|
JPH0328966Y2
(https=)
|
1987-10-16 |
1991-06-20 |
|
|
|
IE921342A1
(en)
|
1991-04-26 |
1992-11-04 |
Surface Active Ltd |
Novel antibodies, and methods for their use
|
|
AU6235294A
(en)
|
1993-02-02 |
1994-08-29 |
Scripps Research Institute, The |
Methods for producing polypeptide binding sites
|
|
US5981478A
(en)
|
1993-11-24 |
1999-11-09 |
La Jolla Cancer Research Foundation |
Integrin-binding peptides
|
|
JP4139508B2
(ja)
|
1998-02-19 |
2008-08-27 |
旭化成株式会社 |
ヒトデルター３
|
|
JP4332581B2
(ja)
|
1998-02-19 |
2009-09-16 |
旭化成株式会社 |
ヒトデルタ−３
|
|
US6344443B1
(en)
|
1998-07-08 |
2002-02-05 |
University Of South Florida |
Peptide antagonists of tumor necrosis factor alpha
|
|
HU230769B1
(hu)
|
1999-01-15 |
2018-03-28 |
Genentech Inc. |
Módosított effektor-funkciójú polipeptid-változatok
|
|
JP2002540763A
(ja)
|
1999-02-10 |
2002-12-03 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
３３個のヒト分泌タンパク質
|
|
EP1206487A2
(en)
|
1999-08-19 |
2002-05-22 |
Chiron Corporation |
Notch receptor ligands and uses thereof
|
|
US6436703B1
(en)
|
2000-03-31 |
2002-08-20 |
Hyseq, Inc. |
Nucleic acids and polypeptides
|
|
CN101289511A
(zh)
|
2000-04-11 |
2008-10-22 |
杰南技术公司 |
多价抗体及其应用
|
|
EP1309614A2
(en)
|
2000-08-11 |
2003-05-14 |
Eli Lilly And Company |
Novel secreted proteins and their uses
|
|
DE60124912T2
(de)
|
2001-09-14 |
2007-06-14 |
Affimed Therapeutics Ag |
Multimerische, einzelkettige, Tandem-Fv-Antikörper
|
|
CA2459219A1
(en)
|
2001-09-17 |
2003-03-27 |
Protein Design Labs, Inc. |
Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
|
|
US20070224201A1
(en)
|
2002-10-02 |
2007-09-27 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US20040115204A1
(en)
|
2002-12-11 |
2004-06-17 |
Fanger Gary R. |
Antibodies to treat cancer
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
WO2005070966A2
(en)
|
2004-01-16 |
2005-08-04 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
US20050175619A1
(en)
|
2004-02-05 |
2005-08-11 |
Robert Duffy |
Methods of producing antibody conjugates
|
|
CN103172731A
(zh)
|
2004-07-15 |
2013-06-26 |
赞科股份有限公司 |
优化的Fc变体
|
|
EA011879B1
(ru)
|
2004-09-24 |
2009-06-30 |
Эмджин Инк. |
МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ
|
|
JP5553963B2
(ja)
|
2004-10-22 |
2014-07-23 |
アムジエン・インコーポレーテツド |
組換え抗体をリフォールディングする方法
|
|
US20060121042A1
(en)
|
2004-10-27 |
2006-06-08 |
Medimmune, Inc. |
Modulation of antibody specificity by tailoring the affinity to cognate antigens
|
|
CN101123983A
(zh)
|
2004-10-27 |
2008-02-13 |
米迪缪尼股份有限公司 |
特定修饰对相关抗原的亲和力来调节抗体的特异性
|
|
CN103555733A
(zh)
|
2005-01-05 |
2014-02-05 |
F-星生物技术研究与开发有限公司 |
分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域
|
|
CA2596248A1
(en)
|
2005-01-31 |
2006-08-10 |
Vaxinnate Corporation |
Method to identify polypeptide toll-like receptor (tlr) ligands
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
US20070087005A1
(en)
|
2005-10-14 |
2007-04-19 |
Lazar Gregory A |
Anti-glypican-3 antibody
|
|
US20070141066A1
(en)
|
2005-12-16 |
2007-06-21 |
Genentech, Inc. |
Method for Diagnosing, Prognosing and Treating Glioma
|
|
WO2007080597A2
(en)
|
2006-01-16 |
2007-07-19 |
Compugen Ltd. |
Polynucleotide and polypeptide sequences and methods for diagnosis
|
|
BRPI0710011A2
(pt)
|
2006-04-14 |
2011-08-02 |
Trubion Pharmaceuticals Inc |
proteìnas de ligação compreendendo articulação de imunoglobulina e regiões fc dotadas de funções efetoras fc alteradas
|
|
EP2024393A2
(en)
|
2006-05-15 |
2009-02-18 |
Sea Lane Biotechnologies,llc. |
Neutralizing antibodies to influenza viruses
|
|
AT503889B1
(de)
|
2006-07-05 |
2011-12-15 |
Star Biotechnologische Forschungs Und Entwicklungsges M B H F |
Multivalente immunglobuline
|
|
EP3040347A3
(en)
|
2006-10-20 |
2016-09-21 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
|
|
WO2008119565A2
(en)
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific binding domain
|
|
RS53008B2
(sr)
|
2007-04-03 |
2022-12-30 |
Amgen Res Munich Gmbh |
Interspecijski specifičan cd3-epsilon vezujući domen
|
|
EP3424951A1
(en)
|
2007-06-21 |
2019-01-09 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
|
CA2697032C
(en)
|
2007-08-22 |
2021-09-14 |
The Regents Of The University Of California |
