|
JPH0328966Y2
(https=)
|
1987-10-16 |
1991-06-20 |
|
|
|
CA2108451A1
(en)
|
1991-04-26 |
1992-10-27 |
Beverley J. Randle |
Novel antibodies, and methods for their use
|
|
US6955900B1
(en)
|
1993-02-02 |
2005-10-18 |
The Scripps Research Institute |
Methods for producing polypeptide binding sites, monoclonal antibodies and compositions thereof
|
|
US5981478A
(en)
|
1993-11-24 |
1999-11-09 |
La Jolla Cancer Research Foundation |
Integrin-binding peptides
|
|
JP4139508B2
(ja)
|
1998-02-19 |
2008-08-27 |
旭化成株式会社 |
ヒトデルター3
|
|
JP4332581B2
(ja)
|
1998-02-19 |
2009-09-16 |
旭化成株式会社 |
ヒトデルタ−3
|
|
US6344443B1
(en)
|
1998-07-08 |
2002-02-05 |
University Of South Florida |
Peptide antagonists of tumor necrosis factor alpha
|
|
PL209392B1
(pl)
|
1999-01-15 |
2011-08-31 |
Genentech Inc |
Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
|
|
AU2757500A
(en)
|
1999-02-10 |
2000-08-29 |
Human Genome Sciences, Inc. |
33 human secreted proteins
|
|
AU6913100A
(en)
|
1999-08-19 |
2001-03-13 |
Chiron Corporation |
Notch receptor ligands and uses thereof
|
|
US6436703B1
(en)
|
2000-03-31 |
2002-08-20 |
Hyseq, Inc. |
Nucleic acids and polypeptides
|
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
|
WO2002014358A2
(en)
|
2000-08-11 |
2002-02-21 |
Eli Lilly And Company |
Novel secreted proteins and their uses
|
|
EP1293514B1
(en)
|
2001-09-14 |
2006-11-29 |
Affimed Therapeutics AG |
Multimeric single chain tandem Fv-antibodies
|
|
AU2002330039A1
(en)
|
2001-09-17 |
2003-04-01 |
Eos Biotechnology, Inc. |
Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
|
|
AU2003295328A1
(en)
|
2002-10-02 |
2004-04-23 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US20040115204A1
(en)
|
2002-12-11 |
2004-06-17 |
Fanger Gary R. |
Antibodies to treat cancer
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
DK1709081T3
(da)
|
2004-01-16 |
2011-06-06 |
Regeneron Pharma |
Fusionspolypeptider, der kan aktivere receptorer
|
|
US20050175619A1
(en)
|
2004-02-05 |
2005-08-11 |
Robert Duffy |
Methods of producing antibody conjugates
|
|
EP2471813B1
(en)
|
2004-07-15 |
2014-12-31 |
Xencor, Inc. |
Optimized Fc variants
|
|
WO2006036834A2
(en)
|
2004-09-24 |
2006-04-06 |
Amgen Inc. |
MODIFIED Fc MOLECULES
|
|
AU2005299716B2
(en)
|
2004-10-22 |
2012-09-06 |
Amgen Inc. |
Methods for refolding of recombinant antibodies
|
|
CN101123983A
(zh)
|
2004-10-27 |
2008-02-13 |
米迪缪尼股份有限公司 |
特定修饰对相关抗原的亲和力来调节抗体的特异性
|
|
CA2585717A1
(en)
|
2004-10-27 |
2006-05-04 |
Medimmune Inc. |
Modulation of antibody specificity by tailoring the affinity to cognate antigens
|
|
EP1699826B1
(en)
|
2005-01-05 |
2009-03-11 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
|
|
WO2006083706A2
(en)
|
2005-01-31 |
2006-08-10 |
Vaxinnate Corporation |
Method to identify polypeptide toll-like receptor (tlr) ligands
|
|
AU2006232287B2
(en)
|
2005-03-31 |
2011-10-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for producing polypeptides by regulating polypeptide association
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US20070087005A1
(en)
|
2005-10-14 |
2007-04-19 |
Lazar Gregory A |
Anti-glypican-3 antibody
|
|
EP1960552A2
(en)
|
2005-12-16 |
2008-08-27 |
Genentech, Inc. |
Method for diagnosing, prognosing and treating glioma
|
|
US20100184021A1
(en)
|
2006-01-16 |
2010-07-22 |
Compugen Ltd. |
Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
|
|
AU2007238034A1
(en)
|
2006-04-14 |
2007-10-25 |
Trubion Pharmaceuticals Inc. |
Binding proteins comprising immunoglobulin hinge and Fc regions having altered Fc effector functions
|
|
WO2007134327A2
(en)
|
2006-05-15 |
2007-11-22 |
Sea Lane Biotechnologies, Llc. |
Neutralizing antibodies to influenza viruses
|
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
|
EP3040347A3
(en)
|
2006-10-20 |
2016-09-21 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
|
|
RU2769948C2
(ru)
|
2007-04-03 |
2022-04-11 |
Эмджен Рисерч (Мьюник) Гмбх |
CD3-Эпсилон-связывающий домен с межвидовой специфичностью
|
|
RS53008B2
(sr)
|
2007-04-03 |
