BR112021005722A2 - moléculas de ligação ao antígeno capazes de ligar cd3 e cd137, porém não simultaneamente - Google Patents

moléculas de ligação ao antígeno capazes de ligar cd3 e cd137, porém não simultaneamente

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Publication number
BR112021005722A2
BR112021005722A2 BR112021005722A BR112021005722A BR112021005722A2 BR 112021005722 A2 BR112021005722 A2 BR 112021005722A2 BR 112021005722 A BR112021005722 A BR 112021005722A BR 112021005722 A BR112021005722 A BR 112021005722A BR 112021005722 A2 BR112021005722 A2 BR 112021005722A2
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Brazil
Prior art keywords
binding
antigen
binding molecules
molecules capable
variable region
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BR112021005722A
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English (en)
Inventor
Feng Shu
Wen Samantha Ho Shu
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Chugai Pharmaceutical Co Ltd
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Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR112021005722A2 publication Critical patent/BR112021005722A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/526—CH3 domain
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

moléculas de ligação ao antígeno capazes de ligar cd3 e cd137, porém não simultaneamente. a presente invenção refere-se às moléculas de ligação ao antígeno que se ligam ao cd3 e cd137 (4-1bb); composições compreendendo a molécula de ligação ao antígeno; e métodos de uso das mesmas. a presente invenção fornece moléculas de ligação ao antígeno compreendendo: uma região variável de anticorpo que é capaz de ligar-se ao cd3 e cd137 (4-1bb), porém não ligar-se ao cd3 e cd137 ao mesmo tempo; e uma região variável que se ligam a um terceiro antígeno diferente de cd3 e cd137. tais moléculas de ligação ao antígeno exibem atividade de citotoxicidade dependente de célula t induzida por estas moléculas de ligação ao antígeno através da ligação a três antígenos diferentes.
BR112021005722A 2018-09-28 2019-09-27 moléculas de ligação ao antígeno capazes de ligar cd3 e cd137, porém não simultaneamente BR112021005722A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018185120 2018-09-28
JP2019104308 2019-06-04
PCT/JP2019/038138 WO2020067419A1 (en) 2018-09-28 2019-09-27 Antigen-binding molecules capable of binding cd3 and cd137 but not simultaneously

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BR112021005722A2 true BR112021005722A2 (pt) 2021-07-06

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BR112021005722A BR112021005722A2 (pt) 2018-09-28 2019-09-27 moléculas de ligação ao antígeno capazes de ligar cd3 e cd137, porém não simultaneamente

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US (1) US20210388087A1 (pt)
EP (1) EP3856785A4 (pt)
JP (1) JP2022502010A (pt)
KR (1) KR20210068079A (pt)
CN (1) CN113166247A (pt)
AU (1) AU2019347412A1 (pt)
BR (1) BR112021005722A2 (pt)
CA (1) CA3114154A1 (pt)
CL (1) CL2021000739A1 (pt)
CO (1) CO2021005528A2 (pt)
CR (1) CR20210199A (pt)
IL (1) IL281787A (pt)
MA (1) MA53742A (pt)
MX (1) MX2021003608A (pt)
PE (1) PE20211072A1 (pt)
PH (1) PH12021550662A1 (pt)
SG (1) SG11202101912UA (pt)
TW (1) TW202028238A (pt)
WO (1) WO2020067419A1 (pt)

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EP2862875B1 (en) 2012-06-14 2023-09-06 Chugai Seiyaku Kabushiki Kaisha ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED Fc REGION
EA201600354A1 (ru) 2013-11-11 2016-12-30 Чугаи Сеияку Кабушики Каиша Антигенсвязывающая молекула, содержащая вариабельную область антитела
JP7125248B2 (ja) 2014-11-11 2022-08-24 中外製薬株式会社 改変された抗体可変領域を含む抗原結合分子のライブラリ
TW201938194A (zh) 2017-12-05 2019-10-01 日商中外製藥股份有限公司 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子
TWI817974B (zh) 2017-12-28 2023-10-11 日商中外製藥股份有限公司 細胞毒性誘導治療劑
US20230147840A1 (en) * 2020-03-31 2023-05-11 Chugai Seiyaku Kabushiki Kaisha Immune activating multispecific antigen-binding molecules and uses thereof
CN115397866A (zh) 2020-03-31 2022-11-25 中外制药株式会社 靶向dll3的多特异性抗原结合分子及其用途
KR20220161375A (ko) * 2020-03-31 2022-12-06 추가이 세이야쿠 가부시키가이샤 다중 특이성 항원 결합 분자를 제조하기 위한 방법
WO2023036043A1 (zh) * 2021-09-09 2023-03-16 广东东阳光药业有限公司 抗癌结合分子及其应用
WO2023053272A1 (en) * 2021-09-29 2023-04-06 Chugai Seiyaku Kabushiki Kaisha Uses of dll3-targeting multispecific antigen-binding molecules
WO2023053282A1 (ja) * 2021-09-29 2023-04-06 中外製薬株式会社 がんの治療に用いるための細胞傷害誘導治療剤
JP7470760B2 (ja) * 2021-09-29 2024-04-18 中外製薬株式会社 がんの治療に用いるための細胞傷害誘導治療剤
WO2024114676A1 (zh) * 2022-11-29 2024-06-06 江苏恒瑞医药股份有限公司 Cldn18.2/4-1bb结合蛋白及其医药用途

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KR101077001B1 (ko) 1999-01-15 2011-10-26 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
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EA201600354A1 (ru) * 2013-11-11 2016-12-30 Чугаи Сеияку Кабушики Каиша Антигенсвязывающая молекула, содержащая вариабельную область антитела
EP3130606B1 (en) * 2014-04-07 2021-10-13 Chugai Seiyaku Kabushiki Kaisha Immunoactivating bispecific antibodies
JP7125248B2 (ja) * 2014-11-11 2022-08-24 中外製薬株式会社 改変された抗体可変領域を含む抗原結合分子のライブラリ
MX2019006954A (es) * 2016-12-20 2019-08-01 Hoffmann La Roche Terapia de combinacion de anticuerpos biespecificos anti-cd20/anti-cd3 y agonistas de 4-1bb (cd137).
TW201938194A (zh) * 2017-12-05 2019-10-01 日商中外製藥股份有限公司 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子

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SG11202101912UA (en) 2021-04-29
EP3856785A1 (en) 2021-08-04
CR20210199A (es) 2021-06-11
CA3114154A1 (en) 2020-04-02
AU2019347412A1 (en) 2021-05-27
MA53742A (fr) 2022-01-05
US20210388087A1 (en) 2021-12-16
MX2021003608A (es) 2021-05-28
WO2020067419A1 (en) 2020-04-02
CN113166247A (zh) 2021-07-23
PE20211072A1 (es) 2021-06-09
CO2021005528A2 (es) 2021-07-30
PH12021550662A1 (en) 2021-12-13
JP2022502010A (ja) 2022-01-11
CL2021000739A1 (es) 2021-09-24
TW202028238A (zh) 2020-08-01
KR20210068079A (ko) 2021-06-08
EP3856785A4 (en) 2022-07-06
IL281787A (en) 2021-05-31

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