Activatable binding polypeptides and methods of identification and use thereof
|
|
JP5889533B2
(ja)
|
2008-01-31 |
2016-03-22 |
ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ |
改変された抗体定常ドメイン分子
|
|
AU2009235467A1
(en)
|
2008-04-07 |
2009-10-15 |
Ablynx Nv |
Single variable domains against the Notch pathways
|
|
CN102143977B
(zh)
|
2008-09-03 |
2014-08-06 |
霍夫曼-拉罗奇有限公司 |
多特异性抗体
|
|
HRP20170374T1
(hr)
|
2008-09-26 |
2017-05-05 |
Ucb Biopharma Sprl |
Biološki proizvodi
|
|
EP2376109B1
(en)
|
2008-12-19 |
2019-01-23 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
|
EP3907242A1
(en)
|
2010-01-29 |
2021-11-10 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-dll3 antibody
|
|
JP5889181B2
(ja)
|
2010-03-04 |
2016-03-22 |
中外製薬株式会社 |
抗体定常領域改変体
|
|
EP2555622A4
(en)
|
2010-04-09 |
2013-09-18 |
Enanta Pharm Inc |
HEPATITIS C-VIRUS HEMMER
|
|
CN102946906B
(zh)
|
2010-04-23 |
2015-07-15 |
弗·哈夫曼-拉罗切有限公司 |
生产异源多聚体蛋白质
|
|
PL2635607T3
(pl)
|
2010-11-05 |
2020-05-18 |
Zymeworks Inc. |
Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
|
|
CA2817015A1
(en)
|
2010-11-09 |
2012-05-18 |
Altimab Therapeutics, Inc. |
Protein complexes for antigen binding and methods of use
|
|
RS67768B1
(sr)
|
2010-11-30 |
2026-03-31 |
Chugai Pharmaceutical Co Ltd |
Terapijski agens koji indukuje citotoksičnost
|
|
AU2012205663B2
(en)
|
2011-01-10 |
2017-02-02 |
Emory University |
Antibodies directed against influenza
|
|
CA2832389A1
(en)
|
2011-04-20 |
2012-10-26 |
Genmab A/S |
Bispecific antibodies against her2 and cd3
|
|
DK2714733T3
(da)
|
2011-05-21 |
2019-05-06 |
Macrogenics Inc |
Cd3-bindende molekyler, der er i stand til at binde til human og ikke-human cd3
|
|
CN109517059B
(zh)
|
2011-06-30 |
2023-03-28 |
中外制药株式会社 |
异源二聚化多肽
|
|
US9238689B2
(en)
|
2011-07-15 |
2016-01-19 |
Morpho Sys AG |
Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT)
|
|
MY169358A
(en)
|
2011-08-23 |
2019-03-26 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
BR112014004168A2
(pt)
|
2011-08-23 |
2017-12-12 |
Roche Glycart Ag |
anticorpo biespecífico, composição farmacêutica, uso do anticorpo biespecífico, célula hospedeira procariótica ou eucariótica, método de produção de anticorpo e invenção
|
|
CN107266577B
(zh)
|
2011-10-11 |
2022-09-13 |
弗·哈夫曼-拉罗切有限公司 |
双特异性抗体的改进的组装
|
|
WO2013059593A1
(en)
|
2011-10-20 |
2013-04-25 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-cd22 chimeric antigen receptors
|
|
PE20190658A1
(es)
|
2012-02-24 |
2019-05-08 |
Abbvie Stemcentrx Llc |
Moduladores y metodos de empleo novedosos
|
|
EP3795215A1
(en)
|
2012-05-30 |
2021-03-24 |
Chugai Seiyaku Kabushiki Kaisha |
Target tissue-specific antigen-binding molecule
|
|
EP4310191A3
(en)
|
2012-06-14 |
2024-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule containing modified fc region
|
|
US10766960B2
(en)
|
2012-12-27 |
2020-09-08 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
|
EP2948475A2
(en)
|
2013-01-23 |
2015-12-02 |
AbbVie Inc. |
Methods and compositions for modulating an immune response
|
|
GB201302447D0
(en)
|
2013-02-12 |
2013-03-27 |
Oxford Biotherapeutics Ltd |
Therapeutic and diagnostic target
|
|
TWI712421B
(zh)
|
2013-11-11 |
2020-12-11 |
日商中外製藥股份有限公司 |
含改變的抗體可變區之抗原結合分子
|
|
PE20161209A1
(es)
|
2014-02-21 |
2016-11-10 |
Abbvie Stemcentrx Llc |
Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma
|
|
CA2940451A1
(en)
|
2014-03-12 |
2015-09-17 |
Novartis Ag |
Specific sites for modifying antibodies to make immunoconjugates
|
|
WO2015146438A1
(ja)
|
2014-03-26 |
2015-10-01 |
国立大学法人東北大学 |
ヒト上皮増殖因子受容体を標的とした二重特異性抗体
|
|
CN118440206A
(zh)
|
2014-04-07 |
2024-08-06 |
中外制药株式会社 |
免疫活化抗原结合分子
|
|
AU2015295242B2
(en)
|
2014-07-31 |
2020-10-22 |
Amgen Research (Munich) Gmbh |
Bispecific single chain antibody construct with enhanced tissue distribution
|
|
ES2743809T3
(es)
|
2014-07-31 |
2020-02-20 |
Amgen Res Munich Gmbh |
Constructos de anticuerpo monocatenarios biespecificos específicos de especies cruzadas optimizados
|
|
EP2982692A1
(en)
*
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
|
MX2017003123A
(es)
|
2014-09-12 |
2017-05-12 |
Genentech Inc |
Anticuerpos y conjugados modificados geneticamente con cisteina.