2022-12-30 |
Amgen Res Munich Gmbh |
Interspecijski specifičan cd3-epsilon vezujući domen
|
|
EP2158221B1
(en)
|
2007-06-21 |
2018-08-29 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
|
US20090304719A1
(en)
|
2007-08-22 |
2009-12-10 |
Patrick Daugherty |
Activatable binding polypeptides and methods of identification and use thereof
|
|
CN101977932B
(zh)
|
2008-01-31 |
2014-09-03 |
美国政府健康及人类服务部 |
工程化抗体恒定结构域分子
|
|
JP2011516520A
(ja)
|
2008-04-07 |
2011-05-26 |
アブリンクス エン.ヴェー. |
Notch経路に指向性を有するアミノ酸配列及びその使用
|
|
TWI487712B
(zh)
|
2008-09-03 |
2015-06-11 |
建南德克公司 |
多重特異性抗體
|
|
CA2737241C
(en)
|
2008-09-26 |
2017-08-29 |
Ucb Pharma S.A. |
Multivalent antibody fusion proteins
|
|
DK2786762T3
(da)
|
2008-12-19 |
2019-05-06 |
Macrogenics Inc |
Kovalente diabodies og anvendelser deraf
|
|
DK2530091T3
(en)
|
2010-01-29 |
2018-05-28 |
Chugai Pharmaceutical Co Ltd |
ANTI-DLL3 ANTIBODY
|
|
WO2011108714A1
(ja)
|
2010-03-04 |
2011-09-09 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
EP2555622A4
(en)
|
2010-04-09 |
2013-09-18 |
Enanta Pharm Inc |
HEPATITIS C-VIRUS HEMMER
|
|
KR101860963B1
(ko)
|
2010-04-23 |
2018-05-24 |
제넨테크, 인크. |
이종다량체 단백질의 생산
|
|
ES2758994T3
(es)
|
2010-11-05 |
2020-05-07 |
Zymeworks Inc |
Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc
|
|
US9518132B2
(en)
|
2010-11-09 |
2016-12-13 |
Altimab Therapeutics, Inc. |
Protein complexes for antigen binding and methods of use
|
|
PT3434767T
(pt)
|
2010-11-30 |
2026-01-23 |
Chugai Pharmaceutical Co Ltd |
Agente terapêutico indutor de citotoxicidade
|
|
EP2663334A4
(en)
|
2011-01-10 |
2016-01-13 |
Univ Emory |
ANTIBODIES AGAINST INFLUENZA
|
|
AU2012245116A1
(en)
|
2011-04-20 |
2013-11-07 |
Genmab A/S |
Bispecific antibodies against HER2 and CD3
|
|
KR102060389B1
(ko)
|
2011-05-21 |
2019-12-31 |
마크로제닉스, 인크. |
사람 및 비-사람 cd3에 결합할 수 있는 cd3-결합 분자
|
|
TWI687439B
(zh)
|
2011-06-30 |
2020-03-11 |
中外製藥股份有限公司 |
異源二聚化多胜肽
|
|
WO2013010955A1
(en)
|
2011-07-15 |
2013-01-24 |
Morphosys Ag |
Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt)
|
|
WO2013026839A1
(en)
|
2011-08-23 |
2013-02-28 |
Roche Glycart Ag |
Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
|
|
NO2748201T3
(https=)
|
2011-08-23 |
2018-05-12 |
|
|
|
RU2654567C2
(ru)
|
2011-10-11 |
2018-05-21 |
Дженентек, Инк. |
Улучшенная сборка биспецифических антител
|
|
ES2654060T3
(es)
|
2011-10-20 |
2018-02-12 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Receptores de antígenos quiméricos anti-CD22
|
|
BR112014020826A8
(pt)
|
2012-02-24 |
2017-09-19 |
Stem Centrx Inc |
Anticorpo que se liga especificamente a um epítopo, ácido nucleico, vetor ou célula hospedeira, conjugado de fármaco anticorpo, composição farmacêutica compreendendo o referido anticorpo, uso do mesmo, kit e método de preparação do conjugado
|
|
WO2013180200A1
(ja)
|
2012-05-30 |
2013-12-05 |
中外製薬株式会社 |
標的組織特異的抗原結合分子
|
|
JP6628966B2
(ja)
|
2012-06-14 |
2020-01-15 |
中外製薬株式会社 |
改変されたFc領域を含む抗原結合分子
|
|
ES2876009T3
(es)
|
2012-12-27 |
2021-11-11 |
Chugai Pharmaceutical Co Ltd |
Polipéptido heterodimerizado
|
|
WO2014116846A2
(en)
|
2013-01-23 |
2014-07-31 |
Abbvie, Inc. |
Methods and compositions for modulating an immune response
|
|
GB201302447D0
(en)
|
2013-02-12 |
2013-03-27 |
Oxford Biotherapeutics Ltd |
Therapeutic and diagnostic target
|
|
KR102813659B1
(ko)
|
2013-11-11 |
2025-05-28 |
추가이 세이야쿠 가부시키가이샤 |
개변된 항체 가변영역을 포함하는 항원 결합 분자
|
|
CA2939941A1
(en)
|
2014-02-21 |
2015-08-27 |
Abbvie Stemcentrx Llc |
Anti-dll3 antibodies and drug conjugates for use in melanoma
|
|
JP2017509337A
(ja)
|
2014-03-12 |
2017-04-06 |
ノバルティス アーゲー |
イムノコンジュゲートを作製する抗体を修飾するための特定部位
|
|
US20170274072A1
(en)
|
2014-03-26 |
2017-09-28 |
Tohoku University |
Bispecific antibody targeting human epidermal growth factor receptor
|
|
AU2015244814B2
(en)
|
2014-04-07 |
2020-12-24 |
Chugai Seiyaku Kabushiki Kaisha |
Immunoactivating antigen-binding molecule
|
|
MX384418B
(es)
|
2014-07-31 |
2025-03-14 |
Amgen Res Munich Gmbh |
Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido.
