B2
(en)
|
2012-05-04 |
2015-06-16 |
Novartis Ag |
Complement pathway modulators and uses thereof
|
|
CN104718188B
(zh)
|
2012-05-22 |
2018-08-21 |
基因泰克公司 |
N-取代的苯甲酰胺类及其在治疗疼痛中的用途
|
|
US8859774B2
(en)
|
2012-05-25 |
2014-10-14 |
Corcept Therapeutics, Inc. |
Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
|
|
JO3459B1
(ar)
|
2012-09-09 |
2020-07-05 |
H Lundbeck As |
تركيبات صيدلانية لعلاج مرض الزهايمر
|
|
MX2015004721A
(es)
|
2012-10-15 |
2016-01-25 |
Epizyme Inc |
Compuestos de benceno sustituidos.
|
|
MY189505A
(en)
|
2012-10-16 |
2022-02-16 |
Janssen Pharmaceutica Nv |
Methylene linked quinolinyl modulators of roryt
|
|
CN104918945B
(zh)
|
2012-11-01 |
2018-01-05 |
因赛特公司 |
作为jak抑制剂的三环稠合噻吩衍生物
|
|
US9796729B2
(en)
|
2012-11-23 |
2017-10-24 |
Glaxosmithkline Llc |
Compounds as diacylglycerol acyltransferase inhibitors
|
|
WO2014100818A1
(en)
|
2012-12-21 |
2014-06-26 |
Quanticel Pharmaceuticals, Inc. |
Histone demethylase inhibitors
|
|
EP2935248B1
(en)
|
2012-12-21 |
2018-02-28 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
US9233974B2
(en)
|
2012-12-21 |
2016-01-12 |
Gilead Sciences, Inc. |
Antiviral compounds
|
|
AU2014214846A1
(en)
|
2013-02-08 |
2015-07-23 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
|
PT2964229T
(pt)
|
2013-03-06 |
2020-03-23 |
Janssen Pharmaceutica Nv |
Moduladores de piridina benzimidazol-2-ilo do recetor h4 de histamina
|
|
NO335177B1
(no)
|
2013-03-06 |
2014-10-13 |
Cambi Technology As |
Fremgangsmåte og anordning for termisk biologisk nedbryting og avvanning av biomasse
|
|
SG11201507255QA
(en)
|
2013-03-14 |
2015-10-29 |
Newlink Genetics Corp |
Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
|
|
PE20151727A1
(es)
|
2013-03-14 |
2015-12-17 |
Boehringer Ingelheim Int |
Acido 2-aza-biciclo[2.2.1]heptano-3-carboxilico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c
|
|
NZ710765A
(en)
|
2013-03-14 |
2020-05-29 |
Glaxosmithkline Ip No 2 Ltd |
2,3-disubstituted 1 -acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
|
|
CN105209449B
(zh)
|
2013-03-14 |
2019-02-01 |
库拉德夫制药私人有限公司 |
犬尿氨酸途径的抑制剂
|
|
WO2014152537A1
(en)
|
2013-03-14 |
2014-09-25 |
Janssen Pharmaceutica Nv |
P2x7 modulators
|
|
ES2654288T3
(es)
|
2013-03-14 |
2018-02-13 |
Janssen Pharmaceutica, N.V. |
Moduladores de P2X7
|
|
TWI627174B
(zh)
|
2013-03-14 |
2018-06-21 |
比利時商健生藥品公司 |
P2x7調控劑
|
|
JO3383B1
(ar)
|
2013-03-14 |
2019-03-13 |
Lilly Co Eli |
مثبطات cdc7
|
|
US9242969B2
(en)
|
2013-03-14 |
2016-01-26 |
Novartis Ag |
Biaryl amide compounds as kinase inhibitors
|
|
TWI644671B
(zh)
|
2013-03-14 |
2018-12-21 |
比利時商健生藥品公司 |
P2x7調節劑
|
|
JP6275242B2
(ja)
|
2013-03-29 |
2018-02-07 |
オゲダ エス.エー. |
選択的NK−3受容体拮抗薬としての新規なN−アシル−(3位置換)−(8−メチル)−5,6−ジヒドロ−[1,2,4]トリアゾロ[4,3−a]ピラジン、その医薬組成物、NK−3受容体媒介性障害で使用する方法
|
|
US20150057260A1
(en)
|
2013-08-22 |
2015-02-26 |
Genentech, Inc. |
Alkynyl alcohols and methods of use
|
|
US9611252B2
(en)
|
2013-12-30 |
2017-04-04 |
Lifesci Pharmaceuticals, Inc. |
Therapeutic inhibitory compounds
|
|
AU2015314851B2
(en)
|
2014-09-11 |
2020-01-02 |
Janssen Pharmaceutica Nv |
Substituted 2-azabicycles and their use as orexin receptor modulators
|
|
CA2960968A1
(en)
|
2014-09-12 |
2016-03-17 |
Janssen Pharmaceutica Nv |
P2x7 modulators
|
|
WO2016039983A1
(en)
|
2014-09-12 |
2016-03-17 |
Janssen Pharmaceutica Nv |
P2x7 modulating n-acyl-triazolopyrazines
|
|
RU2742305C2
(ru)
|
2014-12-30 |
2021-02-04 |
Новира Терапьютикс, Инк. |
Производные и способы лечения инфекций гепатита в
|
|
US10106556B2
(en)
|
2015-03-30 |
2018-10-23 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compound
|
|
TN2017000544A1
(en)
|
2015-07-31 |
2019-04-12 |
Pfizer |
1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors
|
|
WO2017087858A1
(en)
|
2015-11-20 |
2017-05-26 |
Abide Therapeutics, Inc. |
Pyrazole compounds and methods of making and using same
|
|
CN108017636A
(zh)
|
2016-11-04 |
2018-05-11 |
合帕吉恩治疗公司 |
作为fxr调节剂的含氮杂环化合物
|
|
US10934276B2
(en)
|
2016-12-16 |
2021-03-02 |
Vanderbilt University |
Positive allosteric modulators of the muscarinic acetylcholine receptor M4
|
|
CN110198944A
(zh)
|
2017-01-23 |
2019-09-03 |
辉瑞大药厂 |
作为单酰基甘油脂肪酶抑制剂的杂环螺环化合物
|
|
WO2020065614A1
(en)
|
2018-09-28 |
2020-04-02 |
Janssen Pharmaceutica Nv |
Monoacylglycerol lipase modulators
|
|
EP3856178B1
(en)
|
2018-09-28 |
2026-03-11 |
Janssen Pharmaceutica NV |
Monoacylglycerol lipase modulators
|
|
WO2020211798A1
(zh)
|
2019-04-16 |
2020-10-22 |
上海翰森生物医药科技有限公司 |
含二并环类衍生物抑制剂、其制备方法和应用
|
|
MX2022003819A
(es)
|
2019-09-30 |
2022-05-11 |
Janssen Pharmaceutica Nv |
Ligandos de pet de mgl radiomarcados.
|
|
BR112022019077A2
(pt)
|
2020-03-26 |
2022-12-27 |
Janssen Pharmaceutica Nv |
Moduladores da monoacilglicerol lipase
|