|
|
TWI880146B
(zh)
|
2014-11-11 |
2025-04-11 |
日商中外製藥股份有限公司 |
包含經改變之抗體可變區之抗原結合分子的資料庫
|
|
US20180171017A1
(en)
|
2015-06-05 |
2018-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Combined use of immune activators
|
|
SI3115376T1
(sl)
|
2015-07-10 |
2018-12-31 |
Merus N.V. |
Humana protitelesa, ki vežejo CD3
|
|
TWI793062B
(zh)
|
2015-07-31 |
2023-02-21 |
德商安美基研究（慕尼黑）公司 |
Ｄｌｌ３及ｃｄ３抗體構築體
|
|
AU2017259869A1
(en)
|
2016-05-02 |
2018-09-27 |
F. Hoffmann-La Roche Ag |
The contorsbody - a single chain target binder
|
|
US11046776B2
(en)
|
2016-08-05 |
2021-06-29 |
Genentech, Inc. |
Multivalent and multiepitopic antibodies having agonistic activity and methods of use
|
|
WO2018114754A1
(en)
|
2016-12-19 |
2018-06-28 |
F. Hoffmann-La Roche Ag |
Combination therapy with targeted 4-1bb (cd137) agonists
|
|
AU2017384126B2
(en)
|
2016-12-20 |
2025-01-23 |
F. Hoffmann-La Roche Ag |
Combination therapy of anti-CD20/anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists
|
|
MX2019013142A
(es)
|
2017-05-05 |
2019-12-16 |
Amgen Inc |
Composicion farmaceutica que comprende construcciones de anticuerpos biespecificas para mejorar el almacenamiento y la administracion.
|
|
TW201938194A
(zh)
*
|
2017-12-05 |
2019-10-01 |
日商中外製藥股份有限公司 |
包含結合cd3及cd137的改變的抗體可變區之抗原結合分子
|
|
US11667713B2
(en)
|
2017-12-28 |
2023-06-06 |
Chugai Seiyaku Kabushiki Kaisha |
Cytotoxicity-inducing therapeutic agent
|
|
TWI848953B
(zh)
*
|
2018-06-09 |
2024-07-21 |
德商百靈佳殷格翰國際股份有限公司 |
針對癌症治療之多特異性結合蛋白
|
|
MX2021000827A
(es)
|
2018-08-03 |
2021-03-25 |
Chugai Pharmaceutical Co Ltd |
Molecula de union a antigeno que contiene dos dominios de union a antigeno que estan enlazados entre si.
|
|
KR20210068079A
(ko)
|
2018-09-28 |
2021-06-08 |
추가이 세이야쿠 가부시키가이샤 |
Cd3 및 cd137에 결합할 수 있지만 동시에는 결합하지 않는 항원 결합 분자
|
|
BR112021005472A2
(pt)
|
2018-09-28 |
2021-06-15 |
Chugai Seiyaku Kabushiki Kaisha |
molécula de ligação ao antígeno compreendendo uma região variável do anticorpo alterada
|
|
EP3864045A2
(en)
*
|
2018-10-11 |
2021-08-18 |
Inhibrx, Inc. |
Dll3 single domain antibodies and therapeutic compositions thereof
|
|
CN115175930A
(zh)
|
2020-02-05 |
2022-10-11 |
中外制药株式会社 |
用于产生和/或富集重组抗原结合分子的方法
|
|
US20230121511A1
(en)
|
2020-03-31 |
2023-04-20 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing multispecific antigen-binding molecules
|
|
TWI909146B
(zh)
|
2020-03-31 |
2025-12-21 |
日商中外製藥股份有限公司 |
Dll3靶向之多特異性抗原結合分子及其用途
|