|
|
EP3174901B1
(en)
|
2014-07-31 |
2019-06-26 |
Amgen Research (Munich) GmbH |
Optimized cross-species specific bispecific single chain antibody constructs
|
|
EP2982692A1
(en)
*
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
SG11201701128YA
(en)
|
2014-09-12 |
2017-03-30 |
Genentech Inc |
Cysteine engineered antibodies and conjugates
|
|
TWI831044B
(zh)
|
2014-11-11 |
2024-02-01 |
日商中外製藥股份有限公司 |
抗原結合分子、包含抗原結合分子的醫藥組合物以及製造及選擇抗原結合分子之方法
|
|
WO2016194992A1
(ja)
|
2015-06-05 |
2016-12-08 |
中外製薬株式会社 |
免疫活性化剤の併用
|
|
US9914777B2
(en)
|
2015-07-10 |
2018-03-13 |
Merus N.V. |
Human CD3 binding antibody
|
|
TWI793062B
(zh)
*
|
2015-07-31 |
2023-02-21 |
德商安美基研究(慕尼黑)公司 |
Dll3及cd3抗體構築體
|
|
WO2017191101A1
(en)
|
2016-05-02 |
2017-11-09 |
F. Hoffmann-La Roche Ag |
The contorsbody - a single chain target binder
|
|
WO2018027204A1
(en)
|
2016-08-05 |
2018-02-08 |
Genentech, Inc. |
Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
|
|
AU2017380981B2
(en)
|
2016-12-19 |
2025-01-30 |
F. Hoffmann-La Roche Ag |
Combination therapy with targeted 4-1BB (CD137) agonists
|
|
KR102692708B1
(ko)
|
2016-12-20 |
2024-08-07 |
에프. 호프만-라 로슈 아게 |
항-cd20/항-cd3 이중특이성 항체 및 4-1bb(cd137) 작용물질의 병용 요법
|
|
UY37726A
(es)
|
2017-05-05 |
2018-11-30 |
Amgen Inc |
Composición farmacéutica que comprende constructos de anticuerpos biespecíficos para almacenamiento y administración mejorados
|
|
TW201938194A
(zh)
|
2017-12-05 |
2019-10-01 |
日商中外製藥股份有限公司 |
包含結合cd3及cd137的改變的抗體可變區之抗原結合分子
|
|
JP7314146B2
(ja)
|
2017-12-28 |
2023-07-25 |
中外製薬株式会社 |
細胞傷害誘導治療剤
|
|
TWI848953B
(zh)
*
|
2018-06-09 |
2024-07-21 |
德商百靈佳殷格翰國際股份有限公司 |
針對癌症治療之多特異性結合蛋白
|
|
MX2021000827A
(es)
|
2018-08-03 |
2021-03-25 |
Chugai Pharmaceutical Co Ltd |
Molecula de union a antigeno que contiene dos dominios de union a antigeno que estan enlazados entre si.
|
|
BR112021005722A2
(pt)
|
2018-09-28 |
2021-07-06 |
Chugai Pharmaceutical Co Ltd |
moléculas de ligação ao antígeno capazes de ligar cd3 e cd137, porém não simultaneamente
|
|
US12509524B2
(en)
|
2018-09-28 |
2025-12-30 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule comprising altered antibody variable region
|
|
JP7611820B2
(ja)
*
|
2018-10-11 |
2025-01-10 |
インヒブルクス バイオサイエンシズ インコーポレイテッド |
Dll3シングルドメイン抗体およびその治療用組成物
|
|
CN115175930A
(zh)
|
2020-02-05 |
2022-10-11 |
中外制药株式会社 |
用于产生和/或富集重组抗原结合分子的方法
|
|
MX2022011387A
(es)
*
|
2020-03-31 |
2022-10-10 |
Chugai Pharmaceutical Co Ltd |
Metodo para producir moleculas de union a antigeno multiespecificas.
|
|
CR20220541A
(es)
|
2020-03-31 |
2022-11-28 |
Chugai Pharmaceutical Co Ltd |
Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usos
|